{"id":36064,"date":"2020-12-02T09:15:24","date_gmt":"2020-12-02T01:15:24","guid":{"rendered":"\/\/www.gsbet888.com\/?p=36064"},"modified":"2020-12-02T09:15:55","modified_gmt":"2020-12-02T01:15:55","slug":"%e5%8f%af%e8%a7%81%e5%85%89%e8%af%b1%e5%af%bc%e5%96%b9%e5%96%94%e5%95%89%e9%85%ae%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0aza-paterno-buchi%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2020\/12\/%e5%8f%af%e8%a7%81%e5%85%89%e8%af%b1%e5%af%bc%e5%96%b9%e5%96%94%e5%95%89%e9%85%ae%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0aza-paterno-buchi%e5%8f%8d%e5%ba%94.html","title":{"rendered":"\u53ef\u89c1\u5149\u8bf1\u5bfc\u55b9\u5594\u5549\u916e\u7684\u4e0d\u5bf9\u79f0Aza Patern\u00f2-B\u00fcchi\u53cd\u5e94"},"content":{"rendered":"

\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749<\/h4>\n

\u5bfc\u8bfb<\/h4>\n

\u8fd1\u65e5\uff0c\u6155\u5c3c\u9ed1\u5de5\u4e1a\u5927\u5b66\uff08Technische Universit\u00e4t M\u00fcnchen\uff09Thorsten Bach\u8bfe\u9898\u7ec4\u5728Angew. Chem. Int. Ed.\u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u4f7f\u752810 mol\uff05\u7684\u624b\u6027\u5149\u654f\u5242\uff08sensitizer\uff09\uff0c\u4e8e420 nm\u6ce2\u957f\u7167\u5c04\u4e0b\uff0c\u5b9e\u73b03-\u53d6\u4ee3\u7684\u55b9\u5594\u5549\u916e\uff08Quinoxalinones\uff09\u4e0e\u82ef\u4e59\u70ef\u7684\u4e0d\u5bf9\u79f0Aza Patern\u00f2-B\u00fcchi\u53cd\u5e94\uff0c\u83b7\u5f9714\u4e2a\u4ea7\u7269\uff0c\u4ea7\u7387\u4e3a50-99\uff05\uff0cee\u4e3a86-98\uff05\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u8ba4\u4e3a\u8be5\u53cd\u5e94\u7684\u673a\u7406\u662f\u4e9a\u80fa\u5e95\u7269\u548c\u50ac\u5316\u5242\u4e4b\u95f4\u53d1\u751f\u4e86\u4e09\u91cd\u6001\u80fd\u91cf\u8f6c\u79fb\u3002<\/p>\n

Enantioselective, Visible Light-mediated Aza Patern\u00f2-B\u00fcchiReactions of Quinoxalinones
\nXinyao Li, Johannes Gro\u00dfkopf, Christian Jandl, and Thorsten Bach
\nAngew. Chem. Int. Ed. ASAP DOI:10.1002\/anie.202013276\u00a0https:\/\/doi.org\/10.1002\/ange.202013276<\/a><\/p><\/blockquote>\n

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\u968f\u540e\uff0c\u4f5c\u8005\u5bf9\u4ea7\u72693a\u8fdb\u884c\u4e86\u884d\u751f\u5316\uff08Scheme 4\uff09\u3002\u9996\u5148\uff0c\u5c06\u5185\u9170\u80fa3a\u8fdb\u884cBoc\u4fdd\u62a4\uff0c\u5f62\u6210\u5316\u5408\u72696\uff0c\u518d\u4e0e\u683c\u6c0f\u8bd5\u5242\u8fdb\u884c\u4eb2\u6838\u8fdb\u653b\uff0c\u4ece\u800c\u83b7\u5f97N-\u4fdd\u62a4\u7684\u6c2e\u6742\u73af\u4e01\u70f77\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6240\u6709\u8f6c\u5316\u5747\u672a\u5bf9\u5149\u5b66\u7eaf\u5ea6\u9020\u6210\u5f71\u54cd\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e3a\u4e86\u8fdb\u4e00\u6b65\u786e\u8ba4\u6c2e\u6742\u73af\u4e01\u70f73\u7684\u76f8\u5bf9\u6784\u578b\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u5355\u6676\u57f9\u517b\uff0c\u4ece\u800c\u83b7\u5f97\u4e86\u5316\u5408\u72693f\u7684\u6676\u4f53\uff08Scheme 5\uff09\u3002\u5982\u56fe\u6240\u793a\uff0c\u6c2e\u6742\u73af\u4e01\u70f7\u4e2d\u7684\u82b3\u57fa\u73af\u548c\u7532\u57fa\u53d6\u4ee3\u57fa\u4e3a\u987a\u5f0f\uff0c\u56e0\u4e3a\u53cd\u5f0f\u6784\u578b\u4f1a\u5f15\u8d77\u4e24\u4e2a\u82b3\u73af\u7684\u7a7a\u95f4\u6392\u65a5\u3002\u800c\u5f02\u5e38\u884d\u5c04\u6570\u636e\u80fd\u591f\u8bc4\u4f30\u4ea7\u7269\u7684\u7edd\u5bf9\u6784\u578b\uff0c\u5982\u55b9\u5594\u5549\u916e\u7684C3\u4f4d\u7f6e\u7684C-C\u952e\u5f62\u6210\u5728\u5176Re\u9762\u4e0a\u3002\u4e0e\u5148\u524d\u5bf9\u50ac\u5316\u52422\u7684\u7814\u7a76\u76f8\u4e00\u81f4\uff0c\u6c22\u6613\u4e8e\u4e0e\u5e95\u72691a\u7ed3\u5408\uff0c\u4ece\u800c\u4fc3\u8fdb\u80fd\u91cf\u8f6c\u79fb\u4ee5\u53ca\u914d\u5408\u72693<\/sup>[2\u20221a]\u4e2dC-C\u952e\u7684\u5f62\u6210\u30021a\u7684Si\u9762\u88ab\u567b\u5428\u916e\u5b9e\u4f53\u6240\u5c4f\u853d\uff0c\u540e\u8005\u53ea\u80fd\u8ba9\u82ef\u4e59\u70ef\u4ec5\u653b\u51fbRe\u9762\u3002\u4e2d\u95f4\u76841,4-\u53cc\u81ea\u7531\u57fa8\u5728\u975e\u5bf9\u6620\u9009\u62e9\u6027\uff08ISC\uff09\u540e\u5f62\u6210\u6c2e\u6742\u73af\u4e01\u70f7\u4ea7\u72693a\u3002\u5c3d\u7ba1\u4ece\u4e09\u91cd\u60012\u5230\u82ef\u4e59\u70ef\u7684\u80fd\u91cf\u8f6c\u79fb\u5728\u80fd\u91cf\u4e0a\u662f\u53ef\u884c\u7684\uff0c\u4f46\u8fd9\u79cd\u9014\u5f84\u4e0d\u592a\u53ef\u80fd\u53d1\u751f\uff0c\u5f88\u96be\u89e3\u91ca\u4e3a\u4ec0\u4e48\u5bf9\u6620\u9009\u62e9\u6027\u5982\u6b64\u4e4b\u9ad8\uff0c\u800c\u50ac\u5316\u5242\u7684\u8d1f\u8f7d\u91cf\u4ec5\u4e3a10 mol\uff05\u3002\u53e6\u5916\uff0c\u5e94\u4f18\u90092\u4e0e\u55b9\u5594\u5549\u916e\u7684\u914d\u5408\u7269\u7684\u5206\u5b50\u5185\u80fd\u91cf\u8f6c\u79fb\u3002\u901a\u8fc7\u70ed\u529b\u5b66\u4ece\u55b9\u5594\u5549\u916e\u5355\u7535\u5b50\u8f6c\u79fb\u7684\u66ff\u4ee3\u53cd\u5e94\u9014\u5f84\u662f\u4e0d\u5229\u7684\u3002\u5c3d\u7ba1\u55b9\u5594\u5549\u916e\u7684\u4e09\u91cd\u6001\u53ef\u4ee5\u88ab\u8fd8\u539f\u5242\u6dec\u706d\uff0c\u4f46\u82ef\u4e59\u70ef\u8fd8\u539f\u662f\u4e0d\u53ef\u884c\u7684\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u5316\u5408\u72691a\u7684\u57fa\u6001\u8fd8\u539f\u7535\u4f4d\uff0c\u4ece\u800c\u8868\u660e\u4e09\u91cd\u6001\u4ec5\u662f\u4e00\u79cd\u5f31\u6c27\u5316\u5242\u3002<\/p>\n

\"\"\"\"<\/a><\/p>\n

\u6b64\u5916\uff0c\u4e0e3-\u70f7\u57fa\u5316\u7684\u5e95\u72691\u548c4\u4e0d\u540c\uff0c\u5728C3\u4f4d\u7f6e\u672a\u53d6\u4ee3\u7684\u55b9\u5594\u5549\u916e9\u4e0e\u82ef\u4e59\u70ef\u8fdb\u884c\u53cd\u5e94\u65f6\uff0c\u672a\u751f\u6210\u6c2e\u6742\u73af\u4e01\u70f7\u4ea7\u7269\uff0c\u800c\u5f62\u6210\u4e86C3\u53d6\u4ee3\u4ea7\u7269\uff08Scheme 6\uff09\u3002\u800c\u4f7f\u7528\u7532\u57fa\u4e59\u70ef\u57fa\u916e\u65f6\uff0c\u4ee5TXT\u4e3a\u975e\u624b\u6027\u5149\u654f\u5242\u8fdb\u884c\u53cd\u5e94\uff0c\u5f97\u5230\u4e24\u79cd\u4ea7\u7269\u7684\u6df7\u5408\u7269\u3002\u53cd\u5e945\u5c0f\u65f6\u540e\uff0c\u4ee533\uff05\u7684\u6536\u7387\u83b7\u5f97\u4ea7\u726911\u3002\u82e5\u7ee7\u7eed\u53cd\u5e94\uff0c\u5219\u5206\u79bb\u51fa\u53e6\u4e00\u79cd\u4ea7\u7269\uff0c\u53ef\u80fd\u4e3a\u5421\u54af12\uff08\u53ef\u80fd\u7531Paal-Knorr\u578b\u7f29\u5408\u53cd\u5e94\u5f62\u6210\uff09\u3002\u4ea7\u726911\u7684\u5f62\u6210\u8868\u660e\uff0c\u4e0e8\u76f8\u8fde\u76841,4-\u4e8c\u81ea\u7531\u57fa\u5e76\u4e0d\u63a5\u8fd1\u6c2e\u6742\u73af\u4e01\u70f7\u73af\uff0c\u800c\u662f\u5728C-\u672b\u7aef\u52a0\u6210\u5230\u7532\u57fa\u4e59\u70ef\u57fa\u916e\u7684\u7b2c\u4e8c\u4e2a\u5206\u5b50\u4e0a\u3002\u6240\u5f97\u76841,6-\u4e8c\u81ea\u7531\u57fa10\u5728C3\u78b3\u539f\u5b50\u8fdb\u884c\u03b3-\u62bd\u6c22\u53cd\u5e94\u3002\u4e0d\u5e78\u7684\u662f\uff0c11\u7684\u7a33\u5b9a\u6027\u6709\u9650\uff0c\u5bfc\u81f4\u672a\u80fd\u8fdb\u884c\u5176\u4ed6\u4e0d\u5bf9\u79f0\u53cd\u5e94\u7684\u9a8c\u8bc1\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u603b\u7ed3<\/h4>\n

\u6155\u5c3c\u9ed1\u5de5\u4e1a\u5927\u5b66Thorsten Bach\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4f7f\u752810 mol\uff05\u7684\u624b\u6027\u5149\u654f\u5242\uff0c\u4e8e420 nm\u6ce2\u957f\u7167\u5c04\u4e0b\u5b9e\u73b03-\u53d6\u4ee3\u7684\u55b9\u5594\u5549\u916e\uff08\u4e9a\u80fa\uff09\u4e0e\u82ef\u4e59\u70ef\uff08\u70ef\u70c3\uff09\u7684\u4e0d\u5bf9\u79f0Aza Patern\u00f2-B\u00fcchi\u53cd\u5e94\u3002\u5176\u4e2d\uff0c\u55b9\u5594\u5549\u916e\u7684\u5185\u9170\u80fa\u90e8\u5206\u80fd\u591f\u4e0e\u50ac\u5316\u5242\u76f4\u63a5\u8fdb\u884c\u6c22\u952e\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5bfc\u81f4\u4e09\u91cd\u6001\u80fd\u91cf\u8f6c\u79fb\u548c\u6709\u6548\u7684\u5bf9\u6620\u4f53\u5206\u5316\u3002\u800c\u82b3\u57fa\u70ef\u70c3\u7528\u4f5c\u70ef\u70c3\u5e95\u7269\uff0c\u4e0d\u4ec5\u4fdd\u8bc1\u7acb\u4f53\u5f02\u6784\u4e2d\u5fc3\u7684\u5feb\u901f\u5f62\u6210\uff0c\u800c\u4e14\u5177\u6709\u9ad8\u7684\u975e\u5bf9\u6620\u9009\u62e9\u6027\u3002<\/p>\n

\u53c2\u8003\u6587\u732e<\/h4>\n[1] Selected examples: a) O. Tsuge, M. Tashiro, K. Oe, Tetrahedron Lett.<\/em> 1968<\/strong>, 9, 3971-3974; b) J. A. Hyatt, J. S. Swenton, J. Chem. Soc., Chem. Commun<\/em>.1972<\/strong>, 1144-1145; c) T. H. Koch, K. H. Howard, Tetrahedron Lett<\/em>.1972<\/strong>, 11, 4035-4038; d) O. Tsuge, K. Oe, M. Tashiro, Tetrahedron<\/em> 1973<\/strong>, 29, 41-46; e) J. S. Swenton, J. A. Hyatt, J. Am. Chem. Soc<\/em>. 1974<\/strong>, 96, 4879-4885; f) K. A. Howard, T. H. Koch, J. Am. Chem. Soc.<\/em> 1975<\/strong>, 97, 7288-7298; g) R. M. Rodehorst, T. H. Koch, J. Am. Chem. Soc<\/em>. 1975<\/strong>, 97 7298-7304; h) S. Futamura, H. Ohta, Y. Kamiya, Bull. Chem. Soc<\/em>. Jpn<\/em>. 1982<\/strong>, 55, 2190-2194; i) T. Nishio, J. Org. Chem<\/em>. 1984<\/strong>, 49, 827-832; j) T. Nishio, J. Chem. Soc., Perkin Trans.<\/em> 1, 1990<\/strong>, 565-570.
\n[2] R. Sakamoto, T. Inada, S. Sakurai, K. Maruoka, Org. Lett<\/em>. 2016<\/strong>, 18, 6252-6255.
\n[3] E. Kumarasamy, S. K. Kandappa, R. Raghunathan, S. Jockusch, J. Sivaguru, Angew. Chem<\/em>. 2017<\/strong>, 129, 7162-7167.; Angew. Chem. Int. Ed<\/em>. 2017<\/strong>, 56, 7056-7061.
\n[4] M. R. Becker, A. D. Richardson, C. S. Schindler, Nat. Comm<\/em>. 2019<\/strong>, 10, 5095-5102.
\n[5] M. R. Becker, E. R. Wearing, C. S. Schindler, Nat. Chem.<\/em> 2020<\/strong>, 12, in press, DOI: 10.1038\/s41557-020-0541-1.<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb \u8fd1\u65e5\uff0c\u6155\u5c3c\u9ed1\u5de5\u4e1a\u5927\u5b66\uff08Technische Universit\u00e4t M\u00fcnchen\uff09Thorsten Bach\u8bfe\u9898\u7ec4\u5728Angew. Chem. Int. Ed.\u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u4f7f\u752810 mol\uff05\u7684\u624b\u6027\u5149\u654f\u5242\uff08sensitizer\uff09\uff0c\u4e8e420 nm\u6ce2\u957f\u7167\u5c04\u4e0b\uff0c\u5b9e\u73b03-\u53d6\u4ee3\u7684\u55b9\u5594\u5549\u916e\uff08Quinoxalinones\uff09\u4e0e\u82ef\u4e59\u70ef\u7684\u4e0d\u5bf9\u79f0Aza Patern\u00f2-B\u00fcchi\u53cd\u5e94\uff0c\u83b7\u5f9714\u4e2a\u4ea7\u7269\uff0c\u4ea7\u7387\u4e3a50-99\uff05\uff0cee\u4e3a86-98\uff05\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u8ba4\u4e3a\u8be5\u53cd\u5e94\u7684\u673a\u7406\u662f\u4e9a\u80fa\u5e95\u7269\u548c\u50ac\u5316\u5242\u4e4b\u95f4\u53d1\u751f\u4e86\u4e09\u91cd\u6001\u80fd\u91cf\u8f6c\u79fb\u3002 Enantioselective, Visible Light-mediated Aza Patern\u00f2-B\u00fcchiReactions of Quinoxalinones Xinyao Li, Johannes Gro\u00dfkopf, Christian Jandl, and Thorsten Bach Angew. Chem. Int. Ed. ASAP DOI:10.1002\/anie.202013276\u00a0https:\/\/doi.org\/10.1002\/ange.202013276 \u6b63\u6587 \u56db\u5143\u73af\u7684\u4ea7\u751f\uff0c\u662f\u5149\u5316\u5b66\u6807\u5fd7\u6027\u7684\u8f6c\u5316\u4e4b\u4e00\u3002\u76ee\u524d\uff0c\u70ef\u916e\u7684[2+2]\u5149\u73af\u52a0\u6210\u53cd\u5e94\uff08photocycloaddition\uff09\u5df2\u7ecf\u88ab\u7528\u4f5c\u5408\u6210\u73af\u4e01\u70f7\u7684\u5de5\u5177\uff0cPatern\u00f2-B\u00fcchi\u53cd\u5e94\u88ab\u7528\u4f5c\u5408\u6210\u6c27\u6742\u73af\u4e01\u70f7\u7684\u5de5\u5177\uff08Scheme 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exciplex\uff09\u4e0e\u82ef\u4e59\u70ef\u53d1\u751fAza Patern\u00f2-B\u00fcchi\u53cd\u5e94\uff08rac-II\uff09\u3002\u6b64\u5916\uff0c\u5728Aza Patern\u00f2-B\u00fcchi\u53cd\u5e94\u4e2d\uff0c\u70ef\u70c3\u53ef\u4f5c\u4e3a\u751f\u8272\u56e2\u3002Sivaguru[3]\u8bfe\u9898\u7ec4\u4ee5\u546b\u5428\u916e\uff08xanthone\uff09\u4f5c\u4e3a\u4e09\u91cd\u5149\u654f\u5242\u4e8e 350 nm\u7684\u6761\u4ef6\u4e0b\u8fdb\u884c\u8f90\u7167\uff0c\u53ef\u5f97\u5230\u4ea7\u7269rac-III\u3002Schindler[4]\u8bfe\u9898\u7ec4\u4f7f\u7528\u94f1\u50ac\u5316\u5242\u4f5c\u4e3a\u4f5c\u5149\u654f\u5242\uff08427 nm\uff09\uff0c\u901a\u8fc7\u82b3\u57fa\u70ef\u70c3\u5408\u6210\u4ea7\u7269rac-IV\uff0c\u8fd9\u4e9b\u82b3\u57fa\u70ef\u70c3\u901a\u8fc7\u4e09\u539f\u5b50\u675f\u7f1a\u5242\u4e0e\u809f\uff08\u548c\u8159\u7c7b\uff09\u8fde\u63a5\u3002\u8fd1\u671f\uff0cSchindler[5]\u8bfe\u9898\u7ec4\u63d0\u51fa\u4e86\u4f7f\u75282-\u5f02\u6076\u5511\u5549-3-\u7fa7\u9178\u76d0\u4f5c\u4e3a\u4e9a\u80fa\u751f\u8272\u56e2\u548c\u94f1\u914d\u5408\u7269\u4f5c\u4e3a\u5149\u654f\u5242\uff0c\u53ef\u80fd\u5b9e\u73b0\u5206\u5b50\u95f4\u7684Aza Patern\u00f2-B\u00fcchi\u53cd\u5e94\u3002 \u8fc4\u4eca\u4e3a\u6b62\uff0c\u5927\u591a\u6570\u5149\u5316\u5b66\u5408\u6210\u7684\u6c2e\u6742\u73af\u4e01\u70f7\u5747\u4e3a\u5916\u6d88\u65cb\u6df7\u5408\u7269\uff0c\u57fa\u4e8e\u8f74\u5411\u624b\u6027\u9170\u80fa\u7684\u4f7f\u7528\u662f\u83b7\u5f97\u5bf9\u6620\u4f53\u5bcc\u96c6\u5316\u5408\u7269\u6709\u6548\u65b9\u6cd5\uff0c\u8be5\u624b\u6027\u53ef\u5728Aza Patern\u00f2-B\u00fcchi\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u8fdb\u884c\u624b\u6027\u8f6c\u79fb\u3002\u5c3d\u7ba1\u6709\u963b\u8f6c\u9009\u62e9\u6027\uff08atropselective\uff09\u7684\u5149\u5316\u5b66\u53cd\u5e94\uff0c\u4f46\u5b83\u4eec\u4f9d\u8d56\u4e8e\u624b\u6027\u5e95\u7269\u7684\u4f7f\u7528\uff0c\u4e0d\u80fd\u63d0\u4f9b\u50ac\u5316\u5bf9\u6620\u9009\u62e9\u6027\u8fc7\u7a0b\u7684\u9009\u62e9\u3002\u5728\u6b64\uff0c\u6155\u5c3c\u9ed1\u5de5\u4e1a\u5927\u5b66Thorsten Bach\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4e00\u79cd\u901a\u8fc7\u4f7f\u7528\u624b\u6027\u4e09\u91cd\u6001\u5149\u654f\u5242\uff0c\u5b9e\u73b0\u55b9\u5594\u5549\u916e\u4e0e\u82ef\u4e59\u70ef\u7684\u4e0d\u5bf9\u79f0Aza Patern\u00f2-B\u00fcchi\u53cd\u5e94\uff0c\u4ece\u800c\u5408\u6210\u5149\u5b66\u7eaf\u7684\u624b\u6027\u6c2e\u6742\u73af\u4e01\u70f7\u5316\u5408\u7269\u3002 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3\uff09\u3002\u4ee5\u5316\u5408\u72694\u4e3a\u5e95\u7269\uff0c\u4f7f\u7528\u975e\u624b\u60279-\u567b\u5428\u916e\uff08TXT\uff09\u4f5c\u4e3a\u5149\u654f\u5242\uff0c\u53ef\u751f\u6210\u9884\u671f\u7684\u56db\u73af\u4ea7\u7269rac-5\u3002\u82e5\u4f7f\u7528\u624b\u6027\u567b\u5428\u916e2\u65f6\uff0c\u5219\u4ee5\u76f8\u540c\u7684\u6536\u7387\u548c\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u83b7\u5f97\u4ea7\u72695\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u5e95\u7269\u5728\u975e\u6781\u6027\u6eb6\u5242\u4e2d\u7684\u6eb6\u89e3\u5ea6\u9ad8\u4e8e\u4e0e\u55b9\u5594\u5549\u916e1\u8fdb\u884c\u5206\u5b50\u95f4\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u4f7f\u7528\u4e09\u6c1f\u7532\u82ef\u548c\u516d\u6c1f\u95f4\u4e8c\u7532\u82ef\uff08HFX\uff09\u7684\u6df7\u5408\u6eb6\u5242\uff0c\u53ef\u5728\u4f4e\u81f3-65 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5\uff09\u3002\u5982\u56fe\u6240\u793a\uff0c\u6c2e\u6742\u73af\u4e01\u70f7\u4e2d\u7684\u82b3\u57fa\u73af\u548c\u7532\u57fa\u53d6\u4ee3\u57fa\u4e3a\u987a\u5f0f\uff0c\u56e0\u4e3a\u53cd\u5f0f\u6784\u578b\u4f1a\u5f15\u8d77\u4e24\u4e2a\u82b3\u73af\u7684\u7a7a\u95f4\u6392\u65a5\u3002\u800c\u5f02\u5e38\u884d\u5c04\u6570\u636e\u80fd\u591f\u8bc4\u4f30\u4ea7\u7269\u7684\u7edd\u5bf9\u6784\u578b\uff0c\u5982\u55b9\u5594\u5549\u916e\u7684C3\u4f4d\u7f6e\u7684C-C\u952e\u5f62\u6210\u5728\u5176Re\u9762\u4e0a\u3002\u4e0e\u5148\u524d\u5bf9\u50ac\u5316\u52422\u7684\u7814\u7a76\u76f8\u4e00\u81f4\uff0c\u6c22\u6613\u4e8e\u4e0e\u5e95\u72691a\u7ed3\u5408\uff0c\u4ece\u800c\u4fc3\u8fdb\u80fd\u91cf\u8f6c\u79fb\u4ee5\u53ca\u914d\u5408\u72693[2\u20221a]\u4e2dC-C\u952e\u7684\u5f62\u6210\u30021a\u7684Si\u9762\u88ab\u567b\u5428\u916e\u5b9e\u4f53\u6240\u5c4f\u853d\uff0c\u540e\u8005\u53ea\u80fd\u8ba9\u82ef\u4e59\u70ef\u4ec5\u653b\u51fbRe\u9762\u3002\u4e2d\u95f4\u76841,4-\u53cc\u81ea\u7531\u57fa8\u5728\u975e\u5bf9\u6620\u9009\u62e9\u6027\uff08ISC\uff09\u540e\u5f62\u6210\u6c2e\u6742\u73af\u4e01\u70f7\u4ea7\u72693a\u3002\u5c3d\u7ba1\u4ece\u4e09\u91cd\u60012\u5230\u82ef\u4e59\u70ef\u7684\u80fd\u91cf\u8f6c\u79fb\u5728\u80fd\u91cf\u4e0a\u662f\u53ef\u884c\u7684\uff0c\u4f46\u8fd9\u79cd\u9014\u5f84\u4e0d\u592a\u53ef\u80fd\u53d1\u751f\uff0c\u5f88\u96be\u89e3\u91ca\u4e3a\u4ec0\u4e48\u5bf9\u6620\u9009\u62e9\u6027\u5982\u6b64\u4e4b\u9ad8\uff0c\u800c\u50ac\u5316\u5242\u7684\u8d1f\u8f7d\u91cf\u4ec5\u4e3a10 mol\uff05\u3002\u53e6\u5916\uff0c\u5e94\u4f18\u90092\u4e0e\u55b9\u5594\u5549\u916e\u7684\u914d\u5408\u7269\u7684\u5206\u5b50\u5185\u80fd\u91cf\u8f6c\u79fb\u3002\u901a\u8fc7\u70ed\u529b\u5b66\u4ece\u55b9\u5594\u5549\u916e\u5355\u7535\u5b50\u8f6c\u79fb\u7684\u66ff\u4ee3\u53cd\u5e94\u9014\u5f84\u662f\u4e0d\u5229\u7684\u3002\u5c3d\u7ba1\u55b9\u5594\u5549\u916e\u7684\u4e09\u91cd\u6001\u53ef\u4ee5\u88ab\u8fd8\u539f\u5242\u6dec\u706d\uff0c\u4f46\u82ef\u4e59\u70ef\u8fd8\u539f\u662f\u4e0d\u53ef\u884c\u7684\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u5316\u5408\u72691a\u7684\u57fa\u6001\u8fd8\u539f\u7535\u4f4d\uff0c\u4ece\u800c\u8868\u660e\u4e09\u91cd\u6001\u4ec5\u662f\u4e00\u79cd\u5f31\u6c27\u5316\u5242\u3002 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6\uff09\u3002\u800c\u4f7f\u7528\u7532\u57fa\u4e59\u70ef\u57fa\u916e\u65f6\uff0c\u4ee5TXT\u4e3a\u975e\u624b\u6027\u5149\u654f\u5242\u8fdb\u884c\u53cd\u5e94\uff0c\u5f97\u5230\u4e24\u79cd\u4ea7\u7269\u7684\u6df7\u5408\u7269\u3002\u53cd\u5e945\u5c0f\u65f6\u540e\uff0c\u4ee533\uff05\u7684\u6536\u7387\u83b7\u5f97\u4ea7\u726911\u3002\u82e5\u7ee7\u7eed\u53cd\u5e94\uff0c\u5219\u5206\u79bb\u51fa\u53e6\u4e00\u79cd\u4ea7\u7269\uff0c\u53ef\u80fd\u4e3a\u5421\u54af12\uff08\u53ef\u80fd\u7531Paal-Knorr\u578b\u7f29\u5408\u53cd\u5e94\u5f62\u6210\uff09\u3002\u4ea7\u726911\u7684\u5f62\u6210\u8868\u660e\uff0c\u4e0e8\u76f8\u8fde\u76841,4-\u4e8c\u81ea\u7531\u57fa\u5e76\u4e0d\u63a5\u8fd1\u6c2e\u6742\u73af\u4e01\u70f7\u73af\uff0c\u800c\u662f\u5728C-\u672b\u7aef\u52a0\u6210\u5230\u7532\u57fa\u4e59\u70ef\u57fa\u916e\u7684\u7b2c\u4e8c\u4e2a\u5206\u5b50\u4e0a\u3002\u6240\u5f97\u76841,6-\u4e8c\u81ea\u7531\u57fa10\u5728C3\u78b3\u539f\u5b50\u8fdb\u884c\u03b3-\u62bd\u6c22\u53cd\u5e94\u3002\u4e0d\u5e78\u7684\u662f\uff0c11\u7684\u7a33\u5b9a\u6027\u6709\u9650\uff0c\u5bfc\u81f4\u672a\u80fd\u8fdb\u884c\u5176\u4ed6\u4e0d\u5bf9\u79f0\u53cd\u5e94\u7684\u9a8c\u8bc1\u3002 \u603b\u7ed3 \u6155\u5c3c\u9ed1\u5de5\u4e1a\u5927\u5b66Thorsten Bach\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4f7f\u752810 mol\uff05\u7684\u624b\u6027\u5149\u654f\u5242\uff0c\u4e8e420 nm\u6ce2\u957f\u7167\u5c04\u4e0b\u5b9e\u73b03-\u53d6\u4ee3\u7684\u55b9\u5594\u5549\u916e\uff08\u4e9a\u80fa\uff09\u4e0e\u82ef\u4e59\u70ef\uff08\u70ef\u70c3\uff09\u7684\u4e0d\u5bf9\u79f0Aza Patern\u00f2-B\u00fcchi\u53cd\u5e94\u3002\u5176\u4e2d\uff0c\u55b9\u5594\u5549\u916e\u7684\u5185\u9170\u80fa\u90e8\u5206\u80fd\u591f\u4e0e\u50ac\u5316\u5242\u76f4\u63a5\u8fdb\u884c\u6c22\u952e\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5bfc\u81f4\u4e09\u91cd\u6001\u80fd\u91cf\u8f6c\u79fb\u548c\u6709\u6548\u7684\u5bf9\u6620\u4f53\u5206\u5316\u3002\u800c\u82b3\u57fa\u70ef\u70c3\u7528\u4f5c\u70ef\u70c3\u5e95\u7269\uff0c\u4e0d\u4ec5\u4fdd\u8bc1\u7acb\u4f53\u5f02\u6784\u4e2d\u5fc3\u7684\u5feb\u901f\u5f62\u6210\uff0c\u800c\u4e14\u5177\u6709\u9ad8\u7684\u975e\u5bf9\u6620\u9009\u62e9\u6027\u3002 \u53c2\u8003\u6587\u732e [1] Selected examples: a) O. Tsuge, M. Tashiro, K. Oe, Tetrahedron Lett. 1968, 9, 3971-3974; b) J. A. Hyatt, J. S. Swenton, J. Chem. Soc., Chem. Commun.1972, 1144-1145; c) T. H. Koch, K. H. 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