{"id":2825,"date":"2014-09-30T09:07:30","date_gmt":"2014-09-30T01:07:30","guid":{"rendered":"\/\/www.gsbet888.com\/?p=2825"},"modified":"2019-08-02T18:56:16","modified_gmt":"2019-08-02T10:56:16","slug":"post-2825","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/%e7%bc%a9%e5%90%88%e5%8f%8d%e5%ba%94\/2014\/09\/post-2825.html","title":{"rendered":"Petasis\u53cd\u5e94(Petasis Reaction)"},"content":{"rendered":"<ul>\n<li><strong>\u6982\u8981<\/strong><\/li>\n<\/ul>\n<p>\u8be5\u53cd\u5e94\u662f\u591a\u7ec4\u5206\u7f29\u5408\u53cd\u5e94\uff08Multicomponent Reaction\uff09\u4e2d\u7684\u4e00\u79cd\u3002<\/p>\n<p>\u8be5\u53cd\u5e94\u4e2d\u4f7f\u7528\u4e86\u5bf9\u6c34\/\u7a7a\u6c14\u7a33\u5b9a\u7684\u70ef\u57fa \u30fb\u82b3\u57fa\u787c\u9178\u4f5c\u4e3a\u7b2c\u4e94\uff0c\u5408\u6210\u4e86\u8bf8\u5982 \u03b1-\u6c28\u57fa\u9178\u548c \u03b2-\u6c28\u57fa\u9187\u8fd9\u6837\u7684\u5728\u5408\u6210\u5316\u5b66\u4e2d\u5341\u5206\u6709\u7528\u7684\u4ea7\u7269\u3002\u5728\u4f7f\u7528\u624b\u6027\u03b1-\u7f9f\u57fa\u919b\u4f5c\u4e3a\u5e95\u7269\u7684\u53cd\u5e94\u4e2d\uff0c\u53ef\u4ee5\u5f97\u5230\u9ad8\u7acb\u4f53\u9009\u62e9\u6027\u7684\u53cd\u5f0f \u03b2-\u6c28\u57fa\u9187\u3002<\/p>\n<p>\u8be5\u53cd\u5e94\u7684\u5b9e\u9a8c\u64cd\u4f5c\u7279\u522b\u5bb9\u6613\uff0c\u5728\u6eb6\u5242\u4e2d\uff08\u901a\u5e38\u662f\u4e59\u9187\uff09\uff0c\u628a\u787c\u9178\uff0c\u80fa\uff0c\u03b1-\u916e\u9178\uff08\u6216\u03b1-\u7f9f\u57fa\u919b\uff09\u6df7\u5408\u5ba4\u6e29\u6405\u62cc\u5373\u53ef\u3002<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u57fa\u672c\u6587\u732e<\/strong><\/li>\n<\/ul>\n<p>\u30fbPetasis, N. A.; Akritopoulou, I. <em>Tetrahedron Lett.<\/em> <strong>1993<\/strong>, <em>34<\/em>, 583. DOI: <a href=\"http:\/\/dx.doi.org\/10.1016\/S0040-4039(00)61625-8\">10.1016\/S0040-4039(00)61625-8<\/a><br \/>\n\u30fbPetasis, N. A.; Zavialov, I. A. <em>J. Am. Chem. Soc.<\/em> <strong>1997<\/strong>, <em>119<\/em>, 445. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ja963178n\">10.1021\/ja963178n<\/a><br \/>\n\u30fbPetasis, N. A.; Zavialov, I. A. <em>J. Am. Chem. Soc.<\/em> <strong>1998<\/strong>, <em>120<\/em>, 11798. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ja981075u\">10.1021\/ja981075u<\/a><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u53cd\u5e94\u673a\u7406<\/strong><\/li>\n<\/ul>\n<p>\u5728\u539f\u6587\u732e\u4e2d\uff0c\u6ca1\u6709\u6d89\u53ca\u5230\u5177\u4f53\u5bf9\u4e8e \u8be5\u53cd\u5e94\u7684\u53cd\u5e94\u673a\u7406\u7684\u63cf\u8ff0\uff0c\u4f46\u662f\u65e0\u4fdd\u62a4\u7684\u7fa7\u9178\u4e0e\u7f9f\u57fa\u662f\u4f7f\u5f97\u53cd\u5e94\u8fdb\u884c\u7684\u5fc5\u8981\u6761\u4ef6\u3002\u6216\u8bb8\u8fd9\u4e5f\u4ece\u4e00\u65b9\u9762\u8bc1\u660e\u4e86\u8be5\u53cd\u5e94\u662f\u7ecf\u7531\u70ef\u80fa\u79bb\u5b50\u4e0e\u787c\u9178\u76d0\u4e2d\u95f4\u4f53\u8fdb\u884c\u7684\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/09\/petasis_5.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2826\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/09\/petasis_5.gif\" alt=\"petasis_5\" width=\"402\" height=\"166\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/li>\n<\/ul>\n<p>\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u5f3a\u7684\u591a\u7ec4\u5206\u7f29\u5408\u53cd\u5e94\uff0c\u6700\u5927\u7684\u4f18\u70b9\u5c31\u662f\u53ef\u4ee5\u7528\u6765\u8fc5\u901f\u6784\u5efa\u591a\u6837\u6027\u7684\u5316\u5408\u7269\u5e93\u3002\u4e0b\u56fe\u662f\u7ed9\u51fa\u7684\u4e00\u4e2a\u8fd0\u7528Petasis\u53cd\u5e94\u7684\u5b9e\u4f8b\u3002[1]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/09\/petasis_2.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2827\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/09\/petasis_2.gif\" alt=\"petasis_2\" width=\"536\" height=\"109\" \/><\/a><\/p>\n<p>\u8fd0\u7528\u6709\u673a\u50ac\u5316\u5242\u8fdb\u884c\u7684\u4e0d\u5bf9\u79f0Petasis\u578b\u5076\u8054\u53cd\u5e94\u3002[2]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/09\/petasis_4.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2828\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/09\/petasis_4.gif\" alt=\"petasis_4\" width=\"408\" height=\"158\" \/><\/a><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/09\/petasis_6.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2829\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/09\/petasis_6.gif\" alt=\"petasis_6\" width=\"404\" height=\"78\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u5b9e\u9a8c\u6280\u5de7<\/strong><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u53c2\u8003\u6587\u732e<\/strong><\/li>\n<\/ul>\n[1] Kumagai, N.; Muncipinto, G.; Schreiber, S. L. <em>Angew. Chem. Int. Ed.<\/em> <strong>2006<\/strong>, <em>45<\/em>, 3635. doi:<a href=\"http:\/\/dx.doi.org\/10.1002\/ange.200600497\">10.1002\/ange.200600497<\/a><br \/>\n[2] (a) Yamaoka, Y.; Miyabe, H.; Takemoto, Y. <em>J. Am. Chem. Soc.<\/em> <strong>2007<\/strong>, <em>129<\/em>, 6686. DOI:<a href=\"http:\/\/dx.doi.org\/10.1021\/ja071470x\">10.1021\/ja071470x<\/a> (b) Lou, S.; Schaus, S. E. <em>J. Am. Chem. Soc.<\/em> <strong>2008<\/strong>, <em>130<\/em>, 6922. DOI:<a href=\"http:\/\/dx.doi.org\/10.1021\/ja8018934\">10.1021\/ja8018934<\/a><\/p>\n<p style=\"text-align: center\"><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<\/strong><a href=\"\/\/www.gsbet888.com\/\"><strong>Chem-Station\u5316\u5b66\u7a7a\u95f4<\/strong><\/a><strong>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/strong><\/p>\n<p>&nbsp; <\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 \u8be5\u53cd\u5e94\u662f\u591a\u7ec4\u5206\u7f29\u5408\u53cd\u5e94\uff08Multicomponent Reaction\uff09\u4e2d\u7684\u4e00\u79cd\u3002 \u8be5\u53cd\u5e94\u4e2d\u4f7f\u7528\u4e86\u5bf9\u6c34\/\u7a7a\u6c14\u7a33\u5b9a\u7684\u70ef\u57fa \u30fb\u82b3\u57fa\u787c\u9178\u4f5c\u4e3a\u7b2c\u4e94\uff0c\u5408\u6210\u4e86\u8bf8\u5982 \u03b1-\u6c28\u57fa\u9178\u548c \u03b2-\u6c28\u57fa\u9187\u8fd9\u6837\u7684\u5728\u5408\u6210\u5316\u5b66\u4e2d\u5341\u5206\u6709\u7528\u7684\u4ea7\u7269\u3002\u5728\u4f7f\u7528\u624b\u6027\u03b1-\u7f9f\u57fa\u919b\u4f5c\u4e3a\u5e95\u7269\u7684\u53cd\u5e94\u4e2d\uff0c\u53ef\u4ee5\u5f97\u5230\u9ad8\u7acb\u4f53\u9009\u62e9\u6027\u7684\u53cd\u5f0f \u03b2-\u6c28\u57fa\u9187\u3002 \u8be5\u53cd\u5e94\u7684\u5b9e\u9a8c\u64cd\u4f5c\u7279\u522b\u5bb9\u6613\uff0c\u5728\u6eb6\u5242\u4e2d\uff08\u901a\u5e38\u662f\u4e59\u9187\uff09\uff0c\u628a\u787c\u9178\uff0c\u80fa\uff0c\u03b1-\u916e\u9178\uff08\u6216\u03b1-\u7f9f\u57fa\u919b\uff09\u6df7\u5408\u5ba4\u6e29\u6405\u62cc\u5373\u53ef\u3002 &nbsp; \u57fa\u672c\u6587\u732e \u30fbPetasis, N. A.; Akritopoulou, I. Tetrahedron Lett. 1993, 34, 583. DOI: 10.1016\/S0040-4039(00)61625-8 \u30fbPetasis, N. A.; Zavialov, I. A. J. Am. Chem. Soc. 1997, 119, 445. DOI: 10.1021\/ja963178n \u30fbPetasis, N. A.; Zavialov, I. A. J. Am. Chem. Soc. 1998, 120, 11798. DOI: 10.1021\/ja981075u &nbsp; \u53cd\u5e94\u673a\u7406 \u5728\u539f\u6587\u732e\u4e2d\uff0c\u6ca1\u6709\u6d89\u53ca\u5230\u5177\u4f53\u5bf9\u4e8e \u8be5\u53cd\u5e94\u7684\u53cd\u5e94\u673a\u7406\u7684\u63cf\u8ff0\uff0c\u4f46\u662f\u65e0\u4fdd\u62a4\u7684\u7fa7\u9178\u4e0e\u7f9f\u57fa\u662f\u4f7f\u5f97\u53cd\u5e94\u8fdb\u884c\u7684\u5fc5\u8981\u6761\u4ef6\u3002\u6216\u8bb8\u8fd9\u4e5f\u4ece\u4e00\u65b9\u9762\u8bc1\u660e\u4e86\u8be5\u53cd\u5e94\u662f\u7ecf\u7531\u70ef\u80fa\u79bb\u5b50\u4e0e\u787c\u9178\u76d0\u4e2d\u95f4\u4f53\u8fdb\u884c\u7684\u3002 &nbsp; \u53cd\u5e94\u5b9e\u4f8b \u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u5f3a\u7684\u591a\u7ec4\u5206\u7f29\u5408\u53cd\u5e94\uff0c\u6700\u5927\u7684\u4f18\u70b9\u5c31\u662f\u53ef\u4ee5\u7528\u6765\u8fc5\u901f\u6784\u5efa\u591a\u6837\u6027\u7684\u5316\u5408\u7269\u5e93\u3002\u4e0b\u56fe\u662f\u7ed9\u51fa\u7684\u4e00\u4e2a\u8fd0\u7528Petasis\u53cd\u5e94\u7684\u5b9e\u4f8b\u3002[1] \u8fd0\u7528\u6709\u673a\u50ac\u5316\u5242\u8fdb\u884c\u7684\u4e0d\u5bf9\u79f0Petasis\u578b\u5076\u8054\u53cd\u5e94\u3002[2] &nbsp; &nbsp; \u5b9e\u9a8c\u6b65\u9aa4 &nbsp; \u5b9e\u9a8c\u6280\u5de7 &nbsp; \u53c2\u8003\u6587\u732e [1] Kumagai, N.; Muncipinto, G.; Schreiber, S. L. Angew. Chem. Int. Ed. 2006, 45, 3635. doi:10.1002\/ange.200600497 [2] (a) Yamaoka, Y.; Miyabe, H.; Takemoto, Y. J. Am. Chem. Soc. 2007, 129, 6686. DOI:10.1021\/ja071470x (b) Lou, S.; Schaus, S. E. J. Am. Chem. Soc. 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