{"id":28389,"date":"2019-09-06T08:00:46","date_gmt":"2019-09-06T00:00:46","guid":{"rendered":"\/\/www.gsbet888.com\/?p=28389"},"modified":"2022-05-25T20:27:08","modified_gmt":"2022-05-25T12:27:08","slug":"%e5%ae%98%e8%83%bd%e5%9b%a2%e7%9a%84%e8%bd%ac%e5%8c%96-%e5%8d%a4%e5%8e%9f%e5%ad%90%e5%92%8c%e7%a3%ba%e9%85%b8%e9%85%af%e7%9a%84%e5%8f%8d%e5%ba%94-%e7%ac%ac%e4%ba%8c%e9%83%a8%e5%88%86","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/%e6%b6%88%e9%99%a4%e5%8f%8d%e5%ba%94\/2019\/09\/%e5%ae%98%e8%83%bd%e5%9b%a2%e7%9a%84%e8%bd%ac%e5%8c%96-%e5%8d%a4%e5%8e%9f%e5%ad%90%e5%92%8c%e7%a3%ba%e9%85%b8%e9%85%af%e7%9a%84%e5%8f%8d%e5%ba%94-%e7%ac%ac%e4%ba%8c%e9%83%a8%e5%88%86.html","title":{"rendered":"\u5b98\u80fd\u56e2\u7684\u8f6c\u5316\u2014\u2014\u5364\u539f\u5b50\u548c\u78fa\u9178\u916f\u7684\u53cd\u5e94 \u7b2c\u4e8c\u90e8\u5206 \u6d88\u9664\u53cd\u5e94\uff08\u4e00\uff09"},"content":{"rendered":"<p><strong>\u672c\u6587\u4f5c\u8005\uff1a\u5b59\u82cf\u8d5f<\/strong><\/p>\n<p>\u5364\u539f\u5b50\u548c\u78fa\u9178\u916f\u5728\u4e00\u5b9a\u7684\u6761\u4ef6\u4e0b\u90fd\u662f\u4e0d\u9519\u7684\u79bb\u53bb\u57fa\u56e2\uff0c\u9664\u4e86\u53d6\u4ee3\u53cd\u5e94\uff0c\u4ed6\u4eec\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u6d88\u9664\u53cd\u5e94\u7684\u5e95\u7269\u3002<\/p>\n<ol>\n<li>\u8102\u80aa\u5364\u4ee3\u70c3\u548c\u78fa\u9178\u916f<\/li>\n<\/ol>\n<p>(1) \u78b1\u4f5c\u7528\u4e0b\u7684\u6d88\u9664\u53cd\u5e94 (Zaitsev\u6d88\u9664)<\/p>\n<p>\u5bf9\u4e8e\u6d88\u9664\u53cd\u5e94\u6765\u8bf4\uff0c\u65e0\u8bba\u53cd\u5e94\u662f\u901a\u8fc7E1\uff0cE2\u673a\u7406\uff0c\u8fd8\u662fE1cb\u673a\u7406\uff0c\u90fd\u4f1a\u6bd4\u9884\u671f\u7684\u66f4\u96be\u53d1\u751f\uff0c\u5e76\u4e14\u4f1a\u4ea7\u751f\u591a\u79cd\u6d88\u9664\u5f02\u6784\u4f53\uff0c\u5305\u62ec\u533a\u57df\u5f02\u6784\u4f53\u548c<em>Z<\/em>\/<em>E<\/em>-\u5f02\u6784\u4f53\u3002\u901a\u5e38\u6765\u8bf4\u53cd\u5e94\u7684\u4ea7\u7269\u662f\u53d6\u4ee3\u8f83\u591a\u7684\u8f83\u7a33\u5b9a\u7684\u53cc\u952e\uff08Zaitsev\u89c4\u5219\uff09\uff0c\u6b64\u5916\u6d88\u9664\u4e5f\u4f1a\u548c\u4eb2\u6838\u53d6\u4ee3\u6709\u7ade\u4e89\u53cd\u5e94\u3002<\/p>\n<p>\u6d88\u9664\u53cd\u5e94\u4e00\u822c\u6709\u4e00\u4e0b\u51e0\u4e2a\u5f71\u54cd\u56e0\u7d20\uff1a<\/p>\n<ul style=\"list-style-type: circle;\">\n<li>\u53cd\u5e94\u5e95\u7269\uff1a<br \/>\na.1<sup>o<\/sup>\u548c2<sup>o<\/sup>\u5364\u4ee3\u70c3\u548c\u78fa\u9178\u916f\uff1aE2\u6d88\u9664\uff0c\u7acb\u4f53\u7279\u5f02\u6027\u7684\u53cd\u5f0f\u6d88\u9664\u8fc7\u7a0b\uff1b<br \/>\nb. 3<sup>o<\/sup>\uff0c\u82ef\u7532\u9187\u7c7b\uff1aE1\u6d88\u9664<br \/>\nc. \u03b1-\u5364\u4ee3\u7fb0\u57fa\u5316\u5408\u7269\uff1aE1cb\u6d88\u9664<\/li>\n<li>\u79bb\u53bb\u57fa\u56e2\uff1a\u7f9f\u57fa\u7684\u79bb\u53bb\u6027\u8d28\u8f83\u5dee\uff0c\u901a\u5e38\u5bf9\u4e8eE2\u548cE1cb\u53cd\u5e94\u4f1a\u9700\u8981\u6d3b\u5316\u8f6c\u5316\u6210\u5176\u4ed6\u7684\u57fa\u56e2\uff0c\u9178\u6027\u6761\u4ef6\u4e0b\u53ef\u4ee5\u8fdb\u884cE1\u6d88\u9664\u3002<\/li>\n<li>\u78b1\uff1a<br \/>\n\u5927\u4f53\u79ef\u7684\u78b1\u6709\u5229\u4e8e\u6d88\u9664\uff0c\u51cf\u5c11\u53d6\u4ee3\uff1b<br \/>\n\u5e38\u7528\u7684\u6709\uff1a<\/li>\n<\/ul>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/1-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-28390 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/1-2.png\" alt=\"\" width=\"710\" height=\"205\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/1-2.png 710w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/1-2-300x87.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/1-2-680x196.png 680w\" sizes=\"(max-width: 710px) 100vw, 710px\" \/><\/a><\/p>\n<p>\u51e0\u4e2a\u4f8b\u5b50\uff1a<\/p>\n<ol style=\"list-style-type: lower-alpha;\">\n<li>\u7898\u4ee3\u70c3\u7684\u6d88\u9664<sup>[1]<a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/2-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-28391 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/2-1.png\" alt=\"\" width=\"869\" height=\"193\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/2-1.png 869w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/2-1-300x67.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/2-1-768x171.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/2-1-680x151.png 680w\" sizes=\"(max-width: 869px) 100vw, 869px\" \/><\/a><\/sup>\u8fd9\u4e00\u6b65\u662fCorey\u8bfe\u9898\u7ec4\u7684prostaglandin\u7684\u5168\u5408\u6210\u7684\u4e2d\u7684\u91cd\u8981\u6b65\u9aa4\uff0c\u6d88\u9664\u53ea\u4f1a\u4ea7\u751f\u4e00\u79cd\u5f02\u6784\u4f53\uff0c\u9009\u62e9\u6027\u975e\u5e38\u597d\u3002<\/li>\n<li>\u6eb4\u4ee3\u70c3\u7684\u6d88\u9664<sup>[2]<a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/3-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-28400 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/3-1.png\" alt=\"\" width=\"804\" height=\"201\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/3-1.png 804w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/3-1-300x75.png 300w, 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srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/5-1.png 726w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/5-1-300x121.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/5-1-680x273.png 680w\" sizes=\"(max-width: 726px) 100vw, 726px\" \/><\/a><\/sup><\/p>\n<ol start=\"2\">\n<li>\u51e0\u79cd\u8131\u6c34\u53cd\u5e94<\/li>\n<\/ol>\n<p>(1) Grieco\u6d88\u9664\u53cd\u5e94<a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/6-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-28394 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/6-1.png\" alt=\"\" width=\"605\" height=\"125\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/6-1.png 605w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/6-1-300x62.png 300w\" sizes=\"(max-width: 605px) 100vw, 605px\" \/><\/a><\/p>\n<p>Grieco\u6d88\u9664\u53cd\u5e94\u4e2d\u4f7f\u7528\u5230\u4e86\u7852\u8bd5\u5242\u4f5c\u4e3a\u6c27\u5316\u5242\uff0c\u53cd\u5e94\u4e2d\u53d1\u751f\u7684\u662f\u70ed\u529b\u5b66\u6d88\u9664\uff0c\u53cd\u5e94\u5bf9\u4e8e1<sup>o<\/sup>\u9187\u6548\u679c\u975e\u5e38\u597d\u3002\u53cd\u5e94\u4e2d\u8bd5\u5242\u6d3b\u5316\u7684\u8fc7\u7a0b\u548cMitsunobu\u53cd\u5e94\u7c7b\u4f3c\uff0c\u6b64\u5916\u7b2c\u4e8c\u6b65\u7684\u6c27\u5316\u8fc7\u7a0b\u4e2d\u6c27\u5316\u5242\u7684\u9009\u62e9\u8303\u56f4\u5f88\u5e7f\uff0c\u5e38\u89c1\u7684\u6709H<sub>2<\/sub>O<sub>2<\/sub>\uff0c<em>m<\/em>-CPBA\uff0c\u7b49\u3002<\/p>\n<p>\u53cd\u5e94\u673a\u7406\uff1a<a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/7-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-28395 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/7-1.png\" alt=\"\" width=\"965\" height=\"456\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/7-1.png 965w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/7-1-300x142.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/7-1-768x363.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/7-1-680x321.png 680w\" sizes=\"(max-width: 965px) 100vw, 965px\" \/><\/a><\/p>\n<p>\u4f8b\u5982\uff1a<\/p>\n<ol style=\"list-style-type: lower-alpha;\">\n<li><sup>[4]<a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/8-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-28396 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/8-1.png\" alt=\"\" width=\"1081\" height=\"505\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/8-1.png 1081w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/8-1-300x140.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/8-1-768x359.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/8-1-680x318.png 680w\" sizes=\"(max-width: 1081px) 100vw, 1081px\" \/><\/a><\/sup><\/li>\n<\/ol>\n<p>\u7531\u4e8e\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u4f1a\u4ea7\u751f\u6c30\u8d1f\u79bb\u5b50\uff0c\u56e0\u6b64\u6709\u4e00\u5b9a\u7684\u51e0\u7387\u4f1a\u4ea7\u751f\u6c30\u4ee3\u7684\u526f\u4ea7\u7269\u3002<\/p>\n<p><sup>\u00a0 b. [5]<a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/9-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-28397 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/9-1.png\" alt=\"\" width=\"955\" height=\"229\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/9-1.png 955w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/9-1-300x72.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/9-1-768x184.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/9-1-680x163.png 680w\" sizes=\"(max-width: 955px) 100vw, 955px\" \/><\/a><\/sup><\/p>\n<p><sup>\u00a0 c. [6, 7]<a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/10-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-28398 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/10-1.png\" alt=\"\" width=\"913\" height=\"197\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/10-1.png 913w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/10-1-300x65.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/10-1-768x166.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/10-1-680x147.png 680w\" sizes=\"(max-width: 913px) 100vw, 913px\" \/><\/a><\/sup><\/p>\n<p>(2) Bogert-Cook Synthesis<sup>[8]<a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/11-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-28399 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/11-1.png\" alt=\"\" width=\"941\" height=\"182\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/11-1.png 941w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/11-1-300x58.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/11-1-768x149.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/11-1-680x132.png 680w\" sizes=\"(max-width: 941px) 100vw, 941px\" \/><\/a><\/sup><\/p>\n<p>\u8fd9\u4e2a\u53cd\u5e94\u662f\u7531Bogert\u8bfe\u9898\u7ec4\u548cCook\u8bfe\u9898\u7ec4\u51e0\u4e4e\u540c\u65f6\u57281993\u5e74\u62a5\u9053\u7684\uff0c\u53cd\u5e94\u8fc7\u7a0b\u662fGrignard\u8bd5\u5242\u548c\u916e\u53cd\u5e94\u751f\u6210\u5f97\u5230\u4e86\u4e00\u4e2a\u5e76\u4e09\u73af\u5316\u5408\u7269\u3002\u8fd9\u662f\u5728\u8d28\u5b50\u9178\u6761\u4ef6\u4e0b\u7f9f\u57fa\u8131\u6c34\u7ecf\u5386\u78b3\u6b63\u79bb\u5b50\u7684\u4e00\u4e2a\u5f88\u597d\u7684\u4f8b\u5b50\uff0c\u5f53\u53cd\u5e94\u4e2d\u95f4\u4f53\u548c\u4e00\u4e2a\u6e29\u548c\u7684\u8131\u6c34\u8bd5\u5242\u63a5\u89e6\u65f6\uff0c\u53cd\u5e94\u7684\u540e\u4e00\u9636\u6bb5\u8131\u6c34\u5f97\u5230\u53cc\u952e\uff0c\u5e76\u4e14\u6210\u73af\uff0c\u4f46\u662f\u6210\u73af\u8fc7\u7a0b\u4e2d\u5177\u4f53\u7684\u4f4d\u7f6e\u662f\u548c\u53cd\u5e94\u5e95\u7269\u6027\u8d28\u6709\u5173\u3002<\/p>\n<p><strong>REFERENCES<\/strong><\/p>\n<ol>\n<li><em>J. Am. Chem. Soc., <\/em>1973, 95, 20, 6832-6833, doi: <a href=\"https:\/\/doi.org\/10.1021\/ja00801a053\">10.1021\/ja00801a053<\/a><\/li>\n<li><em>J. Am. Chem. Soc., <\/em>2005, 127, 31, 11159-11175, doi: <a href=\"https:\/\/doi.org\/10.1021\/ja0529337\">10.1021\/ja0529337<\/a><\/li>\n<li><em>J. Am. Chem. Soc., <\/em>2012, 134, 34, 14232-14237, doi: 10.1021\/ja306323x<\/li>\n<li><em>J. Am. Chem. Soc., <\/em>2010, 13, 25, 1488-1489, 10.1021\/ja9104478<\/li>\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.tetlet.2004.03.085\"><em>Tetrahedron Lett.<\/em> 2004, 45, 3783.<\/a> doi :<a href=\"https:\/\/doi.org\/10.1016\/j.tetlet.2004.03.085\">1016\/j.tetlet.2004.03.085<\/a><\/li>\n<li><a href=\"http:\/\/dx.doi.org\/10.1021\/ja00401a050\"><em>J. Am. Chem. Soc<\/em>. 1981, 103, 3213,<\/a> doi: <a href=\"https:\/\/doi.org\/10.1021\/ja00401a050\">10.1021\/ja00401a050<\/a><\/li>\n<li><a href=\"http:\/\/dx.doi.org\/10.1021\/ja00401a051\"><em>J. Am. Chem. Soc.<\/em> 1981, 103, 3215,<\/a> doi: <a href=\"https:\/\/doi.org\/10.1021\/ja00401a051\">10.1021\/ja00401a051<\/a><\/li>\n<li><em>Science<\/em>, 1933, 77, 289, doi: 10.1126\/science.77.1994.289<\/li>\n<\/ol>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u5b59\u82cf\u8d5f \u5364\u539f\u5b50\u548c\u78fa\u9178\u916f\u5728\u4e00\u5b9a\u7684\u6761\u4ef6\u4e0b\u90fd\u662f\u4e0d\u9519\u7684\u79bb\u53bb\u57fa\u56e2\uff0c\u9664\u4e86\u53d6\u4ee3\u53cd\u5e94\uff0c\u4ed6\u4eec\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u6d88\u9664\u53cd\u5e94\u7684\u5e95\u7269\u3002 \u8102\u80aa\u5364\u4ee3\u70c3\u548c\u78fa\u9178\u916f (1) \u78b1\u4f5c\u7528\u4e0b\u7684\u6d88\u9664\u53cd\u5e94 (Zaitsev\u6d88\u9664) \u5bf9\u4e8e\u6d88\u9664\u53cd\u5e94\u6765\u8bf4\uff0c\u65e0\u8bba\u53cd\u5e94\u662f\u901a\u8fc7E1\uff0cE2\u673a\u7406\uff0c\u8fd8\u662fE1cb\u673a\u7406\uff0c\u90fd\u4f1a\u6bd4\u9884\u671f\u7684\u66f4\u96be\u53d1\u751f\uff0c\u5e76\u4e14\u4f1a\u4ea7\u751f\u591a\u79cd\u6d88\u9664\u5f02\u6784\u4f53\uff0c\u5305\u62ec\u533a\u57df\u5f02\u6784\u4f53\u548cZ\/E-\u5f02\u6784\u4f53\u3002\u901a\u5e38\u6765\u8bf4\u53cd\u5e94\u7684\u4ea7\u7269\u662f\u53d6\u4ee3\u8f83\u591a\u7684\u8f83\u7a33\u5b9a\u7684\u53cc\u952e\uff08Zaitsev\u89c4\u5219\uff09\uff0c\u6b64\u5916\u6d88\u9664\u4e5f\u4f1a\u548c\u4eb2\u6838\u53d6\u4ee3\u6709\u7ade\u4e89\u53cd\u5e94\u3002 \u6d88\u9664\u53cd\u5e94\u4e00\u822c\u6709\u4e00\u4e0b\u51e0\u4e2a\u5f71\u54cd\u56e0\u7d20\uff1a \u53cd\u5e94\u5e95\u7269\uff1a a.1o\u548c2o\u5364\u4ee3\u70c3\u548c\u78fa\u9178\u916f\uff1aE2\u6d88\u9664\uff0c\u7acb\u4f53\u7279\u5f02\u6027\u7684\u53cd\u5f0f\u6d88\u9664\u8fc7\u7a0b\uff1b b. 3o\uff0c\u82ef\u7532\u9187\u7c7b\uff1aE1\u6d88\u9664 c. \u03b1-\u5364\u4ee3\u7fb0\u57fa\u5316\u5408\u7269\uff1aE1cb\u6d88\u9664 \u79bb\u53bb\u57fa\u56e2\uff1a\u7f9f\u57fa\u7684\u79bb\u53bb\u6027\u8d28\u8f83\u5dee\uff0c\u901a\u5e38\u5bf9\u4e8eE2\u548cE1cb\u53cd\u5e94\u4f1a\u9700\u8981\u6d3b\u5316\u8f6c\u5316\u6210\u5176\u4ed6\u7684\u57fa\u56e2\uff0c\u9178\u6027\u6761\u4ef6\u4e0b\u53ef\u4ee5\u8fdb\u884cE1\u6d88\u9664\u3002 \u78b1\uff1a \u5927\u4f53\u79ef\u7684\u78b1\u6709\u5229\u4e8e\u6d88\u9664\uff0c\u51cf\u5c11\u53d6\u4ee3\uff1b \u5e38\u7528\u7684\u6709\uff1a \u51e0\u4e2a\u4f8b\u5b50\uff1a \u7898\u4ee3\u70c3\u7684\u6d88\u9664[1]\u8fd9\u4e00\u6b65\u662fCorey\u8bfe\u9898\u7ec4\u7684prostaglandin\u7684\u5168\u5408\u6210\u7684\u4e2d\u7684\u91cd\u8981\u6b65\u9aa4\uff0c\u6d88\u9664\u53ea\u4f1a\u4ea7\u751f\u4e00\u79cd\u5f02\u6784\u4f53\uff0c\u9009\u62e9\u6027\u975e\u5e38\u597d\u3002 \u6eb4\u4ee3\u70c3\u7684\u6d88\u9664[2] \u53cd\u5e94\u4e2d\uff0c\u73af\u6c27\u5316\u7269\u5e76\u6ca1\u6709\u53d1\u751f\u5f00\u73af\u53cd\u5e94\u3002 (2) \u8fd8\u539f\u6d88\u9664\u53cd\u5e94 \u8fd9\u4e2a\u53cd\u5e94\u4e2d\uff0c\u9996\u5148\u662f\u8fc7\u6e21\u91d1\u5c5e\u548c\u5364\u4ee3\u70c3\u53d1\u751f\u6c27\u5316\u52a0\u6210\uff0c\u4e4b\u540e\u53ef\u4ee5\u975e\u5e38\u987a\u5229\u7684\u8fdb\u884c\u03b2-H\u6d88\u9664\u3002\u4f46\u5176\u5b9e\u8fd9\u6837\u7684\u03b2-H\u6d88\u9664\u5728\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u4e2d\u662f\u4e0d\u5e0c\u671b\u53d1\u751f\u7684\u526f\u53cd\u5e94\uff0c\u4f46\u662f\u5374\u53ef\u4ee5\u6e29\u548c\u5730\u7528\u4f5c\u6d88\u9664\u5364\u7d20\u5f97\u5230\u53cc\u952e\u3002 \u8fd9\u4e2a\u53cd\u5e94\u7684\u5e94\u7528\u4e0d\u662f\u5f88\u591a\uff0c\u8fd9\u91cc\u4e00\u4e2a\u4f8b\u5b50\uff1a[3] \u51e0\u79cd\u8131\u6c34\u53cd\u5e94 (1) Grieco\u6d88\u9664\u53cd\u5e94 Grieco\u6d88\u9664\u53cd\u5e94\u4e2d\u4f7f\u7528\u5230\u4e86\u7852\u8bd5\u5242\u4f5c\u4e3a\u6c27\u5316\u5242\uff0c\u53cd\u5e94\u4e2d\u53d1\u751f\u7684\u662f\u70ed\u529b\u5b66\u6d88\u9664\uff0c\u53cd\u5e94\u5bf9\u4e8e1o\u9187\u6548\u679c\u975e\u5e38\u597d\u3002\u53cd\u5e94\u4e2d\u8bd5\u5242\u6d3b\u5316\u7684\u8fc7\u7a0b\u548cMitsunobu\u53cd\u5e94\u7c7b\u4f3c\uff0c\u6b64\u5916\u7b2c\u4e8c\u6b65\u7684\u6c27\u5316\u8fc7\u7a0b\u4e2d\u6c27\u5316\u5242\u7684\u9009\u62e9\u8303\u56f4\u5f88\u5e7f\uff0c\u5e38\u89c1\u7684\u6709H2O2\uff0cm-CPBA\uff0c\u7b49\u3002 \u53cd\u5e94\u673a\u7406\uff1a \u4f8b\u5982\uff1a [4] \u7531\u4e8e\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u4f1a\u4ea7\u751f\u6c30\u8d1f\u79bb\u5b50\uff0c\u56e0\u6b64\u6709\u4e00\u5b9a\u7684\u51e0\u7387\u4f1a\u4ea7\u751f\u6c30\u4ee3\u7684\u526f\u4ea7\u7269\u3002 \u00a0 b. [5] \u00a0 c. [6, 7] (2) Bogert-Cook Synthesis[8] \u8fd9\u4e2a\u53cd\u5e94\u662f\u7531Bogert\u8bfe\u9898\u7ec4\u548cCook\u8bfe\u9898\u7ec4\u51e0\u4e4e\u540c\u65f6\u57281993\u5e74\u62a5\u9053\u7684\uff0c\u53cd\u5e94\u8fc7\u7a0b\u662fGrignard\u8bd5\u5242\u548c\u916e\u53cd\u5e94\u751f\u6210\u5f97\u5230\u4e86\u4e00\u4e2a\u5e76\u4e09\u73af\u5316\u5408\u7269\u3002\u8fd9\u662f\u5728\u8d28\u5b50\u9178\u6761\u4ef6\u4e0b\u7f9f\u57fa\u8131\u6c34\u7ecf\u5386\u78b3\u6b63\u79bb\u5b50\u7684\u4e00\u4e2a\u5f88\u597d\u7684\u4f8b\u5b50\uff0c\u5f53\u53cd\u5e94\u4e2d\u95f4\u4f53\u548c\u4e00\u4e2a\u6e29\u548c\u7684\u8131\u6c34\u8bd5\u5242\u63a5\u89e6\u65f6\uff0c\u53cd\u5e94\u7684\u540e\u4e00\u9636\u6bb5\u8131\u6c34\u5f97\u5230\u53cc\u952e\uff0c\u5e76\u4e14\u6210\u73af\uff0c\u4f46\u662f\u6210\u73af\u8fc7\u7a0b\u4e2d\u5177\u4f53\u7684\u4f4d\u7f6e\u662f\u548c\u53cd\u5e94\u5e95\u7269\u6027\u8d28\u6709\u5173\u3002 REFERENCES J. Am. Chem. Soc., 1973, 95, 20, 6832-6833, doi: 10.1021\/ja00801a053 J. Am. Chem. Soc., 2005, 127, 31, 11159-11175, doi: 10.1021\/ja0529337 J. Am. Chem. Soc., 2012, 134, 34, 14232-14237, doi: 10.1021\/ja306323x J. Am. Chem. Soc., 2010, 13, 25, 1488-1489, 10.1021\/ja9104478 Tetrahedron Lett. 2004, 45, 3783. doi :1016\/j.tetlet.2004.03.085 J. Am. Chem. Soc. 1981, 103, 3213, doi: 10.1021\/ja00401a050 J. Am. Chem. Soc. 1981, 103, 3215, doi: 10.1021\/ja00401a051 [&hellip;]","protected":false},"author":26,"featured_media":28695,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[315],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/833036171d2a3f394220c043f5db779a-1.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-7nT","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/28389"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=28389"}],"version-history":[{"count":3,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/28389\/revisions"}],"predecessor-version":[{"id":41869,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/28389\/revisions\/41869"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/28695"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=28389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=28389"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=28389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}