{"id":29653,"date":"2019-12-03T10:11:09","date_gmt":"2019-12-03T02:11:09","guid":{"rendered":"\/\/www.gsbet888.com\/?p=29653"},"modified":"2019-12-03T10:11:09","modified_gmt":"2019-12-03T02:11:09","slug":"%e5%8d%8e%e4%b8%9c%e7%90%86%e5%b7%a5%e5%a4%a7%e5%ad%a6%e8%8d%af%e5%ad%a6%e9%99%a2%e9%82%93%e5%8d%ab%e5%b9%b3%e6%95%99%e6%8e%88%e8%af%be%e9%a2%98%e7%bb%84angew%ef%bc%9a-pd-tmm%e5%82%ac%e5%8c%96","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2019\/12\/%e5%8d%8e%e4%b8%9c%e7%90%86%e5%b7%a5%e5%a4%a7%e5%ad%a6%e8%8d%af%e5%ad%a6%e9%99%a2%e9%82%93%e5%8d%ab%e5%b9%b3%e6%95%99%e6%8e%88%e8%af%be%e9%a2%98%e7%bb%84angew%ef%bc%9a-pd-tmm%e5%82%ac%e5%8c%96.html","title":{"rendered":"\u534e\u4e1c\u7406\u5de5\u5927\u5b66\u836f\u5b66\u9662\u9093\u536b\u5e73\u6559\u6388\u8bfe\u9898\u7ec4Angew\uff1a Pd-TMM\u50ac\u5316\u4e0d\u5bf9\u79f0[4+3]\u73af\u52a0\u6210\u53cd\u5e94\u5408\u6210\u82ef\u5e76\u544b\u5583[3,2-b]\u6c2e\u6742\u44ec\u9aa8\u67b6"},"content":{"rendered":"

\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n

\u5bfc\u8bfb<\/h4>\n

\u8fd1\u65e5\uff0c\u534e\u4e1c\u7406\u5de5\u5927\u5b66\u836f\u5b66\u9662\u9093\u536b\u5e73\u6559\u6388\u8bfe\u9898\u7ec4<\/strong>\u5728Angew\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e86\u94af\u50ac\u5316\u4e0b\u4e09\u7532\u57fa\u4e59\u70ef\u7532\u70f7\uff08TMM\uff09\u4e0e\u82ef\u5e76\u544b\u5583\u884d\u751f\u7684\u6c2e\u6742\u4e8c\u70ef\u5316\u5408\u7269\u7684\u4e0d\u5bf9\u79f0[4+3]\u73af\u52a0\u6210\u53cd\u5e94\uff0c\u5408\u6210\u82ef\u5e76\u544b\u5583\u6c2e\u6742\u44ec\u884d\u751f\u7269\uff0c\u5177\u6709\u51fa\u8272\u7684\u533a\u57df\u9009\u62e9\u6027\u3001\u7acb\u4f53\u9009\u62e9\u6027\uff08dr>20:1\uff0cee>99\uff05\uff09\u3002\u6b64\u53cd\u5e94\u4ee3\u8868\u7b2c\u4e00\u4e2aPd-TMM\u4e0d\u5bf9\u79f0[4+3]\u73af\u5316\u53cd\u5e94\uff0c\u540c\u65f6\u4e5f\u4e3a\u624b\u6027\u6c2e\u6742\u44ec\u884d\u751f\u7269\u7684\u5408\u6210\u63d0\u4f9b\u4e00\u79cd\u6709\u6548\u7684\u65b9\u6cd5\u3002<\/p>\n

Palladium\u2010Catalyzed Asymmetric [4 + 3] Cyclization of Trimethylenemethane: Regio\u2010, Diastereo\u2010, and Enantioselective Construction of Benzofuro[3,2\u2010b]azepine Skeletons<\/p>\n

Yang-Zi Liu,\u00a0\u00a0Zhongao Wang, Zesheng Huang, Xing Zheng, Wu-Lin Yang, Wei-Ping Deng*<\/p>\n

Angew. Chem. Int. Ed. ASAP DOI\uff1a10.1002\/anie.201909158<\/a><\/p>\n

\"\"<\/a><\/p>\n

\u6b63\u6587<\/h4>\n

Pd-TMM\u73af\u52a0\u6210\u53cd\u5e94\uff0c\u4f5c\u4e3a\u5408\u6210\u73af\u72b6\u5929\u7136\u4ea7\u7269\u7684\u6709\u6548\u65b9\u6848\u3002\u81ea1979\u5e74Trost\u2019s\u63d0\u51fa\u6b64\u65b9\u6848\u4ee5\u6765\uff0cPd-TMM\u4e0e2\u03c0\u4eb2\u5076\u6781\u4f53\u50ac\u5316\u4e0d\u5bf9\u79f0[3+2]\u73af\u52a0\u6210\u53cd\u5e94\uff0c\u5408\u6210\u4e94\u5143\u73af\u9aa8\u67b6\uff08\u5982\u73af\u620a\u70f7\u3001\u56db\u6c22\u544b\u5583\u548c\u5421\u54af\u70f7\u7b49\uff09\u5df2\u88ab\u5927\u91cf\u62a5\u9053\uff08Scheme 1\uff09\u3002\u6b64\u5916\uff0cHayashi\u548cTrost\u8fd8\u6210\u529f\u5730\u5c06\u4e09\u539f\u5b50\u7684\u4eb2\u5076\u6781\u4f53\uff08\u785d\u916e\u548c\u5353\u916e\uff09\u4e0ePd-TMM\u8fdb\u884c\u4e0d\u5bf9\u79f0[3+3]\/[6+3]\u73af\u5316\u53cd\u5e94\uff0c\u5408\u6210\u5177\u6709\u9ad8\u5ea6\u7acb\u4f53\u9009\u62e9\u6027\u7684\u516d\u51431,2-\u6076\u55ea\u548c\u6865\u73af\u5df1\u916e\u884d\u751f\u7269\u3002\u636e\u4f5c\u8005\u6240\u77e5\uff0c\u7531\u4e8e\u4e0d\u5229\u7684\u71b5\u56e0\u5b50\u548c\u8de8\u73af\u76f8\u4e92\u4f5c\u7528\uff0c\u4e03\u5143\u73afPd-TMM\u50ac\u5316\u4e0d\u5bf9\u79f0[4+3]\u73af\u52a0\u6210\u53cd\u5e94\u5c1a\u5f85\u7814\u7a76\u3002\u56e0\u6b64\uff0c\u5229\u7528\u5177\u6709\u56db\u539f\u5b50\u4eb2\u5076\u6781\u4f53\u4e0ePd-TMM\u7684\u4e0d\u5bf9\u79f0[4+3]\u73af\u52a0\u6210\u4ecd\u5177\u6709\u6311\u6218\u3002<\/p>\n

\u6b64\u5916\uff0c\u624b\u6027\u6c2e\u6742\u44ec\uff08\u4e03\u5143\u6c2e\u6742\u73af\uff09\u4f5c\u4e3a\u5929\u7136\u4ea7\u7269\u53ca\u836f\u7269\u57fa\u672c\u9aa8\u67b6\uff0c\u800c\u901a\u8fc7\u7b80\u4fbf\u7684\u65b9\u6cd5\u4e00\u6b65\u5408\u6210\u5177\u6709\u9ad8\u5bf9\u6620\u4f53\u9009\u62e9\u6027\u7684\u624b\u6027\u4ea7\u54c1\uff0c\u4e00\u76f4\u4f5c\u4e3a\u91cd\u8981\u7684\u7814\u7a76\u9886\u57df\u3002\u5728\u53ef\u884c\u7684\u65b9\u6cd5\u4e2d\uff0c\u7531\u4e8e[4+3]\u73af\u5316\u5177\u6709\u8f83\u9ad8\u7684\u539f\u5b50\u7ecf\u6d4e\u6027\uff0c\u4f46\u4ec5\u6709\u5c11\u91cf\u6587\u732e\u62a5\u9053\u3002\u7136\u800c\uff0c\u8003\u8651\u5230\u751f\u7269\u6d3b\u6027\u7684\u624b\u6027\u6c2e\u6742\u44ec\u7684\u7ed3\u6784\u591a\u6837\u6027\uff0c\u5f00\u53d1\u65b0\u578b\u50ac\u5316\u4e0d\u5bf9\u79f0[4+3]\u73af\u52a0\u6210\u53cd\u5e94\u4ecd\u7136\u5f88\u91cd\u8981\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e3a\u4e86\u5b9e\u73b0\u4e0a\u8ff0\u76ee\u6807\uff0c\u4f5c\u8005\u8bbe\u60f3\uff0c\u901a\u8fc7\u6c2e\u6742\u4e8c\u70ef\uff08\u82b3\u6784\u5316\u4f5c\u7528\u4fc3\u4f7f1,4-\u5076\u6781\u5171\u632f\u7ed3\u6784RS I<\/strong>\uff0c\u5145\u5f534\u03c0\u6210\u5206\uff09\u4e0ePd-TMM\u53d1\u751f\u4e0d\u5bf9\u79f0[4+3]\u73af\u52a0\u6210\u53cd\u5e94\uff0c\u5408\u6210\u82ef\u5e76\u544b\u5583\u6c2e\u6742\u44ec\u884d\u751f\u7269\uff08Scheme 2\uff09\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\u5e94\u8003\u8651\u4e24\u4e2a\u95ee\u9898\uff0c\uff081\uff09\u4e9a\u80fa\u6216\u70ef\u70c3[3+2]\u73af\u52a0\u6210\u7684\u7ade\u4e89\u6027\u5bfc\u81f4\u533a\u57df\u9009\u62e9\u6027\uff0c\uff082\uff09\u53cd\u5e94\u6027\u548c\u975e\u5bf9\u6620\u6216\u5bf9\u6620\u9009\u62e9\u6027\u4e4b\u95f4\u7684\u6298\u4e2d\u5173\u7cfb\u3002\u4e3a\u89e3\u51b3\u8fd9\u4e9b\u6311\u6218\uff0c\u4f5c\u8005\u5728\u6b64\u62a5\u544a\u4e86\uff0c\u94af\u50ac\u5316\u82ef\u5e76\u544b\u5583\u884d\u751f\u7684\u6c2e\u6742\u4e8c\u6c2e\u70ef\u4e0eTMM\u4f9b\u4f53\u7684\u4e0d\u5bf9\u79f0[4+3]\u73af\u52a0\u6210\u53cd\u5e94\uff0c\u6784\u5efa\u4e86\u591a\u79cd\u5177\u6709\u9ad8\u975e\u5bf9\u6620\u9009\u62e9\u6027\u548c\u5bf9\u6620\u9009\u62e9\u6027\u7684\u82ef\u5e76\u544b\u5583[3,2-b<\/em>]\u6c2e\u6742\u44ec\u9aa8\u67b6\u3002\u8be5\u53cd\u5e94\u4e0d\u4ec5\u4ee3\u8868\u4e86Pd-TMM\u50ac\u5316\u4e0d\u5bf9\u79f0[4+3]\u73af\u52a0\u6210\u53cd\u5e94\u7684\u7b2c\u4e00\u4e2a\u4f8b\u5b50\uff0c\u540c\u65f6\u8fd8\u63d0\u4f9b\u4e86\u4e00\u79cd\u5408\u6210\u624b\u6027\u7a20\u5408\u6c2e\u6742\u44ec\u7684\u6709\u6548\u65b9\u6cd5\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u9996\u5148\uff0c\u4f5c\u8005\u4ee5Pd2<\/sub>(dba)3<\/sub>\u4e3a\u50ac\u5316\u5242\uff0cL1<\/strong>\u4e3a\u914d\u4f53\uff0c\u572835\u00a0o<\/sup>C\u7532\u82ef\u6eb6\u6db2\u4e2d\uff0c\u7814\u7a76\u4e86\u6c28\u57fa-TMM\u4f9b\u4f531a<\/strong>\u4e0e\u82ef\u5e76\u544b\u5583\u884d\u751f\u7684\u6c2e\u6742\u4e8c\u70ef2a<\/strong>\u7684\u53cd\u5e94\uff08Table 1\uff09\u3002\u53cd\u5e94\u7ed3\u679c\u4e0e\u9884\u671f\u4e00\u81f4\uff0c\u83b7\u5f9795\uff05\u6536\u7387\u7684\u987a\u5f0f3aa<\/strong>\uff0c\u5177\u6709\u51fa\u8272\u7684\u975e\u5bf9\u6620\u9009\u62e9\u6027\uff08dr>20:1\uff09\u548c\u5bf9\u6620\u9009\u62e9\u6027\uff08ee=96\uff05\uff09\uff0c\u800c\u6ca1\u6709\u4efb\u4f55[3+2]\u73af\u5316\u4ea7\u7269\u7684\u751f\u6210\u3002\u800c\u5728\u7b5b\u9009\u5176\u5b83\u624b\u6027\u81a6\u914d\u4f53\u65f6\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c\u5728\u6c2e\u539f\u5b50\u4e0a\u5177\u6709\u4e0d\u540c\u53d6\u4ee3\u57fa\u7684\u4e9a\u78f7\u9170\u80fa\u914d\u4f53\u65f6\uff0c\u5bf9\u6620\u9009\u62e9\u6027\u53d7\u5230\u5f71\u54cd\u3002\u4f7f\u7528L2<\/strong>–L4<\/strong>\u914d\u4f53\u65e0\u6cd5\u83b7\u5f97\u66f4\u597d\u7684\u7ed3\u679c\uff0c\u4e8c\u81a6\u914d\u4f53L5<\/strong>–L6<\/strong>\u65e0\u6cd5\u8fdb\u884c[4+3]\u73af\u52a0\u6210\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u5c06\u53cd\u5e94\u6e29\u5ea6\u964d\u4f4e\u81f325\u2103\u65f6\uff0c\u53ef\u8fdb\u4e00\u6b65\u63d0\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u5728\u83b7\u5f97\u4e0a\u8ff0\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u540e\uff0c\u4f5c\u8005\u5f00\u59cb\u5bf9\u5e95\u7269\u8fdb\u884c\u4e86\u6269\u5c55\u3002\u9996\u5148\uff0c\u4f5c\u8005\u5bf9\u5e95\u7269\u82ef\u5e76\u544b\u5583\u884d\u751f\u7684\u6c2e\u6742\u4e8c\u70ef2<\/strong>\u4e0e\u6c28\u57fa-TMM\u4f9b\u4f531a<\/strong>\u8fdb\u884c\u4e86\u53cd\u5e94\u7814\u7a76\uff08Table 2\uff09\u3002\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u82ef\u5e76\u544b\u5583\u884d\u751f\u7684\u6c2e\u6742\u4e8c\u70ef2<\/strong>\u4e0aR1<\/sup>\u57fa\u56e2\u4e0d\u53d7\u7535\u5b50\u6548\u5e94\u5f71\u54cd\uff0c\u5747\u4e0e\u4e0e\u6c28\u57fa-TMM\u4f9b\u4f531a<\/strong>\u987a\u5229\u53cd\u5e94\uff0c\u83b7\u5f97\u9ad8\u6536\u7387\u3001\u9ad8\u975e\u5bf9\u6620\u4f53\u9009\u62e9\u6027\u548c\u9ad8\u5bf9\u6620\u4f53\u9009\u62e9\u6027\u76843aa<\/strong>–3ao<\/strong>\u3002\u540c\u65f6\uff0c\u70f7\u57fa\u53d6\u4ee32p<\/strong>\u4e5f\u9002\u7528\u4e8e\u8be5\u53cd\u5e94\uff08entry 16\uff09\u3002\u6b64\u5916\uff0c\u82ef\u5e76\u544b\u5583\u884d\u751f\u7684\u6c2e\u6742\u4e8c\u70ef2<\/strong>\u4e0aR2<\/sup>\u57fa\u56e2\u4e5f\u4e0d\u53d7\u7535\u5b50\u6548\u5e94\u5f71\u54cd\uff0c\u540c\u6837\u83b7\u5f97\u9009\u62e9\u6027\u9ad8\u76843aq<\/strong>–3av<\/strong>\uff08entries 17-22\uff09\u3002\u901a\u8fc7R3<\/sup>\u4e0a\u53d6\u4ee3\u57fa\u7684\u6539\u53d8\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c\u78fa\u9170\u57fa\u5bf9\u9ad8\u53cd\u5e94\u6027\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\uff08entries 23-24\uff09\u3002<\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

\u603b\u7ed3<\/h4>\n

\u534e\u4e1c\u7406\u5de5\u5927\u5b66\u836f\u5b66\u9662\u9093\u536b\u5e73\u6559\u6388\u8bfe\u9898\u7ec4\u5efa\u7acb\u4e86\u9ad8\u6548\u7684Pd-TMM\u4e0e\u82ef\u5e76\u544b\u5583\u884d\u751f\u7684\u6c2e\u6742\u4e8c\u70ef\u4e0d\u5bf9\u79f0[4+3]\u73af\u5316\u53cd\u5e94\uff0c\u4ee5\u4f18\u5f02\u7684\u6536\u7387\u3001\u9ad8\u975e\u5bf9\u6620\u9009\u62e9\u6027\u548c\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\uff0c\u83b7\u5f97\u624b\u6027\u82ef\u5e76\u544b\u5583[3,2-b<\/em>]\u6c2e\u6742\u44ec\u884d\u751f\u7269\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u6b64\u8fc7\u7a0b\u4e2d\uff0c\u4f7f\u75281a<\/strong>\u548c1b<\/strong>\u4e24\u79cd\u4e0d\u540cTMM\u4f9b\u4f53\uff0c\u83b7\u5f97\u76f8\u53cd\u7684\u6784\u578b\u7684\u4ea7\u7269\u3002\u6700\u91cd\u8981\u7684\u662f\uff0c\u6b64\u53cd\u5e94\u4ee3\u8868\u7b2c\u4e00\u4e2aPd-TMM\u4e0d\u5bf9\u79f0[4+3]\u73af\u5316\u53cd\u5e94\uff0c\u540c\u65f6\u4e5f\u4e3a\u624b\u6027\u6c2e\u6742\u44ec\u884d\u751f\u7269\u7684\u5408\u6210\u63d0\u4f9b\u4e00\u79cd\u6709\u6548\u7684\u65b9\u6cd5\u3002<\/p>\n

\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<\/strong>Chem-Station\u5316\u5b66\u7a7a\u95f4<\/strong><\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb \u8fd1\u65e5\uff0c\u534e\u4e1c\u7406\u5de5\u5927\u5b66\u836f\u5b66\u9662\u9093\u536b\u5e73\u6559\u6388\u8bfe\u9898\u7ec4\u5728Angew\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e86\u94af\u50ac\u5316\u4e0b\u4e09\u7532\u57fa\u4e59\u70ef\u7532\u70f7\uff08TMM\uff09\u4e0e\u82ef\u5e76\u544b\u5583\u884d\u751f\u7684\u6c2e\u6742\u4e8c\u70ef\u5316\u5408\u7269\u7684\u4e0d\u5bf9\u79f0[4+3]\u73af\u52a0\u6210\u53cd\u5e94\uff0c\u5408\u6210\u82ef\u5e76\u544b\u5583\u6c2e\u6742\u44ec\u884d\u751f\u7269\uff0c\u5177\u6709\u51fa\u8272\u7684\u533a\u57df\u9009\u62e9\u6027\u3001\u7acb\u4f53\u9009\u62e9\u6027\uff08dr>20:1\uff0cee>99\uff05\uff09\u3002\u6b64\u53cd\u5e94\u4ee3\u8868\u7b2c\u4e00\u4e2aPd-TMM\u4e0d\u5bf9\u79f0[4+3]\u73af\u5316\u53cd\u5e94\uff0c\u540c\u65f6\u4e5f\u4e3a\u624b\u6027\u6c2e\u6742\u44ec\u884d\u751f\u7269\u7684\u5408\u6210\u63d0\u4f9b\u4e00\u79cd\u6709\u6548\u7684\u65b9\u6cd5\u3002 Palladium\u2010Catalyzed Asymmetric [4 + 3] Cyclization of Trimethylenemethane: Regio\u2010, Diastereo\u2010, and Enantioselective Construction of Benzofuro[3,2\u2010b]azepine Skeletons Yang-Zi Liu,\u00a0\u00a0Zhongao Wang, Zesheng Huang, Xing Zheng, Wu-Lin Yang, Wei-Ping Deng* Angew. Chem. Int. Ed. 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