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{"id":30131,"date":"2020-03-02T08:00:47","date_gmt":"2020-03-02T00:00:47","guid":{"rendered":"\/\/www.gsbet888.com\/?p=30131"},"modified":"2020-07-19T13:03:50","modified_gmt":"2020-07-19T05:03:50","slug":"ojima%e5%86%85%e9%85%b0%e8%83%ba","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2020\/03\/ojima%e5%86%85%e9%85%b0%e8%83%ba.html","title":{"rendered":"Ojima\u5185\u9170\u80fa"},"content":{"rendered":"

\u6982\u8981<\/strong><\/h4>\n
1981\u5e74\u5f00\u59cb\uff0c\u65e5\u672c\u76f8\u6a21\u5316\u5b66\u7814\u7a76\u4e2d\u5fc3 (\u76f8\u6a21\u4e2d\u592e\u5316\u5b66\u7814\u7a76\u6240, Sagami Chemical Research Center)\u7684\u5c3e\u5c9b\u4e25 (\u5c3e\u5cf6 \u5dcc\uff0c<\/a>Ojima Iwao) \u7814\u7a76\u7ec4\u8fdb\u4e00\u6b65\u5c06\u4e0d\u5bf9\u79f0Staudinger\u70ef\u916e-\u4e9a\u80fa[2+2]\u73af\u52a0\u6210 (asymmetric Staudinger ketene-imine [2+2] cycloaddition)^{[1]-[4]<\/sup>\u53caStaudinger\u4e0d\u5bf9\u79f0\u916f\u70ef\u9187\u8d1f\u79bb\u5b50-\u4e9a\u80fa\u73af\u7f29\u5408 (Staudinger asymmetric ester enolate-imine cyclocondensation)^{[5]-[7]<\/sup>\u5e94\u7528\u4e8e\u5404\u79cd\u624b\u6027\u03b2-\u5185\u9170\u80fa\u7c7b\u5316\u5408\u7269\u7684\u6784\u5efa^{[1]-[7]<\/sup>\u3002<\/p>\n}}}
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\u540c\u65f6\uff0c\u8be5\u8bfe\u9898\u7ec4\u53d1\u73b0\u624b\u6027\u03b2-\u5185\u9170\u80fa\u7c7b\u5316\u5408\u7269\u5728\u5404\u7c7b\u6c28\u57fa\u9178^{[4], [8]-[12]<\/sup>\u3001\u80bd\u7c7b^{[13]-[17]<\/sup>\u3001\u975e\u86cb\u767d\u7c7b\u6c28\u57fa\u9178^{[18]-[19]<\/sup>\u3001taxoid\u6297\u80bf\u7624\u836f^{[20]-[25]<\/sup>\u3001\u542b\u6c2e\u6742\u73af^{[26]-[40]<\/sup>\u53ca\u5176\u5b83\u751f\u7269\u6d3b\u6027\u7269\u8d28\u7684\u4e0d\u5bf9\u79f0\u5408\u6210^{[41]<\/sup>\u4e2d\u5747\u53ef\u4f5c\u4e3a\u5341\u5206\u91cd\u8981\u7684\u5408\u6210\u5b50\u53ca\u5408\u6210\u780c\u5757\uff0c\u56e0\u6b64\uff0c\u6587\u732e\u4e2d\u5c06\u76f8\u5e94\u7684\u624b\u6027\u03b2-\u5185\u9170\u80fa\u79f0\u4e3aOjima\u5185\u9170\u80fa (Ojima lactam)\uff0c\u5c06\u4ee5\u624b\u6027\u03b2-\u5185\u9170\u80fa\u4e3a\u5408\u6210\u5b50\u7684\u65b9\u6cd5\u79f0\u4e3aOjima \u03b2-\u5185\u9170\u80fa\u5408\u6210\u5b50\u65b9\u6cd5 (Ojima \u03b2-lactam synthon method, \u03b2-LSM)^{[42]<\/sup>\u3002<\/p>\n}}}}}}}
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[1] H. Staudinger, Justus LiebigsAnn. Chem.<\/em>1907<\/strong>,*356<\/em>, 51. doi:**10.1002\/jlac.19073560106<\/a>.<\/li>\n*

[2] I. Ojima, H. J. C. Chen,J. Chem. Soc. Chem. Commun.<\/em>1987<\/strong>, 625. doi:10.1039\/C39870000625<\/a>.<\/li>\n

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[4] N. Hatanaka, I. Ojima,Chem. Lett. <\/em>1981<\/strong>, 234. doi:10.1246\/cl.1981.231<\/a>.<\/li>\n

[5] H. Gilman, M. Speeter,J. Am. Chem. Soc.<\/em>1943<\/strong>,*65<\/em>, 2255. doi: \u00a0**10.1021\/ja01251a503<\/a>.<\/li>\n*

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[7] I. Ojima, I. Habus,Tetrahedron Lett.<\/em>1990<\/strong>,*31<\/em>, 4289. doi:**10.1016\/S0040-4039(00)97603-2<\/a>.<\/li>\n*

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[9] I. Ojima, X. Qiu,J. Am. Chem. Soc.<\/em>1987<\/strong>,*109<\/em>, 6537. doi:**10.1021\/ja00255a063.<\/a><\/li>\n*

[10] I. Ojima, K. Nakahashi, S. M. Brandstadter, N. Hatanaka,J. Am. Chem. Soc. <\/em>1987<\/strong>,*109<\/em>, 1798. doi:**10.1021\/ja00240a033.<\/a><\/li>\n*

[11] I. Ojima, H. J. C. Chen, K. Nakahashi,J. Am. Chem. Soc<\/em>.1988<\/strong>,*110<\/em>, 278. doi:**10.1021\/ja00209a044.<\/a><\/li>\n*

[12] I. Ojima, Y. Pei,Tetrahedron Lett.<\/em>1990<\/strong>,*31<\/em>, 977. doi:**10.1016\/S0040-4039(00)94407-1.<\/a><\/li>\n*

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[14] I. Ojima, H. Wang, T. Wang, E. W. Ng,Tetrahedron Lett.<\/em>1998<\/strong>,*39<\/em>, 923. doi:**10.1016\/S0040-4039(97)10677-3<\/a>.<\/li>\n*

[15] I. Ojima, C. Sun, Y. H. Park,J. Org. Chem.<\/em>1994<\/strong>,*59<\/em>, 1249. doi:**10.1021\/jo00085a008.<\/a><\/li>\n*

[16] I. Ojima, E. W. Ng, C. Sun,Tetrahedron Lett.<\/em>1995<\/strong>,*36<\/em>, 4547. doi:**10.1016\/0040-4039(95)00825-W.<\/a><\/li>\n*

[17] I. Ojima, T. Komata, X. Qiu,J. Am. Chem. Soc<\/em>.1990<\/strong>,*112<\/em>, 770. doi:**10.1021\/ja00158a041.<\/a><\/li>\n*

[18] I. Ojima, Y. H. Park, C. Sun, M. Zhao, T. Brigaud,Tetrahedron Lett.<\/em>1992<\/strong>,*33<\/em>, 5737. doi:**10.1016\/0040-4039(92)89019-9.<\/a><\/li>\n*

[19] I. Ojima, H. J. C. Chen, X. Qiu,Tetrahedron<\/em>1988<\/strong>,*44<\/em>, 5307. doi:**10.1016\/S0040-4020(01)86038-5.<\/a><\/li>\n*

[20] I. Ojima, C. Sun, M. Zucco, Y. H. Park, O. Duclos, S. Kuduk,Tetrahedron Lett. <\/em>1993<\/strong>,*34<\/em>, 4149. doi:**10.1016\/S0040-4039(00)60514-2.<\/a><\/li>\n*

[21] I. Ojima, J. C. Slater, E. Michaud, S. D. Kuduk, P. Y. Bounaud, P. Vrignaud, M. C. Bissery, J. Veith, P. Pera, R. J. Bernacki,J. Med. Chem.<\/em>1996<\/strong>,*39<\/em>, 3889. doi:**10.1021\/jm9604080.<\/a><\/li>\n*

[22] I. Ojima, S. D. Kuduk, J. C. Slater, R. H. Gimi, C. M. Sun,Tetrahedron,<\/em>1996<\/strong>,*52<\/em>, 209. doi:**10.1016\/0040-4020(95)00865-6.<\/a><\/li>\n*

[23] I. Ojima, J. C. Slater, P. Pera, J. M. Veith, A. Abouabdellah, J. P. Begue, R. J. Bernacki,Bioorg. Med. Chem. Lett<\/em>.1997<\/strong>,*7<\/em>, 133. doi:**10.1016\/S0960-894X(96)00595-1.<\/a><\/li>\n*

[24] I. Ojima, I. Habus, M. Zhao, G. I. Georg, L. R. Jayashinge,J. Org. Chem.<\/em>1991<\/strong>,*56<\/em>, 1681. doi:**10.1021\/jo00005a003.<\/a><\/li>\n*

[25] I. Ojima, J. C. Slater, S. D. Kuduk, C. S. Takeuchi, R. H. Gimi, C. Sun, Y. H. Park, P. Pera, J. M. Veith, R. J. Bernacki,J. Med. Chem.<\/em>1997<\/strong>,*40<\/em>, 267. doi:**10.1021\/jm960563e.<\/a><\/li>\n*

[26] K. Anushree I. Ojima,Tetrahedron<\/em>2012<\/strong>,*68<\/em>, 10640. doi:**10.1016\/j.tet.2012.07.090<\/a>.<\/li>\n*

[27] B. Alcaide, Y. Martin-Cantalejo, J. Rodriguez-Lopez, M. Sierra,J. Org. Chem<\/em>.\u00a01993<\/strong>,*58<\/em>, 4767. doi:**10.1021\/jo00069a054<\/a>.<\/li>\n*

[28] B. Alcaide, P. Almendros, G. Cabrero, M. Ruiz,Org. Lett<\/em>.2005<\/strong>,*7<\/em>, 3981. doi:**10.1021\/ol051504a<\/a>.<\/li>\n*

[29] L. A. Cabell, J. S. McMurray,Tetrahedron Lett. <\/em>2002<\/strong>,*43<\/em>, 2491. doi:**10.1016\/S0040-4039(02)00318-0<\/a>.<\/li>\n*

[30] M. Alajarin, P. Sanchez-Andrada,J. Org. Chem<\/em>.2001<\/strong>,*66<\/em>, 8470. doi:**10.1021\/jo015922e<\/a>.<\/li>\n*

[31] M. Alajarin, A. Vidal, P. Sanchez-Andrada, F. Tovar, G. Ochoa,*Org. Lett<\/em>.2000<\/strong>,\u00a02<\/em>, 965. doi:**10.1021\/ol0056168<\/a>.<\/li>\n*

[32] P. Almendros, C. Aragoncillo, G. Cabrero, R. Callejo, R. Carrascosa, A. Luna, del T. M. Campo, M. C. Pardo, M. T. Quiros, M. C. Redondo, C. Rodriguez-Ranera, A. Rodriguez-Vicente, M. P. Ruiz,Arkivoc<\/em>2010<\/strong>, 74. doi:10.3998\/ark.5550190.0011.308<\/a>.<\/li>\n

[33] M. D’hooghe, S. Dekeukeleire, E. Leemans, N. De Kimpe,Pure Appl.\u00a0<\/em>Chem<\/em>.2010<\/strong>,*82<\/em>, 1749. doi:**10.1351\/PAC-CON-09-09-39<\/a>.<\/li>\n*

[34] N. Piens, S. De Craene, J. Franceus, K. Mollet, K. Van Hecke, T. Desmet, M. D’ hooghe,Org. Biomol. Chem<\/em>.2016<\/strong>,*14<\/em>, 11279. doi:**10.1039\/C6OB02221A<\/a>.<\/li>\n*

[35] A. Mac\u00edas, E. Alonso, C. Del Pozo, J. Gonz_lez,Tetrahedron Lett<\/em>.2004<\/strong>,*45<\/em>, 4657. doi:**10.1016\/j.tetlet.2004.04.109<\/a><\/li>\n*

[36] A. Vasudevan, C. I. Villamil, S. W. Djuric,Org. Lett.<\/em>2004<\/strong>,*6<\/em>, 3361. doi:**10.1021\/ol048638t.<\/a><\/li>\n*

[37] B. Alcaide, P. Almendros, G. Cabrero, M. P. Ruiz,Chem. Commun<\/em>.2007<\/strong>, 4788. doi:10.1039\/B711473G<\/a>.<\/li>\n

[38] P. Singh, P. Singh, K. Kumar, V. Kumar, M. P. Mahajan, K. Bisetty,Heterocycles<\/em>2012<\/strong>,*86<\/em>, 1301. doi:**10.3987\/COM-12-S(N)83<\/a>.<\/li>\n*

[39] V. Mehra, P. Singh, N. Manhas, V. Kumar,Synlettt\u00a0<\/em>2014<\/strong>,*25<\/em>, 1124. doi:**10.1055\/s-0033-1341049<\/a>.<\/li>\n*

[40] K. Kumar, S. Kumar, T. Singh, A. Anand, V. Kumar,Tetrahedron Lett<\/em>.2014<\/strong>,*55<\/em>, 3957. doi:**10.1016\/j.tetlet.2014.05.016<\/a>.<\/li>\n*

[41] I. Ojima, M. Zhao, T. Yamato, K. Nakahashi, M. Yamashita, R. Abe,J. Org. Chem.<\/em>1991,<\/strong>*56<\/em>, 5263. doi:**10.1021\/jo00018a012.<\/a><\/li>\n*

[42] I. Ojima,Acc. Chem. Res. <\/em>1995<\/strong>,28<\/em>, 383. doi:10.1021\/ar00057a004.<\/a><\/li>\n<\/ul>\n
\u53cd\u5e94\u673a\u7406<\/strong><\/h4>\n<\/a><\/p>\n
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\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n
\n
[1] F. P. Coss\u00edo, A. Arrieta, M. A. Sierra,Acc. Chem. Res.<\/em>2008<\/strong>,*41<\/em>, 925. doi:**10.1021\/ar800033j<\/a>.<\/li>\n*

[2] F. P. Coss\u00edo, J. M. Ugalde, X. Lopez, B. Lecea, C. Palomo,J. Am. Chem. Soc.<\/em>1993<\/strong>,*115<\/em>, 995. doi:**10.1021\/ja00056a026.<\/a><\/li>\n*

[3] S. Dumas, L. S. Hegedus,J. Org. Chem<\/em>.1994<\/strong>,*59<\/em>, 4967. doi:**10.1021\/jo00096a046.<\/a><\/li>\n*

[4] E. Mart\u00edn-Zamora, A. Ferrete, J. M. Llera, J. M. Mun\u00f5z, R. R. Pappalardo, R. Fern\u00e1ndez, J. M. Lassaletta,Chem. Eur. J<\/em>.2004<\/strong>,*10<\/em>, 6111. doi:**10.1002\/chem.200400452<\/a>.<\/li>\n*

[5] F. P. Coss\u00edo, A. Arrieta, B. Lecea, J. M. Ugalde,J. Am. Chem. Soc<\/em>.1994<\/strong>,*116<\/em>, 2085. doi:**10.1021\/ja00084a054<\/a>.<\/li>\n*

[6] I. Ojima, Habus, M. Zhao, M. Zucco, Y. Park, C. Sun, T. Brigaud,Tetrahedron<\/em>,1992<\/strong>,48<\/em>, 6985. doi:10.1016\/S0040-4020(01)91210-4. <\/a><\/li>\n<\/ul>\n
\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/h4>\n
\u6c28\u57fa\u9178\u53ca\u5176\u884d\u751f\u7269\u7684\u5408\u6210^{[1]<\/sup><\/p>\n}
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\u6742\u73af\u5316\u5408\u7269\u7684\u5408\u6210^{[2]<\/sup><\/p>\n}
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\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/h4>\n
\u70ef\u916e-\u4e9a\u80fa<\/strong>[2+2]<\/strong>\u73af\u52a0\u6210<\/strong><\/p>\n
\u5411\u5706\u5e95\u70e7\u74f6\u4e2d\u52a0\u5165\u4e9a\u80fa (1 eq.)\uff0c\u4e4b\u540e\u52a0\u5165\u65e0\u6c34THF\u6eb6\u89e3 (\u7ef4\u6301\u5e95\u7269\u6d53\u5ea6\u4e3a0.4 M)\uff0c\u968f\u540e\uff0c\u52a0\u5165\u4e09\u4e59\u80fa (3 eq.)\u3002\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u51b7\u5374\u81f30 \u00b0C\uff0c\u968f\u540e\u6ef4\u52a0\u9170\u6c2f\u7684\u65e0\u6c34THF\u6eb6\u6db2 (1.5eq., \u9170\u6c2f\u6d53\u5ea6\u4e3a2.5 M)\u3002\u6ef4\u52a0\u7ed3\u675f\u540e\uff0c\u5347\u81f3\u5ba4\u6e29\uff0c\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\u8fdb\u884c\u6405\u62cc\uff0c\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u3002\u5c06\u6b8b\u4f59\u7269\u901a\u8fc7\u4e8c\u6c2f\u7532\u70f7\u6eb6\u89e3\uff0c\u52a0\u5165\u6c34\u8fdb\u884c\u6d17\u6da4\uff0c\u540c\u65f6\uff0c\u7ee7\u7eed\u52a0\u5165\u4e8c\u6c2f\u7532\u70f7\u8fdb\u884c\u8403\u53d6\u3002\u5408\u5e76\u6709\u673a\u76f8\uff0c\u91c7\u7528\u65e0\u6c34\u786b\u9178\u9541\u8fdb\u884c\u5e72\u71e5\u3002\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u540e\uff0c\u5c06\u7c97\u4ea7\u7269\u901a\u8fc7\u5feb\u901f\u67f1\u8272\u8c31 (\u77f3\u6cb9\u919a\/\u4e59\u9178\u4e59\u916f 2:1 v\/v \u4f5c\u4e3a\u6d17\u8131\u5242)\u5206\u79bb\u7eaf\u5316\u83b7\u5f97\u76f8\u5e94\u03b2-\u5185\u9170\u80fa\u4ea7\u7269\u3002<\/p>\n
\u70ef\u9187\u8d1f\u79bb\u5b50-\u4e9a\u80fa\u73af\u7f29\u5408<\/strong><\/p>\n
0 \u00b0C\u4e0b\uff0c\u5411\u4e8c\u5f02\u4e19\u80fa\u7684\u65e0\u6c34THF\u6eb6\u6db2 (\u6d53\u5ea6\u4e3a0.05 M)\u4e2d\u52a0\u5165\u6b63\u4e01\u57fa\u9502 (2.5 M\u6b63\u5df1\u70f7\u6eb6\u6db2\uff0c\u4e0e\u4e8c\u5f02\u4e19\u80fa\u8ba1\u91cf\u6bd4\u4e3a1:1)\u3002\u7ef4\u63010 \u00b0C\uff0c\u5c06\u4e0a\u8ff0\u5747\u76f8\u6df7\u5408\u7269\u6405\u62cc1 h\uff0c\u4e4b\u540e\u51b7\u5374\u81f3-78 \u00b0C\u3002\u901a\u8fc7\u63d2\u7ba1\u5c06\u916f\u5e95\u7269\u7684\u65e0\u6c34THF\u6eb6\u6db2 (1 eq., \u5e95\u7269\u6d53\u5ea6\u4e3a0.04 M)\u6ef4\u52a0\u81f3\u4e0a\u8ff0\u539f\u4f4d\u751f\u6210\u7684LDA (1.2 eq.)\u4e2d\uff0c\u8d85\u8fc72 h\u540e\uff0c\u6ef4\u52a0\u5b8c\u6bd5\u3002\u968f\u540e\uff0c\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u51b7\u5374\u81f3-85 \u00b0C\uff0c\u518d\u5c06\u4e9a\u80fa\u7684\u65e0\u6c34THF\u6eb6\u6db2 (1.3 eq., \u5e95\u7269\u6d53\u5ea6\u4e3a0.05 M)\u6ef4\u52a0\u81f3\u4e0a\u8ff0\u53cd\u5e94\u4f53\u7cfb\u4e2d\uff0c\u8d85\u8fc73 h\u540e\uff0c\u6ef4\u52a0\u5b8c\u6bd5\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u5347\u81f3\u5ba4\u6e29\uff0c\u6405\u62cc\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u52a0\u5165\u9971\u548c\u6c2f\u5316\u94f5\u6eb6\u6db2\u8fdb\u884c\u6dec\u706d\uff0c\u6dec\u706d\u5b8c\u6210\u540e\uff0c\u52a0\u5165\u4e59\u919a\u8fdb\u884c\u8403\u53d6\uff0c\u5c06\u5408\u5e76\u7684\u6709\u673a\u76f8\u91c7\u7528\u65e0\u6c34\u786b\u9178\u9541\u8fdb\u884c\u5e72\u71e5\uff0c\u968f\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u3002\u5c06\u7c97\u4ea7\u7269\u901a\u8fc7\u7845\u80f6\u67f1\u8272\u8c31 (\u6b63\u5df1\u70f7\/\u4e59\u9178\u4e59\u916f 5:1 v\/v \u4f5c\u4e3a\u6d17\u8131\u5242)\u5206\u79bb\u7eaf\u5316\u83b7\u5f97\u76f8\u5e94\u03b2-\u5185\u9170\u80fa\u4ea7\u7269\u3002<\/p>\n
\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n \n
[1] I. Ojima,Acc. Chem. Res.<\/em>1995<\/strong>,*28<\/em>, 383. doi:**10.1021\/ar00057a004.<\/a><\/li>\n*

[2] P. Sharma, M. J. K. Mann, B. Kuila, P. Singh, G. Bhargava,Synlett <\/em>2016<\/strong>,*27<\/em>, 422. doi:**10.1055\/s-0035-1560826.<\/a><\/li>\n*

[3] I. Ojima, M. Zhao, T. Yamato, K. Nakahashi, M. Yamashita, R. Abe,J. Org. Chem<\/em>1991<\/strong>,56<\/em>, 5263. doi:10.1021\/jo00018a012.<\/a><\/li>\n<\/ul>\n
\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 1981\u5e74\u5f00\u59cb\uff0c\u65e5\u672c\u76f8\u6a21\u5316\u5b66\u7814\u7a76\u4e2d\u5fc3 (\u76f8\u6a21\u4e2d\u592e\u5316\u5b66\u7814\u7a76\u6240, Sagami Chemical Research Center)\u7684\u5c3e\u5c9b\u4e25 (\u5c3e\u5cf6 \u5dcc\uff0cOjima Iwao) \u7814\u7a76\u7ec4\u8fdb\u4e00\u6b65\u5c06\u4e0d\u5bf9\u79f0Staudinger\u70ef\u916e-\u4e9a\u80fa[2+2]\u73af\u52a0\u6210 (asymmetric Staudinger ketene-imine [2+2] cycloaddition) [1]-[4]\u53caStaudinger\u4e0d\u5bf9\u79f0\u916f\u70ef\u9187\u8d1f\u79bb\u5b50-\u4e9a\u80fa\u73af\u7f29\u5408 (Staudinger asymmetric ester enolate-imine cyclocondensation) [5]-[7]\u5e94\u7528\u4e8e\u5404\u79cd\u624b\u6027\u03b2-\u5185\u9170\u80fa\u7c7b\u5316\u5408\u7269\u7684\u6784\u5efa[1]-[7]\u3002 \u540c\u65f6\uff0c\u8be5\u8bfe\u9898\u7ec4\u53d1\u73b0\u624b\u6027\u03b2-\u5185\u9170\u80fa\u7c7b\u5316\u5408\u7269\u5728\u5404\u7c7b\u6c28\u57fa\u9178[4], [8]-[12]\u3001\u80bd\u7c7b[13]-[17]\u3001\u975e\u86cb\u767d\u7c7b\u6c28\u57fa\u9178[18]-[19]\u3001taxoid\u6297\u80bf\u7624\u836f[20]-[25]\u3001\u542b\u6c2e\u6742\u73af[26]-[40]\u53ca\u5176\u5b83\u751f\u7269\u6d3b\u6027\u7269\u8d28\u7684\u4e0d\u5bf9\u79f0\u5408\u6210[41]\u4e2d\u5747\u53ef\u4f5c\u4e3a\u5341\u5206\u91cd\u8981\u7684\u5408\u6210\u5b50\u53ca\u5408\u6210\u780c\u5757\uff0c\u56e0\u6b64\uff0c\u6587\u732e\u4e2d\u5c06\u76f8\u5e94\u7684\u624b\u6027\u03b2-\u5185\u9170\u80fa\u79f0\u4e3aOjima\u5185\u9170\u80fa (Ojima lactam)\uff0c\u5c06\u4ee5\u624b\u6027\u03b2-\u5185\u9170\u80fa\u4e3a\u5408\u6210\u5b50\u7684\u65b9\u6cd5\u79f0\u4e3aOjima \u03b2-\u5185\u9170\u80fa\u5408\u6210\u5b50\u65b9\u6cd5 (Ojima \u03b2-lactam synthon method, \u03b2-LSM) [42]\u3002 \u57fa\u672c\u6587\u732e [1] H. Staudinger, Justus Liebigs Ann. Chem. 1907, 356, 51. doi: 10.1002\/jlac.19073560106. [2] I. Ojima, H. J. C. Chen, J. Chem. Soc. Chem. Commun. 1987, 625. doi: 10.1039\/C39870000625. [3] A. K. Bose, M. S. Manhas, J. C. Chib, H. P. S. Chawla, B. Dayal, J. Org. Chem. 1974, 39, 2877. doi: 10.1021\/jo00933a013. [4] N. Hatanaka, I. Ojima, Chem. Lett. 1981, 234. doi: 10.1246\/cl.1981.231. [5] H. Gilman, M. Speeter, J. Am. Chem. Soc. 1943, 65, 2255. […]","protected":false},"author":21,"featured_media":30141,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/6b61fe61585388f1b6b517dd7310a73e.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-7PZ","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/30131"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=30131"}],"version-history":[{"count":6,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/30131\/revisions"}],"predecessor-version":[{"id":33964,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/30131\/revisions\/33964"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/30141"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=30131"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=30131"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=30131"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

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