{"id":25812,"date":"2019-06-28T08:00:28","date_gmt":"2019-06-28T00:00:28","guid":{"rendered":"\/\/www.gsbet888.com\/?p=25812"},"modified":"2019-07-01T17:07:04","modified_gmt":"2019-07-01T09:07:04","slug":"%e6%89%8b%e6%80%a7%e7%a3%b7%e5%82%ac%e5%8c%963-%e5%8f%a0%e6%b0%ae%e4%b8%99%e5%9f%ba%e8%8c%9a%e4%ba%8c%e9%85%ae%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0staudinger-aza-wittig%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2019\/06\/%e6%89%8b%e6%80%a7%e7%a3%b7%e5%82%ac%e5%8c%963-%e5%8f%a0%e6%b0%ae%e4%b8%99%e5%9f%ba%e8%8c%9a%e4%ba%8c%e9%85%ae%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0staudinger-aza-wittig%e5%8f%8d%e5%ba%94.html","title":{"rendered":"\u624b\u6027\u78f7\u50ac\u53163-\u53e0\u6c2e\u4e19\u57fa\u831a\u4e8c\u916e\u7684\u4e0d\u5bf9\u79f0Staudinger-aza-Wittig\u53cd\u5e94"},"content":{"rendered":"<p>\u624b\u6027\u6742\u73af\u80fa\u7279\u522b\u662f\u516d\u5143\u6742\u73af\u80fa\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5929\u7136\u4ea7\u7269\u3001\u5177\u6709\u6d3b\u6027\u7684\u5316\u5408\u7269\u4ee5\u53ca\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u5c0f\u5206\u5b50\u836f\u7269\u4e2d\uff0c\u56e0\u6b64\u8be5\u7c7b\u5316\u5408\u7269\u7684\u5408\u6210\u53d7\u5230\u5316\u5b66\u5bb6\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u4f46\u542b\u5b63\u78b3\u624b\u6027\u4e2d\u5fc3\u5f97\u6742\u73af\u80fa\u7684\u5236\u5907\u6761\u4ef6\u7279\u522b\u82db\u523b\uff0c\u56e0\u6b64\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821(UCLA)\u7684<a href=\"https:\/\/www.chemistry.ucla.edu\/directory\/kwon-ohyun\">Ohyun Kwon<\/a>\u8bfe\u9898\u7ec4\u5c06\u76ee\u5149\u6295\u5411\u4e86\u5ba4\u6e29\u6761\u4ef6\u5c31\u80fd\u53d1\u751f\u7684\u916e\u7684Staudinger\u2212aza-Wittig\u53cd\u5e94\u30022006\u5e74\uff0cMarsden\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u7b2c\u4e00\u4f8b\u624b\u6027\u5641\u5511\u78f7\u70f7\u6216\u4e8c\u6c2e\u78f7\u70f7\u50ac\u53162-(3-\u53e0\u6c2e\u57fa\u4e19\u57fa)-1,3-\u4e8c\u916e\u7684\u4e0d\u5bf9\u79f0Staudinger-aza-Wittig\u53cd\u5e94\uff0c\u5408\u6210\u516d\u5143\u6742\u73af\u80fa\u5316\u5408\u7269[1]\u3002\u4f46\u8be5\u53cd\u5e94\u9700\u8981\u5e94\u7528\u7b49\u5316\u5b66\u5f53\u91cf\u7684\u624b\u6027\u50ac\u5316\u5242\u3002\u6700\u8fd1\uff0cWerner\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u7b2c\u4e00\u4f8b\u5fae\u6ce2\u6216\u9ad8\u6e29\u9a71\u52a8\u916e\u7684\u4e0d\u5bf9\u79f0Wittig\u53cd\u5e94\uff0c\u4f46\u53ea\u80fd\u4ee5\u4e2d\u7b49\u7684\u6536\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269[2]\u3002\u5728\u4e0a\u8ff0\u80cc\u666f\u7814\u7a76\u7684\u57fa\u7840\u4e0a\uff0c<a href=\"https:\/\/www.chemistry.ucla.edu\/directory\/kwon-ohyun\">Ohyun Kwon<\/a>\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86L-\u7f9f\u57fa\u812f\u6c28\u9178\u884d\u751f\u7684\u624b\u6027\u78f7\u50ac\u5316\u5242\u50ac\u53163-\u53e0\u6c2e\u4e19\u57fa\u831a\u4e8c\u916e\u7684\u4e0d\u5bf9\u79f0Staudinger-aza-Wittig\u53cd\u5e94\uff0c\u6784\u5efa\u516d\u5143\u6742\u73af\u80fa\u5316\u5408\u7269(Scheme 1)\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e<\/p>\n<blockquote><p>Catalytic Asymmetric Staudinger\u2212aza-Wittig Reaction for the Synthesis of Heterocyclic Amines<\/p>\n<p>Cai, L.; Zhang, K.; Chen, S.; Lepage, R. J.; Houk, K. N.; Krenske, E. H.; Kwon, O. * <em>J. Am. Chem. Soc.<\/em> <strong>2019<\/strong>,<em> 141<\/em>, 9537-9542<\/p>\n<p><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.9b04803\">DOI: 10.1021\/jacs.9b04803<\/a><\/p><\/blockquote>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/2-24.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25814 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/2-24-680x341.png\" alt=\"\" width=\"680\" height=\"341\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/2-24-680x341.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/2-24-300x151.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/2-24-768x386.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/2-24.png 912w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a> <a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/3-21.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25815 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/3-21-680x422.png\" alt=\"\" width=\"680\" height=\"422\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/3-21-680x422.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/3-21-300x186.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/3-21-768x477.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/3-21-233x144.png 233w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/3-21.png 886w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a> <a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/4-21.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25816 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/4-21-680x345.png\" alt=\"\" width=\"680\" height=\"345\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/4-21-680x345.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/4-21-300x152.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/4-21-768x390.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/4-21.png 901w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<h4><strong>\u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd\uff1a<\/strong><\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/5-18.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25817 size-medium\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/5-18-227x300.png\" alt=\"\" width=\"227\" height=\"300\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/5-18-227x300.png 227w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/5-18.png 302w\" sizes=\"(max-width: 227px) 100vw, 227px\" \/><\/a><\/p>\n<p>\u7814\u7a76\u8005\uff1a<a href=\"https:\/\/www.chemistry.ucla.edu\/directory\/kwon-ohyun\">Ohyun Kwon<\/a>\u6559\u6388<\/p>\n<h4><strong>\u7814\u7a76\u8005\u7ecf\u5386\uff1a<\/strong><\/h4>\n<ul>\n<li>1991\uff0cB.S.\uff0cSeoul National University<\/li>\n<li>1993\uff0cM.S.\uff0c Seoul National University<\/li>\n<li>1998\uff0cPh.D.\uff0cColumbia University<\/li>\n<li>1998\uff0cHoward Hughes Postdoctoral Fellow\uff0cHarvard University<\/li>\n<li>2001\uff0cassistant professor\uff0cUCLA<\/li>\n<li>2005\uff0cmember of the Molecular Biology Institute (MBI) and UCLA Jonsson Comprehensive Cancer Center (JCCC)<\/li>\n<\/ul>\n<h4><strong>\u8363\u8a89\u5956\u9879<\/strong><\/h4>\n<ul>\n<li>Amgen Young Investigator&#8217;s Award<\/li>\n<li>Synthesis and Synlett Thieme Journal Award<\/li>\n<li>UCLA Faculty Career Development Award<\/li>\n<li>Glenn T. Seaborg Award<\/li>\n<li>Columbia University KAST Fellowship<\/li>\n<\/ul>\n<h4>\u7814\u7a76\u9886\u57df<\/h4>\n<p>organic\/Chemical Biology\/Synthesis<\/p>\n<h4><strong>\u8bba\u6587\u6982\u8981<\/strong><\/h4>\n<p>\u4ee53-\u53e0\u6c2e\u4e19\u57fa\u831a\u4e8c\u916e\u4e3a\u6a21\u677f\u5e95\u7269\uff0c\u901a\u8fc7\u53cd\u590d\u7b5b\u9009\u53cd\u5e94\u6761\u4ef6\uff0c\u4f5c\u8005\u7b5b\u9009\u51fa\u6700\u4f18\u53cd\u5e94\u6761\u4ef6\uff1a20 mol%\u7684\u624b\u6027\u78f7\u50ac\u5316\u5242<strong>A<\/strong>\u6216<strong>B<\/strong>\uff0c20 mol% 2-\u785d\u57fa\u82ef\u7532\u9178\u30012 equiv PhSiH<sub>3<\/sub>\u30014\u00c5 MS\u4e3a\u6dfb\u52a0\u7269\uff0c\u7532\u82ef\u4e3a\u6eb6\u5242\uff0c\u5728\u5ba4\u6e29\u6761\u4ef6\u4e0b\u53cd\u5e9448 h\uff0c\u80fd\u4ee599%\u7684\u6536\u7387\u548c90%\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269\uff08Figure 1a\uff09\u3002<\/p>\n<p>\u4e3a\u4e86\u8fdb\u4e00\u6b65\u63a2\u7d22\u8be5\u53cd\u5e94\u5bf9\u6620\u9009\u62e9\u6027\u7684\u51b3\u5b9a\u56e0\u7d20\uff0c\u4f5c\u8005\u8003\u5bdf\u4e86\u82ef\u7532\u9178\u5bf9\u624b\u6027\u81a6\u50ac\u5316\u5242<strong>A<\/strong>\u548c\u53e0\u6c2e\u5316\u7269<strong>1f<\/strong>\u53d1\u751faza-Wittig\u53cd\u5e94\u751f\u6210\u7684\u81a6\u4e9a\u80fa<strong>3<\/strong>\u7684\u81ea\u7531\u80fd\u5f71\u54cd\u66f2\u7ebf\u3002\u8ba1\u7b97\u7ed3\u679c\u8868\u660e\u8be5\u53cd\u5e94\u7ecf\u5386\u4e2d\u95f4\u4f53<strong>4\u2032<\/strong>\u53d1\u751f[2+2]\/\u9006-[2+2]\u73af\u52a0\u6210\u53cd\u5e94\uff0c\u5176\u5bf9\u6620\u9009\u62e9\u6027\u7531\u624b\u6027\u50ac\u5316\u5242\u548c\u9178\u6dfb\u52a0\u7269\u5171\u540c\u51b3\u5b9a\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u63d0\u51fa\u53ef\u80fd\u7684\u53cd\u5e94\u673a\u7406\uff1a\u81a6\u4e9a\u80fa<strong>3<\/strong>\u5728\u9178\u6027\u4f5c\u7528\u4e0b\u53d1\u751f\u8d28\u5b50\u5316\u8fc7\u7a0b\u751f\u6210\u79bb\u5b50\u5bf93\u2033\u30023\u2033\u53ef\u53d1\u751f\u5f02\u6784\u5316\u8f6c\u5316\u4e3a\u76f8\u5bf9\u4e0d\u7a33\u5b9a\u7684\u6c22\u952e\u590d\u5408\u7269<strong>3\u2032<\/strong>\u3002<strong>3\u2032<\/strong>\u65e2\u53ef\u6d3b\u5316\u5206\u5b50\u5185[2+2]\u73af\u52a0\u6210\u7684\u7fb0\u57fa\uff0c\u53c8\u53ef\u52a0\u5feb\u9006-[2+2]\u73af\u52a0\u6210\u7684\u53cd\u5e94\u901f\u5ea6\u3002\u4f46[2+2]\u73af\u52a0\u6210\uff08TS3a&#8217;\uff09\u7684\u901f\u5ea6\u660e\u663e\u9ad8\u4e8e\u9006-[2+2]\u73af\u52a0\u6210\u7684\u53cd\u5e94\u901f\u5ea6\uff08TS4b&#8217;\uff09\uff0c\u800c\u5bf9\u6620\u9009\u62e9\u6027\u53d6\u51b3\u4e8e\u7a33\u5b9a\u7684\u4e2d\u95f4\u4f53TS4a&#8217;\uff08Figure 1b, c\uff09\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/6-15.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25818 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/6-15.png\" alt=\"\" width=\"1052\" height=\"602\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/6-15.png 1052w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/6-15-300x172.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/6-15-768x439.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/6-15-680x389.png 680w\" sizes=\"(max-width: 1052px) 100vw, 1052px\" \/><\/a><\/p>\n<p>\u7d27\u63a5\u7740\uff0c\u5728\u6700\u4f18\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u8be5\u4e0d\u5bf9\u79f0Staudinger-aza-Wittig\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u4e86\u8003\u5bdf\uff08Scheme 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href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/8-9.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25819 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/7-13.png\" alt=\"\" width=\"932\" height=\"587\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/7-13.png 932w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/7-13-300x189.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/7-13-768x484.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/7-13-680x428.png 680w\" sizes=\"(max-width: 932px) 100vw, 932px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25820\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/8-9.png\" alt=\"\" width=\"900\" height=\"288\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/8-9.png 1095w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/8-9-300x96.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/8-9-768x246.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/8-9-680x218.png 680w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><\/a><\/p>\n<p>\u831a[1,2-b]\u54cc\u5576\u9aa8\u67b6\u7684\u5316\u5408\u7269\u53ef\u4f5c\u4e3a<em>N<\/em>-\u7532\u57fa- D-\u5929\u51ac\u6c28\u9178\u53d7\u4f53\u62ee\u6297\u5242\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u7b80\u5355\u7684\u884d\u751f\u53cd\u5e94\uff0c\u4f5c\u8005\u53ef\u5c06<strong>2a<\/strong>\u8f6c\u5316\u4e3a\u91cd\u8981\u7684\u4e09\u7ea7\u80fa<strong>8<\/strong>\u3001\u4e9a\u80fa<strong>10<\/strong>\u4ee5\u53ca\u53cd\u5f0f\u73af\u8fde\u63a5\u7684\u5316\u5408\u7269<strong>11<\/strong>\uff08Scheme 3\uff09\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/9-5.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25821 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/9-5-680x512.png\" alt=\"\" width=\"680\" height=\"512\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/9-5-680x512.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/9-5-300x226.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/9-5-768x578.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/9-5.png 818w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a> <a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/10-4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25822 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/10-4-680x379.png\" alt=\"\" width=\"680\" height=\"379\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/10-4-680x379.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/10-4-300x167.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/10-4-768x428.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/10-4.png 795w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<h4><strong>\u8bba\u6587\u603b\u7ed3\u8bc4\u4ef7\uff1a<\/strong><\/h4>\n<p>\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821(UCLA)\u7684<a href=\"https:\/\/www.chemistry.ucla.edu\/directory\/kwon-ohyun\">Ohyun Kwon<\/a>\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86L-\u7f9f\u57fa\u812f\u6c28\u9178\u884d\u751f\u7684\u624b\u6027\u78f7\u50ac\u5316\u5242\u50ac\u53163-\u53e0\u6c2e\u4e19\u57fa\u831a\u4e8c\u916e\u7684\u4e0d\u5bf9\u79f0Staudinger-aza-Wittig\u53cd\u5e94\uff0c\u6784\u5efa\u516d\u5143\u6742\u73af\u80fa\u5316\u5408\u7269\u3002\u8be5\u65b9\u6cd5\u4e3a\u4e0d\u5bf9\u79f0\u516d\u5143\u6742\u73af\u80fa\u5316\u5408\u7269\u7684\u5408\u6210\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u7b80\u4fbf\u7684\u65b9\u6cd5\u3002<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ol>\n<li>Lertpibulpanya, D.; Marsden, S. P.<em> Angew.\u00a0Chem., Int. Ed. <\/em><strong>2006<\/strong>,<em> 45<\/em>, 5000. DOI: <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.200601366\">10.1002\/anie.200601366<\/a><\/li>\n<li>Werner, T.; Hoffmann, M.; Deshmukh, S.<em> J. Org. Chem.<\/em> <strong>2014<\/strong>, <em>2014<\/em>, 6630. DOI: <a href=\"https:\/\/doi.org\/10.1002\/anie.200601366\">10.1002\/ejoc.201402941<\/a><\/li>\n<\/ol>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"\u624b\u6027\u6742\u73af\u80fa\u7279\u522b\u662f\u516d\u5143\u6742\u73af\u80fa\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5929\u7136\u4ea7\u7269\u3001\u5177\u6709\u6d3b\u6027\u7684\u5316\u5408\u7269\u4ee5\u53ca\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u5c0f\u5206\u5b50\u836f\u7269\u4e2d\uff0c\u56e0\u6b64\u8be5\u7c7b\u5316\u5408\u7269\u7684\u5408\u6210\u53d7\u5230\u5316\u5b66\u5bb6\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u4f46\u542b\u5b63\u78b3\u624b\u6027\u4e2d\u5fc3\u5f97\u6742\u73af\u80fa\u7684\u5236\u5907\u6761\u4ef6\u7279\u522b\u82db\u523b\uff0c\u56e0\u6b64\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821(UCLA)\u7684Ohyun Kwon\u8bfe\u9898\u7ec4\u5c06\u76ee\u5149\u6295\u5411\u4e86\u5ba4\u6e29\u6761\u4ef6\u5c31\u80fd\u53d1\u751f\u7684\u916e\u7684Staudinger\u2212aza-Wittig\u53cd\u5e94\u30022006\u5e74\uff0cMarsden\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u7b2c\u4e00\u4f8b\u624b\u6027\u5641\u5511\u78f7\u70f7\u6216\u4e8c\u6c2e\u78f7\u70f7\u50ac\u53162-(3-\u53e0\u6c2e\u57fa\u4e19\u57fa)-1,3-\u4e8c\u916e\u7684\u4e0d\u5bf9\u79f0Staudinger-aza-Wittig\u53cd\u5e94\uff0c\u5408\u6210\u516d\u5143\u6742\u73af\u80fa\u5316\u5408\u7269[1]\u3002\u4f46\u8be5\u53cd\u5e94\u9700\u8981\u5e94\u7528\u7b49\u5316\u5b66\u5f53\u91cf\u7684\u624b\u6027\u50ac\u5316\u5242\u3002\u6700\u8fd1\uff0cWerner\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u7b2c\u4e00\u4f8b\u5fae\u6ce2\u6216\u9ad8\u6e29\u9a71\u52a8\u916e\u7684\u4e0d\u5bf9\u79f0Wittig\u53cd\u5e94\uff0c\u4f46\u53ea\u80fd\u4ee5\u4e2d\u7b49\u7684\u6536\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269[2]\u3002\u5728\u4e0a\u8ff0\u80cc\u666f\u7814\u7a76\u7684\u57fa\u7840\u4e0a\uff0cOhyun Kwon\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86L-\u7f9f\u57fa\u812f\u6c28\u9178\u884d\u751f\u7684\u624b\u6027\u78f7\u50ac\u5316\u5242\u50ac\u53163-\u53e0\u6c2e\u4e19\u57fa\u831a\u4e8c\u916e\u7684\u4e0d\u5bf9\u79f0Staudinger-aza-Wittig\u53cd\u5e94\uff0c\u6784\u5efa\u516d\u5143\u6742\u73af\u80fa\u5316\u5408\u7269(Scheme 1)\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e Catalytic Asymmetric Staudinger\u2212aza-Wittig Reaction for the Synthesis of Heterocyclic Amines Cai, L.; Zhang, K.; Chen, S.; Lepage, R. J.; Houk, K. N.; Krenske, E. H.; Kwon, O. * J. Am. Chem. Soc. 2019, 141, 9537-9542 DOI: 10.1021\/jacs.9b04803 \u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd\uff1a \u7814\u7a76\u8005\uff1aOhyun Kwon\u6559\u6388 \u7814\u7a76\u8005\u7ecf\u5386\uff1a 1991\uff0cB.S.\uff0cSeoul National University 1993\uff0cM.S.\uff0c Seoul National University 1998\uff0cPh.D.\uff0cColumbia University 1998\uff0cHoward Hughes Postdoctoral Fellow\uff0cHarvard University 2001\uff0cassistant professor\uff0cUCLA 2005\uff0cmember of the Molecular Biology Institute (MBI) and UCLA Jonsson Comprehensive Cancer Center (JCCC) \u8363\u8a89\u5956\u9879 Amgen Young Investigator&#8217;s Award Synthesis and Synlett Thieme Journal Award UCLA Faculty Career Development Award Glenn T. 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