{"id":32938,"date":"2020-06-19T09:03:03","date_gmt":"2020-06-19T01:03:03","guid":{"rendered":"\/\/www.gsbet888.com\/?p=32938"},"modified":"2020-06-19T09:03:03","modified_gmt":"2020-06-19T01:03:03","slug":"%e5%bc%95%e5%8f%91%e5%85%a8%e7%90%83%e8%8d%af%e4%bc%81%e5%a4%a7%e5%9c%b0%e9%9c%87%e7%9a%84ndma%e5%88%b0%e5%ba%95%e6%98%af%e4%bb%80%e4%b9%88%e6%9d%a5%e5%a4%b4%ef%bc%9f","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemnews\/2020\/06\/%e5%bc%95%e5%8f%91%e5%85%a8%e7%90%83%e8%8d%af%e4%bc%81%e5%a4%a7%e5%9c%b0%e9%9c%87%e7%9a%84ndma%e5%88%b0%e5%ba%95%e6%98%af%e4%bb%80%e4%b9%88%e6%9d%a5%e5%a4%b4%ef%bc%9f.html","title":{"rendered":"\u5f15\u53d1\u5168\u7403\u836f\u4f01\u5927\u5730\u9707\u7684NDMA\u5230\u5e95\u662f\u4ec0\u4e48\u6765\u5934\uff1f"},"content":{"rendered":"<p>\u672c\u6587\u4f5c\u8005:\u7af9\u60a0<\/p>\n<blockquote><p>\u8bba\u6587\u90e8\u5206\u7f16\u8bd1\u81ea\uff1a<a href=\"https:\/\/cen.acs.org\/pharmaceuticals\/pharmaceutical-chemicals\/NDMA-contaminant-found-multiple-drugs\/98\/i15?from=singlemessage\">The presence of the potential carcinogen NDMA in common drugs has triggered waves of recalls. What are drugmakers doing to address the problem?<\/a><\/p>\n<p>C&amp;EN, 2020, 98 (15), pp 27\u201331April 20, 2020 \u4f5c\u8005\uff1aLeigh Krietsch Boerner<\/p><\/blockquote>\n<p>2019\u5e74\u7684\u4e00\u5929\uff0c\u5206\u6790\u5316\u5b66\u516c\u53f8Valisure\u7684\u5206\u5b50\u751f\u7269\u5b66\u5bb6\u517cCEO David Light\u9762\u5bf9\u7740\u8c31\u56fe\u4e0a\u8d28\u8377\u6bd4\u4e3a<em>m\/z<\/em>=74\u7684\u5cf0\u9677\u5165\u6c89\u601d\uff0c\u8fd9\u6b63\u662f<em>N<\/em>-\u4e8c\u7532\u57fa\u4e9a\u785d\u80fa<strong>NDMA<\/strong>\uff08<em>N<\/em>-nitrosodimethylamine\uff09\u7684\u5206\u5b50\u79bb\u5b50\u5cf0\u3002\u6b64\u65f6\uff0cDavid Light\u6b63\u5728\u5f00\u59cb\u6838\u67e5\u516c\u53f8\u6240\u6709\u6279\u6b21\u836f\u54c1\u4e2d\u7684\u81f4\u764c\u7269\uff0c\u79d1\u7814\u4eba\u5458\u7528\u6c14\u76f8\u8272\u8c31-\u8d28\u8c31\u53cd\u590d\u9a8c\u8bc1\u540e\u624d\u786e\u8ba4\u6b63\u662f<strong>NDMA<\/strong>\uff0c\u4e00\u79cd\u5e7f\u6cdb\u5173\u6ce8\u7684\u6f5c\u5728\u81f4\u764c\u7269\u8d28\uff0c\u53c8\u540d\u57fa\u56e0\u9057\u4f20\u6bd2\u6027\u7269\u8d28\u3002NDMA\uff0c\u5373N-\u4e8c\u7532\u57fa\u4e9a\u785d\u80fa\u5c5e\u4e8e\u4e9a\u785d\u80fa\u7c7bN-nitrosamine\uff0c\u5316\u5b66\u7ed3\u6784\u4e3aR<sub>2<\/sub>N\u2013N=O\uff0c\u4e3b\u8981\u662f\u7531\u8131\u8d28\u5b50\u7684\u80fa\u7ed3\u5408\u4e86\u4e00\u4e2a\u4e9a\u785d\u57fa\u5f62\u6210\uff0c\u901a\u5e38\u662f\u4ef2\u80fa\u6216\u53d4\u80fa\u548c\u4e9a\u785d\u57fa\u5316\u8bd5\u5242\u53cd\u5e94\u5f97\u5230\u3002<\/p>\n<h4><strong>\u8b66\u544a\uff01\u836f\u54c1\u4e2d\u542b\u6709<\/strong><strong><em>N<\/em><\/strong><strong>&#8211;<\/strong><strong>\u4e8c\u7532\u57fa\u4e9a\u785d\u80fa<\/strong><strong>NDMA<\/strong><\/h4>\n<p>Valisure\u7684\u53d1\u73b0\u5e76\u4e0d\u662f\u4e2a\u4f8b\uff0c\u5b9e\u9645\u4e0a\u5728\u8fc7\u53bb\u51e0\u5e74\uff0c\u65e0\u8bba\u662f\u72ec\u7acb\u5b9e\u9a8c\u5ba4\u3001\u836f\u4f01\u6216\u76d1\u7ba1\u90e8\u95e8\u5728\u591a\u79cd\u836f\u7269\u4e2d\u53d1\u73b0\u4e86<strong>NDMA<\/strong>\u30022018\u5e74\uff0c\u8bfa\u534e Novartis\u9996\u5148\u53d1\u73b0\u5176\u6297\u9ad8\u8840\u538b\u836f\u4e2d\u7684\u7f2c\u6c99\u5766\u539f\u6599\u836f\u4e2d\u542b\u6709<strong>NDMA<\/strong> \u3002\u6b64\u540e\uff0c\u81f3\u5c116\u79cd\u836f\u7269\u542b\u6709<strong>NDMA<\/strong>\u53ca\u5176\u7c7b\u4f3c\u7269\uff0c\u88ab\u6570\u4ee5\u767e\u4e07\u4eba\u670d\u7528\u3002\u56e0\u4e3aNDMA\u4e3a\u6f5c\u5728\u7684\u81f4\u764c\u7269\uff0c\u4e3a\u5b89\u5168\u8003\u8651\uff0c\u76d1\u7ba1\u7ed3\u6784\u8d23\u4ee4\u4ea7\u54c1\u53ec\u56de\u30022018\u5e747\u6708\u53ec\u56de\u7f2c\u6c99\u5766\uff0c10\u6708\u53ec\u56de\u5384\u8d1d\u6c99\u5766\uff0c11\u6708\u53ec\u56de\u6c2f\u6c99\u5766\uff0c\u540e\u4e24\u4e2a\u542b\u6709<em>N<\/em>-\u4e9a\u785d\u57fa\u4e8c\u4e59\u80faNDEA 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https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-1-300x86.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-1-680x195.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-1-768x220.jpg 768w\" sizes=\"(max-width: 727px) 100vw, 727px\" 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Medicines Agency (EMA)\u4e5f\u6709\u76f8\u540c\u7684\u7ed3\u8bba\u3002<\/p>\n<p>\u4f46\u5373\u4f7f\u5982\u6b64\uff0cFDA\u4ecd\u51b3\u5b9a\u53ec\u56de\u542b<strong>NDMA<\/strong>\u7684\u836f\u7269\uff0c\u4f46\u8fd9\u4e9b\u53ec\u56de\u5728\u533b\u751f\u548c\u60a3\u8005\u4e4b\u95f4\u5f15\u8d77\u4e86\u6050\u614c\u3002\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u540d\u5355\u4e2d\u5305\u62ec\u4e86\u91cd\u8981\u7684\u57fa\u7840\u836f\u7269\u3002\u5982\u6c99\u5766\u7c7b\u6297\u9ad8\u8840\u538b\u836f\u7269\u7684\u5384\u8d1d\u6c99\u5766irbesartan, \u7f2c\u6c99\u5766valsartan,\u6c2f\u6c99\u5766 losartan\u5217\u5165\u4e86WHO\u7684\u57fa\u672c\u836f\u7269\uff0c2017\u5e74\u5168\u7403\u7ea6\u6709\u4e00\u5343\u4e07\u4eba\u670d\u7528\u4e86\u6c2f\u6c99\u5766\uff0c\u4e8c\u767e\u591a\u4e07\u4eba\u670d\u7528\u5384\u8d1d\u6c99\u5766\uff0c\u8fd1\u4e24\u5343\u4e07\u4eba\u670d\u7528\u4e86\u7f2c\u6c99\u5766\u3002\u5982\u679c\u533b\u751f\u91cd\u65b0\u6362\u6cbb\u7597\u9ad8\u8840\u538b\u7684\u836f\u7269\uff0c\u610f\u5473\u7740\u66f4\u591a\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3001\u66f4\u591a\u7684\u76d1\u6d4b\uff0c\u66f4\u591a\u7684\u5b9e\u9a8c\u5ba4\u68c0\u6d4b\uff0c\u5360\u7528\u66f4\u591a\u533b\u7597\u8d44\u6e90\u3002<\/p>\n<h4><strong>\u836f\u54c1\u4e2d\u7684<\/strong><strong>NDMA<\/strong><strong>\u662f\u54ea\u6765\u7684\uff1f<\/strong><\/h4>\n<p>\u95ee\u9898\u662f\u836f\u54c1\u4e2d\u7684NDMA\u662f\u54ea\u6765\u7684\uff1f\u8fd9\u9700\u8981\u836f\u7269\u5316\u5b66\u548c\u5206\u6790\u5316\u5b66\u4e13\u5bb6\u7684\u5171\u540c\u52aa\u529b\u3002\u5bf9\u539f\u6599\u836f\u800c\u8a00\uff0c\u65e0\u5916\u4e4e\u836f\u7269\u5408\u6210\u4e2d\u7684\u526f\u53cd\u5e94\uff0c\u4e0d\u7a33\u5b9a\u836f\u7269\u7684\u964d\u89e3\uff0c\u56de\u6536\u6eb6\u5242\u4e2d\u5f15\u5165\uff0c\u770b\u8d77\u6765\u867d\u7136\u7b80\u5355\uff0c\u8fd9\u9700\u8981\u4e86\u89e3\u836f\u7269\u7ed3\u6784\u548c\u5408\u6210\u8def\u7ebf\uff0c\u836f\u54c1\u7684\u5305\u88c5\u548c\u8d2e\u85cf\u65b9\u5f0f\uff0c\u4f46\u6bcf\u79cd\u836f\u7269\u5404\u4e0d\u76f8\u540c\uff0c\u60f3\u5f7b\u5e95\u5f04\u6e05\u695a\u6bcf\u4e2a\u836f\u54c1\u4ecd\u662f\u975e\u5e38\u8270\u5de8\u7684\u4efb\u52a1\u3002\u5f62\u6210N-\u4e9a\u785d\u80fa\u9700\u8981\u4e9a\u785d\u57fa\u548c\u4e8c\u7532\u57fa\u80fa\u8fd9\u4e24\u90e8\u5206\u5316\u5b66\u7ed3\u6784\uff0c\u5e76\u4e14\u8ddd\u79bb\u8db3\u591f\u8fd1\u624d\u6709\u53ef\u80fd\u53d1\u751f\u3002\u95ee\u9898\u7684\u96be\u70b9\u662f\u4e0d\u80fd\u5217\u51fa\u6bcf\u4e2a\u836f\u7269\u6240\u6709\u7684\u5408\u6210\u8def\u7ebf\u6765\u5206\u6790\u3002<\/p>\n<p>\u5982\u963f\u65af\u5229\u5eb7AstraZeneca\u7684\u7f2c\u6c99\u5766\uff0c\u5206\u5b50\u7ed3\u6784\u4e2d\u65e2\u6ca1\u6709\u4e9a\u785d\u57fa\u4e5f\u6ca1\u6709\u80fa\uff0c\u95ee\u9898\u51fa\u5728\u5408\u6210\u8def\u7ebf\u4e0a\u3002\u8bfa\u534e\u6700\u521d\u7684\u5408\u6210\u5de5\u827a\u4e2d\uff0c\u7528\u4e09\u4e01\u57fa\u53e0\u6c2e\u5f62\u6210\u56db\u6c2e\u5511\uff0c\u4e8c\u7532\u82ef\u4e3a\u6eb6\u5242\uff0c\u5408\u6210\u8def\u7ebf\u89c1scheme 1\u3002\u4f46\u57282014\u5e74\uff0c\u6d59\u6c5f\u534e\u6d77\u836f\u4e1a\u6539\u8fdb\u4e86\u5408\u6210\u8def\u7ebf\uff0c\u4f7f\u7528\u53e0\u6c2e\u5316\u94a0\uff0c\u5e76\u5c06\u6eb6\u5242\u66ff\u6362\u4e3aDMF\uff0c\u6536\u7387\u66f4\u9ad8\uff0c\u4f46DMF\u5c06\u964d\u89e3\u751f\u6210\u4e8c\u7532\u80fa\uff0c\u5e76\u7528\u4e9a\u785d\u9178\u94a0\u6dec\u706d\u8fc7\u91cf\u7684\u53e0\u6c2e\u5316\u94a0\uff0c\u8fd9\u6837\u65e2\u6709\u4e8c\u7532\u80fa\u53c8\u6709\u4e9a\u785d\u57fa\uff0c\u987a\u7406\u6210\u7ae0\u4ece\u800c\u751f\u6210\u4e86<strong>NDMA<\/strong>\u3002<sup>[1]<\/sup>\u4ece\u6b64\uff0c\u534e\u6d77\u7f2c\u6c99\u5766\u4e8b\u4ef6\u63ed\u5f00\u4e86<strong>NDMA<\/strong>\u7bc7\u7ae0\u7684\u5e8f\u5e55\uff0c\u4e00\u4e2a\u53c8\u4e00\u4e2a\u91cd\u78c5\u836f\u7269\u66b4\u96f7\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32940 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-1.jpg\" alt=\"\" width=\"674\" height=\"585\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-1.jpg 1269w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-1-300x260.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-1-680x590.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-1-768x666.jpg 768w\" sizes=\"(max-width: 674px) 100vw, 674px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 1 \u8bfa\u534e\u7684\u7f2c\u6c99\u5766\u5408\u6210\u8def\u7ebf.<\/p>\n<p>Ranitidine\u96f7\u5c3c\u66ff\u4e01\u662f\u4e2a\u7ed3\u6784\u4e0d\u7a33\u5b9a\u7684\u836f\u7269\uff0c\u4f1a\u964d\u89e3\u4ea7\u751f<strong>NDMA<\/strong>\uff0c\u52a0\u70ed\u4f1a\u52a0\u901f\u964d\u89e3\uff0c\u5728\u8d2e\u85cf\u8fc7\u7a0b\u4e2d\u4f1a\u4ea7\u751f<strong>NDMA<\/strong>\u3002\u5b83\u7684\u4ea7\u751f\u673a\u7406\u6709\u5f88\u591a\u63a8\u6d4b\uff0c\u5982\u548c\u5e7f\u6cdb\u5b58\u5728\u7684\u6c2f\u80fa\u53cd\u5e94\uff0cScheme 2\u6240\u793a\u3002<sup>[2]<\/sup>\u5f53\u5b83\u91cd\u8fd4\u5e02\u573a\u65f6\uff0c\u9700\u8981\u63a7\u5236\u8fd0\u8f93\u53ca\u8d2e\u85cf\u6e29\u5ea6\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32941 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3.jpg\" alt=\"\" width=\"613\" height=\"747\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3.jpg 1535w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-246x300.jpg 246w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-680x829.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-768x936.jpg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-1260x1536.jpg 1260w\" sizes=\"(max-width: 613px) 100vw, 613px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 2. \u6c2f\u80fa\u548c\u96f7\u5c3c\u66ff\u4e01\u53cd\u5e94\u751f\u6210NDMA<\/p>\n<p>\u5e9f\u6c34\u4e5f\u53ef\u80fd\u4ea7\u751fNDMA\uff0c\u800c\u4e14\u5e9f\u6c34\u7684\u6210\u5206\u66f4\u590d\u6742\u3002\u5982\u901a\u8fc7\u4e8c\u7532\u57fa\u80bcUDMH\u6c27\u5316\u964d\u89e3\u4ea7\u751f<strong>NDMA<\/strong><strong>\uff0c<\/strong>\u5728\u7a7a\u6c14\u4e2d\u5c31\u53ef\u4ee5\u8fdb\u884c\u3002DMF\u964d\u89e3\u4e3a\u4e8c\u7532\u80fa\uff0c\u7136\u540e\u88ab\u6c22\u6c27\u5316\u94f5\u6216\u6b21\u6c2f\u9178\u94a0NaOCl\u6c28\u5316\uff0c\u518d\u548c\u5176\u5b83\u4eb2\u6838\u6027\u7684\u80fa\u5982NH<sub>2<\/sub>Cl\u53cd\u5e94\uff0c\u751f\u6210\u4e8c\u7532\u57fa\u80bc\uff0c\u518d\u88ab\u6c27\u5316\u4e3aNDMA\uff0c\u5982scheme 3\u6240\u793a\u3002<sup>[3]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32942 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4.jpg\" alt=\"\" width=\"610\" height=\"788\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4.jpg 875w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-232x300.jpg 232w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-680x878.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-768x992.jpg 768w\" sizes=\"(max-width: 610px) 100vw, 610px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 3. \u5e9f\u6c34\u4e2d\u4ea7\u751fNDMA.<\/p>\n<p>\u4e8c\u7532\u53cc\u80cd\u4ea7\u751f<strong>NDMA<\/strong>\u7684\u673a\u7406\u8fd8\u6ca1\u6709\u786e\u5b9a\uff0c\u5b83\u7684\u7ed3\u6784\u4e2d\u542b\u6709\u4e8c\u7532\u80fa\uff0c\u5e76\u4e14\u5408\u6210\u8def\u7ebf\u4ec5\u6709\u4e00\u90e8\u53cd\u5e94\uff0c\u5176\u4e2d\u8d77\u59cb\u7269\u6599\u4e4b\u4e00\u4e3a\u4e8c\u7532\u80fa\uff0c\u56e0\u6b64\u5982\u679c\u6709\u75d5\u91cf\u7684\u4e9a\u785d\u5316\u8bd5\u5242\u5f15\u5165\uff0c\u5c31\u53ef\u80fd\u4ea7\u751fNDMA\uff0c\u5e76\u4e14\u4e9a\u785d\u5316\u8bd5\u5242\u7684\u5f15\u5165\u9014\u5f84\u66f4\u591a\u3002\u4e8c\u7532\u53cc\u80cd\u6c27\u5316\u88c2\u89e3\u6db2\u4f1a\u4ea7\u751f<strong>NDMA<\/strong>\u3002<sup>[4]<\/sup><\/p>\n<h4><strong>Dead line<\/strong><strong>\u5df2\u5212\u597d\uff0c\u76d1\u7ba1\u673a\u6784\u5728\u884c\u52a8<\/strong><strong>!<\/strong><\/h4>\n<p>\u836f\u54c1\u76d1\u7ba1\u673a\u6784\u5df2\u7ecf\u610f\u8bc6\u5230\u95ee\u9898\u7684\u4e25\u91cd\u6027\uff0c\u56e0\u6b64\u8d23\u4efb\u836f\u4f01\u53ec\u56de\u4e0a\u5e02\u4ea7\u54c1\uff0c\u5e76\u5f7b\u67e5\u836f\u54c1\u7684NDMA\u542b\u91cf\u30022019\u5e749\u6708\uff0c\u6b27\u6d32\u836f\u76d1\u5c40\u7ed9\u51fa\u7684\u65f6\u95f4\u662f3\u5e74\u5185\u5b8c\u6210\u30022019\u5e7412\u6708\uff0c\u52a0\u62ff\u5927\u536b\u751f\u90e8\u8981\u6c422\u5e74\u5185\u6240\u6709\u4ea7\u54c1\u7684NDMA\u542b\u91cf\u5728\u5b89\u5168\u9650\u5ea6\u4ee5\u5185\u3002\u7f8e\u56fdFDA\u6b63\u5728\u89c4\u5212\u4e2d\u3002<\/p>\n<p>2020\u5e745\u67088\u65e5,\u6211\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u53d1\u5e03\u4e86\u300a\u5316\u5b66\u836f\u7269\u4e2d\u4e9a\u785d\u80fa\u7c7b\u6742\u8d28\u7814\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219 \uff08\u8bd5\u884c\uff09\u300b\uff0c\u8981\u6c42\u836f\u4f01\u5e94\u5145\u5206\u8bc4\u4f30\u836f\u54c1\u4e2d\u4e9a\u785d\u80fa\u7c7b\u6742\u8d28\u7684\u98ce\u9669 \uff0c \u5e76\u5c06\u4e9a\u785d\u80fa\u7c7b\u6742\u8d28\u6c34\u5e73\u63a7\u5236\u5728\u5b89\u5168\u9650\u5ea6\u4ee5\u4e0b\u3002<\/p>\n<h4>\u5176\u5b83\u53c2\u8003\u6587\u732e<\/h4>\n<ul>\n<li>[1] Maria Kristina Parra, Jan F. Josepha., NDMA impurity in valsartan and other pharmaceutical products:Analytical methods for the determination of N-nitrosamines. <em>Journal of Pharmaceutical and Biomedical Analysis<\/em> 164 (2019) 536\u2013549 DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.jpba.2018.11.010\">https:\/\/doi.org\/10.1016\/j.jpba.2018.11.010<\/a>.<\/li>\n<li>[2] Julien Le Roux, Herv\u00e9 Gallard, Jean-Philippe Crou\u00e9, S\u00e9bastien Papot, Marie Deborde.<\/li>\n<li>NDMA Formation by Chloramination of Ranitidine: Kinetics and Mechanism <em>Environ. Sci. Technol<\/em>. 2012, 46, 11095-11103 .DOI: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/es3023094\">10.1021\/es3023094<\/a>.<\/li>\n<li>[3] N-nitrosamines <em>Org. Process Res. Dev<\/em>\u00a0 DOI: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.oprd.9b00535\">10.1021\/acs.oprd.9b00535<\/a>.<\/li>\n<li>[4] Ismail Badran, Abdallah D. Manasrah, Nashaat N. Nassar., A combined experimental and density functional theory study of metformin oxy-cracking for pharmaceutical wastewater treatment. \u00a0<em>RSC Advances<\/em>. 2019, 9, 13403.DOI: <a href=\"https:\/\/doi.org\/10.1039\/C9RA01641D\">https:\/\/doi.org\/10.1039\/C9RA01641D<\/a><\/li>\n<\/ul>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<\/strong><a href=\"\/\/www.gsbet888.com\/\"><strong>Chem-Station\u5316\u5b66\u7a7a\u95f4<\/strong><\/a><strong>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005:\u7af9\u60a0 \u8bba\u6587\u90e8\u5206\u7f16\u8bd1\u81ea\uff1aThe presence of the potential carcinogen NDMA in common drugs has triggered waves of recalls. What are drugmakers doing to address the problem? C&amp;EN, 2020, 98 (15), pp 27\u201331April 20, 2020 \u4f5c\u8005\uff1aLeigh Krietsch Boerner 2019\u5e74\u7684\u4e00\u5929\uff0c\u5206\u6790\u5316\u5b66\u516c\u53f8Valisure\u7684\u5206\u5b50\u751f\u7269\u5b66\u5bb6\u517cCEO David Light\u9762\u5bf9\u7740\u8c31\u56fe\u4e0a\u8d28\u8377\u6bd4\u4e3am\/z=74\u7684\u5cf0\u9677\u5165\u6c89\u601d\uff0c\u8fd9\u6b63\u662fN-\u4e8c\u7532\u57fa\u4e9a\u785d\u80faNDMA\uff08N-nitrosodimethylamine\uff09\u7684\u5206\u5b50\u79bb\u5b50\u5cf0\u3002\u6b64\u65f6\uff0cDavid 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Ranitidine\u96f7\u5c3c\u66ff\u4e01\u662f\u4e2a\u7ed3\u6784\u4e0d\u7a33\u5b9a\u7684\u836f\u7269\uff0c\u4f1a\u964d\u89e3\u4ea7\u751fNDMA\uff0c\u52a0\u70ed\u4f1a\u52a0\u901f\u964d\u89e3\uff0c\u5728\u8d2e\u85cf\u8fc7\u7a0b\u4e2d\u4f1a\u4ea7\u751fNDMA\u3002\u5b83\u7684\u4ea7\u751f\u673a\u7406\u6709\u5f88\u591a\u63a8\u6d4b\uff0c\u5982\u548c\u5e7f\u6cdb\u5b58\u5728\u7684\u6c2f\u80fa\u53cd\u5e94\uff0cScheme 2\u6240\u793a\u3002[2]\u5f53\u5b83\u91cd\u8fd4\u5e02\u573a\u65f6\uff0c\u9700\u8981\u63a7\u5236\u8fd0\u8f93\u53ca\u8d2e\u85cf\u6e29\u5ea6\u3002 Scheme 2. \u6c2f\u80fa\u548c\u96f7\u5c3c\u66ff\u4e01\u53cd\u5e94\u751f\u6210NDMA \u5e9f\u6c34\u4e5f\u53ef\u80fd\u4ea7\u751fNDMA\uff0c\u800c\u4e14\u5e9f\u6c34\u7684\u6210\u5206\u66f4\u590d\u6742\u3002\u5982\u901a\u8fc7\u4e8c\u7532\u57fa\u80bcUDMH\u6c27\u5316\u964d\u89e3\u4ea7\u751fNDMA\uff0c\u5728\u7a7a\u6c14\u4e2d\u5c31\u53ef\u4ee5\u8fdb\u884c\u3002DMF\u964d\u89e3\u4e3a\u4e8c\u7532\u80fa\uff0c\u7136\u540e\u88ab\u6c22\u6c27\u5316\u94f5\u6216\u6b21\u6c2f\u9178\u94a0NaOCl\u6c28\u5316\uff0c\u518d\u548c\u5176\u5b83\u4eb2\u6838\u6027\u7684\u80fa\u5982NH2Cl\u53cd\u5e94\uff0c\u751f\u6210\u4e8c\u7532\u57fa\u80bc\uff0c\u518d\u88ab\u6c27\u5316\u4e3aNDMA\uff0c\u5982scheme 3\u6240\u793a\u3002[3] Scheme 3. \u5e9f\u6c34\u4e2d\u4ea7\u751fNDMA. \u4e8c\u7532\u53cc\u80cd\u4ea7\u751fNDMA\u7684\u673a\u7406\u8fd8\u6ca1\u6709\u786e\u5b9a\uff0c\u5b83\u7684\u7ed3\u6784\u4e2d\u542b\u6709\u4e8c\u7532\u80fa\uff0c\u5e76\u4e14\u5408\u6210\u8def\u7ebf\u4ec5\u6709\u4e00\u90e8\u53cd\u5e94\uff0c\u5176\u4e2d\u8d77\u59cb\u7269\u6599\u4e4b\u4e00\u4e3a\u4e8c\u7532\u80fa\uff0c\u56e0\u6b64\u5982\u679c\u6709\u75d5\u91cf\u7684\u4e9a\u785d\u5316\u8bd5\u5242\u5f15\u5165\uff0c\u5c31\u53ef\u80fd\u4ea7\u751fNDMA\uff0c\u5e76\u4e14\u4e9a\u785d\u5316\u8bd5\u5242\u7684\u5f15\u5165\u9014\u5f84\u66f4\u591a\u3002\u4e8c\u7532\u53cc\u80cd\u6c27\u5316\u88c2\u89e3\u6db2\u4f1a\u4ea7\u751fNDMA\u3002[4] Dead line\u5df2\u5212\u597d\uff0c\u76d1\u7ba1\u673a\u6784\u5728\u884c\u52a8! \u836f\u54c1\u76d1\u7ba1\u673a\u6784\u5df2\u7ecf\u610f\u8bc6\u5230\u95ee\u9898\u7684\u4e25\u91cd\u6027\uff0c\u56e0\u6b64\u8d23\u4efb\u836f\u4f01\u53ec\u56de\u4e0a\u5e02\u4ea7\u54c1\uff0c\u5e76\u5f7b\u67e5\u836f\u54c1\u7684NDMA\u542b\u91cf\u30022019\u5e749\u6708\uff0c\u6b27\u6d32\u836f\u76d1\u5c40\u7ed9\u51fa\u7684\u65f6\u95f4\u662f3\u5e74\u5185\u5b8c\u6210\u30022019\u5e7412\u6708\uff0c\u52a0\u62ff\u5927\u536b\u751f\u90e8\u8981\u6c422\u5e74\u5185\u6240\u6709\u4ea7\u54c1\u7684NDMA\u542b\u91cf\u5728\u5b89\u5168\u9650\u5ea6\u4ee5\u5185\u3002\u7f8e\u56fdFDA\u6b63\u5728\u89c4\u5212\u4e2d\u3002 2020\u5e745\u67088\u65e5,\u6211\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u53d1\u5e03\u4e86\u300a\u5316\u5b66\u836f\u7269\u4e2d\u4e9a\u785d\u80fa\u7c7b\u6742\u8d28\u7814\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219 \uff08\u8bd5\u884c\uff09\u300b\uff0c\u8981\u6c42\u836f\u4f01\u5e94\u5145\u5206\u8bc4\u4f30\u836f\u54c1\u4e2d\u4e9a\u785d\u80fa\u7c7b\u6742\u8d28\u7684\u98ce\u9669 \uff0c \u5e76\u5c06\u4e9a\u785d\u80fa\u7c7b\u6742\u8d28\u6c34\u5e73\u63a7\u5236\u5728\u5b89\u5168\u9650\u5ea6\u4ee5\u4e0b\u3002 \u5176\u5b83\u53c2\u8003\u6587\u732e [1] Maria Kristina Parra, Jan F. Josepha., NDMA impurity in valsartan and other pharmaceutical products:Analytical methods for the determination of N-nitrosamines. 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