{"id":30112,"date":"2020-02-05T15:00:41","date_gmt":"2020-02-05T07:00:41","guid":{"rendered":"\/\/www.gsbet888.com\/?p=30112"},"modified":"2020-02-06T19:41:55","modified_gmt":"2020-02-06T11:41:55","slug":"%e6%9c%89%e6%9c%9b%e6%88%90%e4%b8%ba%e6%8a%97%e5%87%bb%e6%96%b0%e5%9e%8b%e5%86%a0%e7%8a%b6%e7%97%85%e6%af%92%e6%96%b0%e8%8d%af%e7%9a%84remdesivir%e5%8f%8a%e8%83%8c%e5%90%8e%e7%9a%84protide%e6%8a%80","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2020\/02\/%e6%9c%89%e6%9c%9b%e6%88%90%e4%b8%ba%e6%8a%97%e5%87%bb%e6%96%b0%e5%9e%8b%e5%86%a0%e7%8a%b6%e7%97%85%e6%af%92%e6%96%b0%e8%8d%af%e7%9a%84remdesivir%e5%8f%8a%e8%83%8c%e5%90%8e%e7%9a%84protide%e6%8a%80.html","title":{"rendered":"\u6709\u671b\u6210\u4e3a\u6297\u51fb\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u65b0\u836f\u7684Remdesivir\u53ca\u80cc\u540e\u7684ProTide\u6280\u672f"},"content":{"rendered":"<p>\u672c\u6587\u4f5c\u8005\uff1a\u8283\u6d0b\u96ea<\/p>\n<p>2020\u5e74\u6625\u8282\u662f\u4e2a\u4e0d\u5e73\u51e1\u7684\u65b0\u5e74\uff0c\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e\u8086\u8650\u4e86\u534e\u590f\u5927\u5730\u3002\u75c5\u6bd2\u8fd9\u79cd\u5fae\u5c0f\u7684\u7269\u79cd\uff0c\u5e73\u65f6\u9690\u533f\u4e0d\u89c1\u9ed8\u9ed8\u6f5c\u4f0f\u7740\uff0c\u53ef\u662f\u4e00\u65e6\u5728\u67d0\u4e2a\u65f6\u95f4\u7206\u53d1\uff0c\u77ac\u95f4\u5c31\u5f15\u8d77\u6781\u5927\u7684\u5173\u6ce8\uff0c\u50ac\u751f\u4e86\u761f\u75ab\u8fd9\u4e2a\u53ef\u6015\u7684\u6740\u624b\uff0c\u4e0d\u4ec5\u9020\u6210\u8089\u4f53\u4e0a\u7684\u635f\u4f24\uff0c\u8fd8\u5f15\u53d1\u7cbe\u795e\u4e0a\u7684\u6050\u614c\u3002\u4eca\u5e74\u6625\u8282\u5047\u671f\u9664\u5728\u5bb6\u5f85\u7740\u4e0d\u968f\u4fbf\u5916\u51fa\uff0c\u5e26\u53e3\u7f69\u3001\u52e4\u6d17\u624b\u7b49\u81ea\u6211\u4fdd\u62a4\u63aa\u65bd\u5916\uff0c\u6709\u6ca1\u6709\u53ef\u4ee5\u6297\u8fd9\u6b21\u75c5\u6bd2\u7684\u836f\u7269\u4e5f\u662f\u5927\u5bb6\u5173\u5fc3\u7684\u95ee\u9898\u3002\u5728\u8fd9\u6bb5\u65f6\u95f4\uff0c\u4e5f\u4e0d\u65ad\u6709\u597d\u6d88\u606f\u4f20\u51fa\uff0c\u4f8b\u5982\u56fd\u5bb6\u536b\u5065\u59d4\u5c06\u6cbb\u7597\u827e\u6ecb\u75c5\u7684\u86cb\u767d\u9176\u6291\u5236\u5242\u6d1b\u5339\u90a3\u97e6\/\u5229\u6258\u90a3\u97e6\u7247\uff08\u514b\u529b\u829d\uff09\u7eb3\u5165\u8bd5\u884c\u6cbb\u7597\u65b9\u6848\u3002\u968f\u540e\u53c8\u6709Gilead Science\u5409\u5229\u5fb7\u79d1\u5b66\u7684\u4e34\u5e8a\u65b0\u836f<span style=\"color: #00ff00;\"><strong>Remdesivir<\/strong><\/span>\u6297\u51fb\u51a0\u72b6\u75c5\u6bd2\u6709\u6548\uff0c\u90a3\u4e48\u5b83\u53c8\u662f\u4f55\u65b9\u795e\u5723\u5462\uff1f<sup>[1]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/1-5.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30113 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/1-5.png\" alt=\"\" width=\"404\" height=\"385\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/1-5.png 523w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/1-5-300x286.png 300w\" sizes=\"(max-width: 404px) 100vw, 404px\" \/><\/a><\/p>\n<p>\u5982\u679c\u6211\u4eec\u518d\u8ba4\u8bc6\u4e00\u4e0b\u4ec0\u4e48\u662f\u75c5\u6bd2\u5c31\u4e0d\u96be\u7406\u89e3\u3002\u75c5\u6bd2\u662f\u7531\u4e00\u4e2a\u6838\u9178\u5206\u5b50\uff08DNA\u6216RNA\uff09\u4e0e\u86cb\u767d\u8d28\u6784\u6210\u7684\u975e\u7ec6\u80de\u5f62\u6001\uff0c\u9760\u5bc4\u751f\u751f\u6d3b\u3002\u75c5\u6bd2\u4e0d\u662f\u7ec6\u80de\uff0c\u4e5f\u5c31\u65e0\u6cd5\u901a\u8fc7\u7ec6\u80de\u5206\u88c2\u7684\u5f62\u5f0f\u5b8c\u6210\u7e41\u6b96\uff0c\u5b83\u4eec\u5229\u7528\u5bbf\u4e3b\u7ec6\u80de\u5185\u7684\u7269\u8d28\u5b8c\u6210\u81ea\u8eab\u7684\u62f7\u8d1d\uff0c\u5e76\u5b8c\u6210\u75c5\u6bd2\u7684\u7ec4\u88c5\uff0c\u518d\u91ca\u653e\u51fa\u53bb\u3002\u5728\u62f7\u8d1d\u8fc7\u7a0b\u4e2d\uff0c\u5404\u79cd\u6838\u82f7\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\u6210\u5206\uff0c\u56e0\u6b64\u6838\u82f7\u7c7b\u5c31\u6709\u53ef\u80fd\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u836f\u7269\uff0c\u4e8b\u5b9e\u4e5f\u786e\u5b9e\u5982\u6b64\u3002\u6838\u82f7\u7c7b\u836f\u7269\u5728\u6297\u80bf\u7624\u3001\u548c\u6297\u75c5\u6bd2\uff08\u5982HIV\u827e\u6ecb\u3001HBV\u4e59\u809d\u3001HCV\u4e19\u809d)\u7b49\u9886\u57df\u5e94\u7528\u5e7f\u6cdb\uff0c\u5176\u4f5c\u7528\u9776\u70b9\u591a\u4e3aDNA \u805a\u5408\u9176\u6216RNA\u9006\u8f6c\u5f55\u9176\u3002\u6838\u82f7\u7c7b\u836f\u7269\u56e0\u6a21\u62df\u5929\u7136\u6838\u82f7\u7684\u7ed3\u6784, \u53ef\u4ee5\u7ade\u4e89\u6027\u5730\u4f5c\u7528\u4e8e\u9176\u6d3b\u6027\u4e2d\u5fc3, \u5d4c\u5165\u6b63\u5728\u5408\u6210\u7684DNA \u6216RNA\u94fe\u4e2d, \u5e72\u6270\u6838\u9178\u4ee3\u8c22\u3002\u6838\u82f7\u7c7b\u836f\u7269\u5e76\u975e\u771f\u6b63\u7684\u6d3b\u6027\u6210\u5206\uff0c\u5b83\u4eec\u5728\u5728\u7ec6\u80de\u5185\u7ecf\u9176\u6d3b\u5316, \u8f6c\u5316\u4e3a\u4e8c\u78f7\u9178\u6216\u4e09\u78f7\u9178\u884d\u751f\u7269\u540e\u624d\u53d1\u6325\u4f5c\u7528\uff0c\u5982\u56fe1\u6240\u793a<sup>[2]<\/sup>\u3002 \u5176\u4e2d\u5f15\u5165\u7b2c\u4e00\u4e2a\u78f7\u9178\u662f\u9650\u901f\u6b65\u9aa4, \u6240\u4ee5\u5728\u6838\u82f7\u7c7b\u836f\u7269\u4e2d\u5148\u5f15\u5165\u4e00\u4e2a\u78f7\u9178\u6216\u78f7\u9178\u916f\u57fa\u56e2\uff0c\u7ed5\u8fc7\u9650\u901f\u6b65\u9aa4\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/2-7.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30114 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/2-7.png\" alt=\"\" width=\"819\" height=\"251\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/2-7.png 1160w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/2-7-300x92.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/2-7-768x235.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/2-7-680x208.png 680w\" sizes=\"(max-width: 819px) 100vw, 819px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe1 \u6838\u82f7\u7c7b\u836f\u7269NA\u5728\u4f53\u5185\u78f7\u9178\u5316<\/p>\n<p>\u867d\u7136\u5f15\u5165\u78f7\u9178\u6216\u78f7\u9178\u916f\u89e3\u51b3\u4e86\u8fd9\u4e2a\u9650\u901f\u95ee\u9898\uff0c\u4f46\u65e9\u671f\u8bbe\u8ba1\u7684\u78f7\u9178\u6216\u78f7\u9178\u916f\u884d\u751f\u7269\u5b58\u5728\u4e24\u5927\u95ee\u9898\uff1a1\u3001\u78f7-\u6c27\u952e\u7a33\u5b9a\u6027\u8f83\u5dee, \u6613\u88ab\u8840\u6d46\u4e2d\u7684\u9176\u8131\u53bb\u78f7\u9178 \u30022\u3001\u78f7\u9178\u57fa\u56e2\u5728\u6c34\u6eb6\u6db2\u4e2d\u89e3\u79bb\u540e\u5e26\u6709\u7535\u8377\uff0c\u6781\u6027\u5927, \u96be\u4ee5\u900f\u8fc7\u7ec6\u80de\u819c\u3002<\/p>\n<p>\u7ecf\u8fc7\u836f\u7269\u5316\u5b66\u5bb6\u4eec\u591a\u5e74\u52aa\u529b\uff0c\u4e00\u79cdProTide\u524d\u836f\u6280\u672f\u5b8c\u7f8e\u7684\u89e3\u51b3\u4e86\u8fd9\u4e24\u5927\u95ee\u9898\u3002\u524d\u836f\u662f\u6307\u4e00\u4e9b\u5728\u4f53\u5916\u6d3b\u6027\u8f83\u5c0f\u6216\u8005\u65e0\u6d3b\u6027\u7684\u5316\u5408\u7269\uff0c\u5728\u4f53\u5185\u7ecf\u8fc7\u9176\u7684\u50ac\u5316\u6216\u8005\u975e\u9176\u4f5c\u7528\uff0c\u91ca\u653e\u51fa\u6d3b\u6027\u7269\u8d28\u4ece\u800c\u53d1\u6325\u5176\u836f\u7406\u4f5c\u7528\u7684\u5316\u5408\u7269\u3002\u901a\u8fc7\u524d\u836f\u4fee\u9970\u53ef\u4ee5\u6539\u5584\u836f\u7269\u7684\u7406\u5316\u6027\u8d28, \u63d0\u9ad8\u836f\u7269\u7684\u4f20\u8f93\u901f\u7387\u548c\u9009\u62e9\u6027\u7b49\u95ee\u9898\u3002<\/p>\n<p>ProTide(\u6e90\u4e8e<strong>Pro<\/strong>drug\uff0bnucleo<strong>Tide<\/strong>)\u5373\u524d\u836f+\u6838\u82f7\u6280\u672f\uff0c\u662f1990s\u7531<strong>Cardiff University\u5361\u8fea\u592b\u5927\u5b66\u836f\u5b66\u9662\u7684Chris McGuigan<\/strong> (1958-2016)\u6559\u6388\u9886\u5bfc\u7684\u56e2\u961f\u9996\u5148\u53d1\u5c55\u8d77\u6765\u7684\u3002\u5176\u6280\u672f\u6838\u5fc3\u662f\u7528\u4e00\u4e2a\u82b3\u9999\u53d6\u4ee3\u57fa\u548c\u4e00\u4e2a\u6c28\u57fa\u9178\u916f\u7ec4\u6210\u7684\u7ed3\u6784\u4ee5\u78f7\u9170\u80fa\u916f\u7684\u5f62\u5f0f\u5c06\u78f7\u9178\u57fa\u56e2\u4fdd\u62a4\u8d77\u6765\uff0c\u5c4f\u853d\u5176\u6781\u6027\uff0c\u4f7f\u5176\u6709\u6548\u5730\u4f20\u8f93\u8fdb\u5165\u7ec6\u80de\u5185\uff0c\u518d\u5728\u7ec6\u80de\u5185\u5404\u79cd\u9176\u7684\u4f5c\u7528\u4e0b\u5c06\u78f7\u9178\u57fa\u56e2\u91ca\u653e\u51fa\u6765\u3002\u5177\u4f53\u673a\u7406\u5982\u4e0b\u56fe2\u6240\u793a\uff0c\u9996\u5148\u6c28\u57fa\u9178\u7fa7\u57fa\u7684\u916f\u952e\u5728\u916f\u9176\u4f5c\u7528\u4e0b\u6c34\u89e3\uff0c\u751f\u6210\u7684\u6e38\u79bb\u7fa7\u57fa\u901a\u8fc7\u5206\u5b50\u5185\u7684\u534f\u540c\u6210\u73af\u53cd\u5e94\u751f\u6210\u4e94\u5143\u73af\uff0c\u4fc3\u8fdb\u915a\u916f\u6c34\u89e3\uff0c\u7136\u540e\u4e94\u5143\u73af\u7684\u8fc7\u6e21\u4e2d\u95f4\u4f53\u6c34\u89e3\uff0c\u751f\u6210\u5355\u78f7\u9170\u80fa\u4e2d\u95f4\u4f53\uff0c\u540e\u8005\u7ee7\u7eed\u5728\u78f7\u9170\u80fa\u9176\u4f5c\u7528\u4e0b\u6216\u5728\u9178\u6027\u6761\u4ef6\u4e0b\u518d\u6b21\u6c34\u89e3\uff0c\u6700\u7ec8\u751f\u6210\u6838\u82f7\u78f7\u9178\/\u78f7\u9178\u7c7b\u4f3c\u7269<sup>[3]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/3-8.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30115 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/3-8.png\" alt=\"\" width=\"846\" height=\"569\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/3-8.png 1245w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/3-8-300x202.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/3-8-768x516.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/3-8-680x457.png 680w\" sizes=\"(max-width: 846px) 100vw, 846px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe2 ProTide\u91ca\u653e\u78f7\u9178\u7684\u673a\u7406<\/p>\n<p>\u7531\u6b64\uff0c\u4ee5\u6297\u827e\u6ecb\/\u4e59\u809d\u7684<span style=\"color: #00ff00;\"><strong>\u66ff\u8bfa\u798f\u97e6\u827e\u62c9\u915a<\/strong><\/span>\u548c\u6297\u4e19\u809d\u795e\u836f\u7684<span style=\"color: #00ff00;\"><strong>\u7d22\u83f2\u5e03\u97e6<\/strong><\/span>\u4e3a\u4ee3\u8868\u7684ProTide\u6838\u82f7\u836f\u7269\u6b63\u5f0f\u767b\u573a\uff0c\u4e5f\u7a33\u5b9a\u4e86\u5409\u5229\u5fb7\u79d1\u5b66\u5728\u6297\u75c5\u6bd2\u9886\u57df\u4e2d\u7684\u738b\u8005\u5730\u4f4d\uff0c\u4ece\u7ed3\u6784\u7279\u70b9\u4e0a\u770b\u672c\u6587\u7684\u4e3b\u89d2<span style=\"color: #00ff00;\"><strong>Remdesivir<\/strong><\/span>\u4e5f\u662f\u91c7\u7528\u4e86ProTide\u524d\u836f\u6280\u672f\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/4-7.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30116 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/4-7.png\" alt=\"\" width=\"823\" height=\"476\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/4-7.png 979w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/4-7-300x173.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/4-7-768x444.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/01\/4-7-680x393.png 680w\" sizes=\"(max-width: 823px) 100vw, 823px\" \/><\/a><\/p>\n<p>2014\u5e74\u975e\u6d32\u897f\u90e8\u7206\u53d1\u4e86\u57c3\u535a\u62c9\u75c5\u6bd2Ebola virus\uff0c\u636eWHO2016\u5e74\u7684\u7edf\u8ba1\uff0c\u4ec5\u975e\u6d32\u897f\u90e8\u5c31\u786e\u8bca\u4e8628616\u4f8b\u611f\u67d3\uff0c\u9020\u621011310\u4f8b\u6b7b\u4ea1\uff0c\u6b7b\u4ea1\u7387\u975e\u5e38\u9ad8\u3002\u622a\u6b62\u76ee\u524d\u4e5f\u6ca1\u6709\u6cbb\u7597\u57c3\u535a\u62c9\u7684\u7279\u6548\u836f\uff0c\u5012\u662f\u5409\u5229\u5fb7\u79d1\u5b66\u7684GS-5734\u663e\u793a\u4e86\u79ef\u6781\u7684\u6548\u679c\u3002GS-5734\u5373<span style=\"color: #00ff00;\"><strong>Remdesivir<\/strong><\/span>\u662f\u5409\u5229\u5fb7\u79d1\u5b66\u5f00\u53d1\u7684Adenosine\u817a\u82f7\u7c7b\u4f3c\u7269\uff0c\u5e76\u91c7\u7528\u4e86ProTide\u524d\u836f\u6280\u672f\uff0c\u88ab\u7ec6\u80de\u6444\u5165\u540e\uff0c\u4ee3\u8c22\u4e3a\u5177\u6709\u836f\u7406\u6d3b\u6027\u7684\u4e09\u78f7\u9178\u5f62\u5f0f\uff0c\u6291\u5236\u591a\u79cdRNA\u4f9d\u8d56\u7684RNA\u805a\u5408\u9176\u3002\u867d\u7136\u8fd9\u4e2a\u836f\u7269\u5927\u591a\u662f\u56e0\u4e3a\u57c3\u535a\u62c9\u75c5\u6bd2\u53d7\u5230\u5173\u6ce8\uff0c\u5176\u5b9e\u5b83\u662f\u4e2a\u5e7f\u8c31\u7684\u6297\u75c5\u6bd2\u836f\u7269\uff0c\u53ef\u4ee5\u6297\u4e1d\u72b6\u75c5\u6bd2\u3001<strong>\u51a0\u72b6\u75c5\u6bd2<\/strong>\u548c\u526f\u7c98\u75c5\u6bd2\u3002<\/p>\n<p><strong>Remdesivir<\/strong>\u5177\u6709\u9ad8\u6548\u6d3b\u6027\uff0c\u5728\u4eba\u5de8\u566c\u7ec6\u80de\u4e2d\u6297\u57c3\u535a\u75c5\u6bd2\u7684EC<sub>50<\/sub>\u4ec5\u4e3a0.086\u00b5M\uff0c\u5728\u5185\u76ae\u7ec6\u80de\u4e2d\u4e3a0.14\u00b5M\uff0cHuh-7\u809d\u7ec6\u80de\u4e2d\u4e3a0.07\u00b5M\u3002\u5728\u6052\u6cb3\u7334\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0c\u9759\u8109\u6ce8\u5c0410mg\/Kg\u5242\u91cf\u540e\uff0c\u8840\u6d46\u534a\u8870\u671f\u4ec5\u4e3a0.39h\uff0c2h\u540e\u8fc5\u901f\u5206\u5e03\u5230\u5916\u56f4\u7ec4\u7ec7\uff0c\u5728\u5916\u56f4\u8840\u6db2\u5355\u6838\u7ec6\u80de\u4e2d\u7684\u534a\u8870\u671f\u957f\u8fbe14h\uff0c\u53ef\u4ee5\u8fbe\u52301\u65e51\u6b21\u7684\u6cbb\u7597\u3002<span style=\"color: #00ff00;\"><strong>Remdesivir<\/strong><\/span>\u5df2\u7ecf\u5904\u2162\u671f\u4e34\u5e8a\u9636\u6bb5\uff0c\u867d\u7136\u5b83\u8fd8\u6ca1\u6709\u88ab\u4e3b\u6d41\u56fd\u5bb6\u6279\u51c6\u4e0a\u5e02\uff0c\u4f46\u4e5f\u8ba9\u6211\u4eec\u770b\u5230\u4e86\u6cbb\u7597\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u7684\u5e0c\u671b\u3002<\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<ul style=\"list-style-type: disc;\">\n<li>[1] <em>Nature Communication<\/em>.<strong> 2020<\/strong>, 11, 222. DOI\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-13940-6\">10.1038\/s41467-019-13940-6<\/a><\/li>\n<li>[2] <em>J.<\/em><em> Med. Chem<\/em>. <strong>2018<\/strong>, <em>61<\/em>, 2211\u22122226. DOI\uff1a<a title=\"DOI URL\" href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.7b00734\">10.1021\/acs.jmedchem.7b00734<\/a><\/li>\n<li>[3] <em>ACS Med. Chem. Lett<\/em>.<strong> 2019<\/strong>, <em>10<\/em>, 2\u22125. DOI\uff1a<a title=\"DOI URL\" href=\"https:\/\/doi.org\/10.1021\/acsmedchemlett.8b00586\">10.1021\/acsmedchemlett.8b00586<\/a><\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u8283\u6d0b\u96ea 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Science\u5409\u5229\u5fb7\u79d1\u5b66\u7684\u4e34\u5e8a\u65b0\u836fRemdesivir\u6297\u51fb\u51a0\u72b6\u75c5\u6bd2\u6709\u6548\uff0c\u90a3\u4e48\u5b83\u53c8\u662f\u4f55\u65b9\u795e\u5723\u5462\uff1f[1] 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Nature Communication. 2020, 11, 222. DOI\uff1a10.1038\/s41467-019-13940-6 [2] J. Med. Chem. 2018, 61, 2211\u22122226. DOI\uff1a10.1021\/acs.jmedchem.7b00734 [3] ACS Med. Chem. Lett. 2019, 10, 2\u22125. 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