{"id":32140,"date":"2020-06-11T08:34:22","date_gmt":"2020-06-11T00:34:22","guid":{"rendered":"\/\/www.gsbet888.com\/?p=32140"},"modified":"2020-06-11T08:34:22","modified_gmt":"2020-06-11T00:34:22","slug":"%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9brevianamide-a%e7%9a%84%e5%85%a8%e5%90%88%e6%88%90","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2020\/06\/%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9brevianamide-a%e7%9a%84%e5%85%a8%e5%90%88%e6%88%90.html","title":{"rendered":"\u5929\u7136\u4ea7\u7269Brevianamide A\u7684\u5168\u5408\u6210"},"content":{"rendered":"

\u672c\u6587\u4f5c\u8005\uff1a\u8283\u6d0b\u96ea<\/p>\n

\u53cc\u73af\u91cd\u6c2e\u8f9b\u70f7\u7c7b[2,2,2]diazaocatne\u751f\u7269\u78b1\u5e7f\u6cdb\u5b58\u5728\u4e8e\u6d77\u6d0b\u751f\u7269\u548c\u771f\u83cc\u4e2d\uff0c\u5177\u6709\u591a\u79cd\u751f\u7269\u6d3b\u6027\u3002\u6839\u636e\u73af\u4e0a\u7684\u6c27\u5316\u7a0b\u5ea6\uff0c\u53ef\u5206\u4e3a\u5355\u6c27\u4ee3\u54cc\u55ea\u578b\uff0c\u5982\u56fe1b\u7684(-)-Paraherquamide\u3001(+)-Malbrancheamide\u3001(+)-Chrysogenamide A;\u53cc\u6c27\u4ee3\u54cc\u55ea\u578b\uff0c\u5982\u56fe1c\u4e2d\u7684(+)-Stephacidin A\u3001(\u2013)-Notoamide A\u548c\u672c\u6587\u7684\u4e3b\u89d2(+)-Brevianamide A\u53ca(+)-Brevianamide B\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u56fe1. [2,2,2]\u53cc\u73af\u91cd\u6c2e\u8f9b\u70f7\u7c7b\u751f\u7269\u78b1\u7ed3\u6784. \u56fe\u7247\u6765\u6e90\uff1aNature Chemistry<\/em><\/p>\n

Brevianamide A<\/strong>\u548cB<\/strong>\u6700\u521d\u7531Birch\u548cWright\u4e8e1969\u5e74\u4ecePenicillium brevicompactum<\/em>\u771f\u83cc\u4e2d\u5206\u79bb\u51fa\u6765\uff0c\u7ed3\u6784\u5982\u56fe1c\u6240\u793a\uff0c\u5b83\u4eec\u4e5f\u662f\u7b2c\u4e00\u79cd\u53cc\u73af\u751f\u7269\u78b1\u3002Brevianamide A<\/strong>\u5177\u6709\u6740\u866b\u6d3b\u6027\uff0c\u5982\u8349\u5730\u8d2a\u591c\u86feSpodoptera frugiperda<\/em>\u548c\u70df\u8349\u7eff\u68c9\u94c3\u866bHeliothis virescens.<\/em> Brevianamide A<\/strong>\u662f\u4e3b\u8981\u7684\u975e\u5bf9\u6620\u5f02\u6784\u4f53<\/strong>(d.r. \u227390:10)\u3002<\/p>\n

\u5316\u5b66\u5bb6\u65e9\u5c31\u6ce8\u610f\u5230\u8fd9\u79cd[2,2,2]\u53cc\u73af\u7ed3\u6784\uff0c\u53ef\u4ee5\u901a\u8fc7\u5206\u5b50\u5185\u5f02Dieles-Alder\u73af\u52a0\u6210\u53cd\u5e94\u6784\u5efa\u9aa8\u67b6\u7ed3\u6784\uff0c\u5982\u56fe2\u6240\u793a\uff0c\u8fd9\u4e5f\u662f\u5408\u6210Brevianamide\u9aa8\u67b6\u7684\u5173\u952e\u53cd\u5e94\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u56fe2 Dieles-Alder\u73af\u52a0\u6210\u53cd\u5e94. \u56fe\u7247\u6765\u6e90\uff1aNature Chemistry<\/em><\/p>\n

\u5c3d\u7ba1\u8ddd\u79bb\u53d1\u73b0Brevianamide A\u5df2\u670950\u4f59\u5e74\uff0c\u9664\u5f02\u6784\u4f53B\u88ab\u5408\u6210\u51fa\u6765\u5916\uff0c\u5b83\u7684\u5408\u6210\u4ecd\u662f\u4e2a\u96be\u4ee5\u5b9e\u73b0\u7684\u76ee\u6807\uff0c\u4e3b\u8981\u662f\u7531\u4e8e\u96be\u4ee5\u903e\u8d8a\u7684\u53cd\u5e94\u6027\u548c\u9009\u62e9\u6027\u30021989\u5e74Williams\u7b49\u5148\u9a71\u5960\u5b9a\u4e86Brevianamide A\u7684\u5408\u6210\u7b56\u7565\u3002\u4ee5\u5316\u5408\u72693<\/strong>(+)-deoxybrevianamide E\u6c27\u5316\u4e3a\u975e\u624b\u6027\u7684\u6c2e\u6742\u4e8c\u70ef4<\/strong>\uff0c\u63a5\u7740\u8fdb\u884c\u7acb\u4f53\u9009\u62e9\u6027Diels-Alder\u73af\u52a0\u6210\u53cd\u5e94\u5f97\u5230\u53cc\u73af\u91cd\u6c2e\u8f9b\u70f7\u7c7b\u6d88\u65cb\u6df7\u5408\u72695<\/strong>\u548cent<\/em>–5<\/strong>\uff0c\u4e24\u4e2a\u5f02\u6784\u4f53\u7ecf\u8fc7\uff08R\uff09-\u9009\u62e9\u6027\u5432\u54da\u6c27\u5316\u548c[1,2]-\u70f7\u57fa\u8fc1\u79fb\uff0c\u4e3b\u8981\u7684\u5f02\u6784\u4f535<\/strong>\u751f\u6210Brevianamide A\uff0c\u6b21\u8981\u7684\u5f02\u6784\u4f53ent<\/em>–5<\/strong>\u751f\u6210Brevianamide B\u30021993\u5e74\u53c8\u5f00\u53d1\u4e86\u8def\u7ebf2\uff0c\u4ecd\u7136\u662f\u4ee53<\/strong>(+)-deoxybrevianamide E\u5f00\u59cb\uff0c\u7ecf\u975e\u5bf9\u6620\u9009\u62e9\u6027\u5432\u54da\u6c27\u5316\u5f97\u5230\u7f9f\u57fa\u4f2a\u5432\u54da6<\/strong>\uff0c\u518d\u53d1\u751f\u7acb\u4f53\u9009\u62e9\u6027[1,2]-\u70f7\u57fa\u8fc1\u79fb\u53cd\u5e94\u5f97\u5230\u5432\u54da\u916e7<\/strong>\uff0c\u901a\u8fc7\u6c27\u5316\u548cDieles-Alder\u73af\u52a0\u6210\uff0c\u5f97\u5230Brevianamide\u3002\u5408\u6210\u8def\u7ebf\u5982\u56fe3\u6240\u793a\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u56fe3. Brevianamide\u7684\u5df2\u62a5\u9053\u5408\u6210\u8def\u7ebf. \u56fe\u7247\u6765\u6e90\uff1aNature Chemistry<\/em><\/p>\n

\u6700\u8fd1\u82f1\u56fd\u7231\u4e01\u5821\u5927\u5b66<\/strong>\u7684Andrew L. Lawrence<\/strong>\u7b49\u53e6\u8f9f\u8e4a\u5f84\uff0c\u8bba\u6587\u300aTotal synthesis of brevianamide A\u300b\u53d1\u8868\u5728Nature Chemistry<\/em>\u4e0a\uff0chttps:\/\/doi.org\/10.1038\/s41557-020-0442-3<\/a>\u3002\u4ed6\u4eec\u4ee5\u5929\u7136\u4ea7\u7269(+)-dehydrodeoxybrevianamide E 9<\/strong>\u4e3a\u5173\u952e\u7269\u6599\u8fdb\u884c\u4e86\u751f\u7269\u5408\u6210\uff0c\u5176\u7ed3\u6784\u4e2d\u7684\u54cc\u55ea\u4e8c\u916e\u73af\u5df2\u5904\u4e8e\u6c27\u5316\u4f4d\u3002\u4ee5\u8272\u6c28\u9178\u7532\u916f13<\/strong>\u4e3a\u8d77\u59cb\u7269\u6599\uff0c\u4e0e\u90bb\u82ef\u4e8c\u7532\u9178\u9150\u53cd\u5e94\u5f97\u523014<\/strong>\uff0c\u4e0d\u7ecf\u5206\u79bb\u76f4\u63a5\u548cB-\u5f02\u620a\u4e8c\u70ef\u57fa-9-\u787c\u53cc\u73af[3.3.1]\u58ec\u70f7\u53cd\u5e94\u5f97\u5230\u4e2d\u95f4\u4f5315<\/strong>\uff0c\u4e24\u6b65\u6536\u7387\u4e3a69%\u3002\u5728LiCl\u7684DMF\u6eb6\u6db2\u4e2d\u751f\u6210\u9502\u76d017<\/strong>\uff0c\u4e00\u9505\u6cd5\u4e0e\u8131\u6c22\u812f\u6c28\u9178\u916f\u53cd\u5e94\u5f97\u523019<\/strong>\uff0c\u518d\u5728\u6c28\u6c14\u4e2d\u53cd\u5e94\u4e0d\u4ec5\u8131\u53bb\u4e86\u4fdd\u62a4\u57fa\u8fd8\u81ea\u53d1\u6210\u73af\u5f97\u5230\u5316\u5408\u72699<\/strong>\u3002\u7ecf5\u6b65\u53cd\u5e94\u540e\uff0c\u603b\u6536\u7387\u9ad8\u8fbe34%\u3002\u4f7f\u7528\u4e0d\u540c\u7684\u6c27\u5316\u5242\u5982\u8fc7\u6c27\u5316\u916e\u3001\u6c27\u6c2e\u4e19\u5576\u3001\u5355\u7ebf\u6001\u6c27\u3001\u8fc7\u6c27\u9178\u7b49\u5c069<\/strong>\u7684\u6c27\u5316\u4e3adehydrobrevianamide E 12<\/strong>\u548c\u5bf9\u6620\u5f02\u6784\u4f5320<\/strong>\uff0c\u95f4\u6c2f\u8fc7\u6c27\u82ef\u7532\u9178\u7684\u9009\u62e9\u6027\u6700\u597d\uff08d.r<\/em>. 64:36,\uff09\u3002\u5728\u751f\u7269\u5408\u6210\u9886\u57df\uff0c\u9009\u62e9\u6027\u5432\u54da\u6c27\u5316\u662f\u9ec4\u7d20\u4f9d\u8d56\u6027\u5355\u52a0\u6c27\u9176\u63a7\u5236\u7684\u3002\u8fd9\u4e24\u79cd\u4ea7\u7269\uff0c\u6b63\u597d\u53ef\u4ee5\u7528\u6765\u5408\u6210Brevianamide A 1<\/strong>\u548cB 2<\/strong>\u3002\u5316\u5408\u726912<\/strong>\u5728LiOH\u7684\u6c34\u6eb6\u6db2\u4e2d\uff0c\u73af\u5883\u6e29\u5ea6\u4e0b30\u5206\u949f\u5c31\u53ef\u4ee5\u8f6c\u5316\u4e3a1<\/strong>\u548c2<\/strong>\uff0c\u4e24\u4e2a\u4ea7\u7269\u7684\u6536\u7387\u548c\u4e3a63%\u3002\u67f1\u5c42\u6790\u63d0\u7eaf\u540e\u5f97\u5230750mg1<\/strong>\u548c60mg2<\/strong>\uff0c\u624b\u6027\u5206\u6790\u53d1\u73b0\u4e24\u8005\u7684\u5bf9\u6620\u4f53\u6bd4\u4f8b\u90fd\u4e3a93:7\uff0c\u8fd9\u548c\u4ece\u77ed\u5bc6\u9752\u9709\u83ccPenicillium brevicompactum<\/em>\u63d0\u53d6\u7684\u5929\u7136\u4ea7\u7269\u7684\u6570\u503c\u543b\u5408\u3002\u91cd\u7ed3\u6676\u540e1<\/strong>\u7684\u5bf9\u6620\u4f53\u6bd4\u4f8b\u63d0\u9ad8\u81f399:1\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u63a8\u65ad\u8fd9\u4e2aDieles-Alder\u53cd\u5e94\u5e76\u4e0d\u9700\u8981\u9176\u7684\u50ac\u5316\uff0c\u800c\u662f\u81ea\u53d1\u8fdb\u884c\u7684\u3002\u6574\u4e2a\u5408\u6210\u8def\u7ebf\u5982\u4e0b\u56fe4\u6240\u793a\uff1a<\/p>\n

\"\"<\/a><\/p>\n

\u56fe4. Brevianamide\u7684\u5408\u6210\u8def\u7ebf. \u56fe\u7247\u6765\u6e90\uff1aNature Chemistry<\/em><\/p>\n

\u603b\u7ed3\uff1a\u81ea50\u5e74\u524dBirch\u53d1\u73b0Brevianamide A\u4ee5\u6765\uff0c\u5b83\u7684\u5408\u6210\u4e5f\u4ec5\u6709\u51e0\u4e2a\u62a5\u9053\uff0c\u6b64\u6b21\u5408\u6210\u7684\u5173\u952e\u662f\u53d7\u751f\u7269\u5408\u6210\u542f\u53d1\u7684\u4e00\u6b65\u4e32\u8054\u53cd\u5e94\uff0c\u4ece\u5e76\u4e94\u73af\u5316\u5408\u726912<\/strong>\u7ecfDiels-Alder\u73af\u52a0\u6210\u548c[1,2]-\u8fc1\u79fb\u53cd\u5e94\u751f\u6210\u66f4\u590d\u6742\u7684\u516d\u73af\u5316\u5408\u7269Brevianamide A\u3002<\/p>\n

\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u8283\u6d0b\u96ea \u53cc\u73af\u91cd\u6c2e\u8f9b\u70f7\u7c7b[2,2,2]diazaocatne\u751f\u7269\u78b1\u5e7f\u6cdb\u5b58\u5728\u4e8e\u6d77\u6d0b\u751f\u7269\u548c\u771f\u83cc\u4e2d\uff0c\u5177\u6709\u591a\u79cd\u751f\u7269\u6d3b\u6027\u3002\u6839\u636e\u73af\u4e0a\u7684\u6c27\u5316\u7a0b\u5ea6\uff0c\u53ef\u5206\u4e3a\u5355\u6c27\u4ee3\u54cc\u55ea\u578b\uff0c\u5982\u56fe1b\u7684(-)-Paraherquamide\u3001(+)-Malbrancheamide\u3001(+)-Chrysogenamide A;\u53cc\u6c27\u4ee3\u54cc\u55ea\u578b\uff0c\u5982\u56fe1c\u4e2d\u7684(+)-Stephacidin A\u3001(\u2013)-Notoamide A\u548c\u672c\u6587\u7684\u4e3b\u89d2(+)-Brevianamide A\u53ca(+)-Brevianamide B\u3002 \u56fe1. [2,2,2]\u53cc\u73af\u91cd\u6c2e\u8f9b\u70f7\u7c7b\u751f\u7269\u78b1\u7ed3\u6784. \u56fe\u7247\u6765\u6e90\uff1aNature Chemistry Brevianamide A\u548cB\u6700\u521d\u7531Birch\u548cWright\u4e8e1969\u5e74\u4ecePenicillium brevicompactum\u771f\u83cc\u4e2d\u5206\u79bb\u51fa\u6765\uff0c\u7ed3\u6784\u5982\u56fe1c\u6240\u793a\uff0c\u5b83\u4eec\u4e5f\u662f\u7b2c\u4e00\u79cd\u53cc\u73af\u751f\u7269\u78b1\u3002Brevianamide A\u5177\u6709\u6740\u866b\u6d3b\u6027\uff0c\u5982\u8349\u5730\u8d2a\u591c\u86feSpodoptera frugiperda\u548c\u70df\u8349\u7eff\u68c9\u94c3\u866bHeliothis virescens. Brevianamide A\u662f\u4e3b\u8981\u7684\u975e\u5bf9\u6620\u5f02\u6784\u4f53(d.r. \u227390:10)\u3002 \u5316\u5b66\u5bb6\u65e9\u5c31\u6ce8\u610f\u5230\u8fd9\u79cd[2,2,2]\u53cc\u73af\u7ed3\u6784\uff0c\u53ef\u4ee5\u901a\u8fc7\u5206\u5b50\u5185\u5f02Dieles-Alder\u73af\u52a0\u6210\u53cd\u5e94\u6784\u5efa\u9aa8\u67b6\u7ed3\u6784\uff0c\u5982\u56fe2\u6240\u793a\uff0c\u8fd9\u4e5f\u662f\u5408\u6210Brevianamide\u9aa8\u67b6\u7684\u5173\u952e\u53cd\u5e94\u3002 \u56fe2 Dieles-Alder\u73af\u52a0\u6210\u53cd\u5e94. \u56fe\u7247\u6765\u6e90\uff1aNature Chemistry \u5c3d\u7ba1\u8ddd\u79bb\u53d1\u73b0Brevianamide A\u5df2\u670950\u4f59\u5e74\uff0c\u9664\u5f02\u6784\u4f53B\u88ab\u5408\u6210\u51fa\u6765\u5916\uff0c\u5b83\u7684\u5408\u6210\u4ecd\u662f\u4e2a\u96be\u4ee5\u5b9e\u73b0\u7684\u76ee\u6807\uff0c\u4e3b\u8981\u662f\u7531\u4e8e\u96be\u4ee5\u903e\u8d8a\u7684\u53cd\u5e94\u6027\u548c\u9009\u62e9\u6027\u30021989\u5e74Williams\u7b49\u5148\u9a71\u5960\u5b9a\u4e86Brevianamide A\u7684\u5408\u6210\u7b56\u7565\u3002\u4ee5\u5316\u5408\u72693(+)-deoxybrevianamide E\u6c27\u5316\u4e3a\u975e\u624b\u6027\u7684\u6c2e\u6742\u4e8c\u70ef4\uff0c\u63a5\u7740\u8fdb\u884c\u7acb\u4f53\u9009\u62e9\u6027Diels-Alder\u73af\u52a0\u6210\u53cd\u5e94\u5f97\u5230\u53cc\u73af\u91cd\u6c2e\u8f9b\u70f7\u7c7b\u6d88\u65cb\u6df7\u5408\u72695\u548cent–5\uff0c\u4e24\u4e2a\u5f02\u6784\u4f53\u7ecf\u8fc7\uff08R\uff09-\u9009\u62e9\u6027\u5432\u54da\u6c27\u5316\u548c[1,2]-\u70f7\u57fa\u8fc1\u79fb\uff0c\u4e3b\u8981\u7684\u5f02\u6784\u4f535\u751f\u6210Brevianamide A\uff0c\u6b21\u8981\u7684\u5f02\u6784\u4f53ent–5\u751f\u6210Brevianamide B\u30021993\u5e74\u53c8\u5f00\u53d1\u4e86\u8def\u7ebf2\uff0c\u4ecd\u7136\u662f\u4ee53(+)-deoxybrevianamide E\u5f00\u59cb\uff0c\u7ecf\u975e\u5bf9\u6620\u9009\u62e9\u6027\u5432\u54da\u6c27\u5316\u5f97\u5230\u7f9f\u57fa\u4f2a\u5432\u54da6\uff0c\u518d\u53d1\u751f\u7acb\u4f53\u9009\u62e9\u6027[1,2]-\u70f7\u57fa\u8fc1\u79fb\u53cd\u5e94\u5f97\u5230\u5432\u54da\u916e7\uff0c\u901a\u8fc7\u6c27\u5316\u548cDieles-Alder\u73af\u52a0\u6210\uff0c\u5f97\u5230Brevianamide\u3002\u5408\u6210\u8def\u7ebf\u5982\u56fe3\u6240\u793a\u3002 \u56fe3. Brevianamide\u7684\u5df2\u62a5\u9053\u5408\u6210\u8def\u7ebf. \u56fe\u7247\u6765\u6e90\uff1aNature Chemistry \u6700\u8fd1\u82f1\u56fd\u7231\u4e01\u5821\u5927\u5b66\u7684Andrew L. Lawrence\u7b49\u53e6\u8f9f\u8e4a\u5f84\uff0c\u8bba\u6587\u300aTotal synthesis of brevianamide A\u300b\u53d1\u8868\u5728Nature Chemistry\u4e0a\uff0chttps:\/\/doi.org\/10.1038\/s41557-020-0442-3\u3002\u4ed6\u4eec\u4ee5\u5929\u7136\u4ea7\u7269(+)-dehydrodeoxybrevianamide E 9\u4e3a\u5173\u952e\u7269\u6599\u8fdb\u884c\u4e86\u751f\u7269\u5408\u6210\uff0c\u5176\u7ed3\u6784\u4e2d\u7684\u54cc\u55ea\u4e8c\u916e\u73af\u5df2\u5904\u4e8e\u6c27\u5316\u4f4d\u3002\u4ee5\u8272\u6c28\u9178\u7532\u916f13\u4e3a\u8d77\u59cb\u7269\u6599\uff0c\u4e0e\u90bb\u82ef\u4e8c\u7532\u9178\u9150\u53cd\u5e94\u5f97\u523014\uff0c\u4e0d\u7ecf\u5206\u79bb\u76f4\u63a5\u548cB-\u5f02\u620a\u4e8c\u70ef\u57fa-9-\u787c\u53cc\u73af[3.3.1]\u58ec\u70f7\u53cd\u5e94\u5f97\u5230\u4e2d\u95f4\u4f5315\uff0c\u4e24\u6b65\u6536\u7387\u4e3a69%\u3002\u5728LiCl\u7684DMF\u6eb6\u6db2\u4e2d\u751f\u6210\u9502\u76d017\uff0c\u4e00\u9505\u6cd5\u4e0e\u8131\u6c22\u812f\u6c28\u9178\u916f\u53cd\u5e94\u5f97\u523019\uff0c\u518d\u5728\u6c28\u6c14\u4e2d\u53cd\u5e94\u4e0d\u4ec5\u8131\u53bb\u4e86\u4fdd\u62a4\u57fa\u8fd8\u81ea\u53d1\u6210\u73af\u5f97\u5230\u5316\u5408\u72699\u3002\u7ecf5\u6b65\u53cd\u5e94\u540e\uff0c\u603b\u6536\u7387\u9ad8\u8fbe34%\u3002\u4f7f\u7528\u4e0d\u540c\u7684\u6c27\u5316\u5242\u5982\u8fc7\u6c27\u5316\u916e\u3001\u6c27\u6c2e\u4e19\u5576\u3001\u5355\u7ebf\u6001\u6c27\u3001\u8fc7\u6c27\u9178\u7b49\u5c069\u7684\u6c27\u5316\u4e3adehydrobrevianamide E 12\u548c\u5bf9\u6620\u5f02\u6784\u4f5320\uff0c\u95f4\u6c2f\u8fc7\u6c27\u82ef\u7532\u9178\u7684\u9009\u62e9\u6027\u6700\u597d\uff08d.r. 64:36,\uff09\u3002\u5728\u751f\u7269\u5408\u6210\u9886\u57df\uff0c\u9009\u62e9\u6027\u5432\u54da\u6c27\u5316\u662f\u9ec4\u7d20\u4f9d\u8d56\u6027\u5355\u52a0\u6c27\u9176\u63a7\u5236\u7684\u3002\u8fd9\u4e24\u79cd\u4ea7\u7269\uff0c\u6b63\u597d\u53ef\u4ee5\u7528\u6765\u5408\u6210Brevianamide A 1\u548cB 2\u3002\u5316\u5408\u726912\u5728LiOH\u7684\u6c34\u6eb6\u6db2\u4e2d\uff0c\u73af\u5883\u6e29\u5ea6\u4e0b30\u5206\u949f\u5c31\u53ef\u4ee5\u8f6c\u5316\u4e3a1\u548c2\uff0c\u4e24\u4e2a\u4ea7\u7269\u7684\u6536\u7387\u548c\u4e3a63%\u3002\u67f1\u5c42\u6790\u63d0\u7eaf\u540e\u5f97\u5230750mg1\u548c60mg2\uff0c\u624b\u6027\u5206\u6790\u53d1\u73b0\u4e24\u8005\u7684\u5bf9\u6620\u4f53\u6bd4\u4f8b\u90fd\u4e3a93:7\uff0c\u8fd9\u548c\u4ece\u77ed\u5bc6\u9752\u9709\u83ccPenicillium brevicompactum\u63d0\u53d6\u7684\u5929\u7136\u4ea7\u7269\u7684\u6570\u503c\u543b\u5408\u3002\u91cd\u7ed3\u6676\u540e1\u7684\u5bf9\u6620\u4f53\u6bd4\u4f8b\u63d0\u9ad8\u81f399:1\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u63a8\u65ad\u8fd9\u4e2aDieles-Alder\u53cd\u5e94\u5e76\u4e0d\u9700\u8981\u9176\u7684\u50ac\u5316\uff0c\u800c\u662f\u81ea\u53d1\u8fdb\u884c\u7684\u3002\u6574\u4e2a\u5408\u6210\u8def\u7ebf\u5982\u4e0b\u56fe4\u6240\u793a\uff1a \u56fe4. Brevianamide\u7684\u5408\u6210\u8def\u7ebf. \u56fe\u7247\u6765\u6e90\uff1aNature Chemistry \u603b\u7ed3\uff1a\u81ea50\u5e74\u524dBirch\u53d1\u73b0Brevianamide A\u4ee5\u6765\uff0c\u5b83\u7684\u5408\u6210\u4e5f\u4ec5\u6709\u51e0\u4e2a\u62a5\u9053\uff0c\u6b64\u6b21\u5408\u6210\u7684\u5173\u952e\u662f\u53d7\u751f\u7269\u5408\u6210\u542f\u53d1\u7684\u4e00\u6b65\u4e32\u8054\u53cd\u5e94\uff0c\u4ece\u5e76\u4e94\u73af\u5316\u5408\u726912\u7ecfDiels-Alder\u73af\u52a0\u6210\u548c[1,2]-\u8fc1\u79fb\u53cd\u5e94\u751f\u6210\u66f4\u590d\u6742\u7684\u516d\u73af\u5316\u5408\u7269Brevianamide A\u3002 \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01","protected":false},"author":26,"featured_media":32604,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1271],"tags":[2712,2713,275],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/808fcb54c81a4a5f97f29c321f9f7e5d.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-8mo","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/32140"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=32140"}],"version-history":[{"count":4,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/32140\/revisions"}],"predecessor-version":[{"id":32170,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/32140\/revisions\/32170"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/32604"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=32140"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=32140"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=32140"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}