{"id":32510,"date":"2020-06-19T09:02:33","date_gmt":"2020-06-19T01:02:33","guid":{"rendered":"\/\/www.gsbet888.com\/?p=32510"},"modified":"2020-06-19T09:02:33","modified_gmt":"2020-06-19T01:02:33","slug":"bc6f53-cpa%e5%82%ac%e5%8c%962-%e8%8a%b3%e5%9f%ba-3h-%e5%90%b2%e5%93%9a-3-%e9%85%ae%e5%92%8c%ce%b1-%e7%94%b2%e5%9f%ba%e8%8b%af%e4%b9%99%e7%83%af%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0%e9%85%ae%e4%ba%9a","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2020\/06\/bc6f53-cpa%e5%82%ac%e5%8c%962-%e8%8a%b3%e5%9f%ba-3h-%e5%90%b2%e5%93%9a-3-%e9%85%ae%e5%92%8c%ce%b1-%e7%94%b2%e5%9f%ba%e8%8b%af%e4%b9%99%e7%83%af%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0%e9%85%ae%e4%ba%9a.html","title":{"rendered":"B(C6F5)3\/CPA\u50ac\u53162-\u82b3\u57fa-3H-\u5432\u54da-3-\u916e\u548c\u03b1-\u7532\u57fa\u82ef\u4e59\u70ef\u7684\u4e0d\u5bf9\u79f0\u916e\u4e9a\u80fa-ene\u53cd\u5e94"},"content":{"rendered":"<p>Ene\u53cd\u5e94\u662f\u5e26\u6709<a href=\"https:\/\/baike.baidu.com\/item\/%E7%83%AF%E4%B8%99%E5%9F%BA\">\u70ef\u4e19\u57fa<\/a>\u6c22\u7684<a href=\"https:\/\/baike.baidu.com\/item\/%E7%83%AF%E7%83%83\/1137869\">\u70ef\u70c3<\/a>\u548c\u4eb2\u70ef\u4f53\u4e4b\u95f4\u53d1\u751f\u7684\u53cd\u5e94\uff0c\u8fd9\u662f\u6700\u76f4\u63a5\u7684\u539f\u5b50\u5229\u7528\u7387\u6700\u9ad8\u7684\u78b3-\u78b3\u952e\u5f62\u6210\u65b9\u6cd5\u3002Br\u00f8nsted\u9178\u548cLewis\u9178\u53ef\u4ee5\u6709\u6548\u5730\u50ac\u5316\u533a\u57df\u9009\u62e9\u6027\u7684\u4e9a\u6c28-ene\u53cd\u5e94\uff0c\u4f46\u5173\u4e8e\u9178\u50ac\u5316\u4e0d\u5bf9\u79f0\u7684\u4e9a\u6c28-ene\u53cd\u5e94\u7684\u62a5\u9053\u8fd8\u5f88\u5c11\u30021998\u5e74\uff0cLectka\u56e2\u961f\u548cJ\u00f8rgensen\u56e2\u961f\u9996\u6b21\u62a5\u9053\u4e86Lewis\u9178CuClO<sub>4<\/sub>-BINAP\u7edc\u5408\u7269\u6216CuPF<sub>6<\/sub>-BINAP\u7edc\u5408\u7269\u5206\u522b\u50ac\u5316\u5bf9\u7532\u82ef\u78fa\u9170\u57fa\u53d6\u4ee3\u7684\u03b1-\u4e9a\u6c28\u916f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u919b\u4e9a\u80fa-ene\u53cd\u5e94<sup>[1]<\/sup>\u3002\u53d7\u5230\u8be5\u62a5\u9053\u7684\u542f\u53d1\uff0c\u919b\u4e9a\u80fa-ene\u53cd\u5e94\u5f97\u5230\u4e86\u6781\u5927\u7684\u53d1\u5c55\uff0c\u800c\u540c\u6837\u91cd\u8981\u7684\u916e\u4e9a\u80fa-ene\u53cd\u5e94\u56e0\u916e\u4e9a\u80fa\u7684\u6d3b\u6027\u4f4e\u3001\u7a7a\u95f4\u4f4d\u963b\u5927\u7b49\u539f\u56e0\u4e00\u76f4\u505c\u6ede\u4e0d\u524d\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5173\u4e8e\u4e0d\u5bf9\u79f0\u916e\u4e9a\u80fa-ene\u53cd\u5e94\u7684\u62a5\u9053\u53ea\u6709Jia\u8bfe\u9898\u7ec4\u62a5\u9053\u7684Ni(ClO<sub>4<\/sub>)<sub>2<\/sub>\u548c\u624b\u6027\u81a6\u7edc\u5408\u7269\u50ac\u5316<em>N<\/em>-\u78fa\u9170\u57fa\u03b1-\u916e\u4e9a\u6c28\u9178\u916f\u548c\u03b1-\u7532\u57fa\u82ef\u4e59\u70ef\u7684\u4e0d\u5bf9\u79f0\u916e\u4e9a\u80fa-ene\u53cd\u5e94\u8fd9\u4e00\u4f8b<sup>[2]<\/sup>\uff08Scheme 1A\uff09\u3002\u53d7\u5230\u8be5\u8bfe\u9898\u7ec4\u62a5\u9053\u7684\u4e0d\u5bf9\u79f0\u916e\u4e9a\u80fa-ene\u53cd\u5e94\u7684\u542f\u53d1\uff0c\u5357\u5f00\u5927\u5b66<a href=\"https:\/\/chem.nankai.edu.cn\/dt.aspx?n=A001012358\">\u674e\u946b\u56e2\u961f<\/a>\u62a5\u9053\u4e86\u7b2c\u4e00\u4f8bB(C<sub>6<\/sub>F<sub>5<\/sub>)<sub>3<\/sub>\/\u624b\u6027\u78f7\u9178\u50ac\u53162-\u82b3\u57fa-3H-\u5432\u54da-3-\u916e\u548c\u03b1-\u7532\u57fa\u82ef\u4e59\u70ef\u7684\u5bf9\u6620\u9009\u62e9\u6027\u916e\u4e9a\u80fa-ene\u53cd\u5e94\uff0c\u80fd\u4ee5\u826f\u597d\u7684\u6536\u7387\u548c\u4f18\u79c0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u4e00\u7cfb\u5217\u91cd\u8981\u7684\u56db\u53d6\u4ee3\u624b\u6027\u5432\u54da-3-\u916e\u884d\u751f\u7269\uff08Scheme 1B\uff09\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e<\/p>\n<blockquote><p>\u201cB(C<sub>6<\/sub>F<sub>5<\/sub>)<sub>3<\/sub>\/Chiral Phosphoric Acid Catalyzed Ketimine-ene Reaction of 2-Aryl-3<em>H<\/em>-indol-3-ones and \u03b1-Methylstyrenes\u201d<\/p>\n<p>Zhang, Q.-X.; Li, Y.; Wang, J.; Yang, C.; Liu, C.-J.; Li, X.;* Cheng, J.-P. <em>Angew. Chem. Int. Ed. <\/em><strong>2020<\/strong>, <em>59<\/em>, 4550-4556. DOI: <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/anie.201915226\">10.1002\/anie.201915226<\/a><\/p><\/blockquote>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/1-53.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32511 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/1-53.jpg\" alt=\"\" width=\"579\" height=\"298\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/1-53.jpg 579w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/1-53-300x154.jpg 300w\" sizes=\"(max-width: 579px) 100vw, 579px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 1. \u4e0d\u5bf9\u79f0\u916e\u4e9a\u80fa-ene\u53cd\u5e94<\/p>\n<h4><strong>\u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd<\/strong><\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/2-51.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32512 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/2-51.jpg\" alt=\"\" width=\"134\" height=\"179\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u674e\u946b\u6559\u6388<\/p>\n<p style=\"text-align: left;\"><span style=\"color: #0000ff;\"><strong>\u7814\u7a76\u7ecf\u5386<\/strong><\/span><\/p>\n<ul>\n<li>1998-2002 \u5357\u5f00\u5927\u5b66\u5316\u5b66\u5b66\u9662\u672c\u79d1 \u5bfc\u5e08\uff1a\u7a0b\u6d25\u57f9 \u9662\u58eb<\/li>\n<li>2002-2007 \u5357\u5f00\u5927\u5b66\u5316\u5b66\u5b66\u9662\u76f4\u653b\u535a \u5bfc\u5e08\uff1a\u7a0b\u6d25\u57f9 \u9662\u58eb<\/li>\n<li>2007-2009 \u4e2d\u56fd\u79d1\u5b66\u9662\u5316\u5b66\u7814\u7a76\u6240\u535a\u58eb\u540e \u5408\u4f5c\u5bfc\u5e08\uff1a\u7f57\u4e09\u4e2d \u7814\u7a76\u5458<\/li>\n<li>2009-2010 \u4e2d\u56fd\u79d1\u5b66\u9662\u5316\u5b66\u7814\u7a76\u6240 \u526f\u7814\u7a76\u5458<\/li>\n<li>2010-2017 \u5357\u5f00\u5927\u5b66\u5316\u5b66\u5b66\u9662 \u526f\u6559\u6388<\/li>\n<li>2018-\u81f3\u4eca \u5357\u5f00\u5927\u5b66\u5316\u5b66\u5b66\u9662 \u6559\u6388<\/li>\n<\/ul>\n<p><strong><span style=\"color: #0000ff;\">\u7814\u7a76\u9886\u57df<\/span><\/strong><\/p>\n<p>\u7269\u7406\u6709\u673a\u5316\u5b66\u5728\u4e0d\u5bf9\u79f0\u50ac\u5316\u53cd\u5e94\u673a\u7406\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u3001\u65b0\u578b\u624b\u6027\u8d28\u5b50\u9178\u50ac\u5316\u5242\u8bbe\u8ba1\u53ca\u5e94\u7528\u3001\u542b\u6709\u624b\u6027\u5b63\u78b3\u4e2d\u5fc3\u5316\u5408\u7269\u7684\u4e0d\u5bf9\u79f0\u5408\u6210\u7b49\u3002<\/p>\n<h4><strong>\u8bba\u6587\u6982\u8981<\/strong><\/h4>\n<p>\u4ee52-\u82ef\u57fa-3<em>H<\/em>-\u5432\u54da-3-\u916e<strong>1a<\/strong>\u548c\u03b1-\u7532\u57fa\u82ef\u4e59\u70ef<strong>2a <\/strong>\u4e3a\u6a21\u677f\u5e95\u7269\uff0c\u4f5c\u8005\u5bf9\u5404\u79cd\u53cd\u5e94\u6761\u4ef6\u8fdb\u884c\u53cd\u590d\u7b5b\u9009\uff0c\u786e\u5b9a\u6700\u4f73\u6761\u4ef6\u4e3a(Table 1)\uff1a2 mol\uff05B(C<sub>6<\/sub>F<sub>5<\/sub>)<sub>3<\/sub>\u548c2 mol\uff05<em>(S)<\/em>&#8211;<strong>4f<\/strong>\u4e3a\u50ac\u5316\u5242\uff0c5\u00c5\u5206\u5b50\u7b5b\u4e3a\u6dfb\u52a0\u7269\uff0c\u4e59\u919a\u4e3a\u6eb6\u5242\uff0c\u5728\u5ba4\u6e29\u6761\u4ef6\u4e0b\u53cd\u5e945 h\uff0c\u80fd\u4ee589%\u7684\u6536\u7387\u548c97%\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269<strong>3a<\/strong>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-40.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32513 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-40.jpg\" alt=\"\" width=\"484\" height=\"590\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-40.jpg 484w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-40-246x300.jpg 246w\" sizes=\"(max-width: 484px) 100vw, 484px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Table 1. \u6761\u4ef6\u7b5b\u9009<\/p>\n<p>\u5728\u6700\u4f18\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf92-\u82b3\u57fa-3<em>H<\/em>-\u5432\u54da-3-\u916e\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u4e86\u8003\u5bdf\u3002\u5404\u79cdC5\u4f4d\u548cC2\u4f4d\u53d6\u4ee3\u76842-\u82b3\u57fa-3<em>H<\/em>-\u5432\u54da-3-\u916e\u5747\u80fd\u8f83\u597d\u7684\u9002\u5e94\u53cd\u5e94\u6761\u4ef6\uff0c\u80fd\u4ee5\u826f\u597d\u81f3\u4f18\u79c0\u7684\u6536\u7387\u548c\u4f18\u79c0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u4e00\u7cfb\u52173,3-\u4e8c\u53d6\u4ee3\u5432\u54da\u916e\u5316\u5408\u7269\u3002\u968f\u540e\uff0c\u4f5c\u8005\u8003\u5bdf\u4e86\u70ef\u70c3\u7684\u5e95\u7269\u8303\u56f4\u3002\u5404\u79cd\u90bb\u3001\u95f4\u3001\u5bf9\u4e3a\u53d6\u4ee3\u7684\u03b1-\u7532\u57fa\u82ef\u4e59\u70ef\u4ee5\u53ca\u73af\u72b6\u70ef\u70c3\u5747\u80fd\u4e0e2-\u82ef\u57fa-3<em>H<\/em>-\u5432\u54da-3-\u916e\u53cd\u5e94\uff0c\u80fd\u4ee5\u4f18\u79c0\u7684\u6536\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u4e00\u7cfb\u5217\u76f8\u5e94\u4ea7\u7269\u3002<\/p>\n<p>\u4e3a\u4e86\u8bc1\u660e\u53cd\u5e94\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u4f5c\u8005\u53c8\u8fdb\u884c\u6269\u5927\u5316\u53cd\u5e94\u548c\u4e00\u7cfb\u5217\u884d\u751f\u53cd\u5e94\uff08Scheme 2\uff09\u3002\u5c06\u53cd\u5e94\u6269\u5927\u81f33.4mmol\uff0c\u53cd\u5e94\u4ea7\u7269\u7684\u6536\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u4e0e\u6a21\u677f\u53cd\u5e94\u4fdd\u6301\u4e00\u81f4\u3002\u901a\u8fc7\u7b80\u5355\u7684\u884d\u751f\u53cd\u5e94\uff0c\u4f5c\u8005\u53ef\u5c06<strong>3a<\/strong>\u8f6c\u5316\u4e3aN-\u70ef\u4e19\u57fa\u5316\u4ea7\u7269<strong>4<\/strong>\u3002\u7136\u540e\uff0c\u5728Grubbs II\u50ac\u5316\u4f5c\u7528\u4e0b\uff0c<strong>4<\/strong>\u53c8\u53ef\u53d1\u751f\u5173\u73af\u53cd\u5e94\u751f\u6210\u591a\u73af\u4e9a\u80fa<strong>5<\/strong>\u3002\u540c\u65f6\uff0c\u5728\u6c27\u5316\u6761\u4ef6\u4e0b\uff0c<strong>4<\/strong>\u53ef\u8f6c\u5316\u4e3a\u5316\u5408\u7269<strong>6<\/strong>\u3002<\/p>\n<p>\u63a5\u7740\uff0c\u4f5c\u8005\u901a\u8fc7\u7406\u8bba\u8ba1\u7b97\u9610\u660e\u4e86B(C<sub>6<\/sub>F<sub>5<\/sub>)<sub>3<\/sub>\u5728\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528\u5373\u80fd\u589e\u5f3a\u78f7\u9178\u7684\u9178\u5ea6\u3001\u6709\u52a9\u4e8e\u7a33\u5b9a\u8fc7\u6e21\u6001\u4ee5\u53ca\u80fd\u901a\u8fc7C\u2013H\u2026F\u6c22\u952e\u76f8\u4e92\u4f5c\u7528\u6539\u53d8\u624b\u6027\u63a7\u5236\u73af\u5883\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4-32.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32514 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4-32.jpg\" alt=\"\" width=\"545\" height=\"416\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4-32.jpg 545w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4-32-300x229.jpg 300w\" sizes=\"(max-width: 545px) 100vw, 545px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 2. \u6269\u5927\u5316\u53cd\u5e94\u548c\u884d\u751f\u53cd\u5e94<\/p>\n<h4><strong>\u8bba\u6587\u603b\u7ed3\u8bc4\u4ef7<\/strong><\/h4>\n<p>\u5357\u5f00\u5927\u5b66\u674e\u946b\u56e2\u961f\u62a5\u9053\u4e86\u7b2c\u4e00\u4f8bB(C<sub>6<\/sub>F<sub>5<\/sub>)<sub>3<\/sub>\/\u624b\u6027\u78f7\u9178\u50ac\u53162-\u82b3\u57fa-3H-\u5432\u54da-3-\u916e\u548c\u03b1-\u7532\u57fa\u82ef\u4e59\u70ef\u7684\u5bf9\u6620\u9009\u62e9\u6027\u916e\u4e9a\u80fa-ene\u53cd\u5e94\uff0c\u80fd\u4ee5\u826f\u597d\u7684\u6536\u7387\u548c\u4f18\u79c0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u4e00\u7cfb\u5217\u91cd\u8981\u7684\u56db\u53d6\u4ee3\u624b\u6027\u5432\u54da-3-\u916e\u884d\u751f\u7269\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u901a\u8fc7\u7406\u8bba\u8ba1\u7b97\u9610\u660e\u4e86B(C<sub>6<\/sub>F<sub>5<\/sub>)<sub>3<\/sub>\u5728\u53cd\u5e94\u4e2d\u53d1\u6325\u7740\u589e\u5f3a\u78f7\u9178\u7684\u9178\u5ea6\u3001\u7a33\u5b9a\u8fc7\u6e21\u6001\u4ee5\u53ca\u901a\u8fc7C\u2013H\u2026F\u6c22\u952e\u76f8\u4e92\u4f5c\u7528\u6539\u53d8\u624b\u6027\u63a7\u5236\u73af\u5883\u7b49\u4f5c\u7528\u3002<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] (a) Drury, W. J.; Ferraris, D.; Cox, C.; Young, B.; Lectka, T. <em> Am. Chem. Soc. <\/em><strong>1998<\/strong>, <em>120<\/em>, 11006-11007; DOI: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja982257r\">10.1021\/ja982257r<\/a> (b) Yao, S.; Fang, X.; J\u00f8rgensen, K. A.<em> Chem. Commun. <\/em><strong>1998<\/strong>, 2547-2548. DOI: <a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/1998\/cc\/a808019d#!divAbstract\">10.1039\/A808019D<\/a><\/li>\n<li>[2] Liu, R.-R. Wang, D.-J. Wu, Xiang, L. B.; Zhang, G.-Q.; Gao, J.-R.; Jia, Y.-X. <em>ACS Catal.<\/em> <strong>2015<\/strong>,<strong> 5<\/strong>, 6524-6528. DOI: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acscatal.5b01793\">1021\/acscatal.5b01793<\/a><\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"Ene\u53cd\u5e94\u662f\u5e26\u6709\u70ef\u4e19\u57fa\u6c22\u7684\u70ef\u70c3\u548c\u4eb2\u70ef\u4f53\u4e4b\u95f4\u53d1\u751f\u7684\u53cd\u5e94\uff0c\u8fd9\u662f\u6700\u76f4\u63a5\u7684\u539f\u5b50\u5229\u7528\u7387\u6700\u9ad8\u7684\u78b3-\u78b3\u952e\u5f62\u6210\u65b9\u6cd5\u3002Br\u00f8nsted\u9178\u548cLewis\u9178\u53ef\u4ee5\u6709\u6548\u5730\u50ac\u5316\u533a\u57df\u9009\u62e9\u6027\u7684\u4e9a\u6c28-ene\u53cd\u5e94\uff0c\u4f46\u5173\u4e8e\u9178\u50ac\u5316\u4e0d\u5bf9\u79f0\u7684\u4e9a\u6c28-ene\u53cd\u5e94\u7684\u62a5\u9053\u8fd8\u5f88\u5c11\u30021998\u5e74\uff0cLectka\u56e2\u961f\u548cJ\u00f8rgensen\u56e2\u961f\u9996\u6b21\u62a5\u9053\u4e86Lewis\u9178CuClO4-BINAP\u7edc\u5408\u7269\u6216CuPF6-BINAP\u7edc\u5408\u7269\u5206\u522b\u50ac\u5316\u5bf9\u7532\u82ef\u78fa\u9170\u57fa\u53d6\u4ee3\u7684\u03b1-\u4e9a\u6c28\u916f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u919b\u4e9a\u80fa-ene\u53cd\u5e94[1]\u3002\u53d7\u5230\u8be5\u62a5\u9053\u7684\u542f\u53d1\uff0c\u919b\u4e9a\u80fa-ene\u53cd\u5e94\u5f97\u5230\u4e86\u6781\u5927\u7684\u53d1\u5c55\uff0c\u800c\u540c\u6837\u91cd\u8981\u7684\u916e\u4e9a\u80fa-ene\u53cd\u5e94\u56e0\u916e\u4e9a\u80fa\u7684\u6d3b\u6027\u4f4e\u3001\u7a7a\u95f4\u4f4d\u963b\u5927\u7b49\u539f\u56e0\u4e00\u76f4\u505c\u6ede\u4e0d\u524d\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5173\u4e8e\u4e0d\u5bf9\u79f0\u916e\u4e9a\u80fa-ene\u53cd\u5e94\u7684\u62a5\u9053\u53ea\u6709Jia\u8bfe\u9898\u7ec4\u62a5\u9053\u7684Ni(ClO4)2\u548c\u624b\u6027\u81a6\u7edc\u5408\u7269\u50ac\u5316N-\u78fa\u9170\u57fa\u03b1-\u916e\u4e9a\u6c28\u9178\u916f\u548c\u03b1-\u7532\u57fa\u82ef\u4e59\u70ef\u7684\u4e0d\u5bf9\u79f0\u916e\u4e9a\u80fa-ene\u53cd\u5e94\u8fd9\u4e00\u4f8b[2]\uff08Scheme 1A\uff09\u3002\u53d7\u5230\u8be5\u8bfe\u9898\u7ec4\u62a5\u9053\u7684\u4e0d\u5bf9\u79f0\u916e\u4e9a\u80fa-ene\u53cd\u5e94\u7684\u542f\u53d1\uff0c\u5357\u5f00\u5927\u5b66\u674e\u946b\u56e2\u961f\u62a5\u9053\u4e86\u7b2c\u4e00\u4f8bB(C6F5)3\/\u624b\u6027\u78f7\u9178\u50ac\u53162-\u82b3\u57fa-3H-\u5432\u54da-3-\u916e\u548c\u03b1-\u7532\u57fa\u82ef\u4e59\u70ef\u7684\u5bf9\u6620\u9009\u62e9\u6027\u916e\u4e9a\u80fa-ene\u53cd\u5e94\uff0c\u80fd\u4ee5\u826f\u597d\u7684\u6536\u7387\u548c\u4f18\u79c0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u4e00\u7cfb\u5217\u91cd\u8981\u7684\u56db\u53d6\u4ee3\u624b\u6027\u5432\u54da-3-\u916e\u884d\u751f\u7269\uff08Scheme 1B\uff09\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e \u201cB(C6F5)3\/Chiral Phosphoric Acid Catalyzed Ketimine-ene Reaction of 2-Aryl-3H-indol-3-ones and \u03b1-Methylstyrenes\u201d Zhang, Q.-X.; Li, Y.; Wang, J.; Yang, C.; Liu, C.-J.; Li, X.;* Cheng, J.-P. Angew. Chem. Int. Ed. 2020, 59, 4550-4556. DOI: 10.1002\/anie.201915226 Scheme 1. \u4e0d\u5bf9\u79f0\u916e\u4e9a\u80fa-ene\u53cd\u5e94 \u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd \u674e\u946b\u6559\u6388 \u7814\u7a76\u7ecf\u5386 1998-2002 \u5357\u5f00\u5927\u5b66\u5316\u5b66\u5b66\u9662\u672c\u79d1 \u5bfc\u5e08\uff1a\u7a0b\u6d25\u57f9 \u9662\u58eb 2002-2007 \u5357\u5f00\u5927\u5b66\u5316\u5b66\u5b66\u9662\u76f4\u653b\u535a \u5bfc\u5e08\uff1a\u7a0b\u6d25\u57f9 \u9662\u58eb 2007-2009 \u4e2d\u56fd\u79d1\u5b66\u9662\u5316\u5b66\u7814\u7a76\u6240\u535a\u58eb\u540e \u5408\u4f5c\u5bfc\u5e08\uff1a\u7f57\u4e09\u4e2d \u7814\u7a76\u5458 2009-2010 \u4e2d\u56fd\u79d1\u5b66\u9662\u5316\u5b66\u7814\u7a76\u6240 \u526f\u7814\u7a76\u5458 2010-2017 \u5357\u5f00\u5927\u5b66\u5316\u5b66\u5b66\u9662 \u526f\u6559\u6388 2018-\u81f3\u4eca \u5357\u5f00\u5927\u5b66\u5316\u5b66\u5b66\u9662 \u6559\u6388 \u7814\u7a76\u9886\u57df \u7269\u7406\u6709\u673a\u5316\u5b66\u5728\u4e0d\u5bf9\u79f0\u50ac\u5316\u53cd\u5e94\u673a\u7406\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u3001\u65b0\u578b\u624b\u6027\u8d28\u5b50\u9178\u50ac\u5316\u5242\u8bbe\u8ba1\u53ca\u5e94\u7528\u3001\u542b\u6709\u624b\u6027\u5b63\u78b3\u4e2d\u5fc3\u5316\u5408\u7269\u7684\u4e0d\u5bf9\u79f0\u5408\u6210\u7b49\u3002 \u8bba\u6587\u6982\u8981 \u4ee52-\u82ef\u57fa-3H-\u5432\u54da-3-\u916e1a\u548c\u03b1-\u7532\u57fa\u82ef\u4e59\u70ef2a \u4e3a\u6a21\u677f\u5e95\u7269\uff0c\u4f5c\u8005\u5bf9\u5404\u79cd\u53cd\u5e94\u6761\u4ef6\u8fdb\u884c\u53cd\u590d\u7b5b\u9009\uff0c\u786e\u5b9a\u6700\u4f73\u6761\u4ef6\u4e3a(Table 1)\uff1a2 mol\uff05B(C6F5)3\u548c2 mol\uff05(S)&#8211;4f\u4e3a\u50ac\u5316\u5242\uff0c5\u00c5\u5206\u5b50\u7b5b\u4e3a\u6dfb\u52a0\u7269\uff0c\u4e59\u919a\u4e3a\u6eb6\u5242\uff0c\u5728\u5ba4\u6e29\u6761\u4ef6\u4e0b\u53cd\u5e945 h\uff0c\u80fd\u4ee589%\u7684\u6536\u7387\u548c97%\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u72693a\u3002 Table 1. \u6761\u4ef6\u7b5b\u9009 \u5728\u6700\u4f18\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf92-\u82b3\u57fa-3H-\u5432\u54da-3-\u916e\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u4e86\u8003\u5bdf\u3002\u5404\u79cdC5\u4f4d\u548cC2\u4f4d\u53d6\u4ee3\u76842-\u82b3\u57fa-3H-\u5432\u54da-3-\u916e\u5747\u80fd\u8f83\u597d\u7684\u9002\u5e94\u53cd\u5e94\u6761\u4ef6\uff0c\u80fd\u4ee5\u826f\u597d\u81f3\u4f18\u79c0\u7684\u6536\u7387\u548c\u4f18\u79c0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u4e00\u7cfb\u52173,3-\u4e8c\u53d6\u4ee3\u5432\u54da\u916e\u5316\u5408\u7269\u3002\u968f\u540e\uff0c\u4f5c\u8005\u8003\u5bdf\u4e86\u70ef\u70c3\u7684\u5e95\u7269\u8303\u56f4\u3002\u5404\u79cd\u90bb\u3001\u95f4\u3001\u5bf9\u4e3a\u53d6\u4ee3\u7684\u03b1-\u7532\u57fa\u82ef\u4e59\u70ef\u4ee5\u53ca\u73af\u72b6\u70ef\u70c3\u5747\u80fd\u4e0e2-\u82ef\u57fa-3H-\u5432\u54da-3-\u916e\u53cd\u5e94\uff0c\u80fd\u4ee5\u4f18\u79c0\u7684\u6536\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u4e00\u7cfb\u5217\u76f8\u5e94\u4ea7\u7269\u3002 \u4e3a\u4e86\u8bc1\u660e\u53cd\u5e94\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u4f5c\u8005\u53c8\u8fdb\u884c\u6269\u5927\u5316\u53cd\u5e94\u548c\u4e00\u7cfb\u5217\u884d\u751f\u53cd\u5e94\uff08Scheme 2\uff09\u3002\u5c06\u53cd\u5e94\u6269\u5927\u81f33.4mmol\uff0c\u53cd\u5e94\u4ea7\u7269\u7684\u6536\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u4e0e\u6a21\u677f\u53cd\u5e94\u4fdd\u6301\u4e00\u81f4\u3002\u901a\u8fc7\u7b80\u5355\u7684\u884d\u751f\u53cd\u5e94\uff0c\u4f5c\u8005\u53ef\u5c063a\u8f6c\u5316\u4e3aN-\u70ef\u4e19\u57fa\u5316\u4ea7\u72694\u3002\u7136\u540e\uff0c\u5728Grubbs II\u50ac\u5316\u4f5c\u7528\u4e0b\uff0c4\u53c8\u53ef\u53d1\u751f\u5173\u73af\u53cd\u5e94\u751f\u6210\u591a\u73af\u4e9a\u80fa5\u3002\u540c\u65f6\uff0c\u5728\u6c27\u5316\u6761\u4ef6\u4e0b\uff0c4\u53ef\u8f6c\u5316\u4e3a\u5316\u5408\u72696\u3002 \u63a5\u7740\uff0c\u4f5c\u8005\u901a\u8fc7\u7406\u8bba\u8ba1\u7b97\u9610\u660e\u4e86B(C6F5)3\u5728\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528\u5373\u80fd\u589e\u5f3a\u78f7\u9178\u7684\u9178\u5ea6\u3001\u6709\u52a9\u4e8e\u7a33\u5b9a\u8fc7\u6e21\u6001\u4ee5\u53ca\u80fd\u901a\u8fc7C\u2013H\u2026F\u6c22\u952e\u76f8\u4e92\u4f5c\u7528\u6539\u53d8\u624b\u6027\u63a7\u5236\u73af\u5883\u3002 Scheme 2. \u6269\u5927\u5316\u53cd\u5e94\u548c\u884d\u751f\u53cd\u5e94 \u8bba\u6587\u603b\u7ed3\u8bc4\u4ef7 \u5357\u5f00\u5927\u5b66\u674e\u946b\u56e2\u961f\u62a5\u9053\u4e86\u7b2c\u4e00\u4f8bB(C6F5)3\/\u624b\u6027\u78f7\u9178\u50ac\u53162-\u82b3\u57fa-3H-\u5432\u54da-3-\u916e\u548c\u03b1-\u7532\u57fa\u82ef\u4e59\u70ef\u7684\u5bf9\u6620\u9009\u62e9\u6027\u916e\u4e9a\u80fa-ene\u53cd\u5e94\uff0c\u80fd\u4ee5\u826f\u597d\u7684\u6536\u7387\u548c\u4f18\u79c0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u4e00\u7cfb\u5217\u91cd\u8981\u7684\u56db\u53d6\u4ee3\u624b\u6027\u5432\u54da-3-\u916e\u884d\u751f\u7269\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u901a\u8fc7\u7406\u8bba\u8ba1\u7b97\u9610\u660e\u4e86B(C6F5)3\u5728\u53cd\u5e94\u4e2d\u53d1\u6325\u7740\u589e\u5f3a\u78f7\u9178\u7684\u9178\u5ea6\u3001\u7a33\u5b9a\u8fc7\u6e21\u6001\u4ee5\u53ca\u901a\u8fc7C\u2013H\u2026F\u6c22\u952e\u76f8\u4e92\u4f5c\u7528\u6539\u53d8\u624b\u6027\u63a7\u5236\u73af\u5883\u7b49\u4f5c\u7528\u3002 \u53c2\u8003\u6587\u732e [1] (a) Drury, W. J.; Ferraris, D.; Cox, C.; Young, B.; Lectka, T. Am. Chem. Soc. 1998, 120, 11006-11007; DOI: 10.1021\/ja982257r (b) Yao, S.; [&hellip;]","protected":false},"author":24,"featured_media":32515,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1271],"tags":[2747,2014,699],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/F-44.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-8sm","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/32510"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=32510"}],"version-history":[{"count":4,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/32510\/revisions"}],"predecessor-version":[{"id":32559,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/32510\/revisions\/32559"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/32515"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=32510"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=32510"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=32510"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}