{"id":33218,"date":"2020-07-05T08:20:34","date_gmt":"2020-07-05T00:20:34","guid":{"rendered":"\/\/www.gsbet888.com\/?p=33218"},"modified":"2020-06-29T22:55:21","modified_gmt":"2020-06-29T14:55:21","slug":"bc6f53%e5%82%ac%e5%8c%96%e5%90%b2%e5%93%9a%e4%b8%8e%e6%b0%a7%e5%8c%96%e5%90%b2%e5%93%9a%e7%9a%84%e7%9b%b4%e6%8e%a5c3%e7%83%b7%e5%9f%ba%e5%8c%96%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2020\/07\/bc6f53%e5%82%ac%e5%8c%96%e5%90%b2%e5%93%9a%e4%b8%8e%e6%b0%a7%e5%8c%96%e5%90%b2%e5%93%9a%e7%9a%84%e7%9b%b4%e6%8e%a5c3%e7%83%b7%e5%9f%ba%e5%8c%96%e5%8f%8d%e5%ba%94.html","title":{"rendered":"B(C6F5)3\u50ac\u5316\u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u7684\u76f4\u63a5C3\u70f7\u57fa\u5316\u53cd\u5e94"},"content":{"rendered":"

\u672c\u6587\u4f5c\u8005\uff1a\u6709\u673a\u5c0f\u767d<\/p>\n

\u5bfc\u8bfb<\/h4>\n

\u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u7684\u76f4\u63a5C3\u70f7\u57fa\u5316\u662f\u4e00\u4e2a\u975e\u5e38\u5177\u6709\u6311\u6218\u6027\u7684\u53cd\u5e94\uff0c\u8fc4\u4eca\u7684\u76f8\u5173\u62a5\u9053\u4e5f\u975e\u5e38\u5c11\u3002\u6700\u8fd1\uff0c\u82f1\u56fd\u83b1\u65af\u7279\u5927\u5b66Alexander P. Pulis\u4e0e\u82f1\u56fd\u5361\u8fea\u592b\u5927\u5b66Louis C. Morrill\u548cRebecca L. Melen\u8bfe\u9898\u7ec4\u5229\u7528\u4e09\u82b3\u57fa\u787c\u70f7\u80fd\u591f\u4fc3\u8fdb\u80fa\u4e2d\u03b1<\/em>-N C-H\u952e\u5f02\u88c2\u7684\u7279\u6027\uff0c\u5e76\u4f7f\u7528\u4e00\u79cd\u80fa\u884d\u751f\u7684\u70f7\u57fa\u5316\u8bd5\u5242\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u4e00\u7cfb\u5217\u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u7684\u76f4\u63a5C3\u70f7\u57fa\u5316\u53cd\u5e94\u3002\u53e6\u5916\uff0c\u4ed6\u4eec\u8fd8\u5c06\u8fd9\u79cd\u787c\u70f7\u50ac\u5316\u7684\u7b56\u7565\u5e94\u7528\u5230\u4e86\u70f7\u57fa\u5316\/\u5f00\u73af\u4e32\u8054\u53cd\u5e94\u4e4b\u4e2d\u3002<\/p>\n

B(C6<\/sub>F5<\/sub>)3<\/sub>-Catalyzed Direct C3 Alkylation of Indoles and Oxindoles<\/p>\n

Shyam Basak, Ana Alvarez-Montoya, Laura Winfrey, Rebecca L. Melen,* Louis C. Morrill,* and Alexander P. Pulis*<\/p>\n

ACS Catal.<\/em> 2020<\/strong>, 10<\/em>, 4835-4840\u00a0 DOI: 10.1021\/acscatal.0c01141<\/a><\/p><\/blockquote>\n

\"\"<\/a><\/p>\n

\uff08\u56fe\u7247\u6765\u6e90\uff1aACS Catalysis<\/em>\uff09<\/p>\n

\u6b63\u6587<\/h4>\n

\u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u662f\u751f\u7269\u6d3b\u6027\u5206\u5b50\u4e2d\u7684\u91cd\u8981\u7ed3\u6784\u3002\u7ecf\u5178\u7684\u5432\u54da\u5408\u6210\u65b9\u6cd5\u6d89\u53ca\u73af\u7684\u6784\u5efa\uff0c\u5176\u5b83\u4e00\u4e9b\u65b9\u6cd5\u4e5f\u53ea\u662f\u6d89\u53ca\u8fd9\u4e9b\u6838\u5fc3\u6742\u73af\u7684\u5b98\u80fd\u5316\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u7684\u76f4\u63a5\u9009\u62e9\u6027C3\u70f7\u57fa\u5316\u5177\u6709\u4e00\u5b9a\u7684\u6311\u6218\u6027\uff0c\u56e0\u4e3a\u7b80\u5355\u5364\u4ee3\u70f7\u5728\u8be5\u5408\u6210\u4e0a\u5e76\u4e0d\u9002\u7528\u3002\u540c\u65f6\uff0c\u836f\u7269\u5316\u5b66\u5bb6\u5bf9\u4e8e\u201c\u795e\u5947\u7684\u7532\u57fa\u6548\u5e94\uff08magic methyl effect\uff09\u201d\u7684\u7814\u7a76\u5341\u5206\u611f\u5174\u8da3\uff0c\u56e0\u6b64\u5c06\u7532\u57fa\u5f15\u5165\u4e5f\u662f\u4e00\u9879\u975e\u5e38\u6709\u610f\u4e49\u7684\u5de5\u4f5c\uff0c\u4f46\u662f\u5bf9\u4e8e\u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u7684\u76f4\u63a5C3\u7532\u57fa\u5316\u53cd\u5e94\u4ec5\u6709\u51e0\u4f8b\uff08Scheme 1a\uff09\uff0c\u5176\u4e2d1-\u7532\u57fa\u5432\u54da\u7684\u76f4\u63a5C3\u7532\u57fa\u5316\u66f4\u662f\u4ece\u672a\u62a5\u9053\u3002<\/p>\n

\"\"<\/a><\/p>\n

\uff08\u56fe\u7247\u6765\u6e90\uff1aACS Catalysis<\/em>\uff09<\/p>\n

\u7531\u4e8e\u5177\u6709Lewis\u9178\u6027\uff0c\u787c\u70f7\u50ac\u5316\u5242\u53ef\u5e7f\u6cdb\u7528\u4e8e\u5408\u6210\u8f6c\u5316\u4e2d\uff0c\u901a\u5e38\u7528\u6765\u6d3b\u5316\u6781\u6027\u952e\uff0c\u5176\u4e2d\u4e09\u82b3\u57fa\u787c\u70f7\u4e5f\u53ef\u4ee5\u6d3b\u5316\u975e\u6781\u6027\u952e\u30022002\u5e74\uff0cSantini\u7b49\u4eba\u901a\u8fc7\u4e8c\u7532\u57fa\u82ef\u80fa\u4e0eB(C6<\/sub>F5<\/sub>)3<\/sub>\u5f62\u6210\u4e9a\u80fa\u79bb\u5b50-\u8d1f\u6c22\u787c\u79bb\u5b50\u5bf9\uff0c\u5b9e\u73b0\u4e86\u03b1<\/em>-N C(sp3<\/sup>)-H\u952e\u7684\u5f02\u88c2\uff08Scheme 1b\uff09\u3002\u4e4b\u540e\uff0cB(C6<\/sub>F5<\/sub>)3<\/sub>\u4fc3\u8fdb\u7684\u03b1<\/em>-N C(sp3<\/sup>)-H\u952e\u5f02\u88c2\u4e5f\u9010\u6e10\u88ab\u4f5c\u4e3a\u4e00\u79cd\u5408\u6210\u7b56\u7565\u8fdb\u800c\u8fdb\u884c\u4e86\u76f8\u5173\u5e94\u7528\uff0c\u5982\u4e9a\u80fa\u7684\u8f6c\u79fb\u6c22\u5316\u3001\u542b\u6c2e\u6742\u73af\u7684\u8131\u6c22\u5316\u3001\u751f\u6210\u4e9a\u80fa\u79bb\u5b50\u7528\u4e8eMannich\u578b\u53cd\u5e94\u3001\u7535\u73af\u5316\u53cd\u5e94\u548c\u80fa\u7684\u03b2<\/em>-\u5b98\u80fd\u5316\u53cd\u5e94\u7b49\u7b49\uff0c\u4f46\u5229\u7528\u8be5\u53cd\u5e94\u6027\u5b9e\u73b0\u50ac\u5316\u6784\u5efaC-C\u952e\u7684\u53cd\u5e94\u4ecd\u7136\u5f88\u5c11\u3002\u53d7\u4e0a\u8ff0\u6587\u732e\u7684\u542f\u53d1\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u5177\u6709\u6311\u6218\u6027\u7684\u70f7\u57fa\u5316\u53cd\u5e94\u7684\u63a2\u7d22\uff0c\u5229\u7528\u4e09\u82b3\u57fa\u787c\u70f7\u4fc3\u8fdb\u03b1<\/em>-N C-H\u952e\u5f02\u88c2\u4ee5\u6d3b\u5316\u80fa\u884d\u751f\u7684\u70f7\u57fa\u5316\u8bd5\u5242\uff0c\u5b9e\u73b0\u4e86\u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u7684\u76f4\u63a5C3\u70f7\u57fa\u5316\u53cd\u5e94\uff08Scheme 1c\uff09\u3002\u5229\u7528\u8fd9\u79cd\u787c\u70f7\u50ac\u5316\u7684\u65b9\u6cd5\uff0c\u5e38\u89c1\u7684\u4e00\u4e9b\u526f\u53cd\u5e94\u5982\u5432\u54da\u7684N<\/em>-\u7532\u57fa\u5316\u30013,3\u2019-\u4e8c\u5432\u54da\u7532\u70f7\u7684\u5f62\u6210\u548c\u6c27\u5316\u5432\u54da\u7684\u53cc\u70f7\u57fa\u5316\u5747\u672a\u53d1\u73b0\uff0c\u5e95\u7269\u8303\u56f4\u4e5f\u5f88\u5e7f\u6cdb\uff0c\u5305\u62ec1-\u30012-\u548c1,2-\u53d6\u4ee3\u7684\u5432\u54da\u548c\u65b0\u578b\u7684\u70f7\u57fa\u5316\/\u5f00\u73af\u53cd\u5e94\u3002<\/p>\n

\u9996\u5148\uff0c\u4f5c\u8005\u5bf9\u7532\u57fa\u5316\u8bd5\u5242\u8fdb\u884c\u4e86\u7b5b\u9009\uff08Scheme 2\uff09\u3002\u7b5b\u9009\u7ed3\u679c\u8868\u660e\uff0c\u5bcc\u7535\u5b50\u7684\u4e8c\u82b3\u57fa\u7532\u57fa\u80fa\u59824a<\/strong>\u548c6a<\/strong>\u53ef\u5728\u5ba4\u6e29\u4e0b\u83b7\u5f97\u51e0\u4e4e\u5b9a\u91cf\u6536\u7387\u7684\u4ea7\u72692a<\/strong>\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u4e86\u8003\u5bdf\uff0c\u5305\u62ec1-\u30012-\u548c1,2-\u53d6\u4ee3\u7684\u5432\u54da\u548c\u6c27\u5316\u5432\u54da\uff08Scheme 3\uff09\u3002\u53cd\u5e94\u7ed3\u679c\u8868\u660e\uff0c\u8be5\u53cd\u5e94\u5177\u6709\u5e7f\u6cdb\u7684\u5e95\u7269\u8303\u56f4\uff0c\u5404\u79cd\u5b98\u80fd\u56e2\u548c\u53d6\u4ee3\u6a21\u5f0f\u5747\u80fd\u5f88\u597d\u5730\u517c\u5bb9\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u8be5\u65b9\u6848\u4e0b\uff0c\u4e5f\u53ef\u5b9e\u73b01-\u7532\u57fa\u5432\u54da1f<\/strong>\u7684\u76f4\u63a5\u7532\u57fa\u5316\uff08\u4e4b\u524d\u6ca1\u6709\u6587\u732e\u62a5\u9053\uff09\u3002\u542bNH\u7684\u5432\u54da\u4e5f\u80fd\u88ab\u9ad8\u6548\u5730\u7532\u57fa\u5316\uff0c\u540c\u65f6\u5e76\u672a\u53d1\u73b0N<\/em>-\u7532\u57fa\u5316\u526f\u4ea7\u7269\u30023,3\u2019-\u4e8c\u5432\u54da\u7532\u70f7\u526f\u4ea7\u7269\uff0c\u53ef\u7531\u4e9a\u80fa\u79bb\u5b50\u4eb2\u7535\u8bd5\u5242\u4e0e\u5432\u54da\u5f62\u6210\uff0c\u4e5f\u672a\u53d1\u73b0\u3002\u6c27\u5316\u5432\u54da\u5728\u8fdb\u884c\u7532\u57fa\u5316\u65f6\u4e5f\u6ca1\u6709\u53d1\u73b0C3\u53cc\u7532\u57fa\u5316\u526f\u4ea7\u7269\u30026-\u7532\u57fa\u5432\u54da2n<\/strong>\u548c\u65e0\u53d6\u4ee3\u7684\u6c27\u5316\u5432\u54da9n<\/strong>\u8fdb\u884c\u7532\u57fa\u5316\u4ea7\u7387\u5f88\u4f4e\uff0c\u53ef\u80fd\u662f\u7531\u4e8eN\u6216O\u4e0eB(C6<\/sub>F5<\/sub>)3<\/sub>\u50ac\u5316\u5242\u914d\u4f4d\u7684\u7ade\u4e89\u5bfc\u81f4\u3002\u53e6\u5916\uff0c\u8fd8\u6210\u529f\u5b9e\u73b0\u4e861,2-\u4e8c\u7532\u57fa\u5432\u54da1a<\/strong>\u7684C3\u4e59\u57fa\u5316\uff0810a<\/strong>\uff09\u3001\u7678\u57fa\u5316\uff0811a<\/strong>\uff09\u548c\u82c4\u57fa\u5316\uff0812a<\/strong>\uff09\u3002<\/p>\n

\"\"<\/a><\/p>\n

\uff08\u56fe\u7247\u6765\u6e90\uff1aACS Catalysis<\/em>\uff09<\/p>\n

\u787c\u70f7\u50ac\u5316\u5242B(C6<\/sub>F5<\/sub>)3<\/sub>\u6613\u5438\u6c34\u53d7\u6f6e\u53d8\u4e3aH2<\/sub>O\u00b7B(C6<\/sub>F5<\/sub>)3<\/sub>\uff0c\u56e0\u6b64\u9700\u8981\u5728\u60f0\u6027\u6c14\u4f53\u4fdd\u62a4\u4e0b\u64cd\u4f5c\u3002\u800c\u4f5c\u8005\u4f7f\u7528H2<\/sub>O\u00b7B(C6<\/sub>F5<\/sub>)3<\/sub>\uff0c\u518d\u6dfb\u52a0\u50ac\u5316\u91cf\u7684\u4e09\u4e59\u57fa\u7845\u70f7\uff0c\u4e5f\u80fd\u4ee5\u826f\u597d\u7684\u6536\u7387\u5b9e\u73b0\u5432\u54da\u548c\u6c27\u5316\u5432\u54da\u7684\u70f7\u57fa\u5316\uff08Scheme 4\uff09\uff0c\u4f53\u73b0\u4e86\u8be5\u65b9\u6cd5\u65e0\u9700\u7279\u6b8a\u88c5\u7f6e\uff08\u5982\u624b\u5957\u7bb1\uff09\uff0c\u4e0d\u9700\u8981\u5bf9\u787c\u70f7\u50ac\u5316\u5242\u8fdb\u884c\u5206\u79bb\u7eaf\u5316\uff0c\u4e0d\u9700\u8981\u4e25\u683c\u5e72\u71e5\u6eb6\u5242\u7684\u4f18\u70b9\u3002<\/p>\n

\"\"<\/a><\/p>\n

\uff08\u56fe\u7247\u6765\u6e90\uff1aACS Catalysis<\/em>\uff09<\/p>\n

\u9664\u4e86\u7532\u57fa\u5316\u548c\u70f7\u57fa\u5316\uff0c\u4f5c\u8005\u8fd8\u63a2\u7d22\u4e86B(C6<\/sub>F5<\/sub>)3<\/sub>\u50ac\u5316\u7684\u70f7\u57fa\u5316\/\u5f00\u73af\u4e32\u8054\u53cd\u5e94\uff08Scheme 5\uff09\uff0c\u4ee5\u826f\u597d\u7684\u6536\u7387\u5f97\u5230\u4e86\u542b4-(3-\u5432\u54da)\u4e01\u80fa\u7ed3\u6784\u7684\u4ea7\u726915<\/strong>\uff0c\u8be5\u4ea7\u7269\u7ed3\u6784\u5b58\u5728\u4e8e\u51e0\u79cd\u91cd\u8981\u7684\u8840\u6e05\u7d20\u548c\u591a\u5df4\u80fa\u836f\u7269\u5206\u5b50\u4e2d\u3002<\/p>\n

\"\"<\/a><\/p>\n

\uff08\u56fe\u7247\u6765\u6e90\uff1aACS Catalysis<\/em>\uff09<\/p>\n

\u4e3a\u4e86\u8fdb\u4e00\u6b65\u4e86\u89e3\u53cd\u5e94\u7684\u673a\u7406\uff0c\u4f5c\u8005\u4f7f\u75281a<\/strong>\u30011l<\/strong>\u548c\u6c18\u4ee3\u7532\u57fa\u5316\u8bd5\u52426a<\/strong>–d<\/em>3<\/sub>\u8fdb\u884c\u4e86\u6c18\u4ee3\u5b9e\u9a8c\uff0c\u4ee5\u9ad8\u4ea7\u7387\u5f97\u5230\u4e86\u76f8\u5e94\u7684\u6c18\u4ee3\u4ea7\u72692a<\/strong>–d<\/em>3<\/sub>\u548c2l<\/strong>–d<\/em>3<\/sub>\uff08Scheme 6a\uff09\u3002\u57fa\u4e8e\u4ee5\u4e0a\u5b9e\u9a8c\u548c\u76f8\u5173\u6587\u732e\u7684\u67e5\u9605\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86B(C6<\/sub>F5<\/sub>)3<\/sub>\u50ac\u5316\u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u7684\u76f4\u63a5C3\u70f7\u57fa\u5316\u53cd\u5e94\u53ef\u80fd\u7684\u673a\u7406\uff08Scheme 6b\uff09\uff1a\uff08i\uff09\u787c\u70f7\u50ac\u5316\u5242\u652b\u53d6\u8d1f\u6c22\uff0c\u4f7f\u80fa\u884d\u751f\u7684\u70f7\u57fa\u5316\u8bd5\u5242\u53d1\u751f\u03b1<\/em>-N C(sp3<\/sup>)-H\u952e\u7684\u5f02\u88c2\uff0c\u5f62\u6210\u4e9a\u80fa\u79bb\u5b50-\u8d1f\u6c22\u787c\u79bb\u5b50\u5bf916<\/strong>\uff1b\uff08ii\uff09\u4eb2\u7535\u4e9a\u80fa\u79bb\u5b5016<\/strong>\u901a\u8fc7\u7c7b\u4f3cMannich\u53cd\u5e94\u8fc7\u7a0b\u4e0e\u5432\u54da1<\/strong>\uff08\u6216\u6c27\u5316\u5432\u54da8<\/strong>\uff09\u53cd\u5e94\u5f62\u6210\u65b0\u7684C-C\u952e\uff1b\uff08iii\uff09\u79bb\u5b50\u5bf917<\/strong>\u4ee5E1CB<\/sub>\u578b\u673a\u7406\u6d88\u9664\u4e00\u5206\u5b50\u80fa18<\/strong>\uff1b\uff08iv\uff09\u542b\u03b1<\/em>,\u03b2<\/em>-\u4e0d\u9971\u548c\u4e9a\u80fa\u79bb\u5b50\u7684\u79bb\u5b50\u5bf919<\/strong>\u88ab\u8d1f\u6c22\u787c\u9634\u79bb\u5b50\u8fd8\u539f\uff0c\u5f97\u5230\u70f7\u57fa\u5316\u7684\u5432\u54da2<\/strong>\uff08\u6216\u6c27\u5316\u5432\u54da9<\/strong>\uff09\uff0c\u50ac\u5316\u5242\u518d\u751f\u3002\u5728\u787c\u70f7\u50ac\u5316\u7684\u70f7\u57fa\u5316\/\u5f00\u73af\u4e32\u8054\u53cd\u5e94\u4e2d\uff0c\u7531\u4e8e\u4e9a\u80fa\u79bb\u5b5020<\/strong>\u7684\u73af\u7ed3\u6784\u7279\u6027\uff0c\u4f7f\u80fa\u90e8\u5206\u5728\u6d88\u9664\u540e\u5f97\u4ee5\u4fdd\u7559\u5728\u4ea7\u726915<\/strong>\u4e2d\uff08Scheme 6c\uff09\u3002<\/p>\n

\"\"<\/a><\/p>\n

\uff08\u56fe\u7247\u6765\u6e90\uff1aACS Catalysis<\/em>\uff09<\/p>\n

\u603b\u7ed3<\/h4>\n

\u82f1\u56fd\u83b1\u65af\u7279\u5927\u5b66Alexander P. Pulis\u4e0e\u82f1\u56fd\u5361\u8fea\u592b\u5927\u5b66Louis C. Morrill\u548cRebecca L. Melen\u8bfe\u9898\u7ec4\u5f00\u53d1\u4e86\u4e00\u79cd\u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u76f4\u63a5C3\u70f7\u57fa\u5316\u7684\u65b0\u65b9\u6cd5\u3002\u4f7f\u7528B(C6<\/sub>F5<\/sub>)3<\/sub>\u50ac\u5316\u5242\u548c\u80fa\u884d\u751f\u7684\u70f7\u57fa\u5316\u8bd5\u5242\uff0c\u63a2\u7d22\u4e86\u787c\u70f7\u4fc3\u8fdb\u03b1<\/em>-N C-H\u952e\u5f02\u88c2\u7684\u7279\u6027\u5728\u50ac\u5316C-C\u952e\u5f62\u6210\u53cd\u5e94\u4e2d\u7684\u5e94\u7528\u3002\u8be5\u65b9\u6cd5\u5177\u6709\u65e0\u9700\u91d1\u5c5e\u50ac\u5316\u5242\u7684\u4f7f\u7528\u3001\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\uff081-\u30012-\u548c1,2-\u53d6\u4ee3\u7684\u5432\u54da\u5747\u80fd\u5f88\u597d\u5730\u76f4\u63a5\u7532\u57fa\u5316\uff09\u3001\u5316\u5b66\u9009\u62e9\u6027\u597d\uff08\u907f\u514d\u4e86N<\/em>-\u7532\u57fa\u5316\u30013,3\u2019-\u4e8c\u5432\u54da\u7532\u70f7\u3001\u6c27\u5316\u5432\u54daC3\u53cc\u7532\u57fa\u5316\u526f\u4ea7\u7269\u7684\u5f62\u6210\uff09\u7b49\u4f18\u70b9\u3002\u540c\u65f6\uff0c\u8fd8\u6210\u529f\u5730\u5e94\u7528\u4e8e\u70f7\u57fa\u5316\/\u5f00\u73af\u4e32\u8054\u53cd\u5e94\u4e2d\u3002<\/p>\n

\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u6709\u673a\u5c0f\u767d \u5bfc\u8bfb \u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u7684\u76f4\u63a5C3\u70f7\u57fa\u5316\u662f\u4e00\u4e2a\u975e\u5e38\u5177\u6709\u6311\u6218\u6027\u7684\u53cd\u5e94\uff0c\u8fc4\u4eca\u7684\u76f8\u5173\u62a5\u9053\u4e5f\u975e\u5e38\u5c11\u3002\u6700\u8fd1\uff0c\u82f1\u56fd\u83b1\u65af\u7279\u5927\u5b66Alexander P. Pulis\u4e0e\u82f1\u56fd\u5361\u8fea\u592b\u5927\u5b66Louis C. Morrill\u548cRebecca L. Melen\u8bfe\u9898\u7ec4\u5229\u7528\u4e09\u82b3\u57fa\u787c\u70f7\u80fd\u591f\u4fc3\u8fdb\u80fa\u4e2d\u03b1-N C-H\u952e\u5f02\u88c2\u7684\u7279\u6027\uff0c\u5e76\u4f7f\u7528\u4e00\u79cd\u80fa\u884d\u751f\u7684\u70f7\u57fa\u5316\u8bd5\u5242\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u4e00\u7cfb\u5217\u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u7684\u76f4\u63a5C3\u70f7\u57fa\u5316\u53cd\u5e94\u3002\u53e6\u5916\uff0c\u4ed6\u4eec\u8fd8\u5c06\u8fd9\u79cd\u787c\u70f7\u50ac\u5316\u7684\u7b56\u7565\u5e94\u7528\u5230\u4e86\u70f7\u57fa\u5316\/\u5f00\u73af\u4e32\u8054\u53cd\u5e94\u4e4b\u4e2d\u3002 B(C6F5)3-Catalyzed Direct C3 Alkylation of Indoles and Oxindoles Shyam Basak, Ana Alvarez-Montoya, Laura Winfrey, Rebecca L. Melen,* Louis C. Morrill,* and Alexander P. Pulis* ACS Catal. 2020, 10, 4835-4840\u00a0 DOI: 10.1021\/acscatal.0c01141 \uff08\u56fe\u7247\u6765\u6e90\uff1aACS Catalysis\uff09 \u6b63\u6587 \u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u662f\u751f\u7269\u6d3b\u6027\u5206\u5b50\u4e2d\u7684\u91cd\u8981\u7ed3\u6784\u3002\u7ecf\u5178\u7684\u5432\u54da\u5408\u6210\u65b9\u6cd5\u6d89\u53ca\u73af\u7684\u6784\u5efa\uff0c\u5176\u5b83\u4e00\u4e9b\u65b9\u6cd5\u4e5f\u53ea\u662f\u6d89\u53ca\u8fd9\u4e9b\u6838\u5fc3\u6742\u73af\u7684\u5b98\u80fd\u5316\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u7684\u76f4\u63a5\u9009\u62e9\u6027C3\u70f7\u57fa\u5316\u5177\u6709\u4e00\u5b9a\u7684\u6311\u6218\u6027\uff0c\u56e0\u4e3a\u7b80\u5355\u5364\u4ee3\u70f7\u5728\u8be5\u5408\u6210\u4e0a\u5e76\u4e0d\u9002\u7528\u3002\u540c\u65f6\uff0c\u836f\u7269\u5316\u5b66\u5bb6\u5bf9\u4e8e\u201c\u795e\u5947\u7684\u7532\u57fa\u6548\u5e94\uff08magic methyl effect\uff09\u201d\u7684\u7814\u7a76\u5341\u5206\u611f\u5174\u8da3\uff0c\u56e0\u6b64\u5c06\u7532\u57fa\u5f15\u5165\u4e5f\u662f\u4e00\u9879\u975e\u5e38\u6709\u610f\u4e49\u7684\u5de5\u4f5c\uff0c\u4f46\u662f\u5bf9\u4e8e\u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u7684\u76f4\u63a5C3\u7532\u57fa\u5316\u53cd\u5e94\u4ec5\u6709\u51e0\u4f8b\uff08Scheme 1a\uff09\uff0c\u5176\u4e2d1-\u7532\u57fa\u5432\u54da\u7684\u76f4\u63a5C3\u7532\u57fa\u5316\u66f4\u662f\u4ece\u672a\u62a5\u9053\u3002 \uff08\u56fe\u7247\u6765\u6e90\uff1aACS Catalysis\uff09 \u7531\u4e8e\u5177\u6709Lewis\u9178\u6027\uff0c\u787c\u70f7\u50ac\u5316\u5242\u53ef\u5e7f\u6cdb\u7528\u4e8e\u5408\u6210\u8f6c\u5316\u4e2d\uff0c\u901a\u5e38\u7528\u6765\u6d3b\u5316\u6781\u6027\u952e\uff0c\u5176\u4e2d\u4e09\u82b3\u57fa\u787c\u70f7\u4e5f\u53ef\u4ee5\u6d3b\u5316\u975e\u6781\u6027\u952e\u30022002\u5e74\uff0cSantini\u7b49\u4eba\u901a\u8fc7\u4e8c\u7532\u57fa\u82ef\u80fa\u4e0eB(C6F5)3\u5f62\u6210\u4e9a\u80fa\u79bb\u5b50-\u8d1f\u6c22\u787c\u79bb\u5b50\u5bf9\uff0c\u5b9e\u73b0\u4e86\u03b1-N C(sp3)-H\u952e\u7684\u5f02\u88c2\uff08Scheme 1b\uff09\u3002\u4e4b\u540e\uff0cB(C6F5)3\u4fc3\u8fdb\u7684\u03b1-N C(sp3)-H\u952e\u5f02\u88c2\u4e5f\u9010\u6e10\u88ab\u4f5c\u4e3a\u4e00\u79cd\u5408\u6210\u7b56\u7565\u8fdb\u800c\u8fdb\u884c\u4e86\u76f8\u5173\u5e94\u7528\uff0c\u5982\u4e9a\u80fa\u7684\u8f6c\u79fb\u6c22\u5316\u3001\u542b\u6c2e\u6742\u73af\u7684\u8131\u6c22\u5316\u3001\u751f\u6210\u4e9a\u80fa\u79bb\u5b50\u7528\u4e8eMannich\u578b\u53cd\u5e94\u3001\u7535\u73af\u5316\u53cd\u5e94\u548c\u80fa\u7684\u03b2-\u5b98\u80fd\u5316\u53cd\u5e94\u7b49\u7b49\uff0c\u4f46\u5229\u7528\u8be5\u53cd\u5e94\u6027\u5b9e\u73b0\u50ac\u5316\u6784\u5efaC-C\u952e\u7684\u53cd\u5e94\u4ecd\u7136\u5f88\u5c11\u3002\u53d7\u4e0a\u8ff0\u6587\u732e\u7684\u542f\u53d1\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u5177\u6709\u6311\u6218\u6027\u7684\u70f7\u57fa\u5316\u53cd\u5e94\u7684\u63a2\u7d22\uff0c\u5229\u7528\u4e09\u82b3\u57fa\u787c\u70f7\u4fc3\u8fdb\u03b1-N C-H\u952e\u5f02\u88c2\u4ee5\u6d3b\u5316\u80fa\u884d\u751f\u7684\u70f7\u57fa\u5316\u8bd5\u5242\uff0c\u5b9e\u73b0\u4e86\u5432\u54da\u4e0e\u6c27\u5316\u5432\u54da\u7684\u76f4\u63a5C3\u70f7\u57fa\u5316\u53cd\u5e94\uff08Scheme 1c\uff09\u3002\u5229\u7528\u8fd9\u79cd\u787c\u70f7\u50ac\u5316\u7684\u65b9\u6cd5\uff0c\u5e38\u89c1\u7684\u4e00\u4e9b\u526f\u53cd\u5e94\u5982\u5432\u54da\u7684N-\u7532\u57fa\u5316\u30013,3\u2019-\u4e8c\u5432\u54da\u7532\u70f7\u7684\u5f62\u6210\u548c\u6c27\u5316\u5432\u54da\u7684\u53cc\u70f7\u57fa\u5316\u5747\u672a\u53d1\u73b0\uff0c\u5e95\u7269\u8303\u56f4\u4e5f\u5f88\u5e7f\u6cdb\uff0c\u5305\u62ec1-\u30012-\u548c1,2-\u53d6\u4ee3\u7684\u5432\u54da\u548c\u65b0\u578b\u7684\u70f7\u57fa\u5316\/\u5f00\u73af\u53cd\u5e94\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u5bf9\u7532\u57fa\u5316\u8bd5\u5242\u8fdb\u884c\u4e86\u7b5b\u9009\uff08Scheme 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