{"id":36731,"date":"2021-01-13T08:00:33","date_gmt":"2021-01-13T00:00:33","guid":{"rendered":"\/\/www.gsbet888.com\/?p=36731"},"modified":"2021-01-13T11:20:35","modified_gmt":"2021-01-13T03:20:35","slug":"%e8%8d%af%e7%89%a9%e5%8c%96%e5%ad%a6%e4%b8%93%e4%b8%9a%e5%bf%85%e7%9c%8b%ef%bc%9a%e5%9f%ba%e6%9c%ac%e8%8d%af%e7%89%a9%e4%b8%ad%e7%9a%84%e8%8d%af%e7%89%a9%e5%8c%96%e5%ad%a6-%ef%bc%882%ef%bc%89%e7%bb%93","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2021\/01\/%e8%8d%af%e7%89%a9%e5%8c%96%e5%ad%a6%e4%b8%93%e4%b8%9a%e5%bf%85%e7%9c%8b%ef%bc%9a%e5%9f%ba%e6%9c%ac%e8%8d%af%e7%89%a9%e4%b8%ad%e7%9a%84%e8%8d%af%e7%89%a9%e5%8c%96%e5%ad%a6-%ef%bc%882%ef%bc%89%e7%bb%93.html","title":{"rendered":"\u836f\u7269\u5316\u5b66\u4e13\u4e1a\u5fc5\u770b\uff1a\u57fa\u672c\u836f\u7269\u4e2d\u7684\u836f\u7269\u5316\u5b66 \uff082\uff09\u7ed3\u6784\u7279\u70b9"},"content":{"rendered":"<p><strong>1 <\/strong><strong>\u5143\u7d20\u7ec4\u6210<\/strong><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/1-1-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-36720 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/1-1-1.png\" alt=\"\" width=\"552\" height=\"477\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/1-1-1.png 552w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/1-1-1-300x259.png 300w\" sizes=\"(max-width: 552px) 100vw, 552px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe1 \u5143\u7d20\u7ec4\u6210<\/p>\n<p>\u4f5c\u8005\u5206\u6790\u4e86\u57fa\u672c\u836f\u7269EM\u4e2d\u5316\u5408\u7269\u9664\u78b3\u6c22\u6c27\u6c2e\u5916\u7684\u5176\u5b83\u5143\u7d20\u7ec4\u6210\uff0c\u6700\u591a\u4e3a\u786b\u5143\u7d20\uff0820%\uff09\uff0c\u5b83\u5373\u53ef\u4ee5\u505a\u4f5c\u4e3a\u5b98\u80fd\u56e2\uff08n = 40\uff09\uff0c\u4e5f\u662f\u6742\u73af\u4e2d\u7684\u539f\u5b50\uff08n = 33\uff09\uff0c\u5982\u56fe1\u6240\u793a\u3002\u53e6\u4e00\u4e2a\u7a81\u8d77\u7684\u4e00\u4e2a\u5143\u7d20\u4e3a\u6c1f\uff0c\u4ece1950s\u5f00\u59cb\u542b\u6c1f\u7684\u836f\u7269\u9010\u6e10\u589e\u52a0\uff0c\u57fa\u672c\u836f\u7269\u76ee\u5f55\u4e2d\u7ea6\u670911%\u7684\u836f\u7269\u542b\u6c1f\uff0c\u5982\u679c\u53ea\u8ba1\u7b972000\u5e74\u540e\u7684\u4e0a\u5e02\u836f\u7269\uff0c\u8fd9\u4e2a\u6bd4\u4f8b\u4e0a\u5347\u81f320%\u3002\u4e0e\u4e4b\u76f8\u53cd\u7684\u662f\u542b\u6c2f\u836f\u7269\uff0c\u4ece1980s\u768417%\uff0c\u57282000\u5e74\u540e\u4e0b\u964d\u523010%\uff0c\u5e73\u5747\u4e3a16%\u3002\u690d\u7269\u754c\u5e76\u4e0d\u6444\u53d6\u5364\u7d20\u8fdb\u884c\u751f\u7269\u5408\u6210\uff0c\u56e0\u6b64\u5929\u7136\u4ea7\u7269\u4e2d\u4e0d\u542b\u6c1f\uff0c\u542b\u6c2f\u836f\u7269\u4e5f\u4e0d\u662f\u6765\u81ea\u690d\u7269\u3002\u542b\u6eb4\u7684\u836f\u7269\u53ea\u6709\u5438\u5165\u9ebb\u9189\u5242\u4e09\u6c1f\u6eb4\u6c2f\u4e59\u70f7\u548c\u6297\u7ed3\u6838\u75c5\u7684\u8d1d\u8fbe\u55b9\u5549\u5165\u56f4\u3002\u7898\u5b58\u5728\u4e8e\u6297\u5fc3\u5f8b\u5931\u5e38\u836f\u80fa\u7898\u916e\u548c\u5de6\u65cb\u7532\u72b6\u817a\u7d20\u3002<\/p>\n<p>\u78f7\u4f5c\u4e3a\u751f\u7269\u5fc5\u987b\u7684\u5143\u7d20\uff0c\u7ea63%\u7684EM\u542b\u78f7\u5143\u7d20\uff0c\u5728\u836f\u7269\u5206\u5b50\u4e2d\u4e3b\u8981\u4ee5\u78f7\u9178\u5f62\u5f0f\u5b58\u5728\uff0c\u5982\u6297\u751f\u7d20\u78f7\u9709\u7d20fosfomycin\uff0c\u7ef4\u751f\u7d20B12\u7f9f\u94b4\u80fahydroxocobalamin\uff0c\u6297\u9aa8\u8d28\u758f\u677e\u836f\u53cc\u81a6\u9178\u5511\u6765\u81a6\u9178zoledronic acid\uff0c\u8fd1\u5e74\u6765\u78f7\u9170\u80fa\u8fd8\u4f5c\u4e3aProTide\u524d\u836f\u5f62\u5f0f\uff0c\u5982\u6297\u4e19\u809d\u795e\u836f\u7d22\u83f2\u5e03\u97e6sofosbuvir\uff0c\u5178\u578b\u5316\u5408\u7269\u5982\u56fe2\u6240\u793a\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-36721 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/2-680x472.png\" alt=\"\" width=\"680\" height=\"472\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/2-680x472.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/2-300x208.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/2-768x533.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/2.png 872w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe2 \u542b\u78f7\u5143\u7d20\u7684\u836f\u7269<\/p>\n<p>\u9664\u6b64\u4e4b\u5916\uff0c\u8fd8\u6709\u542b\u94c2\u7684\u6297\u80bf\u7624\u836f\u5361\u94c2\u548c\u5965\u6c99\u5229\u94c2\uff0c\u542b\u787c\u7684\u787c\u66ff\u4f50\u7c73bortezomib\u7ed3\u5408\u5728\u86cb\u767d\u9176\u4f53\u768426S\u50ac\u5316\u4f4d\u70b9\uff0c\u975e\u5185\u9170\u80fa\u7ed3\u6784\u7684\u6297\u751f\u7d20\u6cd5\u787c\u5df4\u5766vaborbactam\uff0c\u836f\u7269\u7ed3\u6784\u5982\u56fe3\u6240\u793a\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-36722 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/3.png\" alt=\"\" width=\"500\" height=\"166\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/3.png 500w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/3-300x100.png 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe3 \u542b\u787c\u5143\u7d20\u7684\u836f\u7269<\/p>\n<p>\u5176\u5b83\u5143\u7d20\u8fd8\u6709\u7f8e\u62c9\u80c2\u9187\u4e2d\u7684\u7837\u5143\u7d20\uff0c\u8461\u8404\u7cd6\u9178\u9511\u94a0\u4e2d\u7684\u9511\u5143\u7d20\uff0c\u7f9f\u94b4\u80fa\u4e2d\u7684\u94b4\u5143\u7d20\uff0c\u785d\u666e\u94a0\u4e2d\u7684\u94c1\u5143\u7d20\u7b49\u3002<\/p>\n<p><strong>2 <\/strong><strong>\u6700\u6709\u4ee3\u8868\u6027\u7684\u5b98\u80fd\u56e2\u548c\u6742\u73af<\/strong><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-36723 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/4-680x384.png\" alt=\"\" width=\"680\" height=\"384\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/4-680x384.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/4-300x170.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/4-768x434.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/4.png 892w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe4. \u57fa\u672c\u836f\u7269\u4e2d\u5b98\u80fd\u56e2\u51fa\u73b0\u7684\u9891\u7387<\/p>\n<p>\u7f9f\u57fa\u662f\u6700\u6709\u4ee3\u8868\u6027\u7684\u5b98\u80fd\u56e2\uff0c\u6709165\u4e2a\u836f\u7269\u542b\u6709\u7f9f\u57fa\uff0c\u7ea6\u536050%\u3002\u5176\u6b21\u4e3a\u80fa\uff08n = 117\uff09\uff0c\u5176\u4e2d\u5305\u542b64\u4e2a\u8102\u80aa\u80fa\u548c52\u4e2a\u82b3\u9999\u80fa\uff0c\u7b2c\u4e09\u4e3a\u9170\u80fa\uff08n = 94\uff09\uff0c81\u4e2a\u81f3\u5c11\u542b\u4e00\u4e2a\u7ebf\u6027\u9170\u80fa\uff0c13\u4e2a\u4e3a\u5185\u9170\u80fa\uff0c\u7b2c\u56db\u4e3a\u916f\uff08n = 72\uff09\uff0c\u5176\u6b21\u4e3a\u919a\uff08n = 71\uff09\uff0c\u5982\u56fe4\u6240\u793a\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/5.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-36724 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/5-680x419.png\" alt=\"\" width=\"680\" height=\"419\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/5-680x419.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/5-300x185.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/5-768x473.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/5-233x144.png 233w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/5.png 916w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe5. \u57fa\u672c\u836f\u7269\u4e2d\u6742\u73af\u51fa\u73b0\u7684\u9891\u7387<\/p>\n<p>\u5728\u542b\u6c27\u6742\u73af\u4e2d\uff0c\u4f9d\u636e\u6570\u91cf\u4f9d\u6b21\u4e3a\u5421\u5583\u7cd6\u3001\u544b\u5583\u7cd6\u3001\u5927\u73af\u5185\u916f\u3001\u544b\u5583\u7b49\u3002\u5728\u542b\u6c2e\u6742\u73af\u4e2d\uff0c\u4f9d\u6b21\u4e3a\u54cc\u5576\u3001\u54aa\u5511\u3001\u5421\u5576\u3001\u54cc\u55ea\u3001\u56db\u6c22\u5421\u54af\uff0c\u5982\u56fe5\u6240\u793a\u3002<\/p>\n<p><strong>3 <\/strong><strong>\u5047\u9633\u6027\u5316\u5408\u7269<\/strong><strong>PAINS<\/strong><\/p>\n<p>2010\u5e74J. B. Baell\u548cG. A. Holloway\u5f15\u5165\u4e86\u5047\u9633\u6027\u5316\u5408\u7269PAINS\uff08pan-assay interference compounds\uff09\u7684\u6982\u5ff5\uff0c\u8fd9\u7c7b\u5316\u5408\u7269\u5177\u6709\u6d3b\u6027\u7684\u4e0d\u662f\u771f\u6b63\u7cbe\u786e\u4f5c\u7528\u4e8e\u9776\u86cb\u767d\u4e0a\uff0c\u5177\u6709\u5e72\u6270\u6027\uff0c\u6210\u4e3a\u836f\u7269\u7814\u53d1\u4e2d\u7684\u201c\u5fc3\u5934\u4e4b\u75db\u201d\u3002\u6240\u5e78\u7684\u662fPAINS\u53ef\u7ecf\u8fc7\u8ba1\u7b97\u7b5b\u9009\u8fc7\u6ee4\uff0c\u5e2e\u52a9\u836f\u7269\u5316\u5b66\u5bb6\u9274\u522b\u771f\u6b63\u7684\u9ad8\u6d3b\u6027\u5316\u5408\u7269\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/6.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-36725 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/6-680x440.png\" alt=\"\" width=\"680\" height=\"440\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/6-680x440.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/6-300x194.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/6-768x497.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/6.png 1036w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe6 \u57fa\u672c\u836f\u7269\u4e2d\u7684PAINS\u7ed3\u6784<\/p>\n<p>PAINS\u7ed3\u6784\u6570\u91cf\u4f17\u591a\uff0c\u4f5c\u8005\u901a\u8fc7OpenEye\u8f6f\u4ef6\u4e2d\u7684FILTER\u7a0b\u5e8f\uff0c\u53d1\u73b0\u53ea\u670912\u4e2a\u836f\u7269\u542b\u6709PAINS\u7ed3\u6784\uff0c\u5982\u56fe6\u6240\u793a\uff0c\u4ec5\u5360EM\u76843%\u3002<\/p>\n<p><strong>4 <\/strong><strong>\u8b66\u793a\u7ed3\u6784<\/strong><\/p>\n<p>\u8b66\u793a\u7ed3\u6784Structural Alerts\u662f\u5316\u5408\u7269\u4e2d\u7684\u67d0\u4e9b\u5b98\u80fd\u56e2\u6216\u4e9a\u7ed3\u6784\uff0c\u4e0e\u7279\u6b8a\u6027\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u76f8\u5173\uff0c\u901a\u5e38\u4f1a\u5f71\u54cd\u4eba\u4f53\u7684\u809d\u810f\u3001\u76ae\u80a4\u6216\u8840\u6db2\u3002\u836f\u7269\u6bd2\u6027\u53ef\u80fd\u4e0e\u5316\u5408\u7269\u672c\u8eab\u7684\u7ed3\u6784\u65e0\u5173\uff0c\u800c\u662f\u4e0e\u4ee3\u8c22\u4ea7\u7269\u76f8\u5173\uff0c\u5982\u4ee3\u8c22\u4ea7\u7269\u7684\u4eb2\u7535\u6027\u6d3b\u6027\u57fa\u56e2\u53ef\u80fd\u4e0e\u86cb\u767d\u8d28\u5f62\u6210\u5171\u4ef7\u952e\u3002\u73b0\u5728\u5df2\u6709\u8fd1\u767e\u4e2a\u8b66\u793a\u7ed3\u6784\uff0c\u8bbe\u8ba1\u836f\u7269\u65f6\u9700\u907f\u514d\uff0c\u4ee5\u51cf\u5c0f\u5019\u9009\u836f\u7269\u7684\u6bd2\u6027\uff0c\u56fe7\u5217\u51fa\u4e86\u8fd9\u4e9b\u8b66\u793a\u7ed3\u6784\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/7.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-36726 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/7-680x446.png\" alt=\"\" width=\"680\" height=\"446\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/7-680x446.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/7-300x197.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/7-768x504.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/7-260x170.png 260w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/7.png 784w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe7 \u57fa\u672c\u836f\u7269\u4e2d\u7684\u8b66\u793a\u7ed3\u6784\u57fa\u56e2<\/p>\n<p>\u5176\u4e2d\u4e00\u4e9b\u6bd2\u6027\u8b66\u793a\u7ed3\u6784\u975e\u5e38\u7a00\u5c11\uff0c\u4f46\u4e5f\u6709\u4e00\u4e9b\u5e7f\u6cdb\u5b58\u5728\uff0c\u5982\u836f\u7269\u4e2d\u7684\u70ef\u70c3\u3001\u70f7\u57fa\u5364\u4ee3\u7269\u3001\u82ef\u80fa\u548c\u82ef\u915a\u7b49\u7ed3\u6784\uff0cEML\u6709\u7ea612%\u542b\u6709\u70ef\u70c3\u7ed3\u6784\uff0c\u5bf9\u4eb2\u916f\u6027\u836f\u7269\u800c\u8a00\uff0c\u66f4\u5bb9\u6613\u88abCYP\u6c27\u5316\u4e3a\u73af\u6c27\u5316\u7269\u3002\u5728EML\u76ee\u5f55\u4e2d\uff0c\u81f3\u5c11\u670916\u4e2a\u836f\u7269\u542b\u6709\u9ed1\u76d2\u5b50\u8b66\u544aBBW\uff08black box warnings\uff09\uff0c11\u4e2a\u836f\u7269\u542b\u6709\u4e00\u4e2a\u4ee5\u4e0a\u7684\u8b66\u793a\u7ed3\u6784\uff0c\u5982\u56fe8\u6240\u793a\u3002\u9664\u70ef\u70c3\u3001\u70f7\u57fa\u8def\u5364\u4ee3\u7269\u5916\uff0c\u8fd8\u6709\u82ef\u80fa\u3001\u78fa\u9170\u80fa\u3001\u73af\u4e19\u70f7\u80fa\u7b49\u8b66\u793a\u7ed3\u6784\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/8.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-36727 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/8-680x416.png\" alt=\"\" width=\"680\" height=\"416\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/8-680x416.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/8-300x183.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/8-768x470.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/8-233x144.png 233w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/8.png 896w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe8 \u00a0\u57fa\u672c\u836f\u7269\u4e2d\u7684\u8b66\u793a\u7ed3\u6784<\/p>\n<p><strong>5 <\/strong><strong>\u624b\u6027<\/strong><\/p>\n<p>\u624b\u6027\u5bf9\u836f\u7269\u7684\u91cd\u8981\u6027\u4e0d\u8a00\u800c\u55bb\uff0c\u5728EML\u4e2d\u53ea\u670937%\u4e3a\u975e\u624b\u6027\u5316\u5408\u7269\uff0c\u5269\u4f59\u7684\u624b\u6027\u836f\u7269\u4e2d67%\u5c5e\u4e8e\u4ece\u5934\u8bbe\u8ba1\uff08n = 84\uff09\uff0c10%\u4e3a\u5929\u7136\u4ea7\u7269\uff08n = 13\uff09\uff0c\u5269\u4e0b\u768423%\u53d7\u5929\u7136\u4ea7\u7269\u7684\u542f\u53d1\uff08n = 29\uff09\uff0c\u5982\u56fe9\u6240\u793a\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/9.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-36728 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/9.png\" alt=\"\" width=\"572\" height=\"379\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/9.png 572w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/9-300x199.png 300w\" sizes=\"(max-width: 572px) 100vw, 572px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe9 \u624b\u6027\u836f\u7269\u7684\u5206\u5e03\u60c5\u51b5<\/p>\n<p>\u8fd9\u4e9b\u624b\u6027\u5316\u5408\u7269\u4e2d\uff0c169\u4e2a\u836f\u7269\u542b\u6709\u81f3\u5c11\u4e00\u4e2a\u624b\u6027\u4e2d\u5fc3\uff0c\u800c\u4e14\u53d7\u5929\u7136\u4ea7\u7269\u7684\u5f71\u54cd\u8d8a\u5927\uff0c\u624b\u6027\u4e2d\u5fc3\u8d8a\u591a\u3002\u5927\u90e8\u5206\u4ece\u5934\u8bbe\u8ba1\u7684\u836f\u7269\u7684\u624b\u6027\u4e2d\u5fc3\u6570\u91cf\u4e3a1-6\u4e2a\uff0c\u53ea\u6709\u54cc\u4ed1\u4ed6\u97e6pibrentasvir\u542b\u67098\u4e2a\u624b\u6027\u4e2d\u5fc3\u300224\u4e2a\u4e0e\u5929\u7136\u4ea7\u7269\u6709\u76f8\u5173\u7684\u836f\u7269\u542b\u670910\u4e2a\u4ee5\u4e0a\u7684\u624b\u6027\u4e2d\u5fc3\uff0c\u6700\u591a\u7684\u4e3a\u5730\u9ad8\u8f9bdigoxin\uff0821\u4e2a\u624b\u6027\u4e2d\u5fc3\uff09\uff0c\u5176\u6b21\u4e3a\u4f0a\u7ef4\u83cc\u7d20ivermectin\uff0820\u4e2a\u624b\u6027\u4e2d\u5fc3\uff09\uff0c\u5982\u56fe10\u6240\u793a\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/10.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-36729 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/10-680x420.png\" alt=\"\" width=\"680\" height=\"420\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/10-680x420.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/10-300x185.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/10-768x474.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/10-233x144.png 233w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/01\/10.png 904w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">\u56fe10 \u5178\u578b\u7684\u624b\u6027\u836f\u7269\u7ed3\u6784\uff0c\u84dd\u8272\u4e3a\u624b\u6027\u4e2d\u5fc3<\/p>\n","protected":false},"excerpt":{"rendered":"1 \u5143\u7d20\u7ec4\u6210 \u56fe1 \u5143\u7d20\u7ec4\u6210 \u4f5c\u8005\u5206\u6790\u4e86\u57fa\u672c\u836f\u7269EM\u4e2d\u5316\u5408\u7269\u9664\u78b3\u6c22\u6c27\u6c2e\u5916\u7684\u5176\u5b83\u5143\u7d20\u7ec4\u6210\uff0c\u6700\u591a\u4e3a\u786b\u5143\u7d20\uff0820%\uff09\uff0c\u5b83\u5373\u53ef\u4ee5\u505a\u4f5c\u4e3a\u5b98\u80fd\u56e2\uff08n = 40\uff09\uff0c\u4e5f\u662f\u6742\u73af\u4e2d\u7684\u539f\u5b50\uff08n = 33\uff09\uff0c\u5982\u56fe1\u6240\u793a\u3002\u53e6\u4e00\u4e2a\u7a81\u8d77\u7684\u4e00\u4e2a\u5143\u7d20\u4e3a\u6c1f\uff0c\u4ece1950s\u5f00\u59cb\u542b\u6c1f\u7684\u836f\u7269\u9010\u6e10\u589e\u52a0\uff0c\u57fa\u672c\u836f\u7269\u76ee\u5f55\u4e2d\u7ea6\u670911%\u7684\u836f\u7269\u542b\u6c1f\uff0c\u5982\u679c\u53ea\u8ba1\u7b972000\u5e74\u540e\u7684\u4e0a\u5e02\u836f\u7269\uff0c\u8fd9\u4e2a\u6bd4\u4f8b\u4e0a\u5347\u81f320%\u3002\u4e0e\u4e4b\u76f8\u53cd\u7684\u662f\u542b\u6c2f\u836f\u7269\uff0c\u4ece1980s\u768417%\uff0c\u57282000\u5e74\u540e\u4e0b\u964d\u523010%\uff0c\u5e73\u5747\u4e3a16%\u3002\u690d\u7269\u754c\u5e76\u4e0d\u6444\u53d6\u5364\u7d20\u8fdb\u884c\u751f\u7269\u5408\u6210\uff0c\u56e0\u6b64\u5929\u7136\u4ea7\u7269\u4e2d\u4e0d\u542b\u6c1f\uff0c\u542b\u6c2f\u836f\u7269\u4e5f\u4e0d\u662f\u6765\u81ea\u690d\u7269\u3002\u542b\u6eb4\u7684\u836f\u7269\u53ea\u6709\u5438\u5165\u9ebb\u9189\u5242\u4e09\u6c1f\u6eb4\u6c2f\u4e59\u70f7\u548c\u6297\u7ed3\u6838\u75c5\u7684\u8d1d\u8fbe\u55b9\u5549\u5165\u56f4\u3002\u7898\u5b58\u5728\u4e8e\u6297\u5fc3\u5f8b\u5931\u5e38\u836f\u80fa\u7898\u916e\u548c\u5de6\u65cb\u7532\u72b6\u817a\u7d20\u3002 \u78f7\u4f5c\u4e3a\u751f\u7269\u5fc5\u987b\u7684\u5143\u7d20\uff0c\u7ea63%\u7684EM\u542b\u78f7\u5143\u7d20\uff0c\u5728\u836f\u7269\u5206\u5b50\u4e2d\u4e3b\u8981\u4ee5\u78f7\u9178\u5f62\u5f0f\u5b58\u5728\uff0c\u5982\u6297\u751f\u7d20\u78f7\u9709\u7d20fosfomycin\uff0c\u7ef4\u751f\u7d20B12\u7f9f\u94b4\u80fahydroxocobalamin\uff0c\u6297\u9aa8\u8d28\u758f\u677e\u836f\u53cc\u81a6\u9178\u5511\u6765\u81a6\u9178zoledronic acid\uff0c\u8fd1\u5e74\u6765\u78f7\u9170\u80fa\u8fd8\u4f5c\u4e3aProTide\u524d\u836f\u5f62\u5f0f\uff0c\u5982\u6297\u4e19\u809d\u795e\u836f\u7d22\u83f2\u5e03\u97e6sofosbuvir\uff0c\u5178\u578b\u5316\u5408\u7269\u5982\u56fe2\u6240\u793a\u3002 \u56fe2 \u542b\u78f7\u5143\u7d20\u7684\u836f\u7269 \u9664\u6b64\u4e4b\u5916\uff0c\u8fd8\u6709\u542b\u94c2\u7684\u6297\u80bf\u7624\u836f\u5361\u94c2\u548c\u5965\u6c99\u5229\u94c2\uff0c\u542b\u787c\u7684\u787c\u66ff\u4f50\u7c73bortezomib\u7ed3\u5408\u5728\u86cb\u767d\u9176\u4f53\u768426S\u50ac\u5316\u4f4d\u70b9\uff0c\u975e\u5185\u9170\u80fa\u7ed3\u6784\u7684\u6297\u751f\u7d20\u6cd5\u787c\u5df4\u5766vaborbactam\uff0c\u836f\u7269\u7ed3\u6784\u5982\u56fe3\u6240\u793a\u3002 \u56fe3 \u542b\u787c\u5143\u7d20\u7684\u836f\u7269 \u5176\u5b83\u5143\u7d20\u8fd8\u6709\u7f8e\u62c9\u80c2\u9187\u4e2d\u7684\u7837\u5143\u7d20\uff0c\u8461\u8404\u7cd6\u9178\u9511\u94a0\u4e2d\u7684\u9511\u5143\u7d20\uff0c\u7f9f\u94b4\u80fa\u4e2d\u7684\u94b4\u5143\u7d20\uff0c\u785d\u666e\u94a0\u4e2d\u7684\u94c1\u5143\u7d20\u7b49\u3002 2 \u6700\u6709\u4ee3\u8868\u6027\u7684\u5b98\u80fd\u56e2\u548c\u6742\u73af \u56fe4. \u57fa\u672c\u836f\u7269\u4e2d\u5b98\u80fd\u56e2\u51fa\u73b0\u7684\u9891\u7387 \u7f9f\u57fa\u662f\u6700\u6709\u4ee3\u8868\u6027\u7684\u5b98\u80fd\u56e2\uff0c\u6709165\u4e2a\u836f\u7269\u542b\u6709\u7f9f\u57fa\uff0c\u7ea6\u536050%\u3002\u5176\u6b21\u4e3a\u80fa\uff08n = 117\uff09\uff0c\u5176\u4e2d\u5305\u542b64\u4e2a\u8102\u80aa\u80fa\u548c52\u4e2a\u82b3\u9999\u80fa\uff0c\u7b2c\u4e09\u4e3a\u9170\u80fa\uff08n = 94\uff09\uff0c81\u4e2a\u81f3\u5c11\u542b\u4e00\u4e2a\u7ebf\u6027\u9170\u80fa\uff0c13\u4e2a\u4e3a\u5185\u9170\u80fa\uff0c\u7b2c\u56db\u4e3a\u916f\uff08n = 72\uff09\uff0c\u5176\u6b21\u4e3a\u919a\uff08n = 71\uff09\uff0c\u5982\u56fe4\u6240\u793a\u3002 \u56fe5. \u57fa\u672c\u836f\u7269\u4e2d\u6742\u73af\u51fa\u73b0\u7684\u9891\u7387 \u5728\u542b\u6c27\u6742\u73af\u4e2d\uff0c\u4f9d\u636e\u6570\u91cf\u4f9d\u6b21\u4e3a\u5421\u5583\u7cd6\u3001\u544b\u5583\u7cd6\u3001\u5927\u73af\u5185\u916f\u3001\u544b\u5583\u7b49\u3002\u5728\u542b\u6c2e\u6742\u73af\u4e2d\uff0c\u4f9d\u6b21\u4e3a\u54cc\u5576\u3001\u54aa\u5511\u3001\u5421\u5576\u3001\u54cc\u55ea\u3001\u56db\u6c22\u5421\u54af\uff0c\u5982\u56fe5\u6240\u793a\u3002 3 \u5047\u9633\u6027\u5316\u5408\u7269PAINS 2010\u5e74J. B. Baell\u548cG. A. Holloway\u5f15\u5165\u4e86\u5047\u9633\u6027\u5316\u5408\u7269PAINS\uff08pan-assay interference compounds\uff09\u7684\u6982\u5ff5\uff0c\u8fd9\u7c7b\u5316\u5408\u7269\u5177\u6709\u6d3b\u6027\u7684\u4e0d\u662f\u771f\u6b63\u7cbe\u786e\u4f5c\u7528\u4e8e\u9776\u86cb\u767d\u4e0a\uff0c\u5177\u6709\u5e72\u6270\u6027\uff0c\u6210\u4e3a\u836f\u7269\u7814\u53d1\u4e2d\u7684\u201c\u5fc3\u5934\u4e4b\u75db\u201d\u3002\u6240\u5e78\u7684\u662fPAINS\u53ef\u7ecf\u8fc7\u8ba1\u7b97\u7b5b\u9009\u8fc7\u6ee4\uff0c\u5e2e\u52a9\u836f\u7269\u5316\u5b66\u5bb6\u9274\u522b\u771f\u6b63\u7684\u9ad8\u6d3b\u6027\u5316\u5408\u7269\u3002 \u56fe6 \u57fa\u672c\u836f\u7269\u4e2d\u7684PAINS\u7ed3\u6784 PAINS\u7ed3\u6784\u6570\u91cf\u4f17\u591a\uff0c\u4f5c\u8005\u901a\u8fc7OpenEye\u8f6f\u4ef6\u4e2d\u7684FILTER\u7a0b\u5e8f\uff0c\u53d1\u73b0\u53ea\u670912\u4e2a\u836f\u7269\u542b\u6709PAINS\u7ed3\u6784\uff0c\u5982\u56fe6\u6240\u793a\uff0c\u4ec5\u5360EM\u76843%\u3002 4 \u8b66\u793a\u7ed3\u6784 \u8b66\u793a\u7ed3\u6784Structural Alerts\u662f\u5316\u5408\u7269\u4e2d\u7684\u67d0\u4e9b\u5b98\u80fd\u56e2\u6216\u4e9a\u7ed3\u6784\uff0c\u4e0e\u7279\u6b8a\u6027\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u76f8\u5173\uff0c\u901a\u5e38\u4f1a\u5f71\u54cd\u4eba\u4f53\u7684\u809d\u810f\u3001\u76ae\u80a4\u6216\u8840\u6db2\u3002\u836f\u7269\u6bd2\u6027\u53ef\u80fd\u4e0e\u5316\u5408\u7269\u672c\u8eab\u7684\u7ed3\u6784\u65e0\u5173\uff0c\u800c\u662f\u4e0e\u4ee3\u8c22\u4ea7\u7269\u76f8\u5173\uff0c\u5982\u4ee3\u8c22\u4ea7\u7269\u7684\u4eb2\u7535\u6027\u6d3b\u6027\u57fa\u56e2\u53ef\u80fd\u4e0e\u86cb\u767d\u8d28\u5f62\u6210\u5171\u4ef7\u952e\u3002\u73b0\u5728\u5df2\u6709\u8fd1\u767e\u4e2a\u8b66\u793a\u7ed3\u6784\uff0c\u8bbe\u8ba1\u836f\u7269\u65f6\u9700\u907f\u514d\uff0c\u4ee5\u51cf\u5c0f\u5019\u9009\u836f\u7269\u7684\u6bd2\u6027\uff0c\u56fe7\u5217\u51fa\u4e86\u8fd9\u4e9b\u8b66\u793a\u7ed3\u6784\u3002 \u56fe7 \u57fa\u672c\u836f\u7269\u4e2d\u7684\u8b66\u793a\u7ed3\u6784\u57fa\u56e2 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