{"id":26077,"date":"2019-07-23T08:00:17","date_gmt":"2019-07-23T00:00:17","guid":{"rendered":"\/\/www.gsbet888.com\/?p=26077"},"modified":"2019-07-19T21:22:56","modified_gmt":"2019-07-19T13:22:56","slug":"%e7%a2%b3%e7%a2%b3%e9%94%ae%e7%9a%84%e5%bd%a2%e6%88%90%ef%bc%9a%e8%bf%87%e6%b8%a1%e9%87%91%e5%b1%9e%e5%82%ac%e5%8c%96%e7%9a%84%e8%8a%b3%e7%83%83%e5%92%8c%e7%83%af%e7%83%83%e7%9a%84%e5%81%b6%e8%81%94-2","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2019\/07\/%e7%a2%b3%e7%a2%b3%e9%94%ae%e7%9a%84%e5%bd%a2%e6%88%90%ef%bc%9a%e8%bf%87%e6%b8%a1%e9%87%91%e5%b1%9e%e5%82%ac%e5%8c%96%e7%9a%84%e8%8a%b3%e7%83%83%e5%92%8c%e7%83%af%e7%83%83%e7%9a%84%e5%81%b6%e8%81%94-2.html","title":{"rendered":"\u78b3\u78b3\u952e\u7684\u5f62\u6210\uff1a\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u7684\u82b3\u70c3\u548c\u70ef\u70c3\u7684\u5076\u8054\u53cd\u5e94 \u7b2c\u4e00\u90e8\u5206 Heck\u53cd\u5e94\uff08\u4e8c\uff09\uff1a\u5206\u5b50\u95f4\u7684Heck\u5076\u8054\u7684\u5e94\u7528"},"content":{"rendered":"

\u672c\u6587\u4f5c\u8005 \u5b59\u82cf\u8d5f<\/p>\n

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\uff083\uff09\u53cc\u91cd\u533a\u57df\u9009\u62e9\u7684\u4f8b\u5b50\uff1a ref.3\"\"<\/a><\/p>\n

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\uff084\uff09 ref.4,5\"\"<\/a><\/p>\n

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\uff085\uff09\u78b1\u7684\u5f71\u54cd\uff1a ref.6\"\"<\/a><\/p>\n

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\uff086\uff09\u6c2f\u4ee3\u82ef\u5728\u5ba4\u6e29\u4e0b\u7684\u5076\u8054\u53cd\u5e94\uff1a ref.7\"\"<\/a><\/p>\n

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\uff087\uff09\u4e0d\u5bf9\u79f0\u7684Heck\u5076\u8054\uff1a ref.8<\/p>\n

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\u5206\u5b50\u5185\u7684\u4e0d\u5bf9\u79f0Heck\u5076\u8054\uff1aref. 10\"\"<\/a><\/p>\n

\uff088\uff09\u533a\u57df\u9009\u62e9\u6027\u7684\u63a7\u5236\uff1a ref.11\"\"<\/a><\/p>\n

A<\/em><\/strong>\u4fa7\u7684\u53cd\u5e94\u662f\u4e00\u822c\u7684\u6761\u4ef6\uff0c\u4f7f\u7528\u7684\u53cc\u78f7\u914d\u4f53\uff0c\u6700\u540e\u901a\u8fc7\u6c34\u89e3\u540e\u5f97\u5230\u7684\u662f\u7532\u57fa\u916e\u5316\u5408\u7269\uff1bB<\/em><\/strong>\u4fa7\u7684\u53cd\u5e94\u4e2d\uff0c\u53cd\u5e94\u6761\u4ef6\u4e0b\u4f1a\u4ea7\u751f\u80fa-Pd\u7edc\u5408\uff0c\u56e0\u6b64\u503e\u5411\u4e8e\u751f\u6210\u03b2-\u82b3\u57fa\u5316\u7684\u4ea7\u7269\u3002<\/p>\n

\uff089\uff09\u7fb0\u57fa\u7684Heck\u5076\u8054\uff1a ref.12\"\"<\/a><\/p>\n

\u53ef\u80fd\u7684\u53cd\u5e94\u673a\u7406\uff1a\"\"<\/a><\/p>\n

REFERENCES<\/strong><\/h4>\n
    \n
  1. Tetrahedron<\/em> 1981, 37, 4035\u20134040. DOI: 1016\/S0040-4020(01)93278-8<\/a><\/li>\n
  2. J. Am. Chem. Soc.<\/em>, 1993, 115<\/em> (23), pp 11028\u201311029, DOI: 10.1021\/ja00076a086<\/a><\/li>\n
  3. J. Org. Chem.<\/em>, 1979, 44<\/em> (23), pp 4078\u20134080, DOI: 10.1021\/jo01337a012<\/a><\/li>\n
  4. Tetrahedron Lett., <\/em>1988, 29, 905, DOI: 1016\/S0040-4039(00)82478-8<\/a><\/li>\n
  5. Tetrahedron Lett.,<\/em> 1985, 26, 2667, DOI:1016\/S0040-4039(00)98131-0<\/a><\/li>\n
  6. Tetrahedron Lett.,<\/em> 1995, 36, 6287, DOI:1016\/0040-4039(95)01294-R<\/a><\/li>\n
  7. J. Am. Chem. Soc.<\/em>, 2001, 123<\/em> (29), pp 6989\u20137000, DOI: 10.1021\/ja010988c<\/a><\/li>\n
  8. Chem. Rev.<\/em>, 2003, 103<\/em> (8), pp 2945\u20132964, DOI: 10.1021\/cr020039h<\/a><\/li>\n
  9. Angew. Chem. Int. Ed. Engl.,<\/em> 1996, 35, 200, DOI:10.1002\/anie.199602001<\/a><\/li>\n
  10. J. Am. Chem. Soc.<\/em>, 2003, 125<\/em> (20), pp 6261\u20136271, DOI: 10.1021\/ja034525d<\/a><\/li>\n
  11. J. Med. Chem.<\/em>, 1999, 42<\/em> (20), pp 4054\u20134061, DOI: 10.1021\/jm991054q<\/a><\/li>\n
  12. J. Org. Chem.<\/em>, 1990, 55<\/em> (10), pp 3004\u20133005, DOI: 10.1021\/jo00297a009<\/a><\/li>\n<\/ol>\n

    \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005 \u5b59\u82cf\u8d5f \uff081\uff09Heck\u53cd\u5e94\u5bf9\u5927\u73af\u5408\u6210\u7684\u53cd\u5e94\u975e\u5e38\u6709\u7528\uff1a ref.1 \uff082\uff09\u4e94\u5143\u73af\u5230\u4e03\u5143\u73af\u5e38\u4f1a\u5f97\u5230exo-\u73af\u5316\u7684\u4ea7\u7269\uff1a ref.2 \uff083\uff09\u53cc\u91cd\u533a\u57df\u9009\u62e9\u7684\u4f8b\u5b50\uff1a ref.3 \u5728\u4ee5\u4e0a\u7684\u8fd9\u4e2a\u4f8b\u5b50\u4e2d\uff0c\u5b9e\u73b0\u4e86\u53cc\u952e\u7684\u533a\u57df\u9009\u62e9\u6027\u548c\u53cc\u5364\u4ee3\u82b3\u70c3\u7684\u5143\u7d20\u9009\u62e9\u6027\uff0c\u8fd9\u662f\u56e0\u4e3a\u7898\u7684\u6d3b\u6027\u8f83\u6eb4\u66f4\u9ad8\u3002\u5176\u4e2d\uff0cPd(II)\u5230Pd(0)\u7684\u8fc7\u7a0b\u662f\u901a\u8fc7TEA\u7684\u4f5c\u7528\u5b9e\u73b0\u7684\uff1a \uff084\uff09 ref.4,5 \u8fd9\u4e2a\u53cd\u5e94\u7684\u4e2d\u95f4\u4f53\u6709\u4e24\u4e2a\u03b2-H\uff0c\u4f46\u662f\u548cPd\u7684cis-H\u5374\u53ea\u6709\u4e00\u4e2a\uff0c\u56e0\u6b64\u5728\u53d1\u751f\u8fd8\u539f\u6d88\u9664\u7684\u65f6\u5019\uff0c\u53ea\u4f1a\u6709\u4e00\u79cd\u4ea7\u7269\u4e13\u4e00\u7684\u751f\u6210\uff0c\u597d\u4f3c\u53d1\u751f\u4e86\u53cc\u952e\u7684\u8fc1\u79fb\u3002\u8fd9\u4e2a\u53cd\u5e94\u672a\u4f7f\u7528\u914d\u4f53\uff0c\u800c\u662f\u7528\u5b63\u94f5\u76d0\u4f5c\u4e3a\u4ee3\u66ff\uff0c\u8fd9\u4e5f\u88ab\u53eb\u505aJeffery-Heck\u53cd\u5e94\uff0c\u5728\u8fd9\u4e9b\u6761\u4ef6\u4e0b\uff0c\u53cd\u5e94\u5728DMF\u6216DMSO\u4e2d\u5ba4\u6e29\u4e0b\u5373\u53ef\u53d1\u751f\uff0c\u5b63\u94f5\u76d0\u53ef\u80fd\u662f\u901a\u8fc7\u8fd8\u539f\u6d88\u9664\u5c06Pd\u8bd5\u5242\u8fd8\u539f\u52300\u4ef7\u7684\u8bd5\u5242\uff0c\u5e76\u4e14\u6291\u5236\u4e86\u70ef\u70c3\u7684\u5f02\u6784\u5316\u4f5c\u7528\u3002 \uff085\uff09\u78b1\u7684\u5f71\u54cd\uff1a ref.6 \u56e0\u4e3a\u78b1\u7684\u6027\u8d28\u7684\u4e0d\u540c\uff0c\u53d1\u751f\u8fd8\u539f\u6d88\u9664\u7684\u6c22\u662f\u4e0d\u540c\u7684\uff0c\u5bf9\u4e8e\u751f\u6210\u916e\u4ea7\u7269\u7684\u8def\u7ebf\uff0c\u4e2d\u95f4\u4f53\u662f\u901a\u8fc7\u6d88\u9664\u6c22\u751f\u6210\u70ef\u9187\u4e4b\u540e\u5f02\u6784\u5316\u5f97\u5230\u916e\u7684\u3002 \uff086\uff09\u6c2f\u4ee3\u82ef\u5728\u5ba4\u6e29\u4e0b\u7684\u5076\u8054\u53cd\u5e94\uff1a ref.7 \u8fd9\u79cd\u914d\u4f53\u662f\u5f53\u65f6\u672a\u66fe\u62a5\u9053\u8fc7\u7684\u65b0\u914d\u4f53\uff0c\u56e0\u4e3a\u8fd9\u79cd\u78f7\u914d\u4f53\u7684\u4f53\u79ef\u975e\u5e38\u5927\uff0c\u56e0\u6b64\u53ef\u4ee5\u52a0\u901f\u6c2f\u82ef\u5316\u5408\u7269\u6c27\u5316\u52a0\u6210\u6b65\u9aa4\uff0c\u56e0\u6b64\u53ef\u4ee5\u5b9e\u73b0\u5ba4\u6e29\u4e0b\u7684\u5076\u8054\u53cd\u5e94\u3002 \uff087\uff09\u4e0d\u5bf9\u79f0\u7684Heck\u5076\u8054\uff1a ref.8 \u5206\u5b50\u95f4\u7684\u4e0d\u5bf9\u79f0Heck\u5076\u8054\uff1aref. 9 \u5206\u5b50\u5185\u7684\u4e0d\u5bf9\u79f0Heck\u5076\u8054\uff1aref. 10 \uff088\uff09\u533a\u57df\u9009\u62e9\u6027\u7684\u63a7\u5236\uff1a ref.11 A\u4fa7\u7684\u53cd\u5e94\u662f\u4e00\u822c\u7684\u6761\u4ef6\uff0c\u4f7f\u7528\u7684\u53cc\u78f7\u914d\u4f53\uff0c\u6700\u540e\u901a\u8fc7\u6c34\u89e3\u540e\u5f97\u5230\u7684\u662f\u7532\u57fa\u916e\u5316\u5408\u7269\uff1bB\u4fa7\u7684\u53cd\u5e94\u4e2d\uff0c\u53cd\u5e94\u6761\u4ef6\u4e0b\u4f1a\u4ea7\u751f\u80fa-Pd\u7edc\u5408\uff0c\u56e0\u6b64\u503e\u5411\u4e8e\u751f\u6210\u03b2-\u82b3\u57fa\u5316\u7684\u4ea7\u7269\u3002 \uff089\uff09\u7fb0\u57fa\u7684Heck\u5076\u8054\uff1a ref.12 \u53ef\u80fd\u7684\u53cd\u5e94\u673a\u7406\uff1a REFERENCES Tetrahedron 1981, 37, 4035\u20134040. DOI: 1016\/S0040-4020(01)93278-8 J. Am. Chem. Soc., 1993, 115 (23), pp 11028\u201311029, DOI: 10.1021\/ja00076a086 J. Org. Chem., 1979, 44 (23), pp 4078\u20134080, DOI: 10.1021\/jo01337a012 Tetrahedron Lett., 1988, 29, 905, DOI: 1016\/S0040-4039(00)82478-8 Tetrahedron Lett., 1985, 26, 2667, DOI:1016\/S0040-4039(00)98131-0 Tetrahedron Lett., 1995, 36, 6287, DOI:1016\/0040-4039(95)01294-R J. Am. Chem. Soc., 2001, 123 (29), pp 6989\u20137000, DOI: 10.1021\/ja010988c Chem. Rev., 2003, 103 (8), pp 2945\u20132964, DOI: 10.1021\/cr020039h Angew. Chem. Int. Ed. Engl., 1996, 35, 200, DOI:10.1002\/anie.199602001 J. Am. Chem. Soc., […]","protected":false},"author":8,"featured_media":26075,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/07\/cover.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-6MB","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/26077"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=26077"}],"version-history":[{"count":3,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/26077\/revisions"}],"predecessor-version":[{"id":26221,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/26077\/revisions\/26221"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/26075"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=26077"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=26077"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=26077"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}