{"id":40871,"date":"2021-12-30T08:00:16","date_gmt":"2021-12-30T00:00:16","guid":{"rendered":"\/\/www.gsbet888.com\/?p=40871"},"modified":"2022-01-26T15:10:49","modified_gmt":"2022-01-26T07:10:49","slug":"%e5%8d%97%e4%ba%ac%e5%a4%a7%e5%ad%a6%e5%8f%b2%e5%a3%ae%e5%bf%97%e8%af%be%e9%a2%98%e7%bb%84angew%ef%bc%9a-%e9%95%8d%e5%82%ac%e5%8c%96%e7%9a%84%e7%ab%8b%e4%bd%93%e4%b8%8e%e5%af%b9%e6%98%a0%e9%80%89","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2021\/12\/%e5%8d%97%e4%ba%ac%e5%a4%a7%e5%ad%a6%e5%8f%b2%e5%a3%ae%e5%bf%97%e8%af%be%e9%a2%98%e7%bb%84angew%ef%bc%9a-%e9%95%8d%e5%82%ac%e5%8c%96%e7%9a%84%e7%ab%8b%e4%bd%93%e4%b8%8e%e5%af%b9%e6%98%a0%e9%80%89.html","title":{"rendered":"\u5357\u4eac\u5927\u5b66\u53f2\u58ee\u5fd7\u8bfe\u9898\u7ec4Angew\uff1a \u954d\u50ac\u5316\u7684\u7acb\u4f53\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u4ea4\u53c9\u5076\u8054\u65b9\u6cd5\u5b66\u7814\u7a76"},"content":{"rendered":"

\u5bfc\u8bfb\uff1a<\/h4>\n

\u8fd1\u65e5\uff0c\u5357\u4eac\u5927\u5b66\u7684\u53f2\u58ee\u5fd7\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7C-F\u952e\u6d3b\u5316\u9014\u5f84\u8fdb\u884c\u7684\u7acb\u4f53\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u4eb2\u7535\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u65b9\u6cd5\u5b66\u3002\u5176\u4e2d\uff0c\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u91c7\u7528\u624b\u6027\u954d\u914d\u5408\u7269\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cB2<\/sub>pin2<\/sub>\u4f5c\u4e3a\u5316\u5b66\u8ba1\u91cf\u7684\u8fd8\u539f\u5242\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u5404\u7c7b\u5916\u6d88\u65cb\u82c4\u57fa\u4eb2\u7535\u5e95\u7269\u4e0e\u5055\u4e8c\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u4e4b\u95f4\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4ea4\u53c9\u5076\u8054\u8fc7\u7a0b\uff0c\u5e76\u5728\u6e29\u548c\u7684\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u987a\u5229\u5b9e\u73b0\u4e00\u7cfb\u5217C(sp2<\/sup>)-C(sp3<\/sup>) \u952e\u7684\u6784\u5efa\u3002\u540c\u65f6\uff0c\u53cd\u5e94\u673a\u7406\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u4ea4\u53c9\u5076\u8054\u8fc7\u7a0b\u4e2d\u6d89\u53ca\u81ea\u7531\u57fa\u94fe\u53cd\u5e94\u6b65\u9aa4\uff0c\u5e76\u4e14\uff0c\u901a\u8fc7\u5055-\u4e8c\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u4e2d\u916f\u57fa\u56e2\u8f85\u52a9\u7684C-F\u952e\u5bf9\u4e8e\u954d\u914d\u5408\u7269\u7684\u6c27\u5316\u52a0\u6210\u8fc7\u7a0b\uff0c\u987a\u5229\u5b9e\u73b0\u76f8\u5173C-F\u952e\u7684\u6d3b\u5316\u3002<\/p>\n

Nickel-Catalyzed Stereo- and Enantioselective Cross-Coupling of gem<\/em>-Difluoroalkenes with Carbon Electrophiles by C-F Bond Activation<\/p>\n

Z. Zhu, L. Lin, J. Xiao, Z. Shi, Angew. Chem. Int. Ed<\/em>. 2021<\/strong>, ASAP doi:10.1002\/anie.202113209.<\/p><\/blockquote>\n

\"\"<\/a><\/p>\n

\u6b63\u6587\uff1a<\/p>\n

\u6709\u673a\u6c1f\u5316\u5408\u7269\u5c24\u5176\u5355\u6c1f\u70ef\u57fa\u5316\u5408\u7269\uff0c\u5df2\u7ecf\u5e7f\u6cdb\u7528\u4e8e\u6709\u673a\u5408\u6210\u5316\u5b66\u4ee5\u53ca\u533b\u836f\u7b49\u8bf8\u591a\u9886\u57df\u7684\u76f8\u5173\u7814\u7a76\u3002\u76ee\u524d\uff0c\u6709\u673a\u5408\u6210\u5316\u5b66\u5bb6\u5df2\u7ecf\u6210\u529f\u5f00\u53d1\u51fa\u591a\u79cd\u6784\u5efa\u5404\u7c7b\u5355\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u7684\u76f8\u5173\u53cd\u5e94\u7b56\u7565[1]-[9]<\/sup>\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u901a\u8fc7\u5055\u4e8c\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u7684C-F\u952e\u6d3b\u5316\u7b56\u7565\uff0c\u6784\u5efa\u5404\u7c7b\u5bf9\u6620\u5bcc\u96c6\u5355\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u7684\u53cd\u5e94\u65b9\u6cd5\u5b66\u7814\u7a76\uff0c\u81f3\u4eca\u5c1a\u672a\u6709\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053\u3002<\/p>\n

\u8fd9\u91cc\uff0c\u53d7\u5230\u4e0d\u5bf9\u79f0\u53bb\u6c1f\u5b98\u80fd\u56e2\u5316 (asymmetric defluorinative functionalization)\u53cd\u5e94\u65b9\u6cd5\u5b66 (Figure 1a-1b)[10]-[11]<\/sup>\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u5357\u4eac\u5927\u5b66\u7684\u53f2\u58ee\u5fd7\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u954d\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u5055\u4e8c\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u4e0e\u5916\u6d88\u65cb\u70f7\u57fa\u5364\u4e4b\u95f4\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u70ef\u4e19\u57fa\u7acb\u4f53\u751f\u6210\u4e2d\u5fc3\u7684\u5b98\u80fd\u56e2\u5316\u5355\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u7684\u6784\u5efa\uff0c\u5177\u5e76\u8868\u73b0\u51fa\u4f18\u826f\u7684\u7acb\u4f53\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u63a7\u5236 (Figure 1c)\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528\u5055\u4e8c\u6c1f\u70ef\u57fa\u5316\u5408\u72691a<\/strong>\u4e0e\u5916\u6d88\u65cb\u82c4\u57fa\u6c2f2a<\/strong>\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u5076\u8054\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528Ni-L6<\/strong>\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cB2<\/sub>pin2<\/sub>\u4f5c\u4e3a\u8fd8\u539f\u5242\uff0cK3<\/sub>PO4<\/sub>\u4f5c\u4e3a\u78b1\uff0cNaI\u4e0e4 \u00c5MS\u4f5c\u4e3a\u6dfb\u52a0\u5242\uff0c\u5728MeCN\u6eb6\u5242\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a30o<\/sup>C\uff0c\u5e76\u83b7\u5f9775%\u6536\u7387\u7684\u4e0d\u5bf9\u79f0\u5076\u8054\u4ea7\u72693aa <\/strong>(91% ee)\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u9996\u5148\u5bf9\u5404\u7c7b\u78b3\u4eb2\u7535\u5e95\u7269\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u8003\u5bdf (Table 2)\u3002\u7814\u7a76\u8868\u660e\uff0c\u4e00\u7cfb\u5217\u82ef\u73af\u4e2d\u5177\u6709\u4e0d\u540c\u4f9b\u7535\u5b50\u4e0e\u5438\u7535\u5b50\u57fa\u56e2\u53d6\u4ee3\u7684\u82c4\u57fa\u6c2f\u5e95\u7269\uff0c\u5747\u80fd\u591f\u8f83\u597d\u5730\u4e0e\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u517c\u5bb9\uff0c\u5e76\u83b7\u5f97\u76f8\u5e94\u7684\u624b\u6027\u4ea7\u72693aa<\/strong>–3al<\/strong>\uff0c(61-96% \u6536\u7387, 87-93 % ee)\u3002\u4e4b\u540e\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c\u8418\u57fa2j<\/strong>\u4ee5\u53ca\u6742\u82b3\u57fa\u53d6\u4ee3\u7684\u82c4\u57fa\u6c2f\u7c7b\u4f3c\u72692ak<\/strong>–2al<\/strong>\u540c\u6837\u80fd\u591f\u6709\u6548\u5730\u53c2\u4e0e\u4e0a\u8ff0\u7684\u5408\u6210\u8f6c\u5316\u8fc7\u7a0b\u3002\u540c\u65f6\uff0c\u8be5\u5c0f\u7ec4\u89c2\u5bdf\u5230\uff0c\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u5bf9\u4e8e\u03b2<\/em>-\u53d6\u4ee3\u7684\u82c4\u57fa\u6c2f\u5e95\u72692m-o<\/strong>\uff0c1-\u6c2f-1,2,3,4-\u56db\u6c22\u84182p<\/strong>\u4ee5\u53ca\u5b58\u5728\u53cc\u91cdC-Cl\u952e\u7684\u5e95\u72692q<\/strong>\uff0c\u540c\u6837\u80fd\u591f\u987a\u5229\u5730\u5b8c\u6210\u4e0a\u8ff0\u7684\u4eb2\u7535\u4ea4\u53c9\u5076\u8054\u8fc7\u7a0b\uff0c\u5e76\u83b7\u5f97\u76f8\u5e94\u7684\u4e0d\u5bf9\u79f0\u5076\u8054\u4ea7\u72693am<\/strong>–3aq<\/strong> (60-74% \u6536\u7387\uff0c85-98% ee)\u3002\u540c\u65f6\uff0c\u5bf9\u4e8e\u8fdc\u7aef\u5e26\u6709\u82b3\u57fa\u53d6\u4ee3\u7684\u70f7\u57fa\u4eb2\u7535\u5e95\u72692r<\/strong>\u540c\u6837\u80fd\u591f\u826f\u597d\u5730\u517c\u5bb9\uff0c\u5e76\u83b7\u5f97\u4e2d\u7b49\u7a0b\u5ea6\u7684\u53cd\u5e94\u6536\u7387\uff0c\u7136\u800c\uff0c\u7f3a\u4e4f\u826f\u597d\u7684\u5bf9\u6620\u9009\u62e9\u6027\u63a7\u5236\u3002\u6b64\u5916\uff0c\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u4f53\u7cfb\u5bf9\u4e8e\u96cc\u916e\u884d\u751f\u7684\u4eb2\u7535\u5e95\u72692s<\/strong>\uff0c\u540c\u6837\u80fd\u591f\u4ee5\u826f\u597d\u7684\u53cd\u5e94\u6536\u7387\u4e0e\u4f18\u826f\u7684\u7acb\u4f53\u9009\u62e9\u6027\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u5076\u8054\u4ea7\u72693as<\/strong>\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217\u5055\u4e8c\u6c1f\u70ef\u57fa\u5e95\u7269\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76 (Table 3)\u3002\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c\u4e00\u7cfb\u5217\u82ef\u73af\u4f4d\u7f6e\u5177\u6709\u4f9b\u7535\u5b50\u4ee5\u53ca\u5438\u7535\u5b50\u57fa\u56e2\u53d6\u4ee3\u7684\u5055\u4e8c\u6c1f\u70ef\u57fa\u5e95\u7269\uff0c\u5747\u80fd\u8f83\u597d\u5730\u4e0e\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u517c\u5bb9\uff0c\u5e76\u80fd\u591f\u4ee5\u9ad8\u5ea6\u7684\u7acb\u4f53\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u5076\u8054\u4ea7\u72693ba<\/strong>–3ia <\/strong>(59-80% \u6536\u7387, 88-91% ee)\u3002\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c\u5404\u7c7b\u5177\u6709\u6742\u73af\u57fa\u56e21j<\/strong>\u3001\u82c4\u57fa1k<\/strong>\u3001\u70f7\u57fa1l-n<\/strong>\u4ee5\u53ca\u916f\u57fa1o-1p<\/strong>\u53d6\u4ee3\u7684\u5055\u4e8c\u6c1f\u70ef\u57fa\u5e95\u7269\uff0c\u5747\u80fd\u591f\u83b7\u5f97\u826f\u597d\u7684\u53cd\u5e94\u6536\u7387\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u63a7\u5236\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u65e0\u5bfc\u5411\u57fa\u56e2\u5b58\u5728\u7684\u5055\u4e8c\u6c1f\u70ef\u57fa\u5e95\u72691q-1r<\/strong>\uff0c\u5219\u65e0\u6cd5\u83b7\u5f97\u9884\u671f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5076\u8054\u4ea7\u7269\u3002\u800c\u5bf9\u4e8e\u5177\u6709\u7fa7\u9178\u57fa\u56e2\u7684\u5e95\u72691s<\/strong>\uff0c\u5219\u4ec5\u80fd\u591f\u83b7\u5f97\u75d5\u91cf\u7684\u5076\u8054\u4ea7\u7269\uff0c\u8fdb\u800c\u8868\u660e\u5728\u5055\u4e8c\u6c1f\u70ef\u57fa\u5e95\u7269\u4e2d\uff0c\u916f\u57fa\u57fa\u56e2\u7684\u5b58\u5728\uff0c\u5bf9\u4e8e\u4e0a\u8ff0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u8fc7\u7a0b\u7684\u987a\u5229\u8fdb\u884c\u5c24\u4e3a\u5173\u952e\u3002<\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c\u5728\u4e0a\u8ff0\u7684\u6807\u51c6\u6761\u4ef6\u4e0b\u8fdb\u884c\u76841a<\/strong>\u4e0e2a<\/strong>\u7684\u514b\u7ea7\u89c4\u6a21\u5b9e\u9a8c\uff0c\u540c\u6837\u80fd\u591f\u83b7\u5f97\u826f\u597d\u7684\u53cd\u5e94\u6536\u7387\u4e0e\u4f18\u826f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u63a7\u5236\u3002\u4e4b\u540e\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u901a\u8fc7\u4e0a\u8ff0\u5bf9\u6620\u9009\u62e9\u6027\u5076\u8054\u8fc7\u7a0b\u83b7\u5f97\u7684\u624b\u6027\u5076\u8054\u4ea7\u72693aa<\/strong>\u80fd\u591f\u8fdb\u4e00\u6b65\u5b8c\u6210\u591a\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u5408\u6210\u8f6c\u5316\u8fc7\u7a0b (Scheme 1)\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u63a5\u4e0b\u6765\uff0c\u4e3a\u63d0\u51fa\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406\uff0c\u4f5c\u8005\u8fdb\u884c\u4e00\u7cfb\u5217\u76f8\u5173\u7684\u5b9e\u9a8c\u7814\u7a76 (Scheme 2)\u3002\u9996\u5148\uff0c\u8be5\u5c0f\u7ec4\u57281a<\/strong>\u4e0e2a<\/strong>\u7684\u6807\u51c6\u53cd\u5e94\u4f53\u7cfb\u4e2d\uff0c\u52a0\u5165\u81ea\u7531\u57fa\u6291\u5236\u5242TEMPO\u4ee5\u53caBHT\u65f6\uff0c\u89c2\u5bdf\u5230\u76f8\u5e94\u7684\u5076\u8054\u8fc7\u7a0b\u53d7\u5230\u5b8c\u5168\u6291\u5236\uff0c\u8fdb\u800c\u8868\u660e\u4e0a\u8ff0\u7684\u4e0d\u5bf9\u79f0\u5076\u8054\u8fc7\u7a0b\u4e2d\u6d89\u53ca\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53\u7684\u53c2\u4e0e (Scheme 2a)\u3002\u4e4b\u540e\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u5728\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c1a<\/strong>\u4e0e\u787c\u9178\u916f9<\/strong>\u4e4b\u95f4\u7684\u53cd\u5e94\u8fc7\u7a0b\u65e0\u6cd5\u83b7\u5f97\u9884\u671f\u7684\u5076\u8054\u4ea7\u72693aa<\/strong> (Scheme 2b)\uff1b\u800c\u4e14\uff0c\u901a\u8fc7\u787c\u9178\u916f10<\/strong>\u4e0e2a<\/strong>\u4e4b\u95f4\u7684\u53cd\u5e94\uff0c\u540c\u6837\u65e0\u6cd5\u83b7\u5f97\u9884\u671f\u7684\u5076\u8054\u4ea7\u726911 <\/strong>(Scheme 2c)\u3002\u901a\u8fc7\u8fd9\u4e00\u5b9e\u9a8c\u89c2\u5bdf\uff0c\u80fd\u591f\u6392\u9664\u901a\u8fc7\u539f\u4f4d\u5f62\u6210\u7684\u787c\u5316\u4ea7\u7269\u8fdb\u884c\u540e\u7eedSuzuki\u5076\u8054\u7684\u673a\u7406\u8def\u5f84\u3002\u63a5\u4e0b\u6765\uff0c\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c\u9009\u62e9\u624b\u6027\u82c4\u57fa\u6c2f\u5e95\u7269R<\/em>–2a<\/strong>\u65f6\uff0c\u5728\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u4f53\u7cfb\u4e2d\uff0c\u5219\u4ec5\u80fd\u591f\u83b7\u5f97\u5177\u6709\u6781\u4f4eee %\u7684\u5076\u8054\u4ea7\u72693aa <\/strong>(Scheme 2d)\u3002\u8fd9\u4e00\u4e8b\u5b9e\u8868\u660e\uff0c\u4e0a\u8ff0\u7684\u4e0d\u5bf9\u79f0\u5076\u8054\u8fc7\u7a0b\u4e2d\u6d89\u53ca\u901a\u8fc7\u82c4\u57fa\u6c2f\u7684SET\u8fc7\u7a0b\uff0c\u5f62\u6210\u7684\u82c4\u57fa\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53\u7684\u53c2\u4e0e\u3002<\/p>\n

 <\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\u3001\u524d\u671f\u5bf9\u4e8eNaI\u5728\u5076\u8054\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u7684\u5e94\u7528\u7814\u7a76[12]-[13]<\/sup>\u4ee5\u53ca\u954d\u914d\u5408\u7269A<\/strong>\u5206\u79bb (Figure 2)\u7684\u76f8\u5173\u6587\u732e\u62a5\u9053[12]<\/sup>\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406\u8def\u5f84 (Figure 3)\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u603b\u7ed3\uff1a\u5357\u4eac\u5927\u5b66\u7684\u53f2\u58ee\u5fd7\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u901a\u8fc7\u954d\u50ac\u5316\u5242\u53c2\u4e0e\u7684\u5916\u6d88\u65cb\u82c4\u57fa\u4eb2\u7535\u5e95\u7269\u4e0e\u5055\u4e8c\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u4e4b\u95f4\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4eb2\u7535\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u7b56\u7565\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u70ef\u4e19\u57fa\u7acb\u4f53\u751f\u6210\u4e2d\u5fc3\u7684\u5355\u6c1f\u70ef\u57fa\u884d\u751f\u7269\u7684\u6784\u5efa\u3002\u540c\u65f6\uff0c\u7814\u7a76\u8868\u660e\uff0c\u53cd\u5e94\u673a\u7406\u4e3b\u8981\u6d89\u53ca\u87af\u5408\u8f85\u52a9\u7684C-F\u952e\u6d3b\u5316\u8fc7\u7a0b\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/h4>\n[1] C. Ni, M. Hu, J. Hu, Chem. Rev. <\/em>2015<\/strong>, 115<\/em>, 765. doi: 10.1021\/cr5002386<\/a>.<\/p>\n[2] H. Amii, K. Uneyama, Chem. Rev. <\/em>2009<\/strong>, 109<\/em>, 2119. doi: 10.1021\/cr800388c<\/a>.<\/p>\n[3] J. Q. Wu, S. S. Zhang, H. Gao, Z. Qi, C. J. Zhou, W. W. Ji, Y. Liu, Y. Chen, Q. Li, X. Li, H. Wang, J. Am. Chem. Soc. <\/em>2017<\/strong>, 139<\/em>, 3537. doi: 10.1021\/jacs.7b00118<\/a>.<\/p>\n[4] W. Dai, H. Shi, X. Zhao, S. Cao, Org. Lett. <\/em>2016<\/strong>, 18<\/em>, 4284. doi: 10.1021\/acs.orglett.6b02026<\/a>.<\/p>\n[5] H. Sakaguchi, Y. Uetake, M. Ohashi, T. Niwa, S. Ogoshi, T. Hosoya, J. Am. Chem. Soc. <\/em>2017<\/strong>, 139<\/em>, 12855. doi: 10.1021\/jacs.7b08343<\/a>.<\/p>\n[6] H. Zhang, E. Wang, S. Geng, Z. Liu, Y. He, Q. Peng, Z. Feng, Angew. Chem. Int. Ed. <\/em>2021<\/strong>, 60, 10211. doi: 10.1002\/anie.202100049<\/a>.<\/p>\n[7] S. S. Yan, D. S.Wu, J. H.Ye, L. Gong, X. Zeng, C. K.Ran, Y. Y. Gui, J. Li, D. G. Yu, ACS Catal. <\/em>2019<\/strong>, 9<\/em>, 6987. doi: 10.1021\/acscatal.9b02351<\/a>.<\/p>\n[8] R. Kojima, K. Kubota, H. Ito, Chem. Commun. <\/em>2017<\/strong>, 53<\/em>, 10688. doi: 10.1039\/C7CC05225A<\/a>.<\/p>\n[9] Q. Ma, Y. Wang, G. C. Tsui, Angew. Chem. Int. Ed. <\/em>2020<\/strong>, 59<\/em>, 11293. doi: 10.1002\/anie.202002219<\/a>.<\/p>\n[10] T. W. Butcher, J. L. Yang, W. M. Amberg, N. B. Watkins, N. D. Wilkinson, J. F. Hartwig, Nature <\/em>2020<\/strong>, 583<\/em>, 548. doi: 10.1038\/s41586-020-2399-1<\/a>.<\/p>\n[11] X. Lu, Y. Wang, B. Zhang, J. J.Pi, X. X.Wang, T. J. Gong, B. Xiao, Y. Fu, J. Am. Chem. Soc. <\/em>2017<\/strong>, 139<\/em>, 12632. doi: 10.1021\/jacs.7b06469<\/a>.<\/p>\n[12] (a) I. Colon, D. R. Kelsey, J. Org. Chem. <\/em>1986<\/strong>, 51<\/em>, 2627. doi: 10.1021\/jo00364a002<\/a>.<\/p>\n

(b) M. R. Prinsell, D. A. Everson, D. J. Weix, Chem. Commun. <\/em>2010<\/strong>, 46<\/em>, 574. doi: 10.1039\/B922544G<\/a>.<\/p>\n[13] M. Ohashi, T. Kambara, T. Hatanaka, H.Saijo, R. Doi, S. Ogoshi, J. Am. Chem. Soc. <\/em>2011<\/strong>, 133<\/em>, 3256. doi: 10.1021\/ja109911p<\/a>.<\/p>\n

\u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/p>\n","protected":false},"excerpt":{"rendered":"\u5bfc\u8bfb\uff1a \u8fd1\u65e5\uff0c\u5357\u4eac\u5927\u5b66\u7684\u53f2\u58ee\u5fd7\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7C-F\u952e\u6d3b\u5316\u9014\u5f84\u8fdb\u884c\u7684\u7acb\u4f53\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u4eb2\u7535\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u65b9\u6cd5\u5b66\u3002\u5176\u4e2d\uff0c\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u91c7\u7528\u624b\u6027\u954d\u914d\u5408\u7269\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cB2pin2\u4f5c\u4e3a\u5316\u5b66\u8ba1\u91cf\u7684\u8fd8\u539f\u5242\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u5404\u7c7b\u5916\u6d88\u65cb\u82c4\u57fa\u4eb2\u7535\u5e95\u7269\u4e0e\u5055\u4e8c\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u4e4b\u95f4\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4ea4\u53c9\u5076\u8054\u8fc7\u7a0b\uff0c\u5e76\u5728\u6e29\u548c\u7684\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u987a\u5229\u5b9e\u73b0\u4e00\u7cfb\u5217C(sp2)-C(sp3) \u952e\u7684\u6784\u5efa\u3002\u540c\u65f6\uff0c\u53cd\u5e94\u673a\u7406\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u4ea4\u53c9\u5076\u8054\u8fc7\u7a0b\u4e2d\u6d89\u53ca\u81ea\u7531\u57fa\u94fe\u53cd\u5e94\u6b65\u9aa4\uff0c\u5e76\u4e14\uff0c\u901a\u8fc7\u5055-\u4e8c\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u4e2d\u916f\u57fa\u56e2\u8f85\u52a9\u7684C-F\u952e\u5bf9\u4e8e\u954d\u914d\u5408\u7269\u7684\u6c27\u5316\u52a0\u6210\u8fc7\u7a0b\uff0c\u987a\u5229\u5b9e\u73b0\u76f8\u5173C-F\u952e\u7684\u6d3b\u5316\u3002 Nickel-Catalyzed Stereo- and Enantioselective Cross-Coupling of gem-Difluoroalkenes with Carbon Electrophiles by C-F Bond Activation Z. Zhu, L. Lin, J. Xiao, Z. Shi, Angew. Chem. Int. Ed. 2021, ASAP doi:10.1002\/anie.202113209. \u6b63\u6587\uff1a \u6709\u673a\u6c1f\u5316\u5408\u7269\u5c24\u5176\u5355\u6c1f\u70ef\u57fa\u5316\u5408\u7269\uff0c\u5df2\u7ecf\u5e7f\u6cdb\u7528\u4e8e\u6709\u673a\u5408\u6210\u5316\u5b66\u4ee5\u53ca\u533b\u836f\u7b49\u8bf8\u591a\u9886\u57df\u7684\u76f8\u5173\u7814\u7a76\u3002\u76ee\u524d\uff0c\u6709\u673a\u5408\u6210\u5316\u5b66\u5bb6\u5df2\u7ecf\u6210\u529f\u5f00\u53d1\u51fa\u591a\u79cd\u6784\u5efa\u5404\u7c7b\u5355\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u7684\u76f8\u5173\u53cd\u5e94\u7b56\u7565[1]-[9]\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u901a\u8fc7\u5055\u4e8c\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u7684C-F\u952e\u6d3b\u5316\u7b56\u7565\uff0c\u6784\u5efa\u5404\u7c7b\u5bf9\u6620\u5bcc\u96c6\u5355\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u7684\u53cd\u5e94\u65b9\u6cd5\u5b66\u7814\u7a76\uff0c\u81f3\u4eca\u5c1a\u672a\u6709\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053\u3002 \u8fd9\u91cc\uff0c\u53d7\u5230\u4e0d\u5bf9\u79f0\u53bb\u6c1f\u5b98\u80fd\u56e2\u5316 (asymmetric defluorinative functionalization)\u53cd\u5e94\u65b9\u6cd5\u5b66 (Figure 1a-1b)[10]-[11]\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u5357\u4eac\u5927\u5b66\u7684\u53f2\u58ee\u5fd7\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u954d\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u5055\u4e8c\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u4e0e\u5916\u6d88\u65cb\u70f7\u57fa\u5364\u4e4b\u95f4\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u70ef\u4e19\u57fa\u7acb\u4f53\u751f\u6210\u4e2d\u5fc3\u7684\u5b98\u80fd\u56e2\u5316\u5355\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u7684\u6784\u5efa\uff0c\u5177\u5e76\u8868\u73b0\u51fa\u4f18\u826f\u7684\u7acb\u4f53\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u63a7\u5236 (Figure 1c)\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528\u5055\u4e8c\u6c1f\u70ef\u57fa\u5316\u5408\u72691a\u4e0e\u5916\u6d88\u65cb\u82c4\u57fa\u6c2f2a\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u5076\u8054\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528Ni-L6\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cB2pin2\u4f5c\u4e3a\u8fd8\u539f\u5242\uff0cK3PO4\u4f5c\u4e3a\u78b1\uff0cNaI\u4e0e4 \u00c5MS\u4f5c\u4e3a\u6dfb\u52a0\u5242\uff0c\u5728MeCN\u6eb6\u5242\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a30oC\uff0c\u5e76\u83b7\u5f9775%\u6536\u7387\u7684\u4e0d\u5bf9\u79f0\u5076\u8054\u4ea7\u72693aa (91% ee)\u3002 \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u9996\u5148\u5bf9\u5404\u7c7b\u78b3\u4eb2\u7535\u5e95\u7269\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u8003\u5bdf (Table 2)\u3002\u7814\u7a76\u8868\u660e\uff0c\u4e00\u7cfb\u5217\u82ef\u73af\u4e2d\u5177\u6709\u4e0d\u540c\u4f9b\u7535\u5b50\u4e0e\u5438\u7535\u5b50\u57fa\u56e2\u53d6\u4ee3\u7684\u82c4\u57fa\u6c2f\u5e95\u7269\uff0c\u5747\u80fd\u591f\u8f83\u597d\u5730\u4e0e\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u517c\u5bb9\uff0c\u5e76\u83b7\u5f97\u76f8\u5e94\u7684\u624b\u6027\u4ea7\u72693aa–3al\uff0c(61-96% \u6536\u7387, 87-93 % ee)\u3002\u4e4b\u540e\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c\u8418\u57fa2j\u4ee5\u53ca\u6742\u82b3\u57fa\u53d6\u4ee3\u7684\u82c4\u57fa\u6c2f\u7c7b\u4f3c\u72692ak–2al\u540c\u6837\u80fd\u591f\u6709\u6548\u5730\u53c2\u4e0e\u4e0a\u8ff0\u7684\u5408\u6210\u8f6c\u5316\u8fc7\u7a0b\u3002\u540c\u65f6\uff0c\u8be5\u5c0f\u7ec4\u89c2\u5bdf\u5230\uff0c\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u5bf9\u4e8e\u03b2-\u53d6\u4ee3\u7684\u82c4\u57fa\u6c2f\u5e95\u72692m-o\uff0c1-\u6c2f-1,2,3,4-\u56db\u6c22\u84182p\u4ee5\u53ca\u5b58\u5728\u53cc\u91cdC-Cl\u952e\u7684\u5e95\u72692q\uff0c\u540c\u6837\u80fd\u591f\u987a\u5229\u5730\u5b8c\u6210\u4e0a\u8ff0\u7684\u4eb2\u7535\u4ea4\u53c9\u5076\u8054\u8fc7\u7a0b\uff0c\u5e76\u83b7\u5f97\u76f8\u5e94\u7684\u4e0d\u5bf9\u79f0\u5076\u8054\u4ea7\u72693am–3aq (60-74% \u6536\u7387\uff0c85-98% ee)\u3002\u540c\u65f6\uff0c\u5bf9\u4e8e\u8fdc\u7aef\u5e26\u6709\u82b3\u57fa\u53d6\u4ee3\u7684\u70f7\u57fa\u4eb2\u7535\u5e95\u72692r\u540c\u6837\u80fd\u591f\u826f\u597d\u5730\u517c\u5bb9\uff0c\u5e76\u83b7\u5f97\u4e2d\u7b49\u7a0b\u5ea6\u7684\u53cd\u5e94\u6536\u7387\uff0c\u7136\u800c\uff0c\u7f3a\u4e4f\u826f\u597d\u7684\u5bf9\u6620\u9009\u62e9\u6027\u63a7\u5236\u3002\u6b64\u5916\uff0c\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u4f53\u7cfb\u5bf9\u4e8e\u96cc\u916e\u884d\u751f\u7684\u4eb2\u7535\u5e95\u72692s\uff0c\u540c\u6837\u80fd\u591f\u4ee5\u826f\u597d\u7684\u53cd\u5e94\u6536\u7387\u4e0e\u4f18\u826f\u7684\u7acb\u4f53\u9009\u62e9\u6027\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u5076\u8054\u4ea7\u72693as\u3002 \u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217\u5055\u4e8c\u6c1f\u70ef\u57fa\u5e95\u7269\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76 (Table 3)\u3002\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c\u4e00\u7cfb\u5217\u82ef\u73af\u4f4d\u7f6e\u5177\u6709\u4f9b\u7535\u5b50\u4ee5\u53ca\u5438\u7535\u5b50\u57fa\u56e2\u53d6\u4ee3\u7684\u5055\u4e8c\u6c1f\u70ef\u57fa\u5e95\u7269\uff0c\u5747\u80fd\u8f83\u597d\u5730\u4e0e\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u517c\u5bb9\uff0c\u5e76\u80fd\u591f\u4ee5\u9ad8\u5ea6\u7684\u7acb\u4f53\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u5076\u8054\u4ea7\u72693ba–3ia (59-80% \u6536\u7387, 88-91% ee)\u3002\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c\u5404\u7c7b\u5177\u6709\u6742\u73af\u57fa\u56e21j\u3001\u82c4\u57fa1k\u3001\u70f7\u57fa1l-n\u4ee5\u53ca\u916f\u57fa1o-1p\u53d6\u4ee3\u7684\u5055\u4e8c\u6c1f\u70ef\u57fa\u5e95\u7269\uff0c\u5747\u80fd\u591f\u83b7\u5f97\u826f\u597d\u7684\u53cd\u5e94\u6536\u7387\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u63a7\u5236\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u65e0\u5bfc\u5411\u57fa\u56e2\u5b58\u5728\u7684\u5055\u4e8c\u6c1f\u70ef\u57fa\u5e95\u72691q-1r\uff0c\u5219\u65e0\u6cd5\u83b7\u5f97\u9884\u671f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5076\u8054\u4ea7\u7269\u3002\u800c\u5bf9\u4e8e\u5177\u6709\u7fa7\u9178\u57fa\u56e2\u7684\u5e95\u72691s\uff0c\u5219\u4ec5\u80fd\u591f\u83b7\u5f97\u75d5\u91cf\u7684\u5076\u8054\u4ea7\u7269\uff0c\u8fdb\u800c\u8868\u660e\u5728\u5055\u4e8c\u6c1f\u70ef\u57fa\u5e95\u7269\u4e2d\uff0c\u916f\u57fa\u57fa\u56e2\u7684\u5b58\u5728\uff0c\u5bf9\u4e8e\u4e0a\u8ff0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u8fc7\u7a0b\u7684\u987a\u5229\u8fdb\u884c\u5c24\u4e3a\u5173\u952e\u3002   \u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c\u5728\u4e0a\u8ff0\u7684\u6807\u51c6\u6761\u4ef6\u4e0b\u8fdb\u884c\u76841a\u4e0e2a\u7684\u514b\u7ea7\u89c4\u6a21\u5b9e\u9a8c\uff0c\u540c\u6837\u80fd\u591f\u83b7\u5f97\u826f\u597d\u7684\u53cd\u5e94\u6536\u7387\u4e0e\u4f18\u826f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u63a7\u5236\u3002\u4e4b\u540e\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u901a\u8fc7\u4e0a\u8ff0\u5bf9\u6620\u9009\u62e9\u6027\u5076\u8054\u8fc7\u7a0b\u83b7\u5f97\u7684\u624b\u6027\u5076\u8054\u4ea7\u72693aa\u80fd\u591f\u8fdb\u4e00\u6b65\u5b8c\u6210\u591a\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u5408\u6210\u8f6c\u5316\u8fc7\u7a0b (Scheme 1)\u3002 \u63a5\u4e0b\u6765\uff0c\u4e3a\u63d0\u51fa\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406\uff0c\u4f5c\u8005\u8fdb\u884c\u4e00\u7cfb\u5217\u76f8\u5173\u7684\u5b9e\u9a8c\u7814\u7a76 (Scheme 2)\u3002\u9996\u5148\uff0c\u8be5\u5c0f\u7ec4\u57281a\u4e0e2a\u7684\u6807\u51c6\u53cd\u5e94\u4f53\u7cfb\u4e2d\uff0c\u52a0\u5165\u81ea\u7531\u57fa\u6291\u5236\u5242TEMPO\u4ee5\u53caBHT\u65f6\uff0c\u89c2\u5bdf\u5230\u76f8\u5e94\u7684\u5076\u8054\u8fc7\u7a0b\u53d7\u5230\u5b8c\u5168\u6291\u5236\uff0c\u8fdb\u800c\u8868\u660e\u4e0a\u8ff0\u7684\u4e0d\u5bf9\u79f0\u5076\u8054\u8fc7\u7a0b\u4e2d\u6d89\u53ca\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53\u7684\u53c2\u4e0e (Scheme 2a)\u3002\u4e4b\u540e\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u5728\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c1a\u4e0e\u787c\u9178\u916f9\u4e4b\u95f4\u7684\u53cd\u5e94\u8fc7\u7a0b\u65e0\u6cd5\u83b7\u5f97\u9884\u671f\u7684\u5076\u8054\u4ea7\u72693aa (Scheme 2b)\uff1b\u800c\u4e14\uff0c\u901a\u8fc7\u787c\u9178\u916f10\u4e0e2a\u4e4b\u95f4\u7684\u53cd\u5e94\uff0c\u540c\u6837\u65e0\u6cd5\u83b7\u5f97\u9884\u671f\u7684\u5076\u8054\u4ea7\u726911 (Scheme 2c)\u3002\u901a\u8fc7\u8fd9\u4e00\u5b9e\u9a8c\u89c2\u5bdf\uff0c\u80fd\u591f\u6392\u9664\u901a\u8fc7\u539f\u4f4d\u5f62\u6210\u7684\u787c\u5316\u4ea7\u7269\u8fdb\u884c\u540e\u7eedSuzuki\u5076\u8054\u7684\u673a\u7406\u8def\u5f84\u3002\u63a5\u4e0b\u6765\uff0c\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c\u9009\u62e9\u624b\u6027\u82c4\u57fa\u6c2f\u5e95\u7269R–2a\u65f6\uff0c\u5728\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u4f53\u7cfb\u4e2d\uff0c\u5219\u4ec5\u80fd\u591f\u83b7\u5f97\u5177\u6709\u6781\u4f4eee %\u7684\u5076\u8054\u4ea7\u72693aa (Scheme 2d)\u3002\u8fd9\u4e00\u4e8b\u5b9e\u8868\u660e\uff0c\u4e0a\u8ff0\u7684\u4e0d\u5bf9\u79f0\u5076\u8054\u8fc7\u7a0b\u4e2d\u6d89\u53ca\u901a\u8fc7\u82c4\u57fa\u6c2f\u7684SET\u8fc7\u7a0b\uff0c\u5f62\u6210\u7684\u82c4\u57fa\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53\u7684\u53c2\u4e0e\u3002   \u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\u3001\u524d\u671f\u5bf9\u4e8eNaI\u5728\u5076\u8054\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u7684\u5e94\u7528\u7814\u7a76[12]-[13]\u4ee5\u53ca\u954d\u914d\u5408\u7269A\u5206\u79bb (Figure 2)\u7684\u76f8\u5173\u6587\u732e\u62a5\u9053[12]\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406\u8def\u5f84 (Figure 3)\u3002 \u603b\u7ed3\uff1a\u5357\u4eac\u5927\u5b66\u7684\u53f2\u58ee\u5fd7\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u901a\u8fc7\u954d\u50ac\u5316\u5242\u53c2\u4e0e\u7684\u5916\u6d88\u65cb\u82c4\u57fa\u4eb2\u7535\u5e95\u7269\u4e0e\u5055\u4e8c\u6c1f\u70ef\u57fa\u5316\u5408\u7269\u4e4b\u95f4\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4eb2\u7535\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u7b56\u7565\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u70ef\u4e19\u57fa\u7acb\u4f53\u751f\u6210\u4e2d\u5fc3\u7684\u5355\u6c1f\u70ef\u57fa\u884d\u751f\u7269\u7684\u6784\u5efa\u3002\u540c\u65f6\uff0c\u7814\u7a76\u8868\u660e\uff0c\u53cd\u5e94\u673a\u7406\u4e3b\u8981\u6d89\u53ca\u87af\u5408\u8f85\u52a9\u7684C-F\u952e\u6d3b\u5316\u8fc7\u7a0b\u3002 \u53c2\u8003\u6587\u732e\uff1a [1] C. Ni, M. Hu, J. Hu, Chem. Rev. 2015, 115, 765. doi: 10.1021\/cr5002386. [2] H. Amii, K. Uneyama, Chem. Rev. 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