{"id":38862,"date":"2021-06-04T08:00:41","date_gmt":"2021-06-04T00:00:41","guid":{"rendered":"\/\/www.gsbet888.com\/?p=38862"},"modified":"2021-05-31T10:37:07","modified_gmt":"2021-05-31T02:37:07","slug":"%e5%b8%b8%e5%b7%9e%e5%a4%a7%e5%ad%a6%e5%8f%b2%e4%b8%80%e5%ae%89%e6%95%99%e6%8e%88%e8%af%be%e9%a2%98%e7%bb%84org-lett-%ef%bc%9a-%e9%92%af%e5%82%ac%e5%8c%96%e4%ba%8c%e6%b0%ae%e4%b8%99%e5%95%b6%e9%85%ae","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2021\/06\/%e5%b8%b8%e5%b7%9e%e5%a4%a7%e5%ad%a6%e5%8f%b2%e4%b8%80%e5%ae%89%e6%95%99%e6%8e%88%e8%af%be%e9%a2%98%e7%bb%84org-lett-%ef%bc%9a-%e9%92%af%e5%82%ac%e5%8c%96%e4%ba%8c%e6%b0%ae%e4%b8%99%e5%95%b6%e9%85%ae.html","title":{"rendered":"\u5e38\u5dde\u5927\u5b66\u53f2\u4e00\u5b89\u6559\u6388\u8bfe\u9898\u7ec4Org. Lett.\uff1a \u94af\u50ac\u5316\u4e8c\u6c2e\u4e19\u5576\u916e\u5408\u6210\u5432\u54da\uff08\u6d89\u53caC-H\u6d3b\u5316\/\u80fa\u5316\uff09"},"content":{"rendered":"

\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749<\/strong><\/p>\n

\u5bfc\u8bfb<\/h4>\n

\u8fd1\u65e5\uff0c\u5e38\u5dde\u5927\u5b66\u53f2\u4e00\u5b89\u6559\u6388\u8bfe\u9898\u7ec4\u5728Org<\/em>anic<\/em>\u00a0Let<\/em>ters<\/em>\u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e86\u5728\u94af\u50ac\u5316\u4e0b\uff0c\u75312-\u7898\u82ef\u4e59\u70ef\u548c\u4e8c\u53d4\u4e01\u57fa\u4e8c\u6c2e\u4e19\u5576\u916e\uff08diaziridinone\uff09\u5408\u6210\u5432\u54da\u7684\u7b56\u7565\uff0c\u6210\u529f\u6784\u5efa\u4e86\u4e24\u4e2a\u65b0\u7684C-N\u952e\u3002\u540c\u65f6\uff0c\u8be5\u53cd\u5e94\u6d89\u53ca\u5c06Pd\u6c27\u5316\u63d2\u5165\u81f3\u82b3\u57fa\u7898\u4e2d\uff0c\u518d\u5c06\u4e59\u70ef\u57faC-H\u952e\u6d3b\u5316\u4e3a\u94af\uff08II\uff09\u73af\u4e2d\u95f4\u4f53\uff0c\u968f\u540e\u901a\u8fc7\u4e8c\u53d4\u4e01\u57fa\u4e8c\u6c2e\u4e19\u5576\u916e\u5c06\u5176\u8fdb\u884c\u53cc\u80fa\u57fa\u5316\uff08bisaminated\uff09\u7684\u8fc7\u7a0b\uff0c\u4ece\u800c\u5f97\u5230\u5432\u54da\u4ea7\u7269\u3002<\/p>\n

Palladium-Catalyzed Sequential C\u2212H Activation\/Amination with\u00a0Diaziridinone: An Approach to Indoles<\/p>\n

Jing Li, Jinhua Chen, Luying Wang, and Yian Shi*<\/p>\n

Org. Lett.<\/em>ASAPDOI:10.1021\/acs.orglett.1c01043<\/u><\/a><\/p><\/blockquote>\n

\"\"<\/a><\/p>\n

\u6b63\u6587<\/h4>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"\"\"\"\"<\/a><\/p>\n

\u7d27\u63a5\u7740\uff0c\u4f5c\u8005\u5bf9\u53cd\u5e94\u7684\u5b9e\u7528\u6027\u8fdb\u884c\u4e86\u7814\u7a76\u30029a<\/strong>\u7684\u514b\u7ea7\u5b9e\u9a8c\uff0c\u53ef\u83b7\u5f9786\uff05\u6536\u7387\u7684\u5432\u54da\u5316\u5408\u726914a<\/strong>\uff08Scheme 4\uff09\u3002\u540c\u65f6\uff0c\u5316\u5408\u726914a<\/strong>\u53ef\u5728CF3<\/sub>SO3<\/sub>H\u7684\u73af\u5df1\u70f7\u6eb6\u5242\u4e2d\u53cd\u5e94\uff0c\u53ef\u8f7b\u677e\u9664\u53bb\u53d4\u4e01\u57fa\uff0c\u4ee570\uff05\u7684\u6536\u7387\u5f97\u5230\u8131\u4fdd\u62a4\u7684\u5432\u54da15<\/strong>\uff08Scheme 5\uff09\u3002<\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

\"\"<\/a><\/p>\n

\u968f\u540e\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u4e00\u79cd\u53ef\u80fd\u7684\u53cd\u5e94\u673a\u7406\uff08Scheme 6\uff09\u3002\u9996\u5148\uff0cPd(0)\u50ac\u5316\u5242\u6c27\u5316\u52a0\u6210\u81f3\u82b3\u57fa\u7898\u5316\u7269\u4e0a\uff0c\u5f62\u6210\u82b3\u57faPd(II)\u914d\u5408\u726916<\/strong>\uff0c\u7ecf\u5206\u5b50\u5185\u4e59\u70ef\u57faC-H\u6d3b\u5316\u751f\u6210\u94af(II)\u73af\u914d\u5408\u726917<\/strong>\u3002\u968f\u540e\uff0c\u914d\u5408\u726917<\/strong>\u4e0e\u4e8c\u53d4\u4e01\u57fa\u4e8c\u6c2e\u4e19\u5576\u916e\uff081<\/strong>\uff09\u53cd\u5e94\uff0c\u751f\u6210\u94af(IV)\u73af\u914d\u5408\u726918<\/strong>\u3002\u5728Path a\u4e2d\uff0c\u914d\u5408\u726918<\/strong>\u91ca\u653e\u5f02\u6c30\u9178\u53d4\u4e01\u57fa\u916f\uff0c\u751f\u6210Pd(IV)-\u6c2e\u6742\u73af\u4e01\u70f719<\/strong>\uff0c\u518d\u7ecf\u8fde\u7eed\u4e24\u6b21\u8fd8\u539f\u6d88\u9664\u5f62\u6210\u5432\u54da14a<\/strong>\uff0c\u5e76\u518d\u751fPd\u50ac\u5316\u3002\u5728Path b\u4e2d\uff0c\u914d\u5408\u726918<\/strong>\u901a\u8fc7\u8fd8\u539f\u6d88\u9664\u5f62\u6210\u516b\u5143\u94af(II)\u73af\u914d\u5408\u726920<\/b><\/strong>\uff0c\u518d\u91ca\u653e\u5f02\u6c30\u9178\u53d4\u4e01\u916f\u4ee5\u53ca\u7ecf\u8fd8\u539f\u6d88\u9664\u540e\uff0c\u5373\u53ef\u83b7\u5f97\u5432\u54da14a<\/strong>\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u5bf9\u7a7a\u95f4\u4f4d\u963b\u548c\u53d6\u4ee3\u6548\u5e94\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u5f53\u4f7f\u7528(E<\/em>)-\u4e09\u53d6\u4ee3\u70ef\u70c39m<\/strong>\u548c(Z<\/em>)-\u4e09\u53d6\u4ee39r<\/strong>\u5728\u6807\u51c6\u6761\u4ef6\u4e0b\u53cd\u5e94\u65f6\uff0c\u4ec5\u6709(E<\/em>)-9m<\/strong>\u987a\u5229\u53cd\u5e94\uff0c\u83b7\u5f9776\uff05\u6536\u7387\u768414m<\/strong>\uff0c\u4ece\u800c\u8868\u660e\u5432\u54da\u5f62\u6210\u6d89\u53ca\u5206\u5b50\u5185\u4e59\u70ef\u57faC-H\u952e\u7684\u6d3b\u5316\uff08Scheme 7\uff09\u3002\u540c\u65f6\uff0c\u70ef\u70c3\u53d6\u4ee3\u57fa\u5bf9\u53cd\u5e94\u4e5f\u81f3\u5173\u91cd\u8981\uff08Scheme 8\uff09\u3002\u5f53\u03b1<\/em>-\u7532\u57fa\u82ef\u4e59\u70ef\u4e2d\u7684\u7532\u57fa\u88ab\u53bb\u9664\u65f6\uff0c\u6536\u7387\u4ece90\uff05\u4e0b\u964d\u5230\u4e0d\u8db35\uff05\uff089a<\/strong>\u00a0vs 9s<\/strong>\uff09\u3002\u4f46\u5f53\u5c06\u7532\u57fa\u90bb\u4f4d\u5f15\u5165\u4e59\u70ef\u57fa\u65f6\uff0c\u4f1a\u5f62\u6210\u5927\u91cf\u7684\u5432\u54da\uff089u<\/strong>\u00a0vs 9s<\/strong>\uff09\u3002\u57289m<\/strong>\u30019t<\/strong>\u548c9v<\/strong>\u4e0b\u4e5f\u89c2\u5bdf\u5230\u4e86\u76f8\u540c\u7684\u8d8b\u52bf\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u4e59\u70ef\u57fa\u548c\u82ef\u57fa\u4e4b\u95f4\u7684\u7a7a\u95f4\u6392\u65a5\u53ef\u4ee5\u4fc3\u8fdbC-H\u952e\u7684\u6d3b\u5316\u3002<\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

\"\"<\/a><\/p>\n

\u603b\u7ed3<\/h4>\n

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\u53c2\u8003\u6587\u732e<\/h4>\n[1] Ramirez, T. A.; Wang, Q.; Zhu, Y.; Zheng, H.; Peng, X.;\u00a0Cornwall, R. G.; Shi, Y. Pd(0)-Catalyzed Sequential C-N Bond\u00a0Formation via Allylic and Aromatic C-H Amination of \u03b1-Methylstyrenes with Diaziridinone.\u00a0Org. Lett.<\/em>\u00a02013<\/strong>, 15<\/em>, 4210\u22124213.<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb \u8fd1\u65e5\uff0c\u5e38\u5dde\u5927\u5b66\u53f2\u4e00\u5b89\u6559\u6388\u8bfe\u9898\u7ec4\u5728Organic\u00a0Letters\u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e86\u5728\u94af\u50ac\u5316\u4e0b\uff0c\u75312-\u7898\u82ef\u4e59\u70ef\u548c\u4e8c\u53d4\u4e01\u57fa\u4e8c\u6c2e\u4e19\u5576\u916e\uff08diaziridinone\uff09\u5408\u6210\u5432\u54da\u7684\u7b56\u7565\uff0c\u6210\u529f\u6784\u5efa\u4e86\u4e24\u4e2a\u65b0\u7684C-N\u952e\u3002\u540c\u65f6\uff0c\u8be5\u53cd\u5e94\u6d89\u53ca\u5c06Pd\u6c27\u5316\u63d2\u5165\u81f3\u82b3\u57fa\u7898\u4e2d\uff0c\u518d\u5c06\u4e59\u70ef\u57faC-H\u952e\u6d3b\u5316\u4e3a\u94af\uff08II\uff09\u73af\u4e2d\u95f4\u4f53\uff0c\u968f\u540e\u901a\u8fc7\u4e8c\u53d4\u4e01\u57fa\u4e8c\u6c2e\u4e19\u5576\u916e\u5c06\u5176\u8fdb\u884c\u53cc\u80fa\u57fa\u5316\uff08bisaminated\uff09\u7684\u8fc7\u7a0b\uff0c\u4ece\u800c\u5f97\u5230\u5432\u54da\u4ea7\u7269\u3002 Palladium-Catalyzed Sequential C\u2212H Activation\/Amination with\u00a0Diaziridinone: An Approach to Indoles Jing Li, Jinhua Chen, Luying Wang, and Yian Shi* Org. Lett.ASAPDOI:10.1021\/acs.orglett.1c01043 \u6b63\u6587 \u5432\u54da\u5316\u5408\u7269\u5e7f\u6cdb\u5b58\u5728\u4e8e\u751f\u7269\u6d3b\u6027\u5206\u5b50\u3001\u836f\u7269\u3001\u6750\u6599\u7b49\u4e2d\u3002\u76ee\u524d\uff0c\u5df2\u6709\u5927\u91cf\u6587\u732e\u62a5\u9053\u4e86\u5432\u54da\u5316\u5408\u7269\u7684\u5408\u6210\uff0c\u5176\u4e2d\u91d1\u5c5e\u50ac\u5316C-H\u80fa\u5316\u53cd\u5e94\u4f5c\u4e3a\u5408\u6210\u5432\u54da\u7684\u9ad8\u6548\u7b56\u7565\u4e4b\u4e00\uff0c\u53ef\u5feb\u901f\u6784\u5efaC-N\u65b0\u952e\u3002\u524d\u671f\uff0c\u8be5\u8bfe\u9898\u7ec4[1]\u62a5\u9053\u4e86\u5728\u94af\u50ac\u5316\u4e0b\uff0c\u4e8c\u53d4\u4e01\u57fa\u4e8c\u6c2e\u4e19\u5576\u916e\uff081\uff09\u548c\u03b1-\u7532\u57fa\u82ef\u4e59\u70ef\u5408\u6210\u87ba\u4e8c\u6c22\u5432\u54da4\u7684\u7b56\u7565\uff0c\u6d89\u53ca\u70ef\u4e19\u57fa\u548c\u82b3\u57fa\u7684C-H\u6d3b\u5316\u4ee5\u5f62\u6210\u94af\uff08II\uff09\u73af\u4e2d\u95f4\u4f532\uff0c\u4e2d\u95f4\u4f532\u88ab\u4e8c\u53d4\u4e01\u57fa\u4e8c\u6c2e\u4e19\u5576\u916e\uff081\uff09\u62e6\u622a\uff0c\u901a\u8fc7\u94af\uff08IV\uff09\u73af\u4e2d\u95f4\u4f533\u4ee5\u751f\u6210\u87ba\u4e8c\u6c22\u5432\u54da4\uff08Scheme 1, eq a\uff09\u3002\u540c\u65f6\uff0c\u7531Heck\/\u82b3\u57faC-H\u6d3b\u5316\u4ea7\u751f\u7684\u94af\u73af\u4e2d\u95f4\u4f53 6\u4e5f\u53ef\u88ab\u4e8c\u53d4\u4e01\u57fa\u4e8c\u6c2e\u4e19\u5576\u916e\uff081\uff09\u6355\u83b7\uff0c\u5f97\u5230\u4e8c\u6c22\u5432\u54da8\uff08Scheme 1, eq b\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u94af\u73af\u7684\u53cc\u80fa\u57fa\u5316\u53cd\u5e94\u53ef\u540c\u65f6\u6784\u5efa\u4e24\u4e2a\u65b0\u7684C-N\u952e\uff0c\u53ef\u4f5c\u4e3a\u5408\u6210\u542b\u6c2e\u6742\u73af\u5316\u5408\u7269\u7684\u6709\u6548\u65b9\u6cd5\u3002 \u4e3a\u4e86\u9a8c\u8bc1\u65b9\u6848\u7684\u53ef\u884c\u6027\uff0c\u4f5c\u8005\u4ee52-\u7898\u82ef\u4e59\u70ef9a\u4e3a\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u5432\u54da\u7684\u5408\u6210\uff08Scheme 2\uff09\u3002\u9996\u5148\uff0c9a\u4e0e\u94af\u50ac\u5316\u5242\u6c27\u5316\u52a0\u6210\u751f\u6210\u4e2d\u95f4\u4f5310\u3002\u4e2d\u95f4\u4f5310\u82e5\u901a\u8fc7\u70ef\u4e19\u57faC-H\u952e\u7684\u6d3b\u5316\uff0c\u5219\u53ef\u5f62\u6210\u94af\u73af\u4e2d\u95f4\u4f5311\uff0c\u518d\u4e0e\u4e8c\u53d4\u4e01\u57fa\u4e8c\u6c2e\u4e19\u5576\u916e\uff081\uff09\u53cd\u5e94\uff0c\u751f\u6210\u4e8c\u6c22\u5432\u54da12\uff0c\u6700\u540e\u901a\u8fc7\u82b3\u6784\u5316\u83b7\u5f97\u5432\u54da14\uff08path a\uff09\u3002\u5176\u6b21\uff0c\u4e2d\u95f4\u4f5310\u82e5\u901a\u8fc7\u4e59\u70ef\u57faC-H\u952e\u7684\u6d3b\u5316\uff0c\u5219\u53ef\u5f62\u6210\u94af\u73af\u4e2d\u95f4\u4f5313\uff0c\u518d\u4e0e\u4e8c\u53d4\u4e01\u57fa\u4e8c\u6c2e\u4e19\u5576\u916e\uff081\uff09\u53cd\u5e94\uff0c\u5219\u53ef\u76f4\u63a5\u83b7\u5f97\u5432\u54da14\uff08path b\uff09\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u4ee52-\u7898\u82ef\u4e59\u70ef9a\u548c\u4e8c\u53d4\u4e01\u57fa\u4e8c\u6c2e\u4e19\u5576\u916e1\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u4e86\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u7b5b\u9009\uff08Table 1\uff09\u3002\u53cd\u5e94\u6700\u4f73\u6761\u4ef6\u4e3a\uff1a\u4ee55 mol\uff05\u7684Pd(PPh3)4\u4e3a\u50ac\u5316\u5242\uff0c5 mol\uff05\u7684PivOH\u4e3a\u6dfb\u52a0\u5242\uff0cCs2CO3\uff082.0\u5f53\u91cf\uff09\u4e3a\u78b1\uff0c\u5728\u7532\u82ef\u6eb6\u5242\u4e2d100 \u00b0C\u53cd\u5e9448 h\uff0c\u5373\u53ef\u83b7\u5f9791%\u6536\u7387\u7684\u5432\u54da\u4ea7\u726914a\u3002 \u4e3a\u4e86\u8fdb\u4e00\u6b65\u4e86\u89e3\u53cd\u5e94\u7684\u673a\u7406\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u6c18\u4ee3\u5b9e\u9a8c\uff08Scheme 3\uff09\u30029a’\u5728\u6807\u51c6\u6761\u4ef6\u4e0b\u53cd\u5e94\uff0c\u83b7\u5f9752\uff05\u6536\u7387\u768414a’\uff0c\u5e76\u5728\u5432\u54da\u76842-\u4f4d\u4e0a\u542b\u670997\uff05\u7684D\u30029a\u2033\u5728\u6807\u51c6\u6761\u4ef6\u4e0b\u53cd\u5e94\uff0c\u83b7\u5f9763\uff05\u6536\u7387\u768414a\u2033\uff0c\u5176\u4e2d\u7532\u57fa\u542b\u670993\uff05\u7684D\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u53cd\u5e94\u662f\u901a\u8fc7\u5c06Pd\u6c27\u5316\u52a0\u6210\u81f3\u82b3\u57fa\u7898\u5316\u7269\u5e76\u968f\u540e\u8fdb\u884c\u4e59\u70ef\u57faC-H\u6d3b\u5316\u800c\u9009\u62e9\u6027\u8fdb\u884c\u7684\uff08Scheme 2, path b\uff09\u3002 \u5728\u83b7\u5f97\u4e0a\u8ff0\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u540e\uff0c\u4f5c\u8005\u5f00\u59cb\u5bf92-\u7898\u82ef\u4e59\u70ef\u5e95\u72699\u8fdb\u884c\u4e86\u6269\u5c55\uff08Table 2\uff09\u3002\u5bf9\u4e8e\u4e8c\u53d6\u4ee3\u7684\u672b\u7aef\u70ef\u70c3\uff0c\u5982-Me\u3001-Et\u3001-Bu\u548c-Ph\uff0c\u4ee561-90\uff05\u7684\u6536\u7387\u83b7\u5f97\u5432\u54da14a–14d\u3002\u540c\u65f6\uff0c\u5177\u6709\u4e0d\u540c\u82b3\u57fa\u53d6\u4ee3\u7684\u5e95\u7269\uff0c\u5982-Me\u3001-F\u3001-Cl\u3001-CF3\u7b49\uff0c\u5747\u53ef\u8010\u53d7\uff0c\u4ee560-80\uff05\u7684\u6536\u7387\u5f97\u5230\u76f8\u5e94\u7684\u4ea7\u726914e–14j\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u82e5\u5c06\u7532\u57fa\u53d6\u4ee3\u57fa\u5f15\u5165\u7898\u5316\u7269\u7684\u90bb\u4f4d\u65f6\uff0c\u4ea7\u726914k\u7684\u6536\u7387\u5f88\u4f4e\uff0825\uff05\uff09\uff0c\u53ef\u80fd\u4e0e\u7a7a\u95f4\u4f4d\u963b\u6709\u5173\u3002\u6b64\u5916\uff0c\u5bf9\u4e8e\u4e09\u53d6\u4ee3\u7684\u70ef\u70c3\uff0c\u5747\u53ef\u987a\u5229\u53cd\u5e94\uff0c\u4ee576-96\uff05\u7684\u6536\u7387\u83b7\u5f97\u76f8\u5e94\u7684\u4ea7\u7269141–14n\u3002\u5bf9\u4e8e\u542b\u6709\u73af\u72b6\u70ef\u70c39o\u3001\u5494\u5511\u57fa14p\u548c\u567b\u5429\u57fa9q\u5e95\u7269\uff0c\u5747\u53ef\u8010\u53d7\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u4ea7\u726914o–14p\u3002\u7136\u800c\uff0c\u542b\u6709\u544b\u5583\u57fa\u7684\u5e95\u7269\u672a\u53d1\u751f\u53cd\u5e94\u3002 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A.; Wang, Q.; Zhu, Y.; Zheng, H.; Peng, X.;\u00a0Cornwall, R. G.; Shi, Y. Pd(0)-Catalyzed Sequential C-N Bond\u00a0Formation via Allylic and Aromatic C-H Amination of \u03b1-Methylstyrenes with Diaziridinone.\u00a0Org. 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