{"id":39509,"date":"2021-08-02T08:00:26","date_gmt":"2021-08-02T00:00:26","guid":{"rendered":"\/\/www.gsbet888.com\/?p=39509"},"modified":"2021-08-02T00:39:39","modified_gmt":"2021-08-01T16:39:39","slug":"%e5%90%b4%e6%9d%b0-%e4%b8%96%e7%95%8c%e8%91%97%e5%90%8d%e5%8c%96%e5%ad%a6%e5%ae%b6","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/2021\/08\/%e5%90%b4%e6%9d%b0-%e4%b8%96%e7%95%8c%e8%91%97%e5%90%8d%e5%8c%96%e5%ad%a6%e5%ae%b6.html","title":{"rendered":"\u5434\u6770"},"content":{"rendered":"<p><strong>\u672c\u6587\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a<\/strong><\/p>\n<h4><strong>\u6982\u8981<\/strong><\/h4>\n<p>\u5434\u6770\uff1a\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66 (National University of Singapore)\u52a9\u7406\u6559\u6388<\/p>\n<p>\u8bfe\u9898\u7ec4\u4e3b\u9875\uff1a<a href=\"https:\/\/www.wujiegroupnus.com\/\">https:\/\/www.wujiegroupnus.com\/<\/a><\/p>\n<h4><strong>\u7ecf\u5386<\/strong><\/h4>\n<p>2002-2006 \u5317\u4eac\u5e08\u8303\u5927\u5b66\uff0c\u5316\u5b66\u7cfb\uff0c\u5b66\u58eb<\/p>\n<p>2006-2012 Boston\u5927\u5b66\uff0c\u5316\u5b66\u7cfb\uff0c\u535a\u58eb\uff08Prof. J. S. Panek\uff09\uff1b<\/p>\n<p>2012-2015 MIT (Massachusetts Institute of Technology)\uff0c\u535a\u58eb\u540e\uff08Prof. T. F. Jamison and T. A. Hatton\uff09\uff1b<\/p>\n<p>2015-2015 Snapdragon Chemistry, Inc. Boston, Senior research scientist<\/p>\n<p>2015-\u81f3\u4eca \u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\uff0c\u52a9\u7406\u6559\u6388<\/p>\n<h4>\u8363\u8a89\u4e0e\u5956\u52b1<\/h4>\n<p>The Distinguished Lectureship Award, The CSJ Asian International Symposium,<\/p>\n<p>The Chemical Society of Japan, 2020<\/p>\n<p>Thieme Chemistry Journal Award, 2019<\/p>\n<p>Young Chemist Award, Department of Chemistry, 2018<\/p>\n<p>Asian Core Program Lectureship Award, 2017-2019<\/p>\n<p>4th Green &amp; Sustainable Manufacturing Award, The GSK-Singapore Partnership, 2017<\/p>\n<p>Skol Tech Postdoctoral Fellow, Massachusetts Institute of Technology, 2013-2014<\/p>\n<h4><strong>\u7814\u7a76\u65b9\u5411<\/strong><\/h4>\n<p>\u5434\u6770\u6559\u6388\u5c0f\u7ec4\u76ee\u524d\u4e3b\u8981\u4ece\u4e8b\u4e24\u65b9\u9762\u7684\u7814\u7a76\uff0c\u5747\u57fa\u4e8e\u6d41\u52a8\u5408\u6210\u6280\u672f\u3002\u4e3b\u8981\u6d89\u53ca\uff1a1)\u91c7\u7528\u5fae\u6d41\u7ba1\u53cd\u5e94\u5668 (micro-tubing reactor)\u4ee5\u53ca\u5f00\u53d1\u65b0\u7684\u53cd\u5e94\u5668\u6a21\u5f0f\uff0c\u8fdb\u800c\u5b9e\u73b0\u5728\u5e38\u89c4\u53cd\u5e94\u91dc\u5185\u8f83\u96be\u5b9e\u73b0\u7684\u53cd\u5e94\uff0c\u4f8b\u5982\uff0c\u6d89\u53ca\u4e00\u7cfb\u5217\u4e0d\u540c\u6c14\u4f53\u53c2\u4e0e\u7684\u53cd\u5e94\u4ee5\u53ca\u5149\u7167\u6761\u4ef6\u4e0b\u7684\u53cd\u5e94\u7b49\uff1b2) \u91c7\u7528\u6d41\u52a8\u6280\u672f\u5b9e\u73b0\u5408\u6210\u7684\u81ea\u52a8\u5316\uff0c\u8fdb\u800c\u5b9e\u73b0\u6709\u673a\u5206\u5b50\u76843D\u6253\u5370\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/ce6e2814f207c9333f10785606c57df3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-39516 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/ce6e2814f207c9333f10785606c57df3-680x402.png\" alt=\"\" width=\"680\" height=\"402\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/ce6e2814f207c9333f10785606c57df3-680x402.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/ce6e2814f207c9333f10785606c57df3-300x177.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/ce6e2814f207c9333f10785606c57df3.png 764w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p><strong>1<\/strong><strong>\uff09\u505c\u6d41\u5fae\u578b\u7ba1\uff08<\/strong><strong>SFMT<\/strong><strong>\uff09\u53cd\u5e94\u5668\u7684\u5f00\u53d1<\/strong><\/p>\n<p>\u5c3d\u7ba1\u8fde\u7eed\u6d41\u52a8\u53cd\u5e94\u5668\u5bf9\u4e8e\u5de5\u4e1a\u53cd\u5e94\u8fc7\u7a0b\u5341\u5206\u6709\u6548\uff0c\u7136\u800c\uff0c\u5c06\u5176\u5e94\u7528\u4e8e\u53cd\u5e94\u5f00\u53d1\u6216\u4f18\u5316\u65f6\uff0c\u5219\u5b58\u5728\u8f83\u5927\u7684\u5c40\u9650\u6027\uff1a(1) \u8fde\u7eed\u6d41\u52a8\u5408\u6210\u6280\u672f (continuous-flow technology)\u5bf9\u4e8e\u53cd\u5e94\u8bd5\u5242\u3001\u50ac\u5316\u5242\u4ee5\u53ca\u6eb6\u5242\u7b49\u53cd\u5e94\u53c2\u6570\u7684\u7b5b\u9009\u8f83\u4e3a\u56f0\u96be\uff1b(2) \u6bcf\u4e00\u6b21\u5b9e\u9a8c\u4e2d\uff0c\u4ec5\u80fd\u591f\u5b8c\u6210\u4e00\u6b21\u53cd\u5e94\u6761\u4ef6\u7684\u7b5b\u9009\u3002\u56e0\u6b64\uff0c\u5bf9\u4e8e\u5e73\u884c\u53cd\u5e94\u7684\u6761\u4ef6\u7b5b\u9009\u8f83\u4e3a\u8017\u65f6\uff1b(3) \u7531\u4e8e\u53cd\u5e94\u7ba1\u8def\u7684\u5bb9\u79ef\u9650\u5236\uff0c\u56e0\u6b64\uff0c\u505c\u7559\u65f6\u95f4 (residence time)\u4e0d\u5b9c\u8fc7\u957f\u3002\u4e3a\u89e3\u51b3\u4e0a\u8ff0\u8fde\u7eed\u6d41\u52a8\u53cd\u5e94\u5668\u4e2d\u5b58\u5728\u7684\u5c40\u9650\u6027\uff0c\u5434\u6770\u6559\u6388\u5c0f\u7ec4\u5f00\u53d1\u51fa\u4e00\u79cd\u91c7\u7528\u5fae\u578b\u7ba1\u8def\u53cd\u5e94\u5668\u8fdb\u884c\u53cd\u5e94\u7b5b\u9009\u7684\u7406\u60f3\u7684\u5e73\u53f0\uff0c\u5e76\u5b9a\u4e49\u4e3a\uff1a\u201c\u505c\u6d41\u201d\u5fae\u578b\u7ba1\u8def\u53cd\u5e94\u5668<sup>[<\/sup><sup>1]-[2<\/sup><sup>]\u00a0 <\/sup>(\u201cStop-Flow\u201dMicro-Tubing reactor, SFMT \u53cd\u5e94\u5668) (Fig. 1\u4e0eFig. 2)\u3002SFMT \u53cd\u5e94\u5668\u5de7\u5999\u5730\u5c06\u8fde\u7eed\u6d41\u52a8\u53cd\u5e94\u5668\u4e0e\u4f20\u7edf\u7684\u95f4\u6b47\u5f0f\u53cd\u5e94\u5668 (batch reactor)\u6709\u6548\u7ed3\u5408\uff0c\u8fdb\u800c\u6210\u529f\u89e3\u51b3\u4e24\u79cd\u53cd\u5e94\u5668\u4e2d\u5b58\u5728\u7684\u5c40\u9650\u6027\uff0c\u5e76\u4e14\u8be5\u53cd\u5e94\u5668\u5df2\u7ecf\u6210\u529f\u5e94\u7528\u4e8e\u6d89\u53ca\u6c14\u4f53\u53c2\u4e0e\u7684\u76f8\u5173\u53cd\u5e94\u4ee5\u53ca\u5149\u5a92\u4ecb\u53cd\u5e94\u7684\u7b5b\u9009<sup>[<\/sup><sup>3]-[6<\/sup><sup>]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/7f88dbbcaa77a1d28f1e88164d4f6dcd.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-39520 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/7f88dbbcaa77a1d28f1e88164d4f6dcd.png\" alt=\"\" width=\"573\" height=\"241\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/7f88dbbcaa77a1d28f1e88164d4f6dcd.png 573w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/7f88dbbcaa77a1d28f1e88164d4f6dcd-300x126.png 300w\" sizes=\"(max-width: 573px) 100vw, 573px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Fig. 1 \u505c\u6d41\u5fae\u578b\u7ba1\uff08SFMT\uff09\u53cd\u5e94\u7ba1<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/4e9a0ba2491dfdebf5689563327de8ce.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-39522 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/4e9a0ba2491dfdebf5689563327de8ce.gif\" alt=\"\" width=\"556\" height=\"316\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Fig. 2 SFMT\u53cd\u5e94\u5668\u7684\u64cd\u4f5c\u7cfb\u7edf<\/p>\n<p><iframe loading=\"lazy\" src=\"https:\/\/v.qq.com\/txp\/iframe\/player.html?vid=a326519rk8c\" width=\"100%\" height=\"360\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><span data-mce-type=\"bookmark\" style=\"display: inline-block; width: 0px; overflow: hidden; line-height: 0;\" class=\"mce_SELRES_start\">\ufeff<\/span><\/iframe><\/p>\n<p>SFMT\u53cd\u5e94\u5668\u7684\u89c6\u9891<\/p>\n<p><strong>2<\/strong><strong>\uff09\u5149\u5a92\u4ecb\u4fc3\u8fdb\u7684\u91c7\u7528\u5929\u7136\u6c14\u539f\u6599\u8fdb\u884c\u7684\u7cbe\u7ec6\u5316\u5b66\u54c1\u5408\u6210<\/strong><\/p>\n<p>\u5929\u7136\u6c14\u4f53\u539f\u6599 (natural gas feedstock)\uff0c\u4f8b\u5982\u4e8c\u6c27\u5316\u78b3\uff0c\u4e59\u7094\uff0c\u4e59\u70ef\u4ee5\u53ca\u4e59\u70f7\u7b49\u5177\u6709\u5ec9\u4ef7\u6613\u5f97\u3001\u6e05\u6d01\u73af\u4fdd\u3001\u65e0\u6bd2\u7b49\u4f18\u52bf\uff0c\u662f\u5341\u5206\u7406\u60f3\u7684\u5316\u5de5\u539f\u6599\u3002\u91c7\u7528\u5929\u7136\u6c14\u539f\u6599\u5408\u6210\u9ad8\u9644\u52a0\u503c\u7684\u5316\u5b66\u54c1\u4e00\u76f4\u5907\u53d7\u5173\u6ce8\uff0c\u5e76\u4e14\uff0c\u7b26\u5408\u56fd\u5bb6\u201c\u78b3\u4e2d\u5408\u201d\u7684\u957f\u671f\u76ee\u6807\u3002\u76ee\u524d\uff0c\u73b0\u6709\u7684\u5929\u7136\u6c14\u539f\u6599\u7684\u50ac\u5316\u8f6c\u5316\u65b9\u6cd5\uff0c\u5219\u5b58\u5728\u53cd\u5e94\u6761\u4ef6\u82db\u523b\u3001\u5b9e\u9a8c\u8bbe\u5907\u6602\u8d35\u3001\u64cd\u4f5c\u590d\u6742\u7b49\u5f0a\u7aef\uff0c\u5728\u7cbe\u7ec6\u5316\u5b66\u54c1\u5f00\u53d1\u4e2d\u7684\u5e94\u7528\u7814\u7a76\u4ecd\u5177\u6709\u8f83\u5927\u7684\u6311\u6218\u6027\uff0c\u5c24\u5176\u5bf9\u4e8e\u6d89\u53ca\u9ad8\u538b\u4ee5\u53ca\u5149\u5a92\u4ecb\u4fc3\u8fdb\u7684\u8f6c\u5316\u8fc7\u7a0b\u3002\u81ea2017\u5e74\u4ee5\u6765\uff0c\u5434\u6770\u6559\u6388\u5c0f\u7ec4\u6210\u529f\u5f00\u53d1\u51fa\u4e00\u7cfb\u5217\u5168\u65b0\u7684\u5408\u6210\u8f6c\u5316\u65b9\u6cd5\u5b66\uff0c\u80fd\u591f\u5728\u53ef\u89c1\u5149\u6761\u4ef6\u4e0b\u91c7\u7528SFMT\u6216\u8fde\u7eed\u6d41\u53cd\u5e94\u5668\uff0c\u5c06\u5ec9\u4ef7\u6613\u5f97\u7684\u6c14\u6001\u539f\u6599\u76f4\u63a5\u8f6c\u5316\u4e3a\u4e00\u7cfb\u5217\u5177\u6709\u9ad8\u9644\u52a0\u503c\u7684\u7cbe\u7ec6\u5316\u5b66\u54c1 (fine chemicals) (Fig. 3)\u3002\u5434\u6770\u6559\u6388\u53d1\u5c55\u7684\u76f8\u5173\u5408\u6210\u8f6c\u5316\u65b9\u6cd5\u5b66\u4e3b\u8981\u6d89\u53ca\uff1a(i) \u91c7\u7528\u4e59\u7094\u6c14\u4f53\u5bf9\u82b3\u5364\u8fdb\u884c\u7684\u4e59\u70ef\u57fa\u5316\u53cd\u5e94<sup>[<\/sup><sup>1<\/sup><sup>]<\/sup>\uff0c(ii) \u901a\u8fc7\u53ef\u89c1\u5149\u9a71\u52a8\u7684\u7094\u57fa\u5316\u5408\u7269\u4e0e\u4e8c\u6c27\u5316\u78b3<sup>[<\/sup><sup>7]-[8<\/sup><sup>]<\/sup>\u4e4b\u95f4\u7684\u6c22\u7fa7\u5316 (hydrocarboxylation)\u4e0e\u78b3\u7fa7\u5316 (carbocarboxylation)\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u5e76\u5c06\u5176\u8fdb\u4e00\u6b65\u5e94\u7528\u4e8e\u836f\u5b66\u7814\u7a76\u4e2d\u8f83\u4e3a\u91cd\u8981\u7684\u6742\u73af\u5206\u5b50\uff0c\u4f8b\u5982\u9999\u8c46\u7d20\uff0c\u55b9\u8bfa\u916e\u7b49\u7684\u6784\u5efa\uff1b(iii) \u5149\u5a92\u4ecb\u4fc3\u8fdb\u7684\u8102\u80aa\u65cfC-H\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[<\/sup><sup>3<\/sup><sup>]<\/sup>\uff1b(iv) \u5728\u65e0\u91d1\u5c5e\u8bd5\u5242\u5b58\u5728\u7684\u6761\u4ef6\u4e0b\uff0c\u9009\u62e9\u53ef\u89c1\u5149\u5a92\u4ecb\uff0c\u91c7\u7528\u4e8c\u6c27\u5316\u78b3\u4ee5\u53ca\u5e26\u6709Si-H\u4e0eC(Sp<sup>3<\/sup>)-H\u952e\u7684\u539f\u6599\uff0c\u8fdb\u884c\u7684\u4e00\u7cfb\u5217\u70ef\u57fa\u5316\u5408\u7269\u7684\u53cc\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[<\/sup><sup>8<\/sup><sup>]<\/sup>\uff1b(v) \u5149\u5a92\u4ecb\u4fc3\u8fdb\u7684\u70f7\u70c3\u4e0e\u7f3a\u7535\u5b50\u70ef\u57fa\u5316\u5408\u7269\u4e4b\u95f4\u7684\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[5<\/sup><sup>]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/b14210e1ee30421b0a34b345c1768a63.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-39526 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/b14210e1ee30421b0a34b345c1768a63-680x552.png\" alt=\"\" width=\"680\" height=\"552\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/b14210e1ee30421b0a34b345c1768a63-680x552.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/b14210e1ee30421b0a34b345c1768a63-300x243.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/b14210e1ee30421b0a34b345c1768a63-768x623.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/b14210e1ee30421b0a34b345c1768a63.png 827w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Fig. 3 \u5149\u5a92\u4ecb\u4fc3\u8fdb\u7684\u91c7\u7528\u5929\u7136\u6c14\u539f\u6599\u7684\u7cbe\u7ec6\u5316\u5b66\u54c1\u5408\u6210<\/p>\n<p><strong>3<\/strong><strong>\uff09\u5149\u5a92\u4ecb\u4fc3\u8fdb\u7684<\/strong><strong>C-H<\/strong><strong>\u4e0e<\/strong><strong>Si-H<\/strong><strong>\u5b98\u80fd\u56e2\u5316<\/strong><\/p>\n<p>\u81ea\u4e0a\u4e16\u7eaa70\u5e74\u4ee3\u4ee5\u6765\uff0cC-H\u7684\u76f4\u63a5\u8f6c\u5316\u4e00\u76f4\u5907\u53d7\u5173\u6ce8\u3002\u7531\u4e8eC-H\u7684\u76f4\u63a5\u5b98\u80fd\u56e2\u5316\u65b9\u6cd5\u5b66\u4e0d\u4ec5\u7b26\u5408\u7eff\u8272\u4e0e\u53ef\u6301\u7eed\u5408\u6210\u7684\u8bbe\u8ba1\u7406\u5ff5\uff0c\u5e76\u4e14\uff0cC-H\u952e\u5e7f\u6cdb\u5b58\u5728\u4e8e\u4e00\u7cfb\u5217\u4e0d\u540c\u7c7b\u578b\u7684\u6709\u673a\u5206\u5b50\u4e2d\u3002\u76ee\u524d\uff0c\u5316\u5b66\u5bb6\u7684\u76f8\u5173\u7814\u7a76\u5de5\u4f5c\u4e3b\u8981\u5173\u6ce8\u4e8eC(sp<sup>2<\/sup>)-H\u952e\u7684\u6d3b\u5316\uff0c\u8fdb\u800c\u5f00\u53d1\u51fa\u4e00\u7cfb\u5217\u6784\u5efa\u6709\u673a\u5206\u5b50\u7684\u5168\u65b0\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u5bf9\u4e8eC(sp<sup>3<\/sup>)-H\u952e\u7684\u6d3b\u5316\u7684\u7814\u7a76\uff0c\u5219\u8f83\u5c11\u6709\u6587\u732e\u62a5\u9053\u3002\u8fd9\u91cc\uff0c\u5434\u6770\u6559\u6388\u5c0f\u7ec4\u53d1\u73b0\uff0c\u4e2d\u6027\u66d9\u7ea2Y (neutral eosin Y)<sup>[<\/sup><sup>9]-[11<\/sup><sup>]<\/sup>\u5728\u53ef\u89c1\u5149\u6761\u4ef6\u4e0b\u6d3b\u5316\u4e4b\u540e\uff0c\u80fd\u591f\u4f5c\u4e3a\u7406\u60f3\u7684HAT (hydrogen atom transfer)\u5149\u50ac\u5316\u5242<sup>[<\/sup><sup>12<\/sup><sup>]<\/sup>\uff0c\u8fdb\u800c\u987a\u5229\u53c2\u4e0e\u4e00\u7cfb\u5217C-H<sup>[<\/sup><sup>12]-[15<\/sup><sup>]<\/sup>\u4e0eSi-H\u952e\u7684\u5b98\u80fd\u56e2\u5316\u3002\u540c\u65f6\uff0c\u7531\u4e8e\u8fd9\u4e00\u53cd\u5e94\u7b56\u7565\u4e2d\u65e0\u9700\u5916\u52a0\u91d1\u5c5e\u8bd5\u5242\uff0c\u5e76\u4e14\u4e2d\u6027\u66d9\u7ea2Y\u5177\u6709\u5ec9\u4ef7\u6613\u5f97\u4ee5\u53ca\u4f18\u826f\u7684\u50ac\u5316\u6548\u7387\u7b49\u4f18\u52bf\uff0c\u56e0\u800c\uff0c\u5728\u5149\u50ac\u5316\u6761\u4ef6\u4e0b\uff0c\u91c7\u7528\u4e2d\u6027\u66d9\u7ea2Y\u4fc3\u8fdb\u7684C-H\u4e0eSi-H\u5b98\u80fd\u56e2\u5316\u65b9\u6cd5\u5b66\uff0c\u5df2\u7ecf\u6210\u4e3a\u5b9e\u9a8c\u64cd\u4f5c\u6700\u4e3a\u65b9\u4fbf\uff0c\u5e76\u7b26\u5408\u7eff\u8272\u5316\u5b66\u8981\u6c42\u7684\u4e00\u79cd\u5168\u65b0\u7684\u53cd\u5e94\u7b56\u7565\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/de5bcf7d8eaea98b5a67b2b3883c44b3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-39529 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/de5bcf7d8eaea98b5a67b2b3883c44b3-680x432.png\" alt=\"\" width=\"680\" height=\"432\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/de5bcf7d8eaea98b5a67b2b3883c44b3-680x432.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/de5bcf7d8eaea98b5a67b2b3883c44b3-300x190.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/de5bcf7d8eaea98b5a67b2b3883c44b3-768x488.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/07\/de5bcf7d8eaea98b5a67b2b3883c44b3.png 868w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Fig. 4 \u5149\u5a92\u4ecb\u7684C-H\u4e0eSi-H\u5b98\u80fd\u56e2\u5316<\/p>\n<h4><strong>\u76f8\u5173\u94fe\u63a5<\/strong><\/h4>\n<p><a href=\"https:\/\/www.x-mol.com\/news\/14687\">\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u5434\u6770\u535a\u58eb\u8bfe\u9898\u7ec4\u8fd1\u5e74\u6765\u5de5\u4f5c\u8fdb\u5c55<\/a><\/p>\n<p><a href=\"https:\/\/www.x-mol.com\/news\/636659\">NUS\u5434\u6770\u8bfe\u9898\u7ec4Nat. Chem.\uff1a\u8fde\u7eed\u6d41\u5408\u6210\u4e0e\u56fa\u76f8\u5408\u6210\u76f8\u7ed3\u5408\u5b9e\u73b0\u5c0f\u5206\u5b50\u836f\u7269\u7684\u81ea\u52a8\u5316\u5408\u6210\u4e0e\u884d\u751f<\/a><\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<ol>\n<li>F. Xue, H. Deng, C. Xue, D. K. B. Mohamed, K. Y. Tang, J. Wu, <em>Chem. Sci. <\/em><strong>2017, <\/strong><em>8<\/em>, 3623. doi: <a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2017\/SC\/C7SC00408G#!divAbstract\">10.1039\/C7SC00408G.<\/a><\/li>\n<li>R. W. Au-Toh, J. S. Au-Li, J. Au-Wu, <em>JoVE <\/em><strong>2018,<\/strong> 131, e56897. doi: <a href=\"https:\/\/www.jove.com\/cn\/t\/56897\/utilization-stop-flow-micro-tubing-reactors-for-development-organic\">10.3791\/56897.<\/a><\/li>\n<li>H. Deng, Q. Zhou, J. Wu, <em>Angew. Chem. Int. Ed. <\/em><strong>2018, <\/strong><em>57<\/em>, 12661. doi: <a href=\"https:\/\/doi.org\/10.1002\/anie.201804844.\">10.1002\/anie.201804844.<\/a><\/li>\n<li>J. Li, Y. Luo, H. W. Cheo, Y. Lan, J. Wu, <em>Chem <\/em><strong>2019, <\/strong><em>5<\/em>, 192. doi: <a href=\"https:\/\/doi.org\/10.1016\/j.chempr.2018.10.006.\">10.1016\/j.chempr.2018.10.006.<\/a><\/li>\n<li>P. Jia, Q. Li, W. C. Poh, H. Jiang, H. Liu, H. Deng, J. Wu, <em>Chem <\/em><strong>2020, <\/strong><em>6<\/em>, 1766. doi: <a href=\"https:\/\/doi.org\/10.1016\/j.chempr.2020.04.022.\">10.1016\/j.chempr.2020.04.022.<\/a><\/li>\n<li>C. Liu, J. Xie, W. Wu, M. Wang, W. Chen, S. B. Idres, J. Rong, L. Deng, S. A. Khan, J. Wu, <em>Nat. Chem. <\/em><strong>2021, <\/strong><em>13<\/em>, 451. doi: <a href=\"https:\/\/www.nature.com\/articles\/s41557-021-00662-w\">10.1038\/s41557-021-00662-w.<\/a><\/li>\n<li>J. Hou, A. Ee, W. Feng, J. Xu, Y. Zhao, J. Wu, <em>J. Am. Chem. Soc. <\/em><strong>2018, <\/strong><em>140<\/em>, 5257. doi: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.8b01561\">10.1021\/jacs.8b01561.<\/a><\/li>\n<li>J. Hou, A. Ee, H. Cao, H. Ong, J. Xu, J. Wu, <em>Angew. Chem. Int. Ed. <\/em><strong>2018, <\/strong><em>57<\/em>, 17220. doi: <a href=\"https:\/\/doi.org\/10.1002\/anie.201811266.\">10.1002\/anie.201811266.<\/a><\/li>\n<li>X. Fan, J. Rong, H. Wu, Q. Zhou, H. Deng, J. Tan, C. Xue, L. Wu, H. Tao, J.Wu, <em>Angew. Chem. Int. Ed. <\/em><strong>2018, <\/strong><em>57<\/em>, 8514. doi: <a href=\"https:\/\/doi.org\/10.1002\/anie.201803220.\">10.1002\/anie.201803220.<\/a><\/li>\n<li>J. Yan, H. W. Cheo, W. K. Teo, X. Shi, H. Wu, S. B. Idres, L. Deng, J. Wu, <em>J. Am. Chem. Soc. <\/em><strong>2020, <\/strong><em>142<\/em>, 11357. doi: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.0c02052\">10.1021\/jacs.0c02052.<\/a><\/li>\n<li>Y. Kuang, K. Wang, X. Shi, X. Huang, E. Meggers, J. Wu, <em>Angew. Chem. Int. Ed. <\/em><strong>2019, <\/strong><em>58<\/em>, 16859. doi: <a href=\"https:\/\/doi.org\/10.1002\/anie.201910414.\">10.1002\/anie.201910414.<\/a><\/li>\n<li>R. Zhou, Y. Y. Goh, H. Liu, H. Tao, L. Li, J. Wu, <em>Angew. Chem. Int. Ed. <\/em><strong>2017, <\/strong><em>56<\/em>, 16621. doi: <a href=\"https:\/\/doi.org\/10.1002\/anie.201711250.\">10.1002\/anie.201711250.<\/a><\/li>\n<li>R. Zhou, H. Liu, H. Tao, X. Yu, J. Wu, <em>Chem. Sci. <\/em><strong>2017, <\/strong><em>8<\/em>, 4654. doi: <a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2017\/SC\/C7SC00953D#!divAbstract\">10.1039\/C7SC00953D.<\/a><\/li>\n<li>H. Liu, L. Ma, R. Zhou, X. Chen, W. Fang, J. Wu, <em>ACS Catal. <\/em><strong>2018, <\/strong><em>8<\/em>, 6224. doi: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acscatal.8b00481\">10.1021\/acscatal.8b00481.<\/a><\/li>\n<li>H. Deng, X. Fan, Z. Chen, Q. Xu, J. Wu, <em>J. Am. Chem. Soc. <\/em><strong>2017, <\/strong><em>139<\/em>, 13579. doi: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.7b08158\">10.1021\/jacs.7b08158.<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a \u6982\u8981 \u5434\u6770\uff1a\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66 (National University of Singapore)\u52a9\u7406\u6559\u6388 \u8bfe\u9898\u7ec4\u4e3b\u9875\uff1ahttps:\/\/www.wujiegroupnus.com\/ \u7ecf\u5386 2002-2006 \u5317\u4eac\u5e08\u8303\u5927\u5b66\uff0c\u5316\u5b66\u7cfb\uff0c\u5b66\u58eb 2006-2012 Boston\u5927\u5b66\uff0c\u5316\u5b66\u7cfb\uff0c\u535a\u58eb\uff08Prof. J. S. Panek\uff09\uff1b 2012-2015 MIT (Massachusetts Institute of Technology)\uff0c\u535a\u58eb\u540e\uff08Prof. T. F. Jamison and T. A. Hatton\uff09\uff1b 2015-2015 Snapdragon Chemistry, Inc. Boston, Senior research scientist 2015-\u81f3\u4eca \u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\uff0c\u52a9\u7406\u6559\u6388 \u8363\u8a89\u4e0e\u5956\u52b1 The Distinguished Lectureship Award, The CSJ Asian International Symposium, The Chemical Society of Japan, 2020 Thieme Chemistry Journal Award, 2019 Young Chemist Award, Department of Chemistry, 2018 Asian Core Program Lectureship Award, 2017-2019 4th Green &amp; Sustainable Manufacturing Award, The GSK-Singapore Partnership, 2017 Skol Tech Postdoctoral Fellow, Massachusetts Institute of Technology, 2013-2014 \u7814\u7a76\u65b9\u5411 \u5434\u6770\u6559\u6388\u5c0f\u7ec4\u76ee\u524d\u4e3b\u8981\u4ece\u4e8b\u4e24\u65b9\u9762\u7684\u7814\u7a76\uff0c\u5747\u57fa\u4e8e\u6d41\u52a8\u5408\u6210\u6280\u672f\u3002\u4e3b\u8981\u6d89\u53ca\uff1a1)\u91c7\u7528\u5fae\u6d41\u7ba1\u53cd\u5e94\u5668 (micro-tubing reactor)\u4ee5\u53ca\u5f00\u53d1\u65b0\u7684\u53cd\u5e94\u5668\u6a21\u5f0f\uff0c\u8fdb\u800c\u5b9e\u73b0\u5728\u5e38\u89c4\u53cd\u5e94\u91dc\u5185\u8f83\u96be\u5b9e\u73b0\u7684\u53cd\u5e94\uff0c\u4f8b\u5982\uff0c\u6d89\u53ca\u4e00\u7cfb\u5217\u4e0d\u540c\u6c14\u4f53\u53c2\u4e0e\u7684\u53cd\u5e94\u4ee5\u53ca\u5149\u7167\u6761\u4ef6\u4e0b\u7684\u53cd\u5e94\u7b49\uff1b2) \u91c7\u7528\u6d41\u52a8\u6280\u672f\u5b9e\u73b0\u5408\u6210\u7684\u81ea\u52a8\u5316\uff0c\u8fdb\u800c\u5b9e\u73b0\u6709\u673a\u5206\u5b50\u76843D\u6253\u5370\u3002 1\uff09\u505c\u6d41\u5fae\u578b\u7ba1\uff08SFMT\uff09\u53cd\u5e94\u5668\u7684\u5f00\u53d1 \u5c3d\u7ba1\u8fde\u7eed\u6d41\u52a8\u53cd\u5e94\u5668\u5bf9\u4e8e\u5de5\u4e1a\u53cd\u5e94\u8fc7\u7a0b\u5341\u5206\u6709\u6548\uff0c\u7136\u800c\uff0c\u5c06\u5176\u5e94\u7528\u4e8e\u53cd\u5e94\u5f00\u53d1\u6216\u4f18\u5316\u65f6\uff0c\u5219\u5b58\u5728\u8f83\u5927\u7684\u5c40\u9650\u6027\uff1a(1) \u8fde\u7eed\u6d41\u52a8\u5408\u6210\u6280\u672f (continuous-flow technology)\u5bf9\u4e8e\u53cd\u5e94\u8bd5\u5242\u3001\u50ac\u5316\u5242\u4ee5\u53ca\u6eb6\u5242\u7b49\u53cd\u5e94\u53c2\u6570\u7684\u7b5b\u9009\u8f83\u4e3a\u56f0\u96be\uff1b(2) \u6bcf\u4e00\u6b21\u5b9e\u9a8c\u4e2d\uff0c\u4ec5\u80fd\u591f\u5b8c\u6210\u4e00\u6b21\u53cd\u5e94\u6761\u4ef6\u7684\u7b5b\u9009\u3002\u56e0\u6b64\uff0c\u5bf9\u4e8e\u5e73\u884c\u53cd\u5e94\u7684\u6761\u4ef6\u7b5b\u9009\u8f83\u4e3a\u8017\u65f6\uff1b(3) \u7531\u4e8e\u53cd\u5e94\u7ba1\u8def\u7684\u5bb9\u79ef\u9650\u5236\uff0c\u56e0\u6b64\uff0c\u505c\u7559\u65f6\u95f4 (residence time)\u4e0d\u5b9c\u8fc7\u957f\u3002\u4e3a\u89e3\u51b3\u4e0a\u8ff0\u8fde\u7eed\u6d41\u52a8\u53cd\u5e94\u5668\u4e2d\u5b58\u5728\u7684\u5c40\u9650\u6027\uff0c\u5434\u6770\u6559\u6388\u5c0f\u7ec4\u5f00\u53d1\u51fa\u4e00\u79cd\u91c7\u7528\u5fae\u578b\u7ba1\u8def\u53cd\u5e94\u5668\u8fdb\u884c\u53cd\u5e94\u7b5b\u9009\u7684\u7406\u60f3\u7684\u5e73\u53f0\uff0c\u5e76\u5b9a\u4e49\u4e3a\uff1a\u201c\u505c\u6d41\u201d\u5fae\u578b\u7ba1\u8def\u53cd\u5e94\u5668[1]-[2]\u00a0 (\u201cStop-Flow\u201dMicro-Tubing reactor, SFMT \u53cd\u5e94\u5668) 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