{"id":32950,"date":"2020-06-18T08:00:52","date_gmt":"2020-06-18T00:00:52","guid":{"rendered":"\/\/www.gsbet888.com\/?p=32950"},"modified":"2020-06-18T16:33:28","modified_gmt":"2020-06-18T08:33:28","slug":"%e5%9c%a8%e7%bb%86%e8%83%9e%e4%b8%ad%e6%97%85%e8%a1%8c%e7%9a%84%e5%b0%8f%e5%88%86%e5%ad%90%ef%b8%b1%e7%ac%ac%e4%ba%8c%e7%af%87","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2020\/06\/%e5%9c%a8%e7%bb%86%e8%83%9e%e4%b8%ad%e6%97%85%e8%a1%8c%e7%9a%84%e5%b0%8f%e5%88%86%e5%ad%90%ef%b8%b1%e7%ac%ac%e4%ba%8c%e7%af%87.html","title":{"rendered":"\u5728\u7ec6\u80de\u4e2d\u65c5\u884c\u7684\u5c0f\u5206\u5b50\ufe31\u7b2c\u4e8c\u7bc7"},"content":{"rendered":"<p>\u672c\u6587\u6765\u81eaChem-Station\u65e5\u6587\u7248 <a href=\"https:\/\/www.chem-station.com\/blog\/2014\/11\/moleculettravelcell2.html\">\u7d30\u80de\u306e\u4e2d\u3092\u65c5\u3059\u308b\u5c0f\u5206\u5b50|\u7b2c\u4e8c\u56de<\/a> MasaN.<\/p>\n<p><strong>\u7ffb\u8bd1\u6295\u7a3f \u70b8\u9e21 \u6821\u5bf9 HaoHu<\/strong><\/p>\n<p>\u63a5\u7740<a href=\"\/\/www.gsbet888.com\/\u5316\u5b66\u6742\u8bb0\/2020\/06\/\u5728\u7ec6\u80de\u4e2d\u65c5\u884c\u7684\u5c0f\u5206\u5b50\ufe31\u7b2c\u4e00\u7bc7.html\">\u4e0a\u4e00\u7bc7<\/a>\u7684\u7ee7\u7eed\u8bb2\u3002\u4ece\u8fd9\u4e00\u7bc7\u8d77\u5c06\u4ece\u5927\u5c0f\u7684\u89c6\u89d2\u8ffd\u8e2a\u836f\u7269\u5206\u5b50\u5230\u8fbe\u9776\u7ec6\u80de\u5468\u56f4\u540e\uff0c\u662f\u5982\u4f55\u5230\u7ec6\u80de\u6838\u5185\u7684\u9776\u86cb\u767d\u8d28\u7684\u3002<\/p>\n<p>\u7b2c2\u56de\uff0c\u7ed9\u5927\u5bb6\u5e26\u6765\u7684\u662f\u836f\u7269\u5206\u5b50\u901a\u8fc7\u7ec6\u80de\u819c\u5230\u8fbe\u7ec6\u80de\u8d28\u4e16\u754c\u8fd9\u4e00\u6bb5\u7684\u65c5\u9014\u3002<\/p>\n<h4><strong>\u7a7f\u8d8a\u7ec6\u80de\u819c<\/strong><\/h4>\n<p>\u836f\u7269\u5c0f\u5206\u5b50\u4e00\u822c\u5728\u6c34\u4e2d\u7684\u957f\u5ea6\u4e3a<strong>10~30 \u00c5<\/strong><strong>\uff08<\/strong><strong>10<sup>-9<\/sup>\u00a0m<\/strong><strong>\uff09<\/strong>\u3002\u82ef\u73af\u957f\u5ea6\u7ea6\u4e3a4 \u00c5\uff0c\u8054\u82ef\uff08biphenyl\uff09\u4e0a\u5bf9\u4f4d\u7684\u78b3\u539f\u5b50\u4e4b\u95f4\u7684\u8ddd\u79bb\u670910 \u00c5\u3002\u4eba\u4f53\u7ec6\u80de\u7684\u76f4\u5f84\u901a\u5e38\u5728<strong>6~26 \u03bcm(10<\/strong><strong><sup>-5\u00a0<\/sup><\/strong><strong>m)<\/strong><strong>\u4e4b\u95f4<\/strong><strong>\u3002<\/strong><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32957 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-3.jpg\" alt=\"\" width=\"603\" height=\"406\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-3.jpg 1064w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-3-300x202.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-3-680x458.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-3-768x517.jpg 768w\" sizes=\"(max-width: 603px) 100vw, 603px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Fig.1 \u52a8\u7269\u7ec6\u80de\u7684\u76f4\u5f84\uff08Mol. Biol. Cell Fig.1-30 \uff09<\/p>\n<p>\u836f\u7269\u5206\u5b50\u5230\u8fbe\u9776\u7ec6\u80de\u5468\u56f4\u540e\u5c31\u8981\u8fdb\u5165\u7ec6\u80de\u4e86\u3002\u7ec6\u80de\u819c\u7684\u539a\u5ea6\u7ea6\u4e3a5nm\uff0c\u8ddf\u6574\u4e2a\u7ec6\u80de\u7684\u5927\u5c0f\u6bd4\u8d77\u6765\uff0c\u7ec6\u80de\u819c\u53ef\u4ee5\u8bf4\u662f\u76f8\u5f53\u8584\u7684\u4e00\u5c42\u4e86\uff08Fig.2\uff09\u3002\u867d\u7136\u7ec6\u80de\u819c\u975e\u5e38\u8584\uff0c<strong>\u4f46\u662f\u5b83\u5374\u662f\u5bf9\u7ec6\u80de\u751f\u547d\u6d3b\u52a8\u6700\u91cd\u8981\u7684\u4e00\u4e2a\u5668\u5b98<\/strong>\u3002\u5982\u679c\u6ca1\u6709\u7ec6\u80de\u819c\u7684\u8bdd\uff0c\u7ec6\u80de\u5185\u73af\u5883\u5c31\u4f1a\u548c\u7ec6\u80de\u5916\u73af\u5883\u76f4\u63a5\u63a5\u89e6\uff0c\u5916\u754c\u548c\u5185\u90e8\u7684\u7269\u8d28\u6d53\u5ea6\u5c31\u4e0d\u80fd\u8c03\u8282\uff0c\u7ec6\u80de\u5185\u5916\u7684\u7269\u8d28\u5c31\u4f1a\u76f8\u4e92\u6269\u6563\uff0c\u90a3\u4e48\u7ec6\u80de\u7684\u751f\u547d\u6d3b\u52a8\u4e5f\u5c31\u65e0\u6cd5\u8fdb\u884c\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32952 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-2.jpg\" alt=\"\" width=\"664\" height=\"251\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-2.jpg 1024w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-2-300x113.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-2-680x257.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-2-768x290.jpg 768w\" sizes=\"(max-width: 664px) 100vw, 664px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Fig.2 \u7ec6\u80de\u819c\uff08Mol.Biol.Cell Fig.10-1, Fig.10-5 \uff09\u5de6\u56fe\uff1a\u78f7\u8102\u53cc\u5206\u5b50\u5c42\u7ed3\u6784\u793a\u610f\u56fe \u9ec4\u8272\u5316\u5408\u7269\uff1a\u80c6\u56fa\u9187\uff09<\/p>\n<p>\u7ec6\u80de\u819c\u80fd\u5141\u8bb8\u901a\u8fc7\u50cf\u80c6\u56fa\u9187\u90a3\u6837\u5927\u5c0f\u7684\u5206\u5b50\uff081\u22123nm\uff09\u3002\u4e4b\u6240\u4ee5\u5f88\u591a\u836f\u7269\u5206\u5b50\u80fd\u901a\u8fc7\u7ec6\u80de\u819c\uff0c\u662f\u56e0\u4e3a\u7ec6\u80de\u819c\u662f\u8102\u6eb6\u6027\u7684\u518d\u52a0\u4e0a\u591a\u6570\u836f\u7269\u5206\u5b50\u4e5f\u90fd\u662f\u8102\u6eb6\u6027\u7684\uff0c\u6240\u4ee5\u836f\u7269\u5206\u5b50\u80fd\u5f88\u5bb9\u6613\u901a\u8fc7\u88ab\u52a8\u6269\u6563\u901a\u8fc7\u7ec6\u80de\u819c\u8fdb\u5165\u5230\u7ec6\u80de\u5185\u90e8\u3002\u4e00\u90e8\u5206\u836f\u7269\u5206\u5b50\u4f1a\u5229\u7528\u7ec6\u80de\u819c\u4e0a\u7684\u8f7d\u4f53\u901a\u8fc7\u4e3b\u52a8\u8fd0\u8f93\u8fdb\u5165\u7ec6\u80de\u5185\u3002\u4f46\u540c\u6837\u5730\uff0c\u5f88\u591a\u7ec6\u80de\u4e5f\u4f1a\u901a\u8fc7\u8f7d\u4f53\u6765\u5c06\u836f\u7269\u548c\u5f02\u7269\u6392\u51fa\u7ec6\u80de\u5916\uff0c\u6240\u4ee5\u5408\u6210\u5177\u6709\u826f\u597d\u7684\u819c\u901a\u900f\u6027\u7684\u65b0\u836f\u5206\u5b50\u662f\u5f00\u53d1\u65b0\u836f\u521d\u59cb\u9636\u6bb5\u91cd\u8981\u7684\u4e00\u6b65\u3002<\/p>\n<h4><strong>\u7ec6\u80de\u5185\u7684\u4e16\u754c<\/strong><strong>&#8211;<\/strong><strong>\u7ec6\u80de\u8d28<\/strong><\/h4>\n<p>\u7a7f\u8d8a\u7ec6\u80de\u819c\u5c31\u5230\u4e86\u7ec6\u80de\u5185\u90e8\u7684\u4e16\u754c\u4e86\u3002\u7ec6\u80de\u5185\u6709\u5404\u79cd\u5404\u6837\u7684\u7ec6\u80de\u5668\u88ab\u5404\u79cd\u7ec6\u80de\u5668\u819c\u5305\u88f9\u3002\u7ec6\u80de\u5668\u53ea\u5360\u7ec6\u80de\u8d28\u4f53\u79ef\u5f88\u5c0f\u7684\u4e00\u90e8\u5206\uff0c\u7ec6\u80de\u5668\u4ee5\u5916\u7684\u5927\u90e8\u5206\u90fd\u662f\u7ec6\u80de\u8d28\u3002\u8bf7\u5927\u5bb6\u628a\u76ee\u5149\u843d\u5728Fig.3\u4e0a\u3002\u56fe\u4e2d\u5e26\u989c\u8272\u7684\u7269\u8d28\u8868\u793a\u7684\u662fRNA\u548c\u86cb\u767d\u8d28\uff0c\u56fe\u4e2d\u7684\u5206\u5e03\u90fd\u662f\u57fa\u4e8eRNA\u548c\u86cb\u767d\u8d28\u5728\u7ec6\u80de\u4e2d\u7684\u5b9e\u9645\u6d53\u5ea6(1,2)\u3002\u5927\u5206\u5b50\u5728\u7ec6\u80de\u8d28\u4e2d\u7684\u6d53\u5ea6\u4e3a138mM\uff0c\u76f8\u6bd4\u4e8e\u5927\u5206\u5b50\u5728\u8840\u6db2\u4e2d\u7684\u6d53\u5ea6\u53ea\u67099 mM\uff0c\u5927\u5206\u5b50\u5728\u7ec6\u80de\u8d28\u4e2d\u7684\u6d53\u5ea6\u53ef\u4ee5\u7b97\u662f\u9ad8\u4e86\u3002\u53ef\u4ee5\u8fd9\u4e48\u8bf4\u5427\uff0c\u7ec6\u80de\u8d28\u5c31\u76f8\u5f53\u4e8e\u4e00\u7897\u6d53\u7a20\u7684\u201c\u5927\u5206\u5b50\u6c64\u201d\u3002\u6240\u4ee5\uff0c\u5c0f\u5206\u5b50\u8fdb\u5165\u7ec6\u80de\u540e\u7684\u6269\u6563\u901f\u5ea6\u53ea\u6709\u5927\u5206\u5b50\u76841\/4\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32953 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-1.jpg\" alt=\"\" width=\"708\" height=\"269\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-1.jpg 1208w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-1-300x114.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-1-680x258.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-1-768x291.jpg 768w\" sizes=\"(max-width: 708px) 100vw, 708px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Fig.3 Cytosol: protein soup\u3000\uff08Mol.Biol.Cell Fig.2-49 \uff09<\/p>\n<p>Fig.4\u5217\u4e3e\u4e86\u4e86\u4eba\u4f53\u4e2d\u7684\u4e00\u4e9b\u86cb\u767d\u8d28\uff08\u5305\u62ec\u4e86\u7ec6\u80de\u6838\u5185\u7684\u548cDNA\u7ed3\u5408\u7684\u86cb\u767d\u8d28\u4e0e\u7ec6\u80de\u5916\u7684\u6784\u9020\u86cb\u767d\u8d28\uff09\u3002<\/p>\n<p>\u9ec4\u8272\u7684\u21d4\u8868\u793a\uff15nm\u3002\u86cb\u767d\u8d28\u7684\u5e73\u5747\u6b8b\u57fa\u6570\u5927\u7ea6\u662f422\u3002\u8bb8\u591a\u836f\u7269\uff0c\u6bd4\u5982\u9176\u548c\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u6291\u5236\u5242\uff0c\u76ee\u6807\u86cb\u767d\u8d28\u662f\u5b58\u5728\u4e8ecytosol\u4e2d\u7684\u86cb\u767d\u8d28\u3002\u62ff\u6709\u6291\u5236\u4f5c\u7528\u7684\u9176\u6765\u8bf4\uff0c\u6709\u8f6c\u79fbATP\u4e0a\u7684\u78f7\u9178\u57fa\u56e2\u5230\u86cb\u767d\u8d28\u7684Tyr\u548cThr\u6b8b\u57fa\u4fa7\u94fe\u4e0a\u7684\u7f9f\u57fa\u7684\u78f7\u9178\u6fc0\u9176\uff0c\u548c\u4ee5\u751f\u7269\u4f53\u5185\u7684\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u4f5c\u4e3a\u53cd\u5e94\u57fa\u8d28\u7684\u9176\u4ee5\u53ca\u548c\u8f85\u9176\u53cd\u5e94\u7684\u9176\u3002\u4f46\u662f\u4e3a\u4ec0\u4e48\u9176\u86cb\u767d\u548c\u5c0f\u5206\u5b50\u7684\u5927\u5c0f\u4e0d\u540c\uff0c\u5374\u540c\u6837\u8d77\u5230\u6291\u5236\u7684\u4f5c\u7528\u5462\uff1f\u662f\u56e0\u4e3a\u9176\u53e3\u888b\u5f88\u5927\u5f88\u6df1\uff0c\u6240\u4ee5\u6291\u5236\u5242\u4f1a\u7ed3\u5408\u5728\u57fa\u8d28\u8bc6\u522b\u90e8\u4f4d\u5468\u56f4\uff0c\u4ece\u800c\u65e0\u6cd5\u4e0e\u751f\u7269\u4f53\u5185\u539f\u672c\u7684\u57fa\u8d28\u7ed3\u5408\uff08\u5373\u4f7f\u9176\u86cb\u767d\u548c\u5c0f\u5206\u5b50\u4e0d\u7ade\u4e89\u7ed3\u5408\u57fa\u8d28\u8bc6\u522b\u90e8\u4f4d\uff0c\u86cb\u767d\u8d28\u4e5f\u4f1a\u56e0\u4e3a\u4e0e\u5c0f\u5206\u5b50\u7684\u7ed3\u5408\u800c\u53d8\u6027\uff0c\u6240\u4ee5\u9176\u4e5f\u65e0\u6cd5\u548c\u751f\u7269\u4f53\u5185\u672c\u6765\u7684\u57fa\u8d28\u7ed3\u5408\uff09\u3002<\/p>\n<p>\u6291\u5236<strong>\u86cb\u767d<\/strong><strong>&#8211;<\/strong><strong>\u86cb\u767d\u76f8\u4e92\u4f5c\u7528<\/strong><strong>(Protein-Protein Interactions; PPI)<\/strong>\u7684\u6291\u5236\u5242\u9700\u8981\u6291\u5236\u86cb\u767d\u4e4b\u95f4\u7684\u5927\u9762\u79ef\u7684\u53cd\u5e94\uff0c\u6240\u4ee5\u4e00\u5ea6\u6709\u5f88\u957f\u4e00\u6bb5\u65f6\u95f4\uff0c\u4eba\u4eec\u8ba4\u4e3a\u53ea\u80fd\u4ece\u81ea\u7136\u4e2d\u83b7\u53d6FK506\u3001cyclosporin\uff0c<a href=\"http:\/\/www.chem-station.com\/molecule\/naturalmol\/2007\/09\/paclitaxeltaxol.html\">taxol<\/a>,\u00a0vincristine\u7b49\u6291\u5236\u5242\uff0c\u800c\u4e0d\u80fd\u4eba\u5de5\u5408\u6210\u3002\u4f46\u662f\u73b0\u5728\u5f88\u591a\u7528<a href=\"http:\/\/www.chem-station.com\/chemglossary\/2012\/05\/quorum_sensing.html\">FBDD<\/a>\uff08Fragment based drug design\uff09\u7684\u65b9\u6cd5\u518d\u57fa\u4e8e\u836f\u7269\u6784\u6548\u5173\u7cfb\u5408\u6210\u7684\u836f\u7269\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u4e86\u3002<strong>\u73b0\u5982\u4eca\u5f88\u591a\u533b\u836f\u5de5\u4f5c\u8005\u90fd\u80fd\u5b9e\u9645\u611f\u53d7\u5230\u5408\u6210\u7279\u5f02\u6027\u963b\u788d<\/strong><strong>PPI<\/strong><strong>\u7684\u836f\u7269\u5df2\u7ecf\u6210\u4e3a\u4e86\u73b0\u5b9e<\/strong>\u3002\u5173\u4e8ePPI\u7684\u4ecb\u7ecd\u9700\u8981\u5927\u7bc7\u5e45\uff0c\u6240\u4ee5\u8fd9\u91cc\u4e0d\u505a\u8fc7\u591a\u8d58\u8ff0\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32954 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-1.jpg\" alt=\"\" width=\"650\" height=\"815\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-1.jpg 783w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-1-239x300.jpg 239w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-1-680x852.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-1-768x962.jpg 768w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Fig.4 \u86cb\u767d\u8d28<\/p>\n<p>\u8ba9\u6211\u4eec\u8fd1\u8ddd\u79bb\u770b\u770b\u86cb\u767d\u8d28\u5427\u3002<\/p>\n<p>\u76f8\u4fe1\u5927\u5bb6\u90fd\u77e5\u9053\uff0c\u86cb\u767d\u8d28\u67092\u7ea7\u7ed3\u6784\u548c3\u7ea7\u7ed3\u6784\uff0c\u4e4b\u4e0a\u8fd8\u67094\u7ea7\u7ed3\u6784\uff08\u591a\u80bd\u94fe\u5305\u62ec\u975e\u5171\u4ef7\u952e\u805a\u5408\u7684\u590d\u5408\u4f53\u3001\u591a\u86cb\u767d\u590d\u5408\u4f53\uff1b\u8840\u7ea2\u86cb\u767d\uff0cDNA\u805a\u5408\u9176\uff0c\u6838\u82f7\u9178\uff0c\u5fae\u7ba1\uff09\u3002\u5982\u679c\u6211\u4eec\u964d\u7ef4\u5230\u5b83\u7684\u4e8c\u7ea7\u7ed3\u6784\u6765\u770b\uff0c\u6211\u4eec\u5c31\u80fd\u4ece\u5206\u6790\u5c0f\u5206\u5b50\u7684\u89d2\u5ea6\u6765\u89c2\u5bdf\u5b83\u3002\u5177\u6709\u4ee3\u8868\u6027\u7684\u03b1-Helix\u548c\u03b2-sheet\u7684\u6784\u9020\u5df2\u7ecf\u5728\u56fe\u4e2d\u5c55\u793a\u4e86\uff08Fig.5\uff09\u3002\u4ed4\u7ec6\u89c2\u5bdf\u5316\u5408\u7269\u7684\u7ed3\u6784\uff0c\u4f60\u5c31\u4f1a\u53d1\u73b0\u5b83\u4eec\u4e4b\u95f4\u5b58\u5728\u7684\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/5-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-32955 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/5-1.jpg\" alt=\"\" width=\"628\" height=\"433\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/5-1.jpg 1231w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/5-1-300x207.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/5-1-680x468.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/5-1-768x529.jpg 768w\" sizes=\"(max-width: 628px) 100vw, 628px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Fig.5 secondary structure (Mol. Biol. Cell Fig.3-1, 3-7 )<\/p>\n<p>\u4eca\u5929\u7684\u5185\u5bb9\u5230\u8fd9\u91cc\u5c31\u7ed3\u675f\u4e86\u3002<\/p>\n<p>\u4e0b\u4e00\u7bc7\u5c31\u662f\u6700\u7ec8\u7bc7\u4e86\u3002\uff08\u4e0b\u7bc7\u7bc7\u5e45\u4f1a\u6bd4\u8f83\u957f\uff09\u4e0b\u7bc7\u91cc\u6211\u4eec\u5c06\u4fb5\u5165\u7ec6\u80de\u6838\u5185\u7684\u4e16\u754c\uff0c\u5728\u4e0b\u4e00\u7bc7\u91cc\u4f1a\u505a\u4e2a\u603b\u7ed3\u3002<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] Molecular biology of the Cell (5<sup>th<\/sup>edition, Garland Science)<\/li>\n<li>[2] D.S.Goodsell, <em>Trends in Biochem. Sci<\/em>.\u00a0<strong>1991<\/strong>,\u00a0<em>16<\/em>, 203-206.<\/li>\n<\/ul>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<\/strong><a href=\"\/\/www.gsbet888.com\/\"><strong>Chem-Station\u5316\u5b66\u7a7a\u95f4<\/strong><\/a><strong>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u6765\u81eaChem-Station\u65e5\u6587\u7248 \u7d30\u80de\u306e\u4e2d\u3092\u65c5\u3059\u308b\u5c0f\u5206\u5b50|\u7b2c\u4e8c\u56de MasaN. \u7ffb\u8bd1\u6295\u7a3f \u70b8\u9e21 \u6821\u5bf9 HaoHu \u63a5\u7740\u4e0a\u4e00\u7bc7\u7684\u7ee7\u7eed\u8bb2\u3002\u4ece\u8fd9\u4e00\u7bc7\u8d77\u5c06\u4ece\u5927\u5c0f\u7684\u89c6\u89d2\u8ffd\u8e2a\u836f\u7269\u5206\u5b50\u5230\u8fbe\u9776\u7ec6\u80de\u5468\u56f4\u540e\uff0c\u662f\u5982\u4f55\u5230\u7ec6\u80de\u6838\u5185\u7684\u9776\u86cb\u767d\u8d28\u7684\u3002 \u7b2c2\u56de\uff0c\u7ed9\u5927\u5bb6\u5e26\u6765\u7684\u662f\u836f\u7269\u5206\u5b50\u901a\u8fc7\u7ec6\u80de\u819c\u5230\u8fbe\u7ec6\u80de\u8d28\u4e16\u754c\u8fd9\u4e00\u6bb5\u7684\u65c5\u9014\u3002 \u7a7f\u8d8a\u7ec6\u80de\u819c \u836f\u7269\u5c0f\u5206\u5b50\u4e00\u822c\u5728\u6c34\u4e2d\u7684\u957f\u5ea6\u4e3a10~30 \u00c5\uff0810-9\u00a0m\uff09\u3002\u82ef\u73af\u957f\u5ea6\u7ea6\u4e3a4 \u00c5\uff0c\u8054\u82ef\uff08biphenyl\uff09\u4e0a\u5bf9\u4f4d\u7684\u78b3\u539f\u5b50\u4e4b\u95f4\u7684\u8ddd\u79bb\u670910 \u00c5\u3002\u4eba\u4f53\u7ec6\u80de\u7684\u76f4\u5f84\u901a\u5e38\u57286~26 \u03bcm(10-5\u00a0m)\u4e4b\u95f4\u3002 Fig.1 \u52a8\u7269\u7ec6\u80de\u7684\u76f4\u5f84\uff08Mol. Biol. Cell Fig.1-30 \uff09 \u836f\u7269\u5206\u5b50\u5230\u8fbe\u9776\u7ec6\u80de\u5468\u56f4\u540e\u5c31\u8981\u8fdb\u5165\u7ec6\u80de\u4e86\u3002\u7ec6\u80de\u819c\u7684\u539a\u5ea6\u7ea6\u4e3a5nm\uff0c\u8ddf\u6574\u4e2a\u7ec6\u80de\u7684\u5927\u5c0f\u6bd4\u8d77\u6765\uff0c\u7ec6\u80de\u819c\u53ef\u4ee5\u8bf4\u662f\u76f8\u5f53\u8584\u7684\u4e00\u5c42\u4e86\uff08Fig.2\uff09\u3002\u867d\u7136\u7ec6\u80de\u819c\u975e\u5e38\u8584\uff0c\u4f46\u662f\u5b83\u5374\u662f\u5bf9\u7ec6\u80de\u751f\u547d\u6d3b\u52a8\u6700\u91cd\u8981\u7684\u4e00\u4e2a\u5668\u5b98\u3002\u5982\u679c\u6ca1\u6709\u7ec6\u80de\u819c\u7684\u8bdd\uff0c\u7ec6\u80de\u5185\u73af\u5883\u5c31\u4f1a\u548c\u7ec6\u80de\u5916\u73af\u5883\u76f4\u63a5\u63a5\u89e6\uff0c\u5916\u754c\u548c\u5185\u90e8\u7684\u7269\u8d28\u6d53\u5ea6\u5c31\u4e0d\u80fd\u8c03\u8282\uff0c\u7ec6\u80de\u5185\u5916\u7684\u7269\u8d28\u5c31\u4f1a\u76f8\u4e92\u6269\u6563\uff0c\u90a3\u4e48\u7ec6\u80de\u7684\u751f\u547d\u6d3b\u52a8\u4e5f\u5c31\u65e0\u6cd5\u8fdb\u884c\u3002 Fig.2 \u7ec6\u80de\u819c\uff08Mol.Biol.Cell Fig.10-1, Fig.10-5 \uff09\u5de6\u56fe\uff1a\u78f7\u8102\u53cc\u5206\u5b50\u5c42\u7ed3\u6784\u793a\u610f\u56fe \u9ec4\u8272\u5316\u5408\u7269\uff1a\u80c6\u56fa\u9187\uff09 \u7ec6\u80de\u819c\u80fd\u5141\u8bb8\u901a\u8fc7\u50cf\u80c6\u56fa\u9187\u90a3\u6837\u5927\u5c0f\u7684\u5206\u5b50\uff081\u22123nm\uff09\u3002\u4e4b\u6240\u4ee5\u5f88\u591a\u836f\u7269\u5206\u5b50\u80fd\u901a\u8fc7\u7ec6\u80de\u819c\uff0c\u662f\u56e0\u4e3a\u7ec6\u80de\u819c\u662f\u8102\u6eb6\u6027\u7684\u518d\u52a0\u4e0a\u591a\u6570\u836f\u7269\u5206\u5b50\u4e5f\u90fd\u662f\u8102\u6eb6\u6027\u7684\uff0c\u6240\u4ee5\u836f\u7269\u5206\u5b50\u80fd\u5f88\u5bb9\u6613\u901a\u8fc7\u88ab\u52a8\u6269\u6563\u901a\u8fc7\u7ec6\u80de\u819c\u8fdb\u5165\u5230\u7ec6\u80de\u5185\u90e8\u3002\u4e00\u90e8\u5206\u836f\u7269\u5206\u5b50\u4f1a\u5229\u7528\u7ec6\u80de\u819c\u4e0a\u7684\u8f7d\u4f53\u901a\u8fc7\u4e3b\u52a8\u8fd0\u8f93\u8fdb\u5165\u7ec6\u80de\u5185\u3002\u4f46\u540c\u6837\u5730\uff0c\u5f88\u591a\u7ec6\u80de\u4e5f\u4f1a\u901a\u8fc7\u8f7d\u4f53\u6765\u5c06\u836f\u7269\u548c\u5f02\u7269\u6392\u51fa\u7ec6\u80de\u5916\uff0c\u6240\u4ee5\u5408\u6210\u5177\u6709\u826f\u597d\u7684\u819c\u901a\u900f\u6027\u7684\u65b0\u836f\u5206\u5b50\u662f\u5f00\u53d1\u65b0\u836f\u521d\u59cb\u9636\u6bb5\u91cd\u8981\u7684\u4e00\u6b65\u3002 \u7ec6\u80de\u5185\u7684\u4e16\u754c&#8211;\u7ec6\u80de\u8d28 \u7a7f\u8d8a\u7ec6\u80de\u819c\u5c31\u5230\u4e86\u7ec6\u80de\u5185\u90e8\u7684\u4e16\u754c\u4e86\u3002\u7ec6\u80de\u5185\u6709\u5404\u79cd\u5404\u6837\u7684\u7ec6\u80de\u5668\u88ab\u5404\u79cd\u7ec6\u80de\u5668\u819c\u5305\u88f9\u3002\u7ec6\u80de\u5668\u53ea\u5360\u7ec6\u80de\u8d28\u4f53\u79ef\u5f88\u5c0f\u7684\u4e00\u90e8\u5206\uff0c\u7ec6\u80de\u5668\u4ee5\u5916\u7684\u5927\u90e8\u5206\u90fd\u662f\u7ec6\u80de\u8d28\u3002\u8bf7\u5927\u5bb6\u628a\u76ee\u5149\u843d\u5728Fig.3\u4e0a\u3002\u56fe\u4e2d\u5e26\u989c\u8272\u7684\u7269\u8d28\u8868\u793a\u7684\u662fRNA\u548c\u86cb\u767d\u8d28\uff0c\u56fe\u4e2d\u7684\u5206\u5e03\u90fd\u662f\u57fa\u4e8eRNA\u548c\u86cb\u767d\u8d28\u5728\u7ec6\u80de\u4e2d\u7684\u5b9e\u9645\u6d53\u5ea6(1,2)\u3002\u5927\u5206\u5b50\u5728\u7ec6\u80de\u8d28\u4e2d\u7684\u6d53\u5ea6\u4e3a138mM\uff0c\u76f8\u6bd4\u4e8e\u5927\u5206\u5b50\u5728\u8840\u6db2\u4e2d\u7684\u6d53\u5ea6\u53ea\u67099 mM\uff0c\u5927\u5206\u5b50\u5728\u7ec6\u80de\u8d28\u4e2d\u7684\u6d53\u5ea6\u53ef\u4ee5\u7b97\u662f\u9ad8\u4e86\u3002\u53ef\u4ee5\u8fd9\u4e48\u8bf4\u5427\uff0c\u7ec6\u80de\u8d28\u5c31\u76f8\u5f53\u4e8e\u4e00\u7897\u6d53\u7a20\u7684\u201c\u5927\u5206\u5b50\u6c64\u201d\u3002\u6240\u4ee5\uff0c\u5c0f\u5206\u5b50\u8fdb\u5165\u7ec6\u80de\u540e\u7684\u6269\u6563\u901f\u5ea6\u53ea\u6709\u5927\u5206\u5b50\u76841\/4\u3002 Fig.3 Cytosol: protein soup\u3000\uff08Mol.Biol.Cell Fig.2-49 \uff09 Fig.4\u5217\u4e3e\u4e86\u4e86\u4eba\u4f53\u4e2d\u7684\u4e00\u4e9b\u86cb\u767d\u8d28\uff08\u5305\u62ec\u4e86\u7ec6\u80de\u6838\u5185\u7684\u548cDNA\u7ed3\u5408\u7684\u86cb\u767d\u8d28\u4e0e\u7ec6\u80de\u5916\u7684\u6784\u9020\u86cb\u767d\u8d28\uff09\u3002 \u9ec4\u8272\u7684\u21d4\u8868\u793a\uff15nm\u3002\u86cb\u767d\u8d28\u7684\u5e73\u5747\u6b8b\u57fa\u6570\u5927\u7ea6\u662f422\u3002\u8bb8\u591a\u836f\u7269\uff0c\u6bd4\u5982\u9176\u548c\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u6291\u5236\u5242\uff0c\u76ee\u6807\u86cb\u767d\u8d28\u662f\u5b58\u5728\u4e8ecytosol\u4e2d\u7684\u86cb\u767d\u8d28\u3002\u62ff\u6709\u6291\u5236\u4f5c\u7528\u7684\u9176\u6765\u8bf4\uff0c\u6709\u8f6c\u79fbATP\u4e0a\u7684\u78f7\u9178\u57fa\u56e2\u5230\u86cb\u767d\u8d28\u7684Tyr\u548cThr\u6b8b\u57fa\u4fa7\u94fe\u4e0a\u7684\u7f9f\u57fa\u7684\u78f7\u9178\u6fc0\u9176\uff0c\u548c\u4ee5\u751f\u7269\u4f53\u5185\u7684\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u4f5c\u4e3a\u53cd\u5e94\u57fa\u8d28\u7684\u9176\u4ee5\u53ca\u548c\u8f85\u9176\u53cd\u5e94\u7684\u9176\u3002\u4f46\u662f\u4e3a\u4ec0\u4e48\u9176\u86cb\u767d\u548c\u5c0f\u5206\u5b50\u7684\u5927\u5c0f\u4e0d\u540c\uff0c\u5374\u540c\u6837\u8d77\u5230\u6291\u5236\u7684\u4f5c\u7528\u5462\uff1f\u662f\u56e0\u4e3a\u9176\u53e3\u888b\u5f88\u5927\u5f88\u6df1\uff0c\u6240\u4ee5\u6291\u5236\u5242\u4f1a\u7ed3\u5408\u5728\u57fa\u8d28\u8bc6\u522b\u90e8\u4f4d\u5468\u56f4\uff0c\u4ece\u800c\u65e0\u6cd5\u4e0e\u751f\u7269\u4f53\u5185\u539f\u672c\u7684\u57fa\u8d28\u7ed3\u5408\uff08\u5373\u4f7f\u9176\u86cb\u767d\u548c\u5c0f\u5206\u5b50\u4e0d\u7ade\u4e89\u7ed3\u5408\u57fa\u8d28\u8bc6\u522b\u90e8\u4f4d\uff0c\u86cb\u767d\u8d28\u4e5f\u4f1a\u56e0\u4e3a\u4e0e\u5c0f\u5206\u5b50\u7684\u7ed3\u5408\u800c\u53d8\u6027\uff0c\u6240\u4ee5\u9176\u4e5f\u65e0\u6cd5\u548c\u751f\u7269\u4f53\u5185\u672c\u6765\u7684\u57fa\u8d28\u7ed3\u5408\uff09\u3002 \u6291\u5236\u86cb\u767d&#8211;\u86cb\u767d\u76f8\u4e92\u4f5c\u7528(Protein-Protein Interactions; PPI)\u7684\u6291\u5236\u5242\u9700\u8981\u6291\u5236\u86cb\u767d\u4e4b\u95f4\u7684\u5927\u9762\u79ef\u7684\u53cd\u5e94\uff0c\u6240\u4ee5\u4e00\u5ea6\u6709\u5f88\u957f\u4e00\u6bb5\u65f6\u95f4\uff0c\u4eba\u4eec\u8ba4\u4e3a\u53ea\u80fd\u4ece\u81ea\u7136\u4e2d\u83b7\u53d6FK506\u3001cyclosporin\uff0ctaxol,\u00a0vincristine\u7b49\u6291\u5236\u5242\uff0c\u800c\u4e0d\u80fd\u4eba\u5de5\u5408\u6210\u3002\u4f46\u662f\u73b0\u5728\u5f88\u591a\u7528FBDD\uff08Fragment based drug design\uff09\u7684\u65b9\u6cd5\u518d\u57fa\u4e8e\u836f\u7269\u6784\u6548\u5173\u7cfb\u5408\u6210\u7684\u836f\u7269\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u4e86\u3002\u73b0\u5982\u4eca\u5f88\u591a\u533b\u836f\u5de5\u4f5c\u8005\u90fd\u80fd\u5b9e\u9645\u611f\u53d7\u5230\u5408\u6210\u7279\u5f02\u6027\u963b\u788dPPI\u7684\u836f\u7269\u5df2\u7ecf\u6210\u4e3a\u4e86\u73b0\u5b9e\u3002\u5173\u4e8ePPI\u7684\u4ecb\u7ecd\u9700\u8981\u5927\u7bc7\u5e45\uff0c\u6240\u4ee5\u8fd9\u91cc\u4e0d\u505a\u8fc7\u591a\u8d58\u8ff0\u3002 Fig.4 \u86cb\u767d\u8d28 \u8ba9\u6211\u4eec\u8fd1\u8ddd\u79bb\u770b\u770b\u86cb\u767d\u8d28\u5427\u3002 \u76f8\u4fe1\u5927\u5bb6\u90fd\u77e5\u9053\uff0c\u86cb\u767d\u8d28\u67092\u7ea7\u7ed3\u6784\u548c3\u7ea7\u7ed3\u6784\uff0c\u4e4b\u4e0a\u8fd8\u67094\u7ea7\u7ed3\u6784\uff08\u591a\u80bd\u94fe\u5305\u62ec\u975e\u5171\u4ef7\u952e\u805a\u5408\u7684\u590d\u5408\u4f53\u3001\u591a\u86cb\u767d\u590d\u5408\u4f53\uff1b\u8840\u7ea2\u86cb\u767d\uff0cDNA\u805a\u5408\u9176\uff0c\u6838\u82f7\u9178\uff0c\u5fae\u7ba1\uff09\u3002\u5982\u679c\u6211\u4eec\u964d\u7ef4\u5230\u5b83\u7684\u4e8c\u7ea7\u7ed3\u6784\u6765\u770b\uff0c\u6211\u4eec\u5c31\u80fd\u4ece\u5206\u6790\u5c0f\u5206\u5b50\u7684\u89d2\u5ea6\u6765\u89c2\u5bdf\u5b83\u3002\u5177\u6709\u4ee3\u8868\u6027\u7684\u03b1-Helix\u548c\u03b2-sheet\u7684\u6784\u9020\u5df2\u7ecf\u5728\u56fe\u4e2d\u5c55\u793a\u4e86\uff08Fig.5\uff09\u3002\u4ed4\u7ec6\u89c2\u5bdf\u5316\u5408\u7269\u7684\u7ed3\u6784\uff0c\u4f60\u5c31\u4f1a\u53d1\u73b0\u5b83\u4eec\u4e4b\u95f4\u5b58\u5728\u7684\u7684\u76f8\u4e92\u4f5c\u7528\u3002 Fig.5 secondary structure (Mol. Biol. Cell Fig.3-1, 3-7 ) \u4eca\u5929\u7684\u5185\u5bb9\u5230\u8fd9\u91cc\u5c31\u7ed3\u675f\u4e86\u3002 \u4e0b\u4e00\u7bc7\u5c31\u662f\u6700\u7ec8\u7bc7\u4e86\u3002\uff08\u4e0b\u7bc7\u7bc7\u5e45\u4f1a\u6bd4\u8f83\u957f\uff09\u4e0b\u7bc7\u91cc\u6211\u4eec\u5c06\u4fb5\u5165\u7ec6\u80de\u6838\u5185\u7684\u4e16\u754c\uff0c\u5728\u4e0b\u4e00\u7bc7\u91cc\u4f1a\u505a\u4e2a\u603b\u7ed3\u3002 \u53c2\u8003\u6587\u732e [1] Molecular biology of the Cell (5thedition, Garland Science) [2] D.S.Goodsell, Trends in Biochem. 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