{"id":41302,"date":"2022-03-03T08:00:21","date_gmt":"2022-03-03T00:00:21","guid":{"rendered":"\/\/www.gsbet888.com\/?p=41302"},"modified":"2022-03-08T18:19:20","modified_gmt":"2022-03-08T10:19:20","slug":"jp%e7%a0%94%e7%a9%b6%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%955%ef%bc%9acell-pump%e5%9e%8bchrmine%e8%9b%8b%e7%99%bd%e7%9a%84%e4%b8%89%e7%bb%b4%e7%bb%93%e6%9e%84%e8%a7%a3%e6%9e%90","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/jp%e7%a0%94%e7%a9%b6%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%95\/2022\/03\/jp%e7%a0%94%e7%a9%b6%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%955%ef%bc%9acell-pump%e5%9e%8bchrmine%e8%9b%8b%e7%99%bd%e7%9a%84%e4%b8%89%e7%bb%b4%e7%bb%93%e6%9e%84%e8%a7%a3%e6%9e%90.html","title":{"rendered":"JP\u7814\u7a76\u6700\u65b0\u8fdb\u5c555\uff1aCell | Pump\u578bChRmine\u86cb\u767d\u7684\u4e09\u7ef4\u7ed3\u6784\u89e3\u6790"},"content":{"rendered":"<p><span lang=\"EN-US\">2022<\/span>\u5e74<span lang=\"EN-US\">2<\/span>\u6708<span lang=\"EN-US\">2<\/span>\u65e5\uff0c\u4e1c\u4eac\u5927\u5b66\u52a0\u85e4\u82f1\u660e\uff08<span lang=\"EN-US\">Hideaki E. Kato<\/span>\uff09\u526f\u6559\u6388\u8bfe\u9898\u7ec4\u5728\u4e13\u4e1a\u6742\u5fd7<em><b><span lang=\"EN-US\">Cell<\/span><\/b><\/em>\u4e0a\u5728\u7ebf\u53d1\u8868\u4e86\u9898\u4e3a<span lang=\"EN-US\">\u00a0<\/span>\u300c<span lang=\"EN-US\">Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine<\/span>\u300d\u7684\u79d1\u6280\u8bba\u6587\uff0c\u8be5\u7814\u7a76\u786e\u5b9a\u4e86<span lang=\"EN-US\">ChRmine<\/span>\u7684\u4e09\u7ef4\u7ed3\u6784\uff0c\u5e76\u4e14\u6210\u529f\u5730\u5f00\u53d1\u51fa\u4e09\u79cd<span lang=\"EN-US\">ChRmine<\/span>\u53d8\u5f02\u4f53\u5e94\u7528\u4e8e\u5148\u8fdb\u7684\u5149\u9057\u4f20\u5b66\u5b9e\u9a8c\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/2-17.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41297 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/2-17-680x246.png\" alt=\"\" width=\"680\" height=\"246\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/2-17-680x246.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/2-17-300x108.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/2-17.png 747w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p><span lang=\"EN-US\"><a href=\"https:\/\/doi.org\/10.1016\/j.cell.2022.01.007\" target=\"_blank\" rel=\"noopener noreferrer\"><i>https:\/\/doi.org\/10.1016\/j.cell.2022.01.007<\/i><\/a><\/span><i><\/i><\/p>\n<p><i><u><span lang=\"EN-US\">\u00a0<\/span><\/u><\/i><\/p>\n<h4 style=\"text-align: center;\" align=\"center\"><span lang=\"EN-US\">01<\/span><\/h4>\n<h4 style=\"text-align: center;\" align=\"center\"><span lang=\"EN-US\">\u2014<\/span><\/h4>\n<h4 style=\"text-align: center;\" align=\"center\">\u7814\u7a76\u4eae\u70b9<\/h4>\n<p align=\"center\"><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p><span lang=\"EN-US\">1. ChRmine<\/span>\u662f\u4e00\u79cd\u901a\u8fc7\u5149\u523a\u6fc0\u8f6c\u8fd0\u9633\u79bb\u5b50\u7684\u86cb\u767d\u8d28\uff0c\u8fd1\u5e74\u6765\u5907\u53d7\u5173\u6ce8\uff0c\u5229\u7528\u51b7\u51bb\u7535\u955c\u786e\u5b9a\u4e86<span lang=\"EN-US\">ChRmine<\/span>\u7684\u4e09\u7ef4\u7ed3\u6784\uff0c\u9610\u660e\u4e86<span lang=\"EN-US\">ChRmine<\/span>\u4f5c\u4e3a\u79bb\u5b50\u901a\u9053\u53d1\u6325\u4f5c\u7528\u7684\u673a\u5236\u3002<\/p>\n<p><span lang=\"EN-US\">2. <\/span>\u5229\u7528\u83b7\u5f97\u7684\u4e09\u7ef4\u7ed3\u6784\u77e5\u8bc6\uff0c\u521b\u5efa\u4e86\u4e00\u79cd\u81ea\u7136\u754c\u4e2d\u4e0d\u5b58\u5728\u7684<span lang=\"EN-US\">ChRmine<\/span>\uff0c\u5e76\u5c06\u5176\u7528\u4f5c\u5206\u5b50\u5de5\u5177\uff0c\u4ee5\u5b9e\u73b0\u66f4\u5148\u8fdb\u7684\u5149\u9057\u4f20\u5b66\u5b9e\u9a8c\u3002<\/p>\n<p><span lang=\"EN-US\">3. <\/span>\u8be5\u7814\u7a76\u5c06\u52a0\u6df1\u5bf9\u901a\u9053\u89c6\u7d2b\u7ea2\u8d28\u79bb\u5b50\u8f6c\u8fd0\u673a\u5236\u591a\u6837\u6027\u7684\u8ba4\u8bc6\uff0c\u9884\u8ba1\u5f00\u53d1\u7684\u4fee\u9970<span lang=\"EN-US\">ChRmine<\/span>\u5c06\u901a\u8fc7\u5149\u9057\u4f20\u5b66\u4e3a\u795e\u7ecf\u79d1\u5b66\u548c\u533b\u5b66\u7684\u53d1\u5c55\u505a\u51fa\u8d21\u732e\u3002<\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<h4 style=\"text-align: center;\" align=\"center\"><span lang=\"EN-US\">02<\/span><\/h4>\n<h4 style=\"text-align: center;\" align=\"center\"><span lang=\"EN-US\">\u2014<\/span><\/h4>\n<h4 style=\"text-align: center;\" align=\"center\">\u7814\u7a76\u6982\u8981<\/h4>\n<p align=\"center\"><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p>\u3010\u80cc\u666f\u3011<\/p>\n<p>\u8bb8\u591a\u751f\u7269\uff0c\u4ece\u4eba\u7c7b\u5230\u5fae\u751f\u7269\uff0c\u901a\u8fc7\u611f\u5149\u86cb\u767d\u63a5\u6536\u5149\uff0c\u5e76\u4ece\u5b83\u4eec\u90a3\u91cc\u63a5\u6536\u4fe1\u606f\u548c\u80fd\u91cf\u3002\u5728\u611f\u5149\u86cb\u767d\u4e2d\uff0c\u201c\u79bb\u5b50\u8f6c\u8fd0\u89c6\u7d2b\u7ea2\u8d28\u201d\u4f5c\u4e3a\u5fae\u751f\u7269\u7684\u79bb\u5b50\u6cf5\u548c\u79bb\u5b50\u901a\u9053\uff0c\u662f\u4e00\u79cd\u7cbe\u7ec6\u7684\u5206\u5b50\u88c5\u7f6e\uff0c\u53ef\u5c06\u5149\u80fd\u8f6c\u5316\u4e3a\u79bb\u5b50\u8fd0\u8f93\u3002\u8fd9\u4e00\u7279\u6027\u5f15\u8d77\u4e86\u4eba\u4eec\u7684\u6ce8\u610f\uff0c\u79bb\u5b50\u8f6c\u8fd0\u89c6\u7d2b\u7ea2\u8d28\u5df2\u6210\u4e3a\u4e00\u79cd\u53ef\u4ee5\u901a\u8fc7\u5149\u63a7\u5236\u7279\u5b9a\u795e\u7ecf\u7ec6\u80de\u6d3b\u52a8\u7684\u5b9e\u9a8c\u5de5\u5177\uff0c\u5e76\u5df2\u6210\u4e3a\u795e\u7ecf\u79d1\u5b66\u4e2d\u5fc5\u4e0d\u53ef\u5c11\u7684\u6280\u672f\uff08\u5149\u9057\u4f20\u5b66\uff09\u3002\u7136\u800c\uff0c\u4f5c\u4e3a\u5149\u9057\u4f20\u5b66\u5de5\u5177\u4f7f\u7528\u7684\u901a\u9053\u89c6\u7d2b\u7ea2\u8d28\u5b58\u5728\u5149\u7535\u6d41\u5f31\u3001\u5149\u654f\u6027\u4f4e\u3001\u53ea\u80fd\u901a\u8fc7\u77ed\u6ce2\u957f\u5149\u6fc0\u6d3b\u7b49\u95ee\u9898\u3002<span lang=\"EN-US\">ChRmine<\/span>\u662f\u8fd1\u5e74\u6765\u5728\u81ea\u7136\u754c\u4e2d\u53d1\u73b0\u7684\u4e00\u79cd\u901a\u9053\u89c6\u7d2b\u7ea2\u8d28\uff0c\u4f5c\u4e3a\u4e00\u79cd\u5149\u9057\u4f20\u5b66\u5de5\u5177\u5177\u6709\u6781\u5176\u5f3a\u5927\u7684\u6027\u80fd\uff0c\u80fd\u88ab\u9ad8\u79bb\u5b50\u7535\u6d41\u3001\u9ad8\u5149\u654f\u6027\u548c\u957f\u6ce2\u957f\u5149\u6fc0\u6d3b\u3002\u6b64\u5916\uff0c\u57fa\u4e8e\u6c28\u57fa\u9178\u5e8f\u5217\u7684\u7cfb\u7edf\u53d1\u80b2\u5206\u6790\u8868\u660e\uff0c\u867d\u7136\u529f\u80fd\u662f\u901a\u9053\u578b\u89c6\u7d2b\u7ea2\u8d28\uff0c\u4f46\u6c28\u57fa\u9178\u5e8f\u5217\u5177\u6709\u7c7b\u4f3c\u4e8e<span lang=\"EN-US\">Pump<\/span>\u578b\u89c6\u7d2b\u7ea2\u8d28\u7684\u6709\u8da3\u7279\u5f81\u3002\u7136\u800c\uff0c<span lang=\"EN-US\">\u201cChRmine <\/span>\u548c<span lang=\"EN-US\">Pump<\/span>\u578b\u89c6\u7d2b\u7ea2\u8d28\u6709\u591a\u76f8\u4f3c\uff1f\u201d\uff0c\u201c\u5982\u679c\u662f\uff0c\u4e3a\u4ec0\u4e48<span lang=\"EN-US\">ChRmine<\/span>\u53ef\u4ee5\u5145\u5f53\u79bb\u5b50\u901a\u9053\uff1f\u201d\uff0c\u4ee5\u53ca\u201c\u6211\u4eec\u80fd\u5426\u5c06<span lang=\"EN-US\">ChRmine<\/span>\u6539\u9020\u4e3a\u5149\u9057\u4f20\u5b66\u5de5\u5177\uff1f\u201d\u7b49\u4e00\u7cfb\u5217\u672a\u77e5\u70b9\u5f15\u8d77\u4e86\u5927\u5bb6\u7684\u5e7f\u6cdb\u5174\u8da3\u3002<\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p>\u3010\u7ed3\u679c\u4e0e\u8ba8\u8bba\u3011<\/p>\n<p>\u672c\u6587\u4e2d\uff0c\u7814\u7a76\u5c0f\u7ec4\u4f7f\u7528\u51b7\u51bb\u7535\u5b50\u663e\u5fae\u955c\u4ee5<span lang=\"EN-US\"> 2.0 \u00c5 <\/span>\u7684\u6781\u9ad8\u5206\u8fa8\u7387\u6210\u529f\u5730\u786e\u5b9a\u4e86<span lang=\"EN-US\"> ChRmine <\/span>\u7684\u4e09\u7ef4\u7ed3\u6784\u3002\u7ed3\u679c\u53d1\u73b0\uff1a<span lang=\"EN-US\">ChRmine <\/span>\u5f62\u6210\u4e09\u805a\u4f53\uff0c\u4e0e\u5f62\u6210\u4e8c\u805a\u4f53\u7684\u5e38\u89c4\u901a\u9053\u89c6\u7d2b\u7ea2\u8d28\u76f8\u6bd4\uff0c\u5b83\u66f4\u7c7b\u4f3c\u4e8e\u5f62\u6210\u4e09\u805a\u4f53\u7684<span lang=\"EN-US\">Pump<\/span>\u578b\uff08\u56fe<span lang=\"EN-US\"> 1<\/span>\uff09\u3002 \u5bf9\u5355\u4f53\u7ed3\u6784\u7684\u8fdb\u4e00\u6b65\u6bd4\u8f83\u8868\u660e\uff0c<span lang=\"EN-US\">ChRmine <\/span>\u4e0e<span lang=\"EN-US\">Pump<\/span>\u578b\u89c6\u7d2b\u7ea2\u8d28\u66f4\u76f8\u4f3c\uff0c\u800c\u4e0d\u662f\u4f20\u7edf\u7684\u4e8c\u805a\u4f53\u901a\u9053\u89c6\u7d2b\u7ea2\u8d28\uff08\u56fe<span lang=\"EN-US\"> 2<\/span>\uff09\u3002\u90a3\u4e48\uff0c\u4e3a\u4e86\u56de\u7b54 \u201c\u4e3a\u4ec0\u4e48<span lang=\"EN-US\">ChRmine<\/span>\u53ef\u4ee5\u4f5c\u4e3a\u79bb\u5b50\u901a\u9053\u540c\u65f6\u5177\u6709\u7c7b\u4f3c\u4e8e<span lang=\"EN-US\">Pump<\/span>\u578b\u7684\u7ed3\u6784\uff1f\u201d\u8fd9\u4e2a\u95ee\u9898\uff0c\u7814\u7a76\u4eba\u5458\u4ed4\u7ec6\u89c2\u5bdf\u4e86\u5355\u4f53\u7684\u7ed3\u6784\u3002<span lang=\"EN-US\"> ChRmine <\/span>\u4e0e<span lang=\"EN-US\">Pump<\/span>\u578b\u89c6\u7d2b\u7ea2\u8d28\u76f8\u6bd4\u5177\u6709\u4ee5\u4e0b\u7279\u5f81\uff1a\uff08<span lang=\"EN-US\">1<\/span>\uff09\u7b2c\u4e8c\u4e2a\u8de8\u819c\u87ba\u65cb\u5728\u7ec6\u80de\u5185\u5916\u5411\u5916\u584c\u9677\uff0c\uff08<span lang=\"EN-US\">2<\/span>\uff09\u7b2c\u4e09\u4e2a\u8de8\u819c\u87ba\u65cb\u5728\u819c\u4e2d\u95f4\u5c55\u5f00\u3002\uff08<span lang=\"EN-US\">3<\/span>\uff09\u7b2c\u4e00\u4e2a\u7ec6\u80de\u5916\u73af\u957f\u800c\u873f\u8712\u3002\u7ed3\u679c\u53d1\u73b0\uff1a<b><span lang=\"EN-US\">ChRmine<\/span><\/b><b>\u5728<\/b><b>\u7ec6<\/b><b>\u80de\u5185\u5916\u5177\u6709<\/b><b>\u8f83<\/b><b>\u5927\u7684\u79bb\u5b50\u6e17\u900f\u7a7a\u9699<\/b>\uff08\u56fe<span lang=\"EN-US\">2<\/span>\uff09\u3002\u9010\u4e2a\u4f20\u8f93\u79bb\u5b50\u7684<span lang=\"EN-US\">Pump<\/span>\u578b\u5728\u5355\u4f53\u4e2d\u6ca1\u6709\u7a7a\u9699\uff0c\u800c\u8fc4\u4eca\u4e3a\u6b62\u7ed3\u6784\u5df2\u7ecf\u9610\u660e\u7684\u901a\u9053\u89c6\u7d2b\u7ea2\u8d28\u5728\u5355\u4f53\u4e2d\u5177\u6709\u4f5c\u4e3a\u79bb\u5b50\u4f20\u8f93\u8def\u5f84\u7684\u7a7a\u9699\uff0c\u53d1\u6325\u6e20\u9053\u7684\u4f5c\u7528\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/3-18.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41298 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/3-18-680x567.png\" alt=\"\" width=\"680\" height=\"567\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/3-18-680x567.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/3-18-300x250.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/3-18.png 737w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/4-18.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41299 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/4-18-680x404.png\" alt=\"\" width=\"680\" height=\"404\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/4-18-680x404.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/4-18-300x178.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/4-18.png 725w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>\u968f\u540e\uff0c\u5229\u7528\u4ece\u7ed3\u6784\u4e2d\u83b7\u5f97\u7684\u77e5\u8bc6\uff0c\u4e3a\u4e86\u521b\u9020\u4e00\u79cd\u6539\u8fdb<span lang=\"EN-US\">ChRmine<\/span>\u7279\u6027\u7684\u5149\u9057\u4f20\u5b66\u5de5\u5177\uff0c<span lang=\"EN-US\">ChRmine<\/span>\u80fd\u88ab\u957f\u6ce2\u957f\u5149\u6fc0\u6d3b\u8fd9\u4e00\u7279\u5f81\u88ab\u5229\u7528\u3002\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u4fee\u9970\u5438\u6536\u5149\u7684\u4f4d\u70b9\u5468\u56f4\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\uff0c\u6210\u529f\u751f\u4ea7\u51fa<span lang=\"EN-US\">ChRmine<\/span>\u7684\u4e09\u79cd\u53d8\u5f02\u4f53\uff1a<span lang=\"EN-US\">rsChRmine<\/span>\u3001<span lang=\"EN-US\">hsChRmine<\/span>\u3001<span lang=\"EN-US\">frChRmine<\/span>\uff08\u5907\u6ce8\uff1a\u8fd9\u4e09\u79cd\u53d8\u5f02\u4f53\u7684\u5438\u6536\u6ce2\u957f\u4e0d\u4e00\u6837\uff09\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u4f7f\u7528\u8fd9\u4e9b<span lang=\"EN-US\">ChRmine<\/span>\u53d8\u5f02\u4f53\uff0c\u8fdb\u884c\u4e86\u201c\u4e09\u8272\u5149\u9057\u4f20\u5b66\u5b9e\u9a8c\u201d\uff0c\u9996\u6b21\u5b9e\u73b0\u4f7f\u7528\u4e09\u79cd\u989c\u8272\uff08\u84dd\u8272\u3001\u9ec4\u8272\u548c\u7eff\u8272\uff09\u7684\u5149\u5728\u6d3b\u4f53\u5c0f\u9f20\u5927\u8111\u4e2d\u540c\u65f6\u64cd\u7eb5\u548c\u6d4b\u91cf\u591a\u4e2a\u795e\u7ecf\u7ec6\u80de\u7fa4\u3002\u6700\u540e\uff0c\u7814\u7a76\u4eba\u5458\u8bc1\u660e<span lang=\"EN-US\"> rsChRmine <\/span>\u662f\u7b2c\u4e00\u4e2a\u5373\u4f7f\u5728\u8fd1\u7ea2\u5916\u5149\uff08<span lang=\"EN-US\">&gt; 740 nm<\/span>\uff09\u4e0b\u4e5f\u80fd\u88ab\u6fc0\u6d3b\u7684\u901a\u9053\u89c6\u7d2b\u7ea2\u8d28\uff0c\u8bc1\u660e\u4e86<span lang=\"EN-US\"> rsChRmine <\/span>\u7684\u51fa\u8272\u6027\u80fd\uff08\u56fe 3\uff09\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/5-18.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41300 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/5-18.png\" alt=\"\" width=\"572\" height=\"506\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/5-18.png 572w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/5-18-300x265.png 300w\" sizes=\"(max-width: 572px) 100vw, 572px\" \/><\/a><\/p>\n<p>\u3010\u5c55\u671b\u3011<\/p>\n<p>\u672a\u6765\u53d1\u5c55 \u672c\u7814\u7a76\u9996\u6b21\u9610\u660e\u4e86\u201c\u63a5\u8fd1<span lang=\"EN-US\">Pump<\/span>\u578b\u7684\u65b0\u578b\u901a\u9053\u89c6\u7d2b\u7ea2\u8d28\u201d<span lang=\"EN-US\">ChRmine<\/span>\u7684\u4e09\u7ef4\u7ed3\u6784\u3002\u8fd9\u4e9b\u7ed3\u679c\u4e0d\u4ec5\u6709\u52a9\u4e8e\u4e86\u89e3\u5404\u79cd\u901a\u9053\u89c6\u7d2b\u7ea2\u8d28\u7684\u79bb\u5b50\u6e17\u900f\u673a\u5236\uff0c\u800c\u4e14\u62d3\u5bbd\u4e86\u901a\u9053\u89c6\u7d2b\u7ea2\u8d28\u7684\u7ed3\u6784\u5206\u6790\u65b9\u6cd5\u8303\u56f4\uff0c\u4e3a\u9610\u660e\u89c6\u7d2b\u7ea2\u8d28\u7684\u5206\u5b50\u673a\u7406\u8fdb\u5316\u63d0\u4f9b\u4e86\u65b0\u7684\u7ebf\u7d22\u3002\u6b64\u5916\uff0c\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u5229\u7528\u83b7\u5f97\u7684\u7ed3\u6784\u4fe1\u606f\uff0c\u7814\u7a76\u4eba\u5458\u521b\u5efa\u4e86\u4e09\u79cd\u53d8\u4f53\uff08<span lang=\"EN-US\">rsChRmine<\/span>\u3001<span lang=\"EN-US\">hsChRmine<\/span>\u3001<span lang=\"EN-US\">frChRmine<\/span>\uff09\uff0c\u8fdb\u4e00\u6b65\u53d1\u6325\u4e86<span lang=\"EN-US\"> ChRmine <\/span>\u7684\u51fa\u8272\u6027\u80fd\uff0c\u7279\u522b\u662f\u4f7f\u7528<span lang=\"EN-US\"> rsChRmine <\/span>\u521b\u9020\u4e86\u65b0\u7684\u5149\u9057\u4f20\u5b9e\u9a8c\u3002\u9884\u8ba1\u8fd9\u4e9b<span lang=\"EN-US\">ChRmine <\/span>\u53d8\u4f53\u4e0d\u4ec5\u5c06\u4fc3\u8fdb\u795e\u7ecf\u79d1\u5b66\u7814\u7a76\uff0c\u8fd8\u5c06\u7528\u4e8e\u773c\u75b2\u52b3\u75be\u75c5\u7684\u57fa\u56e0\u6cbb\u7597\u5e94\u7528\u3002<\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p>\u672c\u7814\u7a76\u7531\u4e1c\u4eac\u5927\u5b66\uff0c\u4eac\u90fd\u5927\u5b66\u548c\u65af\u5766\u798f\u5927\u5b66\u7b49\u591a\u5bb6\u5355\u4f4d\u5408\u4f5c\u5b8c\u6210\uff1b\u7b2c\u4e00\u4f5c\u8005\u4e3a<span lang=\"EN-US\">Koichiro E. Kishi<\/span>\u535a\u58eb\uff0c\u901a\u8baf\u4f5c\u8005\u4e3a\u52a0\u85e4\u82f1\u660e\uff08<span lang=\"EN-US\">Hideaki E. Kato<\/span>\uff09\u526f\u6559\u6388\u3002\u672c\u6587\u53d7\u5230\u300c<span lang=\"EN-US\">JST <\/span>\u5275\u767a\u7684\u7814\u7a76\u652f\u63f4\u4e8b\u696d\uff08\u8ab2\u984c\u756a\u53f7\uff1a<span lang=\"EN-US\">JPMJFR204S<\/span>\uff09\u300d\u3001\u300c<span lang=\"EN-US\">JST CREST <\/span>\uff08\u8ab2\u984c\u756a\u53f7\uff1a<span lang=\"EN-US\">JPMJCR21P3<\/span>\uff09\u300d\u3001\u300c<span lang=\"EN-US\">JST <\/span><span lang=\"JA\">\u3055\u304d\u304c\u3051<\/span>\uff08\u8ab2\u984c\u756a\u53f7\uff1a<span lang=\"EN-US\">JPMJPR1782<\/span>\u3001<span lang=\"EN-US\">JPMJPR1888<\/span>\uff09\u300d \u300c<span lang=\"EN-US\">AMED-BINDS <\/span>\uff08\u8ab2\u984c\u756a\u53f7\uff1a<span lang=\"EN-US\">JP18am0101079<\/span>\uff09\u300d\u300c\u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d\uff08\u8ab2\u984c\u756a\u53f7\uff1a<span lang=\"EN-US\"> JP20K21383<\/span>\u3001<span lang=\"EN-US\">JP21H01875<\/span>\uff09\u300d\u7684\u7ecf\u8d39\u652f\u6301\u3002<\/p>\n<p align=\"center\"><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p align=\"center\"><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<h4 style=\"text-align: center;\" align=\"center\"><span lang=\"EN-US\">03<\/span><\/h4>\n<h4 style=\"text-align: center;\" align=\"center\"><span lang=\"EN-US\">\u2014<\/span><\/h4>\n<h4 style=\"text-align: center;\" align=\"center\">\u4f5c\u8005\u4ecb\u7ecd<\/h4>\n<p style=\"text-align: left;\" align=\"center\"><span lang=\"EN-US\">\u00a0<\/span>\u52a0\u85e4\u82f1\u660e\uff08<span lang=\"EN-US\">Hideaki E. Kato<\/span>\uff09\u3002\u4e1c\u4eac\u5927\u5b66\u7406\u5b66\u7814\u7a76\u79d1\u548c\u751f\u7269\u5b66\u4e13\u4e1a\u526f\u6559\u6388\uff08<span lang=\"EN-US\">PI<\/span>\uff09\u3002<span lang=\"EN-US\">Kato<\/span>\u6559\u6388\u81f4\u529b\u4e8e\u86cb\u767d\u8d28\u7ed3\u6784\u751f\u7269\u5b66\u7684\u57fa\u7840\u7814\u7a76\uff0c\u662f\u86cb\u767d\u8d28\u5de5\u5b66\u548c\u86cb\u767d\u8d28\u901a\u9053\u7814\u7a76\u9886\u57df\u7684\u9752\u5e74\u5b66\u8005\u3002\u66fe\u83b7<span lang=\"EN-US\">2013<\/span>\u5e74\u65e5\u672c\u5b66\u672f\u632f\u5174\u4f1a\u80b2\u5fd7\u5956\uff0c<span lang=\"EN-US\">2014<\/span>\u5e74\u4e1c\u4eac\u5927\u5b66\u603b\u957f\u5956\uff0c<span lang=\"EN-US\">2020<\/span>\u5e74\u6587\u90e8\u79d1\u5b66\u5927\u81e3\u79d1\u5b66\u8005\u5956\u7b49\u91cd\u5927\u5956\u9879\uff1b\u5728<b><i><span lang=\"EN-US\">Nature<\/span><strong>\uff0c<span lang=\"EN-US\">Science<\/span>\uff0c<span lang=\"EN-US\">Cell<\/span>\uff0c<span lang=\"EN-US\">PNAS<\/span><\/strong><\/i><\/b>\u7b49\u56fd\u9645\u77e5\u540d\u79d1\u5b66\u6742\u5fd7\u53d1\u8868\u7814\u7a76\u578b\u8bba\u6587<span lang=\"EN-US\">30<\/span>\u4f59\u7bc7\u3002\u5176\u7814\u7a76\u6210\u679c\u88ab\u5f15\u7528<span lang=\"EN-US\">3200<\/span>\u4f59\u6b21\uff0c\u5176\u4e2d\u5355\u7bc7\u6700\u9ad8\u5f15\u7528\u6570\u8fbe<span lang=\"EN-US\">670<\/span>\u4f59\u6b21\uff0c<span lang=\"EN-US\">h<\/span>\u6307\u6570\u4e3a<span lang=\"EN-US\">22 (2022\/02\/20\/, Google Scholar)<\/span>\u3002<\/p>\n<p align=\"center\"><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/6-15.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41301 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/6-15.png\" alt=\"\" width=\"295\" height=\"295\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/6-15.png 295w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/6-15-150x150.png 150w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/6-15-120x120.png 120w\" sizes=\"(max-width: 295px) 100vw, 295px\" \/><\/a><\/p>\n<p align=\"center\">&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;\u534e\u4e3d\u5206\u5272\u7ebf&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/7-10.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41280 size-medium\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/7-10-300x300.png\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/7-10-300x300.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/7-10-150x150.png 150w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/7-10-120x120.png 120w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/02\/7-10.png 406w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u5173\u6ce8\u5316\u5b66\u7a7a\u95f4\uff0c\u8ffd\u8e2a\u524d\u6cbf\u65b9\u5411\uff01<\/p>\n<p>&nbsp;<\/p>\n<p><u>\u6587\u7ae0\u6295\u7a3f\u548c\u5408\u4f5c<\/u><u>\u8bf7\u8054<\/u><u>\u7cfb\u5fae\u4fe1<\/u><u> ylyl5200<\/u><\/p>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/p>\n","protected":false},"excerpt":{"rendered":"2022\u5e742\u67082\u65e5\uff0c\u4e1c\u4eac\u5927\u5b66\u52a0\u85e4\u82f1\u660e\uff08Hideaki E. Kato\uff09\u526f\u6559\u6388\u8bfe\u9898\u7ec4\u5728\u4e13\u4e1a\u6742\u5fd7Cell\u4e0a\u5728\u7ebf\u53d1\u8868\u4e86\u9898\u4e3a\u00a0\u300cStructural basis for channel conduction in the pump-like channelrhodopsin ChRmine\u300d\u7684\u79d1\u6280\u8bba\u6587\uff0c\u8be5\u7814\u7a76\u786e\u5b9a\u4e86ChRmine\u7684\u4e09\u7ef4\u7ed3\u6784\uff0c\u5e76\u4e14\u6210\u529f\u5730\u5f00\u53d1\u51fa\u4e09\u79cdChRmine\u53d8\u5f02\u4f53\u5e94\u7528\u4e8e\u5148\u8fdb\u7684\u5149\u9057\u4f20\u5b66\u5b9e\u9a8c\u3002 https:\/\/doi.org\/10.1016\/j.cell.2022.01.007 \u00a0 01 \u2014 \u7814\u7a76\u4eae\u70b9 \u00a0 1. ChRmine\u662f\u4e00\u79cd\u901a\u8fc7\u5149\u523a\u6fc0\u8f6c\u8fd0\u9633\u79bb\u5b50\u7684\u86cb\u767d\u8d28\uff0c\u8fd1\u5e74\u6765\u5907\u53d7\u5173\u6ce8\uff0c\u5229\u7528\u51b7\u51bb\u7535\u955c\u786e\u5b9a\u4e86ChRmine\u7684\u4e09\u7ef4\u7ed3\u6784\uff0c\u9610\u660e\u4e86ChRmine\u4f5c\u4e3a\u79bb\u5b50\u901a\u9053\u53d1\u6325\u4f5c\u7528\u7684\u673a\u5236\u3002 2. \u5229\u7528\u83b7\u5f97\u7684\u4e09\u7ef4\u7ed3\u6784\u77e5\u8bc6\uff0c\u521b\u5efa\u4e86\u4e00\u79cd\u81ea\u7136\u754c\u4e2d\u4e0d\u5b58\u5728\u7684ChRmine\uff0c\u5e76\u5c06\u5176\u7528\u4f5c\u5206\u5b50\u5de5\u5177\uff0c\u4ee5\u5b9e\u73b0\u66f4\u5148\u8fdb\u7684\u5149\u9057\u4f20\u5b66\u5b9e\u9a8c\u3002 3. \u8be5\u7814\u7a76\u5c06\u52a0\u6df1\u5bf9\u901a\u9053\u89c6\u7d2b\u7ea2\u8d28\u79bb\u5b50\u8f6c\u8fd0\u673a\u5236\u591a\u6837\u6027\u7684\u8ba4\u8bc6\uff0c\u9884\u8ba1\u5f00\u53d1\u7684\u4fee\u9970ChRmine\u5c06\u901a\u8fc7\u5149\u9057\u4f20\u5b66\u4e3a\u795e\u7ecf\u79d1\u5b66\u548c\u533b\u5b66\u7684\u53d1\u5c55\u505a\u51fa\u8d21\u732e\u3002 \u00a0 02 \u2014 \u7814\u7a76\u6982\u8981 \u00a0 \u3010\u80cc\u666f\u3011 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