{"id":37971,"date":"2021-04-06T08:00:01","date_gmt":"2021-04-06T00:00:01","guid":{"rendered":"\/\/www.gsbet888.com\/?p=37971"},"modified":"2021-04-05T00:36:40","modified_gmt":"2021-04-04T16:36:40","slug":"%e4%b8%ad%e7%a7%91%e9%99%a2%e7%a6%8f%e5%bb%ba%e7%89%a9%e6%9e%84%e6%89%80%e9%b2%8d%e7%ba%a2%e4%b8%bd%e8%af%be%e9%a2%98%e7%bb%84angew%ef%bc%9a-%e9%93%81%e5%82%ac%e5%8c%96%e8%8b%af%e4%b9%99%e7%83%af","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2021\/04\/%e4%b8%ad%e7%a7%91%e9%99%a2%e7%a6%8f%e5%bb%ba%e7%89%a9%e6%9e%84%e6%89%80%e9%b2%8d%e7%ba%a2%e4%b8%bd%e8%af%be%e9%a2%98%e7%bb%84angew%ef%bc%9a-%e9%93%81%e5%82%ac%e5%8c%96%e8%8b%af%e4%b9%99%e7%83%af.html","title":{"rendered":"\u4e2d\u79d1\u9662\u798f\u5efa\u7269\u6784\u6240\u9c8d\u7ea2\u4e3d\u8bfe\u9898\u7ec4Angew\uff1a \u94c1\u50ac\u5316\u82ef\u4e59\u70ef\u7684\u4e0d\u5bf9\u79f0\u6c28\u57fa\u53e0\u6c2e\u5316\u548c\u53cc\u53e0\u6c2e\u5316\u53cd\u5e94"},"content":{"rendered":"

\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749<\/strong><\/p>\n

\u5bfc\u8bfb<\/h4>\n

\u70ef\u70c3\u7684\u4e0d\u5bf9\u79f0\u6c28\u57fa\u53e0\u6c2e\u5316\uff08aminoazidation\uff09\u548c\u53cc\u53e0\u6c2e\u5316\uff08diazidation\uff09\u662f\u4e00\u7c7b\u6784\u5efa\u624b\u6027\u542b\u6c2e\u5316\u5408\u7269\u7684\u6709\u6548\u7b56\u7565\u3002\u8fd1\u65e5\uff0c\u4e2d\u79d1\u9662\u798f\u5efa\u7269\u6784\u6240\u9c8d\u7ea2\u4e3d\u8bfe\u9898\u7ec4\u5728Angew. Chem. Int. Ed<\/em>. \u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e86\u94c1\u50ac\u5316\u82ef\u4e59\u70ef\u5206\u5b50\u95f4\u7684\u4e0d\u5bf9\u79f0\u6c28\u57fa\u53e0\u6c2e\u5316\u548c\u53cc\u53e0\u5316\u53cd\u5e94\uff0c\u8be5\u53cd\u5e94\u4ec5\u4f7f\u7528\u8f83\u4f4e\u50ac\u5316\u91cf\u7684\u50ac\u5316\u5242\u548c\u624b\u6027\u914d\u4f53\uff0c\u901a\u8fc7\u81ea\u7531\u57fa\u673a\u7406\u8fdb\u884c\uff0c\u6d89\u53ca\u65e0\u73af\u81ea\u7531\u57fa\u7684\u7acb\u4f53\u63a7\u5236\uff08\u53ef\u80fd\u901a\u8fc7\u57fa\u56e2\u8f6c\u79fb\u8fc7\u7a0b\uff09\u3002<\/p>\n

Iron-Catalyzed Radical Asymmetric Aminoazidation and Diazidation of Styrenes<\/p>\n

Hongli Bao, Daqi Lv, Qiao Sun, Huan Zhou, Liang Ge, Yanjie Qu, Taian Li, Xiaoxu Ma, and Yajun Li<\/p>\n

Angew. Chem. Int. Ed<\/em>. ASAP DOI: 10.1002\/anie.202017175<\/a><\/p><\/blockquote>\n

\"\"<\/a><\/p>\n

\u6b63\u6587<\/h4>\n

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\u4e3a\u4e86\u8fdb\u4e00\u6b65\u8bc1\u660e\u53cd\u5e94\u7684\u5b9e\u7528\u6027\uff0c\u4f5c\u8005\u5bf9\u4ea7\u72698<\/strong>\u8fdb\u884c\u4e86\u540e\u671f\u884d\u751f\u5316\uff08Scheme 3\uff09\u3002\u9996\u5148\uff0c8<\/strong>\u53ef\u4e0e\u672b\u7aef\u6216\u5185\u7094\u70c3\u3001\u82ef\u7094\u524d\u4f53\u6216\u4e59\u9170\u4e19\u916e\u8fdb\u884c\u70b9\u51fb\u53cd\u5e94\uff08Click reactions\uff09\uff0c\u4ece\u800c\u83b7\u5f97\u9ad8\u6536\u7387\u4e14\u5bf9\u6620\u9009\u62e9\u6027\u4e0d\u635f\u5931\u7684\u4e09\u5511\u4ea7\u726957<\/strong>–62<\/strong>\u3002\u5176\u6b21\uff0c8<\/strong>\u53ef\u5728\u94df\u7c89\u7684MeOH\u4e2d\u56de\u6d41\uff0c\u83b7\u5f9779\uff05\u6536\u7387\u7684\u624b\u6027\u4f2f\u80fa63<\/strong>\u3002\u82e5\u4f7f\u7528P(OMe)3<\/sub>\u8fd8\u539f\u5316\u5408\u72698<\/strong>\uff0c\u53ef\u83b7\u5f9781\uff05\u6536\u7387\u7684\u624b\u6027\u78f7\u9170\u80fa64<\/strong>\u3002\u9664\u53e0\u6c2e\u5316\u7269\u4ee5\u5916\uff0c\u5316\u5408\u72698<\/strong>\u53ef\u7ecfn<\/em>-Bu4<\/sub>NF\u8fdb\u884c\u5355\u8131\u78fa\u9170\u5316\uff0c\u4ee5\u5b9a\u91cf\u6536\u7387\u5f97\u5230\u4ea7\u726965<\/strong>\uff0c\u82e5\u7ecf\u8fdb\u4e00\u6b65\u8fd8\u539f\u5373\u53ef\u83b7\u5f97\u5355\u4fdd\u62a4\u76841,2-\u4e8c\u80fa66<\/strong>\uff0c\u6536\u7387\u4e3a62\uff05\u300266<\/strong>\u82e5\u7ecf\u4e00\u9505\u7094\u4e19\u57fa\u5316\/\u5206\u5b50\u5185[3+2]\u73af\u52a0\u6210\u53cd\u5e94\uff0c\u53ef\u83b7\u5f97\u4e09\u5511\u5e76\u5421\u55ea\u884d\u751f\u726967<\/strong>\u3002<\/p>\n

\"\"\"\"<\/a><\/p>\n

\u4e3a\u4e86\u8fdb\u4e00\u6b65\u4e86\u89e3\u53cd\u5e94\u7684\u673a\u7406\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u76f8\u5173\u7684\u5bf9\u7167\u5b9e\u9a8c\uff08Scheme 4\uff09\u3002\u9996\u5148\uff0c\u5728\u6807\u51c6\u53cd\u5e94\u4f53\u7cfb\u4e2d\u52a0\u5165TEMPO\uff0c\u4ec5\u83b7\u5f9724\uff05\u6536\u7387\u7684\u4ea7\u72698<\/strong>\uff0c\u5e76\u5206\u79bb\u51fa14\uff05\u6536\u7387\u7684\u6c28\u57fa\u6c27\u5316\u4ea7\u726968<\/strong>\uff08Scheme 4a\uff09\u3002\u5f53\u52a0\u5165BHT\u65f6\uff0c\u53cd\u5e94\u5b8c\u5168\u88ab\u6291\u5236\uff08Scheme 4b\uff09\u3002\u5f53\u52a0\u51651,1-\u4e8c\u82ef\u57fa\u4e59\u70ef\u65f6\uff0c\u53cd\u5e94\u4e5f\u88ab\u6291\u5236\uff0c\u4ec5\u83b7\u5f9740\uff05\u6536\u7387\u7684\u4ea7\u72698<\/strong>\uff08Scheme 4c\uff09\u3002\u5728\u81ea\u7531\u57fa\u949f\u5b9e\u9a8c\u4e2d\uff0c\u53cd\u5e94\u4ee532\uff05\u7684\u6536\u7387\u5f62\u6210\u5f00\u73af\u4ea7\u726970<\/strong>\uff0c\u4e14\u672a\u83b7\u5f97\u6c28\u57fa\u53e0\u6c2e\u5316\u4ea7\u726971<\/strong>\uff08Scheme 4d\uff09\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u8be5\u53cd\u5e94\u53ef\u80fd\u6d89\u53ca\u82c4\u57fa\u81ea\u7531\u57fa\u7684\u53c2\u4e0e\u3002\u5176\u6b21\uff0c\u4e3a\u4e86\u786e\u5b9a\u50ac\u5316\u6d3b\u6027\u7269\u8d28\uff0c\u4f5c\u8005\u5408\u6210\u4e86\u4e24\u79cd\u914d\u5408\u7269L2<\/strong>-Fe(II)OTf2<\/sub>\u2022THF\u548cL2<\/strong>-Fe(II)OTf2<\/sub>\u2022CH3<\/sub>CN\uff0c\u53cd\u5e94\u7ed3\u679c\u8868\u660e\uff0cL2<\/strong>-Fe(II)OTf2<\/sub>\u914d\u5408\u7269\u53ef\u4ee5\u7528\u4f5c\u50ac\u5316\u6d3b\u6027\u7269\u8d28\uff08Scheme 4e\uff09\u3002<\/p>\n

\"\"<\/a>\"\"<\/a><\/p>\n

\u6700\u540e\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u4e00\u79cd\u53ef\u80fd\u7684\u53cd\u5e94\u673a\u7406\uff08Scheme 5\uff09\u3002\u9996\u5148\uff0c\u94c1\u50ac\u5316\u5242\u4e0e\u914d\u4f53\u7684\u914d\u4f4d\u5f62\u6210\u94c1(II)\u914d\u5408\u7269\uff08A\uff09\uff0c\u53ef\u4e0eTMSN3\u8fdb\u884c\u914d\u4f53\u4ea4\u6362\uff0c\u5f97\u5230\u53e0\u6c2e\u5316\u94c1(II)\u914d\u5408\u7269\uff08B\uff09\u3002\u7d27\u63a5\u7740\uff0cNFSI\u548cB\u7ecf\u5355\u7535\u5b50\u8f6c\u79fb\u5f62\u6210\u53e0\u6c2e\u5316\u94c1(III)\u914d\u5408\u7269\uff08C\uff09\u548c\u53cc\u78fa\u9170\u80fa\u81ea\u7531\u57fa\uff08D\uff09\u3002\u540c\u65f6\uff0c\u914d\u5408\u7269A\u4e5f\u53ef\u4e0eNFSI\u7ecf\u5355\u7535\u5b50\u8f6c\u79fb\u5f62\u6210\u914d\u5408\u7269E\u548c\u81ea\u7531\u57fa\uff08D\uff09\uff0cE\u4e0eTMSN3\u53cd\u5e94\u751f\u6210\u53e0\u6c2e\u5316\u94c1(III)\u914d\u5408\u7269\uff08C\uff09\u3002\u5c06\u53cc\u78fa\u9170\u80fa\u81ea\u7531\u57fa\u57fa\uff08D\uff09\u4e0e\u82ef\u4e59\u70ef\u8fdb\u884c\u52a0\u6210\u5f62\u6210\u82c4\u57fa\u81ea\u7531\u57fa\uff08F\uff09\u3002\u6700\u540e\uff0c\u82c4\u57fa\u81ea\u7531\u57fa\u53ef\u4e0e\u914d\u5408\u7269C\u7ecf\u57fa\u56e2\u8f6c\u79fb\u673a\u7406\uff0c\u4ece\u800c\u83b7\u5f97\u76ee\u6807\u4ea7\u7269\u5e76\u518d\u751f\u6d3b\u6027\u50ac\u5316\u5242A\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u603b\u7ed3<\/h4>\n

\u4e2d\u79d1\u9662\u798f\u5efa\u7269\u6784\u6240\u9c8d\u7ea2\u4e3d\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u7b2c\u4e00\u4e2a\u94c1\u50ac\u5316\u82ef\u4e59\u70ef\u7684\u4e0d\u5bf9\u79f0\u6c28\u57fa\u53e0\u6c2e\u5316\u548c\u53cc\u53e0\u6c2e\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u5408\u6210\u4e86\u4e00\u7cfb\u5217\u624b\u6027\u80fa\u5316\u6709\u673a\u53e0\u6c2e\u5316\u7269\u548c\u4e8c\u53e0\u6c2e\u5316\u7269\uff0c\u5e76\u53ef\u8fdb\u4e00\u6b65\u8f6c\u5316\u4e3a\u5404\u79cd\u5177\u6709\u4ef7\u503c\u7684\u542b\u6c2e\u5316\u5408\u7269\u3002\u540c\u65f6\uff0c\u8be5\u53cd\u5e94\u5177\u6709\u6e29\u548c\u7684\u53cd\u5e94\u3001\u5e7f\u6cdb\u7684\u5e95\u7269\u8303\u56f4\u3001\u826f\u597d\u7684\u5b98\u80fd\u56e2\u8010\u53d7\u6027\u7b49\u7279\u70b9\u3002\u6b64\u5916\uff0c\u8be5\u53cd\u5e94\u6d89\u53ca\u82c4\u57fa\u81ea\u7531\u57fa\u53c2\u4e0e\u3002<\/p>\n

\u53c2\u8003\u6587\u732e<\/h4>\n[1] X. Shao, K. Li, S. J. Malcolmson, J. Am. Chem. Soc. <\/em>2018<\/strong>, 140<\/em>, 7083-7087.<\/p>\n[2] M. Zhou, K. Li, D. Chen, R. Xu, G. Xu, W. Tang, J. Am. Chem. Soc. <\/em>2020<\/strong>, 142<\/em>, 10337-10342.<\/p>\n[3] a) H. Du, W. Yuan, B. Zhao, Y. Shi, J. Am. Chem. Soc. <\/em>2007<\/strong>, 129<\/em>, 11688-11689; b) H. Du, B. Zhao, Y. Shi, J. Am. Chem. Soc. <\/em>2008<\/strong>, 130<\/em>, 8590-8591; c) H. Du, B. Zhao, W. Yuan, Y. Shi, Org. Lett. <\/em>2008<\/strong>, 10<\/em>, 4231-4234.<\/p>\n[4] X. Hu, Z. Cao, Z. Liu, Y. Wang, H. Du, Adv. Synth. Catal. <\/em>2010<\/strong>, 352<\/em>, 651-655.<\/p>\n[5] M.-S. Wu, T. Fan, S.-S. Chen, Z.-Y. Han, L.-Z. Gong, Org. Lett. <\/em>2018<\/strong>, 20<\/em>, 2485-2489.<\/p>\n[6] K. Muniz, L. Barreiro, R. M. Romero, C. Martinez, J. Am. Chem. Soc. <\/em>2017<\/strong>, 139<\/em>, 4354-4357.<\/p>\n[7] Z. Tao, B. B. Gilbert, S. E. Denmark, J. Am. Chem. Soc. <\/em>2019<\/strong>, 141<\/em>, 19161-19170.<\/p>\n[8] E. L. Ingalls, P. A. Sibbald, W. Kaminsky, F. E. Michael, J. Am. Chem. Soc. <\/em>2013<\/strong>, 135<\/em>, 8854-8856.<\/p>\n[9] a) B. W. Turnpenny, S. R. Chemler, Chem. Sci. <\/em>2014<\/strong>, 5<\/em>, 1786-1793; b) F. C. Sequeira, B. W. Turnpenny, S. R. Chemler, Angew. Chem. Int. Ed. <\/em>2010<\/strong>, 49<\/em>, 6365-6368; Angew<\/em>. Chem<\/em>. Int. Ed.<\/em>2010<\/strong>, 122, 6509 \u20136512.<\/p>\n[10] S. Fu, H. Yang, G. Li, Y. Deng, H. Jiang, W. Zeng, Org. Lett. <\/em>2015<\/strong>, 17<\/em>, 1018-1021.<\/p>\n[11] G. Qiu, Q. Wang, J. Zhu, Org. Lett. <\/em>2017<\/strong>, 19<\/em>, 270-273.<\/p>\n[12] X. Li, X. Qi, C. Hou, P. Chen, G. Liu, Angew. Chem. Int. Ed. <\/em>2020<\/strong>, 59<\/em>, 17239-17244; Angew<\/em>. Chem<\/em>. Int. Ed.<\/em>2020<\/strong>, 132, 17392 \u201317397.<\/p>\n[13] a) X. Huang, T. M. Bergsten, J. T. Groves, J. Am. Chem. Soc. <\/em>2015<\/strong>, 137<\/em>, 5300-5303; b) L. Zhang, S. Liu, Z. Zhao, H. Su, J. Hao, Y. Wang, Chem. Sci. <\/em>2018<\/strong>, 9<\/em>, 6085-6090.<\/p>\n[14] M. F. Chiou, H. Xiong, Y. Li, H. Bao, X. Zhang, Molecules <\/em>2020<\/strong>, 25<\/em>, 1224.<\/p>\n[15] a) B. Chen, C. Fang, P. Liu, J. M. Ready, Angew. Chem. Int. Ed. <\/em>2017<\/strong>, 56<\/em>, 8780-8784; Angew<\/em>. Chem<\/em>. Int. Ed.<\/em>2017<\/strong>, 129, 8906 \u20138910; b) Y. Zeng, M. F. Chiou, X. Zhu, J. Cao, D. Lv, W. Jian, Y. Li, X. Zhang, H. Bao, J. Am. Chem. Soc. <\/em>2020<\/strong>, 142<\/em>, 18014-18021; c) L. Ge, H. Zhou, M.-F. Chiou, H. Jiang, W. Jian, C. Ye, X. Li, X. Zhu, H. Xiong, Y. Li, L. Song, X. Zhang, H. Bao, Nat. Catal. <\/em>2021, <\/strong>4, 28-35; d) L. M. Jin, P. Xu, J. Xie, X. P. Zhang, J. Am. Chem. Soc. <\/em>2020<\/strong>, 142<\/em>, 20828-20836; e) L. Wu, Z. Zhang, D. Wu, F. Wang, P. Chen, Z. Lin, G. Liu, Angew. Chem. Int. Ed. <\/em>2021<\/strong>, 60<\/em>, 6997-7001; Angew<\/em>. Chem<\/em>. Int. Ed.<\/em>2021<\/strong>, 133<\/em>, 7073-7077.<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb \u70ef\u70c3\u7684\u4e0d\u5bf9\u79f0\u6c28\u57fa\u53e0\u6c2e\u5316\uff08aminoazidation\uff09\u548c\u53cc\u53e0\u6c2e\u5316\uff08diazidation\uff09\u662f\u4e00\u7c7b\u6784\u5efa\u624b\u6027\u542b\u6c2e\u5316\u5408\u7269\u7684\u6709\u6548\u7b56\u7565\u3002\u8fd1\u65e5\uff0c\u4e2d\u79d1\u9662\u798f\u5efa\u7269\u6784\u6240\u9c8d\u7ea2\u4e3d\u8bfe\u9898\u7ec4\u5728Angew. Chem. Int. Ed. \u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e86\u94c1\u50ac\u5316\u82ef\u4e59\u70ef\u5206\u5b50\u95f4\u7684\u4e0d\u5bf9\u79f0\u6c28\u57fa\u53e0\u6c2e\u5316\u548c\u53cc\u53e0\u5316\u53cd\u5e94\uff0c\u8be5\u53cd\u5e94\u4ec5\u4f7f\u7528\u8f83\u4f4e\u50ac\u5316\u91cf\u7684\u50ac\u5316\u5242\u548c\u624b\u6027\u914d\u4f53\uff0c\u901a\u8fc7\u81ea\u7531\u57fa\u673a\u7406\u8fdb\u884c\uff0c\u6d89\u53ca\u65e0\u73af\u81ea\u7531\u57fa\u7684\u7acb\u4f53\u63a7\u5236\uff08\u53ef\u80fd\u901a\u8fc7\u57fa\u56e2\u8f6c\u79fb\u8fc7\u7a0b\uff09\u3002 Iron-Catalyzed Radical Asymmetric Aminoazidation and Diazidation of Styrenes Hongli Bao, Daqi Lv, Qiao Sun, Huan Zhou, Liang Ge, Yanjie Qu, Taian Li, Xiaoxu Ma, and Yajun Li Angew. Chem. Int. Ed. ASAP DOI: 10.1002\/anie.202017175 \u6b63\u6587 \u5bf9\u6620\u4f53\u5bcc\u96c6\u7684\u90bb\u4e8c\u80fa\u5316\u5408\u7269\u5e7f\u6cdb\u7684\u5b58\u5728\u4e8e\u5929\u7136\u4ea7\u7269\u3001\u836f\u7269\u548c\u751f\u7269\u6d3b\u6027\u5206\u5b50\u4e2d\uff0c\u4e5f\u53ef\u4f5c\u4e3a\u624b\u6027\u914d\u4f53\u53c2\u4e0e\u4e0d\u5bf9\u79f0\u50ac\u5316\u3002\u867d\u7136\u53ef\u901a\u8fc7\u919b\u4e9a\u80fa[1]\u548c\/\u6216\u4e9a\u80fa[2]\u8fd8\u539f\u5076\u8054\u5408\u6210\u624b\u6027\u4e8c\u80fa\u5316\u5408\u7269\uff0c\u4f46\u70ef\u70c3\u6216\u4e8c\u70ef\u7684\u50ac\u5316\u4e0d\u5bf9\u79f0\u80fa\u5316\u53cd\u5e94\u4f5c\u4e3a\u6700\u76f4\u63a5\u4e14\u4fbf\u6377\u7684\u65b9\u6cd5\uff08Scheme 1\uff09\uff0c\u66f4\u52a0\u53d7\u5230\u79d1\u5b66\u5bb6\u4eec\u7684\u5173\u6ce8\u3002\u5982Shi[3]\u3001Du[4]\u3001Gong[5]\u3001Mu\u00f1iz[6]\u548cDenmark[7]\u7b49\u5206\u522b\u62a5\u9053\u4e86\u94af\u3001\u7898\u3001\u6709\u673a\u7852\u50ac\u5316\u7b49\u50ac\u5316\u70ef\u70c3\u6216\u4e8c\u70ef\u7684\u5206\u5b50\u95f4\u4e8c\u80fa\u5316\u53cd\u5e94\u3002Michael[8]\u3001Chemler[9]\u3001Zeng[10]\u548cLiu[11] \u4e5f\u62a5\u9053\u4e86\u901a\u8fc7\u4e00\u79cd\u5916\u90e8\u80fa\u5316\u8bd5\u5242\u548c\u70ef\u70c3\u884d\u751f\u7684\u5e95\u7269\uff0c\u7ecf\u94af\u6216\u94dc\u50ac\u5316\u5b9e\u73b0\u5206\u5b50\u95f4\/\u5185\u7684\u4e8c\u80fa\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u5408\u6210\u624b\u6027\u5432\u54da\u548c\u5421\u54af\u70f7\u5316\u5408\u7269\u3002\u8fd9\u5176\u4e2d\u70ef\u70c3\u7684\u6c28\u57fa\u53e0\u6c2e\u5316\u548c\u53cc\u53e0\u6c2e\u5316\u53ef\u4f5c\u4e3a\u4e92\u8865\u7684\u65b9\u6cd5\u6765\u5408\u6210\u90bb\u4e8c\u80fa\u5316\u5408\u7269\u3002\u6b64\u5916\uff0c\u6709\u673a\u53e0\u6c2e\u5316\u7269\u4e5f\u4f5c\u4e3a\u4e00\u79cd\u901a\u7528\u53cd\u5e94\u5e95\u7269\uff0c\u53ef\u8fdb\u884c\u591a\u79cd\u53cd\u5e94\uff0c\u5982Curtius\u91cd\u6392\u3001Regitz\u91cd\u6c2e\u8f6c\u79fb\u3001Aza-Wittig\u53cd\u5e94\u3001Boyer\u91cd\u6392\u7b49\u3002\u76ee\u524d\u6587\u732e\u4e2d[12]\u4ec5\u6709\u4e00\u4f8b\u5173\u4e8e\u5e94\u7528\u4e0d\u5bf9\u79f0\u6c28\u57fa\u53e0\u6c2e\u5316\u53cd\u5e94\u6765\u5408\u6210\u4e0d\u540c\u7684\u53d6\u4ee3\u54cc\u5576\u7684\u5b9e\u4f8b\uff08Scheme 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[15a]\u3001Zhang\u7b49\u62a5\u9053\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5206\u5b50\u95f4\u81ea\u7531\u57faC-H\u80fa\u5316\u53cd\u5e94[15d]\u4ee5\u53ca\u672c\u8bfe\u9898\u7ec4[15c]\u548cLiu[15e]\u62a5\u9053\u7684\u82ef\u4e59\u70ef\u548c\u4e19\u70ef\u9170\u80fa\u7684\u4e0d\u5bf9\u79f0\u78b3\u53e0\u6c2e\u5316\u53cd\u5e94\u7684\u542f\u53d1\uff0c\u5728\u6b64\uff0c\u672c\u8bfe\u9898\u7ec4\u5c06\u8fdb\u4e00\u6b65\u62a5\u9053\u4e00\u79cd\u94c1\u50ac\u5316\u82ef\u4e59\u70ef\u7684\u4e0d\u5bf9\u79f0\u6c28\u57fa\u53e0\u6c2e\u5316\u548c\u53cc\u53e0\u6c2e\u5316\u53cd\u5e94\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u4ee5\u82ef\u4e59\u70ef1a\u3001NFSI\uff08\u6c2e\u81ea\u7531\u57fa\u524d\u4f53\uff09\u548cTMSN3\uff08\u53e0\u6c2e\u6e90\uff09\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u4e86\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u7b5b\u9009\uff08Table 1\uff09\u3002\u53cd\u5e94\u7684\u6700\u4f73\u6761\u4ef6\u4e3a\uff1a\u4ee5Fe(OTf)2 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Shao, K. Li, S. J. Malcolmson, J. Am. Chem. Soc. 2018, 140, 7083-7087. [2] M. Zhou, K. Li, D. Chen, R. Xu, G. Xu, W. Tang, J. Am. Chem. Soc. 2020, 142, 10337-10342. [3] a) H. 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