{"id":33299,"date":"2020-07-13T08:05:42","date_gmt":"2020-07-13T00:05:42","guid":{"rendered":"\/\/www.gsbet888.com\/?p=33299"},"modified":"2020-07-09T10:36:13","modified_gmt":"2020-07-09T02:36:13","slug":"tim-j-donohoe","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/2020\/07\/tim-j-donohoe.html","title":{"rendered":"Tim J. Donohoe"},"content":{"rendered":"

\u672c\u6587\u4f5c\u8005 \u77f3\u6cb9\u919a<\/p>\n

\u6982\u8981<\/strong><\/h4>\n
Tim J. Donohoe\uff0c\u82f1\u56fd\u725b\u6d25\u5927\u5b66\u5316\u5b66\u7cfb\u6559\u6388\u548c\u725b\u6d25\u5927\u5b66\u83ab\u5fb7\u6797\u5b66\u9662\u7814\u7a76\u5458\uff0c\u6709\u673a\u5316\u5b66\u5bb6\uff0c\u8bfe\u9898\u7ec4\u4e3b\u9875\uff1ahttp:\/\/donohoe.chem.ox.ac.uk\/<\/a><\/p>\n
\u7ecf\u5386<\/strong><\/h4>\n\n
1985-1989\u5e74 \u5df4\u65af\u5927\u5b66\u83b7\u5f97\u5b66\u58eb\u5b66\u4f4d\uff08Professor T. J. Gallagher\uff09<\/li>\n
1989-1992\u5e74 \u725b\u6d25\u5927\u5b66\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\uff08Prof. S. G. Davies\uff09<\/li>\n
1993-1994\u5e74 \u535a\u58eb\u540e\u7814\u7a76\uff08Prof. P. D. Magnus FRS\uff09<\/li>\n
1994-2000\u5e74 \u66fc\u5f7b\u65af\u7279\u5927\u5b66\u5316\u5b66\u7cfb\u8bb2\u5e08<\/li>\n
2000-2001\u5e74 \u66fc\u5f7b\u65af\u7279\u5927\u5b66\u5316\u5b66\u7cfb\u8bfb\u8005<\/li>\n
2001-2004\u5e74 \u725b\u6d25\u5927\u5b66\u5316\u5b66\u8bb2\u5e08\u548c\u83ab\u5fb7\u6797\u5b66\u9662\u7814\u7a76\u5458<\/li>\n
2004-\u81f3\u4eca\u00a0 \u00a0\u725b\u6d25\u5927\u5b66\u5316\u5b66\u7cfb\u6559\u6388\u548c\u83ab\u5fb7\u6797\u5b66\u9662\u7814\u7a76\u5458<\/li>\n
2006-2011\u5e74 \u725b\u6d25\u5927\u5b66\u6709\u673a\u5316\u5b66\u7cfb\u4e3b\u4efb<\/li>\n<\/ul>\n
\u83b7\u5956\u7ecf\u5386<\/strong><\/h4>\n\n
2015 Editor of Tetrahedron Letters<\/li>\n
2014 EPSRC Established Career Fellow<\/li>\n
2014 Royal Society of Chemistry: Charles Rees Award<\/li>\n
2012 AstraZeneca, GlaxoSmithKline, Pfizer & Syngenta Prize for Process Chemistry Research<\/li>\n
2011 Royal Society of Chemistry: Synthetic Organic Chemistry Award<\/li>\n
2006 Royal Society of Chemistry: Corday-Morgan Medal<\/li>\n
2002 AstraZeneca Award for Organic Chemistry<\/li>\n
2001 Novartis Young Investigator Award<\/li>\n
2000 Pfizer Academic Award<\/li>\n
1998 Glaxo Wellcome award for Innovative Chemistry<\/li>\n
1998 \u2013 2001 Associate Editor (UK) for the journal Tetrahedron Letters<\/li>\n<\/ul>\n
\u7814\u7a76\u65b9\u5411<\/strong><\/h4>\n
Donohoe\u5c0f\u7ec4\u7684\u7814\u7a76\u5174\u8da3\u5728\u4e8e\u6709\u673a\u5316\u5b66\u5bf9\u533b\u5b66\u548c\u5929\u7136\u4ea7\u7269\u9886\u57df\u7684\u8d21\u732e\uff0c\u4ee5\u53ca\u5f00\u53d1\u7528\u4e8e\u6709\u673a\u5408\u6210\u548c\u4e0d\u5bf9\u79f0\u5408\u6210\u7684\u65b0\u65b9\u6cd5\uff0c\u5229\u7528\u53d1\u5c55\u7684\u5316\u5b66\u65b9\u6cd5\u6765\u5236\u9020\u5177\u6709\u7279\u6b8a\u751f\u7269\u6d3b\u6027\u7684\u5929\u7136\u4ea7\u7269\u3002<\/p>\n
\u76ee\u524d\u5728\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\uff0c\u8f6c\u79fb\u6c22\u5316\uff0c\u6c27\u5316\uff0c\u90e8\u5206\u8fd8\u539f\uff0c\u94af\u50ac\u5316\u7684\u82b3\u57fa\u5316\u7b49\u591a\u4e2a\u65b9\u9762\u505a\u51fa\u7a81\u51fa\u7684\u7814\u7a76\u3002<\/p>\n
$\"\"$ <\/a><\/p>\n
1. \u5929\u7136\u4ea7\u7269\u5168\u5408\u6210<\/strong>^{1-3<\/sup><\/strong><\/span><\/p>\n}
Donohoe\u5c0f\u7ec4\u7684\u7814\u7a76\u5174\u8da3\u5728\u4e8e\u6709\u673a\u5316\u5b66\u5bf9\u533b\u5b66\u548c\u5929\u7136\u4ea7\u7269\u9886\u57df\u7684\u8d21\u732e\u5e76\u5f00\u53d1\u65b0\u65b9\u6cd5\u6765\u5bf9\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u5206\u5b50\u7684\u5168\u5408\u6210(Fig.1)\u3002Donohoe\u5c0f\u7ec4\u5728\u6709\u673a\u5206\u5b50\u9009\u62e9\u6027\u5b98\u80fd\u5316\u65b9\u9762\u7684\u53d1\u5c55\u4e86\u8bb8\u591a\u65b0\u53cd\u5e94\uff0c\u5e76\u5e94\u7528\u4e8e\u5168\u5408\u6210\u9886\u57df\uff0c\u9ad8\u6548\u7684\u5b8c\u6210\u4e86\u590d\u6742\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210\u3002\u5176\u4e2d\u5305\u62ec\uff1apericosine B, sylvaticin, cis-sylvaticin, hygromycin, dehydromicrosclerodermin B, secosyrin 1, australite, cyclindricine B, lactacystin-\u03b2-lactone, deoxypukolide, muscopyridine, streptonigrin and the berberine alkaloids.\uff08Fig.2\uff09<\/p>\n
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Figure 1 \u76ee\u524d\u7684\u5408\u6210\u76ee\u6807<\/p>\n
$\"\"$ <\/a><\/p>\n
Figure 2 \u5df2\u5b8c\u6210\u7684\u5408\u6210\u76ee\u6807<\/p>\n
2. \u8f6c\u79fb\u6c22\u5316<\/strong><\/span><\/p>\n
\u76ee\u524d\uff0cDonohoe\u5c0f\u7ec4\u5728\u8f6c\u79fb\u6c22\u5316\u9886\u57df\u53d8\u5f97\u6d3b\u8dc3\u8d77\u6765\u3002\u8f6c\u79fb\u6c22\u5316\u662f\u5f62\u6210C-C\u548cC-N\u952e\u7684\u5f3a\u5927\u50ac\u5316\u65b9\u6cd5\uff0c\u5e76\u4e14\u53ea\u80fd\u5c06\u6c34\u4f5c\u4e3a\u526f\u4ea7\u7269\u3002\u6700\u521d\u7684\u5de5\u4f5c\u96c6\u4e2d\u4e8e\u7532\u9187\u5728\u70ef\u9187\u5316\u70f7\u57fa\u5316\u4e2d\u7684\u4f5c\u7528\uff0c\u800c\u6700\u8fd1\u7684\u7814\u7a76\u5df2\u7ecf\u5f00\u53d1\u4e86\u4e94\u7532\u57fa\u82ef\uff08Ph *\uff09\u57fa\u56e2\uff0c\u5b83\u662f\u501f\u6c22\u4f4d\u70f7\u57fa\u5316\u53cd\u5e94\u4e2d\u5f3a\u5927\u591a\u7528\u9014\u53d6\u4ee3\u57fa\u3002Donohoe\u5c0f\u7ec4\u5e94\u7528\u8f6c\u79fb\u6c22\u5316\u7684\u65b9\u6cd5\uff0c\u6784\u5efa\u4e86\u4e00\u7cfb\u5217\u5177\u6709\u624b\u6027\u7684\u5316\u5408\u7269^{4-11<\/sup>\u3002<\/p>\n}
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Figure 3 \u8f6c\u79fb\u6c22\u5316<\/p>\n
3. \u6c27\u5316\u53cd\u5e94<\/strong><\/span><\/p>\n
Donohoe\u5c0f\u7ec4\u53e6\u5916\u4e00\u4e2a\u7814\u7a76\u4e3b\u9898\u662f\u7528\u50ac\u5316\u8bd5\u5242\u63a7\u5236\u70ef\u70c3\u7684\u6c27\u5316\u3002Donohoe\u6559\u6388\u5bf9\u70ef\u4e19\u57fa\u6c28\u57fa\u7532\u9178\u916f\u7684\u675f\u7f1a\u6c28\u57fa\u7f9f\u57fa\u5316\u7684\u7814\u7a76\u4ee5\u53ca\u5bf9\u673a\u7406\u7684\u505a\u4e86\u8be6\u7ec6\u7684\u89e3\u91ca\uff0c\u5e76\u5c06\u65b0\u7684\u4e00\u7ec4\u57fa\u4e8eN-O\u7684\u518d\u6c27\u5316\u5242\u5f15\u5165\u5230\u50ac\u5316\u6c28\u57fa\u7f9f\u57fa\u5316\u53cd\u5e94\u4e2d\u5f97\u5230\u4e86\u4e00\u79cd\u529f\u80fd\u66f4\u5f3a\u5927\uff0c\u4ea7\u7387\u66f4\u9ad8\u7684\u6c28\u57fa\u7f9f\u57fa\u5316\u65b9\u6cd5\u3002 Donohoe\u6559\u6388\u5c06\u8fd9\u79cd\u65b9\u6cd5\u4ee5\u7279\u522b\u6709\u6548\u7684\u65b9\u5f0f\u5236\u5907\u6c28\u57fa\u73af\u9187(-)-\u6f6e\u9709\u7d20\u7684\u5408\u6210\u3002\u6700\u7ec8\u901a\u8fc7\u4f7f\u7528Mitsunobu\u7cd6\u57fa\u5316\u53cd\u5e94\u4ee5\u4ec517\u4e2a\u7ebf\u6027\u6b65\u9aa4\uff08\u548c10\uff05\u7684\u603b\u6536\u7387\uff09\u5b8c\u6210\u4e86\u5929\u7136\u4ea7\u7269\u7684\u5408\u6210\uff0c\u4ece\u800c\u5f62\u6210\u4e86\u5177\u6709\u826f\u597d\u7acb\u4f53\u9009\u62e9\u6027\u7684\u56f0\u96be\u7684\u7cd6\u82f7\u952e\u3002<\/p>\n
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Figure 4 \u6c27\u5316\u53cd\u5e94<\/p>\n
\u5bf9\u50ac\u5316\u7531\u4e8c\u9187\u548c\u6c28\u57fa\u9187\u5f62\u6210\u56db\u6c22\u544b\u5583\u73af\u548c\u5421\u54af\u70f7\u73af\u7ed3\u6784\u7684\u7814\u7a76\u8868\u660e\uff0c\u5229\u7528Os(IV)-(VI)\u5bf9\u53ef\u4ee5\u907f\u514dOs\uff08VIII\uff09\u7684\u5b58\u5728\u3002\u5e76\u53d1\u73b0\u4e86OMs\u7f6e\u6362\/\u6c22\u5316\u7269\u8f6c\u79fb\u5e8f\u5217\uff0c\u7136\u540e\u5728\u5206\u5b50\u5185\u6355\u83b7\u6c27\u79bb\u5b50\u4ee5\u5f62\u6210\u53cd\u5f0fTHF\uff08\u7531\u6c18\u6807\u8bb0\u652f\u6301\uff09\u3002\u5728\u5929\u7136\u4ea7\u7269(+)-\u987a\u5f0f-sylvaticin\u548c(+)-sylvaticin\u7684\u5408\u6210\u4e2d\u4f7f\u7528\u4e86\u53cc\u6c27\u5316\u73af\u5316\u548c\u6c22\u5316\u7269\u8f6c\u79fb\u7684\u7ec4\u5408\u53cd\u5e94^{12-16<\/sup>\u3002<\/p>\n}
$\"\"$ <\/a><\/strong><\/p>\n
Figure 4 \u6c27\u5316\u53cd\u5e94<\/p>\n
4. \u9009\u62e9\u6027\u8fd8\u539f<\/strong>^{17-18<\/sup><\/strong><\/span><\/p>\n}
Donohoe\u6559\u6388\u4e00\u76f4\u5728\u5f00\u53d1\u4f7f\u7528\u5355\u7535\u5b50\u8fd8\u539f\u5242\uff08\u5982\uff08\u50ac\u5316\uff09LiDBB\uff09\u90e8\u5206\u8fd8\u539f\u82b3\u9999\u65cf\u6742\u73af\u7684\u5174\u8da3\u3002\u76ee\u524d\u7684\u5de5\u4f5c\u5df2\u7ecf\u80fd\u591f\u4ee5\u9009\u62e9\u6027\u548c\u9ad8\u6536\u7387\u7684\u65b9\u5f0f\u8fd8\u539f\u5421\u54af\uff0c\u5421\u5576\u548c\u544b\u5583\uff0c\u901a\u8fc7\u8fd9\u79cd\u5316\u5b66\u65b9\u6cd5\u5236\u5907\u7684\u6742\u73af\u5bf9\u4e8e\u5929\u7136\uff08\u548c\u836f\u7528\uff09\u4ea7\u54c1\u5408\u6210\u5177\u6709\u5f88\u5927\u7684\u6f5c\u529b\u3002\u8bfe\u9898\u7ec4\u90e8\u5206\u8fd8\u539f\u7684\u65b9\u6cd5\u5df2\u7ecf\u5728\u590d\u6742\u5206\u5b50\u7684\u5408\u6210\u4e2d\u5f97\u5230\u4e86\u5e94\u7528\u3002\u5982\u5305\u62ec1-epiaustraline, hyacinthcine A1, omuralide and KSM-2690 B. Current targets include cylindricine A and hyacinthacine\u5bb6\u65cf\u7b49\u3002<\/p>\n
. $\"\"$ <\/a><\/p>\n
Figure 5 \u90e8\u5206\u8fd8\u539f<\/p>\n
\u5176\u4ed6<\/h4>\n
1. Chem-station\u5bf9\u5176\u9898\u4e3a\u201c [5 + 1]\u73af\u5316\u50ac\u5316\u5408\u6210\u6709\u53d6\u4ee3\u7684\u73af\u5df1\u70f7<\/a>\u201d\u7684\u5de5\u4f5c\u505a\u4e86\u4ecb\u7ecd\u3002<\/p>\n
$\"\"$ <\/a><\/p>\n
2. Angew \u5bf9 Tim J. Donohoe<\/a>\u8fdb\u884c\u4e86\u4e13\u9898\u4ecb\u7ecd\u3002<\/p>\n
\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n\n
[1] Donohoe, T. J., Jones, C. R. & Barbosa, L. C. A.Total Synthesis of (\u00b1)-Streptonigrin: De Novo Construction of a Pentasubstituted Pyridine using Ring-Closing Metathesis. J. Am. Chem. Soc.<\/em> (2011) 133<\/strong>, 16418-16421, doi:10.1021\/ja207835w.<\/a><\/li>\n
[2] Gatland, A. E., Pilgrim, B. S., Procopiou, P. A. & Donohoe, T. J.Short and Efficient Syntheses of Protoberberine Alkaloids using Palladium-Catalyzed Enolate Arylation. Angew. Chem. Int. Ed.<\/em> (2014) 53<\/strong>, 14555-14558, doi:10.1002\/anie.201409164.<\/a><\/li>\n
[3] Donohoe, T. J., Jones, C. R., Kornahrens, A. F., Barbosa, L. C. A., Walport, L. J., Tatton, M. R., Baker, D. B.Total Synthesis of the Antitumor Antibiotic (\u00b1)-Streptonigrin: First- and Second-Generation Routes for de Novo Pyridine Formation Using Ring-Closing Metathesis. J. Org. Chem.<\/em> (2013) 78<\/strong>, 12338-12350, doi:10.1021\/jo402388f.<\/a><\/li>\n
[4] Armstrong, R. J., Akhtar, W. M., Young, T. A., Duarte, F. & Donohoe, T. J.Catalytic Asymmetric Synthesis of Cyclohexanes by Hydrogen Borrowing Annulations. Angew. Chem. Int. Ed.<\/em> (2019) 58<\/strong>, 12558-12562, doi:10.1002\/anie.201907514.<\/a><\/li>\n
[5] Smith, L. B., Armstrong, R. J., Matheau-Raven, D. & Donohoe, T. J.Chemo- and Regioselective Synthesis of Acyl-Cyclohexenes by a Tandem Acceptorless Dehydrogenation-[1,5]-Hydride Shift Cascade. J. Am. Chem. Soc.<\/em> (2020) 142<\/strong>, 2514-2523, doi:10.1021\/jacs.9b12296<\/a>.<\/li>\n
[6] Grozavu, A., Hepburn, H. B., Smith, P. J., Potukuchi, H. K., Lindsay-Scott, P. J. & Donohoe, T. J.The reductive C3 functionalization of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation. Nat. Chem.<\/em> (2019) 11<\/strong>, 242-247, doi:10.1038\/s41557-018-0178-5.<\/a><\/li>\n
[7] Akhtar, W. M., Armstrong, R. J., Frost, J. R., Stevenson, N. G. & Donohoe, T. J.Stereoselective Synthesis of Cyclohexanes via an Iridium Catalyzed (5 + 1) Annulation Strategy. J. Am. Chem. Soc.<\/em> (2018) 140<\/strong>, 11916-11920, doi:10.1021\/jacs.8b07776.<\/a><\/li>\n
[8] Akhtar, W. M., Cheong, C. B., Frost, J. R., Christensen, K. E., Stevenson, N. G. & Donohoe, T. J.Hydrogen Borrowing Catalysis with Secondary Alcohols: A New Route for the Generation of \u03b2-Branched Carbonyl Compounds. J. Am. Chem. Soc.<\/em> (2017) 139<\/strong>, 2577-2580, doi:10.1021\/jacs.6b12840.<\/a><\/li>\n
[9] Frost, J. R., Cheong, C. B., Akhtar, W. M., Caputo, D. F. J., Stevenson, N. G. & Donohoe, T. J.Strategic Application and Transformation of ortho-Disubstituted Phenyl and Cyclopropyl Ketones To Expand the Scope of Hydrogen Borrowing Catalysis. J. Am. Chem. Soc.<\/em> (2015) 137<\/strong>, 15664-15667, doi:10.1021\/jacs.5b11196.<\/a><\/li>\n
[10] Shen, D., Poole, D. L., Shotton, C. C., Kornahrens, A. F., Healy, M. P. & Donohoe, T. J.Hydrogen-Borrowing and Interrupted-Hydrogen-Borrowing Reactions of Ketones and Methanol Catalyzed by Iridium. Angew. Chem. Int. Ed.<\/em> (2015) 54<\/strong>, 1642-1645, doi:10.1002\/anie.201410391.<\/a><\/li>\n
[11] Chan, L. K. M., Poole, D. L., Shen, D., Healy, M. P. & Donohoe, T. J.Rhodium-Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of \u03b1-Branched Products. Angew. Chem. Int. Ed.<\/em> (2014) 53<\/strong>, 761-765, doi:10.1002\/anie.201307950.<\/a><\/li>\n
[12] Roushanbakhti, A., Liu, Y., Winship, P. C. M., Tucker, M. J., Akhtar, W. M., Walter, D. S., Donohoe, T. J.Cobalt versus Osmium: Control of Both trans and cis Selectivity in Construction of the EFG Rings of Pectenotoxin\u20054. Angew. Chem. Int. Ed.<\/em> (2017) 56<\/strong>, 14883-14887, doi:10.1002\/anie.201708278.<\/a><\/li>\n
[13] Donohoe, T. J. & Lipi\u0144ski, R. M.Interplay of Cascade Oxidative Cyclization and Hydride Shifts in the Synthesis of the ABC Spiroketal Ring System of Pectenotoxin-4. Angew. Chem. Int. Ed.<\/em> (2013) 52<\/strong>, 2491-2494, doi:10.1002\/anie.201208919.<\/a><\/li>\n
[14] Donohoe, T. J. & Pullin, R. D. C.Natural product synthesis as a challenging test of newly developed methodology. Chem. Commun.<\/em> (2012) 48<\/strong>, 11924-11938, doi:10.1039\/C2CC36040C.<\/a><\/li>\n
[15] Donohoe, T. J., Harris, R. M., Williams, O., Hargaden, G. C., Burrows, J. & Parker, J.Concise Syntheses of the Natural Products (+)-Sylvaticin and (+)-cis-Sylvaticin. J. Am. Chem. Soc.<\/em> (2009) 131<\/strong>, 12854-12861, doi:10.1021\/ja9049959.<\/a><\/li>\n
[16] Donohoe, T. J., Harris, R. M., Burrows, J. & Parker, J.Total Synthesis of (+)-cis-Sylvaticin:\u2009 Double Oxidative Cyclization Reactions Catalyzed by Osmium. J. Am. Chem. Soc.<\/em> (2006) 128<\/strong>, 13704-13705, doi:10.1021\/ja0660148.<\/a><\/li>\n
[17] Pilgrim, B. S. & Donohoe, T. J.Osmium-Catalyzed Oxidative Cyclization of Dienes and Their Derivatives. J. Org. Chem.<\/em> (2013) 78<\/strong>, 2149-2167, doi:10.1021\/jo302719y.<\/a><\/li>\n
[18] Donohoe, T. J., O\u2019Riordan, T. J. C., Peifer, M., Jones, C. R. & Miles, T. J.Asymmetric Synthesis of the Fully Elaborated Pyrrolidinone Core of Oxazolomycin A. Org. Lett.<\/em> (2012) 14<\/strong>, 5460-5463, doi:10.1021\/ol302541j.<\/a><\/li>\n<\/ul>\n
\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005 \u77f3\u6cb9\u919a \u6982\u8981 Tim J. Donohoe\uff0c\u82f1\u56fd\u725b\u6d25\u5927\u5b66\u5316\u5b66\u7cfb\u6559\u6388\u548c\u725b\u6d25\u5927\u5b66\u83ab\u5fb7\u6797\u5b66\u9662\u7814\u7a76\u5458\uff0c\u6709\u673a\u5316\u5b66\u5bb6\uff0c\u8bfe\u9898\u7ec4\u4e3b\u9875\uff1ahttp:\/\/donohoe.chem.ox.ac.uk\/ \u7ecf\u5386 1985-1989\u5e74 \u5df4\u65af\u5927\u5b66\u83b7\u5f97\u5b66\u58eb\u5b66\u4f4d\uff08Professor T. J. Gallagher\uff09 1989-1992\u5e74 \u725b\u6d25\u5927\u5b66\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\uff08Prof. S. G. Davies\uff09 1993-1994\u5e74 \u535a\u58eb\u540e\u7814\u7a76\uff08Prof. P. D. Magnus FRS\uff09 1994-2000\u5e74 \u66fc\u5f7b\u65af\u7279\u5927\u5b66\u5316\u5b66\u7cfb\u8bb2\u5e08 2000-2001\u5e74 \u66fc\u5f7b\u65af\u7279\u5927\u5b66\u5316\u5b66\u7cfb\u8bfb\u8005 2001-2004\u5e74 \u725b\u6d25\u5927\u5b66\u5316\u5b66\u8bb2\u5e08\u548c\u83ab\u5fb7\u6797\u5b66\u9662\u7814\u7a76\u5458 2004-\u81f3\u4eca\u00a0 \u00a0\u725b\u6d25\u5927\u5b66\u5316\u5b66\u7cfb\u6559\u6388\u548c\u83ab\u5fb7\u6797\u5b66\u9662\u7814\u7a76\u5458 2006-2011\u5e74 \u725b\u6d25\u5927\u5b66\u6709\u673a\u5316\u5b66\u7cfb\u4e3b\u4efb \u83b7\u5956\u7ecf\u5386 2015 Editor of Tetrahedron Letters 2014 EPSRC Established Career Fellow 2014 Royal Society of Chemistry: Charles Rees Award 2012 AstraZeneca, GlaxoSmithKline, Pfizer & Syngenta Prize for Process Chemistry Research 2011 Royal Society of Chemistry: Synthetic Organic Chemistry Award 2006 Royal Society of Chemistry: Corday-Morgan Medal 2002 AstraZeneca Award for Organic Chemistry 2001 Novartis Young Investigator Award 2000 Pfizer Academic Award 1998 Glaxo Wellcome award for Innovative Chemistry 1998 \u2013 2001 Associate Editor (UK) for the journal […]","protected":false},"author":26,"featured_media":33308,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[212],"tags":[275,2851,128],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/F-20.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-8F5","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/33299"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=33299"}],"version-history":[{"count":1,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/33299\/revisions"}],"predecessor-version":[{"id":33309,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/33299\/revisions\/33309"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/33308"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=33299"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=33299"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=33299"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}