{"id":34042,"date":"2020-08-02T08:00:48","date_gmt":"2020-08-02T00:00:48","guid":{"rendered":"\/\/www.gsbet888.com\/?p=34042"},"modified":"2020-07-31T20:25:29","modified_gmt":"2020-07-31T12:25:29","slug":"%e4%b8%ad%e6%9d%91-%e6%b5%a9%e4%b9%8b-hiroyuki-nakamura","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/2020\/08\/%e4%b8%ad%e6%9d%91-%e6%b5%a9%e4%b9%8b-hiroyuki-nakamura.html","title":{"rendered":"\u4e2d\u6751 \u6d69\u4e4b Hiroyuki Nakamura"},"content":{"rendered":"<p>\u672c\u6587\u7ffb\u8bd1\u81ea\u65e5\u6587\u7248\u5316\u5b66\u7a7a\u95f4\uff1a<a href=\"https:\/\/www.chem-station.com\/chemist-db\/2017\/10\/hiroyuki-nakamura.html\">\u4e2d\u6751 \u6d69\u4e4b Hiroyuki Nakamura\u00a0<\/a> \u00a0\u539f\u4f5c\u8005\uff1acosine<\/p>\n<p><strong>\u7ffb\u8bd1\uff1aAlberto Caeiro\uff0c\u6821\u5bf9\uff1aHu Hao<\/strong><\/p>\n<p>\u4e2d\u6751 \u6d69\u4e4b (Hiroyuki Nakamura\uff0c1967\u5e74-)\uff0c\u65e5\u672c\u6709\u673a\u5316\u5b66\u5bb6\uff0c\u751f\u7269\u6709\u673a\u5316\u5b66\u5bb6\uff0c\u73b0\u4e3a\u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66 \u79d1\u5b66\u6280\u672f\u521b\u6210\u7814\u7a76\u9662 \u5316\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u6559\u6388\uff0c\u56fe\u7247\uff1a<a href=\"http:\/\/syn.res.titech.ac.jp\/en\/groupmembers\/staff_studenets\/\">\u5b9e\u9a8c\u5ba4\u4ecb\u7ecd<\/a>\u3002<\/p>\n<h4><strong>\u7ecf\u5386<\/strong><\/h4>\n<ul>\n<li>1991 \u5b66\u58eb\uff0c\u4e1c\u5317\u5927\u5b66 (Tohoku University)<\/li>\n<li>1993 \u4fee\u58eb\uff0c\u4e1c\u5317\u5927\u5b66\u5927\u5b66\u9662 \u7406\u5b66\u7814\u7a76\u79d1\u5316\u5b66\u5c02\u653b<\/li>\n<li>1993 Exchange Student\uff0cUniversity of Wales, UK Advisor: Prof. K. Smith<\/li>\n<li>1995 \u7814\u7a76\u52a9\u7406\uff0c\u4e1c\u5317\u5927\u5b66\u5927\u5b66\u9662 \u7406\u5b66\u7814\u7a76\u79d1\u5316\u5b66\u5c02\u653b<\/li>\n<li>1995-1997 \u7814\u7a76\u52a9\u7406\uff0c\u4e5d\u5dde\u5927\u5b66 \u6709\u673a\u5316\u5b66\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/li>\n<li>1996 \u535a\u58eb\uff0c\u6771\u5317\u5927\u5b66\u5927\u5b66\u9662 \u7406\u5b66\u7814\u7a76\u79d1\u5316\u5b66\u5c02\u653b<\/li>\n<li>2002-2006 \u52a9\u7406\u6559\u6388\uff0c\u5b66\u4e60\u9662\u5927\u5b66 \u7406\u5b66\u90e8\u5316\u5b66\u79d1<\/li>\n<li>2006-2013 \u6559\u6388\uff0c\u5b66\u4e60\u9662\u5927\u5b66 \u7406\u5b66\u90e8\u5316\u5b66\u79d1<\/li>\n<li>2013-\u73b0\u5728 \u6559\u6388\uff0c\u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66<\/li>\n<li>2015-\u73b0\u5728 \u4f1a\u957f\uff0c\u65e5\u672c\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u5b66\u4f1a<\/li>\n<\/ul>\n<h4><strong>\u83b7\u5956\u7ecf\u5386<\/strong><\/h4>\n<ul>\n<li>1999 \u65e5\u672c\u5316\u5b66\u4f1a\u8fdb\u6b65\u5956<\/li>\n<li>2007 \u764c\u75c7\u76ee\u6807\u6cbb\u7597\u5b66\u4f1a\u5956\u52b1\u5956 (Japanese Society for Neutron Capture Therapy)<\/li>\n<\/ul>\n<h4><strong>\u7814\u7a76\u4ecb\u7ecd<\/strong><\/h4>\n<p><span style=\"color: #0000ff;\"><strong>1. Development of new nanocarrier for boron neutron capture therapy <sup>[1,2]<\/sup><\/strong><\/span><\/p>\n<p>\u787c\u4e2d\u5b50\u4fd8\u83b7\u7597\u6cd5\uff08BNCT\uff09\u662f\u6307\u5bf9\u4eba\u4f53\u65e0\u5bb3\u7684\u4f4e\u70ed\u4e2d\u5b50\u88ab\u7ec6\u80de\u5185\u7684\u787c\u8bd5\u5242\u6355\u6349\u540e\uff0c<sup>10<\/sup>B\u8f6c\u53d8\u4e3a<sup>11<\/sup>B\u800c\u53d1\u751f\u88c2\u53d8\u4ea7\u751f\u9502\u548c\u03b1\u5c04\u7ebf\uff0c\u4ece\u800c\u901a\u8fc7\u03b1\u5c04\u7ebf\u7834\u574f\u764c\u7ec6\u80de\u7684\u65b0\u578b\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\u3002\u800cNakamura\u6559\u6388\u6b63\u81f4\u529b\u4e8e\u787c\u4e2d\u5b50\u6355\u83b7\u7597\u6cd5\u4e2d\u787c\u7eb3\u7c73\u8f7d\u4f53\u7684\u5f00\u53d1\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/1-36.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-34043 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/1-36.jpg\" alt=\"\" width=\"519\" height=\"532\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/1-36.jpg 519w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/1-36-293x300.jpg 293w\" sizes=\"(max-width: 519px) 100vw, 519px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Boron neutron capture therapy<\/p>\n<p><span style=\"color: #0000ff;\"><strong>2. Protein modification methods based on radical reaction <sup>[3]<\/sup><\/strong><\/span><\/p>\n<p>Nakamura\u6559\u6388\u5229\u7528\u81ea\u7531\u57fa\u7269\u79cd\u5bff\u547d\u77ed\u7684\u6027\u8d28\uff0c\u5f00\u53d1\u4e86\u4e00\u79cd\u901a\u8fc7\u5c40\u90e8\u4ea7\u751f\u81ea\u7531\u57fa\u6765\u9488\u5bf9\u5206\u5b50\u6c61\u67d3\u7269\u7684\u76ee\u6807\u9009\u62e9\u6027\u86cb\u767d\u8d28\u6807\u8bb0\u65b9\u6cd5\u3002\u7279\u522b\u5730\uff0c\u8be5\u65b9\u6cd5\u5728\u542b\u916a\u6c28\u9178\u6b8b\u57fa\u4f53\u7cfb\u4e2d\u6709\u5f88\u597d\u7684\u6548\u679c<sup>[3b,c]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/2-31.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-34044 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/2-31.jpg\" alt=\"\" width=\"679\" height=\"438\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/2-31.jpg 679w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/2-31-300x194.jpg 300w\" sizes=\"(max-width: 679px) 100vw, 679px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Selective labeling of target protein by Ru photocatalyst<\/p>\n<p><span style=\"color: #0000ff;\"><strong>3. Drug discovery based bioactive substances with new skeleton<sup> [4]<\/sup><\/strong><\/span><\/p>\n<p>\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u7684\u6838\u5fc3\u9aa8\u67b6\u5f00\u53d1\u662f\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u91cd\u8981\u4e00\u73af\uff0cNakamura\u6559\u6388\u6b63\u901a\u8fc7\u6709\u673a\u5408\u6210\u65b9\u6cd5\u6765\u5408\u6210\u65b0\u7684\u6846\u67b6\u7ed3\u6784\u7528\u4e8e\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u8bbe\u8ba1\uff0c\u5e76\u5bf9\u5176\u6d3b\u6027\u8fdb\u884c\u8bc4\u4f30\uff0c\u8fdb\u800c\u53cd\u9988\u81f3\u5206\u5b50\u6846\u67b6\u7ed3\u6784\u7684\u8bbe\u8ba1\u4e0e\u5408\u6210\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/3-29.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-34045 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/3-29.jpg\" alt=\"\" width=\"853\" height=\"511\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/3-29.jpg 853w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/3-29-300x180.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/3-29-680x407.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/3-29-768x460.jpg 768w\" sizes=\"(max-width: 853px) 100vw, 853px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Selected examples for bioactive substances with new skeleton<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] For a review, see: Nakamura H. <em>Yakugaku Zasshi<\/em> <strong>2013<\/strong>, <em>133<\/em>, 1297. <a href=\"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/133\/12\/133_13-00222-5\/_article\/-char\/ja\/\">DOI: 10.1248\/yakushi.13-00222-5<\/a>.<\/li>\n<li>[2] a. Nakamura H. <em>Org. Biomol. Chem.<\/em> <strong>2019<\/strong>, <em>17<\/em>, 5496. <a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2019\/ob\/c9ob00584f\/unauth#!divAbstract\">DOI: 10.1039\/C9OB00584F<\/a>; b. Nakamura H. <em>J. Control. Release.<\/em> <strong>2016<\/strong>, 237, 160. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0168365916304515\">DOI: 10.1016\/j.jconrel.2016.07.017<\/a>.<\/li>\n<li>[3] a. Nakamura, H. <em>Angew. Chem. Int. Ed.<\/em> <strong>2013<\/strong>, <em>52<\/em>, 8681. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/anie.201303831\">DOI: 10.1002\/anie.201303831<\/a>; b. Nakamura, H. <em>ACS Chem. Biol<\/em>. <strong>2015<\/strong>, <em>10<\/em>, 2633. <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.5b00440\">DOI: 10.1021\/acschembio.5b00440<\/a>; c. Nakamura, H. <em>ChemBioChem<\/em> <strong>2017<\/strong>, <em>18<\/em>, 475. <a href=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/cbic.201600649\">DOI: 10.1002\/cbic.201600649<\/a>.<\/li>\n<li>[4] For a review, see: Nakamura, H. <em>Chem. Rec.<\/em> <strong>2015<\/strong>, <em>15<\/em>, 616. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/tcr.201402100\">DOI: 10.1002\/tcr.201402100<\/a>.<\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u7ffb\u8bd1\u81ea\u65e5\u6587\u7248\u5316\u5b66\u7a7a\u95f4\uff1a\u4e2d\u6751 \u6d69\u4e4b Hiroyuki Nakamura\u00a0 \u00a0\u539f\u4f5c\u8005\uff1acosine \u7ffb\u8bd1\uff1aAlberto Caeiro\uff0c\u6821\u5bf9\uff1aHu Hao \u4e2d\u6751 \u6d69\u4e4b (Hiroyuki Nakamura\uff0c1967\u5e74-)\uff0c\u65e5\u672c\u6709\u673a\u5316\u5b66\u5bb6\uff0c\u751f\u7269\u6709\u673a\u5316\u5b66\u5bb6\uff0c\u73b0\u4e3a\u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66 \u79d1\u5b66\u6280\u672f\u521b\u6210\u7814\u7a76\u9662 \u5316\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u6559\u6388\uff0c\u56fe\u7247\uff1a\u5b9e\u9a8c\u5ba4\u4ecb\u7ecd\u3002 \u7ecf\u5386 1991 \u5b66\u58eb\uff0c\u4e1c\u5317\u5927\u5b66 (Tohoku University) 1993 \u4fee\u58eb\uff0c\u4e1c\u5317\u5927\u5b66\u5927\u5b66\u9662 \u7406\u5b66\u7814\u7a76\u79d1\u5316\u5b66\u5c02\u653b 1993 Exchange Student\uff0cUniversity of Wales, UK Advisor: Prof. K. Smith 1995 \u7814\u7a76\u52a9\u7406\uff0c\u4e1c\u5317\u5927\u5b66\u5927\u5b66\u9662 \u7406\u5b66\u7814\u7a76\u79d1\u5316\u5b66\u5c02\u653b 1995-1997 \u7814\u7a76\u52a9\u7406\uff0c\u4e5d\u5dde\u5927\u5b66 \u6709\u673a\u5316\u5b66\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3 1996 \u535a\u58eb\uff0c\u6771\u5317\u5927\u5b66\u5927\u5b66\u9662 \u7406\u5b66\u7814\u7a76\u79d1\u5316\u5b66\u5c02\u653b 2002-2006 \u52a9\u7406\u6559\u6388\uff0c\u5b66\u4e60\u9662\u5927\u5b66 \u7406\u5b66\u90e8\u5316\u5b66\u79d1 2006-2013 \u6559\u6388\uff0c\u5b66\u4e60\u9662\u5927\u5b66 \u7406\u5b66\u90e8\u5316\u5b66\u79d1 2013-\u73b0\u5728 \u6559\u6388\uff0c\u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66 2015-\u73b0\u5728 \u4f1a\u957f\uff0c\u65e5\u672c\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u5b66\u4f1a \u83b7\u5956\u7ecf\u5386 1999 \u65e5\u672c\u5316\u5b66\u4f1a\u8fdb\u6b65\u5956 2007 \u764c\u75c7\u76ee\u6807\u6cbb\u7597\u5b66\u4f1a\u5956\u52b1\u5956 (Japanese Society for Neutron Capture Therapy) \u7814\u7a76\u4ecb\u7ecd 1. Development of new nanocarrier for boron neutron capture therapy [1,2] \u787c\u4e2d\u5b50\u4fd8\u83b7\u7597\u6cd5\uff08BNCT\uff09\u662f\u6307\u5bf9\u4eba\u4f53\u65e0\u5bb3\u7684\u4f4e\u70ed\u4e2d\u5b50\u88ab\u7ec6\u80de\u5185\u7684\u787c\u8bd5\u5242\u6355\u6349\u540e\uff0c10B\u8f6c\u53d8\u4e3a11B\u800c\u53d1\u751f\u88c2\u53d8\u4ea7\u751f\u9502\u548c\u03b1\u5c04\u7ebf\uff0c\u4ece\u800c\u901a\u8fc7\u03b1\u5c04\u7ebf\u7834\u574f\u764c\u7ec6\u80de\u7684\u65b0\u578b\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\u3002\u800cNakamura\u6559\u6388\u6b63\u81f4\u529b\u4e8e\u787c\u4e2d\u5b50\u6355\u83b7\u7597\u6cd5\u4e2d\u787c\u7eb3\u7c73\u8f7d\u4f53\u7684\u5f00\u53d1\u3002 Boron neutron capture therapy 2. Protein modification methods based on radical reaction [3] Nakamura\u6559\u6388\u5229\u7528\u81ea\u7531\u57fa\u7269\u79cd\u5bff\u547d\u77ed\u7684\u6027\u8d28\uff0c\u5f00\u53d1\u4e86\u4e00\u79cd\u901a\u8fc7\u5c40\u90e8\u4ea7\u751f\u81ea\u7531\u57fa\u6765\u9488\u5bf9\u5206\u5b50\u6c61\u67d3\u7269\u7684\u76ee\u6807\u9009\u62e9\u6027\u86cb\u767d\u8d28\u6807\u8bb0\u65b9\u6cd5\u3002\u7279\u522b\u5730\uff0c\u8be5\u65b9\u6cd5\u5728\u542b\u916a\u6c28\u9178\u6b8b\u57fa\u4f53\u7cfb\u4e2d\u6709\u5f88\u597d\u7684\u6548\u679c[3b,c]\u3002 Selective labeling of target protein by Ru photocatalyst 3. Drug discovery based bioactive substances with new skeleton [4] \u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u7684\u6838\u5fc3\u9aa8\u67b6\u5f00\u53d1\u662f\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u91cd\u8981\u4e00\u73af\uff0cNakamura\u6559\u6388\u6b63\u901a\u8fc7\u6709\u673a\u5408\u6210\u65b9\u6cd5\u6765\u5408\u6210\u65b0\u7684\u6846\u67b6\u7ed3\u6784\u7528\u4e8e\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u8bbe\u8ba1\uff0c\u5e76\u5bf9\u5176\u6d3b\u6027\u8fdb\u884c\u8bc4\u4f30\uff0c\u8fdb\u800c\u53cd\u9988\u81f3\u5206\u5b50\u6846\u67b6\u7ed3\u6784\u7684\u8bbe\u8ba1\u4e0e\u5408\u6210\u3002 Selected examples [&hellip;]","protected":false},"author":26,"featured_media":34046,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[212],"tags":[2941,2943,2942,2905],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/07\/F-17.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-8R4","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/34042"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=34042"}],"version-history":[{"count":1,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/34042\/revisions"}],"predecessor-version":[{"id":34047,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/34042\/revisions\/34047"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/34046"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=34042"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=34042"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=34042"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}