{"id":25943,"date":"2019-07-09T08:00:45","date_gmt":"2019-07-09T00:00:45","guid":{"rendered":"\/\/www.gsbet888.com\/?p=25943"},"modified":"2019-07-09T09:19:30","modified_gmt":"2019-07-09T01:19:30","slug":"%e5%ae%98%e8%83%bd%e5%9b%a2%e7%9a%84%e8%bd%ac%e5%8c%96-%e9%86%87%e7%9a%84%e5%8f%8d%e5%ba%94%ef%bc%88%e4%b8%89%ef%bc%89%e7%a2%98%e4%bb%a3%e3%80%81%e7%a3%ba%e5%8c%96%e5%92%8c%e7%a3%b7","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/%e5%8f%96%e4%bb%a3%e5%8f%8d%e5%ba%94\/2019\/07\/%e5%ae%98%e8%83%bd%e5%9b%a2%e7%9a%84%e8%bd%ac%e5%8c%96-%e9%86%87%e7%9a%84%e5%8f%8d%e5%ba%94%ef%bc%88%e4%b8%89%ef%bc%89%e7%a2%98%e4%bb%a3%e3%80%81%e7%a3%ba%e5%8c%96%e5%92%8c%e7%a3%b7.html","title":{"rendered":"\u5b98\u80fd\u56e2\u7684\u8f6c\u5316\u2014\u2014\u9187\u7684\u53cd\u5e94\uff08\u4e09\uff09\u7898\u4ee3\u3001\u78fa\u5316\u548c\u78f7\u9178\u916f\u5316"},"content":{"rendered":"

\u672c\u6587\u4f5c\u8005\u5b59\u82cf\u8d5f<\/p>\n

\u4e00\u3001\u7898\u4ee3\u53cd\u5e94\"\"<\/a><\/h4>\n

\u8fd9\u79cd\u7ec4\u5408\u662f\u6700\u5e38\u7528\u7684\u7898\u4ee3\u7684\u65b9\u6cd5\uff0c\u4f8b\u5982[1]<\/sup>\uff1a<\/p>\n

\"\"<\/a><\/p>\n

\u6b64\u65b9\u6cd5\u4e5f\u5e38\u7528\u4e8e\u7cd6\u5316\u5b66\u4e2d\uff1a<\/p>\n

\"\"<\/a><\/p>\n

\u6b64\u5916\u8fd8\u6709\u4e00\u4e9b\u4e0d\u592a\u5e38\u7528\u7684\u65b9\u6cd5\uff1a<\/p>\n

\"\"<\/a><\/p>\n

\u4e8c\u3001\u78fa\u5316\u53cd\u5e94<\/h4>\n

\u5728\u6709\u673a\u5408\u6210\u4e2d\uff0c\u78fa\u9178\u916f\u4f5c\u4e3a\u6548\u679c\u8fd8\u4e0d\u9519\u7684\u79bb\u53bb\u57fa\u56e2\uff0c\u5728\u6709\u673a\u5408\u6210\u4e2d\u5e38\u4f5c\u4e3a\u5364\u7d20\u539f\u5b50\u7684\u66ff\u4ee3\uff0c\u5b9e\u73b0\u4e00\u7cfb\u5217\u7684\u8f6c\u5316\uff0c\u8f83\u5e38\u7528\u7684\u78fa\u9178\u916f\u7684\u6709\u7532\u78fa\u9178\u916f (Ms)\uff0c\u4e09\u6c1f\u7532\u78fa\u9178\u916f (Tf)\u548c\u5bf9\u82ef\u7532\u78fa\u9178\u916f (Ts)\uff1a<\/p>\n

\"\"<\/a><\/p>\n

\u79bb\u53bb\u57fa\u56e2\u7684\u79bb\u53bb\u80fd\u529b\uff1aROTf >> ROMs ~ ROTs ~ RI > RBr > RCl<\/p>\n

\"\"<\/a><\/p>\n

\u5176\u4e2d\uff0c(a) \u662f\u6700\u5e38\u7528\u7684Ts\u78fa\u5316\u7684\u65b9\u6cd5\uff0c\u4f46\u662f\u70ef\u4e19\u57fa\u548c\u4e09\u7ea7\u70f7\u57fa\u7094\u975e\u5e38\u4e0d\u7a33\u5b9a\uff0c\u5e76\u4e14\u6d3b\u6027\u975e\u5e38\u9ad8\uff0c\u56e0\u6b64\u6bd4\u8f83\u96be\u5236\u5907\u63d0\u7eaf\u5f97\u5230\u7eaf\u51c0\u7269\uff1b(b) \u662fMs\u78fa\u5316\u6700\u5e38\u7528\u7684\u65b9\u6cd5\uff1b(c) \u7528\u4e8e\u5927\u4f4d\u963b\u7684\u9187\u5316\u5408\u7269\uff1b(d) \u9014\u5f84\u4e2d\u4f7f\u7528\u4e09\u6c1f\u7532\u78fa\u9178\u9150\u6765\u5236\u5907Tf\u78fa\u9178\u916f\uff0c\u4e8c\u7ea7\u9187\u7684\u53cd\u5e94\u6027\u66f4\u597d\uff0c\u53c8\u56e0\u4e3a\u53ef\u4ee5\u53d1\u751fSN<\/sub><\/em>2\uff0c\u56e0\u6b64\u5728\u7cd6\u5316\u5b66\u4e2d\u975e\u5e38\u5e38\u7528\u3002<\/p>\n

\u8fd9\u91cc\u662f\u4e24\u4e2a\u4f8b\u5b50\uff1a<\/p>\n

(1) \u90bb\u4e8c\u9187\u7684\u78fa\u5316-\u53d6\u4ee3\u53cd\u5e94[2]<\/sup>\uff1a<\/p>\n

\"\"<\/a><\/p>\n

(2) \u4e8c\u7ea7\u9187\u7684\u53cd\u5e94[3]<\/sup>\uff1a<\/p>\n

\"\"<\/a><\/p>\n

\u4e09\u3001\u78f7\u9178\u916f\u5316\u53cd\u5e94<\/h4>\n

\u78f7\u9178\u916f\u5728\u6709\u673a\u5408\u6210\u4e2d\u4e0d\u662f\u975e\u5e38\u5e38\u7528\uff0c\u4f46\u662f\u6709\u65f6\u5374\u662f\u975e\u5e38\u6709\u6548\u7684\u53cd\u5e94\u8bd5\u5242\uff0c\u4f8b\u5982Newhouse\u8bfe\u9898\u7ec4\u5f00\u53d1\u7684\u73af\u916e\u7684\u8131\u6c22\u53cd\u5e94[4]<\/sup>\uff1a<\/p>\n

\"\"<\/a><\/p>\n

\u4f46\u662f\u78f7\u9178\u916f\u7684\u5408\u6210\u662f\u5f88\u7b80\u5355\u7684\uff1a<\/p>\n

\"\"<\/a><\/p>\n

\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u78f7\u7684\u624b\u6027\u4f1a\u53d1\u751f\u7ffb\u8f6c\u3002<\/p>\n

\u56db\u3001\u4f4e\u805a\u6838\u82f7\u9178\u7684\u5408\u6210(oligonucleotide synthesis) [5, 6]<\/sup><\/h4>\n

\u5728\u4f4e\u805a\u6838\u82f7\u9178\u7684\u5408\u6210\u7814\u7a76\u521d\u671f\uff0c\u78f7\u5316\u5408\u7269\u662f\u5176\u7814\u7a76\u7684\u6838\u5fc3\u3002\u5176\u4e2d\u4e00\u4e2a\u975e\u5e38\u4e3b\u8981\u7684\u95ee\u9898\u5c31\u662f\u5206\u5b50\u4e2dP-O–<\/sup>\u7684\u7ed3\u6784\u7684\u5bfc\u81f4\u53cd\u5e94\u7684\u9009\u62e9\u6027\u95ee\u9898\u3002\u8fd9\u4e2a\u95ee\u9898\u4e5f\u5bfc\u81f4\u4e86\u540e\u6765\u7684\u78f7\u9178\u57fa\u56e2\u9009\u62e9\u6027\u6d3b\u5316\u7684\u95ee\u9898\u3002<\/p>\n

\u7136\u800c\uff0c\u5728\u6b64\u4e4b\u540eMarrin Carruthers\u5f00\u53d1\u4e86\u4e00\u79cd\u4e9a\u78f7\u9170\u80fa\u7684\u65b9\u6cd5\u53ef\u4ee5\u89e3\u51b3\u4ee5\u4e0a\u7684\u96be\u9898\u3002\u4e9a\u78f7\u9170\u80fa\u662f\u4e00\u79cd\u5f88\u7a33\u5b9a\u7684\u78f7\u9178\u5316\u8bd5\u5242\u3002\u800c\u5230\u4e86\u4eca\u5929\uff0c\u8fd9\u7c7b\u53cd\u5e94\u5e38\u5e38\u4ee5\u56fa\u76f8\u53cd\u5e94\u7684\u5f62\u5f0f\u5728\u7845\u80f6\u4e0a\u8fdb\u884c\u3002\u5176\u4e2d\uff0c\u817a\u560c\u5464\u6838\u82f7\u548c\u80de\u5627\u5576\u4e0a\u7684\u6c28\u57fa\u4f7f\u7528\u82ef\u57fa\u4f5c\u4e3a\u4fdd\u62a4\u57fa\uff0c\u9e1f\u560c\u5464\u6838\u82f7\u4e0a\u7684\u6c28\u57fa\u53ef\u4f7f\u7528\u5f02\u4e19\u57fa\u4fdd\u62a4\uff0c\u800c\u80f8\u817a\u5627\u5576\u7684\u6c28\u57fa\u5219\u4e0d\u9700\u8981\u4fdd\u62a4\u57fa\u3002<\/p>\n

Carruthers\u5f00\u53d1\u7684\u65b9\u6cd5\u57fa\u672c\u5982\u4e0b\uff1a<\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

RE<\/strong>FERENCES<\/strong><\/h4>\n
    \n
  1. J. Am. Chem. Soc.<\/em>1999, 7423-7424, DOI: 10.1021\/ja991538b<\/a><\/li>\n
  2. Org. Lett.<\/em>1999, 11, 71-74,DOI: 10.1021\/ol9905506<\/a><\/li>\n
  3. Org. Lett.<\/em>1999, 13, 499-502, DOI: 10.1021\/ol990102y<\/a><\/li>\n
  4. Org. Lett<\/em>. 2018<\/strong>, 20<\/em>, 684\u2013687, DOI: acs.orglett.7b03818<\/a><\/li>\n
  5. Science<\/em> 1985 230 281, DOI: 1126\/science.3863253<\/li>\n
  6. Tetrahedron<\/em> 1992, 48, 2223, DOI: 1016\/S0040-4020(01)88752-4<\/a><\/li>\n<\/ol>\n

    \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\u5b59\u82cf\u8d5f \u4e00\u3001\u7898\u4ee3\u53cd\u5e94 \u8fd9\u79cd\u7ec4\u5408\u662f\u6700\u5e38\u7528\u7684\u7898\u4ee3\u7684\u65b9\u6cd5\uff0c\u4f8b\u5982[1]\uff1a \u6b64\u65b9\u6cd5\u4e5f\u5e38\u7528\u4e8e\u7cd6\u5316\u5b66\u4e2d\uff1a \u6b64\u5916\u8fd8\u6709\u4e00\u4e9b\u4e0d\u592a\u5e38\u7528\u7684\u65b9\u6cd5\uff1a \u4e8c\u3001\u78fa\u5316\u53cd\u5e94 \u5728\u6709\u673a\u5408\u6210\u4e2d\uff0c\u78fa\u9178\u916f\u4f5c\u4e3a\u6548\u679c\u8fd8\u4e0d\u9519\u7684\u79bb\u53bb\u57fa\u56e2\uff0c\u5728\u6709\u673a\u5408\u6210\u4e2d\u5e38\u4f5c\u4e3a\u5364\u7d20\u539f\u5b50\u7684\u66ff\u4ee3\uff0c\u5b9e\u73b0\u4e00\u7cfb\u5217\u7684\u8f6c\u5316\uff0c\u8f83\u5e38\u7528\u7684\u78fa\u9178\u916f\u7684\u6709\u7532\u78fa\u9178\u916f (Ms)\uff0c\u4e09\u6c1f\u7532\u78fa\u9178\u916f (Tf)\u548c\u5bf9\u82ef\u7532\u78fa\u9178\u916f (Ts)\uff1a \u79bb\u53bb\u57fa\u56e2\u7684\u79bb\u53bb\u80fd\u529b\uff1aROTf >> ROMs ~ ROTs ~ RI > RBr > RCl \u5176\u4e2d\uff0c(a) \u662f\u6700\u5e38\u7528\u7684Ts\u78fa\u5316\u7684\u65b9\u6cd5\uff0c\u4f46\u662f\u70ef\u4e19\u57fa\u548c\u4e09\u7ea7\u70f7\u57fa\u7094\u975e\u5e38\u4e0d\u7a33\u5b9a\uff0c\u5e76\u4e14\u6d3b\u6027\u975e\u5e38\u9ad8\uff0c\u56e0\u6b64\u6bd4\u8f83\u96be\u5236\u5907\u63d0\u7eaf\u5f97\u5230\u7eaf\u51c0\u7269\uff1b(b) \u662fMs\u78fa\u5316\u6700\u5e38\u7528\u7684\u65b9\u6cd5\uff1b(c) \u7528\u4e8e\u5927\u4f4d\u963b\u7684\u9187\u5316\u5408\u7269\uff1b(d) \u9014\u5f84\u4e2d\u4f7f\u7528\u4e09\u6c1f\u7532\u78fa\u9178\u9150\u6765\u5236\u5907Tf\u78fa\u9178\u916f\uff0c\u4e8c\u7ea7\u9187\u7684\u53cd\u5e94\u6027\u66f4\u597d\uff0c\u53c8\u56e0\u4e3a\u53ef\u4ee5\u53d1\u751fSN2\uff0c\u56e0\u6b64\u5728\u7cd6\u5316\u5b66\u4e2d\u975e\u5e38\u5e38\u7528\u3002 \u8fd9\u91cc\u662f\u4e24\u4e2a\u4f8b\u5b50\uff1a (1) \u90bb\u4e8c\u9187\u7684\u78fa\u5316-\u53d6\u4ee3\u53cd\u5e94[2]\uff1a (2) \u4e8c\u7ea7\u9187\u7684\u53cd\u5e94[3]\uff1a \u4e09\u3001\u78f7\u9178\u916f\u5316\u53cd\u5e94 \u78f7\u9178\u916f\u5728\u6709\u673a\u5408\u6210\u4e2d\u4e0d\u662f\u975e\u5e38\u5e38\u7528\uff0c\u4f46\u662f\u6709\u65f6\u5374\u662f\u975e\u5e38\u6709\u6548\u7684\u53cd\u5e94\u8bd5\u5242\uff0c\u4f8b\u5982Newhouse\u8bfe\u9898\u7ec4\u5f00\u53d1\u7684\u73af\u916e\u7684\u8131\u6c22\u53cd\u5e94[4]\uff1a \u4f46\u662f\u78f7\u9178\u916f\u7684\u5408\u6210\u662f\u5f88\u7b80\u5355\u7684\uff1a \u53cd\u5e94\u8fc7\u7a0b\u4e2d\u78f7\u7684\u624b\u6027\u4f1a\u53d1\u751f\u7ffb\u8f6c\u3002 \u56db\u3001\u4f4e\u805a\u6838\u82f7\u9178\u7684\u5408\u6210(oligonucleotide synthesis) [5, 6] \u5728\u4f4e\u805a\u6838\u82f7\u9178\u7684\u5408\u6210\u7814\u7a76\u521d\u671f\uff0c\u78f7\u5316\u5408\u7269\u662f\u5176\u7814\u7a76\u7684\u6838\u5fc3\u3002\u5176\u4e2d\u4e00\u4e2a\u975e\u5e38\u4e3b\u8981\u7684\u95ee\u9898\u5c31\u662f\u5206\u5b50\u4e2dP-O–\u7684\u7ed3\u6784\u7684\u5bfc\u81f4\u53cd\u5e94\u7684\u9009\u62e9\u6027\u95ee\u9898\u3002\u8fd9\u4e2a\u95ee\u9898\u4e5f\u5bfc\u81f4\u4e86\u540e\u6765\u7684\u78f7\u9178\u57fa\u56e2\u9009\u62e9\u6027\u6d3b\u5316\u7684\u95ee\u9898\u3002 \u7136\u800c\uff0c\u5728\u6b64\u4e4b\u540eMarrin Carruthers\u5f00\u53d1\u4e86\u4e00\u79cd\u4e9a\u78f7\u9170\u80fa\u7684\u65b9\u6cd5\u53ef\u4ee5\u89e3\u51b3\u4ee5\u4e0a\u7684\u96be\u9898\u3002\u4e9a\u78f7\u9170\u80fa\u662f\u4e00\u79cd\u5f88\u7a33\u5b9a\u7684\u78f7\u9178\u5316\u8bd5\u5242\u3002\u800c\u5230\u4e86\u4eca\u5929\uff0c\u8fd9\u7c7b\u53cd\u5e94\u5e38\u5e38\u4ee5\u56fa\u76f8\u53cd\u5e94\u7684\u5f62\u5f0f\u5728\u7845\u80f6\u4e0a\u8fdb\u884c\u3002\u5176\u4e2d\uff0c\u817a\u560c\u5464\u6838\u82f7\u548c\u80de\u5627\u5576\u4e0a\u7684\u6c28\u57fa\u4f7f\u7528\u82ef\u57fa\u4f5c\u4e3a\u4fdd\u62a4\u57fa\uff0c\u9e1f\u560c\u5464\u6838\u82f7\u4e0a\u7684\u6c28\u57fa\u53ef\u4f7f\u7528\u5f02\u4e19\u57fa\u4fdd\u62a4\uff0c\u800c\u80f8\u817a\u5627\u5576\u7684\u6c28\u57fa\u5219\u4e0d\u9700\u8981\u4fdd\u62a4\u57fa\u3002 Carruthers\u5f00\u53d1\u7684\u65b9\u6cd5\u57fa\u672c\u5982\u4e0b\uff1a REFERENCES J. Am. Chem. Soc.1999, 7423-7424, DOI: 10.1021\/ja991538b Org. Lett.1999, 11, 71-74,DOI: 10.1021\/ol9905506 Org. Lett.1999, 13, 499-502, DOI: 10.1021\/ol990102y Org. Lett. 2018, 20, 684\u2013687, DOI: acs.orglett.7b03818 Science 1985 230 281, DOI: 1126\/science.3863253 Tetrahedron 1992, 48, 2223, DOI: 1016\/S0040-4020(01)88752-4 \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01","protected":false},"author":8,"featured_media":25967,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[16],"tags":[2416,2418,2417,41],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/07\/d82d4107ea93794157af0abe6c56556d-1.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-6Kr","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/25943"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=25943"}],"version-history":[{"count":5,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/25943\/revisions"}],"predecessor-version":[{"id":25968,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/25943\/revisions\/25968"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/25967"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=25943"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=25943"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=25943"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}