{"id":30144,"date":"2020-02-25T08:00:50","date_gmt":"2020-02-25T00:00:50","guid":{"rendered":"\/\/www.gsbet888.com\/?p=30144"},"modified":"2020-07-19T13:03:02","modified_gmt":"2020-07-19T05:03:02","slug":"inanaga-%e5%90%b2%e5%93%9a%e5%90%88%e6%88%90","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2020\/02\/inanaga-%e5%90%b2%e5%93%9a%e5%90%88%e6%88%90.html","title":{"rendered":"Inanaga \u5432\u54da\u5408\u6210"},"content":{"rendered":"<h4><strong>\u6982\u8981<\/strong><\/h4>\n<p>Inanaga\u5432\u54da\u5408\u6210 (Inanaga Indole Synthesis)\u662f\u901a\u8fc7\u4e8c\u7898\u5316\u9490\u4e0e\u90bb\u4f4d\u8fde\u6709N-\u53d6\u4ee3\u7094\u57fa\u6216N-\u53d6\u4ee3\u70ef\u57fa\u7684\u82b3\u57fa\u6eb4\u4e4b\u95f4\u7684\u81ea\u7531\u57fa\u73af\u5316\u8fc7\u7a0b\uff0c\u5408\u6210\u5432\u54da\u53ca\u4e8c\u6c22\u5432\u54da\u7c7b\u5316\u5408\u7269\u7684\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u7531\u65e5\u672c\u4e5d\u5dde\u5927\u5b66\u5316\u5b66\u7cfb (\u4e5d\u5dde\u5927\u5b66\u7406\u5b66\u90e8\u5316\u5b66\u6559\u5ba4, Department of Chemistry, Kyushu University)\u7684\u7a3b\u6c38\u7eaf\u4e8c (\u7a32\u6c38 \u7d14\u4e8c, Inanaga Junji)\u7814\u7a76\u7ec4\u57281991\u5e74\u9996\u6b21\u62a5\u9053\u3002\u8be5\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\uff0c\u4ea7\u7387\u4f18\u826f\u3002\u540c\u65f6\uff0cInanaga\u7814\u7a76\u53d1\u73b0\u901a\u8fc7\u4e8c\u7898\u5316\u9490\u4e0e\u90bb\u4f4d\u8fde\u6709O-\u53d6\u4ee3\u7094\u57fa\u7684\u82b3\u57fa\u6eb4\u540c\u6837\u53ef\u4ee5\u5b8c\u6210\u82ef\u5e76\u544b\u5583\u53ca\u8418\u5e76\u544b\u5583\u9aa8\u67b6\u7684\u6784\u5efa\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/aa3023e0288002c8592c3c8fc4194d66.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-33960 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/aa3023e0288002c8592c3c8fc4194d66.png\" alt=\"\" width=\"860\" height=\"299\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/aa3023e0288002c8592c3c8fc4194d66.png 860w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/aa3023e0288002c8592c3c8fc4194d66-300x104.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/aa3023e0288002c8592c3c8fc4194d66-680x236.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/aa3023e0288002c8592c3c8fc4194d66-768x267.png 768w\" sizes=\"(max-width: 860px) 100vw, 860px\" \/><\/a><strong>\u57fa\u672c\u6587\u732e<\/strong><\/p>\n<ul style=\"list-style-type: circle\">\n<li>[1] J. Inanaga, O. Ujikawa, M. Yamaguchi, <em>Tetrahedron Lett.<\/em> <strong>1991<\/strong>, <em>32<\/em>, 1737. doi: <a href=\"https:\/\/doi.org\/10.1016\/S0040-4039(00)74317-6\">10.1016\/S0040-4039(00)74317-6<\/a>.<\/li>\n<li>[2] G. A. Molander, C. R. Harris, <em>Chem. Rev.<\/em> <strong>1996<\/strong>, <em>96<\/em>, 307. <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/cr950019y\">10.1021\/cr950019y<\/a>.<\/li>\n<\/ul>\n<h4><strong>\u53cd\u5e94\u673a\u7406<\/strong><\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/2-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30146 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/2-1.png\" alt=\"\" width=\"825\" height=\"353\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/2-1.png 1379w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/2-1-300x128.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/2-1-768x328.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/2-1-680x290.png 680w\" sizes=\"(max-width: 825px) 100vw, 825px\" \/><\/a><\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul style=\"list-style-type: circle\">\n<li>[1] E. Hasegawa, D. P. Curran, <em>J. Org. Chem.<\/em> <strong>1993<\/strong>, <em>58<\/em>, 5008. doi: <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jo00070a046\">10.1021\/jo00070a046.<\/a><\/li>\n<\/ul>\n<h4><strong>\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/h4>\n<p>\u5432\u54da\u7c7b\u5316\u5408\u7269\u7684\u5408\u6210[1]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/3-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30147 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/3-1.png\" alt=\"\" width=\"763\" height=\"242\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/3-1.png 867w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/3-1-300x95.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/3-1-768x244.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/3-1-680x216.png 680w\" sizes=\"(max-width: 763px) 100vw, 763px\" \/><\/a><\/p>\n<p>\u8418\u5e76\u5421\u5583\u7c7b\u5316\u5408\u7269\u7684\u5408\u6210[1]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/a.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30153 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/a.png\" alt=\"\" width=\"754\" height=\"232\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/a.png 911w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/a-300x92.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/a-768x236.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/a-680x209.png 680w\" sizes=\"(max-width: 754px) 100vw, 754px\" \/><\/a><\/p>\n<p>\u4e8c\u6c22\u5432\u54da\u7c7b\u5316\u5408\u7269\u7684\u5408\u6210[1]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/a.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30153 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/a.png\" alt=\"\" width=\"754\" height=\"232\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/a.png 911w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/a-300x92.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/a-768x236.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/a-680x209.png 680w\" sizes=\"(max-width: 754px) 100vw, 754px\" \/><\/a><\/p>\n<h4><strong>\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/h4>\n<p>\u5728\u5ba4\u6e29\u6c2e\u6c14\u6c14\u6c1b\u4e0b\uff0c\u5c06\u82b3\u57fa\u6eb4\u5e95\u7269 (1 eq.)\u6eb6\u4e8e\u65e0\u6c34THF (\u7ef4\u6301\u5e95\u7269\u6d53\u5ea6\u4e3a0.4 M)\uff0c\u4e4b\u540e\u52a0\u5165\u4e8c\u7898\u5316\u9490 (0.1 M THF\u6eb6\u6db2, 3 eq. )\u53ca\u9002\u91cfHMPA\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\u6405\u62cc\uff0c\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u52a0\u5165\u9971\u548c\u6c2f\u5316\u94f5\u6eb6\u6db2\u8fdb\u884c\u6dec\u706d\u3002\u6dec\u706d\u5b8c\u6210\u540e\uff0c\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u52a0\u5165\u4e59\u9178\u4e59\u916f\u8fdb\u884c\u8403\u53d6\uff0c\u5408\u5e76\u6709\u673a\u76f8\uff0c\u91c7\u7528\u65e0\u6c34\u786b\u9178\u94a0\u5e72\u71e5\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u3002\u5c06\u7c97\u4ea7\u7269\u91c7\u7528\u7845\u80f6\u67f1\u8272\u8c31\u5206\u79bb\u7eaf\u5316\u540e\uff0c\u83b7\u5f97\u76f8\u5e94\u76ee\u6807\u4ea7\u7269\u3002<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul style=\"list-style-type: circle\">\n<li>[1] J. Inanaga, O. Ujikawa, M. Yamaguchi, <em>Tetrahedron Lett.<\/em> <strong>1991<\/strong>, <em>32<\/em>, 1737. doi: <a href=\"https:\/\/doi.org\/10.1016\/S0040-4039(00)74317-6\">10.1016\/S0040-4039(00)74317-6<\/a>.<\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 Inanaga\u5432\u54da\u5408\u6210 (Inanaga Indole Synthesis)\u662f\u901a\u8fc7\u4e8c\u7898\u5316\u9490\u4e0e\u90bb\u4f4d\u8fde\u6709N-\u53d6\u4ee3\u7094\u57fa\u6216N-\u53d6\u4ee3\u70ef\u57fa\u7684\u82b3\u57fa\u6eb4\u4e4b\u95f4\u7684\u81ea\u7531\u57fa\u73af\u5316\u8fc7\u7a0b\uff0c\u5408\u6210\u5432\u54da\u53ca\u4e8c\u6c22\u5432\u54da\u7c7b\u5316\u5408\u7269\u7684\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u7531\u65e5\u672c\u4e5d\u5dde\u5927\u5b66\u5316\u5b66\u7cfb (\u4e5d\u5dde\u5927\u5b66\u7406\u5b66\u90e8\u5316\u5b66\u6559\u5ba4, Department of Chemistry, Kyushu University)\u7684\u7a3b\u6c38\u7eaf\u4e8c (\u7a32\u6c38 \u7d14\u4e8c, Inanaga Junji)\u7814\u7a76\u7ec4\u57281991\u5e74\u9996\u6b21\u62a5\u9053\u3002\u8be5\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\uff0c\u4ea7\u7387\u4f18\u826f\u3002\u540c\u65f6\uff0cInanaga\u7814\u7a76\u53d1\u73b0\u901a\u8fc7\u4e8c\u7898\u5316\u9490\u4e0e\u90bb\u4f4d\u8fde\u6709O-\u53d6\u4ee3\u7094\u57fa\u7684\u82b3\u57fa\u6eb4\u540c\u6837\u53ef\u4ee5\u5b8c\u6210\u82ef\u5e76\u544b\u5583\u53ca\u8418\u5e76\u544b\u5583\u9aa8\u67b6\u7684\u6784\u5efa\u3002 \u57fa\u672c\u6587\u732e [1] J. Inanaga, O. Ujikawa, M. Yamaguchi, Tetrahedron Lett. 1991, 32, 1737. doi: 10.1016\/S0040-4039(00)74317-6. [2] G. A. Molander, C. R. Harris, Chem. Rev. 1996, 96, 307. 10.1021\/cr950019y. \u53cd\u5e94\u673a\u7406 \u53c2\u8003\u6587\u732e [1] E. Hasegawa, D. P. Curran, J. Org. Chem. 1993, 58, 5008. doi: 10.1021\/jo00070a046. \u53cd\u5e94\u5b9e\u4f8b \u5432\u54da\u7c7b\u5316\u5408\u7269\u7684\u5408\u6210[1] \u8418\u5e76\u5421\u5583\u7c7b\u5316\u5408\u7269\u7684\u5408\u6210[1] \u4e8c\u6c22\u5432\u54da\u7c7b\u5316\u5408\u7269\u7684\u5408\u6210[1] \u5b9e\u9a8c\u6b65\u9aa4 \u5728\u5ba4\u6e29\u6c2e\u6c14\u6c14\u6c1b\u4e0b\uff0c\u5c06\u82b3\u57fa\u6eb4\u5e95\u7269 (1 eq.)\u6eb6\u4e8e\u65e0\u6c34THF (\u7ef4\u6301\u5e95\u7269\u6d53\u5ea6\u4e3a0.4 M)\uff0c\u4e4b\u540e\u52a0\u5165\u4e8c\u7898\u5316\u9490 (0.1 M THF\u6eb6\u6db2, 3 eq. )\u53ca\u9002\u91cfHMPA\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\u6405\u62cc\uff0c\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u52a0\u5165\u9971\u548c\u6c2f\u5316\u94f5\u6eb6\u6db2\u8fdb\u884c\u6dec\u706d\u3002\u6dec\u706d\u5b8c\u6210\u540e\uff0c\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u52a0\u5165\u4e59\u9178\u4e59\u916f\u8fdb\u884c\u8403\u53d6\uff0c\u5408\u5e76\u6709\u673a\u76f8\uff0c\u91c7\u7528\u65e0\u6c34\u786b\u9178\u94a0\u5e72\u71e5\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u3002\u5c06\u7c97\u4ea7\u7269\u91c7\u7528\u7845\u80f6\u67f1\u8272\u8c31\u5206\u79bb\u7eaf\u5316\u540e\uff0c\u83b7\u5f97\u76f8\u5e94\u76ee\u6807\u4ea7\u7269\u3002 \u53c2\u8003\u6587\u732e [1] J. Inanaga, O. Ujikawa, M. Yamaguchi, Tetrahedron Lett. 1991, 32, 1737. doi: 10.1016\/S0040-4039(00)74317-6. \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01","protected":false},"author":21,"featured_media":30150,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/02\/fe68bba98035763820d46e346c706c4e.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-7Qc","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/30144"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=30144"}],"version-history":[{"count":6,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/30144\/revisions"}],"predecessor-version":[{"id":33963,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/30144\/revisions\/33963"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/30150"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=30144"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=30144"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=30144"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}