{"id":30620,"date":"2020-03-11T08:00:47","date_gmt":"2020-03-11T00:00:47","guid":{"rendered":"\/\/www.gsbet888.com\/?p=30620"},"modified":"2020-03-15T23:32:08","modified_gmt":"2020-03-15T15:32:08","slug":"%e9%99%8d%e7%b3%96%e7%a5%9e%e8%8d%af-%e4%ba%8c%e7%94%b2%e5%8f%8c%e8%83%8d%ef%bc%88metformin%ef%bc%89","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/molecule\/2020\/03\/%e9%99%8d%e7%b3%96%e7%a5%9e%e8%8d%af-%e4%ba%8c%e7%94%b2%e5%8f%8c%e8%83%8d%ef%bc%88metformin%ef%bc%89.html","title":{"rendered":"\u964d\u7cd6\u201c\u795e\u836f\u201d\u2014\u2014\u4e8c\u7532\u53cc\u80cd\uff08Metformin\uff09"},"content":{"rendered":"<h4><strong>\u4e00\u3001\u5f15\u8a00<\/strong><\/h4>\n<p>\u73b0\u4ee3\u533b\u5b66\u7684\u8fc5\u731b\u53d1\u5c55\u9020\u798f\u4e86\u65e0\u6570\u4eba\u7c7b\uff0c\u8bb8\u591a\u7591\u96be\u6742\u75c7\u548c\u6614\u65e5\u7684\u4e0d\u6cbb\u4e4b\u75c7\u9010\u6e10\u88ab\u79d1\u5b66\u653b\u514b\u3002\u7136\u800c\uff0c\u73b0\u4ee3\u533b\u5b66\u5728\u6162\u6027\u975e\u4f20\u67d3\u6027\u75be\u75c5\u9886\u57df\u4f9d\u7136\u76f8\u5bf9\u8584\u5f31\uff0c\u7cd6\u5c3f\u75c5\u6b63\u662f\u5176\u4e2d\u4e4b\u4e00\u3002\u8fd1\u4e9b\u5e74\u6765\uff0c\u7cd6\u5c3f\u75c5\u5bf9\u4eba\u7c7b\u5065\u5eb7\u7684\u5a01\u80c1\u65e5\u76ca\u52a0\u5267\uff0c\u60a3\u8005\u6570\u91cf\u6025\u5267\u4e0a\u5347\u65e0\u7591\u7ed9\u4eba\u7c7b\u5065\u5eb7\u548c\u793e\u4f1a\u53d1\u5c55\u5e26\u6765\u6c89\u91cd\u8d1f\u62c5\u3002\u6839\u636e\u56fd\u9645\u7cd6\u5c3f\u75c5\u8054\u76df\uff08IDF\uff09\u9884\u8ba1\uff0c\u52302030\u5e74\u5168\u7403\u5c06\u6709\u8fd15\u4ebf\u4eba\u7f79\u60a3\u7cd6\u5c3f\u75c5\u3002<\/p>\n<p>\u4f5c\u4e3a\u4e00\u79cd\u4ee3\u8c22\u6027\u75be\u75c5\uff0c\u7cd6\u5c3f\u75c5\u7684\u4e3b\u8981\u7279\u5f81\u662f\u60a3\u8005\u7684\u8840\u7cd6\u957f\u671f\u9ad8\u4e8e\u6807\u51c6\u503c\uff0c\u9020\u6210\u5178\u578b\u7684\u201c\u4e09\u591a\u4e00\u5c11\u201d\u75c7\u72b6\uff1a\u591a\u98df\u3001\u591a\u996e\u3001\u591a\u5c3f\u53ca\u4f53\u91cd\u4e0b\u964d\u3002\u5982\u679c\u4e0d\u8fdb\u884c\u6cbb\u7597\uff0c\u7cd6\u5c3f\u75c5\u8fd8\u4f1a\u5f15\u53d1\u8bb8\u591a\u5e76\u53d1\u75c7\uff0c\u4f8b\u5982\u89c6\u7f51\u819c\u75c5\u53d8\u3001\u80be\u75c5\u3001\u795e\u7ecf\u75c5\u53d8\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u4f24\u53e3\u6108\u5408\u7f13\u6162\u7b49\uff0c\u8fd9\u663e\u7136\u589e\u52a0\u4e86\u60a3\u8005\u7684\u8d22\u52a1\u8d1f\u62c5\u4e5f\u540c\u65f6\u5927\u5927\u964d\u4f4e\u4e86\u751f\u6d3b\u54c1\u8d28\u3002\u7cd6\u5c3f\u75c5\u6cbb\u7597\u603b\u7684\u539f\u5219\u662f\u901a\u8fc7\u6539\u53d8\u751f\u6d3b\u65b9\u5f0f\uff0c\u5305\u62ec\u996e\u98df\u63a7\u5236\u3001\u4f53\u80b2\u953b\u70bc\u3001\u51cf\u8f7b\u4f53\u91cd\uff0c\u5e76\u914d\u5408\u4e00\u5b9a\u7684\u836f\u7269\u6cbb\u7597\uff0c\u4ee5\u8fbe\u5230\u63a7\u5236\u8840\u7cd6\u3001\u9884\u9632\u5e76\u53d1\u75c7\u7684\u76ee\u7684\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/1-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30628 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/1-2.png\" alt=\"\" width=\"667\" height=\"307\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/1-2.png 1277w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/1-2-300x138.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/1-2-680x313.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/1-2-768x353.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/1-2-370x170.png 370w\" sizes=\"(max-width: 667px) 100vw, 667px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe 1 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Sharpey-Schafer\u63d0\u51fa\u7cd6\u5c3f\u75c5\u4eba\u662f\u56e0\u4e3a\u7f3a\u5c11\u80f0\u817a\u5236\u9020\u7684\u67d0\u79cd\u7269\u8d28\uff0c\u4ed6\u5c06\u8fd9\u79cd\u7269\u8d28\u547d\u540d\u4e3a\u201cinsulin\u201d\uff08\u6e90\u81ea\u62c9\u4e01\u6587\u201cinsula\u201d\uff0c\u539f\u610f\u4e3a\u5c0f\u5c9b\uff0c\u4e2d\u6587\u8bd1\u4e3a\u201c\u80f0\u5c9b\u7d20\u201d\uff09\u3002<\/p>\n<p>\u7136\u800c\uff0c\u80f0\u810f\u5728\u65b0\u9648\u4ee3\u8c22\u4e2d\u7684\u5185\u5206\u6ccc\u4f5c\u7528\u4ee5\u53ca\u80f0\u5c9b\u7d20\u662f\u5426\u771f\u5b9e\u5b58\u5728\u76f4\u52301921\u5e74\u624d\u88ab\u8fdb\u4e00\u6b65\u7814\u7a76\u8bc1\u5b9e\uff1a\u52a0\u62ff\u5927\u533b\u5b66\u5bb6\u5f17\u96f7\u5fb7\u91cc\u514b\u2022\u73ed\u5ef7\uff08Frederick Banting\uff09\u4e0e\u82cf\u683c\u5170\u751f\u7406\u5b66\u5bb6\u7ea6\u7ff0\u2022\u9ea6\u514b\u52b3\u5fb7\uff08John Macleod\uff09\u5408\u4f5c\u9996\u6b21\u4ece\u72d7\u7684\u80f0\u817a\u4e2d\u63d0\u53d6\u51fa\u80f0\u5c9b\u7d20\uff0c\u5e76\u6210\u529f\u5730\u5e94\u7528\u4e8e\u4e34\u5e8a\u6cbb\u7597\uff0c\u4e24\u4eba\u5219\u56e0\u4e3a\u53d1\u73b0\u80f0\u5c9b\u7d20\u800c\u83b7\u5f971923\u5e74\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\uff0c\u4e5f\u6210\u4e3a\u8bfa\u8d1d\u5c14\u5956\u5386\u53f2\u4e0a\u83b7\u5956\u6700\u5feb\u7684\u4e00\u6b21\u2014\u2014\u4ece\u53d1\u73b0\u5230\u83b7\u5956\u4ec5\u8017\u65f6\u4e24\u5e74\u7684\u65f6\u95f4\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/2-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30622 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/2-1.jpg\" alt=\"\" width=\"732\" height=\"241\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/2-1.jpg 1157w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/2-1-300x99.jpg 300w, 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href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/3-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30623 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/3-1.jpg\" alt=\"\" width=\"654\" height=\"377\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/3-1.jpg 1563w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/3-1-300x173.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/3-1-680x392.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/3-1-768x443.jpg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/3-1-1536x885.jpg 1536w\" sizes=\"(max-width: 654px) 100vw, 654px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe 3 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href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/4-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30624 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/4-1.jpg\" alt=\"\" width=\"647\" height=\"348\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/4-1.jpg 1398w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/4-1-300x161.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/4-1-680x366.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/4-1-768x413.jpg 768w\" sizes=\"(max-width: 647px) 100vw, 647px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe 4 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href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/5-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30625 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/5-1.jpg\" alt=\"\" width=\"685\" height=\"327\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/5-1.jpg 1338w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/5-1-300x143.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/5-1-680x324.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/5-1-768x366.jpg 768w\" sizes=\"(max-width: 685px) 100vw, 685px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe 5 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href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/6-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30626 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/6-1.jpg\" alt=\"\" width=\"564\" height=\"384\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/6-1.jpg 1100w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/6-1-300x205.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/6-1-680x464.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/6-1-768x524.jpg 768w\" sizes=\"(max-width: 564px) 100vw, 564px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe 6 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href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/7-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-30627 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/7-1.jpg\" alt=\"\" width=\"693\" height=\"184\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/7-1.jpg 1132w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/7-1-300x80.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/7-1-680x180.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/03\/7-1-768x204.jpg 768w\" sizes=\"(max-width: 693px) 100vw, 693px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe 7 \u82ef\u4e59\u53cc\u80cd\u548c\u4e01\u53cc\u80cd\u7684\u5316\u5b66\u7ed3\u6784<\/p>\n<h4><strong>\u4e94\u3001\u7ecf\u4e45\u4e0d\u8870\u7684\u4e8c\u7532\u53cc\u80cd<\/strong><\/h4>\n<p>\u5982\u4eca\uff0c\u4e8c\u7532\u53cc\u80cd\u5df2\u6210\u4e3a\u5168\u4e16\u754c\u5904\u65b9\u91cf\u6700\u5927\u7684\u53e3\u670d\u964d\u7cd6\u836f\uff0c\u6bcf\u5e74\u5e02\u573a\u9500\u91cf\u90fd\u5728\u589e\u52a0\uff0c\u79f0\u4e4b\u4e3a\u201c\u795e\u836f\u201d\u6beb\u4e0d\u4e3a\u8fc7\u3002\u4e0a\u5e02\u516d\u5341\u4f59\u8f7d\u540e\uff0c\u4e8c\u7532\u53cc\u80cd\u7684\u4f5c\u7528\u673a\u5236\u548c\u66f4\u591a\u7684\u836f\u7406\u529f\u6548\u4ecd\u5728\u7814\u7a76\u548c\u5f00\u53d1\u4e4b\u4e2d\uff0c\u5176\u4e2d\u8f83\u65e9\u88ab\u6ce8\u610f\u5230\u7684\u662f\u5176\u5bf9\u5fc3\u8840\u7ba1\u7684\u4fdd\u62a4\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u4e8c\u7532\u53cc\u80cd\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3001\u6cbb\u7597\u591a\u56ca\u5375\u5de2\u7efc\u5408\u5f81\u4f5c\u7528\u3001\u6cbb\u7597\u7532\u72b6\u817a\u75be\u75c5\u4f5c\u7528\u3001\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u7b49\u4e5f\u76f8\u7ee7\u88ab\u62a5\u9053\u5e76\u53d6\u5f97\u4e00\u5b9a\u8fdb\u5c55\u3002\u4e8c\u7532\u53cc\u80cd\u6b63\u50cf\u4e00\u68f5\u7115\u53d1\u65b0\u751f\u7684\u8001\u6811\uff0c\u8fd8\u5728\u7ed9\u4eba\u7c7b\u5e26\u6765\u4e0d\u4e00\u6837\u7684\u60ca\u559c\u3002<\/p>\n<h4><strong>\u516d\u3001\u7ed3\u675f\u8bed<\/strong><\/h4>\n<p>\u867d\u7136\u4e8c\u7532\u53cc\u80cd\u5e76\u4e0d\u50cf\u5176\u4ed6\u8bb8\u591a\u836f\u7269\u4e00\u6837\u76f4\u63a5\u6765\u6e90\u4e8e\u5929\u7136\u4ea7\u7269\uff0c\u4f46\u5b83\u79bb\u4e0d\u5f00\u4eba\u4eec\u5bf9\u5929\u7136\u4ea7\u7269\u5c71\u7f8a\u8c46\u78b1\u7684\u7814\u7a76\u79ef\u7d2f\u548c\u957f\u671f\u5173\u6ce8\u3002\u968f\u7740\u591a\u5b66\u79d1\u7684\u76f8\u4e92\u6e17\u900f\u4e0e\u4ea4\u53c9\uff0c\u5c24\u5176\u662f\u5929\u7136\u4ea7\u7269\u7814\u7a76\u4e0e\u5206\u5b50\u751f\u7269\u5b66\u7684\u7ed3\u5408\u65e5\u76ca\u7d27\u5bc6\uff0c\u5929\u7136\u836f\u7269\u5f00\u53d1\u8fce\u6765\u4e86\u4e00\u4e2a\u65b0\u7684\u9ec4\u91d1\u65f6\u671f\uff0c\u76f8\u4fe1\u672a\u6765\u4f1a\u6709\u66f4\u591a\u7684\u836f\u7269\u88ab\u53d1\u73b0\uff0c\u4e3a\u4eba\u7c7b\u5065\u5eb7\u4e8b\u4e1a\u505a\u51fa\u8d21\u732e\uff0c\u4e8c\u7532\u53cc\u80cd\u4e5f\u5b9a\u4f1a\u5728\u672a\u6765\u7115\u53d1\u65b0\u7684\u6d3b\u529b\u3002<\/p>\n<h4><strong>\u53c2\u8003\u8d44\u6599<\/strong><\/h4>\n<ul style=\"list-style-type: disc;\">\n<li>[1] \u7fc1\u5efa\u5e73. \u4e2d\u56fd 2 \u578b\u7cd6\u5c3f\u75c5\u9632\u6cbb\u6307\u5357 (2013\u5e74\u7248)[J]. \u4e2d\u534e\u7cd6\u5c3f\u75c5\u6742\u5fd7, 2014, 7(4): 4.<\/li>\n<li>[2] \u5468\u8389, \u5b59\u5b50\u6797. 2 \u578b\u7cd6\u5c3f\u75c5\u75c5\u56e0\u7814\u7a76\u8fdb\u5c55[J]. \u5b9e\u7528\u7cd6\u5c3f\u75c5\u6742\u5fd7, 2008, 4(2): 56-57.<\/li>\n<li>[3] Bailey C J. Metformin: historical overview[J]. Diabetologia, 2017, 60 (9): 1566-1576.<\/li>\n<li>[4] \u4ed8\u708e,\u7b49. \u5929\u7136\u836f\u7269\u5316\u5b66\u53f2\u8bdd\uff1a\u4e8c\u7532\u53cc\u80cd60\u5e74\u2014\u2014\u5c71\u7f8a\u8c46\u5f00\u542f\u7684\u7ecf\u5178\u964d\u7cd6\u836f\u7269[J].\u4e2d\u8349\u836f, 2017, 48 (22): 4591-4600.<\/li>\n<li>[5] \u5218\u8d85, \u7b49. \u4e8c\u7532\u53cc\u80cd\u7684\u964d\u7cd6\u5916\u4f5c\u7528[J].\u4e34\u5e8a\u836f\u7269\u6cbb\u7597\u6742\u5fd7, 2013, 11(1): 8-11.<\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u4e00\u3001\u5f15\u8a00 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\u4e2d\u56fd 2 \u578b\u7cd6\u5c3f\u75c5\u9632\u6cbb\u6307\u5357 (2013\u5e74\u7248)[J]. \u4e2d\u534e\u7cd6\u5c3f\u75c5\u6742\u5fd7, 2014, 7(4): 4. [2] \u5468\u8389, \u5b59\u5b50\u6797. 2 \u578b\u7cd6\u5c3f\u75c5\u75c5\u56e0\u7814\u7a76\u8fdb\u5c55[J]. \u5b9e\u7528\u7cd6\u5c3f\u75c5\u6742\u5fd7, 2008, 4(2): 56-57. [3] Bailey C J. Metformin: historical overview[J]. Diabetologia, 2017, 60 (9): 1566-1576. [4] \u4ed8\u708e,\u7b49. \u5929\u7136\u836f\u7269\u5316\u5b66\u53f2\u8bdd\uff1a\u4e8c\u7532\u53cc\u80cd60\u5e74\u2014\u2014\u5c71\u7f8a\u8c46\u5f00\u542f\u7684\u7ecf\u5178\u964d\u7cd6\u836f\u7269[J].\u4e2d\u8349\u836f, 2017, 48 (22): 4591-4600. 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