{"id":34324,"date":"2020-08-09T08:05:23","date_gmt":"2020-08-09T00:05:23","guid":{"rendered":"\/\/www.gsbet888.com\/?p=34324"},"modified":"2020-08-03T17:41:43","modified_gmt":"2020-08-03T09:41:43","slug":"%e8%a5%bf%e5%8c%97%e5%a4%a7%e5%ad%a6%e6%a0%be%e6%96%b0%e5%86%9b%e6%95%99%e6%8e%88%e8%af%be%e9%a2%98%e7%bb%84angew%ef%bc%9a%ce%b1-%ce%b2-%e4%b8%8d%e9%a5%b1%e5%92%8c%e4%ba%9a%e8%83%ba%e4%b8%8e%e6%ba%b4","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2020\/08\/%e8%a5%bf%e5%8c%97%e5%a4%a7%e5%ad%a6%e6%a0%be%e6%96%b0%e5%86%9b%e6%95%99%e6%8e%88%e8%af%be%e9%a2%98%e7%bb%84angew%ef%bc%9a%ce%b1-%ce%b2-%e4%b8%8d%e9%a5%b1%e5%92%8c%e4%ba%9a%e8%83%ba%e4%b8%8e%e6%ba%b4.html","title":{"rendered":"\u897f\u5317\u5927\u5b66\u683e\u65b0\u519b\u6559\u6388\u8bfe\u9898\u7ec4Angew\uff1a\u03b1, \u03b2-\u4e0d\u9971\u548c\u4e9a\u80fa\u4e0e\u6eb4\u915a\u7684[4+1]\u87ba\u73af\u5316\u53cd\u5e94\uff08\u53bb\u82b3\u5316\/\u8131\u6eb4\uff09"},"content":{"rendered":"

\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n

\u5bfc\u8bfb<\/h4>\n

\u8fd1\u65e5\uff0c\u897f\u5317\u5927\u5b66\u683e\u65b0\u519b\u6559\u6388\u8bfe\u9898\u7ec4\u5728\u5fb7\u56fd\u5e94\u5316\u6742\u5fd7\uff08Angewandte Chemie-International Edition\uff09\u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u5b9e\u73b0\u4e86\u90bb\uff08\u5bf9\uff09\u6eb4\u915a\u4e0e\u03b1<\/em>, \u03b2<\/em>-\u4e0d\u9971\u548c\u4e9a\u80fa\u7684[4+1]\u87ba\u73af\u5316\u53cd\u5e94\uff0c\u76f4\u63a5\u5408\u6210\u591a\u79cd\u65b0\u578b\u6c2e\u6742\u87ba\u73af\u5206\u5b50\u3002\u540c\u65f6\uff0c\u5176\u5b83\u51e0\u79cd\u5364\u4ee3\u915a\uff08X = Cl\uff0cI\uff09\u4e5f\u9002\u7528\u4e8e\u8be5\u8f6c\u5316\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u4f7f\u7528\u624b\u6027Sc(III)\/ Py-Box\u50ac\u5316\u5242\uff0c\u5b9e\u73b01-\u6eb4-2-\u8418\u915a\u7684\u4e0d\u5bf9\u79f0\u50ac\u5316\u53cd\u5e94\u3002\u53cd\u5e94\u673a\u7406\u7814\u7a76\u8868\u660e\uff0c\u8be5\u53cd\u5e94\u901a\u8fc7\u82ef\u915a\u884d\u751f\u7269\u7684\u53bb\u82b3\u5316\u4f5c\u7528\u540e\uff0c\u518d\u7ecf\u81ea\u7531\u57fa\u7684SRN<\/sub>1\u8fc7\u7a0b\u5b9e\u73b0\u5076\u8054\u3002<\/p>\n

A Dearomatization\/Debromination Strategy for the [4+1] Spiroannulation of Bromophenols with \u03b1<\/em>, \u03b2<\/em>-Unsaturated Imines<\/p>\n

Yicong Ge, Cheng Qin, Lu Bai, Jiamao Hao, Jingjing Liu,* and Xinjun Luan*<\/p>\n

Angew. Chem. Int. Ed<\/em>. ASAP DOI:10.1002\/anie.202008130<\/a><\/p><\/blockquote>\n

\"\"<\/a><\/p>\n

\u6b63\u6587<\/h4>\n

\u5364\u4ee3\u82ef\u915a\u4f5c\u4e3a\u6709\u673a\u5408\u6210\u4e2d\u901a\u7528\u4e14\u5e38\u89c1\u7684\u7ed3\u6784\u5355\u5143\u4e4b\u4e00\u3002\u636e\u6587\u732e\u67e5\u9605\uff0c\u5364\u4ee3\u915a\u5728\u5927\u591a\u6570\u5316\u5b66\u53cd\u5e94\u4e2d\u4e3b\u8981\u8131\u5364\u3001\u5076\u8054\u53cd\u5e94\u7b49\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u82ef\u915a\u7684\u53bb\u82b3\u5316\u5df2\u6210\u4e3a\u5408\u6210\u73af\u5df1\u4e8c\u916e\u7684\u6709\u6548\u624b\u6bb5\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u542b\u6709\u5364\u7d20\u6216\u785d\u57fa\u7684\u915a\u7f9f\u57fa\u4eb2\u7535\u4f53\uff0c\u51e0\u4e4e\u9650\u5236\u4e86\u5364\u4ee3\u82ef\u915a\u7684\u53bb\u82b3\u5316\u8fc7\u7a0b\uff08Scheme 1a\uff09\u3002\u540c\u65f6\uff0c\u4f7f\u7528\u78b3\u4eb2\u7535\u8bd5\u5242\u5f15\u53d1\u5364\u4ee3\u915a\u7684\u53bb\u82b3\u5316\u4f5c\u7528\u4ecd\u5177\u6311\u6218\u3002\u636e\u6587\u732e\u67e5\u9605\uff0cWang\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4e00\u4e2a\u6210\u529f\u7684\u4f8b\u5b50\uff0c\u8be5\u4f8b\u5b50\u8bc1\u660eMgII<\/sup>\u53ef\u5b9e\u73b01-\u6c1f-2-\u8418\u915a\u4e0e\u7094\u57faC(sp)-\u4eb2\u7535\u8bd5\u5242\u7684\u53bb\u82b3\u5316\u8fc7\u7a0b\uff08Scheme 1b\uff09\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u4f7f\u7528C-\u4eb2\u7535\u8bd5\u5242\uff0c\u5b9e\u73b0\u5364\u4ee3\u82ef\u915a\u53bb\u82b3\u5316\u8fc7\u7a0b\u5c1a\u672a\u88ab\u5b9e\u73b0\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u7ade\u4e89\u6027\u7684O<\/em>-\u70f7\u57fa\u5316\u6216\u4e0d\u7a33\u5b9a\u7684C(sp3<\/sup>)-X\uff08X = Cl\uff0cBr\uff0cI\uff09\u952e\u3002\u6b64\u5916\uff0c\u66fe\u6709\u8bfe\u9898\u7ec4\u63d0\u51fa\u5c06\u4e9a\u6c28\u57fa-\u8fc8\u514b\u5c14-\u70f7\u57fa\u5316-\u70ef\u80fa-\u8fc8\u514b\u5c14\u7ea7\u8054\u53cd\u5e94\u76f4\u63a5\u7528\u4e8e\u6eb4\u915a\u7684\u53bb\u82b3\u5316\u8fc7\u7a0b\uff0c\u8be5\u53cd\u5e94\u901a\u8fc7\u5c06\u5bcc\u7535\u5b50\u915a\u7c7b\u7684AlIII<\/sup>\u7edc\u5408\u7269\u4e0e\u4e59\u70ef\u57fa\u73af\u6c27\u5316\u5408\u7269\u8fdb\u884c\u53bb\u82b3\u5316\u4f5c\u7528\uff08Scheme 1c\uff09\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7684\u603b\u7ed3\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u4e00\u79cd\u65b0\u578b\u53bb\u82b3\u5316\/\u8131\u5364\u5316\u7684\u7b56\u7565\uff0c\u8be5\u53cd\u5e94\u662f\u901a\u8fc7\u5316\u5b66\u9009\u62e9\u6027\u7684\u8fc8\u514b\u5c14\u52a0\u6210\uff0c\u7528\u7f3a\u7535\u5b50\u7684\u5171\u8f6d\u70ef\u70c3\u5bf9\u5364\u4ee3\u82ef\u915a\u8fdb\u884c\u53bb\u82b3\u5316\uff0c\u7136\u540e\u901a\u8fc7\u539f\u4f4d\u5f62\u6210\u7684\u4eb2\u6838\u8bd5\u5242\u4fc3\u8fdb\u5206\u5b50\u5185\u8131\u5364\uff0c\u4ece\u800c\u5b9e\u73b0[[4+1]\u87ba\u73af\u5316\u53cd\u5e94\uff08Scheme 1d\uff09\u3002\u636e\u63a8\u6d4b\uff0c\u9664\u4e86\u5f15\u53d1\u53bb\u82b3\u5316\u7b2c\u4e00\u6b65\u7684\u72ec\u7279\u95ee\u9898\u5916\uff0c\u540c\u65f6\u4e5f\u9700\u786e\u5b9a\u5408\u9002\u7684\u4eb2\u6838\u8bd5\u5242\uff08Y\uff09\uff0c\u4ee5\u4ece\u9ad8\u80fd\u53bb\u82b3\u5316\u4e2d\u95f4\u4f53A<\/strong>\u53d6\u4ee3\u5364\u5316\u7269\u3002\u6839\u636e\u6587\u732e\u7684\u5148\u4f8b\uff0cA<\/strong>\u4e2d\u7684\u53d4\u70f7\u57fa\u5364\u5316\u7269\u6709\u4e24\u79cd\u53cd\u5e94\u65b9\u5f0f\uff1a\uff08i\uff09\u76f8\u5f53\u5c0f\u7684\u4eb2\u6838\u8bd5\u5242\uff08\u5982\u9187\u548c\u53e0\u6c2e\u5316\u7269\uff09\u53d6\u4ee3SN<\/sub>2\u578b\uff08path a\uff09\u3002\uff08ii\uff09\u901a\u8fc7\u4eb2\u6838\u6027SN<\/sub>2X\u6216\u57fa\u4e8e\u81ea\u7531\u57fa\u7684SRN<\/sub>1\u578b\uff0c\u8f83\u5927\u7684\u4eb2\u6838\u8bd5\u5242\u5bf9\u5364\u5316\u7269\u7684\u53cd\u5411\u653b\u51fb\uff08path b\uff09\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u9996\u5148\uff0c\u4f5c\u8005\u4ee51-\u6eb4-2-\u8418\u915a\uff081a<\/strong>\uff09\u4e0e\u5404\u79cd\u03b1<\/em>,\u03b2<\/em>-\u4e0d\u9971\u548c\u7fb0\u57fa\u884d\u751f\u7269\uff082<\/strong>\uff09\u4f5c\u4e3a\u5e95\u7269\uff0c\u5f00\u59cb\u5bf9\u53cd\u5e94\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u5f53\u4f7f\u7528\u03b1<\/em>,\u03b2<\/em>-\u4e0d\u9971\u548c\u4e9a\u80fa2a<\/strong>\u65f6\uff0c\u53ef\u5728\u975e\u5e38\u7b80\u5355\u7684\u65e0\u50ac\u5316\u6761\u4ef6\u4e0b\uff0c\u5b9e\u73b0\u9884\u671f\u7684[4+1]\u87ba\u73af\u5316\u53cd\u5e94\uff0c\u83b7\u5f9794\uff05\u6536\u7387\u7684\u4ea7\u72693a<\/strong>\uff08Scheme 2\uff09\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u968f\u540e\uff0c\u4f5c\u8005\u5bf9\u8be5\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u4e86\u7814\u7a76\uff08Table 1\uff09\u3002\u53cd\u5e94\u7ed3\u679c\u8868\u660e\uff0c\u5f53\u56fa\u5b9a1-\u6eb4-2-\u8418\u915a\u4f5c\u4e3a\u5e95\u7269\u65f6\uff0c\u53ef\u4e0e\u5404\u79cd\u03b1<\/em>, \u03b2<\/em>-\u4e0d\u9971\u548c\u4e9a\u80fa\uff082a<\/strong>–2m<\/strong>\uff09\u53cd\u5e94\uff0c\u83b7\u5f9758-94\uff05\u6536\u7387\u7684\u4ea7\u72693a<\/strong>–3m<\/strong>\u3002\u540c\u6837\uff0c\u5f53\u56fa\u5b9a\u03b1<\/em>, \u03b2<\/em>-\u4e0d\u9971\u548c\u4e9a\u80fa\u65f6\uff0c\u4e5f\u53ef\u4e0e\u5404\u79cd\u4e0d\u540c\u53d6\u4ee3\u76841-\u6eb4-2-\u8418\u915a\u53cd\u5e94\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u4ea7\u72693a’<\/strong>–3o’<\/strong>\u3002\u6b64\u5916\uff0c\u83f2\u915a\u3001\u55b9\u5549\u884d\u751f\u7269\u4e5f\u540c\u6837\u9002\u7528\u4e8e\u8be5\u4f53\u7cfb\uff0c\u83b7\u5f97\u4ea7\u72693p’<\/strong>–3r’<\/strong>\u3002\u5bf9\u4e8e\u90bb\u6eb4\u82ef\u915a\uff0c\u540c\u6837\u83b7\u5f97\u9884\u671f\u7684\u4ea7\u72693s’<\/strong>\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5f53\u4ee52,4-\u4e8c\u6eb4\u82ef\u915a4a<\/strong>\u4f5c\u4e3a\u5e95\u7269\u65f6\uff0c\u53cd\u5e94\u7684\u53bb\u82b3\u5316\u548c\u8131\u6eb4\u7684\u8fc7\u7a0b\u4ec5\u53d1\u751f\u57284a<\/strong>\u7684\u5bf9\u4f4d\uff0c\u5e76\u4ee590\uff05\u7684\u6536\u7387\u83b7\u5f97\u4ea7\u72695a<\/strong>\uff0c\u540c\u65f6\uff0c\u5e76\u672a\u89c2\u5bdf\u5230\u90bb\u4f4d\u53bb\u82b3\u5316\u7684\u8fc7\u7a0b\uff08Scheme 3\uff09\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u7d27\u63a5\u7740\uff0c\u4f5c\u8005\u4ee5\u5bf9\u6eb4\u82ef\u915a\u4f5c\u4e3a\u5e95\u7269\uff0c\u5bf9\u53cd\u5e94\u8fdb\u884c\u4e86\u7814\u7a76\uff08Table 2\uff09\u3002\u53cd\u5e94\u7ed3\u679c\u8868\u660e\uff0c\u542b\u6709\u6c2f\uff084b<\/strong>\uff09\u3001\u7532\u57fa\uff084c<\/strong>\uff09\u3001\u6b63\u4e19\u57fa\uff084d<\/strong>\uff09\u3001\u53d4\u4e01\u57fa\uff084e<\/strong>\uff09\uff0c\u5747\u53ef\u987a\u5229\u53cd\u5e94\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u4ea7\u72695a<\/strong>–5e<\/strong>\u3002\u7136\u800c\uff0c\u4f7f\u7528\u7f3a\u5c11\u90bb\u4f4d\u53d6\u4ee3\u57fa\u76844-\u6eb4\u82ef\u915a4f<\/strong>\u65f6\uff0c\u53cd\u5e94\u901a\u8fc7\u5b8c\u5168\u4e0d\u540c\u7684\u70f7\u57fa\u5316\/\u916f\u5316\u9014\u5f84\u8fdb\u884c\uff0c\u4ece\u800c\u83b7\u5f97\u4ea7\u72695f’<\/strong>\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u4e5f\u53d1\u73b0\u915a\u73af\uff084g<\/strong>–4h<\/strong>\uff09\u7684\u53e6\u5916\u4e24\u4e2a\u53d6\u4ee3\u6a21\u5f0f\uff08\u901a\u8fc74c<\/strong>\u4e2d\u7684\u7532\u57fa\u8f6c\u4f4d\u6765\u8bf4\u660e\uff09\u3002\u901a\u8fc7\u5c06\u4e00\u4e2a\u7532\u57fa\u8f6c\u79fb\u5230\u76f8\u90bb\u7684\u95f4\u4f4d\uff0c\u4e0e4g<\/strong>\u53cd\u5e94\u53ef\u6709\u6548\u8fdb\u884c\uff0c\u83b7\u5f9793\uff05\u7684\u6536\u7387\u76845g<\/strong>\u3002\u901a\u8fc7\u5c06\u4e00\u4e2a\u7532\u57fa\u8f6c\u79fb\u5230\u76f8\u53cd\u7684\u95f4\u4f4d\uff084h<\/strong>\uff09\uff0c\u53ef\u4ee5\u53d1\u751f[4+1]\u87ba\u73af\u5316\u53cd\u5e94\uff0c\u4ee572\uff05\u7684\u6536\u7387\u83b7\u5f975h<\/strong>\u3002\u4f46\u8be5\u53cd\u5e94\u5bf9\u4e8e\u8f83\u5c11\u4eb2\u6838\u6027\u76844-\u6eb4\u8418-1-\u9187\u5e76\u4e0d\u9002\u7528\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5f00\u59cb\u5bf9\u5176\u4ed6\u5364\u4ee3\u915a\uff08X = Cl\uff0cI\uff09\u8fdb\u884c\u4e86\u7814\u7a76\uff08Scheme 4\uff09\u3002\u53cd\u5e94\u7ed3\u679c\u8868\u660e\uff0c\u6c2f\u548c\u7898\u4ee3\u5e95\u7269\uff081aI<\/sup><\/strong>\uff0c1aII<\/sup><\/strong>\uff0c4cI<\/sup><\/strong>\uff0c4cII<\/sup><\/strong>\uff09\u5747\u53ef\u987a\u5229\u53cd\u5e94\uff0c\u901a\u5e38\uff0c\u6c2f\u4ee3\u5e95\u7269\u6536\u7387\u9ad8\uff0c\u800c\u7898\u4ee3\u5e95\u7269\u6536\u7387\u504f\u4f4e\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e3a\u4e86\u8fdb\u4e00\u6b65\u8bc1\u660e\u7528\u53cd\u5e94\u7684\u5b9e\u7528\u6027\uff0c\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u4e0d\u5bf9\u79f0\u53cd\u5e94\uff08Table 3\uff09\u3002\u901a\u8fc7\u5927\u91cf\u6761\u4ef6\u7684\u7b5b\u9009\uff0c\u4f5c\u8005\u53d1\u5f53\u4ee5\u624b\u6027Sc(III)\/Py-Box\u50ac\u5316\u5242\u65f6\uff0c\u80fd\u591f\u4fc3\u8fdb1-\u6eb4-2-\u8418\u915a\uff081<\/strong>\uff09\u4e0e\u03b1<\/em>, \u03b2<\/em>-\u4e0d\u9971\u548c\u4e9a\u80fa\uff082<\/strong>\uff09\u7684\u4e0d\u5bf9\u79f0[4+1]\u87ba\u73af\u5316\u53cd\u5e94\uff0c\u5e76\u4ee5\u9ad8\u4ea7\u7387\uff0855-94\uff05\uff09\u548c\u4f18\u5f02\u7684\u5bf9\u6620\u9009\u62e9\u6027\uff0890-99\uff05ee\uff09\u83b7\u5f97\u591a\u79cd\u624b\u6027\u87ba\u73af\u4ea7\u72693a<\/strong>\u201d<\/strong>–3t<\/strong>\u201d<\/strong>\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8418\u73af\u76846\u30017\u4f4d\u4e0a\u7684\u53d8\u5316\u4fdd\u6301\u4e86\u9ad8\u6c34\u5e73\u7684\u5bf9\u6620\u9009\u62e9\u6027\uff08\u5728\u6240\u6709\u60c5\u51b5\u4e0b\uff0cee\u5747> 96\uff05\uff09\uff0c\u4f46\u57283\u4f4d\u53d6\u4ee3\u5bfc\u81f4\u7ed3\u679c\u76f8\u5f53\u5dee\uff083f”<\/strong>\uff09\uff0c\u53ef\u80fd\u7531\u4e8e\u589e\u52a0\u7684\u7a7a\u95f4\u4f4d\u963b\u76f4\u63a5\u4e2d\u65ad\u4e86\u7f9f\u57fa\u4e0eSc(III)-\u4e2d\u5fc3\u4e4b\u95f4\u7684\u5fc5\u8981\u7ed3\u5408\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u57fa\u4e8e\u4e0a\u8ff0\u7684\u8ba8\u8bba\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u5408\u7406\u53cd\u5e94\u673a\u7406\uff08Scheme 5\uff09\u3002\u9996\u5148\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u7ecf\u8fc8\u514b\u5c14\u52a0\u6210\u53cd\u5e94\u5f62\u6210\u53bb\u82b3\u5316\u7684\u4e2d\u95f4\u4f53A<\/strong>\u3002\u5f53\u4ee5\u53bb\u82b3\u53166\u4f5c\u4e3a\u5e95\u7269\u65f6\uff0c\u4e5f\u53ef\u5b9e\u73b0\u87ba\u73af\u5316\u53cd\u5e94\uff08Scheme 5b\uff09\u3002\u800c\u5bf9\u4e8e\u8131\u6eb4\u6b65\u9aa4\uff0c\u53ef\u80fd\u6d89\u53caSN<\/sub>2X\u6216SRN<\/sub>1\u673a\u7406\uff08Scheme 5c\uff09\u3002\u901a\u8fc78<\/strong>\u548c9<\/strong>\u53cd\u5e94\u7684\u7ed3\u679c\u8868\u660e\uff0c\u53bb\u82b3\u5316\u76848<\/strong>\u5145\u5f539<\/strong>\u4e2d\u78fa\u9170\u80fa\u9634\u79bb\u5b50\u7684\u5355\u7535\u5b50\u6c27\u5316\u5242\uff0c\u4ea7\u751f\u6c2e\u81ea\u7531\u57faI<\/strong>\u548c\u78b3\u81ea\u7531\u57faII<\/strong>\uff08SRN<\/sub>1 path\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cII<\/strong>\u81ea\u7531\u57fa\u8f6c\u79fb\u5f62\u6210\u4f53\u79ef\u8f83\u5c0f\u7684\u6c27\u81ea\u7531\u57faII<\/strong>\u201d<\/strong>\uff0c\u53ef\u4e0e\u81ea\u7531\u57faII<\/strong>\u53d1\u751f\u5076\u8054\uff0c\u5f62\u621011<\/strong>\u3002\u6b64\u5916\uff0c8<\/strong>\u4e0e1-\u4e59\u57fa-2-\u8418\u915a\uff0812<\/strong>\uff09\u7684\u53cd\u5e94\u7ed3\u679c\u6392\u9664\u4e86\u6709\u4e89\u8bae\u7684SN<\/sub>2X\u9014\u5f84\uff0c\u56e0\u4e3a\u901a\u8fc7\u5355\u7535\u5b50\u8f6c\u79fbSRN<\/sub>1\u9014\u5f84\u539f\u4f4d\u751f\u6210\u56db\u4e2a\u53ef\u80fd\u7684\u81ea\u7531\u57faII<\/strong>\uff0cII’<\/strong>\uff0cIIEt<\/sub><\/strong>\u548cII’Et<\/sub><\/strong>\uff0c\u53ef\u53d1\u751f\u4ea4\u53c9\u5076\u8054\u5f62\u6210\u56db\u79cd\u4ea7\u726911<\/strong>\u548c13<\/strong>–15<\/strong>\u7684\u6df7\u5408\u7269\uff08Scheme 5d\uff09\u3002\u6b64\u5916\uff0c\u6c2e\u81ea\u7531\u57faI<\/strong>\u53ef\u4ee5\u88abBHT\u6355\u83b7\uff08Scheme 5e\uff09\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u8ba4\u4e3a\u8be5[4+1]\u87ba\u73af\u53cd\u5e94\u7684\u8131\u6eb4\u6b65\u9aa4\u9075\u5faa\u57fa\u4e8e\u81ea\u7531\u57fa\u7684SRN<\/sub>1\u673a\u5236\uff08Scheme 5f\uff09\u3002<\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\u603b\u7ed3<\/h4>\n

\u897f\u5317\u5927\u5b66\u683e\u65b0\u519b\u6559\u6388\u8bfe\u9898\u7ec4\u901a\u8fc7\u53bb\u82b3\u5316\/\u8131\u5364\u7b56\u7565\uff0c\u5b9e\u73b0\u4e86\u90bb\uff08\u5bf9\uff09\u6eb4\u915a\u4e0e\u03b1<\/em>, \u03b2<\/em>-\u4e0d\u9971\u548c\u4e9a\u80fa\u7684[4+1]\u87ba\u73af\u5316\u53cd\u5e94\uff0c\u76f4\u63a5\u5408\u6210\u591a\u79cd\u65b0\u578b\u6c2e\u6742\u87ba\u73af\u5206\u5b50\u3002\u540c\u65f6\uff0c\u5176\u5b83\u51e0\u79cd\u5364\u4ee3\u915a\uff08X = Cl\uff0cI\uff09\u4e5f\u9002\u7528\u4e8e\u8be5\u8f6c\u5316\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u4f7f\u7528\u624b\u6027Sc(III)\/ Py-Box\u50ac\u5316\u5242\uff0c\u5b9e\u73b01-\u6eb4-2-\u8418\u915a\u7684\u4e0d\u5bf9\u79f0\u50ac\u5316\u53cd\u5e94\u3002\u53cd\u5e94\u673a\u7406\u7814\u7a76\u8868\u660e\uff0c\u8be5\u53cd\u5e94\u901a\u8fc7\u82ef\u915a\u884d\u751f\u7269\u7684\u53bb\u82b3\u5316\u4f5c\u7528\u540e\uff0c\u518d\u7ecf\u81ea\u7531\u57fa\u7684SRN<\/sub>1\u8fc7\u7a0b\u5b9e\u73b0\u5076\u8054\u3002<\/p>\n

\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb \u8fd1\u65e5\uff0c\u897f\u5317\u5927\u5b66\u683e\u65b0\u519b\u6559\u6388\u8bfe\u9898\u7ec4\u5728\u5fb7\u56fd\u5e94\u5316\u6742\u5fd7\uff08Angewandte Chemie-International Edition\uff09\u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u5b9e\u73b0\u4e86\u90bb\uff08\u5bf9\uff09\u6eb4\u915a\u4e0e\u03b1, \u03b2-\u4e0d\u9971\u548c\u4e9a\u80fa\u7684[4+1]\u87ba\u73af\u5316\u53cd\u5e94\uff0c\u76f4\u63a5\u5408\u6210\u591a\u79cd\u65b0\u578b\u6c2e\u6742\u87ba\u73af\u5206\u5b50\u3002\u540c\u65f6\uff0c\u5176\u5b83\u51e0\u79cd\u5364\u4ee3\u915a\uff08X = Cl\uff0cI\uff09\u4e5f\u9002\u7528\u4e8e\u8be5\u8f6c\u5316\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u4f7f\u7528\u624b\u6027Sc(III)\/ Py-Box\u50ac\u5316\u5242\uff0c\u5b9e\u73b01-\u6eb4-2-\u8418\u915a\u7684\u4e0d\u5bf9\u79f0\u50ac\u5316\u53cd\u5e94\u3002\u53cd\u5e94\u673a\u7406\u7814\u7a76\u8868\u660e\uff0c\u8be5\u53cd\u5e94\u901a\u8fc7\u82ef\u915a\u884d\u751f\u7269\u7684\u53bb\u82b3\u5316\u4f5c\u7528\u540e\uff0c\u518d\u7ecf\u81ea\u7531\u57fa\u7684SRN1\u8fc7\u7a0b\u5b9e\u73b0\u5076\u8054\u3002 A Dearomatization\/Debromination Strategy for the [4+1] Spiroannulation of Bromophenols with \u03b1, \u03b2-Unsaturated Imines Yicong Ge, Cheng Qin, Lu Bai, Jiamao Hao, Jingjing Liu,* and Xinjun Luan* Angew. Chem. Int. Ed. ASAP DOI:10.1002\/anie.202008130 \u6b63\u6587 \u5364\u4ee3\u82ef\u915a\u4f5c\u4e3a\u6709\u673a\u5408\u6210\u4e2d\u901a\u7528\u4e14\u5e38\u89c1\u7684\u7ed3\u6784\u5355\u5143\u4e4b\u4e00\u3002\u636e\u6587\u732e\u67e5\u9605\uff0c\u5364\u4ee3\u915a\u5728\u5927\u591a\u6570\u5316\u5b66\u53cd\u5e94\u4e2d\u4e3b\u8981\u8131\u5364\u3001\u5076\u8054\u53cd\u5e94\u7b49\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u82ef\u915a\u7684\u53bb\u82b3\u5316\u5df2\u6210\u4e3a\u5408\u6210\u73af\u5df1\u4e8c\u916e\u7684\u6709\u6548\u624b\u6bb5\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u542b\u6709\u5364\u7d20\u6216\u785d\u57fa\u7684\u915a\u7f9f\u57fa\u4eb2\u7535\u4f53\uff0c\u51e0\u4e4e\u9650\u5236\u4e86\u5364\u4ee3\u82ef\u915a\u7684\u53bb\u82b3\u5316\u8fc7\u7a0b\uff08Scheme 1a\uff09\u3002\u540c\u65f6\uff0c\u4f7f\u7528\u78b3\u4eb2\u7535\u8bd5\u5242\u5f15\u53d1\u5364\u4ee3\u915a\u7684\u53bb\u82b3\u5316\u4f5c\u7528\u4ecd\u5177\u6311\u6218\u3002\u636e\u6587\u732e\u67e5\u9605\uff0cWang\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4e00\u4e2a\u6210\u529f\u7684\u4f8b\u5b50\uff0c\u8be5\u4f8b\u5b50\u8bc1\u660eMgII\u53ef\u5b9e\u73b01-\u6c1f-2-\u8418\u915a\u4e0e\u7094\u57faC(sp)-\u4eb2\u7535\u8bd5\u5242\u7684\u53bb\u82b3\u5316\u8fc7\u7a0b\uff08Scheme 1b\uff09\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u4f7f\u7528C-\u4eb2\u7535\u8bd5\u5242\uff0c\u5b9e\u73b0\u5364\u4ee3\u82ef\u915a\u53bb\u82b3\u5316\u8fc7\u7a0b\u5c1a\u672a\u88ab\u5b9e\u73b0\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u7ade\u4e89\u6027\u7684O-\u70f7\u57fa\u5316\u6216\u4e0d\u7a33\u5b9a\u7684C(sp3)-X\uff08X = Cl\uff0cBr\uff0cI\uff09\u952e\u3002\u6b64\u5916\uff0c\u66fe\u6709\u8bfe\u9898\u7ec4\u63d0\u51fa\u5c06\u4e9a\u6c28\u57fa-\u8fc8\u514b\u5c14-\u70f7\u57fa\u5316-\u70ef\u80fa-\u8fc8\u514b\u5c14\u7ea7\u8054\u53cd\u5e94\u76f4\u63a5\u7528\u4e8e\u6eb4\u915a\u7684\u53bb\u82b3\u5316\u8fc7\u7a0b\uff0c\u8be5\u53cd\u5e94\u901a\u8fc7\u5c06\u5bcc\u7535\u5b50\u915a\u7c7b\u7684AlIII\u7edc\u5408\u7269\u4e0e\u4e59\u70ef\u57fa\u73af\u6c27\u5316\u5408\u7269\u8fdb\u884c\u53bb\u82b3\u5316\u4f5c\u7528\uff08Scheme 1c\uff09\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7684\u603b\u7ed3\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u4e00\u79cd\u65b0\u578b\u53bb\u82b3\u5316\/\u8131\u5364\u5316\u7684\u7b56\u7565\uff0c\u8be5\u53cd\u5e94\u662f\u901a\u8fc7\u5316\u5b66\u9009\u62e9\u6027\u7684\u8fc8\u514b\u5c14\u52a0\u6210\uff0c\u7528\u7f3a\u7535\u5b50\u7684\u5171\u8f6d\u70ef\u70c3\u5bf9\u5364\u4ee3\u82ef\u915a\u8fdb\u884c\u53bb\u82b3\u5316\uff0c\u7136\u540e\u901a\u8fc7\u539f\u4f4d\u5f62\u6210\u7684\u4eb2\u6838\u8bd5\u5242\u4fc3\u8fdb\u5206\u5b50\u5185\u8131\u5364\uff0c\u4ece\u800c\u5b9e\u73b0[[4+1]\u87ba\u73af\u5316\u53cd\u5e94\uff08Scheme 1d\uff09\u3002\u636e\u63a8\u6d4b\uff0c\u9664\u4e86\u5f15\u53d1\u53bb\u82b3\u5316\u7b2c\u4e00\u6b65\u7684\u72ec\u7279\u95ee\u9898\u5916\uff0c\u540c\u65f6\u4e5f\u9700\u786e\u5b9a\u5408\u9002\u7684\u4eb2\u6838\u8bd5\u5242\uff08Y\uff09\uff0c\u4ee5\u4ece\u9ad8\u80fd\u53bb\u82b3\u5316\u4e2d\u95f4\u4f53A\u53d6\u4ee3\u5364\u5316\u7269\u3002\u6839\u636e\u6587\u732e\u7684\u5148\u4f8b\uff0cA\u4e2d\u7684\u53d4\u70f7\u57fa\u5364\u5316\u7269\u6709\u4e24\u79cd\u53cd\u5e94\u65b9\u5f0f\uff1a\uff08i\uff09\u76f8\u5f53\u5c0f\u7684\u4eb2\u6838\u8bd5\u5242\uff08\u5982\u9187\u548c\u53e0\u6c2e\u5316\u7269\uff09\u53d6\u4ee3SN2\u578b\uff08path a\uff09\u3002\uff08ii\uff09\u901a\u8fc7\u4eb2\u6838\u6027SN2X\u6216\u57fa\u4e8e\u81ea\u7531\u57fa\u7684SRN1\u578b\uff0c\u8f83\u5927\u7684\u4eb2\u6838\u8bd5\u5242\u5bf9\u5364\u5316\u7269\u7684\u53cd\u5411\u653b\u51fb\uff08path b\uff09\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u4ee51-\u6eb4-2-\u8418\u915a\uff081a\uff09\u4e0e\u5404\u79cd\u03b1,\u03b2-\u4e0d\u9971\u548c\u7fb0\u57fa\u884d\u751f\u7269\uff082\uff09\u4f5c\u4e3a\u5e95\u7269\uff0c\u5f00\u59cb\u5bf9\u53cd\u5e94\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u5f53\u4f7f\u7528\u03b1,\u03b2-\u4e0d\u9971\u548c\u4e9a\u80fa2a\u65f6\uff0c\u53ef\u5728\u975e\u5e38\u7b80\u5355\u7684\u65e0\u50ac\u5316\u6761\u4ef6\u4e0b\uff0c\u5b9e\u73b0\u9884\u671f\u7684[4+1]\u87ba\u73af\u5316\u53cd\u5e94\uff0c\u83b7\u5f9794\uff05\u6536\u7387\u7684\u4ea7\u72693a\uff08Scheme 2\uff09\u3002 \u968f\u540e\uff0c\u4f5c\u8005\u5bf9\u8be5\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u4e86\u7814\u7a76\uff08Table 1\uff09\u3002\u53cd\u5e94\u7ed3\u679c\u8868\u660e\uff0c\u5f53\u56fa\u5b9a1-\u6eb4-2-\u8418\u915a\u4f5c\u4e3a\u5e95\u7269\u65f6\uff0c\u53ef\u4e0e\u5404\u79cd\u03b1, \u03b2-\u4e0d\u9971\u548c\u4e9a\u80fa\uff082a–2m\uff09\u53cd\u5e94\uff0c\u83b7\u5f9758-94\uff05\u6536\u7387\u7684\u4ea7\u72693a–3m\u3002\u540c\u6837\uff0c\u5f53\u56fa\u5b9a\u03b1, \u03b2-\u4e0d\u9971\u548c\u4e9a\u80fa\u65f6\uff0c\u4e5f\u53ef\u4e0e\u5404\u79cd\u4e0d\u540c\u53d6\u4ee3\u76841-\u6eb4-2-\u8418\u915a\u53cd\u5e94\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u4ea7\u72693a’–3o’\u3002\u6b64\u5916\uff0c\u83f2\u915a\u3001\u55b9\u5549\u884d\u751f\u7269\u4e5f\u540c\u6837\u9002\u7528\u4e8e\u8be5\u4f53\u7cfb\uff0c\u83b7\u5f97\u4ea7\u72693p’–3r’\u3002\u5bf9\u4e8e\u90bb\u6eb4\u82ef\u915a\uff0c\u540c\u6837\u83b7\u5f97\u9884\u671f\u7684\u4ea7\u72693s’\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5f53\u4ee52,4-\u4e8c\u6eb4\u82ef\u915a4a\u4f5c\u4e3a\u5e95\u7269\u65f6\uff0c\u53cd\u5e94\u7684\u53bb\u82b3\u5316\u548c\u8131\u6eb4\u7684\u8fc7\u7a0b\u4ec5\u53d1\u751f\u57284a\u7684\u5bf9\u4f4d\uff0c\u5e76\u4ee590\uff05\u7684\u6536\u7387\u83b7\u5f97\u4ea7\u72695a\uff0c\u540c\u65f6\uff0c\u5e76\u672a\u89c2\u5bdf\u5230\u90bb\u4f4d\u53bb\u82b3\u5316\u7684\u8fc7\u7a0b\uff08Scheme 3\uff09\u3002 \u7d27\u63a5\u7740\uff0c\u4f5c\u8005\u4ee5\u5bf9\u6eb4\u82ef\u915a\u4f5c\u4e3a\u5e95\u7269\uff0c\u5bf9\u53cd\u5e94\u8fdb\u884c\u4e86\u7814\u7a76\uff08Table 2\uff09\u3002\u53cd\u5e94\u7ed3\u679c\u8868\u660e\uff0c\u542b\u6709\u6c2f\uff084b\uff09\u3001\u7532\u57fa\uff084c\uff09\u3001\u6b63\u4e19\u57fa\uff084d\uff09\u3001\u53d4\u4e01\u57fa\uff084e\uff09\uff0c\u5747\u53ef\u987a\u5229\u53cd\u5e94\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u4ea7\u72695a–5e\u3002\u7136\u800c\uff0c\u4f7f\u7528\u7f3a\u5c11\u90bb\u4f4d\u53d6\u4ee3\u57fa\u76844-\u6eb4\u82ef\u915a4f\u65f6\uff0c\u53cd\u5e94\u901a\u8fc7\u5b8c\u5168\u4e0d\u540c\u7684\u70f7\u57fa\u5316\/\u916f\u5316\u9014\u5f84\u8fdb\u884c\uff0c\u4ece\u800c\u83b7\u5f97\u4ea7\u72695f’\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u4e5f\u53d1\u73b0\u915a\u73af\uff084g–4h\uff09\u7684\u53e6\u5916\u4e24\u4e2a\u53d6\u4ee3\u6a21\u5f0f\uff08\u901a\u8fc74c\u4e2d\u7684\u7532\u57fa\u8f6c\u4f4d\u6765\u8bf4\u660e\uff09\u3002\u901a\u8fc7\u5c06\u4e00\u4e2a\u7532\u57fa\u8f6c\u79fb\u5230\u76f8\u90bb\u7684\u95f4\u4f4d\uff0c\u4e0e4g\u53cd\u5e94\u53ef\u6709\u6548\u8fdb\u884c\uff0c\u83b7\u5f9793\uff05\u7684\u6536\u7387\u76845g\u3002\u901a\u8fc7\u5c06\u4e00\u4e2a\u7532\u57fa\u8f6c\u79fb\u5230\u76f8\u53cd\u7684\u95f4\u4f4d\uff084h\uff09\uff0c\u53ef\u4ee5\u53d1\u751f[4+1]\u87ba\u73af\u5316\u53cd\u5e94\uff0c\u4ee572\uff05\u7684\u6536\u7387\u83b7\u5f975h\u3002\u4f46\u8be5\u53cd\u5e94\u5bf9\u4e8e\u8f83\u5c11\u4eb2\u6838\u6027\u76844-\u6eb4\u8418-1-\u9187\u5e76\u4e0d\u9002\u7528\u3002 \u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5f00\u59cb\u5bf9\u5176\u4ed6\u5364\u4ee3\u915a\uff08X = Cl\uff0cI\uff09\u8fdb\u884c\u4e86\u7814\u7a76\uff08Scheme 4\uff09\u3002\u53cd\u5e94\u7ed3\u679c\u8868\u660e\uff0c\u6c2f\u548c\u7898\u4ee3\u5e95\u7269\uff081aI\uff0c1aII\uff0c4cI\uff0c4cII\uff09\u5747\u53ef\u987a\u5229\u53cd\u5e94\uff0c\u901a\u5e38\uff0c\u6c2f\u4ee3\u5e95\u7269\u6536\u7387\u9ad8\uff0c\u800c\u7898\u4ee3\u5e95\u7269\u6536\u7387\u504f\u4f4e\u3002 \u4e3a\u4e86\u8fdb\u4e00\u6b65\u8bc1\u660e\u7528\u53cd\u5e94\u7684\u5b9e\u7528\u6027\uff0c\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u4e0d\u5bf9\u79f0\u53cd\u5e94\uff08Table 3\uff09\u3002\u901a\u8fc7\u5927\u91cf\u6761\u4ef6\u7684\u7b5b\u9009\uff0c\u4f5c\u8005\u53d1\u5f53\u4ee5\u624b\u6027Sc(III)\/Py-Box\u50ac\u5316\u5242\u65f6\uff0c\u80fd\u591f\u4fc3\u8fdb1-\u6eb4-2-\u8418\u915a\uff081\uff09\u4e0e\u03b1, \u03b2-\u4e0d\u9971\u548c\u4e9a\u80fa\uff082\uff09\u7684\u4e0d\u5bf9\u79f0[4+1]\u87ba\u73af\u5316\u53cd\u5e94\uff0c\u5e76\u4ee5\u9ad8\u4ea7\u7387\uff0855-94\uff05\uff09\u548c\u4f18\u5f02\u7684\u5bf9\u6620\u9009\u62e9\u6027\uff0890-99\uff05ee\uff09\u83b7\u5f97\u591a\u79cd\u624b\u6027\u87ba\u73af\u4ea7\u72693a\u201d–3t\u201d\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8418\u73af\u76846\u30017\u4f4d\u4e0a\u7684\u53d8\u5316\u4fdd\u6301\u4e86\u9ad8\u6c34\u5e73\u7684\u5bf9\u6620\u9009\u62e9\u6027\uff08\u5728\u6240\u6709\u60c5\u51b5\u4e0b\uff0cee\u5747> 96\uff05\uff09\uff0c\u4f46\u57283\u4f4d\u53d6\u4ee3\u5bfc\u81f4\u7ed3\u679c\u76f8\u5f53\u5dee\uff083f”\uff09\uff0c\u53ef\u80fd\u7531\u4e8e\u589e\u52a0\u7684\u7a7a\u95f4\u4f4d\u963b\u76f4\u63a5\u4e2d\u65ad\u4e86\u7f9f\u57fa\u4e0eSc(III)-\u4e2d\u5fc3\u4e4b\u95f4\u7684\u5fc5\u8981\u7ed3\u5408\u3002 \u57fa\u4e8e\u4e0a\u8ff0\u7684\u8ba8\u8bba\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u5408\u7406\u53cd\u5e94\u673a\u7406\uff08Scheme 5\uff09\u3002\u9996\u5148\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u7ecf\u8fc8\u514b\u5c14\u52a0\u6210\u53cd\u5e94\u5f62\u6210\u53bb\u82b3\u5316\u7684\u4e2d\u95f4\u4f53A\u3002\u5f53\u4ee5\u53bb\u82b3\u53166\u4f5c\u4e3a\u5e95\u7269\u65f6\uff0c\u4e5f\u53ef\u5b9e\u73b0\u87ba\u73af\u5316\u53cd\u5e94\uff08Scheme 5b\uff09\u3002\u800c\u5bf9\u4e8e\u8131\u6eb4\u6b65\u9aa4\uff0c\u53ef\u80fd\u6d89\u53caSN2X\u6216SRN1\u673a\u7406\uff08Scheme 5c\uff09\u3002\u901a\u8fc78\u548c9\u53cd\u5e94\u7684\u7ed3\u679c\u8868\u660e\uff0c\u53bb\u82b3\u5316\u76848\u5145\u5f539\u4e2d\u78fa\u9170\u80fa\u9634\u79bb\u5b50\u7684\u5355\u7535\u5b50\u6c27\u5316\u5242\uff0c\u4ea7\u751f\u6c2e\u81ea\u7531\u57faI\u548c\u78b3\u81ea\u7531\u57faII\uff08SRN1 path\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cII\u81ea\u7531\u57fa\u8f6c\u79fb\u5f62\u6210\u4f53\u79ef\u8f83\u5c0f\u7684\u6c27\u81ea\u7531\u57faII\u201d\uff0c\u53ef\u4e0e\u81ea\u7531\u57faII\u53d1\u751f\u5076\u8054\uff0c\u5f62\u621011\u3002\u6b64\u5916\uff0c8\u4e0e1-\u4e59\u57fa-2-\u8418\u915a\uff0812\uff09\u7684\u53cd\u5e94\u7ed3\u679c\u6392\u9664\u4e86\u6709\u4e89\u8bae\u7684SN2X\u9014\u5f84\uff0c\u56e0\u4e3a\u901a\u8fc7\u5355\u7535\u5b50\u8f6c\u79fbSRN1\u9014\u5f84\u539f\u4f4d\u751f\u6210\u56db\u4e2a\u53ef\u80fd\u7684\u81ea\u7531\u57faII\uff0cII’\uff0cIIEt\u548cII’Et\uff0c\u53ef\u53d1\u751f\u4ea4\u53c9\u5076\u8054\u5f62\u6210\u56db\u79cd\u4ea7\u726911\u548c13–15\u7684\u6df7\u5408\u7269\uff08Scheme 5d\uff09\u3002\u6b64\u5916\uff0c\u6c2e\u81ea\u7531\u57faI\u53ef\u4ee5\u88abBHT\u6355\u83b7\uff08Scheme 5e\uff09\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u8ba4\u4e3a\u8be5[4+1]\u87ba\u73af\u53cd\u5e94\u7684\u8131\u6eb4\u6b65\u9aa4\u9075\u5faa\u57fa\u4e8e\u81ea\u7531\u57fa\u7684SRN1\u673a\u5236\uff08Scheme 5f\uff09\u3002 \u603b\u7ed3 \u897f\u5317\u5927\u5b66\u683e\u65b0\u519b\u6559\u6388\u8bfe\u9898\u7ec4\u901a\u8fc7\u53bb\u82b3\u5316\/\u8131\u5364\u7b56\u7565\uff0c\u5b9e\u73b0\u4e86\u90bb\uff08\u5bf9\uff09\u6eb4\u915a\u4e0e\u03b1, \u03b2-\u4e0d\u9971\u548c\u4e9a\u80fa\u7684[4+1]\u87ba\u73af\u5316\u53cd\u5e94\uff0c\u76f4\u63a5\u5408\u6210\u591a\u79cd\u65b0\u578b\u6c2e\u6742\u87ba\u73af\u5206\u5b50\u3002\u540c\u65f6\uff0c\u5176\u5b83\u51e0\u79cd\u5364\u4ee3\u915a\uff08X = Cl\uff0cI\uff09\u4e5f\u9002\u7528\u4e8e\u8be5\u8f6c\u5316\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u4f7f\u7528\u624b\u6027Sc(III)\/ Py-Box\u50ac\u5316\u5242\uff0c\u5b9e\u73b01-\u6eb4-2-\u8418\u915a\u7684\u4e0d\u5bf9\u79f0\u50ac\u5316\u53cd\u5e94\u3002\u53cd\u5e94\u673a\u7406\u7814\u7a76\u8868\u660e\uff0c\u8be5\u53cd\u5e94\u901a\u8fc7\u82ef\u915a\u884d\u751f\u7269\u7684\u53bb\u82b3\u5316\u4f5c\u7528\u540e\uff0c\u518d\u7ecf\u81ea\u7531\u57fa\u7684SRN1\u8fc7\u7a0b\u5b9e\u73b0\u5076\u8054\u3002 \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01","protected":false},"author":26,"featured_media":34335,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1271],"tags":[2987,488,2985,2984,2986],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/F-16.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-8VC","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/34324"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=34324"}],"version-history":[{"count":1,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/34324\/revisions"}],"predecessor-version":[{"id":34336,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/34324\/revisions\/34336"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/34335"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=34324"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=34324"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=34324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}