{"id":34603,"date":"2020-08-26T08:00:57","date_gmt":"2020-08-26T00:00:57","guid":{"rendered":"\/\/www.gsbet888.com\/?p=34603"},"modified":"2020-08-23T15:43:08","modified_gmt":"2020-08-23T07:43:08","slug":"scott-a-snyder","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/2020\/08\/scott-a-snyder.html","title":{"rendered":"Scott A. Snyder"},"content":{"rendered":"<p>\u672c\u6587\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a<\/p>\n<h4><strong>\u6982\u8981<\/strong><\/h4>\n<p>Scott A. Snyder\uff1a\u7f8e\u56fd\u829d\u52a0\u54e5\u5927\u5b66\u5316\u5b66\u7cfb\u6559\u6388\uff0c\u6709\u673a\u5316\u5b66\u5bb6\u3002\u8bfe\u9898\u7ec4\u4e3b\u9875\uff1a<a href=\"http:\/\/snyder-group.uchicago.edu\/\">http:\/\/snyder-group.uchicago.edu\/<\/a><\/p>\n<h4><strong>\u7ecf\u5386<\/strong><\/h4>\n<ul>\n<li>1995\u5e74-1999\u5e74 \u5a01\u5ec9\u59c6\u65af\u5b66\u9662\u83b7\u5f97\u5316\u5b66\u5b66\u58eb\u5b66\u4f4d\uff08Professor J. Hodge Markgraf\uff09<\/li>\n<li>1999\u5e74-2004\u5e74 \u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240\u83b7\u5f97\u6709\u673a\u5316\u5b66\u535a\u58eb\u5b66\u4f4d\uff08<a href=\"\/\/www.gsbet888.com\/chemists\/2015\/01\/k\u00b7c\u00b7\u5c3c\u53e4\u52b3-k-c-nicolaou.html\">Professor K. C. Nicolaou<\/a>\uff09<\/li>\n<li>2004\u5e74-2006\u5e74 NIH\u535a\u58eb\u540e\uff08<a href=\"\/\/www.gsbet888.com\/chemists\/2015\/01\/post-3544.html\">Professor E. J. Corey<\/a>\uff09<\/li>\n<li>2006\u5e74-2011\u5e74 \u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u5316\u5b66\u7cfb\u52a9\u7406\u6559\u6388<\/li>\n<li>2011\u5e74-2013\u5e74 \u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u5316\u5b66\u7cfb\u526f\u6559\u6388\uff08\u7ec8\u8eab\u5236\uff09<\/li>\n<li>2013\u5e74-2015\u5e74 \u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240\u5316\u5b66\u7cfb\u526f\u6559\u6388\uff08\u7ec8\u8eab\u5236\uff09<\/li>\n<li>2015\u5e74-\u81f3\u4eca \u00a0\u00a0\u00a0\u829d\u52a0\u54e5\u5927\u5b66\u5316\u5b66\u7cfb\u6559\u6388<\/li>\n<li>2018\u5e74-\u81f3\u4eca \u00a0\u00a0\u00a0\u829d\u52a0\u54e5\u5927\u5b66\u5316\u5b66\u7cfb\u6559\u6388\u526f\u4e3b\u5e2d<\/li>\n<li>2018\u5e74-\u81f3\u4eca \u00a0\u00a0\u00a0\u829d\u52a0\u54e5\u5927\u5b66\u7cfb\u4e3b\u4efb<\/li>\n<\/ul>\n<h4><strong>\u83b7\u5956\u7ecf\u5386<\/strong><\/h4>\n<ul>\n<li>Visiting Professor, IIT\u2013Bombay, 2019<\/li>\n<li>Swiss Chemical Society Lectureship, 2018<\/li>\n<li>Llewellyn John and Harriet Manchester Quantrell Award for Excellence in Undergraduate<\/li>\n<li>Teaching, University of Chicago, 2017<\/li>\n<li>The Chemical Record Lectureship, 2013<\/li>\n<li>Amgen Young Investigator Award, 2012<\/li>\n<li>Arthur C. Cope Scholar Award from the American Chemical Society, 2011<\/li>\n<li>DuPont Young Professor Award, 2011<\/li>\n<li>Alfred P. Sloan Foundation Research Fellowship, 2010<\/li>\n<li>Bristol-Myers Squibb Unrestricted Grant in Synthetic Organic Chemistry, 2010<\/li>\n<li>Eli Lilly Grantee Award, 2009<\/li>\n<li>National Institutes of Health Postdoctoral Fellowship, 2004<\/li>\n<li>Bristol-Myers Squibb Graduate Fellowship in Synthetic Organic Chemistry, 2003<\/li>\n<li>Lesly Starr Shelton Award for Excellence in Chemistry Graduate Studies at TSRI, 2003<\/li>\n<li>Graduate fellowship from Pfizer, Inc., 2002<\/li>\n<li>Best Talk Prize at the annual TSRI graduate retreat, 2002<\/li>\n<li>National Science Foundation Predoctoral Fellowship, 1999<\/li>\n<li>Elected to Associate Membership in Sigma Xi, 1999<\/li>\n<li>John Sabin Adriance Prize at Williams College, 1999<\/li>\n<li>Frank C. Goodrich Prize at Williams College, 1999<\/li>\n<li>Barry M. Goldwater Science and Engineering Fellowship, 1998<\/li>\n<li>Elected to the Williams College Chapter of Phi Beta Kappa, 1998<\/li>\n<li>Pfizer Undergraduate Summer Research Fellowship in Synthetic Organic Chemistry, 1997<\/li>\n<li>Harold H. Warren Prize at Williams College, 1996<\/li>\n<li>Semifinalist in the Westinghouse Science Talent Search, 1995<\/li>\n<li>National Finalist in the United States Chemistry Olympiad, 1995<\/li>\n<\/ul>\n<h4><strong>\u7814\u7a76\u65b9\u5411<\/strong><\/h4>\n<p>Scott A. Snyder\u6559\u6388\u53d7\u5230\u5927\u81ea\u7136\u901a\u8fc7\u9ad8\u5ea6\u53d7\u63a7\u7684\u73af\u5316\u548c\u529f\u80fd\u5316\u5316\u5b66\u65b9\u6cd5\u5bf9\u6210\u5343\u4e0a\u4e07\u79cd\u5929\u7136\u4ea7\u7269\u8fdb\u884c\u5316\u5b66\u9009\u62e9\u6027\u5408\u6210\u7684\u7075\u611f\uff0c\u4ece\u800c\u63d0\u4f9b\u4e86\u8bfe\u9898\u7ec4\u7814\u7a76\u7684\u601d\u8def\uff0c\u5e76\u786e\u5b9a\u4e86\u503c\u5f97\u5b9e\u9a8c\u5ba4\u6df1\u5165\u7814\u7a76\u7684\u6700\u7ec8\u76ee\u6807\u3002 \u8fc4\u4eca\u4e3a\u6b62\uff0cSnyder\u6559\u6388\u7684\u5de5\u4f5c\u96c6\u4e2d\u5728\u4f4e\u805a\u591a\u915a\u3001\u5929\u7136\u4ea7\u7269\u7684\u5364\u5316\u3001\u7acb\u4f53\u5316\u5b66\u5bc6\u96c6\u7684\u841c\u70ef\u548c\u591a\u73af\u751f\u7269\u78b1\u7b49\u65b9\u9762\u7684\u5168\u5408\u6210\uff0c\u5e76\u63d0\u4f9b\u4e86\u51e0\u79cd\u5e94\u7528\u4e8e\u5929\u7136\u4ea7\u7269\u5408\u6210\u4e2d\u5177\u6709\u5e7f\u6cdb\u9002\u7528\u6027\u7684\u65b0\u8bd5\u5242\u3001\u65b0\u7b56\u7565\u548c\u65b0\u65b9\u6cd5\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/1-35.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-34615 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/1-35.jpg\" alt=\"\" width=\"809\" height=\"582\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/1-35.jpg 809w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/1-35-300x216.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/1-35-680x489.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/1-35-768x553.jpg 768w\" sizes=\"(max-width: 809px) 100vw, 809px\" \/><\/a><\/p>\n<p><span style=\"color: #0000ff;\"><strong>1. \u5316\u5b66\u9009\u62e9\u6027\u5364\u5316<\/strong><\/span><\/p>\n<p>\u5364\u5316\u53cd\u5e94\u5df2\u5e7f\u6cdb\u7528\u4e8e\u533b\u836f\u3001\u519c\u836f\u3001\u67d3\u6599\u3001\u9999\u6599\u3001\u589e\u5851\u5242\u3001\u963b\u71c3\u5242\u7b49\u53ca\u5176\u4e2d\u95f4\u4f53\u7b49\u884c\u4e1a\uff0c\u5236\u53d6\u5404\u79cd\u91cd\u8981\u7684\u539f\u6599\u3001\u7cbe\u7ec6\u5316\u5b66\u54c1\u7684\u4e2d\u95f4\u4f53\u4ee5\u53ca\u5de5\u4e1a\u6eb6\u5242\u7b49\uff0c\u662f\u6709\u673a\u5408\u6210\u7684\u91cd\u8981\u5c97\u4f4d\u4e4b\u4e00\u3002\u5982\u4f55\u9ad8\u5316\u5b66\u9009\u62e9\u6027\u548c\u7acb\u4f53\u63a7\u5236\u7684\u5364\u5316\u53cd\u5e94\u5f15\u8d77\u4e86\u8bb8\u591a\u79d1\u5b66\u5bb6\u7684\u5174\u8da3\u3002Snyder\u6559\u6388\u5f00\u53d1\u4e86\u4e00\u7c7b\u5e7f\u6cdb\u6709\u6548\u7684\u5316\u5b66\u9009\u62e9\u6027\u5364\u5316\u8bd5\u5242<sup>1-3<\/sup>\u3002\uff08\u5176\u4e2dEt<sub>2<\/sub>SBr\u2022SbCl<sub>5<\/sub>Br\uff08BDSB\uff09\u662f\u65d7\u8230\u4ea7\u54c1\uff0c\u53ef\u4eceSigma-Aldrich\u8d2d\u4e70\uff09\u3002\u5728\u5408\u6210\u5b9e\u4f8b\u4e2d\u8bc1\u660e\u4e86\u8be5\u7c7b\u5364\u5316\u8bd5\u5242\u7684\u9ad8\u6548\u6027\u548c\u9009\u62e9\u6027\uff0c\u5176\u4e2d\u5305\u62ec\uff1a1\uff09\u901a\u8fc76\u6b21\u5168\u5408\u6210\u4ee5\u53ca\u6b63\u5f0f\u5168\u5408\u6210\uff08\u5305\u62ecPeysonnol A\uff09\u8bc1\u660e\u4e86\u8be5\u7c7b\u8bd5\u5242\u662f\u7b2c\u4e00\u79cd\u7531\u5364\u4ee3\u5f15\u53d1\u5b9e\u73b0\u9ad8\u5ea6\u591a\u6837\u5316\u7684\u841c\u70ef\u7684\u591a\u70ef\u73af\u5316\u53cd\u5e94\u7684\u5316\u5408\u7269\uff1b2\uff09\u4f7f\u7528\u8be5\u7c7b\u5364\u4ee3\u8bd5\u5242\u5b9e\u73b0\u4e86Laurencia\u7c7b<sup>4,5<\/sup>\u76848\uff0d\u548c9\uff0d\u6eb4\u4ee3\u7269\u7684\u5408\u6210\uff0c\u5e76\u5728laurefucin\u7684\u5408\u6210\u4e2d\u4f7f\u7528\u72ec\u7279\u7684\u751f\u7269\u9057\u4f20\u5047\u8bbe\u5b8c\u6210\u4e86\u5176\u4ed6\u5364\u7d20\u6e90\u65e0\u6cd5\u5b9e\u73b0\u7684\u4f4d\u7f6e\u9009\u62e9\u6027\u4eb2\u7535\u82b3\u65cf\u53d6\u4ee3\uff1b3\uff09\u8418\u4e8c\u915aA1\u5168\u5408\u6210\u7684\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u70ef\u70c3\u4e8c\u6c2f\u5316\uff0c\u8bc1\u660e\u4e86\u5364\u5316\u8bd5\u5242\u5728\u70ef\u70c3\u7684\u4e0d\u5bf9\u79f0\u5364\u5316\u65b9\u9762\u7684\u6f5c\u5728\u4ef7\u503c\uff08\u56fe 1\uff09\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/2-30.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-34605 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/2-30.jpg\" alt=\"\" width=\"629\" height=\"440\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/2-30.jpg 629w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/2-30-300x210.jpg 300w\" sizes=\"(max-width: 629px) 100vw, 629px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe 1 \u5316\u5b66\u9009\u62e9\u6027\u5364\u5316\uff08\u56fe\u6765\u81eaSnyder\u6559\u6388\u8bfe\u9898\u7ec4\u4e3b\u9875\uff09<\/p>\n<p><span style=\"color: #0000ff;\"><strong>2. \u591a\u73af\u6784\u5efa\u7b56\u7565<\/strong><\/span><\/p>\n<p>Snyder\u6559\u6388\u5f00\u53d1\u4e86\u8bb8\u591a\u7528\u4e8e\u5feb\u901f\u6784\u5efa\u591a\u73af\u7684\u7b56\u7565\u548c\u65b9\u6cd5<sup>6-8<\/sup>\u3002\u5982\uff1b1\uff09Snyder\u6559\u6388\u7f9f\u919b\u7f29\u5408\uff0cDiels-Alder\u5316\u5b66\u4ee5\u53ca\u73af\u6269\u5f20\uff0c\u4ee5\u7b80\u6d01\u548c\u975e\u5bf9\u6620\u4f53\u63a7\u5236\u7684\u65b9\u5f0f\uff0c\u4f7f\u7528\u5355\u4e00\u624b\u6027\u4e2d\u5fc3\u7684\u5316\u5408\u7269\u6784\u5efa\u4e86\u7acb\u4f53\u5316\u5b66\u590d\u6742\u548c\u5b98\u80fd\u56e2\u7a00\u5c11\u7684\u841c\u70efRippertenol<sup>9<\/sup>\uff1b2\uff09\u5728\u7814\u7a76\u7d27\u51d1\u578b\u751f\u7269\u78b1<sup>10<\/sup>\uff08\u4f8b\u5982Scholarisine \u548cnorsecurinines\u5bb6\u65cf\uff09\u65f6\uff0c\u5f00\u53d1\u4e86\u72ec\u7279\u7684C\uff0dH\u5b98\u80fd\u56e2\u5316<sup>11,12<\/sup>\u548cN\uff0d\u6742\u73af\u5361\u5bbe\u8bf1\u5bfc\u7684\u4e32\u8054\u7ed3\u6784<sup>13<\/sup>\uff0c\u6765\u8fc5\u901f\u6784\u5efa\u591a\u4e2a\u73af\u7cfb\u7edf\u3002 \u57fa\u4e8e\u4e0a\u9762\u7684\u5de5\u4f5c\u7684\u542f\u53d1\uff0cSnyder\u6559\u6388\u5e0c\u671b\u53ef\u4ee5\u4e3a\u5316\u5b66\u751f\u7269\u5b66\u7684\u8fdb\u4e00\u6b65\u7814\u7a76\u63d0\u4f9b\u7684\u6750\u6599\uff1b3\uff09\u5f00\u521b\u4e86\u4e00\u79cd\u57fa\u4e8e\u5bf9\u4e0d\u660e\u663e\u8d77\u59cb\u6750\u6599\u7684\u8bc6\u522b\u548c\u4e00\u4e9b\u5316\u5b66\u9009\u62e9\u6027\u8f6c\u5316\u4ee5\u53ca\u53cd\u5e94\u7ea7\u8054\u7684\u7b56\u7565\uff0c\u5b8c\u6210\u4e86\u591a\u4e2a\u4e0d\u540c\u591a\u805a\u5929\u7136\u4ea7\u7269\u5bb6\u65cf<sup>14-18<\/sup>\u53d7\u63a7\u6027\uff08\u6709\u65f6\u662f\u514b\u7ea7\uff09\u5408\u6210\uff0c\u5e76\u91ca\u653e\u5176\u6210\u5458\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u751f\u7269\u5b66\u7814\u7a76\u7684\u969c\u788d\uff08Resveratrol, Rosmarinic acid, Myrmicarin, and Coccinellid\u5bb6\u65cf\u7684\u5929\u7136\u4ea7\u7269<sup>19<\/sup>\uff09\uff1b4\uff09Snyder\u6559\u6388\u8bfe\u9898\u7ec4\u53d1\u5c55\u4e86\u4e00\u79cd\u5229\u7528\u5b63\u78b3\u4e2d\u5fc3\u9ad8\u6548\u5408\u6210\u841c\u70ef\u7c7b\u5316\u5408\u7269\u7684\u65b9\u6cd5<sup>20-22<\/sup>\uff0c\u4ed6\u4eec\u5145\u5206\u5229\u7528\u5206\u5b50\u4e2d\u7684\u6bcf\u4e00\u4e2a\u5b63\u78b3\u4e2d\u5fc3\u4ee5\u6307\u5bfc\u5176\u4ed6\u5b63\u78b3\u4e2d\u5fc3\u7684\u6784\u5efa\uff0c\u65e0\u9700\u5f15\u5165\u8fc7\u591a\u7684\u5b98\u80fd\u56e2\uff0c\u7531\u6b64\u7b80\u5316\u5206\u5b50\u7684\u5408\u6210\u8fc7\u7a0b\uff0c\u5e76\u901a\u8fc7\u8fd9\u4e00\u7b56\u7565\u5b8c\u6210\u4e86conidiogenone\u5bb6\u65cf\u5316\u5408\u7269<sup>22<\/sup>\u7684\u9ad8\u6548\u6a21\u5757\u5316\u5408\u6210\uff08\u56fe 2\uff09\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/3-32.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-34606 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/3-32.jpg\" alt=\"\" width=\"680\" height=\"666\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/3-32.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/3-32-300x294.jpg 300w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe 2 \u591a\u73af\u6784\u5efa\uff08\u56fe\u6765\u81eaSnyder\u6559\u6388\u4e3b\u9875\u4ee5\u53caNature\uff09<\/p>\n<h4><strong>\u5168\u5408\u6210\u5de5\u4f5c\u4ecb\u7ecd<\/strong><\/h4>\n<p>\uff081\uff09<a href=\"https:\/\/www.nature.com\/articles\/nature10197\"> Regioselective reactions for programmable resveratrol oligomer synthesis<\/a><\/p>\n<blockquote><p>Snyder, S. A., Gollner, A. &amp; Chiriac, M. <em>Nature, <\/em>(2011) <strong>474<\/strong>, 461-466, DOI: <a href=\"https:\/\/www.nature.com\/articles\/nature10197\">10.1038\/nature10197.<\/a><\/p><\/blockquote>\n<p>\u767d\u85dc\u82a6\u9187\u662f\u4e00\u79cd\u975e<a href=\"https:\/\/baike.baidu.com\/item\/%E9%BB%84%E9%85%AE%E7%B1%BB\/12620829\">\u9ec4\u916e\u7c7b<\/a>\u591a\u915a\u5316\u5408\u7269\uff0c\u662f\u8bb8\u591a\u690d\u7269\u53d7\u5230\u523a\u6fc0\u65f6\u4ea7\u751f\u7684\u4e00\u79cd\u6297\u6bd2\u7d20\u3002\u4f53\u5916\u5b9e\u9a8c\u53ca\u52a8\u7269\u5b9e\u9a8c\u8868\u660e\uff0c\u767d\u85dc\u82a6\u9187\u6709\u6297\u6c27\u5316\u3001\u6297\u708e\u3001\u6297\u764c\u53ca\u5fc3\u8840\u7ba1\u4fdd\u62a4\u7b49\u4f5c\u7528\u3002\u9971\u548c\u8102\u80aa\uff0d\u767d\u85dc\u82a6\u9187\u7684\u4f4e\u805a\u7269\u5c3d\u7ba1\u5177\u6709\u5f88\u9ad8\u7684\u751f\u7269\u6d3b\u6027\uff0c\u4f46\u4ecd\u88ab\u5e7f\u6cdb\u5ffd\u7565\u3002\u5176\u88ab\u5ffd\u7565\u7684\u4e3b\u8981\u969c\u788d\u662f\u65e0\u6cd5\u8f7b\u6613\u4ece\u5929\u7136\u4ea7\u7269\u7684\u4e2d\u5206\u79bb\u5f97\u5230\u4ee5\u53ca\u8f7b\u677e\u5730\u5408\u6210\u5236\u5907\u65b9\u9762\u7684\u6311\u6218\u3002Snyder\u6559\u6388\u901a\u8fc7\u4e09\u9636\u6bb5\u8bbe\u8ba1\u5b8c\u6210\u4e86\u767d\u85dc\u82a6\u9187\u5bb6\u65cf\u7684\u53ef\u7f16\u7a0b\uff0c\u53d7\u63a7\u548c\u6f5c\u5728\u53ef\u6269\u5c55\u7684\u5408\u6210\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u3002\u5408\u6210\u7b56\u7565\u548c\u8bd5\u5242\u6307\u5bfc\u7684\u5316\u5b66\u529f\u80fd\u5316\u4f5c\u7528\uff0c\u88ab\u7528\u6765\u533a\u5206\u591a\u4e2a\u5177\u6709\u76f8\u540c\u6216\u76f8\u4f3c\u53cd\u5e94\u6027\u7684\u4f4d\u70b9\u7684\u4e24\u4e2a\u4e0d\u540c\u6838\u5fc3\uff0c\u6700\u7ec8\u4ea7\u751f\u4e94\u4e2a\u66f4\u9ad8\u9636\u7684\u5929\u7136\u4ea7\u7269\u3002Snyder\u6559\u6388\u7684\u8fd9\u9879\u5de5\u4f5c\u8868\u660e\uff1a\u5728\u751f\u7269\u5408\u6210\u7814\u7a76\u53e6\u6709\u8bf4\u660e\u7684\u60c5\u51b5\u4e0b\uff0c\u590d\u6742\u6750\u6599\u7684\u6311\u6218\u6027\uff0c\u4f4d\u7f6e\u9009\u62e9\u6027\u529f\u80fd\u5316\u662f\u53ef\u80fd\u7684\uff0c\u5e76\u4e3a\u91ca\u653e\u540c\u7c7b\u5929\u7136\u4ea7\u7269\u7684\u751f\u5316\u6f5c\u529b\u63d0\u4f9b\u4e86\u6709\u6548\u7684\u6750\u6599\u548c\u5de5\u5177\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/4-25.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-34607 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/4-25.jpg\" alt=\"\" width=\"680\" height=\"563\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/4-25.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/4-25-300x248.jpg 300w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe 3 \u767d\u85dc\u82a6\u9187\u7684\u53d7\u63a7\u6027\u5408\u6210\uff08\u6765\u81eaNature\uff09<\/p>\n<p>\uff082\uff09<a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1179-2\">\u00a0Quaternary-centre-guided synthesis of complex polycyclic terpenes<\/a><\/p>\n<blockquote><p>Hu, P., Chi, H.M., DeBacker, K.C., &amp; Snyder, S. A. <em>Nature <\/em>(2019), <strong>569<\/strong>, 703-707, DOI: <a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1179-2\">10.1038\/s41586-019-1179-2 <\/a><\/p><\/blockquote>\n<p>\u5b63\u78b3\u4e2d\u5fc3\u666e\u904d\u5b58\u5728\u4e8e\u5929\u7136\u4ea7\u7269\uff08\u5982\u841c\u70ef\u7c7b\uff09\u548c\u836f\u7269\u5206\u5b50\u4e2d\uff0c\u5bf9\u4e8e\u5929\u7136\u4ea7\u7269\u7684\u751f\u7406\u6d3b\u6027\u6216\u836f\u7269\u7684\u4ee3\u8c22\u7a33\u5b9a\u6027\u5177\u6709\u91cd\u8981\u5f71\u54cd\u3002\u4e8b\u5b9e\u4e0a\uff0c\u88ab\u4e0d\u5c11\u4eba\u89c6\u4e3a\u5408\u6210\u201c\u6405\u5c40\u8005\u201d\u7684\u5b63\u78b3\u4e2d\u5fc3\u672c\u8eab\u8fd8\u6709\u201c\u5e26\u8def\u515a\u201d\u5c5e\u6027\uff0c\u5b83\u7684\u5b58\u5728\u53ef\u4fc3\u8fdb\u67d0\u4e9b\u7ed3\u6784\u7684\u6784\u5efa\uff0c\u5982\u901a\u8fc7Thorpe\u2013Ingold\u6548\u5e94\u63d0\u9ad8\u73af\u5316\u53cd\u5e94\u7684\u901f\u7387\u3001\u901a\u8fc7\u4f4d\u963b\u6548\u5e94\u63d0\u9ad8\u53cd\u5e94\u9009\u62e9\u6027\u3002\u57fa\u4e8e\u5b63\u78b3\u4e2d\u5fc3\u5728\u5408\u6210\u4e2d\u7684\u7279\u6b8a\u4f5c\u7528\uff0cSnyder\u6559\u6388\u8bfe\u9898\u7ec4\u53d1\u5c55\u4e86\u4e00\u79cd\u5229\u7528\u5b63\u78b3\u4e2d\u5fc3\u9ad8\u6548\u5408\u6210\u841c\u70ef\u7c7b\u5316\u5408\u7269\u7684\u65b9\u6cd5\uff0c\u4ed6\u4eec\u5145\u5206\u5229\u7528\u5206\u5b50\u4e2d\u7684\u6bcf\u4e00\u4e2a\u5b63\u78b3\u4e2d\u5fc3\u4ee5\u6307\u5bfc\u5176\u4ed6\u5b63\u78b3\u4e2d\u5fc3\u7684\u6784\u5efa\uff0c\u65e0\u9700\u5f15\u5165\u8fc7\u591a\u7684\u5b98\u80fd\u56e2\uff0c\u7531\u6b64\u7b80\u5316\u5206\u5b50\u7684\u5408\u6210\u8fc7\u7a0b\uff0c\u5e76\u901a\u8fc7\u8fd9\u4e00\u7b56\u7565\u5b8c\u6210\u4e86conidiogenone\u5bb6\u65cf\u5316\u5408\u7269\u7684\u9ad8\u6548\u6a21\u5757\u5316\u5408\u6210<sup>23<\/sup>\uff08\u56fe 4\uff09\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/5-20.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-34608 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/5-20.jpg\" alt=\"\" width=\"680\" height=\"264\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/5-20.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/5-20-300x116.jpg 300w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe 4 \u5b63\u78b3\u4e2d\u5fc3\u6307\u5bfc\u590d\u6742\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210<\/p>\n<h4>\u5176\u4ed6<\/h4>\n<ul>\n<li>Snyder\u6559\u6388\u9664\u4e86\u79d1\u7814\u505a\u7684\u597d\uff0c\u8fd8\u7ed9\u7814\u7a76\u751f\u4e0a\u73b0\u4ee3\u6709\u673a\u5408\u6210\u53cd\u5e94\uff0c\u4e3b\u8981\u5728\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u7684\u80cc\u666f\u4e0b\u4ecb\u7ecd\u53cd\u5e94\u5b9e\u4f8b\u3002\uff08\u8bfe\u7a0b\u4e3b\u9875\uff1a<a href=\"http:\/\/snyder-group.uchicago.edu\/teaching.html\">http:\/\/snyder-group.uchicago.edu\/teaching.html<\/a>\uff09<\/li>\n<li>Snyder\u6559\u6388\u7f16\u5199\u4e86\u8bb8\u591a\u6559\u79d1\u4e66\uff0c\u5982 \u300a<em>Classics in Total Synthesis II: More Targets, Strategies, Methods<\/em><em>\u300b\u300a<\/em><em>Orangic Chemistry<\/em><em>\u300b<\/em><\/li>\n<\/ul>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/6-17.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-34609 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/6-17.jpg\" alt=\"\" width=\"680\" height=\"590\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/6-17.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/6-17-300x260.jpg 300w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<ul>\n<li>[1] Zhang, Y.-A., Yaw, N. &amp; Snyder, S. A. General Synthetic Approach for the Laurencia Family of Natural Products Empowered by a Potentially Biomimetic Ring Expansion. <em>J. Am. Chem. Soc.<\/em> (2019) <strong>141<\/strong>, 7776-7788, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.9b01088\">10.1021\/jacs.9b01088<\/a>.<\/li>\n<li>[2] Schevenels, F. T., Shen, M. &amp; Snyder, S. A. Isolable and Readily Handled Halophosphonium Pre-reagents for Hydro- and Deuteriohalogenation. <em>J. Am. Chem. Soc.<\/em> (2017) <strong>139<\/strong>, 6329-6337, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.6b12653\">10.1021\/jacs.6b12653.<\/a><\/li>\n<li>[3] Snyder, S. A. &amp; Treitler, D. S. Et2SBr\u22c5SbCl5Br: An Effective Reagent for Direct Bromonium-Induced Polyene Cyclizations. <em>Angew. Chem. Int. Ed.<\/em> (2009) <strong>48<\/strong>, 7899-7903, doi:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.200903834\">10.1002\/anie.200903834.<\/a><\/li>\n<li>[4] Snyder, S. A., Brucks, A. P., Treitler, D. S. &amp; Moga, I. Concise Synthetic Approaches for the Laurencia Family: Formal Total Syntheses of (\u00b1)-Laurefucin and (\u00b1)-E- and (\u00b1)-Z-Pinnatifidenyne. <em>J. Am. Chem. Soc.<\/em> (2012) <strong>134<\/strong>, 17714-17721, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja3076988\">10.1021\/ja3076988.<\/a><\/li>\n<li>[5] Snyder, S. A., Treitler, D. S., Brucks, A. P. &amp; Sattler, W. A General Strategy for the Stereocontrolled Preparation of Diverse 8- and 9-Membered Laurencia-Type Bromoethers. <em>J. Am. Chem. Soc.<\/em> (2011) <strong>133<\/strong>, 15898-15901, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja2069449\">10.1021\/ja2069449<\/a>.<\/li>\n<li>[6] Lisnyak, V. G. &amp; Snyder, S. A. A Concise, Enantiospecific Total Synthesis of Chilocorine C Fueled by a Reductive Cyclization\/Mannich Reaction Cascade. <em>J. Am. Chem. Soc.<\/em> (2020) <strong>142<\/strong>, 12027-12033, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.0c04914\">10.1021\/jacs.0c04914.<\/a><\/li>\n<li>[7] Yi, H., Hu, P. &amp; Snyder, S. A. Development and Elucidation of a Pd-Based Cyclization\u2013Oxygenation Sequence for Natural Product Synthesis. <em>Angew. Chem. Int. Ed.<\/em> (2020). <strong>59<\/strong>, 2674-2678, doi:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.201913730\">10.1002\/anie.201913730. <\/a><\/li>\n<li>[8] Zhou, Z., Gao, A. X. &amp; Snyder, S. A. Total Synthesis of (+)-Arborisidine. <em>J. Am. Chem. Soc.<\/em> (2019) <strong>141<\/strong>, 7715-7720, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.9b03248\">10.1021\/jacs.9b03248<\/a>.<\/li>\n<li>[9] Snyder, S. A., Wespe, D. A. &amp; von Hof, J. M. A Concise, Stereocontrolled Total Synthesis of Rippertenol. <em>J. Am. Chem. Soc.<\/em> (2011) <strong>133<\/strong>, 8850-8853, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja202859f\">10.1021\/ja202859f.<\/a><\/li>\n<li>[10] Gan, P., Pitzen, J., Qu, P. &amp; Snyder, S. A. Total Synthesis of the Caged Indole Alkaloid Arboridinine Enabled by aza-Prins and Metal-Mediated Cyclizations. <em>J. Am. Chem. Soc.<\/em> (2018), <strong>140<\/strong>, 919-925, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.7b07724\">10.1021\/jacs.7b07724<\/a><\/li>\n<li>[11] Ye, Q., Qu, P. &amp; Snyder, S. A. Total Syntheses of Scaparvins B, C, and D Enabled by a Key C\u2013H Functionalization. <em>J. Am. Chem. Soc.<\/em> (2017) <strong>139<\/strong>, 18428-18431, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.7b06185\">10.1021\/jacs.7b06185.<\/a><\/li>\n<li>[12] Smith, M. W. &amp; Snyder, S. A. A Concise Total Synthesis of (+)-Scholarisine A Empowered by a Unique C\u2013H Arylation. <em>J. Am. Chem. Soc.<\/em> (2013) <strong>135<\/strong>, 12964-12967, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja406546k\">10.1021\/ja406546k<\/a>.<\/li>\n<li>[13] ElSohly, A. M., Wespe, D. A., Poore, T. J. &amp; Snyder, S. A. An Efficient Approach to the Securinega Alkaloids Empowered by Cooperative N-Heterocyclic Carbene\/Lewis Acid Catalysis. <em>Angew. Chem. Int. Ed.<\/em> (2013) <strong>52<\/strong>, 5789-5794, doi:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.201301849\">10.1002\/anie.201301849<\/a>.<\/li>\n<li>[14] Yang, M., Yin, F., Fujino, H. &amp; Snyder, S. A. The Total Synthesis of Chalcitrin. <em>J. Am. Chem. Soc.<\/em> (2019), <strong>141<\/strong>, 4515-4520, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.8b12612\">10.1021\/jacs.8b12612.<\/a><\/li>\n<li>[15] Jepsen, T. H.<em> et al.<\/em> Harnessing Quinone Methides: Total Synthesis of (\u00b1)-Vaticanol\u2005A. <em>Angew. Chem. Int. Ed.<\/em> (2014) <strong>53<\/strong>, 6747-6751, doi:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.201402858\">10.1002\/anie.201402858.<\/a><\/li>\n<li>[16] Snyder, S. A., Gollner, A. &amp; Chiriac, M. I. Regioselective reactions for programmable resveratrol oligomer synthesis. <em>Nature<\/em> , (2011), <strong>474<\/strong>, 461-466, doi:<a href=\"https:\/\/www.nature.com\/articles\/nature10197\">10.1038\/nature10197<\/a><\/li>\n<li>[17] Snyder, S. A., Breazzano, S. P., Ross, A. G., Lin, Y. &amp; Zografos, A. L. Total Synthesis of Diverse Carbogenic Complexity within the Resveratrol Class from a Common Building Block. <em>J. Am. Chem. Soc.<\/em> (2009), <strong>131<\/strong>, 1753-1765, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja806183r\">10.1021\/ja806183r.<\/a><\/li>\n<li>[18] Snyder, S. A., Zografos, A. L. &amp; Lin, Y. Total Synthesis of Resveratrol-Based Natural Products: A Chemoselective Solution. <em>Angew. Chem. Int. Ed.<\/em> (2007), <strong>46<\/strong>, 8186-8191, doi:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.200703333\">10.1002\/anie.200703333.<\/a><\/li>\n<li>[19] Sherwood, T. C., Trotta, A. H. &amp; Snyder, S. A. A Strategy for Complex Dimer Formation When Biomimicry Fails: Total Synthesis of Ten Coccinellid Alkaloids. <em>J. Am. Chem. Soc.<\/em> (2014), <strong>136<\/strong>, 9743-9753, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja5045852\">10.1021\/ja5045852<\/a><\/li>\n<li>[20] Peng, C., Arya, P., Zhou, Z. &amp; Snyder, S. A. A Concise Total Synthesis of (+)-Waihoensene Guided by Quaternary Center Analysis. <em>Angew. Chem. Int. Ed.<\/em> (2020) <strong>n\/a<\/strong>, doi:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.202004177\">10.1002\/anie.202004177.<\/a><\/li>\n<li>[21] Hu, P. &amp; Snyder, S. A. Enantiospecific Total Synthesis of the Highly Strained (\u2212)-Presilphiperfolan-8-ol via a Pd-Catalyzed Tandem Cyclization. <em>J. Am. Chem. Soc.<\/em> (2017) <strong>139<\/strong>, 5007-5010, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.7b01454\">10.1021\/jacs.7b01454.<\/a><\/li>\n<li>[22] Hu, P.<em> et al.<\/em> Quaternary-centre-guided synthesis of complex polycyclic terpenes. <em>Nature<\/em> (2019), <strong>569<\/strong>, 703-707, doi:<a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1179-2\">10.1038\/s41586-019-1179-2 <\/a><\/li>\n<li>[23] <a href=\"https:\/\/www.x-mol.com\/news\/17223\">Nature\uff1a\u4ece\u201c\u6405\u5c40\u8005\u201d\u5230\u201c\u5e26\u8def\u515a\u201d\uff0c\u5b63\u78b3\u4e2d\u5fc3\u6307\u5bfc\u7684\u590d\u6742\u841c\u70ef\u5408\u6210<\/a><\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a \u6982\u8981 Scott A. Snyder\uff1a\u7f8e\u56fd\u829d\u52a0\u54e5\u5927\u5b66\u5316\u5b66\u7cfb\u6559\u6388\uff0c\u6709\u673a\u5316\u5b66\u5bb6\u3002\u8bfe\u9898\u7ec4\u4e3b\u9875\uff1ahttp:\/\/snyder-group.uchicago.edu\/ \u7ecf\u5386 1995\u5e74-1999\u5e74 \u5a01\u5ec9\u59c6\u65af\u5b66\u9662\u83b7\u5f97\u5316\u5b66\u5b66\u58eb\u5b66\u4f4d\uff08Professor J. Hodge Markgraf\uff09 1999\u5e74-2004\u5e74 \u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240\u83b7\u5f97\u6709\u673a\u5316\u5b66\u535a\u58eb\u5b66\u4f4d\uff08Professor K. C. Nicolaou\uff09 2004\u5e74-2006\u5e74 NIH\u535a\u58eb\u540e\uff08Professor E. J. Corey\uff09 2006\u5e74-2011\u5e74 \u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u5316\u5b66\u7cfb\u52a9\u7406\u6559\u6388 2011\u5e74-2013\u5e74 \u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u5316\u5b66\u7cfb\u526f\u6559\u6388\uff08\u7ec8\u8eab\u5236\uff09 2013\u5e74-2015\u5e74 \u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240\u5316\u5b66\u7cfb\u526f\u6559\u6388\uff08\u7ec8\u8eab\u5236\uff09 2015\u5e74-\u81f3\u4eca \u00a0\u00a0\u00a0\u829d\u52a0\u54e5\u5927\u5b66\u5316\u5b66\u7cfb\u6559\u6388 2018\u5e74-\u81f3\u4eca \u00a0\u00a0\u00a0\u829d\u52a0\u54e5\u5927\u5b66\u5316\u5b66\u7cfb\u6559\u6388\u526f\u4e3b\u5e2d 2018\u5e74-\u81f3\u4eca \u00a0\u00a0\u00a0\u829d\u52a0\u54e5\u5927\u5b66\u7cfb\u4e3b\u4efb \u83b7\u5956\u7ecf\u5386 Visiting Professor, IIT\u2013Bombay, 2019 Swiss Chemical Society Lectureship, 2018 Llewellyn John and Harriet Manchester Quantrell Award for Excellence in Undergraduate Teaching, University of Chicago, 2017 The Chemical Record Lectureship, 2013 Amgen Young Investigator Award, 2012 Arthur C. Cope Scholar Award from the American Chemical Society, 2011 DuPont Young Professor Award, 2011 Alfred P. Sloan Foundation Research Fellowship, 2010 Bristol-Myers Squibb Unrestricted Grant in Synthetic Organic Chemistry, 2010 Eli Lilly Grantee Award, 2009 National Institutes of Health [&hellip;]","protected":false},"author":26,"featured_media":34610,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[212],"tags":[674,3027,3028],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2020\/08\/F-31.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-907","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/34603"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=34603"}],"version-history":[{"count":5,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/34603\/revisions"}],"predecessor-version":[{"id":34618,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/34603\/revisions\/34618"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/34610"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=34603"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=34603"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=34603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}