{"id":32519,"date":"2020-06-17T08:22:49","date_gmt":"2020-06-17T00:22:49","guid":{"rendered":"\/\/www.gsbet888.com\/?p=32519"},"modified":"2020-06-17T08:22:49","modified_gmt":"2020-06-17T00:22:49","slug":"%e6%89%8b%e6%80%a7%e7%a3%b7%e9%85%b8%e5%82%ac%e5%8c%96n-%e8%8a%b3%e5%9f%ba%e9%86%8c%e7%b1%bb%e5%8c%96%e5%90%88%e7%89%a9%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0%e5%8d%a4%e5%8c%96%e5%8f%8d%e5%ba%94%e6%9e%84","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2020\/06\/%e6%89%8b%e6%80%a7%e7%a3%b7%e9%85%b8%e5%82%ac%e5%8c%96n-%e8%8a%b3%e5%9f%ba%e9%86%8c%e7%b1%bb%e5%8c%96%e5%90%88%e7%89%a9%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0%e5%8d%a4%e5%8c%96%e5%8f%8d%e5%ba%94%e6%9e%84.html","title":{"rendered":"\u624b\u6027\u78f7\u9178\u50ac\u5316N-\u82b3\u57fa\u918c\u7c7b\u5316\u5408\u7269\u7684\u4e0d\u5bf9\u79f0\u5364\u5316\u53cd\u5e94\u6784\u5efa\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269"},"content":{"rendered":"<p>\u8f74\u624b\u6027\u5316\u5408\u7269\u5e7f\u6cdb\u5b58\u5728\u4e8e\u836f\u7269\u548c\u5929\u7136\u4ea7\u7269\u4e2d\uff0c\u56e0\u800c\uff0c\u8f74\u624b\u6027\u5316\u5408\u7269\u7684\u5408\u6210\u53d7\u5230\u5316\u5b66\u5bb6\u4eec\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u76ee\u524d\u5173\u4e8e\u8054\u82b3\u57fa\u3001\u82ef\u7532\u9170\u80fa\u4ee5\u53ca\u82ef\u80fa\u7c7b\u8f74\u624b\u6027\u5316\u5408\u7269\u7684\u5408\u6210\u5df2\u7ecf\u53d6\u5f97\u4e86\u4e0d\u9519\u7684\u8fdb\u5c55\uff0c\u4f46\u540c\u6837\u91cd\u8981\u7684\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\u7684\u5408\u6210\u88ab\u5f88\u5927\u7a0b\u5ea6\u88ab\u5ffd\u7565\u4e86(Scheme 1A)\u3002Kawabata\u8bfe\u9898\u7ec4<sup>[1]<\/sup>\u6210\u529f\u6784\u5efa\u4e86\u4e00\u7cfb\u5217\u5206\u5b50\u5185\u5177\u6709N-H-N\u6c22\u952e\u7684\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\uff0c\u4f46\u8be5\u7c7b\u5316\u5408\u7269\u5bf9\u5206\u5b50\u5185\u6c22\u952e\u7684\u957f\u5ea6\u6781\u5176\u654f\u611f\uff0c\u82e5\u53bb\u6389\u82b3\u57fa\u4e0a\u7684\u5438\u7535\u5b50\u57fa\uff0c\u76f8\u5e94\u5316\u5408\u7269\u7684\u7acb\u4f53\u5316\u5b66\u7a33\u5b9a\u6027\u5219\u4f1a\u8fc5\u901f\u964d\u4f4e(Scheme 1B)\u3002\u6700\u8fd1\uff0cClayden\u8bfe\u9898\u7ec4<sup>[2]<\/sup>\u6784\u5efa\u4e86\u5206\u5b50\u5185\u65e0\u6c22\u952e\u4f5c\u7528\u7684\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\uff0c\u4f46\u8fd9\u7c7b\u5316\u5408\u7269\u5728\u5ba4\u6e29\u6761\u4ef6\u4e0b\u90fd\u4f1a\u8fc5\u901f\u6d88\u65cb\u5316(Scheme 1B)\u3002\u4e3a\u4e86\u5f00\u53d1\u65b0\u7684\u6709\u6548\u5408\u6210\u7acb\u4f53\u5316\u5b66\u7a33\u5b9a\u7684\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\uff0c\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u5dde\u7acb\u5927\u5b66<a href=\"http:\/\/www.chemistry.sdsu.edu\/faculty\/index.php?name=Gustafson\">Gustafson<\/a>\u8bfe\u9898\u7ec4\u9996\u6b21\u62a5\u9053\u4e86\u624b\u6027\u78f7\u9178\u50ac\u5316<em>N<\/em>-\u82b3\u57fa\u918c\u7c7b\u5316\u5408\u7269\u7684\u4e0d\u5bf9\u79f0\u5364\u5316\u53cd\u5e94\uff0c\u80fd\u4ee5\u826f\u597d\u81f3\u4f18\u79c0\u7684\u6536\u7387\u548c\u9009\u62e9\u6027\u5f97\u5230\u4e00\u7cfb\u5217\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u53d1\u73b0\u6784\u5efa\u7684\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\u5206\u5b50\u5185\u5b58\u5728N-H-O\u6c22\u952e,\u6240\u4ee5\u8be5\u7c7b\u5316\u5408\u7269\u80fd\u7a33\u5b9a\u5b58\u5728\u3002<\/p>\n<blockquote><p>\u201cCatalytic Atroposelective Synthesis of <em>N<\/em>\u2011Aryl Quinoid Compounds\u201d<\/p>\n<p>Vaidya, S. D.; Toenjes, S. T.; Yamamoto, N.; Maddox, S. M.; Gustafson, J. L.* <em>J. Am. Chem. Soc. <\/em><strong>2020<\/strong>, <em>142<\/em>, 2198-2203. DOI: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.9b12994\">10.1021\/jacs.9b12994<\/a><\/p><\/blockquote>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/1-54.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32520 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/1-54.jpg\" alt=\"\" width=\"565\" height=\"533\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/1-54.jpg 565w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/1-54-300x283.jpg 300w\" sizes=\"(max-width: 565px) 100vw, 565px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 1. \u7814\u7a76\u80cc\u666f<\/p>\n<h4><strong>\u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd<\/strong><\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/2-52.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32521 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/2-52.jpg\" alt=\"\" width=\"262\" height=\"292\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Jeffrey L. Gustafson<\/p>\n<p><strong><span style=\"color: #0000ff;\">\u7814\u7a76\u7ecf\u5386<\/span><\/strong><\/p>\n<ul>\n<li>2006, B.S., Chemistry; San Diego State University;<\/li>\n<li>2011, Ph.D., Organic Chemistry; Yale University;<\/li>\n<li>2011-2013, NIH Postdoctoral Fellow; Yale University.<\/li>\n<\/ul>\n<p><strong><span style=\"color: #0000ff;\">\u7814\u7a76\u5185\u5bb9<\/span><\/strong><\/p>\n<p>(a) The development of chemical methodologies that enable the enantioselective synthesis of complex molecules; (b) The application of these methodologies to access new selective small molecule probes pertaining to aberrant protein phosphorylation; and (c) The design, synthesis and evaluation of small molecule vanadate complexes as phosphatase inhibitors.<\/p>\n<h4><strong>\u8bba\u6587\u6982\u8981<\/strong><\/h4>\n<p>\u4ee5<em>N<\/em>-\u82b3\u57fa\u918c\u7c7b\u5316\u5408\u7269<strong>1a<\/strong>\u548cNBS\u4f5c\u4e3a\u6a21\u677f\u5e95\u7269\uff0c\u4f5c\u8005\u5bf9\u5404\u79cd\u53cd\u5e94\u6761\u4ef6\u8fdb\u884c\u53cd\u590d\u7b5b\u9009\uff0c\u786e\u5b9a\u6700\u4f73\u6761\u4ef6\u4e3a(Table 1)\uff1a10 mol\uff05 <strong>3j<\/strong>\u4e3a\u6700\u4f18\u50ac\u5316\u5242\uff0c\u7532\u82ef\u548c\u6b63\u5df1\u70f7\u7684\u6df7\u5408\u6eb6\u5242\u4e3a\u6700\u4f18\u6eb6\u5242\uff0c4\u00c5\u5206\u5b50\u7b5b\u4e3a\u6dfb\u52a0\u7269\uff0c\u572824<sup>o<\/sup>C\u6761\u4ef6\u4e0b\u53cd\u5e9412 h\uff0c\u80fd\u4ee595%\u7684\u6536\u7387\u548c92\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269<strong>3a<\/strong>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-41.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32522 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-41.jpg\" alt=\"\" width=\"634\" height=\"970\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-41.jpg 772w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-41-196x300.jpg 196w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-41-669x1024.jpg 669w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/3-41-768x1175.jpg 768w\" sizes=\"(max-width: 634px) 100vw, 634px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Table 1. \u6761\u4ef6\u7b5b\u9009<\/p>\n<p>\u5728\u6700\u4f18\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u4e86\u8003\u5bdf\u3002\u5404\u79cd2,4-\u4e8c\u82b3\u57fa\u53d6\u4ee3\u3001\u6742\u73af\u3001\u8418\u6362\u53d6\u4ee3\u30012-\u82b3\u57fa-4-\u6c2f\u53d6\u4ee3\u7684<em>N<\/em>-\u82b3\u57fa\u918c\u5747\u80fd\u8f83\u597d\u7684\u9002\u5e94\u53cd\u5e94\u6761\u4ef6\uff0c\u80fd\u4ee5\u826f\u597d\u81f3\u4f18\u79c0\u7684\u6536\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\u3002\u4f46<em>N<\/em>-\u82b3\u57fa\u918c6\u4f4d\u7684\u53d4\u4e01\u57fa\u6362\u6210\u5f02\u4e19\u57fa\u6216\u4e09\u6c1f\u7532\u57fa\uff0c\u76f8\u5e94\u4ea7\u7269\u7684\u5bf9\u6620\u9009\u62e9\u6027\u660e\u663e\u964d\u4f4e\u3002\u82e5\u5c06NBS\u6362\u6210NCS\u6216NIS\uff0c\u5176\u76f8\u5e94\u4ea7\u7269\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4e5f\u4f1a\u964d\u4f4e\u3002\u540c\u65f6\uff0c\u82e5\u5c06<em>N<\/em>-\u82b3\u57fa\u918c\u4e2d\u7684\u6c2e\u539f\u5b50\u4fdd\u62a4\u4f4f\uff0c\u5219\u53cd\u5e94\u4e0d\u80fd\u6b63\u5e38\u8fdb\u884c\u3002<\/p>\n<p>\u968f\u540e\uff0c\u4e3a\u4e86\u8bc1\u660e\u53cd\u5e94\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u4f5c\u8005\u53c8\u8fdb\u884c\u4e86\u4e00\u7cfb\u5217\u884d\u751f\u53cd\u5e94\u3002<strong>2b<\/strong>\u4e2d\u7684\u6c2e\u5728\u78b1\u6027\u6761\u4ef6\u4e0b\u53ef\u88abTs\u57fa\u56e2\u53d6\u4ee3\uff0c\u80fd\u4ee5\u826f\u597d\u7684\u6536\u7387\u548c\u4f18\u79c0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u5316\u5408\u7269<strong>4<\/strong>\u3002\u540c\u65f6\uff0c<strong>2b<\/strong>\u53d1\u751f\u5076\u8054\u53cd\u5e94\uff0c\u53ef\u4ee5\u4e2d\u7b49\u7684\u6536\u7387\u548c\u4f18\u79c0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u5316\u5408\u7269<strong>5<\/strong>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4-33.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32523 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4-33.jpg\" alt=\"\" width=\"534\" height=\"365\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4-33.jpg 534w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/05\/4-33-300x205.jpg 300w\" sizes=\"(max-width: 534px) 100vw, 534px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 2. \u884d\u751f\u53cd\u5e94<\/p>\n<h4><strong>\u8bba\u6587\u603b\u7ed3\u8bc4\u4ef7<\/strong><\/h4>\n<p>\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u5dde\u7acb\u5927\u5b66<a href=\"http:\/\/www.chemistry.sdsu.edu\/faculty\/index.php?name=Gustafson\">Gustafson<\/a>\u8bfe\u9898\u7ec4\u9996\u6b21\u62a5\u9053\u4e86\u624b\u6027\u78f7\u9178\u50ac\u5316<em>N<\/em>-\u82b3\u57fa\u918c\u7c7b\u5316\u5408\u7269\u7684\u4e0d\u5bf9\u79f0\u5364\u5316\u53cd\u5e94\uff0c\u80fd\u4ee5\u826f\u597d\u81f3\u4f18\u79c0\u7684\u6536\u7387\u548c\u9009\u62e9\u6027\u5f97\u5230\u4e00\u7cfb\u5217\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u53d1\u73b0\u6784\u5efa\u7684\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\u5206\u5b50\u5185\u5b58\u5728N-H-O\u6c22\u952e,\u6240\u4ee5\u8be5\u7c7b\u5316\u5408\u7269\u80fd\u7a33\u5b9a\u5b58\u5728\u3002\u8be5\u7b56\u7565\u4e3a\u9ad8\u6548\u5408\u6210\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u65b9\u6cd5\u3002<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] (a) Kawabata, T.; Jiang, C.; Hayashi, K.; Tsubaki, K.; Yoshimura, T.; Majumdar, S.; Sasamori, T.; Tokitoh, N. <em> Am. Chem. Soc. <\/em><strong>2009<\/strong>, <em>131<\/em>, 54-55. DOI: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja808213r?__cf_chl_captcha_tk__=b41ad3509fd3bc4a3adcc397fd7ce4604873ee6f-1589978920-0-AQHCw_vnKYYDAOJLtCDripwxcX9O8I_K4l8Rdn5XCBxfMtmwUxCDi4cdbHPocipdUXZS7b_D6GxH4y_ejoJN-oEhs4FsXv-KWTzV3NwJoq1h7P9CnLIY8Wr7a-GP1YLHFQZ9_sRRvArtQYJhhKHGCIWDDVl6JmAIdeo2plxGhDtC42vbQq1B_KbdIH_qmyF8GDJGej2UnCtwU7MS9zUlFwXULpYXm2KRLpwRE1mC-6IKPUbrJ1dXGPvzqFL_DfCSjZCP1ocGmCMgulsyhSc_Dzz9P8Y7el5eZ6llq7-qrKbm6twd3rnsIjezxSK6oSn-63wYMhw3Qepj_dQivAmVVDoPnDlZ78ep8ONzlbGpyxleT9VUx2VebnZh-31PqvAbp-4TT6uscWk-SA8ByC_WpZ8\">10.1021\/ja808213r <\/a>(b) Hayashi, K.; Matubayasi, N.; Jiang, C.; Yoshimura, T.; Majumdar, S.; Sasamori, T.; Tokitoh, N.; Kawabata, T. <em>J. Org. Chem.<\/em> <strong>2010<\/strong>, <em>75<\/em>, 5031-5036. DOI: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jo100586b\">10.1021\/jo100586b<\/a><\/li>\n<li>[2] Costil, R.; Dale, H. J. A.; Fey, N.; Whitcombe, G.; Matlock, J. V.; Clayden, J. Angew. Chem., Int. Ed. <strong>2017<\/strong>, <em>56<\/em>, 12533-12537. DOI: <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/anie.201706341\">1002\/anie.201706341<\/a><\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u8f74\u624b\u6027\u5316\u5408\u7269\u5e7f\u6cdb\u5b58\u5728\u4e8e\u836f\u7269\u548c\u5929\u7136\u4ea7\u7269\u4e2d\uff0c\u56e0\u800c\uff0c\u8f74\u624b\u6027\u5316\u5408\u7269\u7684\u5408\u6210\u53d7\u5230\u5316\u5b66\u5bb6\u4eec\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u76ee\u524d\u5173\u4e8e\u8054\u82b3\u57fa\u3001\u82ef\u7532\u9170\u80fa\u4ee5\u53ca\u82ef\u80fa\u7c7b\u8f74\u624b\u6027\u5316\u5408\u7269\u7684\u5408\u6210\u5df2\u7ecf\u53d6\u5f97\u4e86\u4e0d\u9519\u7684\u8fdb\u5c55\uff0c\u4f46\u540c\u6837\u91cd\u8981\u7684\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\u7684\u5408\u6210\u88ab\u5f88\u5927\u7a0b\u5ea6\u88ab\u5ffd\u7565\u4e86(Scheme 1A)\u3002Kawabata\u8bfe\u9898\u7ec4[1]\u6210\u529f\u6784\u5efa\u4e86\u4e00\u7cfb\u5217\u5206\u5b50\u5185\u5177\u6709N-H-N\u6c22\u952e\u7684\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\uff0c\u4f46\u8be5\u7c7b\u5316\u5408\u7269\u5bf9\u5206\u5b50\u5185\u6c22\u952e\u7684\u957f\u5ea6\u6781\u5176\u654f\u611f\uff0c\u82e5\u53bb\u6389\u82b3\u57fa\u4e0a\u7684\u5438\u7535\u5b50\u57fa\uff0c\u76f8\u5e94\u5316\u5408\u7269\u7684\u7acb\u4f53\u5316\u5b66\u7a33\u5b9a\u6027\u5219\u4f1a\u8fc5\u901f\u964d\u4f4e(Scheme 1B)\u3002\u6700\u8fd1\uff0cClayden\u8bfe\u9898\u7ec4[2]\u6784\u5efa\u4e86\u5206\u5b50\u5185\u65e0\u6c22\u952e\u4f5c\u7528\u7684\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\uff0c\u4f46\u8fd9\u7c7b\u5316\u5408\u7269\u5728\u5ba4\u6e29\u6761\u4ef6\u4e0b\u90fd\u4f1a\u8fc5\u901f\u6d88\u65cb\u5316(Scheme 1B)\u3002\u4e3a\u4e86\u5f00\u53d1\u65b0\u7684\u6709\u6548\u5408\u6210\u7acb\u4f53\u5316\u5b66\u7a33\u5b9a\u7684\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\uff0c\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u5dde\u7acb\u5927\u5b66Gustafson\u8bfe\u9898\u7ec4\u9996\u6b21\u62a5\u9053\u4e86\u624b\u6027\u78f7\u9178\u50ac\u5316N-\u82b3\u57fa\u918c\u7c7b\u5316\u5408\u7269\u7684\u4e0d\u5bf9\u79f0\u5364\u5316\u53cd\u5e94\uff0c\u80fd\u4ee5\u826f\u597d\u81f3\u4f18\u79c0\u7684\u6536\u7387\u548c\u9009\u62e9\u6027\u5f97\u5230\u4e00\u7cfb\u5217\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u53d1\u73b0\u6784\u5efa\u7684\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u80fa\u7c7b\u5316\u5408\u7269\u5206\u5b50\u5185\u5b58\u5728N-H-O\u6c22\u952e,\u6240\u4ee5\u8be5\u7c7b\u5316\u5408\u7269\u80fd\u7a33\u5b9a\u5b58\u5728\u3002 \u201cCatalytic Atroposelective Synthesis of N\u2011Aryl Quinoid Compounds\u201d Vaidya, S. D.; Toenjes, S. T.; Yamamoto, N.; Maddox, S. M.; Gustafson, J. L.* J. Am. Chem. Soc. 2020, 142, 2198-2203. DOI: 10.1021\/jacs.9b12994 Scheme 1. \u7814\u7a76\u80cc\u666f \u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd Jeffrey L. 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