{"id":292,"date":"2014-01-15T19:09:41","date_gmt":"2014-01-15T11:09:41","guid":{"rendered":"\/\/www.gsbet888.com\/?p=292"},"modified":"2019-08-02T18:57:19","modified_gmt":"2019-08-02T10:57:19","slug":"%e7%83%af%e7%83%83%e5%a4%8d%e5%88%86%e8%a7%a3%e5%8f%8d%e5%ba%94%ef%bc%88olefin-metathesis%ef%bc%89","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2014\/01\/%e7%83%af%e7%83%83%e5%a4%8d%e5%88%86%e8%a7%a3%e5%8f%8d%e5%ba%94%ef%bc%88olefin-metathesis%ef%bc%89.html","title":{"rendered":"\u70ef\u70c3\u590d\u5206\u89e3\u53cd\u5e94\uff08Olefin metathesis\uff09"},"content":{"rendered":"<ul>\n<li><strong>\u00a0\u6982\u8981<\/strong><\/li>\n<\/ul>\n<p align=\"left\">\u672c\u53cd\u5e94\u662f\u5229\u7528\u50ac\u5316\u5242\u91d1\u5c5e\u5361\u5bbe\u914d\u5408\u7269\u4f7f\u4e24\u4e2d\u4e0d\u540c\u7684\u70ef\u70c3\u8fde\u63a5\u800c\u4ea7\u751f\u65b0\u7684\u70ef\u70c3\u3002\u56e0\u4e3a\u6b64\u53cd\u5e94\u662f\u5e73\u8861\u53cd\u5e94\uff0c\u8981\u63a7\u5236\u53cd\u5e94\u6761\u4ef6\u4f7f\u5e73\u8861\u5f80\u751f\u6210\u4ea7\u7269\u7684\u65b9\u5411\u79fb\u52a8\uff08\u6bd4\u5982\u9664\u6389\u5728\u53cd\u5e94\u4e2d\u4ea7\u751f\u7684\u4e59\u70ef\u6c14\u4f53\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"olefin_metathesis_2\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_21.gif\" width=\"568\" height=\"170\" \/><\/p>\n<ul>\n<li><strong>\u5386\u53f2\u7531\u6765<\/strong><\/li>\n<\/ul>\n<p>\u57281990\u5e74\u4ee3\uff0c <a href=\"http:\/\/www.chem-station.com\/chemist-db\/archives\/2007\/07\/-robert-h-grubbs.php\"><span style=\"text-decoration: underline\">Robert H.Grubbs<\/span><\/a>\u53d1\u73b0\u4e86\u5b9e\u7528\u6027\u975e\u5e38\u9ad8\u7684\u50ac\u5316\u5242\u3002\u4e4b\u540e\u70ef\u70c3\u590d\u5206\u89e3\u53cd\u5e94\u6210\u4e3a\u6709\u673a\u5408\u6210\u5316\u5b66\u91cc\u6700\u5e38\u7528\u7684\u53cd\u5e94\u4e4b\u4e00\u3002<\/p>\n<p><strong><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_31.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"olefin_metathesis_3\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_31.gif\" width=\"552\" height=\"261\" \/><\/a><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>\u76ee\u524d\u5b9e\u9a8c\u5ba4\u5e38\u7528\u7684\u50ac\u5316\u662f\u901a\u8fc7\u591a\u6b21\u7684\u6539\u5584\u800c\u5f97\u5230\u7684\u3002\u4e0b\u9762\u662f\u73b0\u4eca\u6700\u5e38\u7528\u7684\u50ac\u5316\u5242\u7684\u53cd\u5e94\u5b9e\u4f8b\u3002<\/p>\n<p align=\"left\">\u4e2d\u5fc3\u91d1\u5c5e\u662f\u94bc\u7684\u50ac\u5316\u5242\u79f0Schrock\u50ac\u5316\u5242\u3002\u867d\u7136\u53cd\u5e94\u6027\u6bd4\u8f83\u9ad8\uff0c\u4f46\u5bf9\u6c34\u3001\u8d28\u5b50\u6027\u5316\u5408\u7269\u6216\u7a7a\u6c14\u4e0d\u7a33\u5b9a\u3002\u4f7f\u7528Schrock\u50ac\u5316\u5242\u65f6\u9700\u8981\u7ec6\u5fc3\u3002<\/p>\n<p align=\"left\">Ru-\u4e9a\u82c4\u57fa\u578b\u50ac\u5316\u5242\u79f0Grubbs\u7b2c\u4e00\u4ee3\/\u7b2c\u4e8c\u4ee3\u50ac\u5316\u5242\u3002\u6b64\u50ac\u5316\u5242\u5bf9\u70ef\u70c3\u4ee5\u5916\u7684\u5316\u5408\u7269\u7684\u53cd\u5e94\u6027\u6bd4\u8f83\u4f4e\u3002\u5b98\u80fd\u56e2\u9002\u5e94\u6027\u548c\u7a7a\u6c14\u7684\u7a33\u5b9a\u6027\u90fd\u6bd4\u8f83\u9ad8\u3002Grubbs\u50ac\u5316\u5242\u6bd4Schrock\u50ac\u5316\u5242\u7684\u53cd\u5e94\u6027\u8981\u4f4e\u3002Grubbs\u50ac\u5316\u5242\u4e0d\u80fd\u5229\u7528\u5728\u56db\u53d6\u4ee3\u70ef\u70c3\u7684\u5408\u6210\u3002<\/p>\n<p align=\"left\"><strong><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_41.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"olefin_metathesis_4\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_41.gif\" width=\"402\" height=\"391\" \/><\/a><\/strong><\/p>\n<p align=\"left\">\u867d\u7136\u672c\u53cd\u5e94\u5206\u7c7b\u4e8e\u4eba\u540d\u53cd\u5e94\uff0c\u4f46\u5bf9\u5316\u5b66\u5404\u65b9\u9762\u7684\u5f71\u54cd\u975e\u5e38\u5927\u3002\u53d1\u73b0\u8be5\u53cd\u5e94\u7684<a href=\"http:\/\/www.chem-station.com\/chemist-db\/archives\/2009\/12\/-yves-chauvin.php\">Y.Chauvin<\/a>\u3001<a href=\"http:\/\/www.chem-station.com\/chemist-db\/archives\/2007\/07\/-robert-h-grubbs.php\">R.H.Grubbs<\/a>\uff0c<a href=\"http:\/\/www.chem-station.com\/chemist-db\/archives\/2007\/10\/-richard-rschrock.php\">R.R.Schrock<\/a>\u4e09\u4eba\u56e0\u5176\u5bf9\u73b0\u4ee3\u6709\u673a\u5316\u5b66\u7684\u8d21\u732e\uff0c\u57282005\u5e74\u5f97\u5230\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u3002<\/p>\n<ul>\n<li><strong>\u57fa\u672c\u6587\u732e\u00a0<\/strong><\/li>\n<\/ul>\n<p>&lt;Primitive Reference&gt;<br \/>\n\u30fbCalderon, N.; Chen, H. Y.; Scott, K. W.\u00a0<em>Tetrahedron Lett.<\/em>\u00a0<strong>1967<\/strong>,\u00a0<em>8<\/em>, 3327. DOI:<a href=\"http:\/\/dx.doi.org\/10.1016\/S0040-4039%2801%2989881-6\">10.1016\/S0040-4039(01)89881-6<\/a><br \/>\n\u30fbCalderon, N.\u00a0<em>Acc. Chem. Res.<\/em>\u00a0<strong>1972<\/strong>,\u00a0<em>5<\/em>, 127. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/ar50052a002\">10.1021\/ar50052a002<\/a><\/p>\n<p>&lt;Recent Reviews&gt;<br \/>\n\u30fbTetrahedron Symposia:\u00a0<em>Tetrahedron<\/em>\u00a0<strong>1999<\/strong>,\u00a0<em>55<\/em>, 8141-8162.\u00a0<a href=\"http:\/\/www.sciencedirect.com\/science?_ob=PublicationURL&amp;_tockey=%23TOC%235289%231999%23999449972%23112040%23FLP%23&amp;_cdi=5289&amp;_pubType=J&amp;_auth=y&amp;_acct=C000050221&amp;_version=1&amp;_urlVersion=0&amp;_userid=10&amp;md5=f26ca2e54438369039edae56fe9c69bc\">[link]<\/a><br \/>\n\u30fbF\u00fcrstner, A.\u00a0<em>Angew. Chem. Int. Ed.<\/em>\u00a0<strong>2000<\/strong>,\u00a0<em>39<\/em>, 3012.\u00a0<a href=\"http:\/\/www3.interscience.wiley.com\/cgi-bin\/abstract\/73000798\/ABSTRACT\">[Abstract]<\/a><br \/>\n\u30fbTrnka, T. M.; Grubbs, R. H.\u00a0<em>Acc Chem. Res.<\/em>\u00a0<strong>2001<\/strong>,\u00a0<em>34<\/em>, 18. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/ar000114f\">10.1021\/ar000114f\u00a0<\/a><br \/>\n\u30fbVernall, A. J.; Abell, A. D.\u00a0<em>Aldrichimica acta<\/em>\u00a0<strong>2003<\/strong>,\u00a0<em>36<\/em>, 93.\u00a0<a href=\"http:\/\/www.sigmaaldrich.com\/aldrich\/acta\/al_acta_36_3.pdf\">[PDF]<\/a><br \/>\n\u30fbConnon, S. J.; Blechert, S.\u00a0<em>Angew. Chem. Int. Ed.<\/em>\u00a0<strong>2003<\/strong>,\u00a0<em>42<\/em>, 1900. doi:<a href=\"http:\/\/dx.doi.org\/10.1002\/anie.200200556\">10.1002\/anie.200200556<\/a><br \/>\n\u30fbSchrock, R. R.; Hoveyda, A. H.\u00a0<em>Angew. Chem. Int. Ed.<\/em>\u00a0<strong>2003<\/strong>,\u00a0<em>42<\/em>, 4592. doi:<a href=\"http:\/\/dx.doi.org\/10.1002\/anie.200300576\">10.1002\/anie.200300576<\/a><br \/>\n\u30fbMcReynolds, M. D.; Dougherty, J. M.; Hanson, P. R.\u00a0<em>Chem. Rev.<\/em>\u00a0<strong>2004<\/strong>,\u00a0<em>104<\/em>, 2239. DOI:<a href=\"http:\/\/dx.doi.org\/10.1021\/cr020109k\">10.1021\/cr020109k<\/a><br \/>\n\u30fbGrubbs, R. H.\u00a0<em>Tetrahedron<\/em>\u00a0<strong>2004<\/strong>,\u00a0<em>60<\/em>, 7117. doi:<a href=\"http:\/\/dx.doi.org\/10.1016\/j.tet.2004.05.124\">10.1016\/j.tet.2004.05.124<\/a><br \/>\n\u30fbNicolaou, K. C. et al.\u00a0<em>Angew. Chem. Int. Ed.<\/em>\u00a0<strong>2005<\/strong>,\u00a0<em>44<\/em>, 4490. DOI:<a href=\"http:\/\/dx.doi.org\/10.1002\/anie.200500369%20\">10.1002\/anie.200500369<\/a><br \/>\n\u30fbFlynn, D. L.; Hanson, P. R. et al.\u00a0<em>Aldrichimica acta<\/em>\u00a0<strong>2005<\/strong>,\u00a0<em>38<\/em>, 3.<a href=\"http:\/\/www.sigmaaldrich.com\/aldrich\/acta\/al_acta_38_1.pdf\">\u00a0[PDF]<\/a><br \/>\n\u30fbDonohoe, T. J.; Orr, A. J.; Bingham, M.\u00a0<em>Angew. Chem. Int. Ed.<\/em>\u00a0<strong>2006<\/strong>,\u00a0<em>45<\/em>, 2664. doi:<a href=\"http:\/\/dx.doi.org\/10.1002\/anie.200503512\">10.1002\/anie.200503512<\/a><br \/>\n\u30fbShrodi, Y.; Pederson, R. L.\u00a0<em>Aldrichimica acta<\/em>\u00a0<strong>2007<\/strong>,\u00a0<em>40<\/em>, 45.<a href=\"http:\/\/www.sigmaaldrich.com\/aldrich\/acta\/al_acta_40_02.pdf\">\u00a0[PDF]<\/a><br \/>\n\u30fbHoveyda, A. H.; Zhugralin, A. R.\u00a0<em>Nature<\/em>\u00a0<strong>2007<\/strong>,\u00a0<em>450<\/em>, 243. doi:<a href=\"http:\/\/dx.doi.org\/10.1038\/nature06351\">10.1038\/nature06351<\/a><\/p>\n<p>&lt;Nobel Lectures&gt;<br \/>\n\u30fbChauvin, Y.\u00a0<em>Angew. Chem. Int. Ed.<\/em>\u00a0<strong>2006<\/strong>,\u00a0<em>45<\/em>, 3740. doi:<a href=\"http:\/\/dx.doi.org\/10.1002\/anie.200601234\">10.1002\/anie.200601234<\/a><br \/>\n\u30fbSchrock, R. R.\u00a0<em>Angew. Chem. Int. Ed.<\/em>\u00a0<strong>2006<\/strong>,\u00a0<em>45<\/em>, 3748. doi:<a href=\"http:\/\/dx.doi.org\/10.1002\/anie.200600085\">10.1002\/anie.200600085<\/a><br \/>\n\u30fbGrubbs, R. H.\u00a0<em>Angew. Chem. Int. Ed.<\/em>\u00a0<strong>2006<\/strong>,\u00a0<em>45<\/em>, 3760. doi:<a href=\"http:\/\/dx.doi.org\/10.1002\/anie.200600680\">10.1002\/anie.200600680<\/a><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u53cd\u5e94\u673a\u7406<\/strong><\/li>\n<\/ul>\n<p>\u5728\u8fd9\u91cc\u4ecb\u7ecd\u7684\u50ac\u5316\u5242\u7684\u53cd\u5e94\u673a\u7406\u5927\u81f4\u76f8\u540c (Chauvin Mechanism)\u3002<\/p>\n<p><strong><strong><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_51.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"olefin_metathesis_5\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_51.gif\" width=\"232\" height=\"262\" \/><\/a><\/strong><\/strong><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/li>\n<\/ul>\n<p align=\"left\">\u90a3\u4e9b\u572820\u4e16\u7eaa90\u5e74\u4ee3\u5f00\u53d1\u7684<span style=\"line-height: 1.5em\">\u50ac\u5316\u5242\u4e00\u76f4\u5230\u73b0\u5728\u90fd<\/span><span style=\"line-height: 1.5em\">\u662f\u65e0\u53ef\u6bd4\u62df\u7684\uff0c\u5b83\u4eec\u88ab\u5e7f\u6cdb\u5e94\u7528\u5728\u8bb8\u591a\u7814\u7a76\u9886\u57df\u4e2d\u3002\u8be6\u89c1\u53c2\u8003\u6587\u732e\u3002<\/span>\u672c\u53cd\u5e94\u3002<\/p>\n<p>\u5728\u7cbe\u5bc6\u6709\u673a\u5408\u6210\u548c\u5927\u73af\u5316\u5408\u7269\u7684\u5408\u6210\uff0c\u5173\u73af\u590d\u5206\u89e3\u53cd\u5e94\uff08RCM\uff09\u548c\u5927\u73af\u5185\u916f\u5316\u4e00\u6837\uff0c\u5df2\u6210\u4e3a\u6700\u57fa\u672c\u7684\u5408\u6210\u6cd5\u3002<\/p>\n<p>\u672c\u53cd\u5e94\u7684\u51fa\u73b0\u6539\u53d8\u4e86\u8bb8\u591a\u539f\u6709\u7684\u9006\u5408\u6210\u5206\u6790\uff0c\u4f7f\u53cd\u5e94\u6b65\u9aa4\u7b80\u5316\u3002\u5173\u73af\u590d\u5206\u89e3\u53cd\u5e94\u5177\u6709\u5927\u73af\u5185\u916f\u5316\u6ca1\u6709\u7684\u7279\u5f81\uff0c\u4ee5\u53ca\u76f8\u6bd4\u4e32\u8054\u53cd\u5e94\uff0c\u5728\u591a\u73af\u5316\u5408\u7269\u7684\u5408\u6210\u4e2d\uff0c\u662f\u5f3a\u6709\u529b\u7684\u5c06\u591a\u6b65\u53cd\u5e94\u53d8\u4e3a\u4e00\u6b65\u5408\u6210\u7684\u65b9\u6cd5\u3002<\/p>\n<p><strong><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_62.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"olefin_metathesis_6\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_62.gif\" width=\"419\" height=\"162\" \/><\/a><\/strong><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_7.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-321 aligncenter\" alt=\"olefin_metathesis_7\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_7.gif\" width=\"237\" height=\"88\" \/><\/a><\/p>\n<p>\u70ef\u70c3\u590d\u5206\u89e3\u53cd\u5e94\u50ac\u5316\u5242\u4e0d\u5149\u5bf9\u7cbe\u5bc6\u5408\u6210\u754c\uff0c\u8fd8\u5bf9\u9ad8\u5206\u5b50\u754c\u6210\u4e5f\u6709\u5f88\u5927\u7684\u5f71\u54cd\u3002<\/p>\n<p>\u5229\u7528\u6b64\u50ac\u5316\u5242\u7684\u9ad8\u517c\u5bb9\u6027\u3001\u8fd8\u5b9e\u73b0\u4e86\u5404\u79cd\u591a\u5b98\u80fd\u57fa\u9ad8\u5206\u5b50\u7684\u5408\u6210\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u57fa\u4e8e\u70ef\u70c3\u590d\u5206\u89e3\u53cd\u5e94\u8fd8\u5f00\u53d1\u4e86\u4e00<span style=\"line-height: 1.5em\">\u79cd<\/span><span style=\"line-height: 1.5em\">\u5408\u6210\u73af\u72b6\u805a\u5408\u7269(Cyclic polymer)\u7684<\/span><span style=\"line-height: 1.5em\">\u65b0\u7684\u9ad8\u5206\u5b50\u5408\u6210\u6cd5<\/span><span style=\"line-height: 1.5em\">\u3002<\/span><\/p>\n<p><strong><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_81.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"olefin_metathesis_8\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_81.gif\" width=\"348\" height=\"285\" \/><\/a><\/strong><\/p>\n<p>Hoveyda-Grubbs\u578b\u50ac\u5316\u5242\u901a\u8fc7\u591a\u6b21\u7684\u6539\u826f\u3001\u589e\u5f3a\u4e86\u53cd\u5e94\u6027\u800c\u4e14\u53ef\u4ee5\u5229\u7528\u5728\u56db\u53d6\u4ee3\u70ef\u70c3\u7684\u5408\u6210\u3002[1]\n<p><strong><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_91.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"olefin_metathesis_9\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_91.gif\" width=\"396\" height=\"116\" \/><\/a><\/strong><\/p>\n<p>\u5c06\u5f00\u73af\u590d\u5206\u89e3\u53cd\u5e94\uff08ROM\uff09\u548c\u53cc\u70ef\u73af\u4e01\u70f7\u8f6c\u4f4d\uff08\u5909\u5f62Cope\u8f6c\u4f4d\uff09\u7ec4\u5408\uff0c\u53ef\u7528\u4e8e\u9ad8\u6548\u5408\u6210\u4e8c\u73af\u9aa8\u67b6\u7684\u5316\u5408\u7269\u3002<\/p>\n<p><strong><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_101.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"olefin_metathesis_10\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_101.gif\" width=\"471\" height=\"73\" \/><\/a><\/strong><\/p>\n<p>Gambierol\u7684\u5168\u5408\u6210<\/p>\n<p><strong><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_111.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"olefin_metathesis_11\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_111.gif\" width=\"312\" height=\"226\" \/><\/a><\/strong><\/p>\n<p>\u9ad8\u6d3b\u6027\u7684\u4e0d\u5bf9\u79f0RCM\u50ac\u5316\u5242 [2]\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"olefin_metathesis_12\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/olefin_metathesis_121.gif\" width=\"451\" height=\"179\" \/><\/strong><\/p>\n<p>\u6709Z-\u9009\u62e9\u6027\u7684\u70ef\u70c3\u590d\u5206\u89e3\u53cd\u5e94[3]\n<p><strong><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/Z_methathesis_11.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"Z_methathesis_1\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/Z_methathesis_11.gif\" width=\"375\" height=\"240\" \/><\/a><\/strong><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u5b9e\u9a8c\u6280\u5de7<\/strong><\/li>\n<\/ul>\n<p align=\"left\"><a href=\"http:\/\/allthingsmetathesis.com\/\">\u203b All Things Metathesis<\/a>Grubbs\u5efa\u7acb\u7684\u590d\u5206\u89e3\u53cd\u5e94\u4e13\u4e1a\u521b\u4e1a\u516c\u53f8Materia\u7ba1\u7406\u7684\u535a\u5ba2\u3002\u6b64\u7f51\u7ad9\u7ed9\u6211\u4eec\u63d0\u4f9b\u5404\u79cd\u5404\u6837\u7684\u50ac\u5316\u5242\u7684\u6027\u8d28\u3001\u53cd\u5e94\u6761\u4ef6\u548c\u5dee\u522b\u7b49\u7684\u4fe1\u606f\u3002\u4e3a\u5316\u5b66\u53d1\u5c55\u3002\u5bf9\u54b1\u4eec\u4f5c\u6709\u673a\u5408\u6210\u7684\u4eba\u6709\u5f88\u5927\u7684\u5e2e\u52a9\u3002<\/p>\n<p align=\"left\">\u203b\u867d\u7136\u4f7f\u7528Grubbs\u50ac\u5316\u5242\u65f6\u4e0d\u7528\u60f0\u6027\u6c14\u4f53\u7f6e\u6362\u3001\u4f46\u6b64\u50ac\u5316\u5242\u4f1a\u548c\u6eb6\u5242\u91cc\u542b\u6709\u7684\u6c27\u7acb\u523b\u53cd\u5e94\u800c\u5931\u53bb\u50ac\u5316\u529b\u3002\u6240\u4ee5\u4f7f\u7528\u8131\u6c14\u6eb6\u5242\u80fd\u63d0\u9ad8\u6536\u7387\u3002<\/p>\n<ul>\n<li><strong>\u53c2\u8003\u6587\u732e<\/strong><\/li>\n<\/ul>\n[1] Stewart,I.; Ung, T.; Pletnev, A. A.; Berlin, J. A.; Grubbs, R. H.; Schrodi, Y.\u00a0<em>Org. Lett.<\/em>\u00a0<strong>2007<\/strong>,\u00a0<em>9<\/em>, 1589. DOI:<a href=\"http:\/\/dx.doi.org\/10.1021\/ol0705144\">10.1021\/ol0705144\u00a0<\/a><br \/>\n[2] Malcolmson, S. J.; Meek, S. J.; Sattely, E. S.; Schrock, R. R.; Hoveyda, A. H.\u00a0<em>Nature<\/em>\u00a0<strong>2008<\/strong>, doi:<a href=\"http:\/\/dx.doi.org\/10.1038\/nature07594\">10.1038\/nature07594<\/a><br \/>\n[3] Meek, S. J.; O&#8217;Brien, R. V.; Llaveria, J.; Schrock, R. R.; Hoveyda, A. H.\u00a0<i>Nature<\/i>\u00a0<b>2011<\/b>,\u00a0<i>471<\/i>, 461. doi:<a href=\"http:\/\/dx.doi.org\/10.1038\/nature09957\" target=\"_blank\">10.1038\/nature09957<\/a><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><\/strong><strong>\u76f8\u5173\u4e66\u7c4d<\/strong><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u76f8\u5173\u94fe\u63a5<br \/>\n<\/strong><\/li>\n<\/ul>\n<p>\u30fb<a href=\"http:\/\/images.google.com\/imgres?imgurl=http:\/\/www.sigmaaldrich.com\/img\/assets\/4240\/reag98_re.gif&amp;imgrefurl=http:\/\/www.sigmaaldrich.com\/Brands\/Fluka___Riedel_Home\/Miscellaneous\/Reagent_of_the_Year\/1998.html&amp;h=194&amp;w=219&amp;sz=17&amp;tbnid=curkfXvMiLEJ:&amp;tbnh=90&amp;tbnw=102&amp;hl=ja&amp;start=3&amp;prev=\/images%3Fq%3Drobert%2Bgrubbs%26svnum%3D100%26hl%3Dja%26lr%3D%26oe%3DShift_JIS%26inlang%3Dja%26c2coff%3D1%26sa%3DN\">Reagent of the Year 1998<\/a><br \/>\n\u30fb<a href=\"http:\/\/nobelprize.org\/chemistry\/laureates\/2005\/animation.html\">The Nobel Prize in Chemistry 2005 &#8211; Animation<\/a>\u00a0(Nobelprize.org)<br \/>\n\u30fb<a href=\"http:\/\/www.ilpi.com\/organomet\/olmetathesis.html\" target=\"_blank\">The Organometallic HyperTextBook- Olefin Metathesis<\/a><br \/>\n\u30fb<a href=\"http:\/\/www.sigmaaldrich.com\/Area_of_Interest\/Chemistry\/ChemFiles\/Vol_2_Supplement.html\">Grubbs&#8217; Catalyst<\/a>\uff08Sigma\uff09<br \/>\n\u30fb<a href=\"http:\/\/www.organic-chemistry.org\/frames.htm?http:\/\/www.organic-chemistry.org\/namedreactions\/olefin-metathesis.shtm\">Olefin Metathesis<\/a>\u00a0(organic-chemistry.org)<br \/>\n\u30fb<a href=\"http:\/\/www.organic-chemistry.org\/namedreactions\/ring-opening-metathesis.shtm\">Ring Opening Metathesis<\/a>\u00a0(organic-chemstry.org)<br \/>\n\u30fb<a href=\"http:\/\/www.organic-chemistry.org\/namedreactions\/ring-closing-metathesis.shtm\">Ring-Closing Metathesis<\/a>\u00a0(organic-chemistry.org)<br \/>\n\u30fb<a href=\"http:\/\/www.mpi-muelheim.mpg.de\/kofo\/institut\/arbeitsbereiche\/fuerstner\/pdf\/alkenmethathesis.pdf\">Ring-Crosing Olefin Metathesis: Basic Principles<\/a>\u00a0(PDF)<br \/>\n\u30fb<a href=\"http:\/\/www.pslc.ws\/macrog\/meta.htm\">Olefin Metathesis Polymerization<\/a><br \/>\n\u30fb<a href=\"http:\/\/pubs.acs.org\/cen\/coverstory\/8051\/8051olefin.html\">Olefin Metathesis: Big-Deal Reaction\u00a0<\/a>(C&amp;EN)<br \/>\n\u30fb<a href=\"http:\/\/pubs.acs.org\/cen\/coverstory\/8051\/8051olefin2.html\">Olefin Metathesis: The Early Days<\/a>\u00a0(C&amp;EN)<br \/>\n\u30fb<a href=\"http:\/???%E8%8A%B1%E8%87%A8Afolk.uio.no\/chrisad\/mech.html\">Mechanism of Ru-Catalyzed Olefin Metathesis<\/a><br \/>\n\u30fb<a href=\"http:\/\/en.wikipedia.org\/wiki\/Olefin_metathesis\">Olefin Metathesis<\/a>\u00a0(Wikipedia)<br \/>\n\u30fb<a href=\"http:\/\/www.mpi-muelheim.mpg.de\/kofo\/bericht2002\/pdf\/2.4.1.fuerstner.pdf\">Research Area &#8220;Olefin Metathesis&#8221;<\/a>\u00a0(PDF: A. F\u00fcrster&#8217;s group)<br \/>\n\u30fb<a href=\"http:\/\/www.organik.uni-erlangen.de\/hultzsch\/pdf\/Metathesis.pdf\">Olefin Metathesis<\/a>\u00a0(PDF)<br \/>\n\u30fb<a href=\"http:\/\/media.clarkson.edu\/ChemSem10-16-03\/ChemSemSlide1.htm\">Olefin metathesis and its application in organic synthesis<\/a><br \/>\n\u30fb<a href=\"http:\/\/www.chem.ucalgary.ca\/undergrad\/courses\/f04\/chem531\/OlefinMetathesis.pdf\">Olefin Metathesis Catalyst<\/a>\u00a0(PDF)<br \/>\n\u30fb<a href=\"http:\/\/www.its.caltech.edu\/%7Edmacgrp\/grpmtgs\/2004\/Brown_Grubbs.pdf\">Career of Robert Grubbs<\/a>\u00a0(PDF: MacMillan&#8217;s group)<br \/>\n\u30fb<a href=\"http:\/\/www.its.caltech.edu\/%7Edmacgrp\/grpmtgs\/2000\/WSJ-RCM.pdf\">Olefin Metathesis<\/a>\u00a0(PDF: MacMillan&#8217;s group)<br \/>\n\u30fb<a href=\"http:\/\/www.chem.harvard.edu\/groups\/myers\/handouts\/Metathesis.pdf\">Olefin Metathesis<\/a>\u00a0(PDF: A. Myers&#8217; group)<br \/>\n\u30fb<a href=\"http:\/\/www.isom17.com\/\">17th International Symposium on Olefin Metathesis and Related Chemistry<\/a>\u00a0(ISOM XVII) <\/p>\n","protected":false},"excerpt":{"rendered":"\u00a0\u6982\u8981 \u672c\u53cd\u5e94\u662f\u5229\u7528\u50ac\u5316\u5242\u91d1\u5c5e\u5361\u5bbe\u914d\u5408\u7269\u4f7f\u4e24\u4e2d\u4e0d\u540c\u7684\u70ef\u70c3\u8fde\u63a5\u800c\u4ea7\u751f\u65b0\u7684\u70ef\u70c3\u3002\u56e0\u4e3a\u6b64\u53cd\u5e94\u662f\u5e73\u8861\u53cd\u5e94\uff0c\u8981\u63a7\u5236\u53cd\u5e94\u6761\u4ef6\u4f7f\u5e73\u8861\u5f80\u751f\u6210\u4ea7\u7269\u7684\u65b9\u5411\u79fb\u52a8\uff08\u6bd4\u5982\u9664\u6389\u5728\u53cd\u5e94\u4e2d\u4ea7\u751f\u7684\u4e59\u70ef\u6c14\u4f53\uff09\u3002 \u5386\u53f2\u7531\u6765 \u57281990\u5e74\u4ee3\uff0c Robert H.Grubbs\u53d1\u73b0\u4e86\u5b9e\u7528\u6027\u975e\u5e38\u9ad8\u7684\u50ac\u5316\u5242\u3002\u4e4b\u540e\u70ef\u70c3\u590d\u5206\u89e3\u53cd\u5e94\u6210\u4e3a\u6709\u673a\u5408\u6210\u5316\u5b66\u91cc\u6700\u5e38\u7528\u7684\u53cd\u5e94\u4e4b\u4e00\u3002 &nbsp; \u76ee\u524d\u5b9e\u9a8c\u5ba4\u5e38\u7528\u7684\u50ac\u5316\u662f\u901a\u8fc7\u591a\u6b21\u7684\u6539\u5584\u800c\u5f97\u5230\u7684\u3002\u4e0b\u9762\u662f\u73b0\u4eca\u6700\u5e38\u7528\u7684\u50ac\u5316\u5242\u7684\u53cd\u5e94\u5b9e\u4f8b\u3002 \u4e2d\u5fc3\u91d1\u5c5e\u662f\u94bc\u7684\u50ac\u5316\u5242\u79f0Schrock\u50ac\u5316\u5242\u3002\u867d\u7136\u53cd\u5e94\u6027\u6bd4\u8f83\u9ad8\uff0c\u4f46\u5bf9\u6c34\u3001\u8d28\u5b50\u6027\u5316\u5408\u7269\u6216\u7a7a\u6c14\u4e0d\u7a33\u5b9a\u3002\u4f7f\u7528Schrock\u50ac\u5316\u5242\u65f6\u9700\u8981\u7ec6\u5fc3\u3002 Ru-\u4e9a\u82c4\u57fa\u578b\u50ac\u5316\u5242\u79f0Grubbs\u7b2c\u4e00\u4ee3\/\u7b2c\u4e8c\u4ee3\u50ac\u5316\u5242\u3002\u6b64\u50ac\u5316\u5242\u5bf9\u70ef\u70c3\u4ee5\u5916\u7684\u5316\u5408\u7269\u7684\u53cd\u5e94\u6027\u6bd4\u8f83\u4f4e\u3002\u5b98\u80fd\u56e2\u9002\u5e94\u6027\u548c\u7a7a\u6c14\u7684\u7a33\u5b9a\u6027\u90fd\u6bd4\u8f83\u9ad8\u3002Grubbs\u50ac\u5316\u5242\u6bd4Schrock\u50ac\u5316\u5242\u7684\u53cd\u5e94\u6027\u8981\u4f4e\u3002Grubbs\u50ac\u5316\u5242\u4e0d\u80fd\u5229\u7528\u5728\u56db\u53d6\u4ee3\u70ef\u70c3\u7684\u5408\u6210\u3002 \u867d\u7136\u672c\u53cd\u5e94\u5206\u7c7b\u4e8e\u4eba\u540d\u53cd\u5e94\uff0c\u4f46\u5bf9\u5316\u5b66\u5404\u65b9\u9762\u7684\u5f71\u54cd\u975e\u5e38\u5927\u3002\u53d1\u73b0\u8be5\u53cd\u5e94\u7684Y.Chauvin\u3001R.H.Grubbs\uff0cR.R.Schrock\u4e09\u4eba\u56e0\u5176\u5bf9\u73b0\u4ee3\u6709\u673a\u5316\u5b66\u7684\u8d21\u732e\uff0c\u57282005\u5e74\u5f97\u5230\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u3002 \u57fa\u672c\u6587\u732e\u00a0 &lt;Primitive Reference&gt; \u30fbCalderon, N.; Chen, H. Y.; Scott, K. W.\u00a0Tetrahedron Lett.\u00a01967,\u00a08, 3327. DOI:10.1016\/S0040-4039(01)89881-6 \u30fbCalderon, N.\u00a0Acc. Chem. Res.\u00a01972,\u00a05, 127. DOI:\u00a010.1021\/ar50052a002 &lt;Recent Reviews&gt; \u30fbTetrahedron Symposia:\u00a0Tetrahedron\u00a01999,\u00a055, 8141-8162.\u00a0[link] \u30fbF\u00fcrstner, A.\u00a0Angew. Chem. Int. Ed.\u00a02000,\u00a039, 3012.\u00a0[Abstract] \u30fbTrnka, T. M.; Grubbs, R. H.\u00a0Acc Chem. Res.\u00a02001,\u00a034, 18. DOI:\u00a010.1021\/ar000114f\u00a0 \u30fbVernall, A. J.; Abell, A. D.\u00a0Aldrichimica acta\u00a02003,\u00a036, 93.\u00a0[PDF] \u30fbConnon, S. J.; Blechert, S.\u00a0Angew. Chem. Int. Ed.\u00a02003,\u00a042, 1900. doi:10.1002\/anie.200200556 \u30fbSchrock, R. R.; Hoveyda, A. H.\u00a0Angew. Chem. Int. Ed.\u00a02003,\u00a042, 4592. doi:10.1002\/anie.200300576 \u30fbMcReynolds, M. D.; Dougherty, J. M.; Hanson, P. R.\u00a0Chem. Rev.\u00a02004,\u00a0104, 2239. DOI:10.1021\/cr020109k \u30fbGrubbs, R. H.\u00a0Tetrahedron\u00a02004,\u00a060, 7117. doi:10.1016\/j.tet.2004.05.124 \u30fbNicolaou, K. C. et al.\u00a0Angew. Chem. Int. Ed.\u00a02005,\u00a044, 4490. DOI:10.1002\/anie.200500369 \u30fbFlynn, D. [&hellip;]","protected":false},"author":8,"featured_media":295,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[3,2],"tags":[68,13],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/01\/ene-en7.gif","jetpack_shortlink":"https:\/\/wp.me\/p96op1-4I","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/292"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=292"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/292\/revisions"}],"predecessor-version":[{"id":28299,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/292\/revisions\/28299"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/295"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=292"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}