{"id":40730,"date":"2021-12-02T08:00:29","date_gmt":"2021-12-02T00:00:29","guid":{"rendered":"\/\/www.gsbet888.com\/?p=40730"},"modified":"2021-11-29T17:16:42","modified_gmt":"2021-11-29T09:16:42","slug":"%e5%8e%a6%e9%97%a8%e5%a4%a7%e5%ad%a6%e5%be%90%e6%b5%b7%e8%b6%85%e8%af%be%e9%a2%98%e7%bb%84nat-commun-%ef%bc%9a-%e8%bf%9e%e7%bb%ad%e6%b5%81%e5%8a%a8%e6%9d%a1%e4%bb%b6%e4%b8%8b%e7%9a%84%e7%94%b5","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2021\/12\/%e5%8e%a6%e9%97%a8%e5%a4%a7%e5%ad%a6%e5%be%90%e6%b5%b7%e8%b6%85%e8%af%be%e9%a2%98%e7%bb%84nat-commun-%ef%bc%9a-%e8%bf%9e%e7%bb%ad%e6%b5%81%e5%8a%a8%e6%9d%a1%e4%bb%b6%e4%b8%8b%e7%9a%84%e7%94%b5.html","title":{"rendered":"\u53a6\u95e8\u5927\u5b66\u5f90\u6d77\u8d85\u8bfe\u9898\u7ec4Nat. Commun.\uff1a \u8fde\u7eed\u6d41\u52a8\u6761\u4ef6\u4e0b\u7684\u7535\u5316\u5b66\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u65b9\u6cd5\u5b66"},"content":{"rendered":"

\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749<\/strong><\/p>\n

\u5bfc\u8bfb<\/h4>\n

\u6709\u673a\u78f7\u5316\u5408\u7269\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5316\u5b66\u3001\u6750\u6599\u79d1\u5b66\u4ee5\u53ca\u751f\u7269\u5b66\u9886\u57df\u7684\u76f8\u5173\u7814\u7a76\u3002\u56e0\u6b64\uff0c\u8bbe\u8ba1\u66f4\u4e3a\u9ad8\u6548\u7684\u6784\u5efaC-P\u952e\u7684\u5168\u65b0\u7b56\u7565\uff0c\u5728\u6709\u673a\u5408\u6210\u5316\u5b66\u7814\u7a76\u4e2d\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u5176\u4e2d\uff0c\u524d\u671f\u5df2\u7ecf\u62a5\u9053\u7684\u4e00\u7cfb\u5217\u5728\u975e\u7535\u5316\u5b66\u6216\u7535\u5316\u5b66\u6761\u4ef6\u4e0b\u8fdb\u884c\u7684C-H\u81a6\u9178\u916f\u5316\u53cd\u5e94 (C-H\u00a0phosphorylation)\u65b9\u6cd5\u5b66\u7684\u76f8\u5173\u7814\u7a76\u4e2d\uff0c\u901a\u5e38\u9700\u8981\u5f15\u5165\u76f8\u5e94\u7684\u5bfc\u5411\u57fa\u56e2\u3001\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u5242\u6216\u5316\u5b66\u6c27\u5316\u5242\uff0c\u540c\u65f6\uff0c\u5e95\u7269\u5e94\u7528\u8303\u56f4\u8f83\u4e3a\u6709\u9650\u3002\u4e3a\u89e3\u51b3\u4e0a\u8ff0\u95ee\u9898\uff0c\u8fd1\u65e5\uff0c\u53a6\u95e8\u5927\u5b66\u7684\u5f90\u6d77\u8d85\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5728\u65e0\u50ac\u5316\u5242\u4e0e\u65e0\u5916\u90e8\u6c27\u5316\u5242\u4ee5\u53ca\u8fde\u7eed\u6d41\u52a8\u7684\u6761\u4ef6\u4e0b\u8fdb\u884c\u7684\u7535\u5316\u5b66\u82b3\u9999C-H\u81a6C-H\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b9e\u73b0\u4e00\u7cfb\u5217\u82b3\u57fa\u81a6C-H\u7c7b\u5316\u5408\u7269\u7684\u6784\u5efa\u3002\u5728\u8fd9\u4e00\u5168\u65b0\u7684\u7535\u5316\u5b66\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u7b56\u7565\u4e2d\uff0c\u901a\u8fc7\u82b3\u57fa\u5316\u5408\u7269\u4e0e\u9633\u6781\u4ea7\u751f\u7684P-\u81ea\u7531\u57fa\u6b63\u79bb\u5b50\u4e4b\u95f4\u7684\u53cd\u5e94\u8fc7\u7a0b\uff0c\u8fdb\u800c\u5f62\u6210\u76f8\u5e94\u7684C-P\u952e\u3002\u540c\u65f6\uff0c\u901a\u8fc7\u5177\u6709\u9ad8\u5ea6\u53cd\u5e94\u6d3b\u6027\u7684P-\u81ea\u7531\u57fa\u6b63\u79bb\u5b50\u4e0e\u6e29\u548c\u7684\u6709\u673a\u7535\u5408\u6210\u53cd\u5e94\u6761\u4ef6\u7684\u7ed3\u5408\uff0c\u8fdb\u800c\u4f7f\u4e00\u7cfb\u5217\u5177\u6709\u4e0d\u540c\u7535\u5b50\u7279\u6027\u7684\u82b3\u57fa\u5316\u5408\u7269\u80fd\u591f\u6709\u6548\u5730\u53c2\u4e0e\u4e0a\u8ff0\u7684\u81a6\u9178\u916f\u5316\u8fc7\u7a0b\u3002\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u8fd9\u4e00\u5168\u65b0\u7684\u81a6\u9178\u916f\u5316\u7b56\u7565\u8fdb\u4e00\u6b65\u5e94\u7528\u4e8e\u5404\u7c7b\u590d\u6742\u5929\u7136\u4ea7\u7269\u4e0e\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u7684\u9009\u62e9\u6027\u540e\u671f\u5b98\u80fd\u56e2\u5316\u8fc7\u7a0b\u7684\u76f8\u5173\u7814\u7a76\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u7535\u5316\u5b66\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u7b56\u7565\u540c\u6837\u80fd\u591f\u987a\u5229\u5b8c\u6210\u76f8\u5e94\u7684\u514b\u7ea7\u89c4\u6a21\u53cd\u5e94\uff0c\u8fdb\u800c\u8868\u660e\u8fd9\u4e00\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u3002<\/p>\n

Electrochemical C-H phosphorylation of arenes in continuous flow suitable for late-stage functionalization
\nH. Long, C. Huang, Y. Zheng, Z. Li, L. Jie, J. Song, S. Zhu, H. C. Xu, Nat. Commun.<\/em> 2021<\/strong>, ASAP doi: 10.1038\/s41467-021-26960-y<\/u><\/a>.<\/u><\/p><\/blockquote>\n

\"\"<\/a><\/p>\n

\u6b63\u6587<\/h4>\n

\u82b3\u57fa\u78f7\u5316\u5408\u7269\u76ee\u524d\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u533b\u836f\u5316\u5b66\u3001\u6750\u6599\u79d1\u5b66\u4ee5\u53ca\u50ac\u5316\u914d\u4f53\u4e0eLewis\u9178\u50ac\u5316\u9886\u57df\u7684\u76f8\u5173\u7814\u7a76\u3002\u4e0e\u4f20\u7edf\u7684Hirao\u53cd\u5e94\u65b9\u6cd5\u5b66[1]<\/sup>\u76f8\u6bd4\uff0cC-H\u81a6\u9178\u916f\u5316\u7b56\u7565\u66f4\u52a0\u5177\u6709\u5438\u5f15\u529b\uff0c\u5e76\u4e14\u80fd\u591f\u6709\u6548\u5730\u907f\u514d\u76f8\u5173\u5e95\u7269\u7684\u9884\u5b98\u80fd\u56e2\u5316\u6b65\u9aa4\u3002\u76ee\u524d\uff0c\u5bf9\u4e8e\u975e\u7535\u5316\u5b66\u6761\u4ef6\u4e0b\u7684\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u65b9\u6cd5\u5b66\u7684\u76f8\u5173\u7814\u7a76\u00a0(Fig. 1a-b)\uff0c\u5df2\u7ecf\u6709\u8bf8\u591a\u7684\u6587\u732e\u62a5\u9053[2]<\/sup>-[4]<\/sup>\u3002\u7136\u800c\uff0c\u4e0a\u8ff0\u7684\u5408\u6210\u8f6c\u5316\u8fc7\u7a0b\u4e2d\uff0c\u901a\u5e38\u9700\u8981\u52a0\u5165\u8fc7\u91cf\u7684\u82b3\u57fa\u5e95\u7269\uff0c\u800c\u4e14\u5e95\u7269\u5e94\u7528\u8303\u56f4\u5341\u5206\u6709\u9650\u3002<\/p>\n

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\u63a5\u4e0b\u6765\uff0c\u53d7\u5230\u901a\u8fc7\u80fa\u57fa\u81ea\u7531\u57fa (aminyl radical)\u8d28\u5b50\u5316\u5f62\u6210\u7684\u80fa\u6b63\u79bb\u5b50\u81ea\u7531\u57fa (aminium radical)\u80fd\u591f\u663e\u8457\u63d0\u9ad8\u03c0-\u4f53\u7cfb\u53cd\u5e94\u6d3b\u6027\u7684\u76f8\u5173\u7814\u7a76\u62a5\u9053[<\/sup>12<\/sup>]<\/sup>-[13]<\/sup>\u7684\u542f\u53d1\uff0c\u4f5c\u8005\u8bbe\u60f3\uff0c\u4e0eP-\u81ea\u7531\u57fa\u76f8\u6bd4\uff0cP-\u81ea\u7531\u57fa\u6b63\u79bb\u5b50\u5177\u6709\u66f4\u9ad8\u7684\u53cd\u5e94\u6d3b\u6027\uff0c\u8fdb\u800c\u80fd\u591f\u4e0e\u5404\u7c7b\u7f3a\u7535\u5b50\u82b3\u57fa\u5e95\u7269\u8fdb\u884c\u6709\u6548\u7684\u53cd\u5e94 (Fig. 1c)\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u8bbe\u60f3\uff0c\u91c7\u7528\u8fde\u7eed\u6d41\u52a8\u7684\u7535\u5316\u5b66\u53cd\u5e94\u5668\uff0c\u53ef\u80fd\u66f4\u52a0\u6709\u5229\u4e8eP-\u81ea\u7531\u57fa\u6b63\u79bb\u5b50\u7684\u5f62\u6210\uff0c\u5e76\u901a\u8fc7\u82b3\u57fa\u5e95\u7269\u7684\u6355\u83b7\uff0c\u5f62\u6210\u76f8\u5e94\u7684\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u4ea7\u7269\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7684\u7814\u7a76\u8bbe\u60f3\uff0c\u53a6\u95e8\u5927\u5b66\u7684\u5f90\u6d77\u8d85\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5728\u8fde\u7eed\u6d41\u52a8\u6761\u4ef6\u4e0e\u65e0\u50ac\u5316\u5242\u4ee5\u53ca\u65e0\u5916\u90e8\u6c27\u5316\u5242\u5b58\u5728\u6761\u4ef6\u4e0b\u8fdb\u884c\u7684\u7535\u5316\u5b66\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u7684\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u987a\u5229\u5b8c\u6210\u4e00\u7cfb\u5217\u82b3\u57fa\u81a6\u9178\u916f\u5206\u5b50\u7684\u6784\u5efa (Fig. 1d)\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u75281<\/strong>\u4e0eP(OEt)3<\/sub>\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u81a6\u9178\u916f\u5316\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u5728\u77f3\u58a8\u4f5c\u4e3a\u9633\u6781\uff0cPt\u4f5c\u4e3a\u9634\u6781\u7684\u65e0\u9694\u819c\u8fde\u7eed\u6d41\u52a8\u7535\u89e3\u69fd\u4e2d\uff0c\u91c7\u7528HBF4<\/sub>\u4f5c\u4e3a\u9178\u6027\u6dfb\u52a0\u5242\uff0cH2<\/sub>O\u4f5c\u4e3a\u6dfb\u52a0\u5242\uff0cMeCN\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u6d41\u901f\u4e3a0.2 ml\/min-1<\/sup>\uff0c\u63a7\u5236\u7535\u6d41\u4e3a45-55 mA\uff0c\u6700\u7ec8\u83b7\u5f9770%\u6536\u7387\u7684\u81a6\u9178\u916f\u5316\u4ea7\u72692<\/strong>\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u9996\u5148\u5bf9\u4e00\u7cfb\u5217\u82b3\u57fa\u5e95\u7269\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u8003\u5bdf (Fig. 2)\u3002\u7814\u7a76\u8868\u660e\uff0c\u4e00\u7cfb\u5217\u5e26\u6709\u4f9b\u7535\u5b50\u4e0e\u5438\u7535\u5b50\u57fa\u56e2\u53d6\u4ee3\u7684\u82b3\u57fa\u5e95\u7269\u5747\u80fd\u8f83\u597d\u5730\u4e0e\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u517c\u5bb9\uff0c\u5e76\u83b7\u5f97\u76f8\u5e94\u7684\u81a6\u9178\u916f\u5316\u4ea7\u72693<\/strong>–28<\/strong>\u00a0<\/strong>(26-94%\u00a0\u6536\u7387)\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cC-P\u952e\u5f62\u6210\u8fc7\u7a0b\u7684\u533a\u57df\u9009\u62e9\u6027\u4e0eFriedel-Crafts\u53cd\u5e94\u7c7b\u4f3c\uff0c\u5373\u82b3\u57fa\u5e95\u7269\u4e2d\u65e0\u9ad8\u5ea6\u7acb\u4f53\u4f4d\u963b\u57fa\u56e2\u5b58\u5728\u65f6\uff0c\u53cd\u5e94\u4f18\u5148\u5728\u4f9b\u7535\u5b50\u57fa\u56e2\u7684\u90bb\u4f4d\u6216\u5bf9\u4f4d\u8fdb\u884c\u3002\u4e4b\u540e\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c2-\u53d6\u4ee3\u567b\u5429\u5e95\u7269\uff0c\u540c\u6837\u80fd\u591f\u6709\u6548\u5730\u5b8c\u6210\u4e0a\u8ff0\u7684\u81a6\u9178\u916f\u5316\u8fc7\u7a0b\uff0c\u5e76\u83b7\u5f97\u76f8\u5e94\u76844-\u81a6\u9178\u916f\u4ea7\u726929<\/strong>\u4e0e30<\/strong>\u3002\u63a5\u4e0b\u6765\uff0c\u8be5\u5c0f\u7ec4\u8fdb\u4e00\u6b65\u5bf9\u4e00\u7cfb\u5217\u4e9a\u78f7\u9178\u916f\u7684\u5e95\u7269\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002\u4f5c\u8005\u53d1\u73b0\uff0c\u4e00\u7cfb\u5217\u5177\u6709\u4e0d\u540c\u4e00\u7ea7\u70f7\u57fa\u94fe\u7684\u4e9a\u78f7\u9178\u4e09\u70f7\u57fa\u916f\u5e95\u7269\uff0c\u5747\u80fd\u591f\u987a\u5229\u5730\u53c2\u4e0e\u4e0a\u8ff0\u7684\u81a6\u9178\u916f\u5316\u8fc7\u7a0b\uff0c\u5e76\u83b7\u5f97\u76f8\u5e94\u7684\u76ee\u6807\u4ea7\u726931<\/strong>–36<\/strong>\u00a0<\/strong>(45-77%\u00a0\u6536\u7387)\u3002\u6b64\u5916\uff0c\u7814\u7a76\u53d1\u73b0\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u81a6\u9178\u916f\u5316\u7b56\u7565\u540c\u6837\u80fd\u591f\u826f\u597d\u5730\u5e94\u7528\u4e8e\u5404\u7c7b\u590d\u6742\u5929\u7136\u4ea7\u7269\u4ee5\u53ca\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269 (37<\/strong>–46<\/strong>)\u7684\u540e\u671f\u5b98\u80fd\u56e2\u5316\u8fc7\u7a0b\u3002\u540c\u65f6\uff0c\u8be5\u5c0f\u7ec4\u8fdb\u4e00\u6b65\u89c2\u5bdf\u5230\uff0c\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u5bf9\u4e8e\u4e00\u7cfb\u5217\u5177\u6709\u591a\u91cd\u82b3\u73af\u5b58\u5728\u7684\u82b3\u57fa\u5316\u5408\u7269\uff0c\u5176\u81a6\u9178\u916f\u5316\u8fc7\u7a0b\u5219\u4f18\u5148\u9009\u62e9\u5728\u6700\u4e3a\u5bcc\u7535\u5b50\u7684\u82b3\u73af\u4e2d\u8fdb\u884c (38<\/strong>\u300140<\/strong>\u300141<\/strong>\u4e0e46<\/strong>)\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e4b\u540e\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u5bf9\u4e0a\u8ff0\u81a6\u9178\u916f\u5316\u7b56\u7565\u7684\u5408\u6210\u5b9e\u7528\u6027\u8fdb\u884c\u7814\u7a76 (Fig. 3)\u3002\u9996\u5148\uff0c\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c\u5c06\u5747\u4e09\u7532\u82ef\u5e95\u7269\u3001P(OEt)3<\/sub>\u7684MeCN\u6eb6\u6db2\u4ee5\u53caHBF4<\/sub>\u6dfb\u52a0\u5242\u3001H2<\/sub>O-MeCN\u6df7\u5408\u6eb6\u5242\u5206\u522b\u901a\u8fc7\u91c7\u7528\u4e24\u91cd\u5e73\u884c\u7684\u8fde\u7eed\u6d41\u52a8\u7535\u89e3\u69fd\u6784\u6210\u7684\u53cd\u5e94\u5668\u8fdb\u884c\u5145\u5206\u6df7\u5408\u4e4b\u540e\uff0c\u80fd\u591f\u987a\u5229\u5b8c\u6210\u514b\u7ea7\u89c4\u6a21 (214 mmol\u7684)\u81a6\u9178\u916f\u5316\u53cd\u5e94\uff0c\u5e76\u4ee5\u826f\u597d\u7684\u53cd\u5e94\u6536\u7387 (83%)\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u4e09\u7532\u82ef\u57fa\u81a6\u9178\u916f\u4ea7\u7269 27<\/strong>\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u89c2\u5bdf\u5230\uff0c\u901a\u8fc7\u4e0a\u8ff0\u81a6\u9178\u916f\u5316\u7b56\u7565\u83b7\u5f97\u7684\u7532\u57fa\u81a6\u9178\u916f\u4ea7\u726927<\/strong>\u80fd\u591f\u6709\u6548\u5730\u8f6c\u5316\u4e3a\u5176\u5b83\u4e0d\u540c\u7c7b\u578b\u7684\u6709\u673a\u78f7\u780c\u575747<\/strong>-54<\/strong>\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u63a5\u4e0b\u6765\uff0c\u4e3a\u63d0\u51fa\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406\uff0c\u4f5c\u8005\u8fdb\u884c\u4e00\u7cfb\u5217\u76f8\u5173\u7684\u5b9e\u9a8c\u7814\u7a76 (Fig. 4)\u3002\u9996\u5148\uff0c\u4f5c\u8005\u901a\u8fc7P(OEt)3<\/sub>\u3001\u82b3\u57fa\u5e95\u72691<\/strong>\u4ee5\u53caHPO(OEt)2<\/sub>\u7684CV\u5b9e\u9a8c\u8868\u660e\uff0c\u5728\u4e0a\u8ff0\u7684\u4e09\u79cd\u6709\u673a\u78f7\u5206\u5b50\u4e2d\uff0cP(OEt)3<\/sub>\u00a0<\/sub>(Ep\/2<\/sub>\u00a0= 1.50 V vs SCE)\u80fd\u591f\u6700\u4e3a\u5bb9\u6613\u5730\u53c2\u4e0e\u76f8\u5e94\u7684\u6c27\u5316\u8fc7\u7a0b (Fig. 4a)\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u901a\u8fc7\u5bf9\u82b3\u57fa\u5e95\u72691<\/strong>\u4e0eP(OEt)3<\/sub>\u7684\u53cd\u5e94\u6df7\u5408\u7269\uff0c\u5728\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u4ee5\u53ca\u65e0\u6c34\u5b58\u5728\u65f6\u7684\u76f8\u517331<\/sup>P-NMR\u8c31\u56fe\u5206\u6790 (Fig. 4b)\u8868\u660e\uff0cP(OEt)3<\/sub>\u5728\u65e0\u6c34\u5b58\u5728\u7684\u6761\u4ef6\u4e0b\uff0c\u80fd\u591f\u5206\u89e3\u4e3a\u591a\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u6709\u673a\u542b\u78f7\u4e2d\u95f4\u4f53\u3002\u76f8\u53cd\u5730\uff0c\u5728\u6807\u51c6\u6761\u4ef6\u4e0b\uff0c\u901a\u8fc731<\/sup>P-NMR\u5206\u6790\uff0c\u5219\u80fd\u591f\u6210\u529f\u6307\u8ba4\u51fa\u4e09\u79cd\u4e3b\u8981\u7684\u6709\u673a\u78f7\u4e2d\u95f4\u4f53\uff0c\u5373\u5316\u5408\u72692<\/strong>\u3001HPO(OEt)2<\/sub>\u4e0eOP(OEt)3<\/sub>\u3002\u540c\u65f6\uff0c\u7531\u4e8e\u4e9a\u78f7\u9178\u4e09\u70f7\u57fa\u916f\u5728\u9178\u7684\u4fc3\u8fdb\u4e0b\uff0c\u80fd\u591f\u8fc5\u901f\u6c34\u89e3\uff0c\u5f62\u6210\u76f8\u5e94\u7684H-\u78f7\u9178\u916f (H-phosphonate)\uff0c\u56e0\u6b64\uff0c\u4f5c\u8005\u89c2\u5bdf\u5230\uff0c\u5728P(OEt)3<\/sub>\u4e0eHPO(OEt)2<\/sub>\u5b58\u5728\u4ee5\u53ca\u672a\u52a0\u5165\u6c34\u7684\u6761\u4ef6 (\u53cd\u5e94\u6761\u4ef6II\u4e0e\u00a0III)\u4e0b\uff0c\u91c7\u7528\u82b3\u57fa\u5e95\u72691<\/strong>\u8fdb\u884c\u7684\u81a6\u9178\u916f\u5316\u8fc7\u7a0b\u4e2d\uff0c\u57282\u00a0eq. HPO(OEt)2<\/sub>\u5b58\u5728\u4e0b\uff0c\u80fd\u591f\u83b7\u5f9758%\u7684\u53cd\u5e94\u6536\u7387\uff1b\u800c\u57280.2\u00a0eq. HPO(OEt)2<\/sub>\u5b58\u5728\u4e0b\uff0c\u5219\u80fd\u591f\u83b7\u5f97\u66f4\u52a0\u4f18\u826f\u7684\u53cd\u5e94\u6536\u7387 (78%, Fig. 4b)\u3002\u540c\u65f6\uff0c\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c\u5728\u6761\u4ef6II\u4e0e\u00a0III\u4e2d\uff0c\u53cd\u5e94\u6df7\u5408\u7269\u768431<\/sup>P-NMR\u8c31\u56fe\u4e0e\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u4e0b\u768431<\/sup>P-NMR\u8c31\u56fe\u5341\u5206\u7c7b\u4f3c\u3002<\/p>\n

\u4e4b\u540e\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u82b3\u57fa\u5e95\u72691<\/strong>\u5728P(OEt)3<\/sub>\u4e0eHPO(OnBu)2<\/sub>\u5b58\u5728\u4e0b\u8fdb\u884c\u7684\u7535\u89e3\u8fc7\u7a0b\u4e2d\uff0c\u5219\u83b7\u5f9751%\u6536\u7387\u7684\u81a6\u9178\u916f\u5316\u4ea7\u72692<\/strong>\u4ee5\u53ca\u75d5\u91cf\u7684\u4ea7\u726955<\/strong>\u00a0<\/strong>(Fig. 4c)\uff0c\u8fdb\u800c\u8868\u660e\u81a6\u9178\u916f\u4ea7\u7269\u4e2d\u7684PO(OR)2<\/sub>\u57fa\u56e2\u6e90\u81ea\u4e8eP(OR)3<\/sub>\u800c\u975eHPO(OR)2<\/sub>\u3002\u540c\u65f6\uff0c\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c\u53cd\u5e94\u6df7\u5408\u7269\u4e2d\u52a0\u5165H2<\/sub>18<\/sup>O\u65f6\uff0c\u5728\u81a6\u9178\u916f\u5316\u4ea7\u72692<\/strong>\u4e2d\u5e76\u672a\u68c0\u6d4b\u51fa18<\/sup>O \u7684\u5b58\u5728 (Fig. 4d)\u3002\u7efc\u4e0a\u5b9e\u9a8c\u89c2\u5bdf\u8868\u660e\uff0cHPO(OR)2<\/sub>\u7684\u5b58\u5728\u5bf9\u4e8eC-H\u81a6\u9178\u916f\u5316\u53cd\u5e94\u7684\u987a\u5229\u8fdb\u884c\u5c24\u4e3a\u5173\u952e\u3002\u7136\u800c\uff0c\u53cd\u5e94\u8fc7\u7a0b\u4e2dHPO(OR)2<\/sub>\u7684\u5177\u4f53\u4f5c\u7528\u5219\u4ecd\u6709\u5f85\u6df1\u5165\u7814\u7a76\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u901a\u8fc7\u82ef\u4e0e\u82ef-d<\/em>6<\/sub>\u4e4b\u95f4\u5206\u5b50\u95f4\u7ade\u4e89\u53cd\u5e94\u5b9e\u9a8c\uff0c\u89c2\u5bdf\u5230KIE\u4e3a1.0\uff0c\u8fdb\u800c\u8868\u660e\uff0c\u7535\u89e3\u53cd\u5e94\u7684\u51b3\u901f\u6b65\u9aa4\u4e2d\u5e76\u672a\u6d89\u53caC(aryl)-H\u952e\u7684\u65ad\u88c2 (Fig.\u00a04e)\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u57fa\u4e8e\u4e0a\u8ff0\u7814\u7a76\uff0c\u4f5c\u8005\u63d0\u51fa\u4e00\u79cd\u53ef\u80fd\u7684\u53cd\u5e94\u673a\u7406 (Fig.\u00a04f)\u3002\u9996\u5148\uff0c\u901a\u8fc7\u4e9a\u78f7\u9178\u4e09\u70f7\u57fa\u916f56<\/strong>\u7684\u9633\u6781\u6c27\u5316\u8fc7\u7a0b\uff0c\u5f62\u6210\u76f8\u5e94\u7684P-\u81ea\u7531\u57fa\u6b63\u79bb\u5b5057<\/strong>\uff0c\u518d\u901a\u8fc757<\/strong>\u4e0e\u82b3\u57fa\u5e95\u726958<\/strong>\u4f5c\u7528\uff0c\u5f62\u6210\u76f8\u5e94\u7684\u8fdc\u7a0b\u81ea\u7531\u57fa\u6b63\u79bb\u5b5059<\/strong>\u3002\u4e4b\u540e\uff0c59<\/strong>\u7ecf\u5386\u8fdb\u4e00\u6b65\u7684\u9633\u6781\u6c27\u5316\u4ee5\u53ca\u540e\u7eed\u7684\u53bb\u8d28\u5b50\u5316\u8fc7\u7a0b\uff0c\u5f62\u6210phosphonium\u4e2d\u95f4\u4f5360<\/strong>\u3002\u63a5\u4e0b\u6765\uff0c\u901a\u8fc7P(OR)3<\/sub>\u6c34\u89e3\u6216\u53cd\u5e94\u540e\u5904\u7406\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684\u6c34\u6216\u9187\u5206\u5b50\u5bf9\u4e8e\u4e2d\u95f4\u4f5360<\/strong>\u7684\u4eb2\u6838\u8fdb\u653b\u8fc7\u7a0b\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u81a6\u9178\u916f\u5316\u4ea7\u726961<\/strong>\u3002\u540c\u65f6\uff0c\u5728\u9178\u6027\u6761\u4ef6\u4e0b\uff0c\u53cd\u5e94\u6df7\u5408\u7269\u4e2d\u5927\u91cf\u5b58\u5728\u7684\u8d28\u5b50\u80fd\u591f\u5728Pt\u9634\u6781\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u8fd8\u539f\u6790\u6c22\u8fc7\u7a0b\uff0c\u5f62\u6210H2<\/sub>\u3002\u6b64\u5916\uff0c\u9178\u6027\u6dfb\u52a0\u5242HBF4<\/sub>\u9664\u80fd\u591f\u4fc3\u8fdbP(OR)3<\/sub>\u7684\u6c34\u89e3\u4e4b\u5916\uff0c\u540c\u6837\u80fd\u591f\u4f5c\u4e3a\u652f\u6301\u7535\u89e3\u8d28\u4ee5\u53ca\u6790\u6c22\u8fc7\u7a0b\u4e2d\u7684\u8d28\u5b50\u6e90\uff0c\u8fdb\u800c\u6709\u6548\u907f\u514d\u7f3a\u7535\u5b50\u7684\u4e2d\u95f4\u4f5360<\/strong>\u4ee5\u53ca\u76ee\u6807\u5206\u5b5061<\/strong>\u8fdb\u4e00\u6b65\u53c2\u4e0e\u540e\u7eed\u7684\u9634\u6781\u8fd8\u539f\u8fc7\u7a0b\u3002\u5e76\u4e14\uff0c\u901a\u8fc7P(OR)3<\/sub>\u6c34\u89e3\u539f\u4f4d\u5f62\u6210\u7684HPO(OR)2<\/sub>\u4e2d\u95f4\u4f53\uff0c\u540c\u6837\u53ef\u80fd\u4e0e\u81ea\u7531\u57fa\u6b63\u79bb\u5b5057<\/strong>\u901a\u8fc7\u540e\u7eed\u7684\u53ef\u9006\u53cd\u5e94\u6b65\u9aa4\uff0c\u5f62\u6210\u76f8\u5e94\u7684\u52a0\u5408\u726962<\/strong>\uff0c\u8fdb\u800c\u6709\u6548\u5730\u51cf\u5f3157<\/strong>\u7684\u8fdb\u4e00\u6b65\u5206\u89e3\u3002\u56e0\u6b64\uff0c\u81ea\u7531\u57fa\u6b63\u79bb\u5b5057<\/strong>\u80fd\u591f\u987a\u5229\u5730\u53c2\u4e0e\u540e\u7eed\u7684\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u8fc7\u7a0b\u3002<\/p>\n

\u603b\u7ed3<\/h4>\n

\u53a6\u95e8\u5927\u5b66\u7684\u5f90\u6d77\u8d85\u6559\u6388\u8bfe\u9898\u7ec4\u5728\u8fde\u7eed\u6d41\u52a8\u7684\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u3002\u53cd\u5e94\u8fc7\u7a0b\u4e2d\uff0c\u65e0\u9700\u52a0\u5165\u76f8\u5e94\u7684\u5206\u5b50\u50ac\u5316\u5242\u4ee5\u53ca\u4f20\u7edf\u7684\u5316\u5b66\u6c27\u5316\u5242\u3002\u540c\u65f6\uff0c\u8fd9\u4e00\u5168\u65b0\u7684C-H\u81a6\u9178\u916f\u5316\u7b56\u7565\u5177\u6709\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\u3001\u5e95\u7269\u5e94\u7528\u8303\u56f4\u5e7f\u6cdb\u3001\u9ad8\u5ea6\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u9ad8\u7b49\u4f18\u52bf\u3002<\/p>\n

\u53c2\u8003\u6587\u732e<\/b><\/strong><\/h4>\n[1] C. S.\u00a0Demmer, N. Krogsgaard-Larsen, L. Bunch, Chem. Rev. <\/em>2011<\/strong>, 111<\/em>, 7981.\u00a0doi:\u00a010.1021\/cr2002646<\/u><\/a>.<\/u><\/p>\n[2] (a)\u00a0C. G. Feng, M. Ye, K. J. Xiao, S. Li, J. Q. Yu, J. Am. Chem. Soc.<\/em>\u00a02013<\/strong>, 135<\/em>, 9322.\u00a0doi:\u00a010.1021\/ja404526x<\/u><\/a>.<\/u><\/p>\n

(b) C.\u00a0Li, T.\u00a0Yano, N. Ishida, M. Murakami, Angew. Chem. Int. Ed.<\/em>\u00a02013<\/strong>, 52<\/em>,\u00a09801.\u00a0doi:\u00a010.1002\/ange.201305202<\/u><\/a>.<\/u><\/p>\n[3] L.\u00a0Niu, J.\u00a0Liu, H.\u00a0Yi, S.\u00a0Wang, X.\u00a0Liang, A.\u00a0Singh, C.\u00a0Chiang, A.\u00a0Lei, ACS Catal.<\/em>\u00a02017<\/strong>, 7<\/em>, 7412.\u00a0doi:\u00a010.1021\/acscatal.7b02418<\/u><\/a>.<\/u><\/p>\n[4] O. Berger, J. L.\u00a0Montchamp, J. Org. Chem.<\/em>\u00a02019<\/strong>, 84<\/em>, 9239.\u00a0doi:\u00a010.1021\/acs.joc.9b01239<\/u><\/a>.<\/u><\/p>\n[5] S.\u00a0Wang, Q. Xue, Z. Guan, Y. Ye, A. Lei,\u00a0ACS Catal.<\/em>\u00a02021<\/strong>, 11<\/em>, 4295.\u00a0doi:\u00a010.1021\/acscatal.1c00549<\/u><\/a>.<\/u><\/p>\n[6] Z.\u00a0Wu,\u00a0F.\u00a0Su,\u00a0W.\u00a0Lin,\u00a0J.\u00a0Song, T.\u00a0Wen, H.\u00a0Zhang,\u00a0H.\u00a0Xu, Angew. Chem. Int.<\/em>\u00a0<\/em>Ed.<\/em>\u00a02019<\/strong>, 58<\/em>, 16770.\u00a0doi:\u00a010.1002\/anie.201909951<\/u><\/a>.<\/u><\/p>\n[7] S. O. Strekalova,\u00a0V. V. Grinenko, T. V. Gryaznova, A. I. Kononov, E. L. Dolengovski, Y. H.\u00a0Budnikova, Phosphorus Sulfur Silicon<\/i><\/em>\u00a0<\/i><\/em>Relat. Elem.<\/i><\/em>\u00a0<\/i><\/b><\/em><\/strong>2019<\/b><\/strong>, 194<\/i><\/em>, 506.\u00a0doi:\u00a010.1080\/10426507.2018.1540488<\/u><\/a>. <\/u><\/p>\n[8] M. N. Khrizanforov, S. O. Strekalova, K.V. Kholin, V. V. Khrizanforova, M. K. Kadirov, T. V. Gryaznova, Y. H.\u00a0Budnikova, Catal. Today<\/i><\/em>\u00a02017<\/b><\/strong>, 279<\/i><\/em>, 133. doi:\u00a010.1016\/j.cattod.2016.06.001<\/u><\/a>.<\/u><\/p>\n[9] E. O. Yurko, T. V. Gryaznova, Y. H. Budnikova, Phosphorus Sulfur Silicon Relat. Elem.<\/i><\/em>\u00a0<\/i><\/b><\/em><\/strong>2019<\/b><\/strong>, 194<\/i><\/em>,\u00a0343.\u00a0doi:\u00a010.1080\/10426507.2018.1541897<\/u><\/a>. <\/u><\/p>\n[10] M. N. 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Knowles, ACS Catal.<\/i><\/em>\u00a02020<\/b><\/strong>,10,<\/i><\/em> 11712. doi:\u00a010.1021\/acscatal.0c03567<\/u><\/a>.<\/u><\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb \u6709\u673a\u78f7\u5316\u5408\u7269\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5316\u5b66\u3001\u6750\u6599\u79d1\u5b66\u4ee5\u53ca\u751f\u7269\u5b66\u9886\u57df\u7684\u76f8\u5173\u7814\u7a76\u3002\u56e0\u6b64\uff0c\u8bbe\u8ba1\u66f4\u4e3a\u9ad8\u6548\u7684\u6784\u5efaC-P\u952e\u7684\u5168\u65b0\u7b56\u7565\uff0c\u5728\u6709\u673a\u5408\u6210\u5316\u5b66\u7814\u7a76\u4e2d\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u5176\u4e2d\uff0c\u524d\u671f\u5df2\u7ecf\u62a5\u9053\u7684\u4e00\u7cfb\u5217\u5728\u975e\u7535\u5316\u5b66\u6216\u7535\u5316\u5b66\u6761\u4ef6\u4e0b\u8fdb\u884c\u7684C-H\u81a6\u9178\u916f\u5316\u53cd\u5e94 (C-H\u00a0phosphorylation)\u65b9\u6cd5\u5b66\u7684\u76f8\u5173\u7814\u7a76\u4e2d\uff0c\u901a\u5e38\u9700\u8981\u5f15\u5165\u76f8\u5e94\u7684\u5bfc\u5411\u57fa\u56e2\u3001\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u5242\u6216\u5316\u5b66\u6c27\u5316\u5242\uff0c\u540c\u65f6\uff0c\u5e95\u7269\u5e94\u7528\u8303\u56f4\u8f83\u4e3a\u6709\u9650\u3002\u4e3a\u89e3\u51b3\u4e0a\u8ff0\u95ee\u9898\uff0c\u8fd1\u65e5\uff0c\u53a6\u95e8\u5927\u5b66\u7684\u5f90\u6d77\u8d85\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5728\u65e0\u50ac\u5316\u5242\u4e0e\u65e0\u5916\u90e8\u6c27\u5316\u5242\u4ee5\u53ca\u8fde\u7eed\u6d41\u52a8\u7684\u6761\u4ef6\u4e0b\u8fdb\u884c\u7684\u7535\u5316\u5b66\u82b3\u9999C-H\u81a6C-H\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b9e\u73b0\u4e00\u7cfb\u5217\u82b3\u57fa\u81a6C-H\u7c7b\u5316\u5408\u7269\u7684\u6784\u5efa\u3002\u5728\u8fd9\u4e00\u5168\u65b0\u7684\u7535\u5316\u5b66\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u7b56\u7565\u4e2d\uff0c\u901a\u8fc7\u82b3\u57fa\u5316\u5408\u7269\u4e0e\u9633\u6781\u4ea7\u751f\u7684P-\u81ea\u7531\u57fa\u6b63\u79bb\u5b50\u4e4b\u95f4\u7684\u53cd\u5e94\u8fc7\u7a0b\uff0c\u8fdb\u800c\u5f62\u6210\u76f8\u5e94\u7684C-P\u952e\u3002\u540c\u65f6\uff0c\u901a\u8fc7\u5177\u6709\u9ad8\u5ea6\u53cd\u5e94\u6d3b\u6027\u7684P-\u81ea\u7531\u57fa\u6b63\u79bb\u5b50\u4e0e\u6e29\u548c\u7684\u6709\u673a\u7535\u5408\u6210\u53cd\u5e94\u6761\u4ef6\u7684\u7ed3\u5408\uff0c\u8fdb\u800c\u4f7f\u4e00\u7cfb\u5217\u5177\u6709\u4e0d\u540c\u7535\u5b50\u7279\u6027\u7684\u82b3\u57fa\u5316\u5408\u7269\u80fd\u591f\u6709\u6548\u5730\u53c2\u4e0e\u4e0a\u8ff0\u7684\u81a6\u9178\u916f\u5316\u8fc7\u7a0b\u3002\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u8fd9\u4e00\u5168\u65b0\u7684\u81a6\u9178\u916f\u5316\u7b56\u7565\u8fdb\u4e00\u6b65\u5e94\u7528\u4e8e\u5404\u7c7b\u590d\u6742\u5929\u7136\u4ea7\u7269\u4e0e\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u7684\u9009\u62e9\u6027\u540e\u671f\u5b98\u80fd\u56e2\u5316\u8fc7\u7a0b\u7684\u76f8\u5173\u7814\u7a76\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u7535\u5316\u5b66\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u7b56\u7565\u540c\u6837\u80fd\u591f\u987a\u5229\u5b8c\u6210\u76f8\u5e94\u7684\u514b\u7ea7\u89c4\u6a21\u53cd\u5e94\uff0c\u8fdb\u800c\u8868\u660e\u8fd9\u4e00\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u3002 Electrochemical C-H phosphorylation of arenes in continuous flow suitable for late-stage functionalization H. Long, C. Huang, Y. Zheng, Z. Li, L. Jie, J. Song, S. Zhu, H. C. Xu, Nat. Commun. 2021, ASAP doi: 10.1038\/s41467-021-26960-y. \u6b63\u6587 \u82b3\u57fa\u78f7\u5316\u5408\u7269\u76ee\u524d\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u533b\u836f\u5316\u5b66\u3001\u6750\u6599\u79d1\u5b66\u4ee5\u53ca\u50ac\u5316\u914d\u4f53\u4e0eLewis\u9178\u50ac\u5316\u9886\u57df\u7684\u76f8\u5173\u7814\u7a76\u3002\u4e0e\u4f20\u7edf\u7684Hirao\u53cd\u5e94\u65b9\u6cd5\u5b66[1]\u76f8\u6bd4\uff0cC-H\u81a6\u9178\u916f\u5316\u7b56\u7565\u66f4\u52a0\u5177\u6709\u5438\u5f15\u529b\uff0c\u5e76\u4e14\u80fd\u591f\u6709\u6548\u5730\u907f\u514d\u76f8\u5173\u5e95\u7269\u7684\u9884\u5b98\u80fd\u56e2\u5316\u6b65\u9aa4\u3002\u76ee\u524d\uff0c\u5bf9\u4e8e\u975e\u7535\u5316\u5b66\u6761\u4ef6\u4e0b\u7684\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u65b9\u6cd5\u5b66\u7684\u76f8\u5173\u7814\u7a76\u00a0(Fig. 1a-b)\uff0c\u5df2\u7ecf\u6709\u8bf8\u591a\u7684\u6587\u732e\u62a5\u9053[2]-[4]\u3002\u7136\u800c\uff0c\u4e0a\u8ff0\u7684\u5408\u6210\u8f6c\u5316\u8fc7\u7a0b\u4e2d\uff0c\u901a\u5e38\u9700\u8981\u52a0\u5165\u8fc7\u91cf\u7684\u82b3\u57fa\u5e95\u7269\uff0c\u800c\u4e14\u5e95\u7269\u5e94\u7528\u8303\u56f4\u5341\u5206\u6709\u9650\u3002 \u540c\u65f6\uff0c\u8fd1\u5e74\u6765\uff0c\u7535\u5316\u5b66\u6761\u4ef6\u4e0b\u7684\u5404\u7c7b\u5bcc\u7535\u5b50\u6742\u82b3\u57fa\u5316\u5408\u7269[5]\u4ee5\u53ca\u5177\u6709\u5bfc\u5411\u57fa\u56e2\u7684\u82b3\u57fa\u5316\u5408\u7269[6]\u7684C-H\u81a6\u9178\u916f\u5316\u65b9\u6cd5\u5b66\u7684\u76f8\u5173\u7814\u7a76\u5df2\u7ecf\u53d6\u5f97\u8f83\u5927\u8fdb\u5c55\u3002\u7136\u800c\uff0c\u4e0a\u8ff0\u7684\u7535\u5316\u5b66C-H\u81a6\u9178\u916f\u5316\u7b56\u7565\u5bf9\u4e8e\u7f3a\u7535\u5b50\u7684\u82b3\u57fa\u5e95\u7269\uff0c\u5219\u9700\u8981\u91c7\u7528\u5404\u7c7b\u91d1\u5c5e\u50ac\u5316\u5242\uff0c\u540c\u65f6\u9700\u8981\u9009\u62e9\u5177\u6709\u4e09\u7535\u6781\u914d\u7f6e\u7684\u65e0\u9694\u819c\u7535\u89e3\u69fd[7]-[11]\u3002 \u63a5\u4e0b\u6765\uff0c\u53d7\u5230\u901a\u8fc7\u80fa\u57fa\u81ea\u7531\u57fa (aminyl radical)\u8d28\u5b50\u5316\u5f62\u6210\u7684\u80fa\u6b63\u79bb\u5b50\u81ea\u7531\u57fa (aminium radical)\u80fd\u591f\u663e\u8457\u63d0\u9ad8\u03c0-\u4f53\u7cfb\u53cd\u5e94\u6d3b\u6027\u7684\u76f8\u5173\u7814\u7a76\u62a5\u9053[12]-[13]\u7684\u542f\u53d1\uff0c\u4f5c\u8005\u8bbe\u60f3\uff0c\u4e0eP-\u81ea\u7531\u57fa\u76f8\u6bd4\uff0cP-\u81ea\u7531\u57fa\u6b63\u79bb\u5b50\u5177\u6709\u66f4\u9ad8\u7684\u53cd\u5e94\u6d3b\u6027\uff0c\u8fdb\u800c\u80fd\u591f\u4e0e\u5404\u7c7b\u7f3a\u7535\u5b50\u82b3\u57fa\u5e95\u7269\u8fdb\u884c\u6709\u6548\u7684\u53cd\u5e94 (Fig. 1c)\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u8bbe\u60f3\uff0c\u91c7\u7528\u8fde\u7eed\u6d41\u52a8\u7684\u7535\u5316\u5b66\u53cd\u5e94\u5668\uff0c\u53ef\u80fd\u66f4\u52a0\u6709\u5229\u4e8eP-\u81ea\u7531\u57fa\u6b63\u79bb\u5b50\u7684\u5f62\u6210\uff0c\u5e76\u901a\u8fc7\u82b3\u57fa\u5e95\u7269\u7684\u6355\u83b7\uff0c\u5f62\u6210\u76f8\u5e94\u7684\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u4ea7\u7269\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7684\u7814\u7a76\u8bbe\u60f3\uff0c\u53a6\u95e8\u5927\u5b66\u7684\u5f90\u6d77\u8d85\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5728\u8fde\u7eed\u6d41\u52a8\u6761\u4ef6\u4e0e\u65e0\u50ac\u5316\u5242\u4ee5\u53ca\u65e0\u5916\u90e8\u6c27\u5316\u5242\u5b58\u5728\u6761\u4ef6\u4e0b\u8fdb\u884c\u7684\u7535\u5316\u5b66\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u7684\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u987a\u5229\u5b8c\u6210\u4e00\u7cfb\u5217\u82b3\u57fa\u81a6\u9178\u916f\u5206\u5b50\u7684\u6784\u5efa (Fig. 1d)\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u75281\u4e0eP(OEt)3\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u81a6\u9178\u916f\u5316\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u5728\u77f3\u58a8\u4f5c\u4e3a\u9633\u6781\uff0cPt\u4f5c\u4e3a\u9634\u6781\u7684\u65e0\u9694\u819c\u8fde\u7eed\u6d41\u52a8\u7535\u89e3\u69fd\u4e2d\uff0c\u91c7\u7528HBF4\u4f5c\u4e3a\u9178\u6027\u6dfb\u52a0\u5242\uff0cH2O\u4f5c\u4e3a\u6dfb\u52a0\u5242\uff0cMeCN\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u6d41\u901f\u4e3a0.2 ml\/min-1\uff0c\u63a7\u5236\u7535\u6d41\u4e3a45-55 mA\uff0c\u6700\u7ec8\u83b7\u5f9770%\u6536\u7387\u7684\u81a6\u9178\u916f\u5316\u4ea7\u72692\u3002 \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u9996\u5148\u5bf9\u4e00\u7cfb\u5217\u82b3\u57fa\u5e95\u7269\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u8003\u5bdf (Fig. 2)\u3002\u7814\u7a76\u8868\u660e\uff0c\u4e00\u7cfb\u5217\u5e26\u6709\u4f9b\u7535\u5b50\u4e0e\u5438\u7535\u5b50\u57fa\u56e2\u53d6\u4ee3\u7684\u82b3\u57fa\u5e95\u7269\u5747\u80fd\u8f83\u597d\u5730\u4e0e\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u517c\u5bb9\uff0c\u5e76\u83b7\u5f97\u76f8\u5e94\u7684\u81a6\u9178\u916f\u5316\u4ea7\u72693–28\u00a0(26-94%\u00a0\u6536\u7387)\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cC-P\u952e\u5f62\u6210\u8fc7\u7a0b\u7684\u533a\u57df\u9009\u62e9\u6027\u4e0eFriedel-Crafts\u53cd\u5e94\u7c7b\u4f3c\uff0c\u5373\u82b3\u57fa\u5e95\u7269\u4e2d\u65e0\u9ad8\u5ea6\u7acb\u4f53\u4f4d\u963b\u57fa\u56e2\u5b58\u5728\u65f6\uff0c\u53cd\u5e94\u4f18\u5148\u5728\u4f9b\u7535\u5b50\u57fa\u56e2\u7684\u90bb\u4f4d\u6216\u5bf9\u4f4d\u8fdb\u884c\u3002\u4e4b\u540e\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c2-\u53d6\u4ee3\u567b\u5429\u5e95\u7269\uff0c\u540c\u6837\u80fd\u591f\u6709\u6548\u5730\u5b8c\u6210\u4e0a\u8ff0\u7684\u81a6\u9178\u916f\u5316\u8fc7\u7a0b\uff0c\u5e76\u83b7\u5f97\u76f8\u5e94\u76844-\u81a6\u9178\u916f\u4ea7\u726929\u4e0e30\u3002\u63a5\u4e0b\u6765\uff0c\u8be5\u5c0f\u7ec4\u8fdb\u4e00\u6b65\u5bf9\u4e00\u7cfb\u5217\u4e9a\u78f7\u9178\u916f\u7684\u5e95\u7269\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002\u4f5c\u8005\u53d1\u73b0\uff0c\u4e00\u7cfb\u5217\u5177\u6709\u4e0d\u540c\u4e00\u7ea7\u70f7\u57fa\u94fe\u7684\u4e9a\u78f7\u9178\u4e09\u70f7\u57fa\u916f\u5e95\u7269\uff0c\u5747\u80fd\u591f\u987a\u5229\u5730\u53c2\u4e0e\u4e0a\u8ff0\u7684\u81a6\u9178\u916f\u5316\u8fc7\u7a0b\uff0c\u5e76\u83b7\u5f97\u76f8\u5e94\u7684\u76ee\u6807\u4ea7\u726931–36\u00a0(45-77%\u00a0\u6536\u7387)\u3002\u6b64\u5916\uff0c\u7814\u7a76\u53d1\u73b0\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u81a6\u9178\u916f\u5316\u7b56\u7565\u540c\u6837\u80fd\u591f\u826f\u597d\u5730\u5e94\u7528\u4e8e\u5404\u7c7b\u590d\u6742\u5929\u7136\u4ea7\u7269\u4ee5\u53ca\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269 (37–46)\u7684\u540e\u671f\u5b98\u80fd\u56e2\u5316\u8fc7\u7a0b\u3002\u540c\u65f6\uff0c\u8be5\u5c0f\u7ec4\u8fdb\u4e00\u6b65\u89c2\u5bdf\u5230\uff0c\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u5bf9\u4e8e\u4e00\u7cfb\u5217\u5177\u6709\u591a\u91cd\u82b3\u73af\u5b58\u5728\u7684\u82b3\u57fa\u5316\u5408\u7269\uff0c\u5176\u81a6\u9178\u916f\u5316\u8fc7\u7a0b\u5219\u4f18\u5148\u9009\u62e9\u5728\u6700\u4e3a\u5bcc\u7535\u5b50\u7684\u82b3\u73af\u4e2d\u8fdb\u884c (38\u300140\u300141\u4e0e46)\u3002 \u4e4b\u540e\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u5bf9\u4e0a\u8ff0\u81a6\u9178\u916f\u5316\u7b56\u7565\u7684\u5408\u6210\u5b9e\u7528\u6027\u8fdb\u884c\u7814\u7a76 (Fig. 3)\u3002\u9996\u5148\uff0c\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c\u5c06\u5747\u4e09\u7532\u82ef\u5e95\u7269\u3001P(OEt)3\u7684MeCN\u6eb6\u6db2\u4ee5\u53caHBF4\u6dfb\u52a0\u5242\u3001H2O-MeCN\u6df7\u5408\u6eb6\u5242\u5206\u522b\u901a\u8fc7\u91c7\u7528\u4e24\u91cd\u5e73\u884c\u7684\u8fde\u7eed\u6d41\u52a8\u7535\u89e3\u69fd\u6784\u6210\u7684\u53cd\u5e94\u5668\u8fdb\u884c\u5145\u5206\u6df7\u5408\u4e4b\u540e\uff0c\u80fd\u591f\u987a\u5229\u5b8c\u6210\u514b\u7ea7\u89c4\u6a21 (214 mmol\u7684)\u81a6\u9178\u916f\u5316\u53cd\u5e94\uff0c\u5e76\u4ee5\u826f\u597d\u7684\u53cd\u5e94\u6536\u7387 (83%)\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u4e09\u7532\u82ef\u57fa\u81a6\u9178\u916f\u4ea7\u7269 27\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u89c2\u5bdf\u5230\uff0c\u901a\u8fc7\u4e0a\u8ff0\u81a6\u9178\u916f\u5316\u7b56\u7565\u83b7\u5f97\u7684\u7532\u57fa\u81a6\u9178\u916f\u4ea7\u726927\u80fd\u591f\u6709\u6548\u5730\u8f6c\u5316\u4e3a\u5176\u5b83\u4e0d\u540c\u7c7b\u578b\u7684\u6709\u673a\u78f7\u780c\u575747-54\u3002 \u63a5\u4e0b\u6765\uff0c\u4e3a\u63d0\u51fa\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406\uff0c\u4f5c\u8005\u8fdb\u884c\u4e00\u7cfb\u5217\u76f8\u5173\u7684\u5b9e\u9a8c\u7814\u7a76 (Fig. 4)\u3002\u9996\u5148\uff0c\u4f5c\u8005\u901a\u8fc7P(OEt)3\u3001\u82b3\u57fa\u5e95\u72691\u4ee5\u53caHPO(OEt)2\u7684CV\u5b9e\u9a8c\u8868\u660e\uff0c\u5728\u4e0a\u8ff0\u7684\u4e09\u79cd\u6709\u673a\u78f7\u5206\u5b50\u4e2d\uff0cP(OEt)3\u00a0(Ep\/2\u00a0= 1.50 V vs SCE)\u80fd\u591f\u6700\u4e3a\u5bb9\u6613\u5730\u53c2\u4e0e\u76f8\u5e94\u7684\u6c27\u5316\u8fc7\u7a0b (Fig. 4a)\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u901a\u8fc7\u5bf9\u82b3\u57fa\u5e95\u72691\u4e0eP(OEt)3\u7684\u53cd\u5e94\u6df7\u5408\u7269\uff0c\u5728\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u4ee5\u53ca\u65e0\u6c34\u5b58\u5728\u65f6\u7684\u76f8\u517331P-NMR\u8c31\u56fe\u5206\u6790 (Fig. 4b)\u8868\u660e\uff0cP(OEt)3\u5728\u65e0\u6c34\u5b58\u5728\u7684\u6761\u4ef6\u4e0b\uff0c\u80fd\u591f\u5206\u89e3\u4e3a\u591a\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u6709\u673a\u542b\u78f7\u4e2d\u95f4\u4f53\u3002\u76f8\u53cd\u5730\uff0c\u5728\u6807\u51c6\u6761\u4ef6\u4e0b\uff0c\u901a\u8fc731P-NMR\u5206\u6790\uff0c\u5219\u80fd\u591f\u6210\u529f\u6307\u8ba4\u51fa\u4e09\u79cd\u4e3b\u8981\u7684\u6709\u673a\u78f7\u4e2d\u95f4\u4f53\uff0c\u5373\u5316\u5408\u72692\u3001HPO(OEt)2\u4e0eOP(OEt)3\u3002\u540c\u65f6\uff0c\u7531\u4e8e\u4e9a\u78f7\u9178\u4e09\u70f7\u57fa\u916f\u5728\u9178\u7684\u4fc3\u8fdb\u4e0b\uff0c\u80fd\u591f\u8fc5\u901f\u6c34\u89e3\uff0c\u5f62\u6210\u76f8\u5e94\u7684H-\u78f7\u9178\u916f (H-phosphonate)\uff0c\u56e0\u6b64\uff0c\u4f5c\u8005\u89c2\u5bdf\u5230\uff0c\u5728P(OEt)3\u4e0eHPO(OEt)2\u5b58\u5728\u4ee5\u53ca\u672a\u52a0\u5165\u6c34\u7684\u6761\u4ef6 (\u53cd\u5e94\u6761\u4ef6II\u4e0e\u00a0III)\u4e0b\uff0c\u91c7\u7528\u82b3\u57fa\u5e95\u72691\u8fdb\u884c\u7684\u81a6\u9178\u916f\u5316\u8fc7\u7a0b\u4e2d\uff0c\u57282\u00a0eq. HPO(OEt)2\u5b58\u5728\u4e0b\uff0c\u80fd\u591f\u83b7\u5f9758%\u7684\u53cd\u5e94\u6536\u7387\uff1b\u800c\u57280.2\u00a0eq. HPO(OEt)2\u5b58\u5728\u4e0b\uff0c\u5219\u80fd\u591f\u83b7\u5f97\u66f4\u52a0\u4f18\u826f\u7684\u53cd\u5e94\u6536\u7387 (78%, Fig. 4b)\u3002\u540c\u65f6\uff0c\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c\u5728\u6761\u4ef6II\u4e0e\u00a0III\u4e2d\uff0c\u53cd\u5e94\u6df7\u5408\u7269\u768431P-NMR\u8c31\u56fe\u4e0e\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u4e0b\u768431P-NMR\u8c31\u56fe\u5341\u5206\u7c7b\u4f3c\u3002 \u4e4b\u540e\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u82b3\u57fa\u5e95\u72691\u5728P(OEt)3\u4e0eHPO(OnBu)2\u5b58\u5728\u4e0b\u8fdb\u884c\u7684\u7535\u89e3\u8fc7\u7a0b\u4e2d\uff0c\u5219\u83b7\u5f9751%\u6536\u7387\u7684\u81a6\u9178\u916f\u5316\u4ea7\u72692\u4ee5\u53ca\u75d5\u91cf\u7684\u4ea7\u726955\u00a0(Fig. 4c)\uff0c\u8fdb\u800c\u8868\u660e\u81a6\u9178\u916f\u4ea7\u7269\u4e2d\u7684PO(OR)2\u57fa\u56e2\u6e90\u81ea\u4e8eP(OR)3\u800c\u975eHPO(OR)2\u3002\u540c\u65f6\uff0c\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c\u53cd\u5e94\u6df7\u5408\u7269\u4e2d\u52a0\u5165H218O\u65f6\uff0c\u5728\u81a6\u9178\u916f\u5316\u4ea7\u72692\u4e2d\u5e76\u672a\u68c0\u6d4b\u51fa18O \u7684\u5b58\u5728 (Fig. 4d)\u3002\u7efc\u4e0a\u5b9e\u9a8c\u89c2\u5bdf\u8868\u660e\uff0cHPO(OR)2\u7684\u5b58\u5728\u5bf9\u4e8eC-H\u81a6\u9178\u916f\u5316\u53cd\u5e94\u7684\u987a\u5229\u8fdb\u884c\u5c24\u4e3a\u5173\u952e\u3002\u7136\u800c\uff0c\u53cd\u5e94\u8fc7\u7a0b\u4e2dHPO(OR)2\u7684\u5177\u4f53\u4f5c\u7528\u5219\u4ecd\u6709\u5f85\u6df1\u5165\u7814\u7a76\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u901a\u8fc7\u82ef\u4e0e\u82ef-d6\u4e4b\u95f4\u5206\u5b50\u95f4\u7ade\u4e89\u53cd\u5e94\u5b9e\u9a8c\uff0c\u89c2\u5bdf\u5230KIE\u4e3a1.0\uff0c\u8fdb\u800c\u8868\u660e\uff0c\u7535\u89e3\u53cd\u5e94\u7684\u51b3\u901f\u6b65\u9aa4\u4e2d\u5e76\u672a\u6d89\u53caC(aryl)-H\u952e\u7684\u65ad\u88c2 (Fig.\u00a04e)\u3002 \u57fa\u4e8e\u4e0a\u8ff0\u7814\u7a76\uff0c\u4f5c\u8005\u63d0\u51fa\u4e00\u79cd\u53ef\u80fd\u7684\u53cd\u5e94\u673a\u7406 (Fig.\u00a04f)\u3002\u9996\u5148\uff0c\u901a\u8fc7\u4e9a\u78f7\u9178\u4e09\u70f7\u57fa\u916f56\u7684\u9633\u6781\u6c27\u5316\u8fc7\u7a0b\uff0c\u5f62\u6210\u76f8\u5e94\u7684P-\u81ea\u7531\u57fa\u6b63\u79bb\u5b5057\uff0c\u518d\u901a\u8fc757\u4e0e\u82b3\u57fa\u5e95\u726958\u4f5c\u7528\uff0c\u5f62\u6210\u76f8\u5e94\u7684\u8fdc\u7a0b\u81ea\u7531\u57fa\u6b63\u79bb\u5b5059\u3002\u4e4b\u540e\uff0c59\u7ecf\u5386\u8fdb\u4e00\u6b65\u7684\u9633\u6781\u6c27\u5316\u4ee5\u53ca\u540e\u7eed\u7684\u53bb\u8d28\u5b50\u5316\u8fc7\u7a0b\uff0c\u5f62\u6210phosphonium\u4e2d\u95f4\u4f5360\u3002\u63a5\u4e0b\u6765\uff0c\u901a\u8fc7P(OR)3\u6c34\u89e3\u6216\u53cd\u5e94\u540e\u5904\u7406\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684\u6c34\u6216\u9187\u5206\u5b50\u5bf9\u4e8e\u4e2d\u95f4\u4f5360\u7684\u4eb2\u6838\u8fdb\u653b\u8fc7\u7a0b\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u81a6\u9178\u916f\u5316\u4ea7\u726961\u3002\u540c\u65f6\uff0c\u5728\u9178\u6027\u6761\u4ef6\u4e0b\uff0c\u53cd\u5e94\u6df7\u5408\u7269\u4e2d\u5927\u91cf\u5b58\u5728\u7684\u8d28\u5b50\u80fd\u591f\u5728Pt\u9634\u6781\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u8fd8\u539f\u6790\u6c22\u8fc7\u7a0b\uff0c\u5f62\u6210H2\u3002\u6b64\u5916\uff0c\u9178\u6027\u6dfb\u52a0\u5242HBF4\u9664\u80fd\u591f\u4fc3\u8fdbP(OR)3\u7684\u6c34\u89e3\u4e4b\u5916\uff0c\u540c\u6837\u80fd\u591f\u4f5c\u4e3a\u652f\u6301\u7535\u89e3\u8d28\u4ee5\u53ca\u6790\u6c22\u8fc7\u7a0b\u4e2d\u7684\u8d28\u5b50\u6e90\uff0c\u8fdb\u800c\u6709\u6548\u907f\u514d\u7f3a\u7535\u5b50\u7684\u4e2d\u95f4\u4f5360\u4ee5\u53ca\u76ee\u6807\u5206\u5b5061\u8fdb\u4e00\u6b65\u53c2\u4e0e\u540e\u7eed\u7684\u9634\u6781\u8fd8\u539f\u8fc7\u7a0b\u3002\u5e76\u4e14\uff0c\u901a\u8fc7P(OR)3\u6c34\u89e3\u539f\u4f4d\u5f62\u6210\u7684HPO(OR)2\u4e2d\u95f4\u4f53\uff0c\u540c\u6837\u53ef\u80fd\u4e0e\u81ea\u7531\u57fa\u6b63\u79bb\u5b5057\u901a\u8fc7\u540e\u7eed\u7684\u53ef\u9006\u53cd\u5e94\u6b65\u9aa4\uff0c\u5f62\u6210\u76f8\u5e94\u7684\u52a0\u5408\u726962\uff0c\u8fdb\u800c\u6709\u6548\u5730\u51cf\u5f3157\u7684\u8fdb\u4e00\u6b65\u5206\u89e3\u3002\u56e0\u6b64\uff0c\u81ea\u7531\u57fa\u6b63\u79bb\u5b5057\u80fd\u591f\u987a\u5229\u5730\u53c2\u4e0e\u540e\u7eed\u7684\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u8fc7\u7a0b\u3002 \u603b\u7ed3 \u53a6\u95e8\u5927\u5b66\u7684\u5f90\u6d77\u8d85\u6559\u6388\u8bfe\u9898\u7ec4\u5728\u8fde\u7eed\u6d41\u52a8\u7684\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u82b3\u9999C-H\u81a6\u9178\u916f\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u3002\u53cd\u5e94\u8fc7\u7a0b\u4e2d\uff0c\u65e0\u9700\u52a0\u5165\u76f8\u5e94\u7684\u5206\u5b50\u50ac\u5316\u5242\u4ee5\u53ca\u4f20\u7edf\u7684\u5316\u5b66\u6c27\u5316\u5242\u3002\u540c\u65f6\uff0c\u8fd9\u4e00\u5168\u65b0\u7684C-H\u81a6\u9178\u916f\u5316\u7b56\u7565\u5177\u6709\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\u3001\u5e95\u7269\u5e94\u7528\u8303\u56f4\u5e7f\u6cdb\u3001\u9ad8\u5ea6\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u9ad8\u7b49\u4f18\u52bf\u3002 \u53c2\u8003\u6587\u732e [1] C. S.\u00a0Demmer, N. Krogsgaard-Larsen, L. Bunch, Chem. Rev. 2011, 111, 7981.\u00a0doi:\u00a010.1021\/cr2002646. 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