{"id":40310,"date":"2021-10-06T23:22:28","date_gmt":"2021-10-06T15:22:28","guid":{"rendered":"\/\/www.gsbet888.com\/?p=40310"},"modified":"2021-10-07T00:44:42","modified_gmt":"2021-10-06T16:44:42","slug":"2021%e5%b9%b4%e8%af%ba%e8%b4%9d%e5%b0%94%e5%8c%96%e5%ad%a6%e5%a5%96-%e8%a7%a3%e8%af%bb","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemnews\/2021\/10\/2021%e5%b9%b4%e8%af%ba%e8%b4%9d%e5%b0%94%e5%8c%96%e5%ad%a6%e5%a5%96-%e8%a7%a3%e8%af%bb.html","title":{"rendered":"2021\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956 \u89e3\u8bfb"},"content":{"rendered":"<p>\u4f5c\u8005 \u77f3\u6cb9\u919a<\/p>\n<h4>\u5bfc\u8bfb<\/h4>\n<p>\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u4e8e10\u67086\u65e517\u70b945\u5206\u5728\u745e\u5178\u9996\u90fd\u65af\u5fb7\u54e5\u5c14\u6469\u745e\u5178\u7687\u5bb6\u79d1\u5b66\u9662\u63ed\u6653\uff0c\u8bfa\u8d1d\u5c14\u5956\u59d4\u5458\u4f1a\u5c06\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u6388\u4e88\u5fb7\u56fd\u79d1\u5b66\u5bb6<a href=\"\/\/www.gsbet888.com\/chemists\/2021\/10\/benjamin-list.html\">Benjamin List<\/a>\u548c\u7f8e\u56fd\u79d1\u5b66\u5bb6<a href=\"\/\/www.gsbet888.com\/chemists\/2014\/11\/post-3283.html\">David W.C. MacMillan<\/a>\uff0c\u83b7\u5956\u7406\u7531\uff1a\u56e0\u201c\u5728\u4e0d\u5bf9\u79f0\u6709\u673a\u50ac\u5316\u65b9\u9762\u7684\u53d1\u5c55\uff08for the development of asymmetric organocatalysis\uff09\u201d\uff0c\u4ed6\u4eec\u5f00\u53d1\u7684\u5de5\u5177\u5f7b\u5e95\u6539\u53d8\u4e86\u5206\u5b50\u7684\u7ed3\u6784\u3002(\u56fe 1)\u3002<\/p>\n<div id=\"attachment_40311\" style=\"width: 460px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/ee6df7033a974fd2d6b73e2297a56fc1.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-40311\" class=\"wp-image-40311\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/ee6df7033a974fd2d6b73e2297a56fc1-680x680.png\" alt=\"\" width=\"450\" height=\"450\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/ee6df7033a974fd2d6b73e2297a56fc1-680x680.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/ee6df7033a974fd2d6b73e2297a56fc1-300x300.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/ee6df7033a974fd2d6b73e2297a56fc1-150x150.png 150w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/ee6df7033a974fd2d6b73e2297a56fc1-768x768.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/ee6df7033a974fd2d6b73e2297a56fc1-120x120.png 120w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/ee6df7033a974fd2d6b73e2297a56fc1.png 830w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/a><p id=\"caption-attachment-40311\" class=\"wp-caption-text\">\u56fe 1 2021\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u5f97\u4e3b<\/p><\/div>\n<h4><b>\u83b7\u5956\u7406\u7531<\/b><\/h4>\n<p>\u4f17\u6240\u5468\u77e5\uff0c\u8bb8\u591a\u9886\u57df\u7814\u7a76\u9886\u57df\u548c\u5de5\u4e1a\u90fd\u4f9d\u8d56\u4e8e\u5316\u5b66\u5bb6\u6784\u5efa\u5206\u5b50\u7684\u80fd\u529b\uff0c\u8fd9\u4e9b\u5206\u5b50\u53ef\u4ee5\u5f62\u6210\u5f39\u6027\u548c\u8010\u7528\u7684\u6750\u6599\uff0c\u5c06\u80fd\u91cf\u50a8\u5b58\u5728\u7535\u6c60\u4e2d\u6216\u6291\u5236\u75be\u75c5\u7684\u8fdb\u5c55\u3002\u7136\u800c\u76f8\u5173\u5206\u5b50\u7684\u6784\u5efa\u5c31\u9700\u8981\u50ac\u5316\u5242\uff0c\u50ac\u5316\u5242\u662f\u63a7\u5236\u548c\u52a0\u901f\u53cd\u5e94\u7684\u7269\u8d28\uff0c\u5176\u5e76\u4e0d\u4f1a\u6210\u4e3a\u6700\u7ec8\u4ea7\u7269\u7684\u4e00\u90e8\u5206\u3002\u4f8b\u5982\uff0c\u6c7d\u8f66\u4e2d\u7684\u50ac\u5316\u5242\u5c06\u5e9f\u6c14\u4e2d\u7684\u6709\u6bd2\u7269\u8d28\u8f6c\u5316\u4e3a\u65e0\u5bb3\u5206\u5b50\u3002\u6211\u4eec\u7684\u8eab\u4f53\u4e5f\u542b\u6709\u6570\u4ee5\u5343\u8ba1\u7684\u9176\u5f62\u5f0f\u7684\u50ac\u5316\u5242\uff0c\u5b83\u4eec\u6784\u5efa\u4e86\u751f\u547d\u6240\u5fc5\u9700\u7684\u5206\u5b50\u3002\u7efc\u4e0a\uff0c\u5316\u5b66\u5206\u5b50\u6784\u5efa\u662f\u4e00\u95e8\u5f88\u56f0\u96be\u5e76\u4e14\u8ff7\u4eba\u7684\u827a\u672f\uff0c\u5438\u5f15\u4e86\u4f17\u591a\u5316\u5b66\u5bb6\u4eec\u7684\u773c\u7403\uff0c\u5176\u8003\u8651\u5982\u4f55\u9ad8\u6548\u5feb\u901f\u4fbf\u6377\u7684\u6784\u5efa\u5206\u5b50\u3002\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u5f97\u4e3b\u5c31\u53d1\u5c55\u4e86\u4e00\u79cd\u7eff\u8272\u9ad8\u6548\u7684\u50ac\u5316\u5242\u53bb\u6784\u5efa\u5316\u5b66\u5206\u5b50\u3002<\/p>\n<p><a href=\"\/\/www.gsbet888.com\/chemists\/2021\/10\/benjamin-list.html\"><b>Benjamin List <\/b><\/a><b>\u548c<\/b><a href=\"\/\/www.gsbet888.com\/chemists\/2014\/11\/post-3283.html\"><b> David MacMillan <\/b><\/a><b>\u56e0\u5f00\u53d1\u51fa\u4e00\u79cd\u7cbe\u786e\u7684\u5206\u5b50\u6784\u5efa\u65b0\u5de5\u5177\uff1a<\/b><b> \u201c<\/b><b>\u6709\u673a\u50ac\u5316\u5242<\/b><b>\u201d<\/b><b>\u5e76\u5c06\u5176\u7528\u4e8e\u4e0d\u5bf9\u79f0\u50ac\u5316\u9886\u57df\u800c\u83b7\u5f97<\/b><b> 2021 <\/b><b>\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u3002<\/b>\u8fd9\u5bf9\u836f\u7269\u7814\u7a76\u4ee5\u53ca\u7cbe\u7ec6\u5316\u5b66\u54c1\u4ea7\u751f\u4e86\u5de8\u5927\u5f71\u54cd\uff0c\u5e76\u4e14\u5df2\u7ecf\u6781\u5927\u5730\u9020\u798f\u4e8e\u4eba\u7c7b\u3002\u201d<\/p>\n<h4><b>\u6df1\u5ea6\u89e3\u6790<\/b><\/h4>\n<p>\u50ac\u5316\u5242\u662f\u79d1\u5b66\u5bb6\u4eec\u6b66\u5668\u5e93\u4e2d\u6700\u91cd\u8981\u7684\u6b66\u5668\u4e4b\u4e00\u3002\u4f46\u7814\u7a76\u4eba\u5458\u957f\u671f\u4ee5\u6765\u4e00\u76f4\u8ba4\u4e3a\uff0c\u539f\u5219\u4e0a\u53ea\u6709\u4e24\u79cd\u50ac\u5316\u5242\u53ef\u7528\uff1a\u91d1\u5c5e\u548c\u9176\u3002 <a href=\"\/\/www.gsbet888.com\/chemists\/2021\/10\/benjamin-list.html\">Benjamin List <\/a>\u548c<a href=\"\/\/www.gsbet888.com\/chemists\/2014\/11\/post-3283.html\"> David MacMillan <\/a> \u88ab\u6388\u4e88 2021 \u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\uff0c\u56e0\u4e3a\u4ed6\u4eec\u5728 2000\u5e74\u72ec\u7acb\u5f00\u53d1\u4e86\u7b2c\u4e09\u79cd\u50ac\u5316\u5242\uff0c\u5373\uff1a\u5efa\u7acb\u5728\u6709\u673a\u5c0f\u5206\u5b50\u4e0a\u7684\u4e0d\u5bf9\u79f0\u6709\u673a\u50ac\u5316\u5242\u3002<\/p>\n<p>\u6709\u673a\u50ac\u5316\u5242\u5177\u6709\u4e00\u4e2a\u7a33\u5b9a\u7684\u78b3\u539f\u5b50\u6846\u67b6\uff0c\u66f4\u6d3b\u6cfc\u7684\u5316\u5b66\u57fa\u56e2\u53ef\u4ee5\u9644\u7740\u5728\u78b3\u539f\u5b50\u4e0a\u3002\u8fd9\u4e9b\u57fa\u56e2\u901a\u5e38\u542b\u6709\u6c27\u3001\u6c2e\u3001\u786b\u6216\u78f7\u7b49\u5e38\u89c1\u5143\u7d20\u3002\u8fd9\u610f\u5473\u7740\u8be5\u7c7b\u50ac\u5316\u5242\u65e2\u73af\u4fdd\u4e14\u6210\u672c\u4f4e\u5ec9\u3002\u6709\u673a\u50ac\u5316\u5242\u5e94\u7528\u9886\u57df\u7684\u8fc5\u901f\u6269\u5c55\u4e3b\u8981\u662f\u8be5\u7c7b\u50ac\u5316\u5242\u80fd\u591f\u5728\u4e0d\u5bf9\u79f0\u9886\u57df\u5f88\u597d\u7684\u5e94\u7528\uff0c\u5e76\u4e14\u5bf9\u836f\u7269\u7814\u7a76\u4ee5\u53ca\u7cbe\u7ec6\u5316\u5b66\u54c1\u7684\u4ea7\u751f\u4e86\u5de8\u5927\u5f71\u54cd\u3002\u81ea 2000 \u5e74\u4ee5\u6765\uff0c\u6709\u673a\u50ac\u5316\u4ee5\u60ca\u4eba\u7684\u901f\u5ea6\u53d1\u5c55\u3002<a href=\"\/\/www.gsbet888.com\/chemists\/2021\/10\/benjamin-list.html\">Benjamin List <\/a>\u548c<a href=\"\/\/www.gsbet888.com\/chemists\/2014\/11\/post-3283.html\"> David MacMillan <\/a> \u4ecd\u7136\u662f\u8be5\u9886\u57df\u7684\u9886\u5bfc\u8005\uff0c\u5e76\u8868\u660e\u6709\u673a\u50ac\u5316\u5242\u53ef\u7528\u4e8e\u9a71\u52a8\u591a\u79cd\u5316\u5b66\u53cd\u5e94\u3002\u5229\u7528\u8fd9\u4e9b\u53cd\u5e94\uff0c\u7814\u7a76\u4eba\u5458\u73b0\u5728\u53ef\u4ee5\u66f4\u6709\u6548\u5730\u6784\u5efa\u4ece\u65b0\u836f\u7269\u5230\u53ef\u4ee5\u5728\u592a\u9633\u80fd\u7535\u6c60\u4e2d\u6355\u83b7\u5149\u5b50\u7684\u591a\u79cd\u7269\u8d28\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u5f0f\uff0c\u6709\u673a\u50ac\u5316\u5242\u6b63\u5728\u4e3a\u4eba\u7c7b\u5e26\u6765\u6700\u5927\u7684\u597d\u5904\u3002<\/p>\n<p>\u9176\u7531\u6570\u767e\u79cd\u6c28\u57fa\u9178\u7ec4\u6210\uff0c\u4f46\u901a\u5e38\u53ea\u6709\u5c11\u6570\u6c28\u57fa\u9178\u53c2\u4e0e\u5316\u5b66\u53cd\u5e94\uff0c\u6765\u6784\u5efa\u6211\u4eec\u8eab\u4f53\u4e2d\u91cd\u8981\u7684\u5206\u5b50\u3002 Benjamin List \u6559\u6388\u5f00\u59cb\u6000\u7591\u662f\u5426\u771f\u7684\u9700\u8981\u6574\u4e2a\u9176\u624d\u80fd\u50ac\u5316\u4e00\u4e2a\u5316\u5b66\u53cd\u5e94\u5462\uff1f\u4e0a\u4e2a\u4e16\u7eaa70\u5e74\u4ee3\uff0c\u4f17\u591a\u5316\u5b66\u5bb6\u4f7f\u7528\u812f\u6c28\u9178\u4f5c\u4e3a\u50ac\u5316\u5242\u8fdb\u884c\u4e86\u5927\u91cf\u7684\u7814\u7a76\u3002\u57fa\u4e8e\u6b64\uff0c<a href=\"\/\/www.gsbet888.com\/chemists\/2021\/10\/benjamin-list.html\">Benjamin List <\/a>\u6559\u6388\u6d4b\u8bd5\u4e86\u812f\u6c28\u9178<sup>1<\/sup>\u50ac\u5316\u7f9f\u919b\u7f29\u5408\u53cd\u5e94(Aldol Reaction)(\u56fe 2\u548c\u56fe3)\uff0c\u5c31\u662f\u8fd9\u4e2a\u7b80\u5355\u7684\u5c1d\u8bd5\uff0c\u8bc1\u660e\u4e86\u812f\u6c28\u9178\u662f\u4e00\u79cd\u9ad8\u6548\u7684\u50ac\u5316\u5242\uff0c\u63d0\u51fa\u4e86\u300c\u6709\u673a\u50ac\u5316\u5242\u300d\u6982\u5ff5\uff0c\u5df2\u6210\u4e3a\u6709\u673a\u50ac\u5316\u9886\u57df\u7684\u9f3b\u7956\u3002<\/p>\n<div id=\"attachment_40312\" style=\"width: 690px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/8a68c7643065119a2ccf860543dbbda8.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-40312\" class=\"wp-image-40312 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/8a68c7643065119a2ccf860543dbbda8-680x511.png\" alt=\"\" width=\"680\" height=\"511\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/8a68c7643065119a2ccf860543dbbda8-680x511.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/8a68c7643065119a2ccf860543dbbda8-300x225.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/8a68c7643065119a2ccf860543dbbda8-768x577.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/8a68c7643065119a2ccf860543dbbda8.png 1103w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><p id=\"caption-attachment-40312\" class=\"wp-caption-text\">\u56fe 2 Benjamin List\u7684\u8bbe\u8ba1\u7406\u5ff5<\/p><\/div>\n<div id=\"attachment_40313\" style=\"width: 690px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/cbb95ca7e5e2e428955dcc230ff269c3.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-40313\" class=\"wp-image-40313 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/cbb95ca7e5e2e428955dcc230ff269c3-680x177.jpg\" alt=\"\" width=\"680\" height=\"177\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/cbb95ca7e5e2e428955dcc230ff269c3-680x177.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/cbb95ca7e5e2e428955dcc230ff269c3-300x78.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/cbb95ca7e5e2e428955dcc230ff269c3-768x200.jpg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/cbb95ca7e5e2e428955dcc230ff269c3.jpg 1427w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><p id=\"caption-attachment-40313\" class=\"wp-caption-text\">\u56fe 3 \u812f\u6c28\u9178\u50ac\u5316\u7684Aldol\u53cd\u5e94<\/p><\/div>\n<p>&nbsp;<\/p>\n<p>\u91d1\u5c5e\u50ac\u5316\u5242\u5f88\u5bb9\u6613\u88ab\u6c34\u5206\u4ee5\u53ca\u5176\u4ed6\u56e0\u7d20\u7834\u574f\u3002<a href=\"\/\/www.gsbet888.com\/chemists\/2014\/11\/post-3283.html\">David MacMillan<\/a>\u57fa\u4e8e\u8fd9\u6837\u4e00\u4e2a\u51fa\u53d1\u70b9\u601d\u8003\uff0c\u662f\u5426\u6709\u53ef\u80fd\u5f00\u53d1\u4e00\u79cd\u7b80\u5355\u3001\u5ec9\u4ef7\u4e14\u73af\u4fdd\u50ac\u5316\u5242\u53bb\u9a71\u52a8\u4e0d\u5bf9\u79f0\u53cd\u5e94\u3002\u57fa\u4e8e\u6b64\u60f3\u6cd5\uff0c<a href=\"\/\/www.gsbet888.com\/chemists\/2014\/11\/post-3283.html\">David MacMillan<\/a>\u6559\u6388\u8bbe\u8ba1\u5e76\u5236\u5907\u4e86\u4e00\u79cd\u6709\u673a\u50ac\u5316\u5242<sup>2<\/sup>\uff0c\u5176\u4e8c\u7ea7\u80fa\u90e8\u4f4d\u4e0e\u5e95\u7269\u53cd\u5e94\u5f62\u6210\u4eb2\u7535\u6027\u9ad8\u7684\u4e9a\u80fa\u4e2d\u95f4\u4f53\uff0c\u6781\u5927\u5730\u50ac\u5316\u72c4\u5c14\u65af-\u963f\u5c14\u5fb7\u53cd\u5e94\u7684\u80fd\u529b(\u56fe 4\u548c\u56fe5)\u3002<a href=\"\/\/www.gsbet888.com\/chemists\/2014\/11\/post-3283.html\">David MacMillan<\/a> \u521b\u5236\u51fa\u201c\u6709\u673a\u50ac\u5316\u201d\u4e00\u8bcd\uff0c\u5e76\u63d0\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u6709\u673a\u50ac\u5316\u673a\u7406\u2014\u2014\u4e9a\u80fa\u6d3b\u5316\u3002<\/p>\n<div id=\"attachment_40314\" style=\"width: 690px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/18e3076e0fda24f6905b06e116426a8b.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-40314\" class=\"wp-image-40314 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/18e3076e0fda24f6905b06e116426a8b-680x332.jpg\" alt=\"\" width=\"680\" height=\"332\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/18e3076e0fda24f6905b06e116426a8b-680x332.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/18e3076e0fda24f6905b06e116426a8b-300x147.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/18e3076e0fda24f6905b06e116426a8b-768x376.jpg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/18e3076e0fda24f6905b06e116426a8b-550x270.jpg 550w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/18e3076e0fda24f6905b06e116426a8b.jpg 814w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><p id=\"caption-attachment-40314\" class=\"wp-caption-text\">\u56fe 4 David MacMillan\u7684\u8bbe\u8ba1\u7406\u5ff5<\/p><\/div>\n<div id=\"attachment_40315\" style=\"width: 690px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/d14b7629af194937004b9828ce140ceb.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-40315\" class=\"wp-image-40315 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/d14b7629af194937004b9828ce140ceb-680x192.jpg\" alt=\"\" width=\"680\" height=\"192\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/d14b7629af194937004b9828ce140ceb-680x192.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/d14b7629af194937004b9828ce140ceb-300x85.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/d14b7629af194937004b9828ce140ceb-768x217.jpg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/d14b7629af194937004b9828ce140ceb-1536x434.jpg 1536w, https:\/\/assets.www.gsbet888.com\/uploads\/2021\/10\/d14b7629af194937004b9828ce140ceb.jpg 1687w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><p id=\"caption-attachment-40315\" class=\"wp-caption-text\">\u56fe 5 \u72c4\u5c14\u65af-\u963f\u5c14\u5fb7\u53cd\u5e94<\/p><\/div>\n<p><a href=\"\/\/www.gsbet888.com\/chemists\/2021\/10\/benjamin-list.html\">Benjamin List <\/a>\u548c<a href=\"\/\/www.gsbet888.com\/chemists\/2014\/11\/post-3283.html\"> David MacMillan<\/a>\u5404\u81ea\u72ec\u7acb\u5730\u53d1\u73b0\u4e86\u4e00\u4e2a\u5168\u65b0\u7684\u50ac\u5316\u6982\u5ff5\u3002\u81ea2000\u5e74\u4ee5\u6765\uff0c\u53ef\u4ee5\u5c06\u8be5\u9886\u57df\u6bd4\u4f5c\u201c\u6dd8\u91d1\u70ed\u201d\uff0c\u4e00\u5927\u6279\u7684\u7814\u7a76\u53ca\u5176\u5e94\u7528\u88ab\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u5bf9\u836f\u7269\u4ee5\u53ca\u7cbe\u7ec6\u5316\u5b66\u54c1\u884c\u4e1a \u4ea7\u751f\u4e86\u5de8\u5927\u7684\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u6709\u673a\u50ac\u5316\u5242\u73b0\u5728\u6b63\u7ed9\u4eba\u7c7b\u5e26\u6765\u6700\u5927\u7684\u597d\u5904\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<ul>\n<li>1 B. List; R. A. Lerner; C. F. Barbas, <i>J. Am. Chem. Soc. <\/i><b>2000,<\/b><i>122<\/i>, 2395,<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja994280y\"> doi:10.1021\/ja994280y.<\/a><\/li>\n<li>2 K. A. Ahrendt; C. J. Borths; D. W. C. MacMillan, <i>J. Am. Chem. Soc. <\/i><b>2000,<\/b> <i>122<\/i>, 4243, doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja000092s\">10.1021\/ja000092s.<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005 \u77f3\u6cb9\u919a \u5bfc\u8bfb \u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u4e8e10\u67086\u65e517\u70b945\u5206\u5728\u745e\u5178\u9996\u90fd\u65af\u5fb7\u54e5\u5c14\u6469\u745e\u5178\u7687\u5bb6\u79d1\u5b66\u9662\u63ed\u6653\uff0c\u8bfa\u8d1d\u5c14\u5956\u59d4\u5458\u4f1a\u5c06\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u6388\u4e88\u5fb7\u56fd\u79d1\u5b66\u5bb6Benjamin List\u548c\u7f8e\u56fd\u79d1\u5b66\u5bb6David W.C. MacMillan\uff0c\u83b7\u5956\u7406\u7531\uff1a\u56e0\u201c\u5728\u4e0d\u5bf9\u79f0\u6709\u673a\u50ac\u5316\u65b9\u9762\u7684\u53d1\u5c55\uff08for the development of asymmetric organocatalysis\uff09\u201d\uff0c\u4ed6\u4eec\u5f00\u53d1\u7684\u5de5\u5177\u5f7b\u5e95\u6539\u53d8\u4e86\u5206\u5b50\u7684\u7ed3\u6784\u3002(\u56fe 1)\u3002 \u83b7\u5956\u7406\u7531 \u4f17\u6240\u5468\u77e5\uff0c\u8bb8\u591a\u9886\u57df\u7814\u7a76\u9886\u57df\u548c\u5de5\u4e1a\u90fd\u4f9d\u8d56\u4e8e\u5316\u5b66\u5bb6\u6784\u5efa\u5206\u5b50\u7684\u80fd\u529b\uff0c\u8fd9\u4e9b\u5206\u5b50\u53ef\u4ee5\u5f62\u6210\u5f39\u6027\u548c\u8010\u7528\u7684\u6750\u6599\uff0c\u5c06\u80fd\u91cf\u50a8\u5b58\u5728\u7535\u6c60\u4e2d\u6216\u6291\u5236\u75be\u75c5\u7684\u8fdb\u5c55\u3002\u7136\u800c\u76f8\u5173\u5206\u5b50\u7684\u6784\u5efa\u5c31\u9700\u8981\u50ac\u5316\u5242\uff0c\u50ac\u5316\u5242\u662f\u63a7\u5236\u548c\u52a0\u901f\u53cd\u5e94\u7684\u7269\u8d28\uff0c\u5176\u5e76\u4e0d\u4f1a\u6210\u4e3a\u6700\u7ec8\u4ea7\u7269\u7684\u4e00\u90e8\u5206\u3002\u4f8b\u5982\uff0c\u6c7d\u8f66\u4e2d\u7684\u50ac\u5316\u5242\u5c06\u5e9f\u6c14\u4e2d\u7684\u6709\u6bd2\u7269\u8d28\u8f6c\u5316\u4e3a\u65e0\u5bb3\u5206\u5b50\u3002\u6211\u4eec\u7684\u8eab\u4f53\u4e5f\u542b\u6709\u6570\u4ee5\u5343\u8ba1\u7684\u9176\u5f62\u5f0f\u7684\u50ac\u5316\u5242\uff0c\u5b83\u4eec\u6784\u5efa\u4e86\u751f\u547d\u6240\u5fc5\u9700\u7684\u5206\u5b50\u3002\u7efc\u4e0a\uff0c\u5316\u5b66\u5206\u5b50\u6784\u5efa\u662f\u4e00\u95e8\u5f88\u56f0\u96be\u5e76\u4e14\u8ff7\u4eba\u7684\u827a\u672f\uff0c\u5438\u5f15\u4e86\u4f17\u591a\u5316\u5b66\u5bb6\u4eec\u7684\u773c\u7403\uff0c\u5176\u8003\u8651\u5982\u4f55\u9ad8\u6548\u5feb\u901f\u4fbf\u6377\u7684\u6784\u5efa\u5206\u5b50\u3002\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u5f97\u4e3b\u5c31\u53d1\u5c55\u4e86\u4e00\u79cd\u7eff\u8272\u9ad8\u6548\u7684\u50ac\u5316\u5242\u53bb\u6784\u5efa\u5316\u5b66\u5206\u5b50\u3002 Benjamin List \u548c David MacMillan \u56e0\u5f00\u53d1\u51fa\u4e00\u79cd\u7cbe\u786e\u7684\u5206\u5b50\u6784\u5efa\u65b0\u5de5\u5177\uff1a \u201c\u6709\u673a\u50ac\u5316\u5242\u201d\u5e76\u5c06\u5176\u7528\u4e8e\u4e0d\u5bf9\u79f0\u50ac\u5316\u9886\u57df\u800c\u83b7\u5f97 2021 \u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u3002\u8fd9\u5bf9\u836f\u7269\u7814\u7a76\u4ee5\u53ca\u7cbe\u7ec6\u5316\u5b66\u54c1\u4ea7\u751f\u4e86\u5de8\u5927\u5f71\u54cd\uff0c\u5e76\u4e14\u5df2\u7ecf\u6781\u5927\u5730\u9020\u798f\u4e8e\u4eba\u7c7b\u3002\u201d \u6df1\u5ea6\u89e3\u6790 \u50ac\u5316\u5242\u662f\u79d1\u5b66\u5bb6\u4eec\u6b66\u5668\u5e93\u4e2d\u6700\u91cd\u8981\u7684\u6b66\u5668\u4e4b\u4e00\u3002\u4f46\u7814\u7a76\u4eba\u5458\u957f\u671f\u4ee5\u6765\u4e00\u76f4\u8ba4\u4e3a\uff0c\u539f\u5219\u4e0a\u53ea\u6709\u4e24\u79cd\u50ac\u5316\u5242\u53ef\u7528\uff1a\u91d1\u5c5e\u548c\u9176\u3002 Benjamin List \u548c David MacMillan \u88ab\u6388\u4e88 2021 \u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\uff0c\u56e0\u4e3a\u4ed6\u4eec\u5728 2000\u5e74\u72ec\u7acb\u5f00\u53d1\u4e86\u7b2c\u4e09\u79cd\u50ac\u5316\u5242\uff0c\u5373\uff1a\u5efa\u7acb\u5728\u6709\u673a\u5c0f\u5206\u5b50\u4e0a\u7684\u4e0d\u5bf9\u79f0\u6709\u673a\u50ac\u5316\u5242\u3002 \u6709\u673a\u50ac\u5316\u5242\u5177\u6709\u4e00\u4e2a\u7a33\u5b9a\u7684\u78b3\u539f\u5b50\u6846\u67b6\uff0c\u66f4\u6d3b\u6cfc\u7684\u5316\u5b66\u57fa\u56e2\u53ef\u4ee5\u9644\u7740\u5728\u78b3\u539f\u5b50\u4e0a\u3002\u8fd9\u4e9b\u57fa\u56e2\u901a\u5e38\u542b\u6709\u6c27\u3001\u6c2e\u3001\u786b\u6216\u78f7\u7b49\u5e38\u89c1\u5143\u7d20\u3002\u8fd9\u610f\u5473\u7740\u8be5\u7c7b\u50ac\u5316\u5242\u65e2\u73af\u4fdd\u4e14\u6210\u672c\u4f4e\u5ec9\u3002\u6709\u673a\u50ac\u5316\u5242\u5e94\u7528\u9886\u57df\u7684\u8fc5\u901f\u6269\u5c55\u4e3b\u8981\u662f\u8be5\u7c7b\u50ac\u5316\u5242\u80fd\u591f\u5728\u4e0d\u5bf9\u79f0\u9886\u57df\u5f88\u597d\u7684\u5e94\u7528\uff0c\u5e76\u4e14\u5bf9\u836f\u7269\u7814\u7a76\u4ee5\u53ca\u7cbe\u7ec6\u5316\u5b66\u54c1\u7684\u4ea7\u751f\u4e86\u5de8\u5927\u5f71\u54cd\u3002\u81ea 2000 \u5e74\u4ee5\u6765\uff0c\u6709\u673a\u50ac\u5316\u4ee5\u60ca\u4eba\u7684\u901f\u5ea6\u53d1\u5c55\u3002Benjamin List \u548c David MacMillan \u4ecd\u7136\u662f\u8be5\u9886\u57df\u7684\u9886\u5bfc\u8005\uff0c\u5e76\u8868\u660e\u6709\u673a\u50ac\u5316\u5242\u53ef\u7528\u4e8e\u9a71\u52a8\u591a\u79cd\u5316\u5b66\u53cd\u5e94\u3002\u5229\u7528\u8fd9\u4e9b\u53cd\u5e94\uff0c\u7814\u7a76\u4eba\u5458\u73b0\u5728\u53ef\u4ee5\u66f4\u6709\u6548\u5730\u6784\u5efa\u4ece\u65b0\u836f\u7269\u5230\u53ef\u4ee5\u5728\u592a\u9633\u80fd\u7535\u6c60\u4e2d\u6355\u83b7\u5149\u5b50\u7684\u591a\u79cd\u7269\u8d28\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u5f0f\uff0c\u6709\u673a\u50ac\u5316\u5242\u6b63\u5728\u4e3a\u4eba\u7c7b\u5e26\u6765\u6700\u5927\u7684\u597d\u5904\u3002 \u9176\u7531\u6570\u767e\u79cd\u6c28\u57fa\u9178\u7ec4\u6210\uff0c\u4f46\u901a\u5e38\u53ea\u6709\u5c11\u6570\u6c28\u57fa\u9178\u53c2\u4e0e\u5316\u5b66\u53cd\u5e94\uff0c\u6765\u6784\u5efa\u6211\u4eec\u8eab\u4f53\u4e2d\u91cd\u8981\u7684\u5206\u5b50\u3002 Benjamin List \u6559\u6388\u5f00\u59cb\u6000\u7591\u662f\u5426\u771f\u7684\u9700\u8981\u6574\u4e2a\u9176\u624d\u80fd\u50ac\u5316\u4e00\u4e2a\u5316\u5b66\u53cd\u5e94\u5462\uff1f\u4e0a\u4e2a\u4e16\u7eaa70\u5e74\u4ee3\uff0c\u4f17\u591a\u5316\u5b66\u5bb6\u4f7f\u7528\u812f\u6c28\u9178\u4f5c\u4e3a\u50ac\u5316\u5242\u8fdb\u884c\u4e86\u5927\u91cf\u7684\u7814\u7a76\u3002\u57fa\u4e8e\u6b64\uff0cBenjamin List \u6559\u6388\u6d4b\u8bd5\u4e86\u812f\u6c28\u91781\u50ac\u5316\u7f9f\u919b\u7f29\u5408\u53cd\u5e94(Aldol Reaction)(\u56fe 2\u548c\u56fe3)\uff0c\u5c31\u662f\u8fd9\u4e2a\u7b80\u5355\u7684\u5c1d\u8bd5\uff0c\u8bc1\u660e\u4e86\u812f\u6c28\u9178\u662f\u4e00\u79cd\u9ad8\u6548\u7684\u50ac\u5316\u5242\uff0c\u63d0\u51fa\u4e86\u300c\u6709\u673a\u50ac\u5316\u5242\u300d\u6982\u5ff5\uff0c\u5df2\u6210\u4e3a\u6709\u673a\u50ac\u5316\u9886\u57df\u7684\u9f3b\u7956\u3002 &nbsp; \u91d1\u5c5e\u50ac\u5316\u5242\u5f88\u5bb9\u6613\u88ab\u6c34\u5206\u4ee5\u53ca\u5176\u4ed6\u56e0\u7d20\u7834\u574f\u3002David MacMillan\u57fa\u4e8e\u8fd9\u6837\u4e00\u4e2a\u51fa\u53d1\u70b9\u601d\u8003\uff0c\u662f\u5426\u6709\u53ef\u80fd\u5f00\u53d1\u4e00\u79cd\u7b80\u5355\u3001\u5ec9\u4ef7\u4e14\u73af\u4fdd\u50ac\u5316\u5242\u53bb\u9a71\u52a8\u4e0d\u5bf9\u79f0\u53cd\u5e94\u3002\u57fa\u4e8e\u6b64\u60f3\u6cd5\uff0cDavid MacMillan\u6559\u6388\u8bbe\u8ba1\u5e76\u5236\u5907\u4e86\u4e00\u79cd\u6709\u673a\u50ac\u5316\u52422\uff0c\u5176\u4e8c\u7ea7\u80fa\u90e8\u4f4d\u4e0e\u5e95\u7269\u53cd\u5e94\u5f62\u6210\u4eb2\u7535\u6027\u9ad8\u7684\u4e9a\u80fa\u4e2d\u95f4\u4f53\uff0c\u6781\u5927\u5730\u50ac\u5316\u72c4\u5c14\u65af-\u963f\u5c14\u5fb7\u53cd\u5e94\u7684\u80fd\u529b(\u56fe 4\u548c\u56fe5)\u3002David MacMillan \u521b\u5236\u51fa\u201c\u6709\u673a\u50ac\u5316\u201d\u4e00\u8bcd\uff0c\u5e76\u63d0\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u6709\u673a\u50ac\u5316\u673a\u7406\u2014\u2014\u4e9a\u80fa\u6d3b\u5316\u3002 Benjamin List \u548c David MacMillan\u5404\u81ea\u72ec\u7acb\u5730\u53d1\u73b0\u4e86\u4e00\u4e2a\u5168\u65b0\u7684\u50ac\u5316\u6982\u5ff5\u3002\u81ea2000\u5e74\u4ee5\u6765\uff0c\u53ef\u4ee5\u5c06\u8be5\u9886\u57df\u6bd4\u4f5c\u201c\u6dd8\u91d1\u70ed\u201d\uff0c\u4e00\u5927\u6279\u7684\u7814\u7a76\u53ca\u5176\u5e94\u7528\u88ab\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u5bf9\u836f\u7269\u4ee5\u53ca\u7cbe\u7ec6\u5316\u5b66\u54c1\u884c\u4e1a \u4ea7\u751f\u4e86\u5de8\u5927\u7684\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u6709\u673a\u50ac\u5316\u5242\u73b0\u5728\u6b63\u7ed9\u4eba\u7c7b\u5e26\u6765\u6700\u5927\u7684\u597d\u5904\u3002 &nbsp; \u53c2\u8003\u6587\u732e 1 B. List; R. A. Lerner; C. F. Barbas, J. Am. Chem. Soc. 2000,122, 2395, doi:10.1021\/ja994280y. 2 K. A. Ahrendt; C. J. Borths; D. W. C. MacMillan, J. Am. Chem. 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