{"id":28563,"date":"2019-08-22T08:00:34","date_gmt":"2019-08-22T00:00:34","guid":{"rendered":"\/\/www.gsbet888.com\/?p=28563"},"modified":"2019-08-19T22:58:26","modified_gmt":"2019-08-19T14:58:26","slug":"%e6%9e%97-%e9%9b%84%e4%ba%8c%e9%83%8e%e6%95%99%e6%8e%88%e7%9a%84pot-economy-%e5%8c%96%e5%ad%a6","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2019\/08\/%e6%9e%97-%e9%9b%84%e4%ba%8c%e9%83%8e%e6%95%99%e6%8e%88%e7%9a%84pot-economy-%e5%8c%96%e5%ad%a6.html","title":{"rendered":"\u6797 \u96c4\u4e8c\u90ce\u6559\u6388\u7684pot-economy \u5316\u5b66"},"content":{"rendered":"<p>\u6b64\u6587\u7ffb\u8bd1\u4e8e\u5316\u5b66\u7a7a\u95f4\u65e5\u672c\u7248\uff0c\u4f5c\u8005\u4e3a<a href=\"\/\/www.gsbet888.com\/chemists\/2018\/01\/%e6%9e%97-%e9%9b%84%e4%ba%8c%e9%83%8e-yujiro-hayashi.html\">\u6797 \u96c4\u4e8c\u90ce<\/a>\u6559\u6388\u7684\u535a\u58eb\u751f\uff0c\u672c\u6587\u9996\u53d1\u4e8e\u300a\u73b0\u4ee3\u5316\u5b66\u300b\u8bbf\u8c08\u7279\u8f91\u3002<\/p>\n<p>\u672c\u6587\u7ffb\u8bd1\uff1aalberto-caeiro<\/p>\n<h4><strong>\u7ecf\u6d4e\u7684\u4e00\u9505\u5408\u6210\u6cd5<\/strong><\/h4>\n<p>\u2014\u2014pot-economy\u6982\u5ff5\u662f\u7531\u4e1c\u5317\u5927\u5b66\u7684\u6797\u6559\u6388\u63d0\u51fa\u3002\u9996\u5148\uff0cPot-economy\u662f\u600e\u6837\u7684\u6982\u5ff5\u5462\uff1f\u518d\u8005\uff0cpot-economy\u63d0\u51fa\u7684\u5951\u673a\u662f\u4ec0\u4e48\u5462\uff1f<\/p>\n<p><strong>\u6797\uff1a<\/strong>pot-economy\u662f\u6307\u5c06\u8fde\u7eed\u7684\u53cd\u5e94\u653e\u5728\u4e00\u4e2a\u53cd\u5e94\u5bb9\u5668(One Pot)\u4e2d\u8fdb\u884c\u4ee5\u5f97\u5230\u76ee\u6807\u5316\u5408\u7269\u7684\u8fc7\u7a0b\uff0c\u5728\u53cd\u5e94\u4e2d\u4e0d\u9700\u8981\u5206\u79bb\u63d0\u7eaf\uff0c\u4ece\u800c\u4ee5\u66f4\u65e9\u65f6\u95f4\u548c\u66f4\u597d\u7684\u6536\u7387\u5f97\u5230\u76ee\u6807\u5316\u5408\u7269\u3002\u6211\u4eec\u662f\u5728\u6297\u6d41\u611f\u836f\u8fbe\u83f2(Tamiflu\uff0c\u5546\u54c1\u540d\u4e3a\u78f7\u9178\u5965\u53f8\u4ed6\u97e6\u80f6\u56ca)\u7684\u5168\u5408\u6210\u4e2d\u60f3\u5230\u4e86\u8fd9\u4e2a\u6982\u5ff5\u3002<\/p>\n<p>2005\u5e74\u7684\u65f6\u5019\uff0c\u6709\u673a\u5316\u5b66\u5bb6<a href=\"\/\/www.gsbet888.com\/chemnews\/2017\/10\/gilbert-stork%e6%9c%80%e5%90%8e%e7%9a%84%ef%bc%9f%e8%ae%ba%e6%96%87.html\">Gilbert Stork<\/a>\u5728\u65e5\u672c\u6765\u8bbf\u671f\u95f4\uff0c\u4e0e\u4e1c\u4eac\u5468\u8fb9\u7684\u5e74\u8f7b\u7814\u7a76\u8005\u4eec\u4e00\u9053\u53ec\u5f00\u4e86\u4e00\u6b21\u7814\u8ba8\u4f1a\u3002\u90a3\u4e2a\u65f6\u5019\u6211\u8fd8\u662f\u4e1c\u4eac\u7406\u79d1\u5927\u5b66\u4efb\u804c\uff0c\u5f53\u65f6\u7684\u52a9\u624b\u5e84\u53f8\u6ee1\u6559\u6388(\u73b0\u6a2a\u6ee8\u836f\u79d1\u5927\u5b66)\u53d1\u8868\u4e86Epoxyquinol\u7684\u5408\u6210\u7814\u7a76\u3002<\/p>\n<p>Stork\u6559\u6388\u5f53\u65f6\u8bc4\u4ef7\u5230\uff1a\u53cd\u5e94\u7684\u4e2d\u95f4\u4f53\u53ef\u4ee5\u7528\u4e8eTamiflu\u7684\u5408\u6210\u554a\u3002\u800c\u6211\u4eec\u5f53\u65f6\u5bf9Tamiflu\u6ca1\u6709\u4efb\u4f55\u4e86\u89e3\uff0c\u4f46\u4e2d\u95f4\u4f53\u5374\u597d\u50cf\u80fd\u7528\u4e8e\u5b83\u7684\u5408\u6210\u3002\u53ea\u662f\u5168\u5408\u6210\u7684\u603b\u8def\u7ebf\u4f1a\u592a\u957f\u4e86\uff0cTamiflu\u662f\u4ee5\u73af\u5df1\u70ef\u4e3a\u4e3b\u8981\u9aa8\u67b6\uff0c\u73af\u4e0a\u67093\u4e2a\u8fde\u7eed\u7684\u624b\u6027\u78b3\uff0c\u56e0\u6b64\u4f5c\u4e3a\u5c0f\u5206\u5b50\u7684\u5408\u6210\u7edd\u975e\u6613\u4e8b\u3002\u5982\u4f55\u4ee5\u8f83\u77ed\u7684\u7ebf\u6027\u603b\u6b65\u6570\u7684\u5b8c\u6210Tamiflu\u7684\u5168\u5408\u6210\uff0c\u4e3a\u6b64\u6211\u4eec\u6bcf\u5929\u90fd\u7ede\u5c3d\u8111\u6c41\u7684\u601d\u8003\u7740\u5b83\u7684\u9006\u5408\u6210\u5206\u6790\u3002\u540e\u9762\uff0c\u5173\u4e8eTamiflu\u7684\u5408\u6210\u5de5\u4f5c\u662f\u7531\u5f53\u65f6\u7684\u52a9\u6559\u77f3\u5ddd\u52c7\u4eba(\u73b0\u718a\u672c\u5927\u5b66)\u63a8\u8fdb\u7684\u3002<\/p>\n<p>\u5f53\u65f6\u6211\u4eec\u4e5f\u6709\u8fdb\u884c\u5173\u4e8e\u6709\u673a\u50ac\u5316\u7684\u5de5\u4f5c\u3002\u4e8e\u662f\u57282009\u5e74\u7684\u65f6\u5019\uff0c\u5229\u7528\u4e0a\u6211\u4eec\u81ea\u5df1\u5f00\u53d1\u7684\u6709\u673a\u50ac\u5316\u5242\u548c\u50ac\u5316\u53cd\u5e94\uff0c\u901a\u8fc73\u9505\u5b8c\u6210\u4e86Tamiflu\u7684\u5168\u5408\u6210\u5de5\u4f5c\u3002(<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.200804883\"><em>Angew. Chem. Int. Ed<\/em>. <strong>2009<\/strong>, <em>48<\/em>, 1304<\/a>.) \u6211\u4eec\u5728\u5de5\u4f5c\u5b8c\u6210\u7684\u8fc7\u7a0b\u4e2d\u9047\u4e0a\u4e86\u8bb8\u591a\u7684\u56f0\u96be\u3002<\/p>\n<p>\u6210\u529f\u7684\u5173\u952e\u5728\u4e8e\u6700\u5927\u9650\u5ea6\u7684\u5229\u7528\u4e0a\u4e86\u5f53\u65f6\u6b63\u84ec\u52c3\u53d1\u5c55\u7684\u6709\u673a\u50ac\u5316\u5242\u7684\u4f18\u70b9\uff0c\u7136\u800c\u6211\u4eec\u8fd8\u662f\u9047\u5230\u4e86\u4e00\u4e9b\u95ee\u9898\u3002\u6bd4\u5982\u9664\u4e86\u76ee\u6807\u4ea7\u7269\uff0c\u8fd8\u751f\u6210\u4e86\u4e24\u4e2a\u5404\u536030%\u7684\u526f\u4ea7\u7269\u3002\u4e00\u822c\u6765\u8bf4\uff0c\u9047\u4e0a\u8fd9\u79cd\u60c5\u51b5\uff0c\u4e2d\u9014\u653e\u5f03\u7684\u60c5\u51b5\u4e5f\u662f\u6709\u7684\uff0c\u4f46\u662f\u77f3\u5ddd\u8001\u5e08\u8ba4\u771f\u7684\u5206\u79bb\u4e86\u6bcf\u4e2a\u526f\u4ea7\u7269\uff0c\u5e76\u4ed4\u7ec6\u7684\u89e3\u51fa\u4e86\u6bcf\u4e2a\u526f\u4ea7\u7269\u7684\u7ed3\u6784\u3002\u539f\u6765\uff0c\u53cd\u5e94\u7684\u526f\u4ea7\u7269\u662f\u539f\u6599\u5728\u53d1\u751fHWE\u53cd\u5e94(Horner-Wadsworth-Emmons Reaction)\u65f6\u672a\u5b8c\u5168\u53cd\u5e94\u7684\u4e2d\u95f4\u4f53\u548c\u4ea7\u7269\u7ee7\u7eed\u53d1\u751f\u53cd\u5e94\u7684\u975e\u76ee\u6807\u4ea7\u7269\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u7b80\u5355\u7684\u5316\u5b66\u8f6c\u5316\u5c31\u53ef\u5c06\u526f\u4ea7\u7269\u8f6c\u5316\u4e3a\u76ee\u6807\u4ea7\u7269\u3002<\/p>\n<p>\u5728\u526f\u4ea7\u7269\u8f6c\u5316\u4e3a\u4ea7\u7269\u6761\u4ef6\u63a2\u7d22\u4e2d\uff0c\u6211\u4eec\u4e86\u89e3\u5230\uff0c\u53ef\u4ee5\u5c06\u5728\u524d\u4e00\u6b65\u53cd\u5e94\u4e2d\u5df2\u7ecf\u4f7f\u7528\u7684\u78b3\u9178\u94ef\u4f5c\u4e3a\u78b1\uff0c\u4ee5\u4e59\u9187\u4f5c\u4e3a\u6eb6\u5242\uff0c\u76ee\u6807\u5316\u5408\u7269\u5c31\u53ef\u4ee5\u9ad8\u6536\u7387\u7684\u8f6c\u5316\u5f97\u5230\u3002\u56e0\u6b64\uff0c\u53ea\u9700\u8981\u5728\u6b63\u5e38\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u8ffd\u52a0\u4e59\u9187\u5373\u53ef\u53d1\u751f\u65b0\u7684\u53cd\u5e94\uff0c\u53cd\u5e94\u4f53\u7cfb\u5c06\u5b8c\u5168\u8f6c\u5316\u4e3a\u76ee\u6807\u5316\u5408\u7269\uff0c\u4ece\u800c\u5927\u5927\u7b80\u5316\u53cd\u5e94\u64cd\u4f5c\uff0c\u4e0d\u518d\u9700\u8981\u52a0\u5165\u6dec\u706d\u5242\u7ec8\u6b62\u53cd\u5e94\uff0c\u8403\u53d6\uff0c\u5e72\u71e5\uff0c\u65cb\u8f6c\u84b8\u53d1\u9664\u53bb\u6eb6\u5242\u548c\u67f1\u5c42\u6790\u5206\u79bb\u8fd9\u4e00\u7cfb\u5217\u7e41\u7410\u7684\u540e\u5904\u7406\u64cd\u4f5c\u4e86\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u8fd9\u91cc\u5c31\u6ca1\u6709\u5206\u79bb\u63d0\u7eaf\u7684\u5fc5\u8981\u4e86\uff0c\u51cf\u5c11\u4e86\u53cd\u5e94\u7684\u5de5\u7a0b\u6570\u4ece\u800c\u589e\u52a0\u53cd\u5e94\u6536\u7387\u3002\u5b9e\u9645\u4e0a\u6709\u673a\u5316\u5b66\u53cd\u5e94\u4e2d\u82b1\u8d39\u65f6\u95f4\u6700\u591a\u7684\u5c31\u662f\u540e\u5904\u7406\u8fc7\u7a0b\u4e86\uff0c\u51e0\u5206\u949f\u5c31\u53ef\u5b8c\u5168\u8f6c\u5316\u7684\u53cd\u5e94\u5374\u9700\u8981\u51e0\u4e2a\u5c0f\u65f6\u6765\u540e\u5904\u7406\u5f97\u5230\u4ea7\u7269\u7684\u4f8b\u5b50\u4e5f\u4e0d\u662f\u4ec0\u4e48\u7a00\u7f55\u4e8b\u3002<\/p>\n<p>\u4ee5\u5f80\u7684\u5316\u5b66\u5e38\u8bc6\u544a\u8bc9\u6211\u4eec\uff0c\u4e00\u4e2a\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5e94\u8be5\u7ec8\u6b62\u53cd\u5e94\u5e76\u8fdb\u884c\u7eaf\u5316\uff0c\u7136\u540e\u8fdb\u884c\u4e0b\u4e00\u6b65\u53cd\u5e94\u3002\u4e8e\u6b64\u76f8\u5bf9\u5e94\uff0c\u5982\u679c\u5728\u53cd\u5e94\u672c\u8eab\u4e0a\u4e0b\u529f\u592b\u7684\u8bdd\uff0c\u80fd\u5426\u540c\u4e00\u53cd\u5e94\u5bb9\u5668\u5185\u8fdb\u884c\u591a\u4e2a\u8fde\u7eed\u7684\u53cd\u5e94\u5462\uff1f\u5982\u679c\u80fd\u591f\u7684\u8bdd\uff0c\u4f1a\u975e\u5e38\u6709\u8da3\u7684\u5427\uff0c\u6211\u4eec\u7075\u673a\u4e00\u52a8\uff0c\u7a81\u7136\u6709\u4e86\u8fd9\u6837\u4e00\u4e2a\u60f3\u6cd5\u3002\u8d2f\u5f7b\u8fd9\u4e2a\u60f3\u6cd5\u7684\u8bdd\uff0c\u6211\u4eec\u80fd\u505a\u6210\u4ec0\u4e48\u6837\u5b50\u5462\uff1f\u540e\u6765\u6211\u4eec\u4fbf\u5c06\u6b64\u76ee\u7684\u4f5c\u4e3a\u5408\u6210\u5de5\u4f5c\u4e2d\u7684\u4e00\u4e2a\u6311\u6218\u3002\u6700\u7ec8\uff0c\u6211\u4eec\u5c45\u7136\u53ea\u7528\u4e863\u9505\u5c31\u5b8c\u6210\u4e86Tamiflu\u7684\u5168\u5408\u6210\u3002<\/p>\n<p>\u9700\u8981\u5f3a\u8c03\u7684\u662f\uff0c\u7528\u7ecf\u91cf\u5c11\u7684\u5de5\u7a0b\u6570\u5408\u6210\u76ee\u6807\u5206\u5b50\uff0c\u5e76\u4e0d\u662f\u8be5\u5de5\u4f5c\u4e00\u5f00\u59cb\u7684\u76ee\u6807\uff0c\u6211\u4eec\u662f\u5728\u5408\u6210\u4e2d\u8ba4\u8bc6\u5230\u4e86\u6b64\u8fc7\u7a0b\u7684\u91cd\u8981\u6027\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-28564 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/ee6df7033a974fd2d6b73e2297a56fc1-5.png\" alt=\"\" width=\"753\" height=\"490\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/ee6df7033a974fd2d6b73e2297a56fc1-5.png 1044w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/ee6df7033a974fd2d6b73e2297a56fc1-5-300x195.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/ee6df7033a974fd2d6b73e2297a56fc1-5-768x499.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/ee6df7033a974fd2d6b73e2297a56fc1-5-680x442.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/ee6df7033a974fd2d6b73e2297a56fc1-5-260x170.png 260w\" sizes=\"(max-width: 753px) 100vw, 753px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>Tamiflu\u5408\u6210\u4e2d\u9047\u5230\u7684\u56f0\u96be<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-28565 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/8a68c7643065119a2ccf860543dbbda8-2.png\" alt=\"\" width=\"733\" height=\"488\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/8a68c7643065119a2ccf860543dbbda8-2.png 1035w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/8a68c7643065119a2ccf860543dbbda8-2-300x200.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/8a68c7643065119a2ccf860543dbbda8-2-768x511.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/08\/8a68c7643065119a2ccf860543dbbda8-2-680x453.png 680w\" sizes=\"(max-width: 733px) 100vw, 733px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u5168\u5408\u6210\u8def\u7ebf\u56fe<\/strong><\/p>\n<p>\u2015\u2015\u8be5\u65b9\u6cd5\u5408\u6210Tamiflu\u7684\u6536\u7387\u662f\u76ee\u524d\u5df2\u62a5\u9053\u6587\u732e\u4e2d\u6700\u9ad8\u7684\uff0c\u80fd\u591f\u8fbe\u523057%\u3002<\/p>\n<p>\u6797\uff1aTamiflu\u7684\u5168\u5408\u6210\u5de5\u4f5c\u5728\u8bb8\u591a\u8bfe\u9898\u7ec4\u90fd\u6709\u8fdb\u884c\uff0c\u800c\u5df2\u7ecf\u62a5\u9053\u7684\u5408\u6210\u8def\u7ebf\u5c31\u8d85\u8fc760\u6761\uff0c\u8fd9\u79cd\u70ed\u5ea6\u662f\u5176\u4ed6\u5316\u5408\u7269\u4e0d\u80fd\u6bd4\u62df\u7684\u3002\u5728\u6211\u4eec\u7684\u5de5\u4f5c\u53d1\u8868\u524d\uff0c<a href=\"\/\/www.gsbet888.com\/chemists\/2014\/06\/%e5%b7%b4%e9%87%8c%c2%b7%e7%89%b9%e7%bd%97%e6%96%af%e7%89%b9-barry-m-trost.html\">Barry M. Trost<\/a>\u6559\u6388\u4ee530%\u7684\u603b\u6536\u7387\uff0c\u975e\u5e38\u6f02\u4eae\u7684\u5b8c\u6210\u4e86\u5408\u6210\u5de5\u4f5c\u3002\u5728\u5f53\u65f6\uff0c\u53cd\u5e94\u7684\u603b\u6536\u7387\u662f\u4f5c\u4e3a\u5408\u6210\u5de5\u4f5c\u4e2d\u7684\u4e00\u4e2a\u8bc4\u5224\u6307\u6807\u3002<\/p>\n<p>\u5b9e\u9645\u4e0a\u6211\u4eec\u6700\u521d\u5411<em>Angewandte Chemie<\/em>\u6295\u7a3f\u7684\u65f6\u5019\uff0c\u603b\u6536\u7387\u662f\u572830%\uff0c\u548cTrost\u6559\u6388\u7684\u5de5\u4f5c\u90fd\u662f\u5f53\u65f6\u7684\u6700\u9ad8\u6536\u7387\u3002\u4f46\u5728\u67d0\u4e2a\u62a5\u544a\u4e0a\u53d1\u8868\u6b64\u5de5\u4f5c\u65f6\uff0c<a href=\"\/\/www.gsbet888.com\/interview\/2014\/06\/%e7%ac%ac%e4%b8%80%e5%9b%9e%e3%80%80%e7%a6%8f%e5%b1%b1%e9%80%8f%e6%95%99%e6%8e%88%e3%83%bc%e8%87%aa%e7%94%b1%e8%87%aa%e5%9c%a8%e5%90%88%e6%88%90%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9.html\">\u798f\u5c71\u900f<\/a>\u5148\u751f\u8bc4\u4ef7\u5230\u6b64\u53cd\u5e94\u7684\u975e\u5bf9\u6620\u9009\u62e9\u6027\u8f83\u4f4e\u3002\u8fd9\u4e5f\u662f\u6211\u4eec\u81ea\u8eab\u96be\u4ee5\u63a5\u53d7\u7684\u4e00\u4e2a\u70b9\u3002\u7136\u800c\u5f53\u65f6\u8bba\u6587\u5df2\u7ecf\u88ab\u63a5\u53d7\u4e86\uff0c\u5e76\u4e14\u88ab\u9009\u4e3aVIP(Very Important Paper)\u6587\u7ae0\uff0c\u8ddd\u79bb\u4fee\u6539\u65e5\u671f\u8fd8\u6709\u51e0\u5929\u5c31\u9700\u8981\u63d0\u4ea4\u6700\u7ec8\u7684\u6587\u7ae0\u4e86\u3002\u4f46\u6211\u4eec\u5bf9\u8fd9\u6837\u7684\u7ed3\u679c\u4e5f\u975e\u5e38\u4e0d\u7518\u5fc3\uff0c\u5728\u6700\u540e\u671f\u9650\u524d\u8fd8\u4e00\u76f4\u5728\u7ee7\u7eed\u4f18\u5316\u5b9e\u9a8c\u3002<\/p>\n<p>\u6b63\u662f\u5728\u8fd9\u6837\u7684\u52aa\u529b\u4e0b\uff0c\u8be5\u95ee\u9898\u6700\u7ec8\u5f97\u5230\u89e3\u51b3\uff0c\u603b\u6536\u7387\u4e5f\u63d0\u9ad8\u5230\u4e86\u63a5\u8fd160%\uff0c\u5c06\u6700\u9ad8\u6536\u7387\u4e5f\u5927\u5927\u63d0\u9ad8\u4e86\u3002\u8fd9\u771f\u662f\u4e00\u79cd\u9047\u5230\u95ee\u9898\u65f6\u7684\u8f83\u771f\u52b2\u554a\u3002\u672c\u676530%\u6536\u7387\u5c31\u8ba9\u4eba\u6ee1\u8db3\u7684\u7814\u7a76\uff0c\u56e0\u4e3a\u798f\u5c71\u5148\u751f\u7684\u4e00\u53e5\u5efa\u8bae\uff0c\u53d8\u6210\u4e86\u6709\u8f83\u5927\u7a81\u7834\u7684\u5de5\u4f5c\u3002\u540e\u6765\u8bba\u6587\u4e5f\u5728\u5370\u5237\u524d\u64a4\u4e0b\uff0c\u5927\u5e45\u4fee\u6539\u540e\u91cd\u65b0\u6295\u7a3f\u3002<\/p>\n<p>\u53ef\u60dc\u518d\u6b21\u6295\u7a3f\u65f6\u5e76\u6ca1\u6709\u9009\u4e0aVIP\u6587\u7ae0\u3002\u5b9e\u9645\u4e0a\u8fd9\u7bc7\u6587\u7ae0\u540e\u9762\u4e5f\u6709\u6545\u4e8b\uff0c\u91cd\u65b0\u5199\u7684\u6587\u7ae0\u6700\u521d\u662f\u51c6\u5907\u6295Nature\u7684\uff0c\u53ea\u53ef\u60dc\u88ab\u62d2\u4e86\u3002\u4f46\u662f\uff0c\u540e\u9762\u5728<em>Angewandte Chemie<\/em>\u53d1\u8868\u540e\uff0c Nature\u6742\u5fd7highlight\u680f\u4e5f\u4ecb\u7ecd\u4e86\u8fd9\u7bc7\u5de5\u4f5c\uff0c\u800c\u8fd9\u4efd\u5408\u6210\u5de5\u4f5c\u4e5f\u88ab\u5f88\u591a\u4eba\u5f15\u7528\uff0c\u540c\u884c\u4eec\u7684\u8bc4\u4ef7\u4e5f\u5f88\u9ad8\u3002\u8fd9\u7bc7\u5de5\u4f5c\u80cc\u540e\u7684\u6545\u4e8b\u540e\u9762\u5e94\u8be5\u4f1a\u88ab\u5927\u5bb6\u6240\u4e86\u89e3\u5427\u3002<\/p>\n<p>\u5728\u8fd9\u4e2a\u5de5\u4f5c\u5f00\u59cb\u524d\uff0c\u6211\u4eec\u5e76\u6ca1\u6709\u4ee5\u7528\u5c3d\u91cf\u5c11\u7684\u6b65\u6570\u5b8c\u6210\u5408\u6210\u4e3a\u76ee\u6807\uff0c\u4f46\u662f\u8fdb\u884c\u8fd9\u4e2a\u5de5\u4f5c\u8fc7\u7a0b\u4e2d\u7684\u7ecf\u9a8c\u5374\u662f\u63d0\u51fapot-economy\u7684\u5951\u673a\u3002<\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<ul style=\"list-style-type: circle;\">\n<li>First generation of the synthesis of (-)-Oseltamivir: Ishikawa, H.; Suzuki, T.; Hayashi, Y. <em>Angew. Chem. Int. Ed.<\/em> <strong>2009<\/strong>, <em>48<\/em>, 1304.<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.200804883\">\u00a0DOI: 10.1002\/anie.200804883<\/a>.<\/li>\n<li>Second generation: Ishikawa, H.; Suzuki,T.; Orita,H.; Uchimaru, T.; Hayashi, Y. <em>Chem. Eur. J.<\/em> <strong>2010<\/strong>, <em>16<\/em>, 12616. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/chem.201001108\">DOI: 10.1002\/chem.201001108<\/a>.<\/li>\n<li>Third generation: Mukaiyama, T.; Ishikawa, H.; Koshino, H.; Hayashi, Y. <em>Chem. Eur. J.<\/em> <strong>2013<\/strong>, <em>19<\/em>, 17789. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/chem.201302371\">DOI: 10.1002\/chem.201302371<\/a><\/li>\n<\/ul>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"\u6b64\u6587\u7ffb\u8bd1\u4e8e\u5316\u5b66\u7a7a\u95f4\u65e5\u672c\u7248\uff0c\u4f5c\u8005\u4e3a\u6797 \u96c4\u4e8c\u90ce\u6559\u6388\u7684\u535a\u58eb\u751f\uff0c\u672c\u6587\u9996\u53d1\u4e8e\u300a\u73b0\u4ee3\u5316\u5b66\u300b\u8bbf\u8c08\u7279\u8f91\u3002 \u672c\u6587\u7ffb\u8bd1\uff1aalberto-caeiro \u7ecf\u6d4e\u7684\u4e00\u9505\u5408\u6210\u6cd5 \u2014\u2014pot-economy\u6982\u5ff5\u662f\u7531\u4e1c\u5317\u5927\u5b66\u7684\u6797\u6559\u6388\u63d0\u51fa\u3002\u9996\u5148\uff0cPot-economy\u662f\u600e\u6837\u7684\u6982\u5ff5\u5462\uff1f\u518d\u8005\uff0cpot-economy\u63d0\u51fa\u7684\u5951\u673a\u662f\u4ec0\u4e48\u5462\uff1f \u6797\uff1apot-economy\u662f\u6307\u5c06\u8fde\u7eed\u7684\u53cd\u5e94\u653e\u5728\u4e00\u4e2a\u53cd\u5e94\u5bb9\u5668(One Pot)\u4e2d\u8fdb\u884c\u4ee5\u5f97\u5230\u76ee\u6807\u5316\u5408\u7269\u7684\u8fc7\u7a0b\uff0c\u5728\u53cd\u5e94\u4e2d\u4e0d\u9700\u8981\u5206\u79bb\u63d0\u7eaf\uff0c\u4ece\u800c\u4ee5\u66f4\u65e9\u65f6\u95f4\u548c\u66f4\u597d\u7684\u6536\u7387\u5f97\u5230\u76ee\u6807\u5316\u5408\u7269\u3002\u6211\u4eec\u662f\u5728\u6297\u6d41\u611f\u836f\u8fbe\u83f2(Tamiflu\uff0c\u5546\u54c1\u540d\u4e3a\u78f7\u9178\u5965\u53f8\u4ed6\u97e6\u80f6\u56ca)\u7684\u5168\u5408\u6210\u4e2d\u60f3\u5230\u4e86\u8fd9\u4e2a\u6982\u5ff5\u3002 2005\u5e74\u7684\u65f6\u5019\uff0c\u6709\u673a\u5316\u5b66\u5bb6Gilbert Stork\u5728\u65e5\u672c\u6765\u8bbf\u671f\u95f4\uff0c\u4e0e\u4e1c\u4eac\u5468\u8fb9\u7684\u5e74\u8f7b\u7814\u7a76\u8005\u4eec\u4e00\u9053\u53ec\u5f00\u4e86\u4e00\u6b21\u7814\u8ba8\u4f1a\u3002\u90a3\u4e2a\u65f6\u5019\u6211\u8fd8\u662f\u4e1c\u4eac\u7406\u79d1\u5927\u5b66\u4efb\u804c\uff0c\u5f53\u65f6\u7684\u52a9\u624b\u5e84\u53f8\u6ee1\u6559\u6388(\u73b0\u6a2a\u6ee8\u836f\u79d1\u5927\u5b66)\u53d1\u8868\u4e86Epoxyquinol\u7684\u5408\u6210\u7814\u7a76\u3002 Stork\u6559\u6388\u5f53\u65f6\u8bc4\u4ef7\u5230\uff1a\u53cd\u5e94\u7684\u4e2d\u95f4\u4f53\u53ef\u4ee5\u7528\u4e8eTamiflu\u7684\u5408\u6210\u554a\u3002\u800c\u6211\u4eec\u5f53\u65f6\u5bf9Tamiflu\u6ca1\u6709\u4efb\u4f55\u4e86\u89e3\uff0c\u4f46\u4e2d\u95f4\u4f53\u5374\u597d\u50cf\u80fd\u7528\u4e8e\u5b83\u7684\u5408\u6210\u3002\u53ea\u662f\u5168\u5408\u6210\u7684\u603b\u8def\u7ebf\u4f1a\u592a\u957f\u4e86\uff0cTamiflu\u662f\u4ee5\u73af\u5df1\u70ef\u4e3a\u4e3b\u8981\u9aa8\u67b6\uff0c\u73af\u4e0a\u67093\u4e2a\u8fde\u7eed\u7684\u624b\u6027\u78b3\uff0c\u56e0\u6b64\u4f5c\u4e3a\u5c0f\u5206\u5b50\u7684\u5408\u6210\u7edd\u975e\u6613\u4e8b\u3002\u5982\u4f55\u4ee5\u8f83\u77ed\u7684\u7ebf\u6027\u603b\u6b65\u6570\u7684\u5b8c\u6210Tamiflu\u7684\u5168\u5408\u6210\uff0c\u4e3a\u6b64\u6211\u4eec\u6bcf\u5929\u90fd\u7ede\u5c3d\u8111\u6c41\u7684\u601d\u8003\u7740\u5b83\u7684\u9006\u5408\u6210\u5206\u6790\u3002\u540e\u9762\uff0c\u5173\u4e8eTamiflu\u7684\u5408\u6210\u5de5\u4f5c\u662f\u7531\u5f53\u65f6\u7684\u52a9\u6559\u77f3\u5ddd\u52c7\u4eba(\u73b0\u718a\u672c\u5927\u5b66)\u63a8\u8fdb\u7684\u3002 \u5f53\u65f6\u6211\u4eec\u4e5f\u6709\u8fdb\u884c\u5173\u4e8e\u6709\u673a\u50ac\u5316\u7684\u5de5\u4f5c\u3002\u4e8e\u662f\u57282009\u5e74\u7684\u65f6\u5019\uff0c\u5229\u7528\u4e0a\u6211\u4eec\u81ea\u5df1\u5f00\u53d1\u7684\u6709\u673a\u50ac\u5316\u5242\u548c\u50ac\u5316\u53cd\u5e94\uff0c\u901a\u8fc73\u9505\u5b8c\u6210\u4e86Tamiflu\u7684\u5168\u5408\u6210\u5de5\u4f5c\u3002(Angew. Chem. Int. Ed. 2009, 48, 1304.) \u6211\u4eec\u5728\u5de5\u4f5c\u5b8c\u6210\u7684\u8fc7\u7a0b\u4e2d\u9047\u4e0a\u4e86\u8bb8\u591a\u7684\u56f0\u96be\u3002 \u6210\u529f\u7684\u5173\u952e\u5728\u4e8e\u6700\u5927\u9650\u5ea6\u7684\u5229\u7528\u4e0a\u4e86\u5f53\u65f6\u6b63\u84ec\u52c3\u53d1\u5c55\u7684\u6709\u673a\u50ac\u5316\u5242\u7684\u4f18\u70b9\uff0c\u7136\u800c\u6211\u4eec\u8fd8\u662f\u9047\u5230\u4e86\u4e00\u4e9b\u95ee\u9898\u3002\u6bd4\u5982\u9664\u4e86\u76ee\u6807\u4ea7\u7269\uff0c\u8fd8\u751f\u6210\u4e86\u4e24\u4e2a\u5404\u536030%\u7684\u526f\u4ea7\u7269\u3002\u4e00\u822c\u6765\u8bf4\uff0c\u9047\u4e0a\u8fd9\u79cd\u60c5\u51b5\uff0c\u4e2d\u9014\u653e\u5f03\u7684\u60c5\u51b5\u4e5f\u662f\u6709\u7684\uff0c\u4f46\u662f\u77f3\u5ddd\u8001\u5e08\u8ba4\u771f\u7684\u5206\u79bb\u4e86\u6bcf\u4e2a\u526f\u4ea7\u7269\uff0c\u5e76\u4ed4\u7ec6\u7684\u89e3\u51fa\u4e86\u6bcf\u4e2a\u526f\u4ea7\u7269\u7684\u7ed3\u6784\u3002\u539f\u6765\uff0c\u53cd\u5e94\u7684\u526f\u4ea7\u7269\u662f\u539f\u6599\u5728\u53d1\u751fHWE\u53cd\u5e94(Horner-Wadsworth-Emmons 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Angew. Chem. Int. Ed. 2009, 48, 1304.\u00a0DOI: 10.1002\/anie.200804883. Second generation: Ishikawa, H.; Suzuki,T.; Orita,H.; Uchimaru, T.; Hayashi, Y. Chem. Eur. J. 2010, 16, 12616. DOI: 10.1002\/chem.201001108. Third generation: Mukaiyama, T.; Ishikawa, H.; Koshino, H.; Hayashi, Y. Chem. Eur. J. 2013, 19, 17789. 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