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Chem. 2018, 83, 2198. doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.joc.7b03098\">10.1021\/acs.joc.7b03098<\/a>.<strong>\u00a0<\/strong><\/li>\n<\/ul>\n<h4><strong>\u53cd\u5e94\u673a\u7406<\/strong><\/h4>\n<p><strong>\u70ef\u70c3\u53c2\u4e0e\u7684<\/strong><strong>Heck-Matsuda<\/strong><strong>\u53cd\u5e94<\/strong><sup>[1]-[7], [11]-[12]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-43.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33488 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-43.jpg\" alt=\"\" width=\"1087\" height=\"947\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-43.jpg 1087w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-43-300x261.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-43-680x592.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-43-768x669.jpg 768w\" sizes=\"(max-width: 1087px) 100vw, 1087px\" \/><\/a><\/p>\n<p><strong>\u4e59\u70ef\u57fa\u4e09\u7532\u57fa\u7845\u70f7\u53c2\u4e0e\u7684<\/strong><strong>Heck-Matsuda<\/strong><strong>\u53cd\u5e94<\/strong><sup>[8]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-34.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33489 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-34.jpg\" alt=\"\" width=\"1231\" height=\"854\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-34.jpg 1231w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-34-300x208.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-34-680x472.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-34-768x533.jpg 768w\" sizes=\"(max-width: 1231px) 100vw, 1231px\" \/><\/a><\/p>\n<p><strong>N-<\/strong><strong>\u4e9a\u785d\u57fa<\/strong><strong>-N-<\/strong><strong>\u82b3\u57fa\u4e59\u9170\u80fa\u5f02\u6784\u5316\u539f\u4f4d\u751f\u6210\u82b3\u9999\u91cd\u6c2e\u76d0<\/strong><sup>[9]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-30.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33490 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-30.jpg\" alt=\"\" width=\"918\" height=\"180\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-30.jpg 918w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-30-300x59.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-30-680x133.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-30-768x151.jpg 768w\" sizes=\"(max-width: 918px) 100vw, 918px\" \/><\/a><\/p>\n<p><strong>\u03b1-<\/strong><strong>\u82ef\u4e59\u70ef\u57fa\u9521\u70f7\u53c2\u4e0e\u7684<\/strong><strong>Heck-Matsuda<\/strong><strong>\u53cd\u5e94<\/strong><sup>[10]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-30.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33491 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-30.jpg\" alt=\"\" width=\"1376\" height=\"619\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-30.jpg 1376w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-30-300x135.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-30-680x306.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-30-768x345.jpg 768w\" sizes=\"(max-width: 1376px) 100vw, 1376px\" \/><\/a><\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] Sutton, D. Chem. Rev. 1993, 93, 995. doi:<a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/cr00019a008\"> 10.1021\/cr00019a008.<\/a><\/li>\n<li>[2] R. B. King, J. Organomet. Chem. 1995, 500, 187. doi: <a href=\"https:\/\/doi.org\/10.1016\/0022-328X(95)00504-J\">10.1016\/0022-328X(95)00504-J<\/a>.<\/li>\n<li>[3] R. Yamashita, K. Kikukawa, F. Wada, T. Matsuda, J. Organomet. Chem. 1980, 201, 463. doi: <a href=\"https:\/\/doi.org\/10.1016\/S0022-328X(00)87932-2\">10.1016\/S0022-328X(00)87932-2<\/a>.<\/li>\n<li>[4] A. Pla-Quintana, A. Roglans, ARKIVOC 2005, ix, 51. doi: <a href=\"https:\/\/doi.org\/10.3998\/ark.5550190.0006.907\">10.3998\/ark.5550190.0006.907<\/a>.<\/li>\n<li>[5] F.-X. Felpin, K. Miqueu, J.-M. Sotiropoulos, E. Fouquet, O. Ibarguren, J. Laudien, Chem.-Eur. J. 2010, 16, 5191. doi: <a href=\"https:\/\/doi.org\/10.1002\/chem.200903050\">10.1002\/chem.200903050<\/a> .<\/li>\n<li>[6] N. Susperregui, K. Miqueu, J.-M. Sotiropoulos, F. Le\u2005Callonnec, E. Fouquet, F.-X. Felpin, Chem.-Eur. J. 2012, 18, 7210. doi: <a href=\"https:\/\/doi.org\/10.1002\/chem.201200444\">10.1002\/chem.201200444<\/a>.<\/li>\n<li>[7] A. H. L. Machado, H. M. S. Milagre, L. S. Eberlin, A. A. Sabino, C. R. D. Correia, M. N. Eberlin, Org. Biomol. Chem. 2013, 11, 3277. doi: <a href=\"https:\/\/doi.org\/10.1039\/C3OB40142A\">10.1039\/C3OB40142A<\/a>.<\/li>\n<li>[8] K. Kikukawa, K. Ikenaga, K. Kono, K. Toritani, F. Wada, T. Matsuda, J. Organomet. Chem. 1984, 270, 277. doi: <a href=\"https:\/\/sci-hub.tw\/10.1016\/0022-328x%2884%2980374-5\">10.1016\/0022-328X(84)80374-5.<\/a><\/li>\n<li>[9] K. Kikukawa, M. Naritomi, G. He, F. Wada, T. Matsuda, J. Org. Chem. 1985, 50, 299. doi: <a href=\"https:\/\/doi.org\/10.1021\/jo00203a003\">10.1021\/jo00203a003<\/a>.<\/li>\n<li>[10] K. Kikukawa, H. Umekawa, T. Matsuda, J. Organomet. Chem. 1986, 311, C44. doi: <a href=\"https:\/\/doi.org\/10.1016\/0022-328X(86)80264-9\">10.1016\/0022-328X(86)80264-9<\/a>.<\/li>\n<li>[11] K. S. Reddy, B. Siva, S. D. Reddy, N. R. Naresh, T.V. Pratap, B. V. Rao, Y. Hong, B. V. Kumar, A. K. Raju, P. M. Reddy, A. Hu, Molecules 2020, 25, 2199. doi: <a href=\"https:\/\/doi.org\/10.3390\/molecules25092199\">10.3390\/molecules25092199<\/a>.<\/li>\n<li>[12] A. A. Sabino, A. H. L. Machado, C. R. D. Correia, M. N. Eberlin, Angew. Chem. Int. Ed. 2004, 43, 2514. doi: <a href=\"https:\/\/doi.org\/10.1002\/anie.200353076\">10.1002\/anie.200353076<\/a>.<\/li>\n<\/ul>\n<h4><strong>\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/h4>\n<p>\u5171\u8f6d\u805a\u5408\u7269\u7684\u5408\u6210<sup>[1]-[2]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-44.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33492 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-44.jpg\" alt=\"\" width=\"1273\" height=\"825\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-44.jpg 1273w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-44-300x194.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-44-680x441.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/1-44-768x498.jpg 768w\" sizes=\"(max-width: 1273px) 100vw, 1273px\" \/><\/a><\/p>\n<p>(R)-tolterodine\u7684\u5408\u6210<sup>[3]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-35.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33493 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-35.jpg\" alt=\"\" width=\"971\" height=\"382\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-35.jpg 971w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-35-300x118.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-35-680x268.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/2-35-768x302.jpg 768w\" sizes=\"(max-width: 971px) 100vw, 971px\" \/><\/a><\/p>\n<p>\u82b3\u57faC-\u7cd6\u82f7\u7684\u5408\u6210<sup>[4]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-31.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33494 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-31.jpg\" alt=\"\" width=\"1087\" height=\"210\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-31.jpg 1087w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-31-300x58.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-31-680x131.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/3-31-768x148.jpg 768w\" sizes=\"(max-width: 1087px) 100vw, 1087px\" \/><\/a><\/p>\n<p>\u82b3\u57faSF<sub>5<\/sub>\u5316\u5408\u7269\u7684\u5408\u6210<sup>[5]<\/sup><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-31.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-33495 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-31.jpg\" alt=\"\" width=\"1083\" height=\"128\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-31.jpg 1083w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-31-300x35.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-31-680x80.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/06\/4-31-768x91.jpg 768w\" sizes=\"(max-width: 1083px) 100vw, 1083px\" \/><\/a><\/p>\n<h4><strong>\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/h4>\n<p><span style=\"color: #0000ff;\"><strong>\u70ef\u57fa\u5316\u5408\u7269\u53c2\u4e0e\u7684<\/strong><strong>Heck-Matsuda<\/strong><strong>\u53cd\u5e94<\/strong><\/span><\/p>\n<p>\u5ba4\u6e29\u4e0b\uff0c\u5411\u94af\u50ac\u5316\u5242 (0.02 eq.)\u3001\u4e59\u9178\u94a0 (3 eq.)\u3001\u70ef\u57fa\u5316\u5408\u7269(2 eq.)\u7684\u4e59\u8148\u6eb6\u6db2 (\u6d53\u5ea6\u4e3a 0.625M)\u4e2d\u52a0\u5165\u56db\u6c1f\u787c\u9178\u82b3\u9999\u91cd\u6c2e\u76d0 (1 eq.)\uff0c\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u8fdb\u884c\u6405\u62cc\u3002\u6b64\u65f6\uff0c\u89c2\u5bdf\u5230\u6709\u5927\u91cf\u6c14\u4f53 (\u6c2e\u6c14)\u4ea7\u751f\u3002\u5f53\u6c14\u4f53\u4e0d\u518d\u4ea7\u751f\u65f6\uff0c\u5411\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u4e2d\u52a0\u5165\u9971\u548c\u78b3\u9178\u94a0\u6eb6\u6db2\uff0c\u518d\u7ee7\u7eed\u6405\u62cc1h\u3002\u968f\u540e\uff0c\u52a0\u5165\u9002\u91cf\u4e59\u919a\u8fdb\u884c\u8403\u53d6\u3002\u5c06\u5408\u5e76\u7684\u6709\u673a\u76f8\u4f9d\u6b21\u901a\u8fc7\u9971\u548c\u6c2f\u5316\u94a0\u6eb6\u6db2\u6d17\u6da4\u4e0e\u65e0\u6c34\u786b\u9178\u9541\u5e72\u71e5\u3002\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u540e\uff0c\u5c06\u7c97\u4ea7\u7269\u901a\u8fc7\u7845\u80f6\u67f1\u8272\u8c31\u6216\u901a\u8fc7\u51cf\u538b\u84b8\u998f\u8fdb\u884c\u7eaf\u5316\uff0c\u83b7\u5f97\u76f8\u5e94\u5076\u8054\u4ea7\u7269\u3002<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] F. Babudri, G. M. Farinola, L. C. Lopez, M. G. Martinelli, F. Naso, J. Org. Chem. 2001, 66, 3878. doi: <a href=\"https:\/\/sci-hub.tw\/10.1021\/jo001795v\">10.1021\/jo001795v.<\/a><\/li>\n<li>[2] R. Ancora, F. Babudri, G. M. Farinola, F. Naso, R. Ragni, Eur. J. Org. Chem. 2002, 4127. doi: <a href=\"https:\/\/sci-hub.tw\/10.1002\/1099-0690%28200212%292002%3A24%3C4127%3A%3Aaid-ejoc4127%3E3.0.co%3B2-z\">10.1002\/1099-0690(200212)2002:24&lt;4127::aid-ejoc4127&gt;3.0.co;2-z.<\/a><\/li>\n<li>[3] D. A. Barancelli, A. G. Salles, J. G. Taylor, C. R. D. Correia, Org. Lett. 2012, 14, 6036. doi: <a href=\"https:\/\/doi.org\/10.1021\/ol302923f\">10.1021\/ol302923f<\/a>.<\/li>\n<li>[4] A. K. Singh, J. Kandasamy, Org. Biomol. Chem. 2018, 16, 5107. doi: <a href=\"https:\/\/doi.org\/10.1039\/C8OB01393D\">10.1039\/C8OB01393D<\/a>.<\/li>\n<li>[5] T. Okazaki, K. K. Laali, S. D. Bunge, S. K. Adas, Eur. J. Org. Chem. 2014, 1630. doi: <a href=\"https:\/\/doi.org\/10.1002\/ejoc.201301538\">10.1002\/ejoc.201301538<\/a>.<\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 1977\u5e74\u65e5\u672cKyushu\u5927\u5b66\u7684Matsuda (\u677e\u7530 \u6634,\u4e5d\u5dde\u5927\u5b66\u5de5\u5b66\u90e8\u5408\u6210\u5316\u5b66\u79d1, Matsuda Tsutomu, Department of Organic Synthesis, Faculty of Engineering, Kyushu University)\u7814\u7a76\u5ba4\u9996\u6b21\u62a5\u9053\u4e86\u7531\u94af\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u6c2f\u5316\u82b3\u9999\u91cd\u6c2e\u76d0\u4e0e\u5404\u7c7b\u4f9b\u7535\u5b50\u57fa\u56e2\u53d6\u4ee3\u70ef\u70c3\u4e4b\u95f4\u7684\u4ea4\u53c9\u5076\u8054\u8fc7\u7a0b\uff0c\u6210\u529f\u5b9e\u73b0\u76f8\u5e94\u4f9b\u7535\u5b50\u57fa\u53d6\u4ee3\u70ef\u70c3\u7684\u82b3\u57fa\u5316[1]\u3002\u8be5\u53cd\u5e94\u6761\u4ef6\u5bf9\u4e8e\u82ef\u4e59\u70ef\u5e95\u7269\u5177\u6709\u8f83\u597d\u7684(E)-\u9009\u62e9\u6027\uff0c\u7136\u800c\uff0c\u53cd\u5e94\u4ea7\u7387\u4e2d\u7b49\u3002 \u4e4b\u540e\uff0cMatsuda\u91c7\u7528\u56db\u6c1f\u787c\u9178\u82b3\u9999\u91cd\u6c2e\u76d0\uff0c\u5c06\u5e95\u7269\u6269\u5c55\u81f3\u4e59\u70ef\uff0c\u5e76\u6210\u529f\u5b9e\u73b04\u02b9-\u4e59\u70ef\u57fa\u82ef\u5e76-15-\u51a0-5\u7684\u5408\u6210[2]\u3002 1979\u5e74\uff0cMatsuda\u5bf9\u5176\u5b83\u56db\u6c1f\u787c\u9178\u82b3\u9999\u91cd\u6c2e\u76d0\u4e0e\u4e59\u70ef\u7684\u5076\u8054\u53cd\u5e94\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u987a\u5229\u5b8c\u6210\u5404\u7c7b\u53d6\u4ee3\u82ef\u4e59\u70ef\u7684\u5408\u6210[3]\u3002 1980\u5e74\uff0cMatsuda\u7814\u7a76\u53d1\u73b0\uff0c\u901a\u8fc7\u82b3\u80fa\u4e0e\u4e9a\u785d\u9178\u53d4\u4e01\u916f\u539f\u4f4d\u751f\u6210\u7684\u82b3\u9999\u91cd\u6c2e\u76d0\u5728\u94af\u50ac\u5316\u5242\u5b58\u5728\u4e0b\uff0c\u4e0e\u70ef\u57fa\u5316\u5408\u7269\u53cd\u5e94\uff0c\u540c\u6837\u53ef\u4ee5\u6709\u6548\u5b8c\u6210\u70ef\u70c3\u7684(E)-\u9009\u62e9\u6027\u82b3\u57fa\u5316\u3002\u540c\u65f6\uff0c\u8fd8\u80fd\u591f\u4f7f\u53cd\u5e94\u4ea7\u7387\u83b7\u5f97\u8f83\u5927\u63d0\u9ad8[4]\u3002 1981\u5e74\uff0cMatsuda\u5bf9\u8102\u80aa\u65cf\u70ef\u70c3\uff0c\u73af\u70ef\u70c3\u3001\u70ef\u4e19\u9187\u3001\u82ef\u4e59\u70ef\u53ca\u4e19\u70ef\u9178\u4e59\u916f\u7b49\u5404\u7c7b\u70ef\u57fa\u5e95\u7269\u4e0e\u82b3\u9999\u91cd\u6c2e\u76d0\u4e4b\u95f4\u7684\u5076\u8054\u53cd\u5e94\u8fdb\u884c\u4e86\u6df1\u5165\u7814\u7a76\uff0c\u53d1\u73b0\u5728\u94af\u50ac\u5316\u6761\u4ef6\u4e0b\uff0c\u80fd\u591f\u8f83\u4e3a\u65b9\u4fbf\u5730\u5b9e\u73b0\u4e0a\u8ff0\u5e95\u7269\u7684(E)-\u9009\u62e9\u6027\u82b3\u57fa\u5316[5]\u3002 1984\u5e74\uff0cKikukawa (\u83ca\u5ddd\u3000\u6e05, \u4e5d\u5dde\u5927\u5b66\u5de5\u5b66\u90e8\u5408\u6210\u5316\u5b66\u79d1, Kikukawa Kiyoshi, Department of Organic Synthesis, Faculty of Engineering, Kyushu University)\u5c06Matsuda\u53d1\u5c55\u7684\u5076\u8054\u65b9\u6cd5\u5b66\u5e94\u7528\u4e8e\u4e59\u70ef\u57fa\u4e09\u7532\u57fa\u7845\u70f7\u7684(E)-\u9009\u62e9\u6027\u82b3\u57fa\u5316[6]\u3002 \u4e4b\u540e\uff0cKikukawa\u8fdb\u4e00\u6b65\u5bf9\u94af\u50ac\u5316\u6761\u4ef6\u4e0b\uff0c(E)-\u82ef\u4e59\u70ef\u57fa\u4e09\u7532\u57fa\u7845\u70f7\u53ca(Z)-\u82ef\u4e59\u70ef\u57fa\u4e09\u7532\u57fa\u7845\u70f7\u4e0e\u82b3\u57fa\u91cd\u6c2e\u76d0\u7684\u5076\u8054\u53cd\u5e94\u8fdb\u884c\u4e86\u7cfb\u7edf\u7814\u7a76\uff0c\u53d1\u73b0\u4e8c\u8005\u5747\u83b7\u5f97(E)-\u9009\u62e9\u6027\u82b3\u57fa\u5316\u4ea7\u7269[7]\u3002 \u540c\u65f6\uff0cKikukawa\u4e0eIkenaga (\u6c60\u6c38\u3000\u548c\u654f,\u718a\u672c\u5de5\u696d\u5927\u5b66\u5de5\u696d\u5316\u5b66\u79d1,Ikenaga Kazutoshi, Department of Industrial Chemistry, Kumamoto Institute of Technology)\u5bf9\u5176\u5b83\u7c7b\u578b\u7684\u82ef\u4e59\u70ef\u57fa\u4e09\u70f7\u57fa\u7845\u70f7\u4e0e\u82b3\u9999\u91cd\u6c2e\u76d0\u5076\u8054\u8fc7\u7a0b\u7684\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u8868\u660e\u91c7\u7528\u5927\u4f4d\u963b\u70f7\u57fa\u53d6\u4ee3\u7684\u7845\u70f7\u5e95\u7269\uff0c\u53ef\u4ee5\u83b7\u5f97\u66f4\u9ad8\u7a0b\u5ea6\u7684\u7acb\u4f53\u9009\u62e9\u6027[8]\u3002 1985\u5e74\uff0cKikukawa\u8fdb\u4e00\u6b65\u5c06N-\u4e9a\u785d\u57fa-N-\u82b3\u57fa\u4e59\u9170\u80fa\u5f02\u6784\u5316\u539f\u4f4d\u751f\u6210\u7684\u82b3\u9999\u91cd\u6c2e\u76d0\uff0c\u5e94\u7528\u4e8e\u70ef\u70c3\u3001\u53d6\u4ee3\u70ef\u70c3\u53ca\u73af\u70ef\u70c3\u7684(E)-\u9009\u62e9\u6027\u82b3\u57fa\u5316[9]\u3002 1986\u5e74\uff0cKikukawa\u7814\u7a76\u4e86\u94af\u50ac\u5316\u5242\u6761\u4ef6\u4e0b\uff0c\u5404\u7c7b\u03b1-\u82ef\u4e59\u70ef\u57fa\u9521\u70f7\u4e0e\u82b3\u9999\u91cd\u6c2e\u76d0\u7684\u5076\u8054\u53cd\u5e94\uff0c\u610f\u5916\u5730\u53d1\u73b0\u53cd\u5e94\u8fc7\u7a0b\u4e2d\uff0c\u7acb\u4f53\u9009\u62e9\u6027\u53d1\u751f\u7ffb\u8f6c\uff0c\u83b7\u5f97(Z)-\u4e8c\u82b3\u57fa\u4e59\u70ef[10]\u3002 1995\u5e74\uff0cM. Beller\u901a\u8fc7\u5408\u6210\u4e2d\u5e38\u7528\u7684Pd\/C\u3001Pd\/BaSO4\u53caPd\/Al2O3\u50ac\u5316\u5242\uff0c\u5b8c\u6210\u9996\u4f8b\u7531\u5f02\u76f8\u94af\u50ac\u5316\u5242\u53c2\u4e0e\u7684\u82b3\u9999\u91cd\u6c2e\u76d0\u4e0e\u70ef\u57fa\u5316\u5408\u7269\u4e4b\u95f4\u7684\u4ea4\u53c9\u5076\u8054\u53cd\u5e94[11]\u3002\u540c\u65f6\uff0cM. Beller\u60ca\u559c\u5730\u53d1\u73b0\uff0c\u7531\u4e0a\u8ff0\u5f02\u76f8\u50ac\u5316\u5242\u53c2\u4e0e\u7684\u5076\u8054\u8fc7\u7a0b\u53ef\u4ee5\u5728\u9187\u7c7b\u6eb6\u5242\u4e2d\u987a\u5229\u8fdb\u884c\u3002 1999\u5e74\uff0cJ. P. Gen\u00eat\u5c06\u70ef\u57fa\u5e95\u7269\u6269\u5c55\u81f3\u4e59\u70ef\u57fa\u4e09\u6c1f\u787c\u9178\u94be\uff0c\u4ee5\u826f\u597d\u7684\u4ea7\u7387\u5b8c\u6210\u82ef\u4e59\u70ef\u7684\u5408\u6210[12]\u3002 2000\u5e74\uff0cF. Naso\u91c7\u7528\u4e09\u6c2f\u5316\u787c\u539f\u4f4d\u8f6c\u91d1\u5c5e\u5316\u5f62\u6210\u7684\u70ef\u57fa\u787c\u8bd5\u5242\u4e0e\u82b3\u9999\u91cd\u6c2e\u76d0\u8fdb\u884c\u7684\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\uff0c\u6210\u529f\u5b8c\u6210\u82b3\u57fa\u4e59\u70ef\u7684\u5408\u6210\u3002\u8be5\u65b9\u6cd5\u5177\u6709\u9ad8\u5ea6\u7684\u533a\u57df\u53ca\u7acb\u4f53\u9009\u62e9\u6027[13]\u3002 \u6587\u732e\u4e2d\u5c06\u8fd9\u79cd\u94af\u50ac\u5316\u5242\u53c2\u4e0e\u7684\u82b3\u9999\u91cd\u6c2e\u76d0\u4e0e\u5404\u7c7b\u70ef\u57fa\u5316\u5408\u7269\u4e4b\u95f4\u7684\u4ea4\u53c9\u5076\u8054\u8fc7\u7a0b\uff0c\u5f62\u6210\u82b3\u57fa\u70ef\u70c3\u6216\u82b3\u57fa\u53d6\u4ee3\u7684\u03b1, \u03b2-\u4e0d\u9971\u548c\u5316\u5408\u7269\u7684\u53cd\u5e94\u79f0\u4e3aHeck-Matsuda\u53cd\u5e94 (Heck-Matsuda reaction)\u6216Matsuda\u53cd\u5e94 (Matsuda reaction)\u6216Heck-Matsuda\u82b3\u57fa\u5316 (Heck-Matsuda arylation)\u3002\u8be5\u53cd\u5e94\u662f\u5bf9Heck-Mizoroki (\u6e9d\u5442\u6728 \u52c9,\u6771\u4eac\u5de5\u696d\u5927\u5b66\u8cc7\u6e90\u5316\u5b66\u7814\u7a76\u6240,Mizoroki Tsutomu, Research laboratory of Resources Utilization, Tokyo Institute of \u00a0Techonology)\u53cd\u5e94\u7684\u6709\u529b\u8865\u5145\u3002\u540c\u65f6\uff0c\u8be5\u65b9\u6cd5\u5b66\u4e0eMeerwein\u82b3\u57fa\u5316\u53cd\u5e94 (Meerwein arylation)\u5f62\u6210\u4e92\u8865[1]\u3002\u76ee\u524d\uff0c\u8be5\u53cd\u5e94\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5404\u7c7b\u70ef\u57fa\u5316\u5408\u7269\u4e2d\u53cc\u952e\u7684\u82b3\u57fa\u5316[1]-[19]\u3001\u5404\u7c7b\u7cd6\u82f7[20]-[22]\u3001\u836f\u7269[23]-[25]\u53ca\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210[26]-[35]\u7684\u5173\u952e\u6b65\u9aa4\u3002\u7531\u4e8e\u7bc7\u5e45\u9650\u5236\uff0c\u5bf9\u4e8e\u8be5\u53cd\u5e94\u7684\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\uff0c\u5c0f\u7f16\u5c06\u5728\u4e0b\u4e00\u671f\u8fdb\u884c\u8be6\u7ec6\u4ecb\u7ecd\u3002 \u57fa\u672c\u6587\u732e [1] K. Kikukawa, T. Matsuda, Chem. Lett. 1977, 159. doi: 10.1246\/cl.1977.159. [2] K. Kikukawa, K. Nagira, T. Matsuda, Bull. Chem. Soc. Jpn. 1977, 50, 2207. doi: 10.1246\/bcsj.50.2207. [3] K. Kikukawa, K. 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