{"id":33457,"date":"2020-07-12T08:00:12","date_gmt":"2020-07-12T00:00:12","guid":{"rendered":"\/\/www.gsbet888.com\/?p=33457"},"modified":"2020-07-09T10:34:54","modified_gmt":"2020-07-09T02:34:54","slug":"%e6%89%8b%e6%80%a7%e7%a3%b7%e9%85%b8%e5%82%ac%e5%8c%96%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0%e5%8e%bb%e5%af%b9%e7%a7%b0%e5%8c%96%e5%8f%8d%e5%ba%94%e5%90%88%e6%88%90%e6%89%8b%e6%80%a7%e6%89%98%e7%83%b7","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2020\/07\/%e6%89%8b%e6%80%a7%e7%a3%b7%e9%85%b8%e5%82%ac%e5%8c%96%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0%e5%8e%bb%e5%af%b9%e7%a7%b0%e5%8c%96%e5%8f%8d%e5%ba%94%e5%90%88%e6%88%90%e6%89%8b%e6%80%a7%e6%89%98%e7%83%b7.html","title":{"rendered":"\u624b\u6027\u78f7\u9178\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u53bb\u5bf9\u79f0\u5316\u53cd\u5e94\u5408\u6210\u624b\u6027\u6258\u70f7\u7c7b\u5316\u5408\u7269"},"content":{"rendered":"<h4><strong>\u80cc\u666f\u4ecb\u7ecd<\/strong><\/h4>\n<p>tropane\u662f\u4e00\u7c7b\u5177\u6709\u591a\u6837\u751f\u7269\u6d3b\u6027\u7684\u5929\u7136\u4ea7\u7269\uff0c\u5176\u4e2d\u5927\u591a\u6570\u751f\u7269\u78b1\u90fd\u80fd\u591f\u4e0e\u7ec6\u80de\u7684\u795e\u7ecf\u9012\u8d28\u4e59\u9170\u80c6\u78b1\u76f8\u4e92\u4f5c\u7528\u3002\u81eaRobinson\u9898\u7ec4\u9996\u6b21\u5408\u6210\u6258\u70f7\u7c7b\u751f\u7269\u78b1\u8d77\uff0ctropan\u7684\u4e0d\u5bf9\u79f0\u5408\u6210\u53d6\u5f97\u4e86\u6781\u597d\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u7136\u800c\uff0c\u591a\u6570\u5408\u6210\u65b9\u6cd5\u5c40\u9650\u4e8e\u4e3b\u8981\u5c40\u9650\u4e8e\u624b\u6027\u6258\u70f7\u7c7b\u5316\u5408\u7269\u7684\u533a\u57df\u9009\u62e9\u6027\u53cd\u5e94\u548c\u975e\u624b\u6027\u6258\u70f7\u7c7b\u5316\u5408\u7269\u7684\u53bb\u5bf9\u79f0\u5316\u53cd\u5e94\u3002\u53ea\u6709\u5c11\u6570\u4e0d\u5bf9\u79f0\u5408\u62108-\u6c2e\u6742\u53cc\u73af[3.2.1]\u8f9b\u70f7\u7c7b\u5316\u5408\u7269\u7684\u62a5\u9053\u662f\u5173\u4e8e\u624b\u6027Rh(II)\u50ac\u5316\u4e0b\u5421\u54af\u548c\u70ef\u9187\u91cd\u6c2e\u4e59\u9178\u916f\u7684\u4e0d\u5bf9\u79f0[4+3]\u73af\u52a0\u6210\u53cd\u5e94<sup>[1]<\/sup>\u3001\u5f02\u55b9\u5549\u884d\u751f\u7684\u5076\u6c2e\u7532\u4e9a\u80fa\u4e0d\u5bf9\u79f01,3-\u5076\u6781\u73af\u52a0\u6210\u53cd\u5e94<sup>[2]<\/sup>\u4ee5\u53caL-\u812f\u6c28\u9178\u50ac\u5316\u5185\u6d88\u65cb-N-\u53d4\u4e01\u6c27\u7fb0\u57fa-(\u5421\u54af\u70f7-2,5-\u4e8c\u57fa)\u4e8c\u4e59\u919b\u7684\u4e0d\u5bf9\u79f0\u5206\u5b50\u5185\u7f9f\u919b\u53cd\u5e94<sup>[3]<\/sup>\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7814\u7a76\u80cc\u666f\u7684\u57fa\u7840\u4e0a\uff0c\u897f\u73ed\u7259Basque\u5927\u5b66Uria\u3001Vicario\u56e2\u961f\u548c\u897f\u73ed\u7259Basque\u5927\u5b66Merino\u56e2\u961f\u5171\u540c\u62a5\u9053\u4e86Br\u00f8nsted\u9178\u50ac\u5316\u5185\u6d88\u65cb\u73af\u70ef\u80fa\u884d\u751f\u7684\u73af\u6c27\u5316\u7269\u7684\u4e0d\u5bf9\u79f0\u5206\u5b50\u5185\u5f00\u73af\u53cd\u5e94\uff0c\u80fd\u591f\u4ee5\u826f\u597d\u81f3\u4f18\u79c0\u7684\u6536\u7387\u3001\u5bf9\u6620\u9009\u62e9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u975e\u5bf9\u6620\u9009\u62e9\u6027\u83b7\u5f97\u4e00\u7cfb\u5217\u624b\u60278-\u6c2e\u6742\u53cc\u73af[3.2.1]\u8f9b\u70f7\u7c7b\u5316\u5408\u7269\uff08Scheme 1\uff09\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e<\/p>\n<blockquote><p>\u201cEnantioselective Synthesis of Tropanes: Br\u00f8nsted Acid-Catalyzed Pseudotransannular Desymmetrization\u201d<\/p>\n<p>S. Rodriguez, U. Uria,* E. Reyes, L. Carrillo, T. Tejero, P. Merino*, J. L. Vicario* <em>Angew. <\/em><em>Chem. Int. Ed. <\/em><strong>2020<\/strong>, <em>59<\/em>, 6780. DOI: <a href=\"http:\/\/dx.doi.org\/10.1002\/anie.202000650\">10.1002\/anie.202000650<\/a><\/p><\/blockquote>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-40.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33458 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-40.jpg\" alt=\"\" width=\"532\" height=\"496\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-40.jpg 532w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-40-300x280.jpg 300w\" sizes=\"(max-width: 532px) 100vw, 532px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 1 \u80cc\u666f\u7814\u7a76<\/p>\n<h4><strong>\u8bba\u6587\u6982\u8981<\/strong><\/h4>\n<p>\u4ee5\u73af\u6c27\u73af\u5e9a\u80fa<strong>1a<\/strong>\u4e3a\u6a21\u677f\u5e95\u7269\uff0c\u4f5c\u8005\u73af\u6c27\u73af\u5e9a\u80fa\u4e2d\u6c28\u57fa\u4fdd\u62a4\u57fa\u3001\u50ac\u5316\u5242\u4ee5\u53ca\u6eb6\u5242\u7b49\u53cd\u5e94\u6761\u4ef6\u8fdb\u884c\u53cd\u590d\u7b5b\u9009\uff0c\u786e\u5b9a\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\uff08Table 1\uff09\uff1a<strong>1a<\/strong>\u4e3a\u5e95\u7269\uff0c5 mol% <strong>3g<\/strong>\u4e3a\u50ac\u5316\u5242\uff0c\u7532\u82ef\u4e3a\u6eb6\u5242\uff0c\u5728-20\u2103\u6761\u4ef6\u4e0b\u53cd\u5e9412\u5c0f\u65f6\uff0c\u80fd\u591f\u4ee595%\u7684\u6536\u7387\u548c94%\u7684\u5bf9\u6620\u9009\u62e9\u6027\u83b7\u5f97\u4ea7\u7269<strong>2a<\/strong>\u3002\u82e5\u5c06\u66f4\u6362\u6c2f\u82ef\u4f5c\u4e3a\u6eb6\u5242\uff0c\u540c\u6837\u80fd\u591f\u4ee593%\u7684\u6536\u7387\u548c92%\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u4ea7\u7269<strong>2a<\/strong>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-31.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33459 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-31.jpg\" alt=\"\" width=\"431\" height=\"824\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-31.jpg 431w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-31-157x300.jpg 157w\" sizes=\"(max-width: 431px) 100vw, 431px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Table 1 \u6761\u4ef6\u7b5b\u9009<\/p>\n<p>\u5728\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u4e86\u8003\u5bdf\uff08Table 2\uff09\u3002\u7814\u7a76\u53d1\u73b0\u4ee5\u7532\u82ef\u6216\u6c2f\u82ef\u4f5c\u4e3a\u6eb6\u5242\uff0c1\u4f4d\u70f7\u57fa\u53d6\u4ee3\u6216\u82b3\u57fa\u53d6\u4ee3\u7684\u5185\u6d88\u65cb4,5-\u73af\u6c27\u73af\u5e9a\u80fa\u5747\u80fd\u8f83\u597d\u7684\u9002\u5e94\u53cd\u5e94\u6761\u4ef6\uff0c\u80fd\u591f\u4ee5\u826f\u597d\u81f3\u4f18\u826f\u7684\u6536\u7387\u3001\u5bf9\u6620\u9009\u62e9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u975e\u5bf9\u6620\u9009\u62e9\u6027\u83b7\u5f97\u76f8\u5e94\u4ea7\u7269\u30021\u4f4d\u6742\u82b3\u57fa\u53d6\u4ee3\u7684\u5185\u6d88\u65cb4,5-\u73af\u6c27\u73af\u5e9a\u80fa\u540c\u6837\u53ef\u4ee5\u53c2\u4e0e\u53cd\u5e94\uff0c\u7136\u800c\uff0c\u4ea7\u7387\u51fa\u73b0\u8f83\u4e3a\u663e\u8457\u5730\u964d\u4f4e\u76f8\u5e94\u4ea7\u7269\u7684\u6536\u7387\u4f1a\u660e\u663e\u964d\u4f4e\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u53d1\u73b0\u6709\u4e00\u90e8\u5206\u6c28\u57fa\u73af\u6c27\u5316\u7269\u5f88\u96be\u83b7\u53d6\u5230\u7edd\u5bf9\u5355\u4e00\u624b\u6027\u7eaf\u7684\u8bd5\u5242\u8fdb\u884c\u7814\u7a76\uff0c\u8fd9\u65f6\u5c31\u4e0d\u53ef\u907f\u514d\u5730\u8981\u91c7\u75281,5-cis-\u4e0e1,5-trans-\u6c28\u57fa\u73af\u6c27\u5316\u7269\u7684\u975e\u5bf9\u6620\u6df7\u5408\u7269\u8fdb\u884c\u5b9e\u9a8c\u7814\u7a76\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-28.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33460 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-28.jpg\" alt=\"\" width=\"446\" height=\"615\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-28.jpg 446w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-28-218x300.jpg 218w\" sizes=\"(max-width: 446px) 100vw, 446px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Table 2\u5e95\u7269\u6269\u5c55<\/p>\n<p>\u4e3a\u4e86\u8bc1\u660e\u53cd\u5e94\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u4e00\u7cfb\u5217\u76f8\u5173\u4ea7\u7269\u7684\u5408\u6210\u5e94\u7528\u7814\u7a76\uff08Scheme 2\uff09\u3002\u7814\u7a76\u8868\u660e\uff0c<strong>2a<\/strong>\u7ecf\u5386\u7b80\u5355\u7684<em>N<\/em>-\u53bb\u7532\u82ef\u78fa\u9170\u5316\u53cd\u5e94\u3001<em>N<\/em>-\u7532\u57fa\u5316\u53cd\u5e94\u5c31\u53ef\u8f6c\u5316\u4e3a(-)-\u03b1-tropanol\u3002\u540c\u65f6\uff0c<strong>2a<\/strong>\u4f9d\u6b21\u7ecf\u8fc7\u9187\u6c27\u5316\u53cd\u5e94\u3001\u7094\u57fa\u5316\u53cd\u5e94\u3001Rupe\u91cd\u6392\u53cd\u5e94\u4ee5\u53ca<em>N<\/em>-\u8131\u7532\u82ef\u78fa\u9170\u5316\/<em>N<\/em>-\u7532\u57fa\u5316\u53cd\u5e94\u53ef\u4ee5\u8f6c\u5316\u4e3a\u5929\u7136\u4ea7\u7269(+)-ferruginine\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-28.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33461 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-28.jpg\" alt=\"\" width=\"566\" height=\"518\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-28.jpg 566w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-28-300x275.jpg 300w\" sizes=\"(max-width: 566px) 100vw, 566px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 2 \u884d\u751f\u53cd\u5e94<\/p>\n<h4><strong>\u8bba\u6587\u603b\u7ed3\u8bc4\u4ef7<\/strong><\/h4>\n<p>\u897f\u73ed\u7259Basque\u5927\u5b66Uria\u3001Vicario\u56e2\u961f\u548c\u897f\u73ed\u7259Zaragoza\u5927\u5b66Merino\u56e2\u961f\u5171\u540c\u62a5\u9053\u4e86\u624b\u6027\u78f7\u9178\u50ac\u5316\u5185\u6d88\u65cb\u73af\u70ef\u80fa\u884d\u751f\u7684\u73af\u6c27\u5316\u7269\u7684\u4e0d\u5bf9\u79f0\u53bb\u5bf9\u79f0\u5316\u53cd\u5e94\uff0c\u80fd\u4ee5\u826f\u597d\u81f3\u4f18\u826f\u7684\u6536\u7387\u3001\u5bf9\u6620\u9009\u62e9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u975e\u5bf9\u6620\u9009\u62e9\u6027\u83b7\u5f97\u4e00\u7cfb\u5217\u624b\u6027\u6258\u70f7\u7c7b\u5316\u5408\u7269\u3002\u540c\u65f6\uff0c\u7ecf\u8fc7\u7b80\u5355\u7684\u884d\u751f\u53cd\u5e94\uff0c\u4f5c\u8005\u6210\u529f\u5b9e\u73b0\u4e86\u5929\u7136\u4ea7\u7269(-)-\u03b1-tropanol\u548c(+)-ferruginine\u7684\u5168\u5408\u6210\u3002\u6b64\u5916\uff0c\u53cd\u5e94\u673a\u7406\u4e0e\u8ba1\u7b97\u7814\u7a76\u8868\u660eN-Ts\u57fa\u56e2\u5bf9\u53cd\u5e94\u7684\u53d1\u751f\u4ee5\u53ca\u5bf9\u6620\u9009\u62e9\u6027\u7684\u63a7\u5236\u8d77\u5173\u952e\u4f5c\u7528\u3002<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] R. P. Reddy, H. M. L. Davies, <em>J. Am. Chem. Soc. <\/em><strong>2007<\/strong>, <em>129<\/em>, 10312. DOI:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja072936e\">10.1021\/ja072936e<\/a><\/li>\n<li>[2] J.-H. Xu, S.-C. Zheng, J.-W. Zhang, X.-Y. Liu, B. Tan, <em>Angew. Chem. Int. Ed. <\/em><strong>2016<\/strong>, <em>55<\/em>, 11834. DOI:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/anie.201605736\">10.1002\/anie.201605736<\/a><\/li>\n<li>[3] D. M. Mans, W. H. Pearson, <em>Org. Lett.<\/em> <strong>2004<\/strong>, <em>6<\/em>, 3305. DOI:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ol048777a\">10.1021\/ol048777a<\/a><\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u80cc\u666f\u4ecb\u7ecd tropane\u662f\u4e00\u7c7b\u5177\u6709\u591a\u6837\u751f\u7269\u6d3b\u6027\u7684\u5929\u7136\u4ea7\u7269\uff0c\u5176\u4e2d\u5927\u591a\u6570\u751f\u7269\u78b1\u90fd\u80fd\u591f\u4e0e\u7ec6\u80de\u7684\u795e\u7ecf\u9012\u8d28\u4e59\u9170\u80c6\u78b1\u76f8\u4e92\u4f5c\u7528\u3002\u81eaRobinson\u9898\u7ec4\u9996\u6b21\u5408\u6210\u6258\u70f7\u7c7b\u751f\u7269\u78b1\u8d77\uff0ctropan\u7684\u4e0d\u5bf9\u79f0\u5408\u6210\u53d6\u5f97\u4e86\u6781\u597d\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u7136\u800c\uff0c\u591a\u6570\u5408\u6210\u65b9\u6cd5\u5c40\u9650\u4e8e\u4e3b\u8981\u5c40\u9650\u4e8e\u624b\u6027\u6258\u70f7\u7c7b\u5316\u5408\u7269\u7684\u533a\u57df\u9009\u62e9\u6027\u53cd\u5e94\u548c\u975e\u624b\u6027\u6258\u70f7\u7c7b\u5316\u5408\u7269\u7684\u53bb\u5bf9\u79f0\u5316\u53cd\u5e94\u3002\u53ea\u6709\u5c11\u6570\u4e0d\u5bf9\u79f0\u5408\u62108-\u6c2e\u6742\u53cc\u73af[3.2.1]\u8f9b\u70f7\u7c7b\u5316\u5408\u7269\u7684\u62a5\u9053\u662f\u5173\u4e8e\u624b\u6027Rh(II)\u50ac\u5316\u4e0b\u5421\u54af\u548c\u70ef\u9187\u91cd\u6c2e\u4e59\u9178\u916f\u7684\u4e0d\u5bf9\u79f0[4+3]\u73af\u52a0\u6210\u53cd\u5e94[1]\u3001\u5f02\u55b9\u5549\u884d\u751f\u7684\u5076\u6c2e\u7532\u4e9a\u80fa\u4e0d\u5bf9\u79f01,3-\u5076\u6781\u73af\u52a0\u6210\u53cd\u5e94[2]\u4ee5\u53caL-\u812f\u6c28\u9178\u50ac\u5316\u5185\u6d88\u65cb-N-\u53d4\u4e01\u6c27\u7fb0\u57fa-(\u5421\u54af\u70f7-2,5-\u4e8c\u57fa)\u4e8c\u4e59\u919b\u7684\u4e0d\u5bf9\u79f0\u5206\u5b50\u5185\u7f9f\u919b\u53cd\u5e94[3]\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7814\u7a76\u80cc\u666f\u7684\u57fa\u7840\u4e0a\uff0c\u897f\u73ed\u7259Basque\u5927\u5b66Uria\u3001Vicario\u56e2\u961f\u548c\u897f\u73ed\u7259Basque\u5927\u5b66Merino\u56e2\u961f\u5171\u540c\u62a5\u9053\u4e86Br\u00f8nsted\u9178\u50ac\u5316\u5185\u6d88\u65cb\u73af\u70ef\u80fa\u884d\u751f\u7684\u73af\u6c27\u5316\u7269\u7684\u4e0d\u5bf9\u79f0\u5206\u5b50\u5185\u5f00\u73af\u53cd\u5e94\uff0c\u80fd\u591f\u4ee5\u826f\u597d\u81f3\u4f18\u79c0\u7684\u6536\u7387\u3001\u5bf9\u6620\u9009\u62e9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u975e\u5bf9\u6620\u9009\u62e9\u6027\u83b7\u5f97\u4e00\u7cfb\u5217\u624b\u60278-\u6c2e\u6742\u53cc\u73af[3.2.1]\u8f9b\u70f7\u7c7b\u5316\u5408\u7269\uff08Scheme 1\uff09\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e \u201cEnantioselective Synthesis of Tropanes: Br\u00f8nsted Acid-Catalyzed Pseudotransannular Desymmetrization\u201d S. Rodriguez, U. Uria,* E. Reyes, L. Carrillo, T. Tejero, P. Merino*, J. L. Vicario* Angew. Chem. Int. Ed. 2020, 59, 6780. DOI: 10.1002\/anie.202000650 Scheme 1 \u80cc\u666f\u7814\u7a76 \u8bba\u6587\u6982\u8981 \u4ee5\u73af\u6c27\u73af\u5e9a\u80fa1a\u4e3a\u6a21\u677f\u5e95\u7269\uff0c\u4f5c\u8005\u73af\u6c27\u73af\u5e9a\u80fa\u4e2d\u6c28\u57fa\u4fdd\u62a4\u57fa\u3001\u50ac\u5316\u5242\u4ee5\u53ca\u6eb6\u5242\u7b49\u53cd\u5e94\u6761\u4ef6\u8fdb\u884c\u53cd\u590d\u7b5b\u9009\uff0c\u786e\u5b9a\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\uff08Table 1\uff09\uff1a1a\u4e3a\u5e95\u7269\uff0c5 mol% 3g\u4e3a\u50ac\u5316\u5242\uff0c\u7532\u82ef\u4e3a\u6eb6\u5242\uff0c\u5728-20\u2103\u6761\u4ef6\u4e0b\u53cd\u5e9412\u5c0f\u65f6\uff0c\u80fd\u591f\u4ee595%\u7684\u6536\u7387\u548c94%\u7684\u5bf9\u6620\u9009\u62e9\u6027\u83b7\u5f97\u4ea7\u72692a\u3002\u82e5\u5c06\u66f4\u6362\u6c2f\u82ef\u4f5c\u4e3a\u6eb6\u5242\uff0c\u540c\u6837\u80fd\u591f\u4ee593%\u7684\u6536\u7387\u548c92%\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u4ea7\u72692a\u3002 Table 1 \u6761\u4ef6\u7b5b\u9009 \u5728\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u4e86\u8003\u5bdf\uff08Table 2\uff09\u3002\u7814\u7a76\u53d1\u73b0\u4ee5\u7532\u82ef\u6216\u6c2f\u82ef\u4f5c\u4e3a\u6eb6\u5242\uff0c1\u4f4d\u70f7\u57fa\u53d6\u4ee3\u6216\u82b3\u57fa\u53d6\u4ee3\u7684\u5185\u6d88\u65cb4,5-\u73af\u6c27\u73af\u5e9a\u80fa\u5747\u80fd\u8f83\u597d\u7684\u9002\u5e94\u53cd\u5e94\u6761\u4ef6\uff0c\u80fd\u591f\u4ee5\u826f\u597d\u81f3\u4f18\u826f\u7684\u6536\u7387\u3001\u5bf9\u6620\u9009\u62e9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u975e\u5bf9\u6620\u9009\u62e9\u6027\u83b7\u5f97\u76f8\u5e94\u4ea7\u7269\u30021\u4f4d\u6742\u82b3\u57fa\u53d6\u4ee3\u7684\u5185\u6d88\u65cb4,5-\u73af\u6c27\u73af\u5e9a\u80fa\u540c\u6837\u53ef\u4ee5\u53c2\u4e0e\u53cd\u5e94\uff0c\u7136\u800c\uff0c\u4ea7\u7387\u51fa\u73b0\u8f83\u4e3a\u663e\u8457\u5730\u964d\u4f4e\u76f8\u5e94\u4ea7\u7269\u7684\u6536\u7387\u4f1a\u660e\u663e\u964d\u4f4e\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u53d1\u73b0\u6709\u4e00\u90e8\u5206\u6c28\u57fa\u73af\u6c27\u5316\u7269\u5f88\u96be\u83b7\u53d6\u5230\u7edd\u5bf9\u5355\u4e00\u624b\u6027\u7eaf\u7684\u8bd5\u5242\u8fdb\u884c\u7814\u7a76\uff0c\u8fd9\u65f6\u5c31\u4e0d\u53ef\u907f\u514d\u5730\u8981\u91c7\u75281,5-cis-\u4e0e1,5-trans-\u6c28\u57fa\u73af\u6c27\u5316\u7269\u7684\u975e\u5bf9\u6620\u6df7\u5408\u7269\u8fdb\u884c\u5b9e\u9a8c\u7814\u7a76\u3002 Table 2\u5e95\u7269\u6269\u5c55 \u4e3a\u4e86\u8bc1\u660e\u53cd\u5e94\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u4e00\u7cfb\u5217\u76f8\u5173\u4ea7\u7269\u7684\u5408\u6210\u5e94\u7528\u7814\u7a76\uff08Scheme 2\uff09\u3002\u7814\u7a76\u8868\u660e\uff0c2a\u7ecf\u5386\u7b80\u5355\u7684N-\u53bb\u7532\u82ef\u78fa\u9170\u5316\u53cd\u5e94\u3001N-\u7532\u57fa\u5316\u53cd\u5e94\u5c31\u53ef\u8f6c\u5316\u4e3a(-)-\u03b1-tropanol\u3002\u540c\u65f6\uff0c2a\u4f9d\u6b21\u7ecf\u8fc7\u9187\u6c27\u5316\u53cd\u5e94\u3001\u7094\u57fa\u5316\u53cd\u5e94\u3001Rupe\u91cd\u6392\u53cd\u5e94\u4ee5\u53caN-\u8131\u7532\u82ef\u78fa\u9170\u5316\/N-\u7532\u57fa\u5316\u53cd\u5e94\u53ef\u4ee5\u8f6c\u5316\u4e3a\u5929\u7136\u4ea7\u7269(+)-ferruginine\u3002 Scheme 2 \u884d\u751f\u53cd\u5e94 \u8bba\u6587\u603b\u7ed3\u8bc4\u4ef7 \u897f\u73ed\u7259Basque\u5927\u5b66Uria\u3001Vicario\u56e2\u961f\u548c\u897f\u73ed\u7259Zaragoza\u5927\u5b66Merino\u56e2\u961f\u5171\u540c\u62a5\u9053\u4e86\u624b\u6027\u78f7\u9178\u50ac\u5316\u5185\u6d88\u65cb\u73af\u70ef\u80fa\u884d\u751f\u7684\u73af\u6c27\u5316\u7269\u7684\u4e0d\u5bf9\u79f0\u53bb\u5bf9\u79f0\u5316\u53cd\u5e94\uff0c\u80fd\u4ee5\u826f\u597d\u81f3\u4f18\u826f\u7684\u6536\u7387\u3001\u5bf9\u6620\u9009\u62e9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u975e\u5bf9\u6620\u9009\u62e9\u6027\u83b7\u5f97\u4e00\u7cfb\u5217\u624b\u6027\u6258\u70f7\u7c7b\u5316\u5408\u7269\u3002\u540c\u65f6\uff0c\u7ecf\u8fc7\u7b80\u5355\u7684\u884d\u751f\u53cd\u5e94\uff0c\u4f5c\u8005\u6210\u529f\u5b9e\u73b0\u4e86\u5929\u7136\u4ea7\u7269(-)-\u03b1-tropanol\u548c(+)-ferruginine\u7684\u5168\u5408\u6210\u3002\u6b64\u5916\uff0c\u53cd\u5e94\u673a\u7406\u4e0e\u8ba1\u7b97\u7814\u7a76\u8868\u660eN-Ts\u57fa\u56e2\u5bf9\u53cd\u5e94\u7684\u53d1\u751f\u4ee5\u53ca\u5bf9\u6620\u9009\u62e9\u6027\u7684\u63a7\u5236\u8d77\u5173\u952e\u4f5c\u7528\u3002 \u53c2\u8003\u6587\u732e [1] R. P. Reddy, H. M. L. Davies, J. Am. Chem. Soc. 2007, 129, 10312. DOI:10.1021\/ja072936e [2] J.-H. Xu, S.-C. Zheng, J.-W. Zhang, X.-Y. Liu, B. Tan, Angew. Chem. Int. Ed. 2016, 55, 11834. DOI:10.1002\/anie.201605736 [3] D. M. Mans, W. H. Pearson, Org. Lett. 2004, 6, 3305. 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