{"id":31754,"date":"2020-05-11T08:00:27","date_gmt":"2020-05-11T00:00:27","guid":{"rendered":"\/\/www.gsbet888.com\/?p=31754"},"modified":"2020-07-19T11:55:34","modified_gmt":"2020-07-19T03:55:34","slug":"ishihara-%e7%8e%af%e9%86%9a%e5%8c%96","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2020\/05\/ishihara-%e7%8e%af%e9%86%9a%e5%8c%96.html","title":{"rendered":"Ishihara \u73af\u919a\u5316"},"content":{"rendered":"<h4><strong>\u6982\u8981<\/strong><\/h4>\n<p>2010\u5e74\u65e5\u672c\u540d\u53e4\u5c4b\u5927\u5b66\u5de5\u5b66\u9662 (\u540d\u53e4\u5c4b\u5927\u5b66\u5de5\u5b66\u7814\u7a76\u79d1, Graduate School of Engineering, Nagoya University)\u7684\u77f3\u539f\u4e00\u5f70 (\u77f3\u539f\u4e00\u5f70, Ishihara Kazuaki)\u7814\u7a76\u5ba4\u62a5\u9053\u4e86\u9996\u4f8b\u7531\u6b21\u7898\u9178\u5b63\u94f5\u76d0\/\u4e9a\u7898\u9178\u5b63\u94f5\u76d0(quaternary ammonium hypoiodite \/ quaternary ammonium iodite, \u901a\u8fc7TBAI (tetrabutylammonium iodide)\u4e0eH<sub>2<\/sub>O<sub>2<\/sub>\u6216TBHP\u539f\u4f4d\u751f\u6210)\u53c2\u4e0e\u7684\u916e\u915a(ketophenol)\u7684\u6c27\u5316\u73af\u919a\u5316\u8fc7\u7a0b\uff0c\u6210\u529f\u5b8c\u6210\u4e862-\u9170\u57fa-2,3-\u4e8c\u6c22\u82ef\u5e76\u544b\u5583\u7c7b\u5316\u5408\u7269\u7684\u6784\u5efa<sup>[1]<\/sup>\u3002\u540c\u65f6\uff0cIshihara\u8fdb\u4e00\u6b65\u91c7\u7528\u539f\u4f4d\u4ea7\u751f\u7684\u624b\u6027\u6b21\u7898\u9178\u53ca\u4e9a\u7898\u9178N-\u87ba\u73af\u5b63\u94f5\u76d0(N-spiro-type quaternary ammonium hypoiodite \/iodite)\u50ac\u5316\u5242\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u916e\u915a(ketophenol)\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c27\u5316\u73af\u919a\u5316<sup>[1]<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-33942\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4e9a0ba2491dfdebf5689563327de8ce.png\" alt=\"\" width=\"900\" height=\"335\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4e9a0ba2491dfdebf5689563327de8ce.png 900w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4e9a0ba2491dfdebf5689563327de8ce-300x112.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4e9a0ba2491dfdebf5689563327de8ce-680x253.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4e9a0ba2491dfdebf5689563327de8ce-768x286.png 768w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>2016\u5e74\uff0cIshihara\u91c7\u7528CHP (cumene hydroperoxide)\u4ee3\u66ffH<sub>2<\/sub>O<sub>2<\/sub>\u6216TBHP\uff0c\u5c06\u4e0a\u8ff0\u6761\u4ef6\u5e94\u7528\u4e8e\u03b4-\u7f9f\u57fa\u916e\u884d\u751f\u7269\uff0c\u5e76\u987a\u5229\u5b8c\u6210\u624b\u60272-\u9170\u57fa\u56db\u6c22\u544b\u5583\u9aa8\u67b6\u7684\u6784\u5efa<sup>[2]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/2-9.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-31756 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/2-9.png\" alt=\"\" width=\"800\" height=\"201\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/2-9.png 1373w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/2-9-300x75.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/2-9-680x171.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/2-9-768x193.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a><\/p>\n<p>\u6587\u732e\u4e2d\u5c06\u4e0a\u8ff0\u65b9\u6cd5\u5b66\u79f0\u4e3aIshihara\u73af\u919a\u5316 (Ishihara cycloetherification)\u3002\u8be5\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\u3001\u73af\u5883\u53cb\u597d\uff0c\u5177\u6709\u4f18\u826f\u7684\u5316\u5b66\u9009\u62e9\u6027(\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u65e0\u915a\u7684\u6c27\u5316\u4ea7\u7269\u751f\u6210)\u4e0e\u4f18\u826f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u3002\u540c\u65f6\uff0c\u751f\u6210\u7684\u624b\u60272-\u9170\u57fa-2,3-\u4e8c\u6c22\u82ef\u5e76\u544b\u5583\u4e3a\u5404\u7c7b\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u5408\u6210\u8fc7\u7a0b\u4e2d\u7684\u5173\u952e\u780c\u5757<sup>[3]-[7]<\/sup>\u3002<\/p>\n<h4><strong>\u57fa\u672c\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] M. Uyanik, H. Okamoto, T. Yasui, K. Ishihara, Science 2010, 328, 1376. doi: <a href=\"https:\/\/science.sciencemag.org\/content\/328\/5984\/1376\">10.1126\/science.1188217.<\/a><\/li>\n<li>[2] M. Uyanik, H. Hayashi, H. Iwata, K. Ishihara, Chem. Lett. 2016, 45, 353. doi: <a href=\"https:\/\/doi.org\/10.1246\/cl.160004\">10.1246\/cl.160004<\/a>.<\/li>\n<li>[3] W. Wei, Y. Wang, J. Yin, J. Xue, Y. Li, Org. Lett. 2012, 14, 1158. doi: <a href=\"https:\/\/doi.org\/10.1021\/ol300107v\">10.1021\/ol300107v<\/a>.<\/li>\n<li>[4] L. Wei, J. Xue, H. Liu, W. Wang, Y. Li, Org. Lett. 2012, 14, 5302. doi: <a href=\"https:\/\/doi.org\/10.1021\/ol3024874\">10.1021\/ol3024874<\/a>.<\/li>\n<li>[5] M. Uyanik, H. Hayashi, K. Ishihara, Science 2014, 345, 291. doi: <a href=\"https:\/\/science.sciencemag.org\/content\/345\/6194\/291\">10.1126\/science.1254976.<\/a><\/li>\n<li>[6] B. J. Nachtsheim, Science 2014, 345, 270. doi:<a href=\"https:\/\/science.sciencemag.org\/content\/345\/6194\/270\"> 10.1126\/science.1257347.<\/a><\/li>\n<li>[7] T. Netscher, Angew. Chem. Int. Ed. 2014, 53, 14313. doi: <a href=\"https:\/\/doi.org\/10.1002\/anie.201409826\">10.1002\/anie.201409826<\/a>.<\/li>\n<\/ul>\n<h4><strong>\u53cd\u5e94\u673a\u7406<\/strong><\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3a.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-31757 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3a.png\" alt=\"\" width=\"729\" height=\"400\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3a.png 1529w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3a-300x164.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3a-680x373.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3a-768x421.png 768w\" sizes=\"(max-width: 729px) 100vw, 729px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3b.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-31758 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3b.png\" alt=\"\" width=\"713\" height=\"344\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3b.png 1262w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3b-300x145.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3b-680x328.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3b-768x371.png 768w\" sizes=\"(max-width: 713px) 100vw, 713px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3c.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-31759 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3c.png\" alt=\"\" width=\"725\" height=\"406\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3c.png 1239w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3c-300x168.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3c-680x381.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3c-768x431.png 768w\" sizes=\"(max-width: 725px) 100vw, 725px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3d.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-31760 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3d.png\" alt=\"\" width=\"702\" height=\"318\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3d.png 1492w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3d-300x136.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3d-680x309.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/3d-768x348.png 768w\" sizes=\"(max-width: 702px) 100vw, 702px\" \/><\/a><\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] M. Uyanik, K. Ishihara, Chem. Cat. Chem. 2012, 4, 177. doi: <a href=\"https:\/\/doi.org\/10.1002\/cctc.201100352\">10.1002\/cctc.201100352<\/a>.<\/li>\n<li>[2] X. Li, C. Zhou, X. Xu, ARKIVOC 2012, (ix), 150. doi: <a href=\"https:\/\/doi.org\/10.3998\/ark.5550190.0013.913\">10.3998\/ark.5550190.0013.913<\/a>.<\/li>\n<li>[3] X. Wu, J. Gong, X. Qi, Org. Biomol. Chem. 2014, 12, 5807. doi: <a href=\"https:\/\/doi.org\/10.1039\/C4OB00276H\">10.1039\/C4OB00276H<\/a>.<\/li>\n<li>[4] P. Finkbeiner, B. J. Nachtsheim, Synthesis 2013, 45, 979. doi: <a href=\"https:\/\/www.thieme-connect.de\/products\/ejournals\/abstract\/10.1055\/s-0032-1318330\">10.1055\/s-0032-1318330.<\/a><\/li>\n<li>[5] Z. Liu, J. Zhang, S. Chen, E. Shi, Y. Xu, X. Wan, Angew. Chem. Int. Ed. 2012, 51, 3231. doi: <a href=\"https:\/\/doi.org\/10.1002\/anie.201108763\">10.1002\/anie.201108763<\/a>.<\/li>\n<li>[6] W. Xu, B. J. Nachtsheim, Org. Lett. 2015, 17, 1585. doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.5b00466\">10.1021\/acs.orglett.5b00466<\/a>.<\/li>\n<\/ul>\n<h4><strong>\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/h4>\n<p>tocopherols\u7684\u4e0d\u5bf9\u79f0\u5408\u6210<sup>[1]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/4-8.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-31761 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/4-8.png\" alt=\"\" width=\"768\" height=\"248\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/4-8.png 1375w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/4-8-300x97.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/4-8-680x220.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/4-8-768x248.png 768w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><\/a><\/p>\n<p>rac-\u03b3-rubromycin\u7684\u5408\u6210<sup>[2]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/5-6.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-31762 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/5-6.png\" alt=\"\" width=\"737\" height=\"260\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/5-6.png 1369w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/5-6-300x106.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/5-6-680x240.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/5-6-768x271.png 768w\" sizes=\"(max-width: 737px) 100vw, 737px\" \/><\/a><\/p>\n<p>2-\u9170\u57fa\u56db\u6c22\u544b\u5583\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210<sup>[3]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/6-7.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-31763 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/6-7.png\" alt=\"\" width=\"723\" height=\"189\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/6-7.png 1359w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/6-7-300x78.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/6-7-680x178.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/6-7-768x201.png 768w\" sizes=\"(max-width: 723px) 100vw, 723px\" \/><\/a><\/p>\n<h4><strong>\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/h4>\n<p><span style=\"color: #0000ff\"><strong>Ishihara <\/strong><strong>\u73af\u919a\u5316<\/strong><\/span><\/p>\n<p>\u5ba4\u6e29\u4e0b\uff0c\u5411\u916e\u915a (1 eq.)\u4e0eTBAI (0.10 eq.)\u7684THF\u6216\u4e59\u8148\u6eb6\u6db2(\u7ef4\u6301\u5e95\u7269\u6d53\u5ea6\u4e3a0.2 M) \u4e2d\u52a0\u5165\u8d28\u91cf\u5206\u6570\u4e3a30 %\u7684\u8fc7\u6c27\u5316\u6c22 (2 eq.)\u6c34\u6eb6\u6db2\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\u8fdb\u884c\u6405\u62cc\uff0c\u901a\u8fc7TLC\u76d1\u63a7\uff0c\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u52a0\u6c34\u7a00\u91ca\uff0c\u968f\u540e\uff0c\u52a0\u5165\u4e59\u9178\u4e59\u916f\u8fdb\u884c\u8403\u53d6\u3002\u5c06\u5408\u5e76\u7684\u6709\u673a\u76f8\u4f9d\u6b21\u901a\u8fc7\u9971\u548c\u4e9a\u786b\u9178\u94a0\u6eb6\u6db2\u3001\u9971\u548c\u98df\u76d0\u6c34\u53ca\u6c34\u8fdb\u884c\u6d17\u6da4\u3002\u518d\u52a0\u5165\u65e0\u6c34\u786b\u9178\u94a0\u8fdb\u884c\u5e72\u71e5\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u3002\u5c06\u6b8b\u4f59\u7269\u901a\u8fc7\u77ed\u7845\u80f6\u67f1 (\u6b63\u5df1\u70f7\/\u4e59\u9178\u4e59\u916f 5:1 v\/v \u4f5c\u4e3a\u6d17\u8131\u5242)\u8fdb\u884c\u7eaf\u5316\uff0c\u83b7\u5f97\u6700\u7ec8\u76ee\u6807\u4ea7\u7269\u3002<\/p>\n<p><span style=\"color: #0000ff\"><strong>\u8fc7\u6c27\u5316\u6c22\u53c2\u4e0e\u7684<\/strong><strong>Ishihara<\/strong><strong>\u73af\u919a\u5316<\/strong><\/span><\/p>\n<p>\u5ba4\u6e29\u4e0b\uff0c\u5411\u916e\u915a (1 eq.)\u4e0e\u624b\u6027N-\u87ba\u73af\u5b63\u94f5\u76d0 (0.10 eq.)\u7684\u4e59\u919a-\u6c34\u6eb6\u6db2(\u4f53\u79ef\u6bd4\u4e3a5:1,\u7ef4\u6301\u5e95\u7269\u6d53\u5ea6\u4e3a0.02 M)\u4e2d\u52a0\u5165\u8d28\u91cf\u5206\u6570\u4e3a30 %\u7684\u8fc7\u6c27\u5316\u6c22 (2 eq.)\u6c34\u6eb6\u6db2\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\u8fdb\u884c\u6405\u62cc\uff0c\u901a\u8fc7TLC\u76d1\u63a7\uff0c\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u52a0\u6c34\u7a00\u91ca\uff0c\u968f\u540e\uff0c\u52a0\u5165\u4e59\u9178\u4e59\u916f\u8fdb\u884c\u8403\u53d6\u3002\u5c06\u5408\u5e76\u7684\u6709\u673a\u76f8\u4f9d\u6b21\u901a\u8fc7\u9971\u548c\u4e9a\u786b\u9178\u94a0\u6eb6\u6db2\u3001\u9971\u548c\u98df\u76d0\u6c34\u53ca\u6c34\u8fdb\u884c\u6d17\u6da4\u3002\u518d\u52a0\u5165\u65e0\u6c34\u786b\u9178\u94a0\u8fdb\u884c\u5e72\u71e5\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u3002\u5c06\u6b8b\u4f59\u7269\u901a\u8fc7\u77ed\u7845\u80f6\u67f1 (\u6b63\u5df1\u70f7\/\u4e59\u9178\u4e59\u916f 5:1 v\/v \u4f5c\u4e3a\u6d17\u8131\u5242)\u8fdb\u884c\u7eaf\u5316\uff0c\u83b7\u5f97\u76f8\u5e94\u624b\u6027\u4ea7\u7269\u3002\u6700\u540e\uff0c\u901a\u8fc7HPLC\u6d4b\u5b9a\u5176ee%\u3002<\/p>\n<p><span style=\"color: #0000ff\"><strong>TBHP<\/strong><strong>\u53c2\u4e0e\u7684<\/strong><strong>Ishihara<\/strong><strong>\u73af\u919a\u5316<\/strong><\/span><\/p>\n<p>\u5ba4\u6e29\u4e0b\uff0c\u5411\u916e\u915a (1 eq.)\u4e0e\u624b\u6027N-\u87ba\u73af\u5b63\u94f5\u76d0 (0.01 eq.)\u7684\u4e59\u919a\u6eb6\u6db2(\u7ef4\u6301\u5e95\u7269\u6d53\u5ea6\u4e3a0.1 M)\u4e2d\u52a0\u5165\u65e0\u6c34TBHP (5.5 M \u7678\u70f7\u6eb6\u6db2, 2 eq.)\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\u8fdb\u884c\u6405\u62cc\uff0c\u901a\u8fc7TLC\u76d1\u63a7\uff0c\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u52a0\u6c34\u7a00\u91ca\uff0c\u968f\u540e\uff0c\u52a0\u5165\u4e59\u9178\u4e59\u916f\u8fdb\u884c\u8403\u53d6\u3002\u5c06\u5408\u5e76\u7684\u6709\u673a\u76f8\u4f9d\u6b21\u901a\u8fc7\u9971\u548c\u4e9a\u786b\u9178\u94a0\u6eb6\u6db2\u3001\u9971\u548c\u98df\u76d0\u6c34\u53ca\u6c34\u8fdb\u884c\u6d17\u6da4\u3002\u518d\u52a0\u5165\u65e0\u6c34\u786b\u9178\u94a0\u8fdb\u884c\u5e72\u71e5\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u3002\u5c06\u6b8b\u4f59\u7269\u901a\u8fc7\u77ed\u7845\u80f6\u67f1 (\u6b63\u5df1\u70f7\/\u4e59\u9178\u4e59\u916f 5:1 v\/v \u4f5c\u4e3a\u6d17\u8131\u5242)\u8fdb\u884c\u7eaf\u5316\uff0c\u83b7\u5f97\u76f8\u5e94\u624b\u6027\u4ea7\u7269\u3002\u6700\u540e\uff0c\u901a\u8fc7HPLC\u6d4b\u5b9a\u5176ee%\u3002<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] M. Uyanik, H. Hayashi, K. Ishihara, Science 2014, 345, 291. doi: <a href=\"https:\/\/science.sciencemag.org\/content\/345\/6194\/291\">10.1126\/science.1254976.<\/a><\/li>\n<li>[2] L. Wei, J. Xue, H. Liu, W. Wang, Y. Li, Org. Lett. 2012, 14, 5302. doi: <a href=\"https:\/\/doi.org\/10.1021\/ol3024874\">10.1021\/ol3024874<\/a>.<\/li>\n<li>[3] M. Uyanik, H. Hayashi, H. Iwata, K. Ishihara, Chem. Lett. 2016, 45, 353. doi: <a href=\"https:\/\/doi.org\/10.1246\/cl.160004\">10.1246\/cl.160004<\/a><\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 2010\u5e74\u65e5\u672c\u540d\u53e4\u5c4b\u5927\u5b66\u5de5\u5b66\u9662 (\u540d\u53e4\u5c4b\u5927\u5b66\u5de5\u5b66\u7814\u7a76\u79d1, Graduate School of Engineering, Nagoya University)\u7684\u77f3\u539f\u4e00\u5f70 (\u77f3\u539f\u4e00\u5f70, Ishihara Kazuaki)\u7814\u7a76\u5ba4\u62a5\u9053\u4e86\u9996\u4f8b\u7531\u6b21\u7898\u9178\u5b63\u94f5\u76d0\/\u4e9a\u7898\u9178\u5b63\u94f5\u76d0(quaternary ammonium hypoiodite \/ quaternary ammonium iodite, \u901a\u8fc7TBAI (tetrabutylammonium iodide)\u4e0eH2O2\u6216TBHP\u539f\u4f4d\u751f\u6210)\u53c2\u4e0e\u7684\u916e\u915a(ketophenol)\u7684\u6c27\u5316\u73af\u919a\u5316\u8fc7\u7a0b\uff0c\u6210\u529f\u5b8c\u6210\u4e862-\u9170\u57fa-2,3-\u4e8c\u6c22\u82ef\u5e76\u544b\u5583\u7c7b\u5316\u5408\u7269\u7684\u6784\u5efa[1]\u3002\u540c\u65f6\uff0cIshihara\u8fdb\u4e00\u6b65\u91c7\u7528\u539f\u4f4d\u4ea7\u751f\u7684\u624b\u6027\u6b21\u7898\u9178\u53ca\u4e9a\u7898\u9178N-\u87ba\u73af\u5b63\u94f5\u76d0(N-spiro-type quaternary ammonium hypoiodite \/iodite)\u50ac\u5316\u5242\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u916e\u915a(ketophenol)\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c27\u5316\u73af\u919a\u5316[1]\u3002 &nbsp; 2016\u5e74\uff0cIshihara\u91c7\u7528CHP (cumene hydroperoxide)\u4ee3\u66ffH2O2\u6216TBHP\uff0c\u5c06\u4e0a\u8ff0\u6761\u4ef6\u5e94\u7528\u4e8e\u03b4-\u7f9f\u57fa\u916e\u884d\u751f\u7269\uff0c\u5e76\u987a\u5229\u5b8c\u6210\u624b\u60272-\u9170\u57fa\u56db\u6c22\u544b\u5583\u9aa8\u67b6\u7684\u6784\u5efa[2]\u3002 \u6587\u732e\u4e2d\u5c06\u4e0a\u8ff0\u65b9\u6cd5\u5b66\u79f0\u4e3aIshihara\u73af\u919a\u5316 (Ishihara cycloetherification)\u3002\u8be5\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\u3001\u73af\u5883\u53cb\u597d\uff0c\u5177\u6709\u4f18\u826f\u7684\u5316\u5b66\u9009\u62e9\u6027(\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u65e0\u915a\u7684\u6c27\u5316\u4ea7\u7269\u751f\u6210)\u4e0e\u4f18\u826f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u3002\u540c\u65f6\uff0c\u751f\u6210\u7684\u624b\u60272-\u9170\u57fa-2,3-\u4e8c\u6c22\u82ef\u5e76\u544b\u5583\u4e3a\u5404\u7c7b\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u5408\u6210\u8fc7\u7a0b\u4e2d\u7684\u5173\u952e\u780c\u5757[3]-[7]\u3002 \u57fa\u672c\u6587\u732e [1] M. Uyanik, H. Okamoto, T. Yasui, K. Ishihara, Science 2010, 328, 1376. doi: 10.1126\/science.1188217. [2] M. Uyanik, H. Hayashi, H. Iwata, K. Ishihara, Chem. Lett. 2016, 45, 353. doi: 10.1246\/cl.160004. [3] W. Wei, Y. Wang, J. Yin, J. Xue, Y. Li, Org. Lett. 2012, 14, 1158. doi: 10.1021\/ol300107v. [4] L. Wei, J. Xue, H. Liu, W. Wang, Y. Li, Org. Lett. 2012, 14, 5302. doi: 10.1021\/ol3024874. [5] M. Uyanik, H. Hayashi, K. Ishihara, Science 2014, 345, [&hellip;]","protected":false},"author":21,"featured_media":31764,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2],"tags":[2646,1572,2645],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/04\/Ishihara-cycloetherification-asymmboy.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-8ga","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/31754"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=31754"}],"version-history":[{"count":8,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/31754\/revisions"}],"predecessor-version":[{"id":33943,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/31754\/revisions\/33943"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/31764"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=31754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=31754"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=31754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}