{"id":32479,"date":"2020-06-12T08:08:08","date_gmt":"2020-06-12T00:08:08","guid":{"rendered":"\/\/www.gsbet888.com\/?p=32479"},"modified":"2020-07-19T11:44:53","modified_gmt":"2020-07-19T03:44:53","slug":"ando%e7%83%af%e5%9f%ba%e5%8c%96","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2020\/06\/ando%e7%83%af%e5%9f%ba%e5%8c%96.html","title":{"rendered":"Ando\u70ef\u57fa\u5316"},"content":{"rendered":"<h4><strong>\u6982\u8981<\/strong><\/h4>\n<p>Ando\u70ef\u57fa\u5316 (Ando olefination) \u53c8\u79f0\u4e3aAndo-Wittig\u53cd\u5e94 (Ando-Wittig reaction), \u00a0\u662f\u5728\u5f3a\u78b1\u6027\u6761\u4ef6\u4e0b(\u5982Triton<sup>\u00ae<\/sup> B (\u6216\u79f0\u4e3aTriton<sup>TM<\/sup> B, Triton B )\u3001\u6c22\u5316\u94a0\u3001\u53d4\u4e01\u9187\u94be\u6216KHMDS)\uff0c\u901a\u8fc7\u4e59\u6c27\u7fb0\u57fa\u7532\u57fa\u4e8c\u82ef\u57fa\u81a6\u9178\u916f\u8bd5\u5242 (\u6587\u732e\u4e2d\u79f0\u4e3aAndo\u8bd5\u5242\u6216Ando\u81a6\u9178\u916f)\u4e0e\u919b\u4f5c\u7528\uff0c\u83b7\u5f97(Z)-\u03b1,\u03b2-\u4e0d\u9971\u548c\u916f\u7684\u53cd\u5e94<sup>[1]<\/sup>\u3002\u8be5\u53cd\u5e94\u57281995\u5e74\u7531\u65e5\u672cRyukyu\u5927\u5b66\u6559\u80b2\u5b66\u9662 (College of \u00a0Education, University of the Ryukyu, \u7409\u7403\u5927\u5b66\u6559\u80b2\u5b66\u90e8)\u7684Ando (Ando Kaori, \u5b89\u85e4 \u9999\u7e54)\u7814\u7a76\u7ec4\u9996\u6b21\u62a5\u9053<sup>[1]<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-33932\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2382c315a6ba396be1932dd8dafaff52-1.jpg\" alt=\"\" width=\"863\" height=\"438\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2382c315a6ba396be1932dd8dafaff52-1.jpg 863w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2382c315a6ba396be1932dd8dafaff52-1-300x152.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2382c315a6ba396be1932dd8dafaff52-1-680x345.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2382c315a6ba396be1932dd8dafaff52-1-768x390.jpg 768w\" sizes=\"(max-width: 863px) 100vw, 863px\" \/>1997\u5e74\uff0cAndo\u7ee7\u7eed\u5bf9\u4e0a\u8ff0\u53cd\u5e94\u8fdb\u884c\u6df1\u5165\u7814\u7a76\uff0c\u5c06\u5e95\u7269\u6269\u5c55\u81f3\u5404\u7c7b\u8102\u80aa\u919b\uff0c\u5e76\u5c06\u6700\u521d\u7684\u4e8c\u82ef\u57fa\u81a6\u9178\u916f\u8bd5\u5242\u6269\u5c55\u81f3\u5404\u79cd\u4e8c\u82b3\u57fa\u81a6\u9178\u916f (diaryl phosphonate)<sup> [2]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/2-49.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32481 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/2-49.jpg\" alt=\"\" width=\"719\" height=\"522\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/2-49.jpg 1228w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/2-49-300x218.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/2-49-680x493.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/2-49-768x557.jpg 768w\" sizes=\"(max-width: 719px) 100vw, 719px\" \/><\/a><\/p>\n<p>\u4e4b\u540e\uff0cJ. Motoyoshiya (Motoyoshiya Jiro, Department of Chemistry, Faculty of Textite Science and Technology, Shinshu University\u672c\u5409\u8c37 \u4e8c\u90ce,\u4fe1\u5dde\u5927\u5b66\u7e4a\u7dad\u5b66\u90e8\u7d20\u6750\u958b\u767a\u5316\u5b66\u79d1)\u53d1\u73b0\u91c7\u7528\u4e8c\u6c1f\u4ee3\u82b3\u57fa\u81a6\u9178\u916f\u8bd5\u5242\uff0c\u540c\u6837\u53ef\u4ee5\u83b7\u5f97\u4f18\u826f\u7684(Z)-\u7acb\u4f53\u9009\u62e9\u6027<sup>[3]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-38.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32482 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-38.jpg\" alt=\"\" width=\"691\" height=\"306\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-38.jpg 1299w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-38-300x133.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-38-680x300.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-38-768x339.jpg 768w\" sizes=\"(max-width: 691px) 100vw, 691px\" \/><\/a><\/p>\n<p>1998\u5e74\uff0cT. Y. <strong>Z<\/strong>hang\u91c7\u7528\u6c30\u7532\u57fa\u4e8c\u82ef\u57fa\u81a6\u9178\u916f\u8bd5\u5242\uff0c\u6210\u529f\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6761\u4ef6\u5e94\u7528\u4e8e(Z)-\u03b1,\u03b2-\u4e0d\u9971\u548c\u8148\u7684\u5408\u6210<sup>[4]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4-30.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32483 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4-30.jpg\" alt=\"\" width=\"679\" height=\"114\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4-30.jpg 994w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4-30-300x50.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4-30-680x114.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4-30-768x129.jpg 768w\" sizes=\"(max-width: 679px) 100vw, 679px\" \/><\/a><\/p>\n<p>\u540c\u65f6\uff0cAndo\u8fdb\u4e00\u6b65\u91c7\u7528\u4e59\u6c27\u7fb0\u57fa\u7532\u57fa\u03b1-\u53d6\u4ee3\u7684\u4e8c\u82b3\u57fa\u81a6\u9178\u916f\u8bd5\u5242\uff0c\u987a\u5229\u5b9e\u73b0\u03b1-\u53d6\u4ee3\u7684(Z)-\u03b1,\u03b2-\u4e0d\u9971\u548c\u916f\u7684\u5408\u6210<sup>[5]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/5-23.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32490 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/5-23.jpg\" alt=\"\" width=\"688\" height=\"339\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/5-23.jpg 1299w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/5-23-300x148.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/5-23-680x335.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/5-23-768x378.jpg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/5-23-550x270.jpg 550w\" sizes=\"(max-width: 688px) 100vw, 688px\" \/><\/a><\/p>\n<p>2000\u5e74\uff0cAndo\u91c7\u7528\u65b0\u53d1\u5c55\u7684DBU\/NaI\u78b1\u4f53\u7cfb\uff0c\u5c06\u5e95\u7269\u8303\u56f4\u6269\u5c55\u81f3\u5404\u79cd\u5bf9\u78b1\u654f\u611f\u7684\u919b\uff0c\u5e76\u83b7\u5f97\u4f18\u826f\u7684\u4ea7\u7387\u4e0e\u7acb\u4f53\u9009\u62e9\u6027<sup>[6]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/6-17.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32484 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/6-17.jpg\" alt=\"\" width=\"672\" height=\"308\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/6-17.jpg 1238w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/6-17-300x137.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/6-17-680x311.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/6-17-768x352.jpg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/6-17-370x170.jpg 370w\" sizes=\"(max-width: 672px) 100vw, 672px\" \/><\/a><\/p>\n<p>2002\u5e74\uff0cS. Kojima (Kojima Satoshi, Department of Chemistry, Faculty of Science, Hiroshima University, \u5c0f\u5cf6\u3000\u8061\u5fd7, \u5e83\u5cf6\u5927\u5b66\u7406\u5b66\u90e8\u5316\u5b66\u79d1)\u8fdb\u4e00\u6b65\u5c06Ando\u8bd5\u5242\u5e94\u7528\u4e8e(Z)-\u03b1,\u03b2-\u4e0d\u9971\u548c\u9170\u80fa\u7684\u5408\u6210<sup>[7]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/7-11.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32485 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/7-11.jpg\" alt=\"\" width=\"598\" height=\"130\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/7-11.jpg 961w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/7-11-300x65.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/7-11-680x148.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/7-11-768x167.jpg 768w\" sizes=\"(max-width: 598px) 100vw, 598px\" \/><\/a><\/p>\n<p>2003\u5e74\uff0cP. M. Pihko\u7814\u7a76\u5ba4\u53d1\u73b0\u91c7\u7528NaH\/NaI\u4f53\u7cfb, \u53ef\u4ee5\u66f4\u597d\u5730\u9002\u7528\u4e8e\u5404\u7c7b\u5bf9\u78b1\u654f\u611f\u7684\u919b\uff0c\u5e76\u83b7\u5f97\u4f18\u826f\u7684\u4ea7\u7387\u4e0e\u7acb\u4f53\u9009\u62e9\u6027<sup>[8]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/8-8.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32486 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/8-8.jpg\" alt=\"\" width=\"631\" height=\"457\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/8-8.jpg 1142w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/8-8-300x217.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/8-8-680x492.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/8-8-768x556.jpg 768w\" sizes=\"(max-width: 631px) 100vw, 631px\" \/><\/a><\/p>\n<p>\u4e4b\u540e\uff0cF. P. Touchard\u91c7\u7528TMG (tetramethyl guanidine)\/NaI\u78b1\u4f53\u7cfb\uff0c\u5c06Ando\u8bd5\u5242\u8fdb\u4e00\u6b65\u6269\u5c55\u81f3\u8054\u82b3\u57fa\u81a6\u9178\u916f\uff0c\u5e76\u83b7\u5f97\u4f18\u826f\u7684\u4ea7\u7387\u53ca(Z)-\u9009\u62e9\u6027<sup>[9]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/9-8.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32487 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/9-8.jpg\" alt=\"\" width=\"707\" height=\"324\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/9-8.jpg 1280w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/9-8-300x137.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/9-8-680x311.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/9-8-768x352.jpg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/9-8-370x170.jpg 370w\" sizes=\"(max-width: 707px) 100vw, 707px\" \/><\/a><\/p>\n<p>2004\u5e74\uff0cR. Br\u00fcckner\u91c7\u7528\u4e00\u6eb4\u53ca\u4e8c\u6eb4\u53d6\u4ee3\u7684Ando\u81a6\u9178\u916f\u53c2\u4e0e\u4e0a\u8ff0\u70ef\u57fa\u5316\u8fc7\u7a0b\u3002\u7136\u800c\uff0c\u610f\u5916\u5730\u53d1\u73b0\u4e0e\u4e0a\u8ff0\u53cd\u5e94\u8fc7\u7a0b\u76f8\u53cd\u7684\u7acb\u4f53\u9009\u62e9\u6027\uff0c\u5e76\u987a\u5229\u83b7\u5f97(E)- \u03b1-\u6eb4\u4ee3\u4e19\u70ef\u9178\u916f\u7c7b\u5316\u5408\u7269<sup>[10]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/10-5.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32488 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/10-5.jpg\" alt=\"\" width=\"698\" height=\"115\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/10-5.jpg 1172w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/10-5-300x49.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/10-5-680x112.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/10-5-768x126.jpg 768w\" sizes=\"(max-width: 698px) 100vw, 698px\" \/><\/a><\/p>\n<p>2010\u5e74\uff0cAndo \u8fdb\u4e00\u6b65\u5c06DBU\/NaI\u78b1\u4f53\u7cfb\u5e94\u7528\u4e8e\u5206\u5b50\u5185\u70ef\u57fa\u5316\u8fc7\u7a0b\uff0c\u987a\u5229\u5b8c\u6210\u5404\u7c7b(Z)-\u03b1,\u03b2-\u4e0d\u9971\u548c\u5927\u73af\u5185\u916f\u9aa8\u67b6\u7684\u6784\u5efa<sup>[16]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/11-6.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32489 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/11-6.jpg\" alt=\"\" width=\"601\" height=\"527\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/11-6.jpg 681w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/11-6-300x263.jpg 300w\" sizes=\"(max-width: 601px) 100vw, 601px\" \/><\/a><\/p>\n<p>Ando\u70ef\u57fa\u5316\u53cd\u5e94\u5177\u6709\u4f18\u826f\u7684\u4ea7\u7387\u3001\u5e7f\u6cdb\u7684\u5e95\u7269\u9002\u7528\u8303\u56f4\u53ca\u4f18\u826f\u7684\u7acb\u4f53\u9009\u62e9\u6027\u3002\u76ee\u524d\uff0c\u8be5\u53cd\u5e94\u5df2\u6210\u4e3a\u5408\u6210(Z)-\u03b1,\u03b2-\u4e0d\u9971\u548c\u5316\u5408\u7269\u7684\u5f3a\u6709\u529b\u7684\u65b9\u6cd5<sup>[11]-[12]<\/sup>\u3002\u540c\u65f6\uff0cAndo\u70ef\u57fa\u5316\u53cd\u5e94\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5404\u7c7b\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u7684\u5173\u952e\u6b65\u9aa4<sup>[13]-[15]<\/sup>\u3002<\/p>\n<h4><strong>\u57fa\u672c\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] K. Ando, Tetrahedron Lett. 1995, 36, 4105. doi: <a href=\"https:\/\/doi.org\/10.1016\/0040-4039(95)00726-S\">10.1016\/0040-4039(95)00726-S<\/a>.<\/li>\n<li>[2] K. Ando, J. Org. Chem. 1997, 62, 1934. doi: <a href=\"https:\/\/doi.org\/10.1021\/jo970057c\">10.1021\/jo970057c<\/a>.<\/li>\n<li>[3] K. Kokin, J. Motoyoshiya, S. Hayashi, H. Aoyama, Synth. Commun. 1997, 27, 2387. doi: <a href=\"https:\/\/doi.org\/10.1080\/00397919708004100\">10.1080\/00397919708004100<\/a><\/li>\n<li>[4] T. Y. Zhang, J. C. O\u02b9Toole, J. M. Dunigan, Tetrahedron Lett. 1998, 39, 1461. doi: <a href=\"https:\/\/doi.org\/10.1016\/S0040-4039(97)10836-X\">10.1016\/S0040-4039(97)10836-X<\/a>.<\/li>\n<li>[5] K. Ando, J. Org. Chem. 1998, 63, 8411. doi: <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jo981337a\">10.1021\/jo981337a.<\/a><\/li>\n<li>[6] K. Ando, T. Oishi, M. Hirama, H. Ohno, T. Ibuka, J. Org. Chem. 2000, 65, 4745. doi: <a href=\"https:\/\/doi.org\/10.1021\/jo000068x\">10.1021\/jo000068x<\/a>.<\/li>\n<li>[7] S. Kojima, T. Hidaka, Y. Ohba, and K. Ohkata, Phosphorus Sulfur Silicon and the Related Elements, 2002, 177, 729. doi: <a href=\"https:\/\/doi.org\/10.1080\/10426500210268\">10.1080\/10426500210268<\/a>.<\/li>\n<li>[8] P. M. Pihko, T. M. Salo, Tetrahedron Lett. 2003, 44, 4361. doi: <a href=\"https:\/\/doi.org\/10.1016\/S0040-4039(03)00935-3\">10.1016\/S0040-4039(03)00935-3<\/a>.<\/li>\n<li>[9] F. P. Touchard, Eur. J. Org. Chem. 2005, 9, 1790. doi: <a href=\"https:\/\/doi.org\/10.1002\/ejoc.200400769\">10.1002\/ejoc.200400769<\/a>.<\/li>\n<li>[10] T. Olpp, R. Br Mckner, Synthesis 2004, 2135. doi: <a href=\"https:\/\/www.thieme-connect.de\/products\/ejournals\/abstract\/10.1055\/s-2004-831166\">\u00a010.1055\/s-2004-831166.<\/a><\/li>\n<li>[11] K. Ando, J. Org. Chem. 1999, 64, 8406. doi: <a href=\"https:\/\/doi.org\/10.1021\/jo9907181\">10.1021\/jo9907181<\/a>.<\/li>\n<li>[12] K. Ando, Synlett, 2001, 1272. doi:<a href=\"https:\/\/www.thieme-connect.de\/products\/ejournals\/abstract\/10.1055\/s-2001-16072\"> 10.1055\/s-2001-16072.<\/a><\/li>\n<li>[13] D. Enders, J. L. Vicario, A. J ob, M. Wolberg, M. M\u00fcller, Chem. Eur. J. 2002, 8, 4272. doi: <a href=\"https:\/\/doi.org\/10.1002\/1521-3765(20020916)8:18%3C4272::AID-CHEM4272%3E3.0.CO;2-K\">10.1002\/1521-3765(20020916)8:18&lt;4272::AID-CHEM4272&gt;3.0.CO;2-K<\/a>.<\/li>\n<li>[14] J. T. Feutrill, M. J. Lilly, M. A. Rizzacasa, Org. Lett. 2002, 4, 525. doi: <a href=\"https:\/\/doi.org\/10.1021\/ol017092x\">10.1021\/ol017092x<\/a>.<\/li>\n<li>[15] H. Masaki, J. Maeyama, K. Kamada, T. Esumi, Y. Iwabuchi, S. Hatakeyama, J. Am. Chem. Soc. 2000, 122, 5216. doi: <a href=\"https:\/\/doi.org\/10.1021\/ja000817s\">10.1021\/ja000817s<\/a>.<\/li>\n<li>[16] K. Ando, K. Narumiya, H. Takada, T. Teruya, Org. Lett. 2010, 12, 1460. doi: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ol100071d\">10.1021\/ol100071d.<\/a><\/li>\n<\/ul>\n<h4><strong>\u53cd\u5e94\u673a\u7406<\/strong><\/h4>\n<p><strong>\u8d1f\u79bb\u5b50\u78b1\u53c2\u4e0e\u7684<\/strong><strong>Ando<\/strong><strong>\u70ef\u57fa\u5316<\/strong><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/12-5.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32491 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/12-5.jpg\" alt=\"\" width=\"641\" height=\"437\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/12-5.jpg 1309w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/12-5-300x204.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/12-5-680x463.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/12-5-768x523.jpg 768w\" sizes=\"(max-width: 641px) 100vw, 641px\" \/><\/a><\/p>\n<p><strong>DBU<\/strong><strong>\u53c2\u4e0e\u7684<\/strong><strong>Ando<\/strong><strong>\u70ef\u57fa\u5316<\/strong><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/13-4.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32492 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/13-4.jpg\" alt=\"\" width=\"687\" height=\"297\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/13-4.jpg 1312w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/13-4-300x129.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/13-4-680x293.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/13-4-768x331.jpg 768w\" sizes=\"(max-width: 687px) 100vw, 687px\" \/><\/a><\/p>\n<p><strong>TMG<\/strong><strong>\u53c2\u4e0e\u7684<\/strong><strong>Ando<\/strong><strong>\u70ef\u57fa\u5316\uff1a\u91c7\u53d6\u4e0e<\/strong><strong>DBU<\/strong><strong>\u4fc3\u8fdb\u7684\u70ef\u57fa\u5316\u53cd\u5e94\u76f8\u540c\u7684\u673a\u7406\u3002<\/strong><\/p>\n<p><strong>\u4e00\u6eb4\u53ca\u4e8c\u6eb4\u53d6\u4ee3\u7684<\/strong><strong>Ando<\/strong><strong>\u81a6\u9178\u916f\u53c2\u4e0e\u7684<\/strong><strong>Ando<\/strong><strong>\u70ef\u57fa\u5316<\/strong><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/14-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32493 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/14-1.jpg\" alt=\"\" width=\"769\" height=\"204\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/14-1.jpg 1303w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/14-1-300x80.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/14-1-680x181.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/14-1-768x204.jpg 768w\" sizes=\"(max-width: 769px) 100vw, 769px\" \/><\/a><\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] K. Kokin, K. Iitake, Y. Takaguchi, H. Aoyama, S. Hayashi, J. Motoyoshiya, Phosphorus, Sulfur Silicon and the Related Elements, 1998, 133, 21. doi: <a href=\"https:\/\/doi.org\/10.1080\/10426509808032451\">10.1080\/10426509808032451<\/a>.<\/li>\n<li>[2] K. Ando, J. Org. Chem. 1997, 62, 1934. doi: <a href=\"https:\/\/doi.org\/10.1021\/jo970057c\">10.1021\/jo970057c<\/a>.<\/li>\n<li>[3] K. Ando, J. Org. Chem. 1998, 63, 8411. doi: <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jo981337a\">10.1021\/jo981337a.<\/a><\/li>\n<li>[4] K. Ando, T. Oishi, M. Hirama, H. Ohno, T. Ibuka, J. Org. Chem. 2000, 65, 4745. doi: <a href=\"https:\/\/doi.org\/10.1021\/jo000068x\">10.1021\/jo000068x<\/a>.<\/li>\n<\/ul>\n<h4><strong>\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/h4>\n<p>(Z)-\u03b1,\u03b2-\u4e0d\u9971\u548c\u916f\u7684\u5408\u6210<sup>[1]-[2]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/15-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32494 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/15-1.jpg\" alt=\"\" width=\"641\" height=\"318\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/15-1.jpg 1035w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/15-1-300x149.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/15-1-680x337.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/15-1-768x381.jpg 768w\" sizes=\"(max-width: 641px) 100vw, 641px\" \/><\/a><\/p>\n<p>(+)-Crocacin D\u7684\u5168\u5408\u6210<sup>[3]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/16.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32495 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/16.jpg\" alt=\"\" width=\"631\" height=\"232\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/16.jpg 1139w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/16-300x110.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/16-680x250.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/16-768x282.jpg 768w\" sizes=\"(max-width: 631px) 100vw, 631px\" \/><\/a><\/p>\n<p>(-)-Dysiherbaine\u7684\u5168\u5408\u6210<sup>[4]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/17.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32496 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/17.jpg\" alt=\"\" width=\"698\" height=\"266\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/17.jpg 1332w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/17-300x114.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/17-680x259.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/17-768x292.jpg 768w\" sizes=\"(max-width: 698px) 100vw, 698px\" \/><\/a><\/p>\n<p>(Z)-\u03b1,\u03b2-\u4e0d\u9971\u548c\u9170\u80fa\u7684\u5408\u6210<sup>[5]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/18.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32497 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/18.jpg\" alt=\"\" width=\"628\" height=\"319\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/18.jpg 1098w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/18-300x152.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/18-680x346.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/18-768x390.jpg 768w\" sizes=\"(max-width: 628px) 100vw, 628px\" \/><\/a><\/p>\n<h4><strong>\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/h4>\n<p><span style=\"color: #0000ff\"><strong>Triton\u00ae B<\/strong><strong>\u6216\u6c22\u5316\u94a0\u53c2\u4e0e\u7684<\/strong><strong>Ando<\/strong><strong>\u70ef\u57fa\u5316<\/strong><\/span><\/p>\n<p>\u5728-78 \u00b0C\uff0c\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u5c06\u82b3\u57fa\u81a6\u9178\u916f (1 eq. )\u6eb6\u4e8e\u65e0\u6c34THF (\u6d53\u5ea6\u4e3a0.05 M)\uff0c\u52a0\u5165\u78b1 (Triton<sup>\u00ae<\/sup> B, NaH)\u4e4b\u540e\uff0c\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u6405\u62cc15 min-1h (\u53d6\u51b3\u4e8e\u4e0d\u540c\u7ed3\u6784\u7684\u82b3\u57fa\u81a6\u9178\u916f)\u3002\u968f\u540e\uff0c\u518d\u52a0\u5165\u919b (1.1 eq.)\u3002\u4e4b\u540e\uff0c\u57281-2 h\u4e4b\u5185\uff0c\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u9010\u6e10\u5347\u81f3\u6240\u9700\u6e29\u5ea6\u3002\u7ee7\u7eed\u6405\u62cc\uff0c\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u52a0\u5165\u9971\u548c\u6c2f\u5316\u94f5\u6eb6\u6db2\u6dec\u706d\u53cd\u5e94\u3002\u6dec\u706d\u5b8c\u6210\u540e\uff0c\u52a0\u5165\u4e59\u9178\u4e59\u916f\u8fdb\u884c\u8403\u53d6\u3002\u5c06\u5408\u5e76\u7684\u6709\u673a\u76f8\u4f9d\u6b21\u901a\u8fc7\u6c34\u53ca\u9971\u548c\u98df\u76d0\u6c34\u8fdb\u884c\u6d17\u6da4\uff0c\u518d\u901a\u8fc7\u65e0\u6c34\u786b\u9178\u9541\u5e72\u71e5\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u3002\u5c06\u6b8b\u4f59\u7269\u901a\u8fc7\u7845\u80f6\u67f1\u8272\u8c31\u5206\u79bb\u7eaf\u5316\u540e\uff0c\u83b7\u5f97\u76f8\u5e94\u70ef\u57fa\u5316\u4ea7\u7269\u3002<\/p>\n<p><span style=\"color: #0000ff\"><strong>KHMDS<\/strong><strong>\u53c2\u4e0e\u7684<\/strong><strong>Ando<\/strong><strong>\u70ef\u57fa\u5316<\/strong><\/span><\/p>\n<p>\u5728-78 \u00b0C\uff0c\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u5c06KHMDS (0.5 M \u7532\u82ef\u6eb6\u6db2, 1 eq.)\u6ef4\u52a0\u81f3\u542b\u670918-\u51a0-6 (5 eq.)\u7684\u82b3\u57fa\u81a6\u9178\u916f (1 eq. )\u7684\u65e0\u6c34THF\u6eb6\u6db2 (\u6d53\u5ea6\u4e3a0.05 M)\u4e2d\u3002\u4e4b\u540e\uff0c\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u6405\u62cc1h\u540e\uff0c\u518d\u52a0\u5165\u919b(1.1 eq.)\u7684\u65e0\u6c34THF\u6eb6\u6db2 (\u5e95\u7269\u6d53\u5ea6\u4e3a0.5 M)\u3002\u7ee7\u7eed\u6405\u62cc\uff0c\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u53cd\u5e94\u6df7\u5408\u7269\u5347\u81f3\u5ba4\u6e29\uff0c\u518d\u52a0\u5165\u9971\u548c\u6c2f\u5316\u94f5\u6eb6\u6db2\u6dec\u706d\u53cd\u5e94\u3002\u6dec\u706d\u5b8c\u6210\u540e\uff0c\u52a0\u5165\u4e59\u919a\u8fdb\u884c\u8403\u53d6\u3002\u5c06\u5408\u5e76\u7684\u6709\u673a\u76f8\u4f9d\u6b21\u901a\u8fc7\u6c34\u53ca\u9971\u548c\u98df\u76d0\u6c34\u6d17\u6da4\uff0c\u518d\u901a\u8fc7\u65e0\u6c34\u786b\u9178\u94a0\u5e72\u71e5\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u3002\u5c06\u6b8b\u4f59\u7269\u901a\u8fc7\u7845\u80f6\u67f1\u8272\u8c31\u5206\u79bb\u7eaf\u5316 (\u82ef\u4f5c\u4e3a\u6d17\u8131\u5242)\u540e\uff0c\u83b7\u5f97\u76f8\u5e94\u70ef\u57fa\u5316\u4ea7\u7269\u3002<\/p>\n<p><span style=\"color: #0000ff\"><strong>\u53d4\u4e01\u9187\u94be\u53c2\u4e0e\u7684<\/strong><strong>Ando<\/strong><strong>\u70ef\u57fa\u5316<\/strong><\/span><\/p>\n<p>\u5728-78 \u00b0C\uff0c\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u5c06t-BuOK (1 M THF\u6eb6\u6db2, 1 eq.)\u6ef4\u52a0\u81f3\u82b3\u57fa\u81a6\u9178\u916f (1 eq. )\u7684\u65e0\u6c34THF\u6eb6\u6db2 (\u6d53\u5ea6\u4e3a0.05 M)\u4e2d\u3002\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u6405\u62cc30 min\u540e\uff0c\u518d\u5347\u6e29\u81f3-65 \u00b0C\uff0c\u968f\u540e\uff0c\u52a0\u5165\u919b (1.eq. )\u3002\u5bf9\u4e8e\u56fa\u4f53\u919b\uff0c\u53ef\u4ee5\u901a\u8fc7\u65e0\u6c34THF (\u7ef4\u6301\u5e95\u7269\u6d53\u5ea6\u4e3a0.5 M)\u6eb6\u89e3\u540e\uff0c\u91c7\u7528\u6ce8\u5c04\u5668\u8fdb\u884c\u6ef4\u52a0\u3002\u518d\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u5728-78 \u00b0C\u4e0b\u6405\u62cc10 min\u540e\uff0c\u5347\u81f3\u6240\u9700\u6e29\u5ea6\uff0c\u7ee7\u7eed\u6405\u62cc\uff0c\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u53cd\u5e94\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\uff0c\u52a0\u5165\u9971\u548c\u6c2f\u5316\u94f5\u6eb6\u6db2\u6dec\u706d\u53cd\u5e94\u3002\u6dec\u706d\u5b8c\u6210\u540e\uff0c\u52a0\u5165\u4e59\u919a\u8fdb\u884c\u8403\u53d6\u3002\u5c06\u5408\u5e76\u7684\u6709\u673a\u76f8\u4f9d\u6b21\u901a\u8fc7\u6c34\u53ca\u9971\u548c\u98df\u76d0\u6c34\u6d17\u6da4\uff0c\u518d\u901a\u8fc7\u65e0\u6c34\u786b\u9178\u94a0\u5e72\u71e5\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u3002\u5c06\u6b8b\u4f59\u7269\u901a\u8fc7\u7845\u80f6\u67f1\u8272\u8c31\u6216\u901a\u8fc7\u91cd\u7ed3\u6676\u7eaf\u5316\u540e\uff0c\u83b7\u5f97\u76f8\u5e94\u70ef\u57fa\u5316\u4ea7\u7269\u3002<\/p>\n<p><span style=\"color: #0000ff\"><strong>\u6b63\u4e01\u57fa\u9502\u53c2\u4e0e\u7684<\/strong><strong>Ando<\/strong><strong>\u70ef\u57fa\u5316<\/strong><\/span><\/p>\n<p>\u57280 \u00b0C\uff0c\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u5411\u82b3\u57fa\u81a6\u9178\u916f (1 eq. )\u7684\u65e0\u6c34\u7532\u82ef\u6eb6\u6db2 (\u6d53\u5ea6\u4e3a0.05 M)\u4e2d\u52a0\u5165\u6eb4\u5316\u9502(3.3 eq. )\u540e\uff0c\u518d\u6ef4\u52a0\u6b63\u4e01\u57fa\u9502 (1 M THF\u6eb6\u6db2, 1.4 eq.)\u3002\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u6405\u62cc30 min\u540e\uff0c\u518d\u52a0\u5165\u919b (1.1 eq. )\u3002\u540e\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u57280\u00b0C\u4e0b\u7ee7\u7eed\u6405\u62cc\uff0c\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u53cd\u5e94\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\uff0c\u52a0\u5165\u9971\u548c\u6c2f\u5316\u94f5\u6eb6\u6db2\u6dec\u706d\u53cd\u5e94\u3002\u6dec\u706d\u5b8c\u6210\u540e\uff0c\u52a0\u5165\u4e59\u919a\u8fdb\u884c\u8403\u53d6\u3002\u5c06\u5408\u5e76\u7684\u6709\u673a\u76f8\u4f9d\u6b21\u901a\u8fc7\u6c34\u53ca\u9971\u548c\u98df\u76d0\u6c34\u6d17\u6da4\uff0c\u518d\u901a\u8fc7\u65e0\u6c34\u786b\u9178\u94a0\u5e72\u71e5\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u3002\u5c06\u6b8b\u4f59\u7269\u901a\u8fc7\u7845\u80f6\u67f1\u8272\u8c31\u6216\u901a\u8fc7\u91cd\u7ed3\u6676\u7eaf\u5316\u540e\uff0c\u83b7\u5f97\u76f8\u5e94\u70ef\u57fa\u5316\u4ea7\u7269\u3002<\/p>\n<p><span style=\"color: #0000ff\"><strong>DBU<\/strong><strong>\/<\/strong><strong>\u7898\u5316\u94a0\u7684<\/strong><strong>Ando<\/strong><strong>\u70ef\u57fa\u5316<\/strong><\/span><\/p>\n<p>\u57280 \u00b0C\uff0c\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u5411\u82b3\u57fa\u81a6\u9178\u916f (1 eq. )\u7684\u65e0\u6c34THF\u6eb6\u6db2 (\u6d53\u5ea6\u4e3a0.1 M)\u4e2d\u52a0\u5165\u7898\u5316\u94a0 (1.2 eq.)\u4e0eDBU (1.1 eq.)\u3002\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u6405\u62cc10 min\u540e\uff0c\u518d\u51b7\u5374\u81f3-78\u00b0C\uff0c\u968f\u540e\uff0c\u52a0\u5165\u919b (1.1 eq. )\u3002\u6405\u62cc10 min\u540e\uff0c\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u7f13\u6162\u5347\u6e29\u81f30\u00b0C\uff0c\u7ee7\u7eed\u6405\u62cc\uff0c\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u53cd\u5e94\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\uff0c\u52a0\u5165\u9971\u548c\u6c2f\u5316\u94f5\u6eb6\u6db2\u6dec\u706d\u53cd\u5e94\u3002\u6dec\u706d\u5b8c\u6210\u540e\uff0c\u52a0\u5165\u4e59\u919a\u8fdb\u884c\u8403\u53d6\u3002\u5c06\u5408\u5e76\u7684\u6709\u673a\u76f8\u4f9d\u6b21\u901a\u8fc7\u6c34\u53ca\u9971\u548c\u98df\u76d0\u6c34\u6d17\u6da4\uff0c\u518d\u901a\u8fc7\u65e0\u6c34\u786b\u9178\u94a0\u5e72\u71e5\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\uff0c\u5c06\u6b8b\u4f59\u7269\u901a\u8fc7\u7845\u80f6\u67f1\u8272\u8c31\u6216\u901a\u8fc7\u91cd\u7ed3\u6676\u7eaf\u5316\u540e\uff0c\u83b7\u5f97\u76f8\u5e94\u70ef\u57fa\u5316\u4ea7\u7269\u3002<\/p>\n<p><span style=\"color: #0000ff\"><strong>\u6c22\u5316\u94a0<\/strong><strong>\/<\/strong><strong>\u7898\u5316\u94a0\u53c2\u4e0e\u7684<\/strong><strong>Ando<\/strong><strong>\u70ef\u57fa\u5316<\/strong><\/span><\/p>\n<p>\u57280 \u00b0C\uff0c\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u5411\u82b3\u57fa\u81a6\u9178\u916f (1.3 eq. )\u7684\u65e0\u6c34THF\u6eb6\u6db2 (\u6d53\u5ea6\u4e3a0.11 M)\u4e2d\u52a0\u5165\u7898\u5316\u94a0 (1 eq.)\u3002\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u6405\u62cc5 min\u540e\uff0c\u518d\u52a0\u5165\u6c22\u5316\u94a0(1.3 eq.)\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u51b7\u5374\u81f3-78\u00b0C\u540e\uff0c\u52a0\u5165\u919b (1 eq. )\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u7ef4\u6301-78\u00b0C\uff0c\u7ee7\u7eed\u6405\u62cc\uff0c\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u53cd\u5e94\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\uff0c\u52a0\u5165\u534a\u9971\u548c\u7684\u6c2f\u5316\u94f5\u6eb6\u6db2\u6dec\u706d\u53cd\u5e94\u3002\u6dec\u706d\u5b8c\u6210\u540e\uff0c\u52a0\u5165\u4e59\u919a\u8fdb\u884c\u8403\u53d6\u3002\u5c06\u5408\u5e76\u7684\u6709\u673a\u76f8\u901a\u8fc7\u65e0\u6c34\u786b\u9178\u94a0\u5e72\u71e5\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u3002 \u5c06\u6b8b\u4f59\u7269\u901a\u8fc7\u7845\u80f6\u67f1\u8272\u8c31\u6216\u901a\u8fc7\u91cd\u7ed3\u6676\u7eaf\u5316\u540e\uff0c\u83b7\u5f97\u76f8\u5e94\u70ef\u57fa\u5316\u4ea7\u7269\u3002<\/p>\n<p><span style=\"color: #0000ff\"><strong>NaI\/TMG<\/strong><strong>\u53c2\u4e0e\u7684<\/strong><strong>Ando<\/strong><strong>\u70ef\u57fa\u5316<\/strong><\/span><\/p>\n<p>\u5728\u5ba4\u6e29\uff0c\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u5c06\u82b3\u57fa\u81a6\u9178\u916f (1.1 eq. )\u4e0e\u7898\u5316\u94a0 (1.3 eq.)\u6eb6\u4e8e\u65e0\u6c34THF (\u81a6\u9178\u916f\u6d53\u5ea6\u4e3a0.05 M)\u4e2d\u3002\u518d\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u51b7\u5374\u81f30 \u00b0C\u540e\uff0c\u52a0\u5165TMG (1.2 eq.)\u3002\u6405\u62cc30 min\u540e\uff0c\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u51b7\u5374\u81f3-78\u00b0C\u3002\u6700\u540e\uff0c\u52a0\u5165\u919b (1 eq. )\u3002\u7ef4\u6301-78\u00b0C\uff0c\u7ee7\u7eed\u6405\u62cc\uff0c\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u53cd\u5e94\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\uff0c\u52a0\u5165\u534a\u9971\u548c\u7684\u6c2f\u5316\u94f5\u6eb6\u6db2\u6dec\u706d\u53cd\u5e94\u3002\u6dec\u706d\u5b8c\u6210\u540e\uff0c\u52a0\u5165\u7532\u82ef\u8fdb\u884c\u8403\u53d6\u3002\u5c06\u5408\u5e76\u7684\u6709\u673a\u76f8\u901a\u8fc7\u65e0\u6c34\u786b\u9178\u94a0\u5e72\u71e5\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u3002 \u5c06\u6b8b\u4f59\u7269\u901a\u8fc7\u7845\u80f6\u67f1\u8272\u8c31\u6216\u901a\u8fc7\u91cd\u7ed3\u6676\u7eaf\u5316\u540e\uff0c\u83b7\u5f97\u76f8\u5e94\u70ef\u57fa\u5316\u4ea7\u7269\u3002<\/p>\n<p><span style=\"color: #0000ff\"><strong>\u4e00\u6eb4\u53ca\u4e8c\u6eb4\u53d6\u4ee3\u7684<\/strong><strong>Ando<\/strong><strong>\u81a6\u9178\u916f\u53c2\u4e0e\u7684<\/strong><strong>Ando<\/strong><strong>\u70ef\u57fa\u5316<\/strong><\/span><\/p>\n<p>\u57280 \u00b0C\uff0c\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u5411\u4e00\u6eb4\u53ca\u4e8c\u6eb4\u53d6\u4ee3Ando\u81a6\u9178\u916f (1.1 eq. )\u7684\u65e0\u6c34THF\u6eb6\u6db2 (\u6d53\u5ea6\u4e3a0.5-1g \/mL)\u4e2d\u5206\u6279\u52a0\u5165NaH (1.2 eq.)\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u6405\u62cc10 min\u540e\uff0c\u52a0\u5165\u919b (1 eq. )\u3002\u7ef4\u6301-78\u00b0C\uff0c\u7ee7\u7eed\u6405\u62cc\uff0c\u76f4\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u53cd\u5e94\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\uff0c\u52a0\u5165\u6c34\u8fdb\u884c\u6dec\u706d\u3002\u6dec\u706d\u5b8c\u6210\u540e\uff0c\u518d\u52a0\u5165MTBE\u8403\u53d6\u3002\u5c06\u5408\u5e76\u7684\u6709\u673a\u76f8\u901a\u8fc7\u65e0\u6c34\u786b\u9178\u94a0\u5e72\u71e5\u540e\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u3002\u6b8b\u4f59\u7269\u901a\u8fc7\u7845\u80f6\u67f1\u8272\u8c31\u6216\u901a\u8fc7\u91cd\u7ed3\u6676\u7eaf\u5316\u540e\uff0c\u83b7\u5f97\u76f8\u5e94\u70ef\u57fa\u5316\u4ea7\u7269\u3002<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] K. Ando, J. Org. Chem. 1998, 63, 8411. doi: <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jo981337a\">10.1021\/jo981337a.<\/a><\/li>\n<li>[2] K. Ando, T. Oishi, M. Hirama, H. Ohno , T. Ibuka, J. Org. Chem. 2000, 65, 4745. doi: <a href=\"https:\/\/doi.org\/10.1021\/jo000068x\">10.1021\/jo000068x<\/a>.<\/li>\n<li>[3] J. T. Feutrill, M. J. Lilly, M. A. Rizzacasa, Org. Lett. 2002, 4, 525. doi: <a href=\"https:\/\/doi.org\/10.1021\/ol017092x\">10.1021\/ol017092x<\/a>.<\/li>\n<li>[4] H. Masaki, J. Maeyama, K. Kamada, T. Esumi, Y. Iwabuchi, S. Hatakeyama, J. Am. Chem. Soc. 2000, 122, 5216. doi: <a href=\"https:\/\/doi.org\/10.1021\/ja000817s\">10.1021\/ja000817s<\/a>.<\/li>\n<li>[5] K. Ando, S. Nagaya, Y. Tarumi, Tetrahedron Lett. 2009, 50, 5689. doi: <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0040403909014944?via%3Dihub\">10.1016\/j.tetlet.2009.07.130.<\/a><\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 Ando\u70ef\u57fa\u5316 (Ando olefination) \u53c8\u79f0\u4e3aAndo-Wittig\u53cd\u5e94 (Ando-Wittig reaction), \u00a0\u662f\u5728\u5f3a\u78b1\u6027\u6761\u4ef6\u4e0b(\u5982Triton\u00ae B (\u6216\u79f0\u4e3aTritonTM B, Triton B )\u3001\u6c22\u5316\u94a0\u3001\u53d4\u4e01\u9187\u94be\u6216KHMDS)\uff0c\u901a\u8fc7\u4e59\u6c27\u7fb0\u57fa\u7532\u57fa\u4e8c\u82ef\u57fa\u81a6\u9178\u916f\u8bd5\u5242 (\u6587\u732e\u4e2d\u79f0\u4e3aAndo\u8bd5\u5242\u6216Ando\u81a6\u9178\u916f)\u4e0e\u919b\u4f5c\u7528\uff0c\u83b7\u5f97(Z)-\u03b1,\u03b2-\u4e0d\u9971\u548c\u916f\u7684\u53cd\u5e94[1]\u3002\u8be5\u53cd\u5e94\u57281995\u5e74\u7531\u65e5\u672cRyukyu\u5927\u5b66\u6559\u80b2\u5b66\u9662 (College of \u00a0Education, University of the Ryukyu, \u7409\u7403\u5927\u5b66\u6559\u80b2\u5b66\u90e8)\u7684Ando (Ando Kaori, \u5b89\u85e4 \u9999\u7e54)\u7814\u7a76\u7ec4\u9996\u6b21\u62a5\u9053[1]\u3002 1997\u5e74\uff0cAndo\u7ee7\u7eed\u5bf9\u4e0a\u8ff0\u53cd\u5e94\u8fdb\u884c\u6df1\u5165\u7814\u7a76\uff0c\u5c06\u5e95\u7269\u6269\u5c55\u81f3\u5404\u7c7b\u8102\u80aa\u919b\uff0c\u5e76\u5c06\u6700\u521d\u7684\u4e8c\u82ef\u57fa\u81a6\u9178\u916f\u8bd5\u5242\u6269\u5c55\u81f3\u5404\u79cd\u4e8c\u82b3\u57fa\u81a6\u9178\u916f (diaryl phosphonate) [2]\u3002 \u4e4b\u540e\uff0cJ. Motoyoshiya (Motoyoshiya Jiro, Department of Chemistry, Faculty of Textite Science and Technology, Shinshu University\u672c\u5409\u8c37 \u4e8c\u90ce,\u4fe1\u5dde\u5927\u5b66\u7e4a\u7dad\u5b66\u90e8\u7d20\u6750\u958b\u767a\u5316\u5b66\u79d1)\u53d1\u73b0\u91c7\u7528\u4e8c\u6c1f\u4ee3\u82b3\u57fa\u81a6\u9178\u916f\u8bd5\u5242\uff0c\u540c\u6837\u53ef\u4ee5\u83b7\u5f97\u4f18\u826f\u7684(Z)-\u7acb\u4f53\u9009\u62e9\u6027[3]\u3002 1998\u5e74\uff0cT. Y. Zhang\u91c7\u7528\u6c30\u7532\u57fa\u4e8c\u82ef\u57fa\u81a6\u9178\u916f\u8bd5\u5242\uff0c\u6210\u529f\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6761\u4ef6\u5e94\u7528\u4e8e(Z)-\u03b1,\u03b2-\u4e0d\u9971\u548c\u8148\u7684\u5408\u6210[4]\u3002 \u540c\u65f6\uff0cAndo\u8fdb\u4e00\u6b65\u91c7\u7528\u4e59\u6c27\u7fb0\u57fa\u7532\u57fa\u03b1-\u53d6\u4ee3\u7684\u4e8c\u82b3\u57fa\u81a6\u9178\u916f\u8bd5\u5242\uff0c\u987a\u5229\u5b9e\u73b0\u03b1-\u53d6\u4ee3\u7684(Z)-\u03b1,\u03b2-\u4e0d\u9971\u548c\u916f\u7684\u5408\u6210[5]\u3002 2000\u5e74\uff0cAndo\u91c7\u7528\u65b0\u53d1\u5c55\u7684DBU\/NaI\u78b1\u4f53\u7cfb\uff0c\u5c06\u5e95\u7269\u8303\u56f4\u6269\u5c55\u81f3\u5404\u79cd\u5bf9\u78b1\u654f\u611f\u7684\u919b\uff0c\u5e76\u83b7\u5f97\u4f18\u826f\u7684\u4ea7\u7387\u4e0e\u7acb\u4f53\u9009\u62e9\u6027[6]\u3002 2002\u5e74\uff0cS. Kojima (Kojima Satoshi, Department of Chemistry, Faculty of Science, Hiroshima University, \u5c0f\u5cf6\u3000\u8061\u5fd7, \u5e83\u5cf6\u5927\u5b66\u7406\u5b66\u90e8\u5316\u5b66\u79d1)\u8fdb\u4e00\u6b65\u5c06Ando\u8bd5\u5242\u5e94\u7528\u4e8e(Z)-\u03b1,\u03b2-\u4e0d\u9971\u548c\u9170\u80fa\u7684\u5408\u6210[7]\u3002 2003\u5e74\uff0cP. M. Pihko\u7814\u7a76\u5ba4\u53d1\u73b0\u91c7\u7528NaH\/NaI\u4f53\u7cfb, \u53ef\u4ee5\u66f4\u597d\u5730\u9002\u7528\u4e8e\u5404\u7c7b\u5bf9\u78b1\u654f\u611f\u7684\u919b\uff0c\u5e76\u83b7\u5f97\u4f18\u826f\u7684\u4ea7\u7387\u4e0e\u7acb\u4f53\u9009\u62e9\u6027[8]\u3002 \u4e4b\u540e\uff0cF. P. Touchard\u91c7\u7528TMG (tetramethyl guanidine)\/NaI\u78b1\u4f53\u7cfb\uff0c\u5c06Ando\u8bd5\u5242\u8fdb\u4e00\u6b65\u6269\u5c55\u81f3\u8054\u82b3\u57fa\u81a6\u9178\u916f\uff0c\u5e76\u83b7\u5f97\u4f18\u826f\u7684\u4ea7\u7387\u53ca(Z)-\u9009\u62e9\u6027[9]\u3002 2004\u5e74\uff0cR. Br\u00fcckner\u91c7\u7528\u4e00\u6eb4\u53ca\u4e8c\u6eb4\u53d6\u4ee3\u7684Ando\u81a6\u9178\u916f\u53c2\u4e0e\u4e0a\u8ff0\u70ef\u57fa\u5316\u8fc7\u7a0b\u3002\u7136\u800c\uff0c\u610f\u5916\u5730\u53d1\u73b0\u4e0e\u4e0a\u8ff0\u53cd\u5e94\u8fc7\u7a0b\u76f8\u53cd\u7684\u7acb\u4f53\u9009\u62e9\u6027\uff0c\u5e76\u987a\u5229\u83b7\u5f97(E)- \u03b1-\u6eb4\u4ee3\u4e19\u70ef\u9178\u916f\u7c7b\u5316\u5408\u7269[10]\u3002 2010\u5e74\uff0cAndo \u8fdb\u4e00\u6b65\u5c06DBU\/NaI\u78b1\u4f53\u7cfb\u5e94\u7528\u4e8e\u5206\u5b50\u5185\u70ef\u57fa\u5316\u8fc7\u7a0b\uff0c\u987a\u5229\u5b8c\u6210\u5404\u7c7b(Z)-\u03b1,\u03b2-\u4e0d\u9971\u548c\u5927\u73af\u5185\u916f\u9aa8\u67b6\u7684\u6784\u5efa[16]\u3002 Ando\u70ef\u57fa\u5316\u53cd\u5e94\u5177\u6709\u4f18\u826f\u7684\u4ea7\u7387\u3001\u5e7f\u6cdb\u7684\u5e95\u7269\u9002\u7528\u8303\u56f4\u53ca\u4f18\u826f\u7684\u7acb\u4f53\u9009\u62e9\u6027\u3002\u76ee\u524d\uff0c\u8be5\u53cd\u5e94\u5df2\u6210\u4e3a\u5408\u6210(Z)-\u03b1,\u03b2-\u4e0d\u9971\u548c\u5316\u5408\u7269\u7684\u5f3a\u6709\u529b\u7684\u65b9\u6cd5[11]-[12]\u3002\u540c\u65f6\uff0cAndo\u70ef\u57fa\u5316\u53cd\u5e94\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5404\u7c7b\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u7684\u5173\u952e\u6b65\u9aa4[13]-[15]\u3002 \u57fa\u672c\u6587\u732e [1] K. Ando, Tetrahedron Lett. 1995, 36, 4105. doi: 10.1016\/0040-4039(95)00726-S. [2] K. Ando, J. Org. Chem. 1997, 62, 1934. doi: 10.1021\/jo970057c. [3] K. Kokin, J. Motoyoshiya, S. Hayashi, [&hellip;]","protected":false},"author":21,"featured_media":32498,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2],"tags":[2745,2744,2663],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/b4732b6891c510aeb62c5823b728c019.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-8rR","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/32479"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=32479"}],"version-history":[{"count":3,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/32479\/revisions"}],"predecessor-version":[{"id":33933,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/32479\/revisions\/33933"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/32498"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=32479"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=32479"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=32479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}