{"id":37996,"date":"2021-04-08T08:00:11","date_gmt":"2021-04-08T00:00:11","guid":{"rendered":"\/\/www.gsbet888.com\/?p=37996"},"modified":"2021-04-06T16:37:40","modified_gmt":"2021-04-06T08:37:40","slug":"%e4%b8%ad%e5%9b%bd%e7%a7%91%e5%ad%a6%e9%99%a2%e5%b9%bf%e5%b7%9e%e7%94%9f%e7%89%a9%e5%8c%bb%e8%8d%af%e4%b8%8e%e5%81%a5%e5%ba%b7%e7%a0%94%e7%a9%b6%e9%99%a2%e6%9c%b1%e5%bc%ba%e8%af%be%e9%a2%98%e7%bb%84ja","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2021\/04\/%e4%b8%ad%e5%9b%bd%e7%a7%91%e5%ad%a6%e9%99%a2%e5%b9%bf%e5%b7%9e%e7%94%9f%e7%89%a9%e5%8c%bb%e8%8d%af%e4%b8%8e%e5%81%a5%e5%ba%b7%e7%a0%94%e7%a9%b6%e9%99%a2%e6%9c%b1%e5%bc%ba%e8%af%be%e9%a2%98%e7%bb%84ja.html","title":{"rendered":"\u4e2d\u56fd\u79d1\u5b66\u9662\u5e7f\u5dde\u751f\u7269\u533b\u836f\u4e0e\u5065\u5eb7\u7814\u7a76\u9662\u6731\u5f3a\u8bfe\u9898\u7ec4JACS\uff1a \u8f74\u624b\u60272-\u82b3\u57fa\u548c2,3-\u4e8c\u82b3\u57fa\u55b9\u5511\u5549\u916e\u7684\u5408\u6210\uff08\u963b\u8f6c\u9009\u62e9\u6027\uff09"},"content":{"rendered":"

\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749<\/strong><\/p>\n

\u5bfc\u8bfb<\/h4>\n

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Palladium-Catalyzed Atroposelective Coupling-Cyclization of\u00a02\u2011Isocyanobenzamides to Construct Axially Chiral 2\u2011Aryl-\u00a0and 2,3-Diarylquinazolinones<\/p>\n

Fan Teng, Ting Yu, Yan Peng, Weiming Hu, Huaanzi Hu, Yimiao He, Shuang Luo,* and Qiang Zhu*<\/p>\n

J.Am. Chem. Soc.<\/em>ASAPDOI:<\/span>10.1021\/jacs.1c00640<\/u><\/a><\/p><\/blockquote>\n

\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

\u603b\u7ed3<\/h4>\n

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\u53c2\u8003\u6587\u732e<\/h4>\n[1]\u00a0Tian, M.; Bai, D.; Zheng, G.; Chang, J.; Li, X. Rh(III)-Catalyzed Asymmetric Synthesis of Axially Chiral Biindolyls by\u00a0Merging C\u2212H Activation and Nucleophilic Cyclization. J. Am. Chem.<\/em>\u00a0<\/em>Soc. <\/em>2019<\/strong>, 141, 9527\u22129532.<\/p>\n[2]\u00a0Peng, C.; Kusakabe, T.; Kikkawa, S.;\u00a0Mochida, T.; Azumaya, I.; Dhage, Y. D.; Takahashi, K.; Sasai, H.;\u00a0Kato, K. Asymmetric Cyclizative Dimerization of (ortho-Alkynyl\u00a0Phenyl) (Methoxymethyl) Sulfides with Palladium(II) Bisoxazoline\u00a0Catalyst.\u00a0Chem. – Eur. J. <\/em>2019<\/strong>, 25, 733\u2212737.<\/p>\n[3] Diener, M. E.; Metrano, A. J.; Kusano, S.; Miller, S. J.\u00a0Enantioselective Synthesis of 3-Arylquinazolin-4(3H)-ones via Peptide-Catalyzed AtroposelectiveBromination. J. Am. Chem. Soc.<\/em>\u00a02015<\/strong>,\u00a0137, 12369\u221212377.<\/p>\n[4]\u00a0Hirai, M.; Terada, S.; Yoshida, H.; Ebine, K.; Hirata, T.;\u00a0Kitagawa, O. Catalytic Enantioselective Synthesis of N\u2212C Axially\u00a0Chiral Mebroqualone and Its Derivatives through Reductive\u00a0Asymmetric Desymmetrization. Org. Lett.<\/em>\u00a02016<\/strong>, 18, 5700\u22125703.<\/p>\n[5] Wang, Y. B.; Zheng, S. C.; Hu, Y. M.; Tan, B. Br\u00f8nstedacidcatalysed\u00a0enantioselective construction of axially chiral arylquinazolinones.\u00a0Nat. Commun. <\/em>2017<\/strong>, 8, 15489.<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb \u8fd1\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5e7f\u5dde\u751f\u7269\u533b\u836f\u4e0e\u5065\u5eb7\u7814\u7a76\u9662\u6731\u5f3a\u8bfe\u9898\u7ec4\u5728J. Am. Chem. Soc.\u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e86\u4e00\u79cd\u94af\u50ac\u5316N-\u70f7\u57fa-2-\u5f02\u6c30\u57fa\u82ef\u7532\u9170\u80fa\u4e0e2,6-\u4e8c\u53d6\u4ee3\u82b3\u57fa\u7898\u5316\u7269\u7684\u73af\u9170\u80fa\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u83b7\u5f97\u8f74\u624b\u60272-\u82b3\u57fa\u55b9\u5511\u5549\u916e\u884d\u751f\u7269\uff0c\u5177\u6709\u826f\u597d\u7684\u6536\u7387\u548c\u963b\u8f6c\u9009\u62e9\u6027\u3002\u540c\u65f6\uff0c\u5f53\u4ee5N-\uff082,4-\u4e8c\u7532\u6c27\u57fa\u82ef\u57fa\uff09-2-\u5f02\u6c30\u57fa\u82ef\u7532\u9170\u80fa\u4f5c\u5e95\u7269\u65f6\uff0c\u4f1a\u4ea7\u751f\u5177\u6709\u4e24\u4e2a\u7acb\u4f53\u5f02\u6784\u8f74\u76842,3-\u4e8c\u82b3\u57fa\u55b9\u5511\u5549\u916e\uff0c\u5177\u6709\u4e2d\u7b49\u7684\u975e\u5bf9\u6620\u9009\u62e9\u6027\u548c\u826f\u597d\u7684\u5bf9\u6620\u9009\u62e9\u6027\u3002\u5176\u4e2d\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5e7f\u5dde\u751f\u7269\u533b\u836f\u4e0e\u5065\u5eb7\u7814\u7a76\u9662\u6731\u5f3a\u548c\u7f57\u723d\u4e3a\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002 Palladium-Catalyzed Atroposelective Coupling-Cyclization of\u00a02\u2011Isocyanobenzamides to Construct Axially Chiral 2\u2011Aryl-\u00a0and 2,3-Diarylquinazolinones Fan Teng, Ting Yu, Yan Peng, Weiming Hu, Huaanzi Hu, Yimiao He, Shuang Luo,* and Qiang Zhu* J.Am. Chem. 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Rh(III)-Catalyzed Asymmetric Synthesis of Axially Chiral Biindolyls by\u00a0Merging C\u2212H Activation and Nucleophilic Cyclization. J. Am. Chem.\u00a0Soc. 2019, 141, 9527\u22129532. [2]\u00a0Peng, C.; Kusakabe, T.; Kikkawa, S.;\u00a0Mochida, T.; Azumaya, I.; Dhage, Y. D.; Takahashi, K.; Sasai, H.;\u00a0Kato, K. 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