{"id":33277,"date":"2020-07-04T08:05:23","date_gmt":"2020-07-04T00:05:23","guid":{"rendered":"\/\/www.gsbet888.com\/?p=33277"},"modified":"2020-06-29T22:52:46","modified_gmt":"2020-06-29T14:52:46","slug":"fabien-gagosz","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/%e4%b8%96%e7%95%8c%e9%9d%92%e5%b9%b4%e5%8c%96%e5%ad%a6%e5%ae%b6\/2020\/07\/fabien-gagosz.html","title":{"rendered":"Fabien Gagosz"},"content":{"rendered":"<p>\u672c\u6587\u4f5c\u8005 \u77f3\u6cb9\u919a<\/p>\n<h4><strong>\u6982\u8981<\/strong><\/h4>\n<p>Fabien Gagosz, \u6e25\u592a\u534e\u5927\u5b66\u5316\u5b66\u4e0e\u751f\u7269\u5206\u5b50\u79d1\u5b66\u7cfb\u6559\u6388\uff0c\u6709\u673a\u5316\u5b66\u5bb6\u3002\u8bfe\u9898\u7ec4\u4e3b\u9875\uff1a<a href=\"https:\/\/www.thegagoszgroup.com\/\">https:\/\/www.thegagoszgroup.com\/<\/a><\/p>\n<h4><strong>\u7ecf\u5386<\/strong><\/h4>\n<ul>\n<li>1994-1997\u5e74 \u65af\u7279\u62c9\u65af\u5821\u5927\u5b66\u83b7\u5f97\u5b66\u58eb\u5b66\u4f4d<\/li>\n<li>1997\u5e74 \u6cd5\u56fd\u8def\u6613\u65af-\u5df4\u65af\u5fb7\u5927\u5b66DEA\uff08Dr. C. Mioskowski\uff09<\/li>\n<li>1998-2002\u5e74 \u5df4\u9ece\u7efc\u5408\u7406\u5de5\u5927\u5b66\u83b7\u5f97\u535a\u58eb\uff08Prof. S. Z. Zard\uff09<\/li>\n<li>2003-2004\u5e74 \u4f26\u6566\u5927\u5b66\u535a\u58eb\u540e\uff08Prof. W. B. Motherwell\uff09<\/li>\n<li>2004-2007\u5e74 \u5df4\u9ece\u7efc\u5408\u7406\u5de5\u5927\u5b66CNRS\u7814\u7a76\u5458\uff08CR2\uff09<\/li>\n<li>2007-2012\u5e74 \u5df4\u9ece\u7efc\u5408\u7406\u5de5\u5927\u5b66CNRS\u7814\u7a76\u5458\uff08CR1\uff09<\/li>\n<li>2012-2016\u5e74 \u5df4\u9ece\u7efc\u5408\u7406\u5de5\u5927\u5b66CNRS\u7814\u7a76\u5458\uff08DR2\uff09<\/li>\n<li>2016-\u81f3\u4eca\u00a0 \u00a0\u6e25\u592a\u534e\u5927\u5b66\u6b63\u6559\u6388<\/li>\n<\/ul>\n<h4><strong>\u83b7\u5956\u7ecf\u5386<\/strong><\/h4>\n<ul>\n<li>2013 Junior Distinguished Member of the French Chemical Society<\/li>\n<li>2012 ACROS award for young investigator from the French Chemical Society<\/li>\n<li>2010 Thieme Chemistry Journal Award<\/li>\n<li>2008 CNRS Bronze Medal Award<\/li>\n<li>2003 Dina Surdin Ph.D. Thesis Award from the French Chemical Society<\/li>\n<li>2002 &#8220;Roche Symposium for Leading Chemists of the Next Decade&#8221; Award<\/li>\n<\/ul>\n<h4><strong>\u7814\u7a76\u65b9\u5411<\/strong><\/h4>\n<p>Fabien Gagosz\u6559\u6388\u7684\u7814\u7a76\u5174\u8da3\u96c6\u4e2d\u5728\u8bbe\u8ba1\u65b0\u7684\u50ac\u5316\u65b9\u6cd5\u5b66\uff0c\u5e76\u5c06\u5176\u7528\u4e8e\u5f00\u53d1\u5404\u79cd\u611f\u5174\u8da3\u7684\u5206\u5b50\u7ed3\u6784\u5408\u6210\u3002\u8bfe\u9898\u7ec4\u7814\u7a76\u8ba1\u5212\u4e13\u6ce8\u4e8e\u65b0\u50ac\u5316\u53cd\u5e94\u7684\u8bbe\u8ba1\u548c\u65b0\u5408\u6210\u65b9\u6cd5\u7684\u5f00\u53d1\uff0c\u7279\u522b\u5173\u6ce8\u548c\u504f\u7231\u540e\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u548c\u91d1\u7684\u5747\u76f8\u50ac\u5316\u3002<\/p>\n<p><strong><span style=\"color: #0000ff;\">1. \u91d1\u50ac\u5316<\/span><\/strong><\/p>\n<p>\u91d1\u7684\u5747\u76f8\u50ac\u5316\u662f\u4e00\u79cd\u53ef\u6709\u6548\u5730\u4f7f\u78b3-\u03c0\u4f53\u7cfb\u5b98\u80fd\u56e2\u5316\u5e76\u4e3a\u5206\u5b50\u590d\u6742\u6027\u548c\u591a\u6837\u6027\u751f\u6210\u7684\u4e00\u79cd\u7279\u5b9a\u4e14\u529f\u80fd\u5f3a\u5927\u7684\u5408\u6210\u65b9\u6cd5\u3002\u4eb2\u7535\u7684\u91d1\u7edc\u5408\u7269\u5728\u5176\u4ed6\u5b98\u80fd\u56e2\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\u9009\u62e9\u6027\u4e0e\u7094\u70c3\u6216\u8054\u70ef\u7ed3\u5408\uff0c\u5e76\u901a\u8fc7\u591a\u79cd\u4eb2\u6838\u7269\u8d28\u6fc0\u6d3b\u5b83\u4eec\u5b9e\u73b0\u5b98\u80fd\u56e2\u5316\u7684\u80fd\u529b\uff0c\u4e3a\u53d1\u73b0\u65b0\u7684\u8f6c\u5316\u63d0\u4f9b\u4e86\u72ec\u6b8a\u7684\u673a\u4f1a\u3002\u9664\u4e86\u4f5c\u4e3aLewis\u9178\u4e4b\u5916\uff0c\u91d1\u8fd8\u53ef\u80fd\u4f5c\u4e3a\u7535\u5b50\u4f9b\u4f53\uff0c\u4ece\u800c\u4f7f\u4e2d\u95f4\u9633\u79bb\u5b50\u7269\u79cd\u7a33\u5b9a\u3002\u91d1\u914d\u5408\u7269\u8fd8\u5177\u6709\u65e0\u6bd2\u3001\u8010\u6c27\u548c\u4e0e\u6c34\u73af\u5883\u76f8\u5bb9\u7684\u7279\u6027\uff0c\u56e0\u6b64\u53ef\u4ee5\u5728\u73af\u5883\u53cb\u597d\u7684\u5de5\u4e1a\u8fc7\u7a0b\u548c\u5b9e\u9645\u64cd\u4f5c\u4e2d\u5177\u6709\u6f5c\u5728\u5e94\u7528\u3002Gagosz\u8bfe\u9898\u7ec4\u6b63\u5728\u5229\u7528\u4eb2\u7535\u91d1\u7edc\u5408\u7269\u7684\u72ec\u7279\u53cd\u5e94\u6027\u6765\u53d1\u73b0\u53ef\u80fd\u9002\u7528\u4e8e\u6709\u673a\u5408\u6210\u5404\u4e2a\u9886\u57df\u7684\u65b0\u9896\u6709\u673a\u5316\u5b66\u53cd\u5e94\uff08scheme 1\uff09\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-25.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33278 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-25.jpg\" alt=\"\" width=\"739\" height=\"400\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-25.jpg 739w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-25-300x162.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-25-680x368.jpg 680w\" sizes=\"(max-width: 739px) 100vw, 739px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 1 \u91d1\u50ac\u5316<\/p>\n<p><strong>1.1 \u65b0\u578b\u91d1\u50ac\u5316\u5242<\/strong><\/p>\n<p>\u4e3a\u4e86\u63d0\u9ad8\u53cd\u5e94\u7684\u6548\u7387\u548c\u9009\u62e9\u6027\uff0c\u5f00\u53d1\u65b0\u53cd\u5e94\u6027\u5e76\u8c03\u8282\u5408\u6210\u8f6c\u5316\u4e2d\u91d1\u4e2d\u95f4\u4f53\u7684\u4f5c\u7528\uff0c\u65b0\u7684\u91d1\u50ac\u5316\u5242\u7684\u5408\u6210\u81f3\u5173\u91cd\u8981\u3002Gagosz\u5c0f\u7ec4\u5728\u8fd9\u4e00\u9886\u57df\u5f88\u6d3b\u8dc3\uff0c\u5df2\u7ecf\u5f00\u53d1\u4e86\u591a\u4e2a\u91d1(I)\u914d\u5408\u7269\u5bb6\u65cf\uff08scheme 2\uff09\uff0c\u5e76\u4e14\u5df2\u88ab\u8be5\u9886\u57df\u7684\u7814\u7a76\u5c0f\u7ec4\u5e7f\u6cdb\u4f7f\u7528<sup>1-3<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-19.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33279 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-19.jpg\" alt=\"\" width=\"600\" height=\"306\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-19.jpg 600w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-19-300x153.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 2 \u65b0\u578b\u91d1\u50ac\u5316\u5242<\/p>\n<p><strong>1.2 \u73af\u5316<\/strong><strong>&#8211;<\/strong><strong>\u591a\u91cd\u952e\u5f62\u6210\u8f6c\u5316<\/strong><\/p>\n<p>\u901a\u8fc7\u5229\u7528\u91d1\u7269\u79cd\u4eb2\u7535\u7684\u72ec\u7279\u53cd\u5e94\u6027\uff0cGagosz\u6559\u6388\u56e2\u961f\u8bbe\u8ba1\u5e76\u5f00\u53d1\u4e86\u80fd\u591f\u5728\u4e00\u6b21\u53cd\u5e94\u4e2d\u4ee5\u7acb\u4f53\u9009\u62e9\u6027\u7684\u65b9\u5f0f\u5f62\u6210\u591a\u4e2aC-C\u6216C-\u6742\u539f\u5b50\u952e\u7684\u50ac\u5316\u8fc7\u7a0b<sup>4-8<\/sup>\uff08Scheme 3\uff09\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-17.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33280 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-17.jpg\" alt=\"\" width=\"700\" height=\"349\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-17.jpg 700w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-17-300x150.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-17-680x339.jpg 680w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 3\u73af\u5316-\u591a\u91cd\u952e\u5f62\u6210\u8f6c\u5316<\/p>\n<p><strong>1.3 <\/strong><strong>\u6c2e\u5bbe\u8f6c\u79fb\u5230\u78b3\u03c0<\/strong><strong>&#8211;<\/strong><strong>\u7cfb\u7edf<\/strong><\/p>\n<p>\u91d1\u50ac\u5316\u53cd\u5e94\u4e2d\uff0c\u5177\u6709\u79bb\u5b50\u5316\u57fa\u56e2\u7684\u6c2e\u4eb2\u6838\u914d\u5408\u7269\u53ef\u4ee5\u5728\u78b3\u03c0-\u4f53\u7cfb\u4e0a\u8f6c\u79fb\u6c2e\u5bbe\u5316\u5408\u7269\u3002Gagosz\u8bfe\u9898\u7ec4\u5229\u7528\u8fd9\u79cd\u7c7b\u578b\u7684\u53cd\u5e94\u6765\u5f00\u53d1\u80fd\u591f\u4ee5\u7094\u70c3\u548c\u8054\u70ef\u57fa\u56e2\u4f5c\u4e3a\u5e95\u7269\u7684\u6c28\u57fa\u5b98\u80fd\u56e2\u5316\u5408\u6210\u5404\u79cd\u6c2e\u6742\u73af\u7684\u65b9\u6cd5<sup>9-14<\/sup>\uff08Scheme 4\uff09\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-17.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33281 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-17.jpg\" alt=\"\" width=\"680\" height=\"316\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-17.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-17-300x139.jpg 300w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 4 \u6c2e\u5bbe\u8f6c\u79fb\u5230\u78b3\u03c0-\u7cfb\u7edf<\/p>\n<p><span style=\"color: #0000ff;\"><strong>2. \u6c22\u8f6c\u79fb\u8fc7\u7a0b<\/strong><\/span><\/p>\n<p>\u6c22\u8f6c\u79fb\uff0c\u65e0\u8bba\u662f\u5728\u4eb2\u7535\u6d3b\u5316\u4e0b\u4ee5\u6c22\u5316\u7269\uff08H-\uff09\u5f62\u5f0f\u8fd8\u662f\u5728\u6c22\u81ea\u7531\u57fa\uff08H\u2219\uff09\u4e2d\u5f62\u5f0f\uff0c\u90fd\u662f\u4f7f\u6709\u673a\u5206\u5b50\u5b98\u80fd\u5316\u5e76\u589e\u52a0\u5176\u7ed3\u6784\u590d\u6742\u6027\u7684\u6709\u7528\u65b9\u6cd5\u3002\u5c3d\u7ba1\u591a\u5e74\u6765\u5df2\u7ecf\u62a5\u9053\u4e86\u6d89\u53ca\u8fd9\u4e9b\u8fc7\u7a0b\u7684\u8bb8\u591a\u8f6c\u5316\uff0c\u4f46\u662f\u8fd9\u79cd\u53cd\u5e94\u4ecd\u7136\u6ca1\u6709\u5728\u5408\u6210\u65b9\u6cd5\u7684\u80cc\u666f\u4e0b\u5f97\u5230\u5145\u5206\u7684\u5229\u7528\u3002\u4f7f\u7528\u91d1\u50ac\u5316\u6216\u81ea\u7531\u57fa\u5316\u5b66\u8bbe\u8ba1\u548c\u5f00\u53d1\u4e86\u78b3-\u03c0\u7cfb\u7edf\uff08\u70ef\u70c3\uff0c\u7094\u70c3\uff0c\u8054\u70ef\uff09\u52a0\u6c22\u5b98\u80fd\u5316\u548cC-H\u952e\u5b98\u80fd\u56e2\u5316\u7684\u8f6c\u5316\uff08scheme 5\uff09\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/5-13.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33282 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/5-13.jpg\" alt=\"\" width=\"680\" height=\"174\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/5-13.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/5-13-300x77.jpg 300w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 5\u6c22\u8f6c\u79fb\u8fc7\u7a0b<\/p>\n<p><strong>2.1 <\/strong><strong>\u6c22\u8f6c\u79fb\u8fc7\u7a0b<\/strong><\/p>\n<p>\u91d1\u7684\u50ac\u5316\u4f5c\u7528\u53ef\u4ee5\u4ea7\u751f\u9ad8\u5ea6\u4eb2\u7535\u7684\u4e2d\u95f4\u4ea7\u7269\uff0c\u662f\u8fdb\u884c\u6c22\u5316\u7269\u8f6c\u79fb\u7684\u4e00\u4e2a\u7279\u522b\u6709\u7528\u7684\u5de5\u5177\u3002Gagosz\u6559\u6388\u5c0f\u7ec4\u5229\u7528\u8fd9\u4e00\u7279\u6027\u5728\u91d1\u6d3b\u5316\u7684\u7094\u70c3\u4e0e\u4e19\u4e8c\u70ef\u6216\u4eb2\u7535\u91d1\u4e2d\u95f4\u4f53\u4e0a\u8fdb\u884c\u5206\u5b50\u5185\u6c22\u8f6c\u79fb\u7684\u8f6c\u5316<sup>15-20<\/sup>(Scheme 6)\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/6-10.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33283 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/6-10.jpg\" alt=\"\" width=\"695\" height=\"400\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/6-10.jpg 695w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/6-10-300x173.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/6-10-680x391.jpg 680w\" sizes=\"(max-width: 695px) 100vw, 695px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 6 \u6c22\u8f6c\u79fb\u8fc7\u7a0b\u8f6c\u5316<\/p>\n<p><strong>2.2 <\/strong><strong>\u81ea\u7531\u57fa\u6c22\u8f6c\u79fb<\/strong><\/p>\n<p>Gagosz\u6559\u6388\u5229\u7528\u6c27\u5316\u8fd8\u539f\u6761\u4ef6\u4e0b\u7684\u81ea\u7531\u57fa\u5316\u5b66\uff0c\u6765\u53d1\u5c55\u6d89\u53ca\u4e2d\u95f4\u6c22\u8f6c\u79fb\u6b65\u9aa4\u7684\u8f6c\u5316\u548c\u5bf9\u5b9e\u73b0\u70ef\u70c3\u533a\u57df\u548c\u975e\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u5b98\u80fd\u56e2\u5316\u7684\u53cd\u5e94<sup>21-23<\/sup>(Scheme 7)\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/7-9.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33284 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/7-9.jpg\" alt=\"\" width=\"1256\" height=\"427\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/7-9.jpg 1256w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/7-9-300x102.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/7-9-680x231.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/7-9-768x261.jpg 768w\" sizes=\"(max-width: 1256px) 100vw, 1256px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 7\u81ea\u7531\u57fa\u6c22\u8f6c\u79fb<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] Revol, G., McCallum, T., Morin, M., Gagosz, F. &amp; Barriault, L.Photoredox Transformations with Dimeric Gold Complexes. <em>Angew. Chem. Int. Ed.<\/em> (2013) <strong>52<\/strong>, 13342-13345, doi:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.201306727\">10.1002\/anie.201306727<\/a>.<\/li>\n<li>[2] Henrion, G., Chavas, T. E. J., Le\u2005Goff, X. &amp; Gagosz, F.Biarylphosphonite Gold(I) Complexes as Superior Catalysts for Oxidative Cyclization of Propynyl Arenes into Indan-2-ones. <em>Angew. Chem. Int. Ed.<\/em> (2013) <strong>52<\/strong>, 6277-6282, doi:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/anie.201301015\">10.1002\/anie.201301015.<\/a><\/li>\n<li>[3] Escalle, A., Mora, G., Gagosz, F., M\u00e9zailles, N., Le Goff, X. F., Jean, Y. &amp; Le Floch, P.Cationic Dimetallic Gold Hydride Complex Stabilized by a Xantphos-Phosphole ligand: Synthesis, X-ray Crystal Structure, and Density Functional Theory Study. <em>Inorganic Chemistry<\/em> (2009) <strong>48<\/strong>, 8415-8422, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ic901014r\">10.1021\/ic901014r.<\/a><\/li>\n<li>[4] Zhao, Q., Le\u00f3n\u2005Rayo, D. F., Campeau, D., Daenen, M. &amp; Gagosz, F.Gold-Catalyzed Formal Dehydro-Diels\u2013Alder Reactions of Ene-Ynamide Derivatives Bearing Terminal Alkyne Chains: Scope and Mechanistic Studies. <em>Angew. Chem. Int. Ed.<\/em> (2018) <strong>57<\/strong>, 13603-13607, doi:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/anie.201807136\">10.1002\/anie.201807136.<\/a><\/li>\n<li>[5] Cao, Z. &amp; Gagosz, F.Gold-Catalyzed Tandem Cycloisomerization\/Cope Rearrangement: An Efficient Access to the Hydroazulenic Motif. <em>Angew. Chem. Int. Ed.<\/em> (2013) <strong>52<\/strong>, 9014-9018, doi:<a href=\"https:\/\/doi.org\/10.1002\/anie.201304497\">10.1002\/anie.201304497.<\/a><\/li>\n<li>[6] Bolte, B. &amp; Gagosz, F.Gold and Br\u00f8nsted Acid Catalyzed Hydride Shift onto Allenes: Divergence in Product Selectivity. <em>J. Am. Chem. Soc.<\/em> (2011) <strong>133<\/strong>, 7696-7699, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja202336p\">10.1021\/ja202336p<\/a>.<\/li>\n<li>[7] Buzas, A. K., Istrate, F. M. &amp; Gagosz, F.Gold(I)-Catalyzed 5-endo Hydroxy- and Alkoxycyclization of 1,5-Enynes: Efficient Access to Functionalized Cyclopentenes. <em>Angew. Chem. Int. Ed.<\/em> (2007) <strong>46<\/strong>, 1141-1144, doi:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/anie.200604140\">10.1002\/anie.200604140.<\/a><\/li>\n<li>[8] M\u00e9zailles, N., Ricard, L. &amp; Gagosz, F.Phosphine Gold(I) Bis-(trifluoromethanesulfonyl)imidate Complexes as New Highly Efficient and Air-Stable Catalysts for the Cycloisomerization of Enynes. <em>Org. Lett.<\/em> (2005) <strong>7<\/strong>, 4133-4136, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ol0515917\">10.1021\/ol0515917.<\/a><\/li>\n<li>[9] Lonca, G. H., Tejo, C., Chan, H. L., Chiba, S. &amp; Gagosz, F.Gold(i)-catalyzed 6-endo-dig azide\u2013yne cyclization: efficient access to 2H-1,3-oxazines. <em>Chem. Commun.<\/em> (2017) <strong>53<\/strong>, 736-739, doi:<a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2017\/CC\/C6CC08397H\">10.1039\/C6CC08397H.<\/a><\/li>\n<li>[10] Gronnier, C., Bel, P. F. d., Henrion, G., Kramer, S. &amp; Gagosz, F.Divergent Product Selectivity in Gold- versus Silver-Catalyzed Reaction of 2-Propynyloxy-6-fluoropyridines with Arylamines. <em>Org. Lett.<\/em> (2014) <strong>16<\/strong>, 2092-2095, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ol500939v\">10.1021\/ol500939v.<\/a><\/li>\n<li>[11] Prechter, A., Henrion, G., Faudot\u2005dit\u2005Bel, P. &amp; Gagosz, F.Gold-Catalyzed Synthesis of Functionalized Pyridines by Using 2H-Azirines as Synthetic Equivalents of Alkenyl Nitrenes. <em>Angew. Chem. Int. Ed.<\/em> (2014) <strong>53<\/strong>, 4959-4963, doi:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.201402470\">10.1002\/anie.201402470.<\/a><\/li>\n<li>[12] Gronnier, C., Boissonnat, G. &amp; Gagosz, F.Au-Catalyzed Formation of Functionalized Quinolines from 2-Alkynyl Arylazide Derivatives. <em>Org. Lett.<\/em> (2013) <strong>15<\/strong>, 4234-4237, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ol4019634\">10.1021\/ol4019634.<\/a><\/li>\n<li>[13] Wetzel, A. &amp; Gagosz, F.Gold-Catalyzed Transformation of 2-Alkynyl Arylazides: Efficient Access to the Valuable Pseudoindoxyl and Indolyl Frameworks. <em>Angew. Chem. Int. Ed.<\/em> (2011) <strong>50<\/strong>, 7354-7358, doi:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/anie.201102707\">10.1002\/anie.201102707.<\/a><\/li>\n<li>[14] Kramer, S., Odabachian, Y., Overgaard, J., Rottl\u00e4nder, M., Gagosz, F. &amp; Skrydstrup, T.Taking Advantage of the Ambivalent Reactivity of Ynamides in Gold Catalysis: A Rare Case of Alkyne Dimerization. <em>Angew. Chem. Int. Ed.<\/em> (2011) <strong>50<\/strong>, 5090-5094, doi:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.201100327\">10.1002\/anie.201100327.<\/a><\/li>\n<li>[15] Gandamana, D. A., Wang, B., Tejo, C., Bolte, B., Gagosz, F. &amp; Chiba, S.Alkyl Ethers as Traceless Hydride Donors in Br\u00f8nsted Acid Catalyzed Intramolecular Hydrogen Atom Transfer. <em>Angew. Chem. Int. Ed.<\/em> (2018) <strong>57<\/strong>, 6181-6185, doi:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/anie.201801953\">10.1002\/anie.201801953.<\/a><\/li>\n<li>[16] Wang, B., Gandamana, D. A., Gagosz, F. &amp; Chiba, S.Diastereoselective Intramolecular Hydride Transfer under Br\u00f8nsted Acid Catalysis. <em>Org. Lett.<\/em> (2019) <strong>21<\/strong>, 2298-2301, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.orglett.9b00590\">10.1021\/acs.orglett.9b00590.<\/a><\/li>\n<li>[17] Boreux, A., Lonca, G. H., Riant, O. &amp; Gagosz, F.Synthesis of Trifluoromethyl-allenes by Gold-Catalyzed Rearrangement of Propargyl Benzyl Ethers. <em>Org. Lett.<\/em> (2016) <strong>18<\/strong>, 5162-5165, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.orglett.6b02636\">10.1021\/acs.orglett.6b02636.<\/a><\/li>\n<li>[18] Bolte, B., Odabachian, Y. &amp; Gagosz, F.Gold(I)-Catalyzed Rearrangement of Propargyl Benzyl Ethers: A Practical Method for the Generation and in Situ Transformation of Substituted Allenes. <em>J. Am. Chem. Soc.<\/em> (2010) <strong>132<\/strong>, 7294-7296, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja1020469\">10.1021\/ja1020469.<\/a><\/li>\n<li>[19] Jurberg, I. D., Odabachian, Y. &amp; Gagosz, F.Hydroalkylation of Alkynyl Ethers via a Gold(I)-Catalyzed 1,5-Hydride Shift\/Cyclization Sequence. <em>J. Am. Chem. Soc.<\/em> (2010) <strong>132<\/strong>, 3543-3552, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja9100134\">10.1021\/ja9100134.<\/a><\/li>\n<li>[20] Buzas, A. &amp; Gagosz, F.Gold(I) Catalyzed Isomerization of 5-en-2-yn-1-yl Acetates:\u2009 An Efficient Access to Acetoxy Bicyclo[3.1.0]hexenes and 2-Cycloalken-1-ones. <em>J. Am. Chem. Soc.<\/em> (2006) <strong>128<\/strong>, 12614-12615, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja064223m\">10.1021\/ja064223m.<\/a><\/li>\n<li>[21] Boreux, A., Indukuri, K., Gagosz, F. &amp; Riant, O.Acyl Fluorides as Efficient Electrophiles for the Copper-Catalyzed Boroacylation of Allenes. <em>ACS. Catal.<\/em> (2017) <strong>7<\/strong>, 8200-8204, doi<a href=\"https:\/\/doi.org\/10.1021\/acscatal.7b02938\">:10.1021\/acscatal.7b02938.<\/a><\/li>\n<li>[22] Lonca, G. H., Ong, D. Y., Tran, T. M. H., Tejo, C., Chiba, S. &amp; Gagosz, F.Anti-Markovnikov Hydrofunctionalization of Alkenes: Use of a Benzyl Group as a Traceless Redox-Active Hydrogen Donor. <em>Angew. Chem. Int. Ed.<\/em> (2017) <strong>56<\/strong>, 11440-11444, doi:<a href=\"https:\/\/doi.org\/10.1002\/anie.201705368\">10.1002\/anie.201705368.<\/a><\/li>\n<li>[23] Gronnier, C., Kramer, S., Odabachian, Y. &amp; Gagosz, F.Cu(I)-Catalyzed Oxidative Cyclization of Alkynyl Oxiranes and Oxetanes. <em>J. Am. Chem. Soc.<\/em> (2012) <strong>134<\/strong>, 828-831, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja209866a\">10.1021\/ja209866a.<\/a><\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005 \u77f3\u6cb9\u919a \u6982\u8981 Fabien Gagosz, \u6e25\u592a\u534e\u5927\u5b66\u5316\u5b66\u4e0e\u751f\u7269\u5206\u5b50\u79d1\u5b66\u7cfb\u6559\u6388\uff0c\u6709\u673a\u5316\u5b66\u5bb6\u3002\u8bfe\u9898\u7ec4\u4e3b\u9875\uff1ahttps:\/\/www.thegagoszgroup.com\/ \u7ecf\u5386 1994-1997\u5e74 \u65af\u7279\u62c9\u65af\u5821\u5927\u5b66\u83b7\u5f97\u5b66\u58eb\u5b66\u4f4d 1997\u5e74 \u6cd5\u56fd\u8def\u6613\u65af-\u5df4\u65af\u5fb7\u5927\u5b66DEA\uff08Dr. C. Mioskowski\uff09 1998-2002\u5e74 \u5df4\u9ece\u7efc\u5408\u7406\u5de5\u5927\u5b66\u83b7\u5f97\u535a\u58eb\uff08Prof. S. Z. Zard\uff09 2003-2004\u5e74 \u4f26\u6566\u5927\u5b66\u535a\u58eb\u540e\uff08Prof. W. B. Motherwell\uff09 2004-2007\u5e74 \u5df4\u9ece\u7efc\u5408\u7406\u5de5\u5927\u5b66CNRS\u7814\u7a76\u5458\uff08CR2\uff09 2007-2012\u5e74 \u5df4\u9ece\u7efc\u5408\u7406\u5de5\u5927\u5b66CNRS\u7814\u7a76\u5458\uff08CR1\uff09 2012-2016\u5e74 \u5df4\u9ece\u7efc\u5408\u7406\u5de5\u5927\u5b66CNRS\u7814\u7a76\u5458\uff08DR2\uff09 2016-\u81f3\u4eca\u00a0 \u00a0\u6e25\u592a\u534e\u5927\u5b66\u6b63\u6559\u6388 \u83b7\u5956\u7ecf\u5386 2013 Junior Distinguished Member of the French Chemical Society 2012 ACROS award for young investigator from the French Chemical Society 2010 Thieme Chemistry Journal Award 2008 CNRS Bronze Medal Award 2003 Dina Surdin Ph.D. Thesis Award from the French Chemical Society 2002 &#8220;Roche Symposium for Leading Chemists of the Next Decade&#8221; Award \u7814\u7a76\u65b9\u5411 Fabien Gagosz\u6559\u6388\u7684\u7814\u7a76\u5174\u8da3\u96c6\u4e2d\u5728\u8bbe\u8ba1\u65b0\u7684\u50ac\u5316\u65b9\u6cd5\u5b66\uff0c\u5e76\u5c06\u5176\u7528\u4e8e\u5f00\u53d1\u5404\u79cd\u611f\u5174\u8da3\u7684\u5206\u5b50\u7ed3\u6784\u5408\u6210\u3002\u8bfe\u9898\u7ec4\u7814\u7a76\u8ba1\u5212\u4e13\u6ce8\u4e8e\u65b0\u50ac\u5316\u53cd\u5e94\u7684\u8bbe\u8ba1\u548c\u65b0\u5408\u6210\u65b9\u6cd5\u7684\u5f00\u53d1\uff0c\u7279\u522b\u5173\u6ce8\u548c\u504f\u7231\u540e\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u548c\u91d1\u7684\u5747\u76f8\u50ac\u5316\u3002 1. \u91d1\u50ac\u5316 \u91d1\u7684\u5747\u76f8\u50ac\u5316\u662f\u4e00\u79cd\u53ef\u6709\u6548\u5730\u4f7f\u78b3-\u03c0\u4f53\u7cfb\u5b98\u80fd\u56e2\u5316\u5e76\u4e3a\u5206\u5b50\u590d\u6742\u6027\u548c\u591a\u6837\u6027\u751f\u6210\u7684\u4e00\u79cd\u7279\u5b9a\u4e14\u529f\u80fd\u5f3a\u5927\u7684\u5408\u6210\u65b9\u6cd5\u3002\u4eb2\u7535\u7684\u91d1\u7edc\u5408\u7269\u5728\u5176\u4ed6\u5b98\u80fd\u56e2\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\u9009\u62e9\u6027\u4e0e\u7094\u70c3\u6216\u8054\u70ef\u7ed3\u5408\uff0c\u5e76\u901a\u8fc7\u591a\u79cd\u4eb2\u6838\u7269\u8d28\u6fc0\u6d3b\u5b83\u4eec\u5b9e\u73b0\u5b98\u80fd\u56e2\u5316\u7684\u80fd\u529b\uff0c\u4e3a\u53d1\u73b0\u65b0\u7684\u8f6c\u5316\u63d0\u4f9b\u4e86\u72ec\u6b8a\u7684\u673a\u4f1a\u3002\u9664\u4e86\u4f5c\u4e3aLewis\u9178\u4e4b\u5916\uff0c\u91d1\u8fd8\u53ef\u80fd\u4f5c\u4e3a\u7535\u5b50\u4f9b\u4f53\uff0c\u4ece\u800c\u4f7f\u4e2d\u95f4\u9633\u79bb\u5b50\u7269\u79cd\u7a33\u5b9a\u3002\u91d1\u914d\u5408\u7269\u8fd8\u5177\u6709\u65e0\u6bd2\u3001\u8010\u6c27\u548c\u4e0e\u6c34\u73af\u5883\u76f8\u5bb9\u7684\u7279\u6027\uff0c\u56e0\u6b64\u53ef\u4ee5\u5728\u73af\u5883\u53cb\u597d\u7684\u5de5\u4e1a\u8fc7\u7a0b\u548c\u5b9e\u9645\u64cd\u4f5c\u4e2d\u5177\u6709\u6f5c\u5728\u5e94\u7528\u3002Gagosz\u8bfe\u9898\u7ec4\u6b63\u5728\u5229\u7528\u4eb2\u7535\u91d1\u7edc\u5408\u7269\u7684\u72ec\u7279\u53cd\u5e94\u6027\u6765\u53d1\u73b0\u53ef\u80fd\u9002\u7528\u4e8e\u6709\u673a\u5408\u6210\u5404\u4e2a\u9886\u57df\u7684\u65b0\u9896\u6709\u673a\u5316\u5b66\u53cd\u5e94\uff08scheme 1\uff09\u3002 Scheme 1 \u91d1\u50ac\u5316 1.1 \u65b0\u578b\u91d1\u50ac\u5316\u5242 \u4e3a\u4e86\u63d0\u9ad8\u53cd\u5e94\u7684\u6548\u7387\u548c\u9009\u62e9\u6027\uff0c\u5f00\u53d1\u65b0\u53cd\u5e94\u6027\u5e76\u8c03\u8282\u5408\u6210\u8f6c\u5316\u4e2d\u91d1\u4e2d\u95f4\u4f53\u7684\u4f5c\u7528\uff0c\u65b0\u7684\u91d1\u50ac\u5316\u5242\u7684\u5408\u6210\u81f3\u5173\u91cd\u8981\u3002Gagosz\u5c0f\u7ec4\u5728\u8fd9\u4e00\u9886\u57df\u5f88\u6d3b\u8dc3\uff0c\u5df2\u7ecf\u5f00\u53d1\u4e86\u591a\u4e2a\u91d1(I)\u914d\u5408\u7269\u5bb6\u65cf\uff08scheme 2\uff09\uff0c\u5e76\u4e14\u5df2\u88ab\u8be5\u9886\u57df\u7684\u7814\u7a76\u5c0f\u7ec4\u5e7f\u6cdb\u4f7f\u75281-3\u3002 Scheme 2 \u65b0\u578b\u91d1\u50ac\u5316\u5242 1.2 \u73af\u5316&#8211;\u591a\u91cd\u952e\u5f62\u6210\u8f6c\u5316 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