{"id":38819,"date":"2021-06-04T08:00:42","date_gmt":"2021-06-04T00:00:42","guid":{"rendered":"\/\/www.gsbet888.com\/?p=38819"},"modified":"2021-06-30T15:27:16","modified_gmt":"2021-06-30T07:27:16","slug":"%e7%a7%a6%e5%8b%87","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/interview\/cchemist\/2021\/06\/%e7%a7%a6%e5%8b%87.html","title":{"rendered":"\u79e6\u52c7\u6559\u6388"},"content":{"rendered":"

\u672c\u6587\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a<\/strong><\/p>\n

\u6982\u8981<\/strong><\/h4>\n

\u79e6\u52c7\uff1a\u56db\u5ddd\u5927\u5b66\u534e\u897f\u836f\u5b66\u9662\u9662\u957f\uff0c\u5929\u7136\u836f\u7269\u7cfb\u6559\u6388\uff0c\u836f\u7269\u5316\u5b66\u5bb6<\/p>\n

\u8bfe\u9898\u7ec4\u4e3b\u9875\uff1ahttp:\/\/www.scu-yongqingroup.com\/<\/u><\/a><\/p>\n

\u7ecf\u5386<\/strong><\/h4>\n

1989\u5e74 \u4e91\u5357\u5927\u5b66\uff0c\u5b66\u58eb\u5b66\u4f4d<\/p>\n

1992\u5e74 \u6210\u90fd\u6709\u673a\u5316\u5b66\u7814\u7a76\u6240\uff0c\u7855\u58eb\u5b66\u4f4d<\/p>\n

1995\u5e74 \u4e2d\u79d1\u9662\u5316\u5b66\u7814\u7a76\u6240\uff0c\u535a\u58eb\u5b66\u4f4d\uff08\u5e08\u4ece\u9ec4\u5fd7\u9557\u9662\u58eb\u4e0e\u848b\u8000\u5fe0\u7814\u7a76\u5458\uff09<\/p>\n

1995-1996\u5e74 \u6210\u90fd\u6709\u673a\u5316\u5b66\u7814\u7a76\u6240\u4efb\u52a9\u7406\u7814\u7a76\u5458\uff0c\u526f\u7814\u7a76\u5458<\/p>\n

1996-2000\u5e74 \u00a0The University of Vermont, <\/i><\/em>\u5316\u5b66\u7cfb\u535a\u58eb\u540e<\/p>\n

2000-2003\u5e74 \u7f8e\u56fdSan Diego\u9ad8\u6280\u672f\u751f\u7269\u5236\u836f\u516c\u53f8(Triad Therapeutics Inc.<\/i><\/em>)\uff0c\u4efb\u7814\u7a76\u79d1\u5b66\u5bb6<\/p>\n

2003-\u56db\u5ddd\u5927\u5b66\u534e\u897f\u836f\u5b66\u9662\u6559\u6388<\/p>\n

\u83b7\u5956<\/strong>\u7ecf\u5386<\/strong><\/h4>\n

2004\u5e74\u56db\u5ddd\u7701\u6770\u51fa\u9752\u5e74\uff1b<\/p>\n

2005\u5e74\u56db\u5ddd\u7701\u9752\u5e74\u79d1\u6280\u5956\uff1b<\/p>\n

2009\u5e74\u65b0\u4e16\u7eaa\u767e\u5343\u4e07\u4eba\u624d\u5de5\u7a0b\u56fd\u5bb6\u7ea7\u4eba\u9009\uff1b<\/p>\n

2009\u5e74\u4eab\u53d7\u56fd\u52a1\u9662\u7279\u6b8a\u6d25\u8d34\u4e13\u5bb6\uff1b<\/p>\n

2009\u5e74\u8bc4\u4e3a\u6210\u90fd\u5e02\u6709\u7a81\u51fa\u8d21\u732e\u7684\u4f18\u79c0\u4e13\u5bb6\uff1b<\/p>\n

2010\u5e74\u7b2c\u516b\u6279\u56db\u5ddd\u7701\u5b66\u672f\u548c\u6280\u672f\u5e26\u5934\u4eba\uff1b<\/p>\n

2010\u5e74\u83b7\u6559\u80b2\u90e8\u767e\u7bc7\u5168\u56fd\u4f18\u79c0\u535a\u58eb\u5b66\u4f4d\u8bba\u6587\u6307\u5bfc\u6559\u5e08\uff1b<\/p>\n

2013\u5e74\u83b7\u9996\u5c4a\u4e2d\u56fd\u5316\u5b66\u4f1a”\u7ef4\u5584\u5929\u7136\u4ea7\u7269\u5408\u6210\u5956”\uff1b<\/p>\n

2016\u5e74\u83b7\u4e2d\u56fd\u56fd\u5bb6\u77e5\u8bc6\u4ea7\u6743\u5c40\u7b2c\u5341\u516b\u5c4a\u4e2d\u56fd\u4e13\u5229\u5956\u4f18\u79c0\u5956\uff1b<\/p>\n

2017\u5e74\u83b7\u6559\u80b2\u90e8\u81ea\u7136\u79d1\u5b66\u5956\u4e00\u7b49\u5956\uff1b<\/p>\n

2017\u5e74\u56db\u5ddd\u7701\u536b\u751f\u8ba1\u751f\u9996\u5e2d\u4e13\u5bb6\uff1b<\/p>\n

2018\u5e74\u83b7\u7b2c\u4e09\u5c4a\u4e2d\u56fd\u836f\u5b66\u4f1a\u2012\u4ee5\u5cad\u751f\u7269\u533b\u836f\u521b\u65b0\u5956\uff1b<\/p>\n

2019\u5e74\u83b7\u7b2c\u4e8c\u5341\u5c4a\u5434\u9636\u5e73-\u4fdd\u7f57\u6768\u68ee\u533b\u5b66\u836f\u5b66\u5956(\u5434\u6768\u5956)\u3002<\/p>\n

\u7814\u7a76<\/strong>\u65b9\u5411<\/strong><\/h4>\n

\u79e6\u52c7\u6559\u6388\u76ee\u524d\u4e3b\u8981\u4ece\u4e8b\u5177\u6709\u91cd\u8981\u751f\u7406\u6d3b\u6027\u7684\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210\u53ca\u836f\u7269\u5316\u5b66\u7814\u7a76\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u590d\u6742\u751f\u7406\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210<\/strong><\/h4>\n

\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u662f\u6765\u81ea\u5927\u81ea\u7136\u5bf9\u4eba\u7c7b\u7684\u6311\u6218\u4e0e\u673a\u9047\u3002\u4ece\u7b80\u5355\u5230\u590d\u6742\uff0c\u81ea\u4eba\u7c7b\u9996\u6b21\u4ece\u81ea\u7136\u754c\u4e2d\u5206\u79bb\u51fa\u5929\u7136\u4ea7\u7269\u4e4b\u540e\uff0c\u79d1\u5b66\u5bb6\u4fbf\u4e00\u76f4\u4e0d\u65ad\u5730\u5c1d\u8bd5\u5f00\u53d1\u4e00\u7cfb\u5217\u4eba\u5de5\u5408\u6210\u5929\u7136\u4ea7\u7269\u7684\u65b0\u65b9\u6cd5\uff0c\u4ece\u5c0f\u5206\u5b50\u5230\u5927\u5206\u5b50\uff0c\u79d1\u5b66\u5bb6\u4eec\u5728\u5929\u7136\u4ea7\u7269\u5408\u6210\u7684\u7814\u7a76\u4e2d\u9010\u6e10\u524d\u884c\u3002\u79e6\u52c7\u6559\u6388\u8bfe\u9898\u7ec4\u9488\u5bf9\u590d\u6742\u5929\u7136\u4ea7\u7269\u5408\u6210\u9886\u57df\u4e2d\u9ad8\u6548\u6784\u5efa\u5929\u7136\u4ea7\u7269\u9aa8\u67b6\u7684\u6838\u5fc3\u95ee\u9898\u8fdb\u884c\u6df1\u5165\u7814\u7a76\uff0c\u81f4\u529b\u4e8e\u53d1\u5c55\u76f8\u5173\u7684\u521b\u65b0\u5408\u6210\u7b56\u7565\uff0c\u8fdb\u800c\u4fc3\u8fdb\u5404\u7c7b\u751f\u7406\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5728\u751f\u7269\u5b66\u4e0e\u836f\u7269\u7814\u7a76\u65b9\u9762\u7684\u5e94\u7528\uff0c\u4e3a\u521b\u65b0\u836f\u7269\u7684\u7814\u7a76\u63d0\u4f9b\u5148\u5bfc\u5316\u5408\u7269\u3002\u76ee\u524d\uff0c\u79e6\u52c7\u6559\u6388\u5f00\u53d1\u7684 (Cyclopropanation\/Ring-opening\/Iminium cyclization)\u00a0\u73af\u4e19\u70f7\u5316-\u5f00\u73af-\u4e9a\u80fa\u73af\u5408\u7684\u4e32\u8054\u53cd\u5e94\u4e0e\uff08Nitrogen Radical Cascade Reactions\uff09\u6c2e\u81ea\u7531\u57fa\u4e32\u8054\u53cd\u5e94\u4e3a\u4ee3\u8868\u7684\u521b\u65b0\u5408\u6210\u7b56\u7565\u4e0e\u65b9\u6cd5\uff0c\u6210\u529f\u5b9e\u73b0\u90e8\u5206\u5929\u7136\u4ea7\u7269\u7684\u89c4\u6a21\u5316\u5236\u5907\uff0c\u5e76\u5b8c\u6210\u4e86\u7ed3\u6784\u6700\u4e3a\u590d\u6742\u7684\u4ee5\u5432\u54da\u751f\u7269\u78b1\u4e0e\u4e8c\u841c\u751f\u7269\u78b1\u4e3a\u4ee3\u8868\u768470\u591a\u79cd\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210\uff0c\u5176\u4e2d21\u4e2d\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210\u4e3a\u56fd\u9645\u4e0a\u7684\u9996\u6b21\u5408\u6210\uff0c\u90e8\u5206\u7814\u7a76\u5de5\u4f5c\u88ab\u8bc4\u4e3a\u5168\u5408\u6210\u9886\u57df\u4e2d\u7684\u7a81\u7834\u6027\u8fdb\u5c55\u3002<\/p>\n

1.\u57fa\u4e8e\u73af\u4e19\u70f7\u5316-\u5f00\u73af-\u4e9a\u80fa\u73af\u5408\u7684\u4e32\u8054\u53cd\u5e94\u7b56\u7565\u7684\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210<\/b><\/strong><\/p>\n

\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\uff0c\u7279\u522b\u662f\u590d\u6742\u5929\u7136\u4ea7\u7269\u5206\u5b50\u7684\u5168\u5408\u6210\uff0c\u4e00\u76f4\u662f\u5206\u5b50\u7ea7\u522b\u201c\u5efa\u7b51\u8bbe\u8ba1\u5e08\u201d\u7684\u5168\u5408\u6210\u5316\u5b66\u5bb6\u6240\u8ffd\u6c42\u7684\u76ee\u6807\u3002Indoline alkaloids\u662f\u5927\u81ea\u7136\u7ed9\u4e88\u4eba\u7c7b\u7684\u6700\u597d\u9988\u8d60\u3002\u5432\u54da\u5549\u751f\u7269\u78b1\u662f\u5929\u7136\u4ea7\u7269\u4e2d\u7684\u4e00\u4e2a\u5927\u7c7b\uff0c\u7531\u4e8e\u8be5\u7c7b\u5316\u5408\u7269\u591a\u6837\u800c\u590d\u6742\u7684\u7ed3\u6784\uff0c\u4f7f\u5176\u5177\u6709\u8f83\u9ad8\u7684\u751f\u7269\u6d3b\u6027\uff0c\u5e76\u5728\u6297\u80bf\u7624\u3001\u764c\u75c7\u4ee5\u53ca\u5176\u4ed6\u75be\u75c5\u4e2d\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u6548\u679c\u3002Qin\u8bfe\u9898\u7ec4\u81f4\u529b\u4e8e\u53d1\u5c55\u521b\u65b0\u5408\u6210\u7b56\u7565\uff0c\u6784\u5efa\u4e0d\u540c\u7ed3\u6784\u7684\u5432\u54da\u5549\u751f\u7269\u78b1\uff0c\u8fdb\u800c\u4fc3\u8fdb\u5728\u751f\u7269\u5b66\u4e0e\u836f\u7269\u7814\u7a76\u65b9\u9762\u7684\u5e94\u7528\uff0c\u4e3a\u521b\u65b0\u836f\u7269\u7684\u7814\u7a76\u63d0\u4f9b\u5148\u5bfc\u5316\u5408\u7269\u3002\u79e6\u52c7\u6559\u6388\u5c0f\u7ec4\u9009\u62e9\u5177\u6709\u91cd\u8981\u836f\u7528\u4ef7\u503c\u7684\u5432\u54da\u751f\u7269\u78b1\u4f5c\u4e3a\u7814\u7a76\u5bf9\u8c61\uff0c\u539f\u521b\u6027\u5730\u53d1\u5c55\u4e86\u4e00\u79cd\u57fa\u4e8eIndoline alkaloids\u9aa8\u67b6\u4e2d\u8272\u80fa\u57fa\u56e2\u7684\u73af\u4e19\u70f7\u5316-\u5f00\u73af-\u4e9a\u80fa\u73af\u5408\u7684\u4e32\u8054\u53cd\u5e94(cyclopropanation\/ring-opening\/iminium cyclization)\uff08CRI\u53cd\u5e94\uff09\uff0c\u6210\u529f\u5730\u5efa\u7acb\u4e94\u79cd\u590d\u6742\u5432\u54da\u751f\u7269\u78b1\u9aa8\u67b6\uff08Type I-Type V\uff09\u7684\u901a\u7528\u6784\u5efa\u65b9\u6cd51-6<\/sup>\u3002\u540c\u65f6\uff0cQin\u5c0f\u7ec4\u8fdb\u4e00\u6b65\u5e94\u7528\u8fd9\u4e00\u7b56\u7565\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u4e00\u7cfb\u5217\u590d\u6742\u5432\u54da\u751f\u7269\u78b1\u7684\u5168\u5408\u6210\uff08Fig. 1\uff09\u3002<\/p>\n

\"\"<\/a><\/p>\n

Fig. 1\u57fa\u4e8e\u73af\u4e19\u70f7\u5316-\u5f00\u73af-\u4e9a\u80fa\u73af\u5408\u7684\u4e32\u8054\u53cd\u5e94\u7b56\u7565\u7684\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210<\/p>\n

2.\u57fa\u4e8e\u53ef\u89c1\u5149\u50ac\u5316\u4ea7\u751f\u6c2e\u81ea\u7531\u57fa\u7b56\u7565\u7684\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210<\/b><\/strong><\/p>\n

Monoterpene indole alkaloids, \u5305\u542b3000\u591a\u79cd\u5df2\u77e5\u6210\u5458\u4e0e40\u591a\u79cd\u4e0d\u540c\u7684\u7ed3\u6784\u7c7b\u578b\uff0c\u662f\u6700\u5927\u7684\u5929\u7136\u4ea7\u7269\u5bb6\u65cf\u4e4b\u4e00\uff0c\u540c\u65f6\uff0c\u4e5f\u662f\u662f\u91cd\u8981\u7684\u836f\u7269\u6765\u6e90\u3002\u6570\u5341\u5e74\u6765\uff0c\u5176\u590d\u6742\u7684\u5316\u5b66\u7ed3\u6784\u4e0e\u4f18\u826f\u7684\u751f\u7269\u5b66\u6d3b\u6027\uff0c\u4f7f\u8fd9\u7c7b\u751f\u7269\u78b1\u6210\u4e3a\u201c\u5929\u7136\u4ea7\u7269\u5efa\u7b51\u5e08\u201d\u773c\u4e2d\u6700\u6709\u5438\u5f15\u529b\u7684\u7ed3\u6784\u5355\u5143\u3002\u5c3d\u7ba1\u5316\u5b66\u5bb6\u00a0\u4e3aMonoterpene indole alkaloids,\u7684\u5408\u6210\u53d1\u5c55\u8bb8\u591a\u7684\u5408\u6210\u65b9\u6cd5\u4e0e\u7b56\u7565\uff0c\u7136\u800c\uff0c\u53d1\u5c55\u4e00\u79cd\u5bf9\u4e8e\u4e00\u7cfb\u5217\u4e0d\u540c\u7ed3\u6784\u7c7b\u578b\u7684\u5355\u841c\u5432\u54da\u751f\u7269\u78b1\u7684\u5168\u5408\u6210\u66f4\u4e3a\u901a\u7528\u7684\u7b56\u7565\uff0c\u4ecd\u7136\u5b58\u5728\u8f83\u5927\u7684\u6311\u6218\u3002\u8fd1\u5e74\u6765\uff0c\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u5df2\u7ecf\u6210\u4e3a\u4e00\u79cd\u5f3a\u6709\u529b\u7684\u5de5\u5177\uff0c\u53ef\u4ee5\u901a\u8fc7\u5355\u7535\u5b50\u8f6c\u79fb\uff08SET\uff09\u8fc7\u7a0b\u5b9e\u73b0\u4e00\u7cfb\u5217\u76f8\u5e94\u7684\u5408\u6210\u8f6c\u5316\uff0c\u79e6\u52c7\u6559\u6388\u5c0f\u7ec4\u5c06\u5149\u50ac\u5316\u5e94\u7528\u4e0e\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u4e2d\uff0c\u521b\u65b0\u6027\u5730\u53d1\u5c55\u4e86\u4e00\u79cd\u5728\u53ef\u89c1\u5149\u50ac\u5316\u6761\u4ef6\u4e0b\uff0c\u901a\u8fc7\u53bb\u8d28\u5b50\u5316\u4e0e\u6c27\u5316\u8fc7\u7a0b\uff0c\u5c06\u82ef\u80faN-H\u5b98\u80fd\u56e2\u8f6c\u5316\u4e3a\u6c2e\u81ea\u7531\u57fa\uff0c\u8fdb\u800c\u901a\u8fc7\u5206\u5b50\u5185\u52a0\u6210\u7684\u65b9\u5f0f\uff0c\u987a\u5229\u5c06\u8fd9\u79cd\u7f3a\u7535\u5b50\u7684\u6c2e\u81ea\u7531\u57fa\u5f15\u5165\u81f3\u5bcc\u7535\u5b50\u7684\u70ef\u80fa\u5355\u5143\u7684\u03b2-\u78b3\u539f\u5b50\u4e2d\uff0c\u5e76\u8fdb\u4e00\u6b65\u5f15\u53d1\u5206\u5b50\u5185\/\u5206\u5b50\u5185\u3001\u5206\u5b50\u5185\/\u5206\u5b50\u95f4\u4ee5\u53ca\u5206\u5b50\u5185\/\u5206\u5b50\u95f4\/\u5206\u5b50\u5185\u7684\u4e09\u79cd\u7c7b\u578b\u7684\u81ea\u7531\u57fa\u4e32\u8054\u53cd\u5e947-9<\/sup>\uff08Fig. 2 \uff09\uff0c\u4e00\u9505\u591a\u6b65\u5730\u5b9e\u73b0\u5982\u4e0b\u56fe\u6240\u793a\u7684\u767d\u575a\u6728\u578b\uff08Type I\uff09\u00a0(Aspidosperma (type I))\u3001\u56db\u6c22\u5494\u6ce2\u5549\u578b\uff08Type II\uff09(tetrahydrocarbolinone (type II))\u548c\u67ef\u6960\u56e0\u578b\uff08Type III\uff09(Corynanthe (type III))\u4e09\u79cd\u5b98\u80fd\u5316\u7684\u624b\u6027\u5355\u841c\u5432\u54da\u751f\u7269\u78b1\u9aa8\u67b6\u7684\u9ad8\u6548\u5408\u6210\u3002\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u8fd0\u7528\u4e0a\u8ff0\u7b56\u7565\uff0c\u6700\u7ec8\u5b9e\u73b0\u4e8633\u4e2a\u5206\u5c5e\u4e8e\u56db\u4e2a\u4e0d\u540c\u5bb6\u65cf\u7684\u5355\u841c\u5432\u54da\u751f\u7269\u78b1\u7684\u9ad8\u6548\u96c6\u7fa4\u5f0f\u5408\u6210(\u00a0Collective Total Synthesis)\uff08\u56fe3\uff09\u3002<\/p>\n

\"\"<\/a><\/p>\n

Fig. 2 \u53ef\u89c1\u5149\u50ac\u5316\u4ea7\u751f\u6c2e\u81ea\u7531\u57fa\u7b56\u7565<\/p>\n

\"\"<\/a><\/p>\n

Fig. 3 \u5355\u841c\u5432\u54da\u751f\u7269\u78b1\u7684\u9ad8\u6548\u96c6\u7fa4\u5f0f\u5408\u6210<\/p>\n

3.\u4e8c\u841c\u751f\u7269\u78b1\u7684\u5168\u5408\u6210<\/b><\/strong><\/p>\n

\u4e09\u7ef4\u7b3c\u72b6\u5929\u7136\u4ea7\u7269(Three-dimensional cage-like natural products)\u662f\u5168\u5408\u6210\u7814\u7a76\u4e2d\u7684\u957f\u671f\u6311\u6218\u4e4b\u4e00\u3002\u4f5c\u4e3a\u4e4c\u5934\u5c5e(Aconitum)\u548c\u98de\u71d5\u8349(Delphinium)\u5c5e\u690d\u7269\u7684\u7279\u5f81\u6210\u5206\uff0c\u8fd9\u4e9b\u5206\u5b50\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u751f\u7269\u6d3b\u6027\uff0c\u5176\u4e2d\u4e00\u4e9b\u5df2\u7ecf\u7528\u4f5c\u4e34\u5e8a\u836f\u7269\u3002\u66f4\u5f15\u4eba\u6ce8\u76ee\u7684\u662f\uff0c\u5b83\u4eec\u590d\u6742\u800c\u7f8e\u4e3d\u7684\u7ed3\u6784\u4f7f\u5f97\u4e8c\u841c\u751f\u7269\u78b1\u6210\u4e3a\u201c\u5929\u7136\u4ea7\u7269\u5efa\u7b51\u5e08\u201d\u773c\u4e2d\u7684\u8c61\u7259\u5854\u3002\u79e6\u52c7\u6559\u6388\u5c0f\u7ec4\u9488\u5bf9\u5177\u6709\u590d\u6742\u7ed3\u6784\u4e0e\u5e7f\u6cdb\u751f\u7406\u6d3b\u6027\u7684\u4e8c\u841c\u751f\u7269\u78b1\u7c7b\u5929\u7136\u4ea7\u7269\uff0c\u7cfb\u7edf\u6027\u5730\u91c7\u7528\u6c27\u5316\u53bb\u82b3\u9999\u5316\/Diels-Alder\u73af\u52a0\u6210\u4f5c\u4e3a\u5173\u952e\u7684\u53cd\u5e94\u7b56\u7565\uff0c\u6210\u529f\u7684\u6784\u5efa\u8d77\u76ee\u6807\u5206\u5b50\u4e2d\u666e\u904d\u5b58\u5728\u7684[2.2.2]\u53cc\u73af\u5355\u5143\u53ca\u5176\u76f8\u5173\u7684\u73af\u626d\u66f2\u884d\u751f\u7269\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u591a\u79cd\u6e90\u4e8e\u4e4c\u5934\u5c5e(Aconitum)\u7684\u4e8c\u841c\u751f\u7269\u78b1 (Diterpenoid alkaloids)\u53ca\u76f8\u5e94\u7684\u4e8c\u841c\u5206\u5b50\u7684\u5168\u5408\u621010-14<\/sup>\u3002\u76ee\u524d\uff0c\u79e6\u52c7\u6559\u6388\u5c0f\u7ec4\u5df2\u7ecf\u5b9e\u73b0\u4e866\u79cd\u4e0d\u540c\u7c7b\u578b\u9aa8\u67b6(atisine-, denudatine-, arcutane-, arcutine-, napelline-, \u4ee5\u53cahetidine-type)\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210\uff08Fig. 4\uff09\u3002<\/p>\n

\"\"<\/a><\/p>\n

Fig. 4 \u4e8c\u841c\u751f\u7269\u78b1\u7684\u5168\u5408\u6210<\/p>\n

4.\u5176\u4ed6\u5e94\u7528\u4e8e\u590d\u6742\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u7684\u521b\u65b0\u7b56\u7565\uff08\u56fe<\/b><\/strong>5<\/b><\/strong>\uff09<\/b><\/strong>15-20<\/b><\/sup><\/strong><\/p>\n

 <\/p>\n

\"\"<\/a><\/p>\n

Fig. 5\u5176\u4ed6\u5e94\u7528\u4e8e\u590d\u6742\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u7684\u521b\u65b0\u7b56\u7565<\/p>\n

\u00a0<\/b><\/strong><\/p>\n

5.\u5148\u8fdb\u836f\u7269\u5236\u90202<\/sup>1<\/sup><\/strong><\/p>\n

\u79e6\u52c7\u6559\u6388\u9488\u5bf9\u590d\u6742\u5929\u7136\u4ea7\u7269\u5408\u6210\u9886\u57df\u4e2d\u9ad8\u6548\u6784\u5efa\u5929\u7136\u4ea7\u7269\u9aa8\u67b6\u7684\u6838\u5fc3\u95ee\u9898\u8fdb\u884c\u6df1\u5165\u7814\u7a76\uff0c\u8fdb\u800c\u4fc3\u8fdb\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5728\u751f\u7269\u5b66\u4e0e\u836f\u7269\u7814\u7a76\u65b9\u9762\u7684\u5e94\u7528\uff0c\u4e3a\u521b\u65b0\u836f\u7269\u7684\u7814\u7a76\u63d0\u4f9b\u6709\u6709\u4ef7\u503c\u7684\u5148\u5bfc\u5316\u5408\u7269\u3002\u9488\u5bf9\u5de5\u4e1a\u4e0a\u5177\u6709\u9ad8\u6280\u672f\u58c1\u5792\u7684\u5929\u7136\u836f\u7269\u54c1\u79cd\uff0c\u53d1\u5c55\u7eff\u8272\u7684\u5408\u6210\u53cd\u5e94\uff0c\u5e76\u5bf9\u5de5\u4e1a\u5316\u751f\u4ea7\u4e2d\u7684\u5173\u952e\u6b65\u9aa4\u8fdb\u884c\u7eff\u8272\u5de5\u827a\u7814\u7a76\uff0c\u9ad8\u6548\u7684\u5408\u6210\u4e0a\u8ff0\u7684\u5929\u7136\u836f\u7269\u54c1\u79cd\uff0c\u8fdb\u800c\u89e3\u51b3\u76f8\u5173\u7684\u6280\u672f\u58c1\u5792\u3002\u5176\u4e2d\u672c\u8bfe\u9898\u7ec4\u53d1\u5c55\u7684\u7684\u73af\u5883\u53cb\u597d\u7684\u3001\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u5965\u5229\u53f8\u4ed6(Orlistat) 9\u6b65\u5168\u5408\u6210\u751f\u4ea7\u8def\u7ebf\u4e0e\u5de5\u827a\uff0c\u6210\u529f\u514b\u670d\u5728\u5de5\u4e1a\u6761\u4ef6\u4e0b\u50ac\u5316\u5242\u7684\u7a33\u5b9a\u6027\u3001\u9ad8\u50ac\u5316\u6548\u7387\u4ee5\u53ca\u975e\u5bf9\u6620\u9009\u62e9\u6027\u7684\u96be\u9898\uff0c\u6700\u7ec8\u5b9e\u73b0\u8fd9\u4e00\u836f\u7269\u7684\u4ea7\u4e1a\u5316\uff0c\u4f7f\u751f\u4ea7\u539f\u6599\u836f\u7684\u6210\u672c\u4e0e\u539f\u53d1\u9175\u5de5\u827a\u76f8\u6bd4\u5927\u5e45\u964d\u4f4e\uff08Fig. 6\uff09\u3002<\/p>\n

\"\"<\/a><\/p>\n

Fig. 6\u5148\u8fdb\u836f\u7269\u5236\u9020<\/p>\n

\u53c2\u8003\u6587\u732e<\/b><\/strong><\/h4>\n
    \n
  1. Yang, J.; Wu, H.; Shen, L.; Qin, Y., J. Am. Chem. Soc. <\/em>2007,<\/strong>129<\/em>(45), 13794-13795, doi:10.1021\/ja075705g.<\/u><\/a><\/li>\n
  2. Shen, L.; Zhang, M.; Wu, Y.; Qin, Y., Angew. Chem. Int. Ed. <\/em>2008,<\/strong>47<\/em>(19), 3618-3621, doi:10.1002\/anie.200800566.<\/u><\/a><\/li>\n
  3. Zhang, M.; Huang, X.; Shen, L.; Qin, Y., J. Am. Chem. Soc. <\/em>2009,<\/strong>131<\/em>(16), 6013-6020, doi:10.1021\/ja901219v.<\/u><\/a><\/li>\n
  4. Zhang, D.; Song, H.; Qin, Y., Acc. Chem. Res. <\/em>2011,<\/strong>44<\/em>(6), 447-457, doi:10.1021\/ar200004w.<\/u><\/a><\/li>\n
  5. Jin, S.; Gong, J.; Qin, Y., Angew. Chem. Int. Ed. <\/em>2015,<\/strong>54<\/em>(7), 2228-2231, doi:10.1002\/anie.201409963.<\/u><\/a><\/li>\n
  6. Leng, L.; Zhou, X.; Liao, Q.; Wang, F.; Song, H.; Zhang, D.; Liu, X.-Y.; Qin, Y., Angew. Chem. Int. Ed. <\/em>2017,<\/strong>56<\/em>(13), 3703-3707, doi:10.1002\/anie.201700831.<\/u><\/a><\/li>\n
  7. Liu, W.; Qin, W.; Wang, X.; Xue, F.; Liu, X.-Y.; Qin, Y., Angew. Chem. Int. Ed. <\/em>2018,<\/strong>57<\/em>(38), 12299-12302, doi:10.1002\/anie.201804848.<\/u><\/a><\/li>\n
  8. Li, W.; Chen, Z.; Yu, D.; Peng, X.; Wen, G.; Wang, S.; Xue, F.; Liu, X.-Y.; Qin, Y., Angew. Chem. Int. Ed. <\/em>2019,<\/strong>58<\/em>(18), 6059-6063, doi:10.1002\/anie.201901074.<\/u><\/a><\/li>\n
  9. Liu, X.-Y.; Qin, Y., Acc. Chem. Res. <\/em>2019,<\/strong>52<\/em>(7), 1877-1891, doi:10.1021\/acs.accounts.9b00246.<\/u><\/a><\/li>\n
  10. Gong, J.; Chen, H.; Liu, X.-Y.; Wang, Z.-X.; Nie, W.; Qin, Y., Nat. Commun. <\/em>2016,<\/strong>7<\/em>(1), 12183, doi:10.1038\/ncomms12183.<\/u><\/a><\/li>\n
  11. Li, X.-H.; Zhu, M.; Wang, Z.-X.; Liu, X.-Y.; Song, H.; Zhang, D.; Wang, F.-P.; Qin, Y., Angew. Chem. Int. Ed. <\/em>2016,<\/strong>55<\/em>(50), 15667-15671, doi:10.1002\/anie.201609882.<\/u><\/a><\/li>\n
  12. Nie, W.; Gong, J.; Chen, Z.; Liu, J.; Tian, D.; Song, H.; Liu, X.-Y.; Qin, Y., J. Am. Chem. Soc. <\/em>2019,<\/strong>141<\/em>(24), 9712-9718, doi:10.1021\/jacs.9b04847.<\/u><\/a><\/li>\n
  13. Huang, H.-X.; Mi, F.; Li, C.; He, H.; Wang, F.-P.; Liu, X.-Y.; Qin, Y., Angew. Chem. Int. Ed. <\/em>2020,<\/strong>59<\/em>(52), 23609-23614, doi:10.1002\/anie.202011923.<\/u><\/a><\/li>\n
  14. Liu, X.-Y.; Wang, F.-P.; Qin, Y., Acc. Chem. Res. <\/em>2021,<\/strong>54<\/em>(1), 22-34, doi:10.1021\/acs.accounts.0c00720.<\/u><\/a><\/li>\n
  15. Zhou, X.; Xiao, T.; Iwama, Y.; Qin, Y., Angew. Chem. Int. Ed. <\/em>2012,<\/strong>51<\/em>(20), 4909-4912, doi:10.1002\/anie.201201736.<\/u><\/a><\/li>\n
  16. Yajima, A.; Qin, Y.; Zhou, X.; Kawanishi, N.; Xiao, X.; Wang, J.; Zhang, D.; Wu, Y.; Nukada, T.; Yabuta, G.; Qi, J.; Asano, T.; Sakagami, Y., Nature Chemical Biology <\/em>2008,<\/strong>4<\/em>(4), 235-237, doi:10.1038\/nchembio.74.<\/u><\/a><\/li>\n
  17. Wu, H.; Xue, F.; Xiao, X.; Qin, Y., J. Am. Chem. Soc. <\/em>2010,<\/strong>132<\/em>(40), 14052-14054, doi:10.1021\/ja1070043.<\/u><\/a><\/li>\n
  18. Wang, Y.; Leng, L.; Liu, Y.; Dai, G.; Xue, F.; Chen, Z.; Meng, J.; Wen, G.; Xiao, Y.; Liu, X.-Y.; Qin, Y., Org. Lett. <\/em>2018,<\/strong>20<\/em>(21), 6701-6704, doi:10.1021\/acs.orglett.8b02779.<\/u><\/a><\/li>\n
  19. Li, Y.; Dong, Q.; Xie, Q.; Tang, P.; Zhang, M.; Qin, Y., Org. Lett. <\/em>2018,<\/strong>20<\/em>(16), 5053-5057, doi:10.1021\/acs.orglett.8b02202.<\/u><\/a><\/li>\n
  20. Dai, X.; Liu, W.; Zhou, Q.; Cheng, C.; Yang, C.; Wang, S.; Zhang, M.; Tang, P.; Song, H.; Zhang, D.; Qin, Y., J. Org. Chem. <\/em>2016,<\/strong>81<\/em>(1), 162-184, doi:10.1021\/acs.joc.5b02468.<\/a><\/u><\/li>\n
  21. \u79e6\u52c7\u6559\u6388\u8bfe\u9898\u7ec4\u4e3b\u9875<\/u><\/a><\/li>\n
  22. \u6587\u4e2d\u56fe\u7247\u5747\u6765\u81ea\u79e6\u52c7\u6559\u6388\u8bfe\u9898\u7ec4<\/u><\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a \u6982\u8981 \u79e6\u52c7\uff1a\u56db\u5ddd\u5927\u5b66\u534e\u897f\u836f\u5b66\u9662\u9662\u957f\uff0c\u5929\u7136\u836f\u7269\u7cfb\u6559\u6388\uff0c\u836f\u7269\u5316\u5b66\u5bb6 \u8bfe\u9898\u7ec4\u4e3b\u9875\uff1ahttp:\/\/www.scu-yongqingroup.com\/ \u7ecf\u5386 1989\u5e74 \u4e91\u5357\u5927\u5b66\uff0c\u5b66\u58eb\u5b66\u4f4d 1992\u5e74 \u6210\u90fd\u6709\u673a\u5316\u5b66\u7814\u7a76\u6240\uff0c\u7855\u58eb\u5b66\u4f4d 1995\u5e74 \u4e2d\u79d1\u9662\u5316\u5b66\u7814\u7a76\u6240\uff0c\u535a\u58eb\u5b66\u4f4d\uff08\u5e08\u4ece\u9ec4\u5fd7\u9557\u9662\u58eb\u4e0e\u848b\u8000\u5fe0\u7814\u7a76\u5458\uff09 1995-1996\u5e74 \u6210\u90fd\u6709\u673a\u5316\u5b66\u7814\u7a76\u6240\u4efb\u52a9\u7406\u7814\u7a76\u5458\uff0c\u526f\u7814\u7a76\u5458 1996-2000\u5e74 \u00a0The University of Vermont, \u5316\u5b66\u7cfb\u535a\u58eb\u540e 2000-2003\u5e74 \u7f8e\u56fdSan Diego\u9ad8\u6280\u672f\u751f\u7269\u5236\u836f\u516c\u53f8(Triad Therapeutics Inc.)\uff0c\u4efb\u7814\u7a76\u79d1\u5b66\u5bb6 2003-\u56db\u5ddd\u5927\u5b66\u534e\u897f\u836f\u5b66\u9662\u6559\u6388 \u83b7\u5956\u7ecf\u5386 2004\u5e74\u56db\u5ddd\u7701\u6770\u51fa\u9752\u5e74\uff1b 2005\u5e74\u56db\u5ddd\u7701\u9752\u5e74\u79d1\u6280\u5956\uff1b 2009\u5e74\u65b0\u4e16\u7eaa\u767e\u5343\u4e07\u4eba\u624d\u5de5\u7a0b\u56fd\u5bb6\u7ea7\u4eba\u9009\uff1b 2009\u5e74\u4eab\u53d7\u56fd\u52a1\u9662\u7279\u6b8a\u6d25\u8d34\u4e13\u5bb6\uff1b 2009\u5e74\u8bc4\u4e3a\u6210\u90fd\u5e02\u6709\u7a81\u51fa\u8d21\u732e\u7684\u4f18\u79c0\u4e13\u5bb6\uff1b 2010\u5e74\u7b2c\u516b\u6279\u56db\u5ddd\u7701\u5b66\u672f\u548c\u6280\u672f\u5e26\u5934\u4eba\uff1b 2010\u5e74\u83b7\u6559\u80b2\u90e8\u767e\u7bc7\u5168\u56fd\u4f18\u79c0\u535a\u58eb\u5b66\u4f4d\u8bba\u6587\u6307\u5bfc\u6559\u5e08\uff1b 2013\u5e74\u83b7\u9996\u5c4a\u4e2d\u56fd\u5316\u5b66\u4f1a”\u7ef4\u5584\u5929\u7136\u4ea7\u7269\u5408\u6210\u5956”\uff1b 2016\u5e74\u83b7\u4e2d\u56fd\u56fd\u5bb6\u77e5\u8bc6\u4ea7\u6743\u5c40\u7b2c\u5341\u516b\u5c4a\u4e2d\u56fd\u4e13\u5229\u5956\u4f18\u79c0\u5956\uff1b 2017\u5e74\u83b7\u6559\u80b2\u90e8\u81ea\u7136\u79d1\u5b66\u5956\u4e00\u7b49\u5956\uff1b 2017\u5e74\u56db\u5ddd\u7701\u536b\u751f\u8ba1\u751f\u9996\u5e2d\u4e13\u5bb6\uff1b 2018\u5e74\u83b7\u7b2c\u4e09\u5c4a\u4e2d\u56fd\u836f\u5b66\u4f1a\u2012\u4ee5\u5cad\u751f\u7269\u533b\u836f\u521b\u65b0\u5956\uff1b 2019\u5e74\u83b7\u7b2c\u4e8c\u5341\u5c4a\u5434\u9636\u5e73-\u4fdd\u7f57\u6768\u68ee\u533b\u5b66\u836f\u5b66\u5956(\u5434\u6768\u5956)\u3002 \u7814\u7a76\u65b9\u5411 \u79e6\u52c7\u6559\u6388\u76ee\u524d\u4e3b\u8981\u4ece\u4e8b\u5177\u6709\u91cd\u8981\u751f\u7406\u6d3b\u6027\u7684\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210\u53ca\u836f\u7269\u5316\u5b66\u7814\u7a76\u3002 \u590d\u6742\u751f\u7406\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210 \u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u662f\u6765\u81ea\u5927\u81ea\u7136\u5bf9\u4eba\u7c7b\u7684\u6311\u6218\u4e0e\u673a\u9047\u3002\u4ece\u7b80\u5355\u5230\u590d\u6742\uff0c\u81ea\u4eba\u7c7b\u9996\u6b21\u4ece\u81ea\u7136\u754c\u4e2d\u5206\u79bb\u51fa\u5929\u7136\u4ea7\u7269\u4e4b\u540e\uff0c\u79d1\u5b66\u5bb6\u4fbf\u4e00\u76f4\u4e0d\u65ad\u5730\u5c1d\u8bd5\u5f00\u53d1\u4e00\u7cfb\u5217\u4eba\u5de5\u5408\u6210\u5929\u7136\u4ea7\u7269\u7684\u65b0\u65b9\u6cd5\uff0c\u4ece\u5c0f\u5206\u5b50\u5230\u5927\u5206\u5b50\uff0c\u79d1\u5b66\u5bb6\u4eec\u5728\u5929\u7136\u4ea7\u7269\u5408\u6210\u7684\u7814\u7a76\u4e2d\u9010\u6e10\u524d\u884c\u3002\u79e6\u52c7\u6559\u6388\u8bfe\u9898\u7ec4\u9488\u5bf9\u590d\u6742\u5929\u7136\u4ea7\u7269\u5408\u6210\u9886\u57df\u4e2d\u9ad8\u6548\u6784\u5efa\u5929\u7136\u4ea7\u7269\u9aa8\u67b6\u7684\u6838\u5fc3\u95ee\u9898\u8fdb\u884c\u6df1\u5165\u7814\u7a76\uff0c\u81f4\u529b\u4e8e\u53d1\u5c55\u76f8\u5173\u7684\u521b\u65b0\u5408\u6210\u7b56\u7565\uff0c\u8fdb\u800c\u4fc3\u8fdb\u5404\u7c7b\u751f\u7406\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5728\u751f\u7269\u5b66\u4e0e\u836f\u7269\u7814\u7a76\u65b9\u9762\u7684\u5e94\u7528\uff0c\u4e3a\u521b\u65b0\u836f\u7269\u7684\u7814\u7a76\u63d0\u4f9b\u5148\u5bfc\u5316\u5408\u7269\u3002\u76ee\u524d\uff0c\u79e6\u52c7\u6559\u6388\u5f00\u53d1\u7684 (Cyclopropanation\/Ring-opening\/Iminium cyclization)\u00a0\u73af\u4e19\u70f7\u5316-\u5f00\u73af-\u4e9a\u80fa\u73af\u5408\u7684\u4e32\u8054\u53cd\u5e94\u4e0e\uff08Nitrogen Radical Cascade Reactions\uff09\u6c2e\u81ea\u7531\u57fa\u4e32\u8054\u53cd\u5e94\u4e3a\u4ee3\u8868\u7684\u521b\u65b0\u5408\u6210\u7b56\u7565\u4e0e\u65b9\u6cd5\uff0c\u6210\u529f\u5b9e\u73b0\u90e8\u5206\u5929\u7136\u4ea7\u7269\u7684\u89c4\u6a21\u5316\u5236\u5907\uff0c\u5e76\u5b8c\u6210\u4e86\u7ed3\u6784\u6700\u4e3a\u590d\u6742\u7684\u4ee5\u5432\u54da\u751f\u7269\u78b1\u4e0e\u4e8c\u841c\u751f\u7269\u78b1\u4e3a\u4ee3\u8868\u768470\u591a\u79cd\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210\uff0c\u5176\u4e2d21\u4e2d\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210\u4e3a\u56fd\u9645\u4e0a\u7684\u9996\u6b21\u5408\u6210\uff0c\u90e8\u5206\u7814\u7a76\u5de5\u4f5c\u88ab\u8bc4\u4e3a\u5168\u5408\u6210\u9886\u57df\u4e2d\u7684\u7a81\u7834\u6027\u8fdb\u5c55\u3002 1.\u57fa\u4e8e\u73af\u4e19\u70f7\u5316-\u5f00\u73af-\u4e9a\u80fa\u73af\u5408\u7684\u4e32\u8054\u53cd\u5e94\u7b56\u7565\u7684\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210 \u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\uff0c\u7279\u522b\u662f\u590d\u6742\u5929\u7136\u4ea7\u7269\u5206\u5b50\u7684\u5168\u5408\u6210\uff0c\u4e00\u76f4\u662f\u5206\u5b50\u7ea7\u522b\u201c\u5efa\u7b51\u8bbe\u8ba1\u5e08\u201d\u7684\u5168\u5408\u6210\u5316\u5b66\u5bb6\u6240\u8ffd\u6c42\u7684\u76ee\u6807\u3002Indoline alkaloids\u662f\u5927\u81ea\u7136\u7ed9\u4e88\u4eba\u7c7b\u7684\u6700\u597d\u9988\u8d60\u3002\u5432\u54da\u5549\u751f\u7269\u78b1\u662f\u5929\u7136\u4ea7\u7269\u4e2d\u7684\u4e00\u4e2a\u5927\u7c7b\uff0c\u7531\u4e8e\u8be5\u7c7b\u5316\u5408\u7269\u591a\u6837\u800c\u590d\u6742\u7684\u7ed3\u6784\uff0c\u4f7f\u5176\u5177\u6709\u8f83\u9ad8\u7684\u751f\u7269\u6d3b\u6027\uff0c\u5e76\u5728\u6297\u80bf\u7624\u3001\u764c\u75c7\u4ee5\u53ca\u5176\u4ed6\u75be\u75c5\u4e2d\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u6548\u679c\u3002Qin\u8bfe\u9898\u7ec4\u81f4\u529b\u4e8e\u53d1\u5c55\u521b\u65b0\u5408\u6210\u7b56\u7565\uff0c\u6784\u5efa\u4e0d\u540c\u7ed3\u6784\u7684\u5432\u54da\u5549\u751f\u7269\u78b1\uff0c\u8fdb\u800c\u4fc3\u8fdb\u5728\u751f\u7269\u5b66\u4e0e\u836f\u7269\u7814\u7a76\u65b9\u9762\u7684\u5e94\u7528\uff0c\u4e3a\u521b\u65b0\u836f\u7269\u7684\u7814\u7a76\u63d0\u4f9b\u5148\u5bfc\u5316\u5408\u7269\u3002\u79e6\u52c7\u6559\u6388\u5c0f\u7ec4\u9009\u62e9\u5177\u6709\u91cd\u8981\u836f\u7528\u4ef7\u503c\u7684\u5432\u54da\u751f\u7269\u78b1\u4f5c\u4e3a\u7814\u7a76\u5bf9\u8c61\uff0c\u539f\u521b\u6027\u5730\u53d1\u5c55\u4e86\u4e00\u79cd\u57fa\u4e8eIndoline alkaloids\u9aa8\u67b6\u4e2d\u8272\u80fa\u57fa\u56e2\u7684\u73af\u4e19\u70f7\u5316-\u5f00\u73af-\u4e9a\u80fa\u73af\u5408\u7684\u4e32\u8054\u53cd\u5e94(cyclopropanation\/ring-opening\/iminium cyclization)\uff08CRI\u53cd\u5e94\uff09\uff0c\u6210\u529f\u5730\u5efa\u7acb\u4e94\u79cd\u590d\u6742\u5432\u54da\u751f\u7269\u78b1\u9aa8\u67b6\uff08Type I-Type V\uff09\u7684\u901a\u7528\u6784\u5efa\u65b9\u6cd51-6\u3002\u540c\u65f6\uff0cQin\u5c0f\u7ec4\u8fdb\u4e00\u6b65\u5e94\u7528\u8fd9\u4e00\u7b56\u7565\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u4e00\u7cfb\u5217\u590d\u6742\u5432\u54da\u751f\u7269\u78b1\u7684\u5168\u5408\u6210\uff08Fig. 1\uff09\u3002 Fig. 1\u57fa\u4e8e\u73af\u4e19\u70f7\u5316-\u5f00\u73af-\u4e9a\u80fa\u73af\u5408\u7684\u4e32\u8054\u53cd\u5e94\u7b56\u7565\u7684\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210 2.\u57fa\u4e8e\u53ef\u89c1\u5149\u50ac\u5316\u4ea7\u751f\u6c2e\u81ea\u7531\u57fa\u7b56\u7565\u7684\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210 Monoterpene indole alkaloids, \u5305\u542b3000\u591a\u79cd\u5df2\u77e5\u6210\u5458\u4e0e40\u591a\u79cd\u4e0d\u540c\u7684\u7ed3\u6784\u7c7b\u578b\uff0c\u662f\u6700\u5927\u7684\u5929\u7136\u4ea7\u7269\u5bb6\u65cf\u4e4b\u4e00\uff0c\u540c\u65f6\uff0c\u4e5f\u662f\u662f\u91cd\u8981\u7684\u836f\u7269\u6765\u6e90\u3002\u6570\u5341\u5e74\u6765\uff0c\u5176\u590d\u6742\u7684\u5316\u5b66\u7ed3\u6784\u4e0e\u4f18\u826f\u7684\u751f\u7269\u5b66\u6d3b\u6027\uff0c\u4f7f\u8fd9\u7c7b\u751f\u7269\u78b1\u6210\u4e3a\u201c\u5929\u7136\u4ea7\u7269\u5efa\u7b51\u5e08\u201d\u773c\u4e2d\u6700\u6709\u5438\u5f15\u529b\u7684\u7ed3\u6784\u5355\u5143\u3002\u5c3d\u7ba1\u5316\u5b66\u5bb6\u00a0\u4e3aMonoterpene indole alkaloids,\u7684\u5408\u6210\u53d1\u5c55\u8bb8\u591a\u7684\u5408\u6210\u65b9\u6cd5\u4e0e\u7b56\u7565\uff0c\u7136\u800c\uff0c\u53d1\u5c55\u4e00\u79cd\u5bf9\u4e8e\u4e00\u7cfb\u5217\u4e0d\u540c\u7ed3\u6784\u7c7b\u578b\u7684\u5355\u841c\u5432\u54da\u751f\u7269\u78b1\u7684\u5168\u5408\u6210\u66f4\u4e3a\u901a\u7528\u7684\u7b56\u7565\uff0c\u4ecd\u7136\u5b58\u5728\u8f83\u5927\u7684\u6311\u6218\u3002\u8fd1\u5e74\u6765\uff0c\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u5df2\u7ecf\u6210\u4e3a\u4e00\u79cd\u5f3a\u6709\u529b\u7684\u5de5\u5177\uff0c\u53ef\u4ee5\u901a\u8fc7\u5355\u7535\u5b50\u8f6c\u79fb\uff08SET\uff09\u8fc7\u7a0b\u5b9e\u73b0\u4e00\u7cfb\u5217\u76f8\u5e94\u7684\u5408\u6210\u8f6c\u5316\uff0c\u79e6\u52c7\u6559\u6388\u5c0f\u7ec4\u5c06\u5149\u50ac\u5316\u5e94\u7528\u4e0e\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u4e2d\uff0c\u521b\u65b0\u6027\u5730\u53d1\u5c55\u4e86\u4e00\u79cd\u5728\u53ef\u89c1\u5149\u50ac\u5316\u6761\u4ef6\u4e0b\uff0c\u901a\u8fc7\u53bb\u8d28\u5b50\u5316\u4e0e\u6c27\u5316\u8fc7\u7a0b\uff0c\u5c06\u82ef\u80faN-H\u5b98\u80fd\u56e2\u8f6c\u5316\u4e3a\u6c2e\u81ea\u7531\u57fa\uff0c\u8fdb\u800c\u901a\u8fc7\u5206\u5b50\u5185\u52a0\u6210\u7684\u65b9\u5f0f\uff0c\u987a\u5229\u5c06\u8fd9\u79cd\u7f3a\u7535\u5b50\u7684\u6c2e\u81ea\u7531\u57fa\u5f15\u5165\u81f3\u5bcc\u7535\u5b50\u7684\u70ef\u80fa\u5355\u5143\u7684\u03b2-\u78b3\u539f\u5b50\u4e2d\uff0c\u5e76\u8fdb\u4e00\u6b65\u5f15\u53d1\u5206\u5b50\u5185\/\u5206\u5b50\u5185\u3001\u5206\u5b50\u5185\/\u5206\u5b50\u95f4\u4ee5\u53ca\u5206\u5b50\u5185\/\u5206\u5b50\u95f4\/\u5206\u5b50\u5185\u7684\u4e09\u79cd\u7c7b\u578b\u7684\u81ea\u7531\u57fa\u4e32\u8054\u53cd\u5e947-9\uff08Fig. 2 \uff09\uff0c\u4e00\u9505\u591a\u6b65\u5730\u5b9e\u73b0\u5982\u4e0b\u56fe\u6240\u793a\u7684\u767d\u575a\u6728\u578b\uff08Type I\uff09\u00a0(Aspidosperma (type I))\u3001\u56db\u6c22\u5494\u6ce2\u5549\u578b\uff08Type II\uff09(tetrahydrocarbolinone (type II))\u548c\u67ef\u6960\u56e0\u578b\uff08Type III\uff09(Corynanthe (type III))\u4e09\u79cd\u5b98\u80fd\u5316\u7684\u624b\u6027\u5355\u841c\u5432\u54da\u751f\u7269\u78b1\u9aa8\u67b6\u7684\u9ad8\u6548\u5408\u6210\u3002\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u8fd0\u7528\u4e0a\u8ff0\u7b56\u7565\uff0c\u6700\u7ec8\u5b9e\u73b0\u4e8633\u4e2a\u5206\u5c5e\u4e8e\u56db\u4e2a\u4e0d\u540c\u5bb6\u65cf\u7684\u5355\u841c\u5432\u54da\u751f\u7269\u78b1\u7684\u9ad8\u6548\u96c6\u7fa4\u5f0f\u5408\u6210(\u00a0Collective Total Synthesis)\uff08\u56fe3\uff09\u3002 Fig. 2 \u53ef\u89c1\u5149\u50ac\u5316\u4ea7\u751f\u6c2e\u81ea\u7531\u57fa\u7b56\u7565 Fig. 3 \u5355\u841c\u5432\u54da\u751f\u7269\u78b1\u7684\u9ad8\u6548\u96c6\u7fa4\u5f0f\u5408\u6210 3.\u4e8c\u841c\u751f\u7269\u78b1\u7684\u5168\u5408\u6210 \u4e09\u7ef4\u7b3c\u72b6\u5929\u7136\u4ea7\u7269(Three-dimensional cage-like natural products)\u662f\u5168\u5408\u6210\u7814\u7a76\u4e2d\u7684\u957f\u671f\u6311\u6218\u4e4b\u4e00\u3002\u4f5c\u4e3a\u4e4c\u5934\u5c5e(Aconitum)\u548c\u98de\u71d5\u8349(Delphinium)\u5c5e\u690d\u7269\u7684\u7279\u5f81\u6210\u5206\uff0c\u8fd9\u4e9b\u5206\u5b50\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u751f\u7269\u6d3b\u6027\uff0c\u5176\u4e2d\u4e00\u4e9b\u5df2\u7ecf\u7528\u4f5c\u4e34\u5e8a\u836f\u7269\u3002\u66f4\u5f15\u4eba\u6ce8\u76ee\u7684\u662f\uff0c\u5b83\u4eec\u590d\u6742\u800c\u7f8e\u4e3d\u7684\u7ed3\u6784\u4f7f\u5f97\u4e8c\u841c\u751f\u7269\u78b1\u6210\u4e3a\u201c\u5929\u7136\u4ea7\u7269\u5efa\u7b51\u5e08\u201d\u773c\u4e2d\u7684\u8c61\u7259\u5854\u3002\u79e6\u52c7\u6559\u6388\u5c0f\u7ec4\u9488\u5bf9\u5177\u6709\u590d\u6742\u7ed3\u6784\u4e0e\u5e7f\u6cdb\u751f\u7406\u6d3b\u6027\u7684\u4e8c\u841c\u751f\u7269\u78b1\u7c7b\u5929\u7136\u4ea7\u7269\uff0c\u7cfb\u7edf\u6027\u5730\u91c7\u7528\u6c27\u5316\u53bb\u82b3\u9999\u5316\/Diels-Alder\u73af\u52a0\u6210\u4f5c\u4e3a\u5173\u952e\u7684\u53cd\u5e94\u7b56\u7565\uff0c\u6210\u529f\u7684\u6784\u5efa\u8d77\u76ee\u6807\u5206\u5b50\u4e2d\u666e\u904d\u5b58\u5728\u7684[2.2.2]\u53cc\u73af\u5355\u5143\u53ca\u5176\u76f8\u5173\u7684\u73af\u626d\u66f2\u884d\u751f\u7269\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u591a\u79cd\u6e90\u4e8e\u4e4c\u5934\u5c5e(Aconitum)\u7684\u4e8c\u841c\u751f\u7269\u78b1 (Diterpenoid alkaloids)\u53ca\u76f8\u5e94\u7684\u4e8c\u841c\u5206\u5b50\u7684\u5168\u5408\u621010-14\u3002\u76ee\u524d\uff0c\u79e6\u52c7\u6559\u6388\u5c0f\u7ec4\u5df2\u7ecf\u5b9e\u73b0\u4e866\u79cd\u4e0d\u540c\u7c7b\u578b\u9aa8\u67b6(atisine-, denudatine-, arcutane-, arcutine-, napelline-, \u4ee5\u53cahetidine-type)\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210\uff08Fig. 4\uff09\u3002 Fig. 4 \u4e8c\u841c\u751f\u7269\u78b1\u7684\u5168\u5408\u6210 4.\u5176\u4ed6\u5e94\u7528\u4e8e\u590d\u6742\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u7684\u521b\u65b0\u7b56\u7565\uff08\u56fe5\uff0915-20   Fig. 5\u5176\u4ed6\u5e94\u7528\u4e8e\u590d\u6742\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u7684\u521b\u65b0\u7b56\u7565 \u00a0 5.\u5148\u8fdb\u836f\u7269\u5236\u902021 \u79e6\u52c7\u6559\u6388\u9488\u5bf9\u590d\u6742\u5929\u7136\u4ea7\u7269\u5408\u6210\u9886\u57df\u4e2d\u9ad8\u6548\u6784\u5efa\u5929\u7136\u4ea7\u7269\u9aa8\u67b6\u7684\u6838\u5fc3\u95ee\u9898\u8fdb\u884c\u6df1\u5165\u7814\u7a76\uff0c\u8fdb\u800c\u4fc3\u8fdb\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5728\u751f\u7269\u5b66\u4e0e\u836f\u7269\u7814\u7a76\u65b9\u9762\u7684\u5e94\u7528\uff0c\u4e3a\u521b\u65b0\u836f\u7269\u7684\u7814\u7a76\u63d0\u4f9b\u6709\u6709\u4ef7\u503c\u7684\u5148\u5bfc\u5316\u5408\u7269\u3002\u9488\u5bf9\u5de5\u4e1a\u4e0a\u5177\u6709\u9ad8\u6280\u672f\u58c1\u5792\u7684\u5929\u7136\u836f\u7269\u54c1\u79cd\uff0c\u53d1\u5c55\u7eff\u8272\u7684\u5408\u6210\u53cd\u5e94\uff0c\u5e76\u5bf9\u5de5\u4e1a\u5316\u751f\u4ea7\u4e2d\u7684\u5173\u952e\u6b65\u9aa4\u8fdb\u884c\u7eff\u8272\u5de5\u827a\u7814\u7a76\uff0c\u9ad8\u6548\u7684\u5408\u6210\u4e0a\u8ff0\u7684\u5929\u7136\u836f\u7269\u54c1\u79cd\uff0c\u8fdb\u800c\u89e3\u51b3\u76f8\u5173\u7684\u6280\u672f\u58c1\u5792\u3002\u5176\u4e2d\u672c\u8bfe\u9898\u7ec4\u53d1\u5c55\u7684\u7684\u73af\u5883\u53cb\u597d\u7684\u3001\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u5965\u5229\u53f8\u4ed6(Orlistat) 9\u6b65\u5168\u5408\u6210\u751f\u4ea7\u8def\u7ebf\u4e0e\u5de5\u827a\uff0c\u6210\u529f\u514b\u670d\u5728\u5de5\u4e1a\u6761\u4ef6\u4e0b\u50ac\u5316\u5242\u7684\u7a33\u5b9a\u6027\u3001\u9ad8\u50ac\u5316\u6548\u7387\u4ee5\u53ca\u975e\u5bf9\u6620\u9009\u62e9\u6027\u7684\u96be\u9898\uff0c\u6700\u7ec8\u5b9e\u73b0\u8fd9\u4e00\u836f\u7269\u7684\u4ea7\u4e1a\u5316\uff0c\u4f7f\u751f\u4ea7\u539f\u6599\u836f\u7684\u6210\u672c\u4e0e\u539f\u53d1\u9175\u5de5\u827a\u76f8\u6bd4\u5927\u5e45\u964d\u4f4e\uff08Fig. 6\uff09\u3002 Fig. 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