{"id":31390,"date":"2020-04-23T08:00:05","date_gmt":"2020-04-23T00:00:05","guid":{"rendered":"\/\/www.gsbet888.com\/?p=31390"},"modified":"2020-04-19T18:24:04","modified_gmt":"2020-04-19T10:24:04","slug":"ronald-breslow","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/2020\/04\/ronald-breslow.html","title":{"rendered":"Ronald Breslow"},"content":{"rendered":"<p>\u672c\u6587\u4f5c\u8005\uff1aalberto-caeiro<\/p>\n<p>Ronald Breslow\uff081931\u5e743\u670814\u65e5-2017\u5e7410\u670825\u65e5\uff09\uff0c\u7f8e\u56fd\u8457\u540d\u6709\u673a\u5316\u5b66\u5bb6\uff0c\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u6559\u6388<sup>[1]<\/sup>\uff0c\u5176\u5b66\u751f\u5305\u62ec<a href=\"\/\/www.gsbet888.com\/chemists\/2015\/02\/post-3639.html\">Robert Grubbs<\/a>\u3001<a href=\"\/\/www.gsbet888.com\/chemists\/2018\/01\/larry-e-overman.html\">Larry Overman<\/a>\u3001<a href=\"\/\/www.gsbet888.com\/chemists\/2015\/02\/robert-g-bergman.html\">Robert Bergman<\/a>\u7b49\u5316\u5b66\u5bb6\u3002\u56fe\u7247\uff1a<a href=\"m.columbia.edu\/node\/3191\/slideshow\/11\/5\">\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66<\/a>\u3002<\/p>\n<h4><strong>\u7ecf\u5386<\/strong><\/h4>\n<ul style=\"list-style-type: circle;\">\n<li>1952 Harvard University B.S.<\/li>\n<li>1955 Harvard University Ph.D. (Prof. R. B. Woodward)<\/li>\n<li>1955 Cambridge University Ph. D. (Prof. Lord Todd)<\/li>\n<li>1956 Columbia University Associate professor \u2014 Professor<\/li>\n<\/ul>\n<h4><strong>\u83b7\u5956\u7ecf\u5386<\/strong><\/h4>\n<ul style=\"list-style-type: circle;\">\n<li>1966 ACS Award in Pure Chemistry<\/li>\n<li>1966 Fresenius Award of Phi Lambda Upsilon<\/li>\n<li>1969 Baekeland Medal<\/li>\n<li>1972 Centenary Medal<\/li>\n<li>1974 Harrison Howe Award<\/li>\n<li>1977 Remsen Prize<\/li>\n<li>1978 Roussel Prize in Steroids<\/li>\n<li>1980 James Flack Norris Prize in Physical Organic Chemistry of ACS<\/li>\n<li>1984 Richards Medal<\/li>\n<li>1987 Arthur C. Cope Award<\/li>\n<li>1988 Kenner Award<\/li>\n<li>1989 Nichols Medal<\/li>\n<li>1989 National Academy of Sciences Award in Chemistry<\/li>\n<li>1990 the Allan Day Award<\/li>\n<li>1990 Paracelsus Award and Medal of the Swiss Chemical Society<\/li>\n<li>1991 U.S. National Medal of Science<\/li>\n<li>1999 Priestley Medal<\/li>\n<li>2000 New York City Mayor\u2019s Award in Science<\/li>\n<li>2002 ACS Bader Award in Bioorganic or Bioinorganic Chemistry<\/li>\n<li>2002 Esselen Award for Chemistry<\/li>\n<li>2003 Welch Award in Chemistry<\/li>\n<li>2004 Willard Gibbs Award<\/li>\n<li>2005 Kosolapoff Award<\/li>\n<li>2006 Othmer Gold Medal<\/li>\n<li>2006 Paul Gassman Medal<\/li>\n<li>2007 Organic Syntheses\/Wiley Award<\/li>\n<li>2014 American Institute of Chemists Gold Medal<\/li>\n<\/ul>\n<h4><strong>\u5de5\u4f5c\u4ecb\u7ecd<\/strong><\/h4>\n<p><span style=\"color: #0000ff;\"><strong><em>1. Cyclopropenyl cation chemistry<\/em><\/strong><\/span><\/p>\n<p>1957\u5e74\uff0cBreslow\u6559\u6388\u53d1\u8868\u4e86\u4ed6\u5728\u73af\u4e19\u70ef\u57fa\u6b63\u79bb\u5b50\u7684\u5408\u6210\uff0c\u73af\u4e19\u70ef\u57fa\u6b63\u79bb\u5b50\u662f\u78b3\u539f\u5b50\u6570\u6700\u5c11\u7684\u82b3\u9999\u4f53\u7cfb<sup>[2]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/1-6.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-31395 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/1-6.jpg\" alt=\"\" width=\"559\" height=\"157\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/1-6.jpg 706w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/1-6-300x84.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/1-6-680x191.jpg 680w\" sizes=\"(max-width: 559px) 100vw, 559px\" \/><\/a><\/p>\n<p><span style=\"color: #0000ff;\"><strong><em>2. Analysis of thiamine-catalyzed benzoin condensation reaction<\/em><\/strong><\/span><\/p>\n<p>\u76f8\u8f83\u4e8e\u4f20\u7edf\u7684\u4f7f\u7528\u6c30\u57fa\u79bb\u5b50\u4f5c\u4e3a\u4eb2\u6838\u8bd5\u5242\uff0cBreslow\u6559\u6388\u4f7f\u7528\u786b\u80fa\u7d20\u4f5c\u4e3a\u4eb2\u6838\u8bd5\u5242\u5b9e\u73b0\u4e86<a href=\"\/\/www.gsbet888.com\/reactions\/2014\/06\/%e5%ae%89%e6%81%af%e9%a6%99%e7%bc%a9%e5%90%88%e5%8f%8d%e5%ba%94benzoin-condensation.html\">\u5b89\u606f\u9999\u7f29\u5408<\/a>\u3002\u5728\u8be5\u53cd\u5e94\u7684\u7814\u7a76\u4e2d\uff0cBreslow\u6559\u6388\u63a8\u6d4b\u4e86\u53cd\u5e94\u4e2d\u53ef\u80fd\u7684Breslow\u4e2d\u95f4\u4f53\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/2-3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-31392 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/2-3.jpg\" alt=\"\" width=\"563\" height=\"213\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/2-3.jpg 563w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/2-3-300x113.jpg 300w\" sizes=\"(max-width: 563px) 100vw, 563px\" \/><\/a><\/p>\n<p style=\"text-align: center;\"><em>NHC catalyzed benzoin condensation reaction<\/em><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3-3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-31393 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3-3.jpg\" alt=\"\" width=\"440\" height=\"136\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3-3.jpg 440w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3-3-300x93.jpg 300w\" sizes=\"(max-width: 440px) 100vw, 440px\" \/><\/a><\/p>\n<p style=\"text-align: center;\"><em>Thiamine &amp; Breslow intermediate<\/em><\/p>\n<p><span style=\"color: #0000ff;\"><strong><em>3. Biomimetic Chemistry <sup>[3]<\/sup><\/em><\/strong><\/span><\/p>\n<p>Breslow\u6559\u6388\u5728\u5176\u4eba\u5de5\u9176\uff08artificial enzyme\uff09\u5de5\u4f5c\u7684\u57fa\u7840\u4e0a\uff0c\u63d0\u51fa\u5e76\u5f00\u521b\u4e86\u4eff\u751f\u5316\u5b66\u7684\u6982\u5ff5\u548c\u7814\u7a76\u9886\u57df\u3002\u901a\u8fc7\u5316\u5b66\u65b9\u6cd5\uff0c\u5982\u5408\u6210\u4e0e\u5929\u7136\u5c0f\u5206\u5b50\u6216\u5927\u5206\u5b50\u76f8\u4f3c\u7684\u7269\u8d28\uff0c\u5728\u751f\u547d\u4f53\u7cfb\u5916\u6a21\u62df\u751f\u7269\u6709\u673a\u4f53\u7cfb\u7684\u529f\u80fd\u3002<\/p>\n<p><span style=\"color: #0000ff;\"><strong><em>4. Discovery of HDAC inhibitor SAHA<\/em><\/strong><\/span><\/p>\n<p>Breslow\u6559\u6388\u53d1\u73b0\u4e86HDAC\u6291\u5236\u5242suberanilohydroxamic acid<sup>[4]<\/sup>\uff08\u6b21\u82ef\u80fa\u57fa\u5f02\u7f9f\u809f\u9178\uff0cSAHA; \u4f0f\u7acb\u8bfa\u4ed6\uff09\uff08\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176histone deacetylase, HDAC\uff09\u3002 SAHA\u4e8e2006\u5e74\u5728\u7f8e\u56fd\u63a8\u51fa\uff0c\u662f\u7b2c\u4e00\u79cd\u4e0eHDAC\u6d3b\u6027\u4e2d\u5fc3\u7ed3\u5408\u5e76\u5728\u8be5\u4f4d\u70b9\u87af\u5408\u950c\u79bb\u5b50\u7684HDAC\u6291\u5236\u5242\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/4-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-31394 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/4-2.jpg\" alt=\"\" width=\"426\" height=\"419\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/4-2.jpg 426w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/4-2-300x295.jpg 300w\" sizes=\"(max-width: 426px) 100vw, 426px\" \/><\/a><\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] Obituary, Ronald Breslow (1931\u20132017). Schepartz A. Bergman R. Grubbs R. H. <em>Angew. Chem. Int. Ed. <\/em><strong>2018<\/strong>, <em>57<\/em>, 37. <a href=\"http:\/\/dx.doi.org\/10.1002\/anie.201711641\">DOI: 10.1002\/anie.201711641<\/a>.<\/li>\n<li>[2] Breslow, R. <em>J. Am. Chem. Soc.<\/em> <strong>1957<\/strong>, <em>79<\/em>, 5318. <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja01576a067\">DOI: 10.1021\/ja01576a067<\/a>.<\/li>\n<li>[3] Breslow, R. <em>J. Am. Chem. Soc.<\/em> <strong>1970<\/strong>, <em>92<\/em>, 1075. <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja00707a062?journalCode=jacsat&amp;quickLinkVolume=92&amp;quickLinkPage=1075&amp;selectedTab=citation&amp;volume=92\">DOI: 10.1021\/ja00707a062<\/a>.<\/li>\n<li>[4] Breslow, R. <em>Nature<\/em> <strong>1999<\/strong>, <em>401<\/em>, 188. <a href=\"https:\/\/www.nature.com\/articles\/43710\">DOI: 10.1038\/43710<\/a>.<\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1aalberto-caeiro Ronald Breslow\uff081931\u5e743\u670814\u65e5-2017\u5e7410\u670825\u65e5\uff09\uff0c\u7f8e\u56fd\u8457\u540d\u6709\u673a\u5316\u5b66\u5bb6\uff0c\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u6559\u6388[1]\uff0c\u5176\u5b66\u751f\u5305\u62ecRobert Grubbs\u3001Larry Overman\u3001Robert Bergman\u7b49\u5316\u5b66\u5bb6\u3002\u56fe\u7247\uff1a\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u3002 \u7ecf\u5386 1952 Harvard University B.S. 1955 Harvard University Ph.D. (Prof. R. B. Woodward) 1955 Cambridge University Ph. D. (Prof. Lord Todd) 1956 Columbia University Associate professor \u2014 Professor \u83b7\u5956\u7ecf\u5386 1966 ACS Award in Pure Chemistry 1966 Fresenius Award of Phi Lambda Upsilon 1969 Baekeland Medal 1972 Centenary Medal 1974 Harrison Howe Award 1977 Remsen Prize 1978 Roussel Prize in Steroids 1980 James Flack Norris Prize in Physical Organic Chemistry of ACS 1984 Richards Medal 1987 Arthur C. Cope Award 1988 Kenner Award 1989 Nichols Medal 1989 National Academy of Sciences Award in Chemistry 1990 the Allan Day Award 1990 Paracelsus Award and Medal of [&hellip;]","protected":false},"author":26,"featured_media":31396,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[212],"tags":[2556,2555,2554,2557],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/F-3.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-8ai","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/31390"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=31390"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/31390\/revisions"}],"predecessor-version":[{"id":31637,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/31390\/revisions\/31637"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/31396"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=31390"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=31390"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=31390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}