{"id":37172,"date":"2021-03-02T08:00:09","date_gmt":"2021-03-02T00:00:09","guid":{"rendered":"\/\/www.gsbet888.com\/?p=37172"},"modified":"2021-03-02T13:46:41","modified_gmt":"2021-03-02T05:46:41","slug":"katada%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2021\/03\/katada%e5%8f%8d%e5%ba%94.html","title":{"rendered":"Katada\u53cd\u5e94"},"content":{"rendered":"

\u6982\u8981<\/b><\/strong><\/h4>\n

Katada\u53cd\u5e94 (Katada reaction)\u662f\u5421\u5576-N<\/i><\/em>-\u6c27\u5316\u7269[1,2]<\/sup>\u3001\u55b9\u5549-N-\u6c27\u5316\u7269[3-5]<\/sup>\u4ee5\u53ca\u82ef\u5e76\u55b9\u5549-N<\/i><\/em>-\u6c27\u5316\u7269[6]<\/sup>\u5728\u9178\u9150 (\u4e59\u9178\u9150\u6216\u82ef\u7532\u9178\u9150)\u5b58\u5728\u4e0b\uff0c\u901a\u8fc7\u91cd\u6392\u4ee5\u53ca\u540e\u7eed\u7684\u6c34\u89e3\u8fc7\u7a0b\uff0c\u5206\u522b\u83b7\u5f972-\u5421\u5576\u916e\u30012-\u55b9\u5549\u916e\u4ee5\u53ca2-\u82ef\u5e76\u55b9\u5549\u916e\u7684\u53cd\u5e94[1-6]<\/sup>\u3002\u8be5\u53cd\u5e94\u7531\u65e5\u672cTokyo\u5927\u5b66\u836f\u5b66\u90e8\u836f\u7269\u7814\u7a76\u6240 (\u6771\u4eac\u5927\u5b66\u85ac\u5b66\u90e8\u85ac\u5b66\u6559\u5ba4,\u00a0Pharmaceutical Instutute, Medical Faculty,\u00a0Tokyo University)\u7684Katada\u00a0(\u5805\u7530\u00a0\u771e\u4f50,\u00a0Katada\u00a0Masa)\u7814\u7a76\u5ba4\u57281947\u5e74\u9996\u6b21\u62a5\u9053[1]<\/sup>\u3002<\/p>\n

\"\"<\/a><\/p>\n

Katada\u53cd\u5e94\u539f\u6599\u5ec9\u4ef7\u6613\u5f97\uff0c\u5177\u6709\u826f\u597d\u7684\u533a\u57df\u9009\u62e9\u6027\u4ee5\u53ca\u8f83\u597d\u7684\u53cd\u5e94\u6536\u7387\u3002\u540c\u65f6\uff0c\u8be5\u53cd\u5e94\u662f\u6742\u73af-N<\/i><\/em>-\u6c27\u5316\u7269\u5316\u5b66\u7814\u7a76\u9886\u57df\u7684\u9996\u6b21\u5c1d\u8bd5[7]<\/sup>\uff0c\u4e3a\u6742\u73af-N<\/i><\/em>-\u6c27\u5316\u7269\u76f8\u5173\u7684\u6709\u673a\u5408\u6210\u65b9\u6cd5\u5b66\u7814\u7a76\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u6307\u5bfc\u3002<\/p>\n

\u57fa\u672c\u6587\u732e<\/b><\/strong><\/h4>\n[1] M. Katada, J. Pharm. Soc. Jpn. <\/i><\/em>(<\/i><\/em>Y<\/i><\/em>akugaku<\/i><\/em>\u00a0Z<\/i><\/em>asshi)<\/i><\/em>\u00a01947<\/b><\/strong>, 67<\/i><\/em>, 51.\u00a0doi: 10.1248\/yakushi1947.67.3-4_51<\/u><\/a>.<\/u><\/p>\n[2] V. Boekelheide, W. L. Lehn, J. Org. Chem.<\/i><\/em>\u00a01961<\/b><\/strong>, 26<\/i><\/em>, 428.<\/p>\n

doi: 10.1021\/jo01061a037<\/u><\/a>.<\/u><\/p>\n[3] E. Ochiai,\u00a0T. Okamoto, J. Pharm. S<\/i><\/em>oc<\/i><\/em>. Jpn<\/i><\/em>.<\/i><\/em>\u00a0<\/i><\/em>(<\/i><\/em>Y<\/i><\/em>akugaku<\/i><\/em>\u00a0Z<\/i><\/em>asshi)<\/i><\/em>\u00a01948<\/b><\/strong>, 68<\/i><\/em>, 88.\u00a0doi: 10.1248\/yakushi1947.68.3-4_88<\/u><\/a><\/p>\n[4] E. Ochiai, T. Okamoto,\u00a0G. Kobayashi, J. Pharm. S<\/i><\/em>oc<\/i><\/em>. Jpn<\/i><\/em>. (<\/i><\/em>Y<\/i><\/em>akugaku<\/i><\/em>\u00a0Z<\/i><\/em>asshi)<\/i><\/em>\u00a01948<\/b><\/strong>,\u00a068<\/i><\/em>, 109.\u00a0doi: 10.1248\/yakushi1947.68.3-4_109<\/u><\/a>.<\/u><\/p>\n[5]\u00a0E. Ochiai, J. Org. Chem.<\/i><\/em>\u00a01953<\/b><\/strong>, 18<\/i><\/em>, 534.\u00a0doi:\u00a010.1021\/jo01133a010<\/u><\/a>.<\/u><\/p>\n[6] I. Iwai, J. Pharm. S<\/i><\/em>oc<\/i><\/em>. Jpn<\/i><\/em>.<\/i><\/em>\u00a0<\/i><\/em>(<\/i><\/em>Y<\/i><\/em>akugaku<\/i><\/em>\u00a0Z<\/i><\/em>asshi)<\/i><\/em>\u00a01951<\/b><\/strong>, 71<\/i><\/em>, 1288.\u00a0doi: 10.1248\/yakushi1947.71.11_1288<\/u><\/a>.<\/u><\/p>\n[7] D.\u00a0Andreotti, E.\u00a0Miserazzi, A.\u00a0Nalin, A.\u00a0Pozzan, R.\u00a0Profeta, S. Spada, Tetrahedron Lett<\/i><\/em>.<\/i><\/em>\u00a02010<\/b><\/strong>, 51<\/i><\/em>,\u00a06526. doi: 10.1016\/j.tetlet.2010.10.020<\/u><\/a>.<\/u><\/p>\n

\u53cd\u5e94\u673a\u7406<\/b><\/strong><\/h4>\n

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\u53cd\u5e94\u5b9e\u4f8b<\/b><\/strong><\/h4>\n

2-\u5421\u5576\u916e\u7684\u5408\u6210[<\/sup>1<\/sup>]<\/sup><\/p>\n

\"\"<\/a><\/p>\n

2-\u55b9\u5549\u916e\u7684\u5408\u6210[<\/sup>2<\/sup>]<\/sup><\/p>\n

\"\"<\/a><\/p>\n

\u5b9e\u9a8c\u6b65\u9aa4<\/b><\/strong><\/h4>\n

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\u53c2\u8003\u6587\u732e<\/b><\/strong><\/h4>\n[1]\u00a0V. Boekelheide, W. L. Lehn, J. Org. Chem.<\/i><\/em>\u00a01961<\/b><\/strong>, 26<\/i><\/em>, 428. doi: .<\/p>\n

doi: 10.1021\/jo01061a037<\/u><\/a>.<\/u><\/p>\n[2]\u00a0E. Ochiai, T. Okamoto,\u00a0G. Kobayashi, J. Pharm. S<\/i><\/em>oc<\/i><\/em>. Jpn<\/i><\/em>. (<\/i><\/em>Y<\/i><\/em>akugaku<\/i><\/em>\u00a0Z<\/i><\/em>asshi)<\/i><\/em>\u00a01948<\/b><\/strong>,\u00a068<\/i><\/em>, 109.\u00a0doi: 10.1248\/yakushi1947.68.3-4_109<\/u><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 Katada\u53cd\u5e94 (Katada reaction)\u662f\u5421\u5576-N-\u6c27\u5316\u7269[1,2]\u3001\u55b9\u5549-N-\u6c27\u5316\u7269[3-5]\u4ee5\u53ca\u82ef\u5e76\u55b9\u5549-N-\u6c27\u5316\u7269[6]\u5728\u9178\u9150 (\u4e59\u9178\u9150\u6216\u82ef\u7532\u9178\u9150)\u5b58\u5728\u4e0b\uff0c\u901a\u8fc7\u91cd\u6392\u4ee5\u53ca\u540e\u7eed\u7684\u6c34\u89e3\u8fc7\u7a0b\uff0c\u5206\u522b\u83b7\u5f972-\u5421\u5576\u916e\u30012-\u55b9\u5549\u916e\u4ee5\u53ca2-\u82ef\u5e76\u55b9\u5549\u916e\u7684\u53cd\u5e94[1-6]\u3002\u8be5\u53cd\u5e94\u7531\u65e5\u672cTokyo\u5927\u5b66\u836f\u5b66\u90e8\u836f\u7269\u7814\u7a76\u6240 (\u6771\u4eac\u5927\u5b66\u85ac\u5b66\u90e8\u85ac\u5b66\u6559\u5ba4,\u00a0Pharmaceutical Instutute, Medical Faculty,\u00a0Tokyo University)\u7684Katada\u00a0(\u5805\u7530\u00a0\u771e\u4f50,\u00a0Katada\u00a0Masa)\u7814\u7a76\u5ba4\u57281947\u5e74\u9996\u6b21\u62a5\u9053[1]\u3002 Katada\u53cd\u5e94\u539f\u6599\u5ec9\u4ef7\u6613\u5f97\uff0c\u5177\u6709\u826f\u597d\u7684\u533a\u57df\u9009\u62e9\u6027\u4ee5\u53ca\u8f83\u597d\u7684\u53cd\u5e94\u6536\u7387\u3002\u540c\u65f6\uff0c\u8be5\u53cd\u5e94\u662f\u6742\u73af-N-\u6c27\u5316\u7269\u5316\u5b66\u7814\u7a76\u9886\u57df\u7684\u9996\u6b21\u5c1d\u8bd5[7]\uff0c\u4e3a\u6742\u73af-N-\u6c27\u5316\u7269\u76f8\u5173\u7684\u6709\u673a\u5408\u6210\u65b9\u6cd5\u5b66\u7814\u7a76\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u6307\u5bfc\u3002 \u57fa\u672c\u6587\u732e [1] M. Katada, J. Pharm. Soc. Jpn. (Yakugaku\u00a0Zasshi)\u00a01947, 67, 51.\u00a0doi: 10.1248\/yakushi1947.67.3-4_51. [2] V. Boekelheide, W. L. Lehn, J. Org. Chem.\u00a01961, 26, 428. doi: 10.1021\/jo01061a037. [3] E. Ochiai,\u00a0T. Okamoto, J. Pharm. Soc. Jpn.\u00a0(Yakugaku\u00a0Zasshi)\u00a01948, 68, 88.\u00a0doi: 10.1248\/yakushi1947.68.3-4_88 [4] E. Ochiai, T. Okamoto,\u00a0G. Kobayashi, J. Pharm. Soc. Jpn. (Yakugaku\u00a0Zasshi)\u00a01948,\u00a068, 109.\u00a0doi: 10.1248\/yakushi1947.68.3-4_109. [5]\u00a0E. Ochiai, J. Org. Chem.\u00a01953, 18, 534.\u00a0doi:\u00a010.1021\/jo01133a010. [6] I. Iwai, J. Pharm. Soc. Jpn.\u00a0(Yakugaku\u00a0Zasshi)\u00a01951, 71, 1288.\u00a0doi: 10.1248\/yakushi1947.71.11_1288. [7] D.\u00a0Andreotti, E.\u00a0Miserazzi, A.\u00a0Nalin, A.\u00a0Pozzan, R.\u00a0Profeta, S. Spada, Tetrahedron Lett.\u00a02010, 51,\u00a06526. doi: 10.1016\/j.tetlet.2010.10.020. \u53cd\u5e94\u673a\u7406 \u53cd\u5e94\u5b9e\u4f8b 2-\u5421\u5576\u916e\u7684\u5408\u6210[1] 2-\u55b9\u5549\u916e\u7684\u5408\u6210[2] \u5b9e\u9a8c\u6b65\u9aa4 \u53c2\u8003\u6587\u732e [1]\u00a0V. Boekelheide, W. L. Lehn, J. Org. Chem.\u00a01961, 26, 428. doi: . doi: 10.1021\/jo01061a037. 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