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\/><\/a><\/p>\n<p>\u8fd9\u662f\u4e00\u4e2a\u7ecf\u5386Staudinger\/\u6c2e\u6742Wittig\u53cd\u5e94\u4e4b\u540e\u5b9e\u73b0\u5927\u73af\u5185\u9170\u80fa\u5316\u7684\u8fc7\u7a0b<\/p>\n<h4><strong>REFERENCES<\/strong><\/h4>\n<ul style=\"list-style-type: circle;\">\n<li>[1]<em> Tetrahedron Lett.<\/em>, <strong>1990<\/strong>, <em>31<\/em>, 205, DOI: <a href=\"https:\/\/doi.org\/10.1016\/S0040-4039(00)94371-5\">1016\/S0040-4039(00)94371-5<\/a><\/li>\n<li>[2]<em> Synthesis <\/em><strong>1984<\/strong>, <em>7<\/em>, 572-574. DOI: 10.1055\/s-1984-30895<\/li>\n<li>[3]<em> J. Am. Chem. Soc<\/em>.<strong> 1999<\/strong>, <em>12<\/em>, 127, 6355-6366<a href=\"https:\/\/doi.org\/10.1021\/ja9811243\">, DOI: 10.1021\/ja9811243<\/a><\/li>\n<li>[4]<em> J. Am. Chem. Soc. <\/em><strong>1999<\/strong>, <em>12<\/em>, 126, 6197-6205<a href=\"https:\/\/doi.org\/10.1021\/ja990918u\">, DOI: 10.1021\/ja990918u<\/a><\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u5b59\u82cf\u8d5f \u7b2c\u56db\u90e8\u5206 \u76f4\u63a5\u6cd5\u9170\u80fa\u5316 \u5728\u916f\u7684\u5408\u6210\u4e2d\uff0c\u4f1a\u4f7f\u7528DCC\u7c7b\u8bd5\u5242\u6d3b\u5316\u53cd\u5e94\u5e95\u7269\uff0c\u56e0\u4e3a\u53cd\u5e94\u6e29\u548c\u4e14\u9ad8\u6548\uff0c\u56e0\u6b64\u53d7\u5230\u542f\u53d1\u5c06\u6b64\u7c7b\u8bd5\u5242\u7528\u4e8e\u80bd\u7684\u5408\u6210\u4e2d\u53bb\uff0c\u4f46\u662f\u5728\u53cd\u5e94\u4e2d\u4e0d\u540c\u7684\u662f\u9700\u8981\u4f7f\u7528\u5230\u5076\u8054\u8bd5\u5242\u6765\u6d3b\u5316\u7fa7\u57fa\u3002\u4f46\u662f\u8fd9\u7c7b\u53cd\u5e94\u7684\u4e00\u4e2a\u5c40\u9650\u662f\u53cd\u5e94\u4e2d\u53ef\u80fd\u4f1a\u5b58\u5728\u5f02\u6784\u5316\u8fc7\u7a0b\uff0c\u8fd9\u662f\u4e00\u4e2a\u9700\u8981\u6ce8\u610f\u7684\u95ee\u9898\u3002 \u78b3\u4e8c\u4e9a\u80fa\u7c7b\u8bd5\u5242\u4f5c\u7528\u4e0b\u7684\u53cd\u5e94 \u5728\u80bd\u7684\u5408\u6210\u4e2d\uff0c\u76f8\u6bd4\u4e8e\u5355\u72ec\u4f7f\u7528\u78b3\u4e8c\u4e9a\u80fa\u7c7b\u8bd5\u5242\uff0cHOBt\u548c\u78b3\u4e8c\u4e9a\u80fa\u7c7b\u8bd5\u5242\u7684\u7ec4\u5408\u662f\u975e\u5e38\u9ad8\u6548\u4e14\u5e38\u7528\u7684\u3002DCC\u548c\u7fa7\u9178\u53d1\u751f\u9178\u78b1\u53cd\u5e94\u751f\u6210O-acylisouera\u4e2d\u95f4\u4f53\u53ef\u80fd\u4f1a\u53d1\u751f\u91cd\u62cd\u6216\u5176\u4ed6\u526f\u53cd\u5e94\u3002\u6b64\u5916\u8fd8\u53ef\u80fd\u4f1a\u751f\u6210\u6076\u5511\u916e\u884d\u751f\u7269\uff1a \u53cd\u5e94\u8fc7\u7a0b\u5927\u81f4\u5982\u4e0b\uff1a 2. \u5076\u8054\u8bd5\u5242 BOP\u8bd5\u5242\u548c\u5176\u4ed6\u7c7b\u4f3c\u8bd5\u5242\u7684\u5076\u8054\u8bd5\u5242\u662f\u4e00\u79cd\u95f4\u63a5\u7684\u539f\u4f4d\u4ea7\u751fHOBt\u7684\u65b9\u6cd5\u3002\u6b64\u5916PyBOP\u548cHMPA\u7684\u7ec4\u5408\u4e5f\u53ef\u4ee5\u66ff\u4ee3BOP\uff0c\u4f46\u662f\u5b83\u7684\u6bd2\u6027\u4f1a\u6bd4\u540e\u8005\u5c0f\u3002\u5728\u8fd9\u4e9b\u5076\u8054\u8bd5\u5242\u7684\u4f5c\u7528\u4e0b\uff0c\u9700\u8981\u78b1\u6765\u751f\u6210\u7fa7\u9178\u79bb\u5b50\uff0c\u5e38\u7528\u7684\u662f\u53d4\u80fa\u7c7b\u8bd5\u5242\u3002\u53cd\u5e94\u7684\u8fc7\u7a0b\u4e2d\u4f1a\u4ea7\u751facyloxyphosphonium\u4e2d\u95f4\u4f53\uff0c\u540c\u65f6\u53cd\u5e94\u4e2d\u9700\u8981\u6dfb\u52a0\u7a0d\u8fc7\u91cf\u7684HOBt\u3002 \u53e6\u5916\u8fd8\u6709\u5176\u4ed6\u7684\u4e00\u4e9b\u5076\u8054\u8bd5\u5242\uff1a[1-2] \u51fa\u4e86\u4e0a\u8ff0\u4e09\u79cd\u5076\u8054\u8bd5\u5242\uff0c\u8fd8\u6709\u4ee5\u4e0b\u4e09\u79cd\u5076\u8054\u8bd5\u5242\uff0c\u5b83\u4eec\u7684\u4ef7\u683c\u66f4\u52a0\u6602\u8d35\uff0c\u4f46\u662f\u6548\u679c\u4e5f\u975e\u5e38\u51fa\u4f17\u3002\u5b83\u4eec\u53ef\u4ee5\u5f88\u5bb9\u6613\u7684\u548c\u5927\u4f4d\u963b\u7684\u9178\u548c\u4e8c\u7ea7\u80fa\uff0c\u751a\u81f3\u4e09\u7ea7\u80fa\u53d1\u751f\u53cd\u5e94\u3002 HOAT\u7c7b\u8bd5\u5242\u4e2d\u7684\u6742\u73af\u4e0a\u7684\u6c2e\u539f\u5b50\u53ef\u4ee5\u4f5c\u4e3a\u78b1\u53c2\u4e0e\u5230\u53cd\u5e94\u4e2d\uff0c\u56e0\u6b64\u8fd9\u7c7b\u5076\u8054\u8bd5\u5242\u7684\u53cd\u5e94\u673a\u7406\u5982\u4e0b\uff1a a. \u5408\u6210\u591a\u80bd[3] \u5728\u6b64\u524dBOP\u7684\u4f5c\u7528\u4e0b\u4e0d\u80fd\u5b9e\u73b0\u8fd9\u4e2a\u53cd\u5e94\u3002\u4e4b\u540e\u5229\u7528TFA\u9664\u53bbBoc\u57fa\u56e2\uff0c\u5e76\u4e14\u5b9e\u73b0\u8fd9\u4e24\u4e2a\u4f4d\u70b9\u7684\u73af\u5316\u5076\u8054\u53cd\u5e94\uff0c\u540c\u6837\u5229\u7528\u7684HATU\/DIPEA\u7684\u6761\u4ef6\uff0c\u540c\u65f6\u4f7f\u7528\u7684\u662fTHF\u7684\u5e95\u7269\u9ad8\u7a00\u91ca\u6eb6\u6db2\u3002 b \u4ef2\u80fa\u7684\u53cd\u5e94\uff1a[4] \u6b64\u5916\u4e00\u4e2a\u5927\u73af\u9170\u80fa\u5316\u7684\u7279\u6b8a\u7684\u4f8b\u5b50\uff1a \u8fd9\u662f\u4e00\u4e2a\u7ecf\u5386Staudinger\/\u6c2e\u6742Wittig\u53cd\u5e94\u4e4b\u540e\u5b9e\u73b0\u5927\u73af\u5185\u9170\u80fa\u5316\u7684\u8fc7\u7a0b REFERENCES [1] Tetrahedron Lett., 1990, 31, 205, DOI: 1016\/S0040-4039(00)94371-5 [2] Synthesis 1984, 7, 572-574. DOI: 10.1055\/s-1984-30895 [3] J. Am. Chem. Soc. 1999, 12, 127, 6355-6366, DOI: 10.1021\/ja9811243 [4] J. Am. Chem. 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