{"id":41492,"date":"2022-03-29T08:00:48","date_gmt":"2022-03-29T00:00:48","guid":{"rendered":"\/\/www.gsbet888.com\/?p=41492"},"modified":"2022-03-27T17:40:22","modified_gmt":"2022-03-27T09:40:22","slug":"%e6%b0%a8%e5%9f%ba%e6%9d%82%e7%8e%af%e5%88%86%e5%ad%90%e7%9a%84%e5%8e%bb%e6%b0%a8%e5%9f%ba%e6%b0%af%e5%8c%96%e6%96%b9%e6%b3%95%e5%ad%a6%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2022\/03\/%e6%b0%a8%e5%9f%ba%e6%9d%82%e7%8e%af%e5%88%86%e5%ad%90%e7%9a%84%e5%8e%bb%e6%b0%a8%e5%9f%ba%e6%b0%af%e5%8c%96%e6%96%b9%e6%b3%95%e5%ad%a6%e7%a0%94%e7%a9%b6.html","title":{"rendered":"\u6c28\u57fa\u6742\u73af\u5206\u5b50\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u65b9\u6cd5\u5b66\u7814\u7a76"},"content":{"rendered":"<p>\u672c\u6587\u4f5c\u8005:\u6749\u6749<\/p>\n<h4>\u5bfc\u8bfb<\/h4>\n<p>\u8fd1\u65e5\uff0c\u5fb7\u56fdMax-Planck Institut f\u00fcr Kohlenforschung\u7684J. Cornella\u7814\u7a76\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u5421\u5583\u9393\u76d0\u8bd5\u5242 (pyrylium reagent)\u4ee5\u53ca\u4e00\u7cfb\u5217\u4e0d\u540c\u7c7b\u578b\u7684\u6c2f\u8d1f\u79bb\u5b50\u6e90\u53c2\u4e0e\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u5408\u6210\u8f6c\u5316\u7b56\u7565\u5177\u6709\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\u3001\u5e7f\u6cdb\u7684\u5e95\u7269\u5e94\u7528\u8303\u56f4\u3001\u826f\u597d\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u5b9e\u9a8c\u64cd\u4f5c\u5b89\u5168\u6027\u7b49\u4f18\u52bf\u3002<\/p>\n<p>Deaminative chlorination of aminoheterocycles<\/p>\n<p>Ghiazza , T. Faber, A. G\u00f3mez-Palomino, J. Cornella, <em>Nat. Chem. <\/em><strong>2021<\/strong><em>, <\/em>ASAP. doi: <a href=\"https:\/\/doi.org\/10.1038\/s41557-021-00812-0\">10.1038\/s41557-021-00812-0<\/a>.<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/2-12.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41486 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/2-12.png\" alt=\"\" width=\"614\" height=\"152\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/2-12.png 614w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/2-12-300x74.png 300w\" sizes=\"(max-width: 614px) 100vw, 614px\" \/><\/a><\/p>\n<h4><strong>\u6b63\u6587<\/strong><\/h4>\n<p>\u76ee\u524d\uff0c\u8bbe\u8ba1\u4e00\u79cd\u80fd\u591f\u5728\u5404\u7c7b\u590d\u6742\u6709\u673a\u5206\u5b50\u4e2d\u9ad8\u6548\u5730\u5f15\u5165\u4e0e\u53bb\u9664\u4e00\u7cfb\u5217\u4e0d\u540c\u5b98\u80fd\u56e2\u7684\u5408\u6210\u8f6c\u5316\u7b56\u7565\uff0c\u4ecd\u9762\u4e34\u8bf8\u591a\u6311\u6218\u3002\u8fd9\u91cc\uff0c\u53d7\u5230\u901a\u8fc7\u53bb\u6c28\u9176 (deaminase)\u50ac\u5316\u7684\u9009\u62e9\u6027\u53bb\u6c28\u57fa\u5316\u8fc7\u7a0b (deaminative process, Fig. 1)<sup>[1]-[4]<\/sup>\u4ee5\u53ca\u7ecf\u5178\u7684Vilsmeier\u53cd\u5e94\u65b9\u6cd5\u5b66\u76f8\u5173\u7814\u7a76\u7684\u542f\u53d1\uff0cJ. Cornella\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u5421\u5583\u9393\u76d0\u8bd5\u5242 (pyrylium reagent)\u4ee5\u53ca\u4e00\u7cfb\u5217\u4e0d\u540c\u7c7b\u578b\u7684\u6c2f\u8d1f\u79bb\u5b50\u6e90\u53c2\u4e0e\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/3-12.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41487 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/3-12-680x561.png\" alt=\"\" width=\"680\" height=\"561\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/3-12-680x561.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/3-12-300x248.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/3-12.png 704w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>\u9996\u5148\uff0c\u4f5c\u8005\u9009\u62e9\u5641\u5511\u5316\u5408\u7269<strong>9<\/strong>\u4e0ePyry-BF<sub>4<\/sub>(<strong>1<\/strong>)\u539f\u4f4d\u5f62\u6210\u7684\u56db\u6c1f\u787c\u9178\u5421\u5576\u9393\u76d0<strong>10<\/strong>\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009\uff0c\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528HCl (\u53cd\u5e94\u6e29\u5ea6\u4e3a25 <sup>o<\/sup>C)\u3001MgCl<sub>2 <\/sub>(\u53cd\u5e94\u6e29\u5ea6\u4e3a80 <sup>o<\/sup>C)\u3001TMSCl (\u53cd\u5e94\u6e29\u5ea6\u4e3a50 <sup>o<\/sup>C)\u6216<em><sup>n<\/sup><\/em>Bu<sub>4<\/sub>NCl (\u53cd\u5e94\u6e29\u5ea6\u4e3a120 <sup>o<\/sup>C)\u4f5c\u4e3a\u6c2f\u8d1f\u79bb\u5b50\u6e90\uff0cMeCN\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u8fdb\u800c\u4ee5\u4f18\u826f\u7684\u53cd\u5e94\u6536\u7387\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u4ea7\u7269\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/4-12.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41488 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/4-12-680x431.png\" alt=\"\" width=\"680\" height=\"431\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/4-12-680x431.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/4-12-300x190.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/4-12.png 683w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>\u5728\u83b7\u5f97\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e4b\u540e\uff0c\u4f5c\u8005\u5f00\u59cb\u5bf9\u5404\u7c7b\u6c28\u57fa\u6742\u73af\u5e95\u7269\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u8003\u5bdf (Table 1)\u3002\u9996\u5148\uff0c\u7814\u7a76\u53d1\u73b0\uff0c\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u4f53\u7cfb\u5bf9\u4e8e\u4e00\u7cfb\u5217\u5177\u6709\u4e0d\u540c\u57fa\u56e2\u53d6\u4ee3\u76842-\u4ee5\u53ca4-\u6c28\u57fa\u5421\u5576\u5e95\u7269\uff0c\u5747\u80fd\u591f\u987a\u5229\u5730\u5b8c\u6210\u4e0a\u8ff0\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u8fc7\u7a0b\uff0c\u8fdb\u800c\u4ee5\u4e2d\u7b49\u81f3\u826f\u597d\u7684\u53cd\u5e94\u6536\u7387\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u76ee\u6807\u4ea7\u7269<strong>7<\/strong>\u4ee5\u53ca<strong>12<\/strong>&#8211;<strong>20<\/strong>\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u5bf9\u4e8e\u5404\u7c7b\u5627\u5576\u3001\u54d2\u55ea\u3001\u591a\u73af\u82b3\u9999\u5e95\u7269\u3001\u7acb\u4f53\u62e5\u6324\u7684acrisorcin\u3001\u5404\u7c7b\u7a20\u5408\u7684\u591a\u73af\u5e95\u7269\u4ee5\u53ca\u4e00\u7cfb\u5217\u4e94\u5143\u6742\u73af\u82b3\u80fa\u5e95\u7269\uff0c\u540c\u6837\u80fd\u591f\u826f\u597d\u5730\u517c\u5bb9\u3002\u4e4b\u540e\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u7b56\u7565\u540c\u6837\u80fd\u591f\u5e94\u7528\u4e8e\u5404\u7c7b\u590d\u6742\u751f\u7269\u6d3b\u6027\u5206\u5b50\u7684\u4fee\u9970 (<strong>44<\/strong>&#8211;<strong>53<\/strong>\uff0c38-87% \u53cd\u5e94\u6536\u7387)\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/5-9.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41489 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/5-9-680x852.png\" alt=\"\" width=\"680\" height=\"852\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/5-9-680x852.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/5-9-239x300.png 239w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/5-9.png 743w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>\u540c\u65f6\uff0c\u4f5c\u8005\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u76f8\u5173\u7814\u7a76 (Fig. 3)\uff0c\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u7b56\u7565\u5177\u6709\u4f18\u826f\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/6-8.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41490 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/6-8-680x592.png\" alt=\"\" width=\"680\" height=\"592\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/6-8-680x592.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/6-8-300x261.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/6-8.png 710w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>\u63a5\u4e0b\u6765\uff0c\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c\u5728\u5e95\u7269<strong>64<\/strong>\u4e0e<strong>1<\/strong>\u4e4b\u95f4\u7684\u514b\u7ea7\u89c4\u6a21\u53cd\u5e94\u7814\u7a76\u4e2d\uff0c\u540c\u6837\u80fd\u591f\u83b7\u5f9782%\u6536\u7387\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u4ea7\u7269<strong>32 <\/strong>(Fig. 4a)\u3002\u5e76\u4e14\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u53bb\u6c28\u57fa\u5364\u5316\u7b56\u7565\u80fd\u591f\u6709\u6548\u5730\u5e94\u7528\u4e8e\u76f8\u5e94\u7684\u53bb\u6c28\u57fa\u6eb4\u5316 (Fig. 4b)\u4ee5\u53ca\u53bb\u6c28\u57fa\u6c1f\u5316 (Fig. 4c)\u8fc7\u7a0b\u3002\u6700\u7ec8\uff0c\u4f5c\u8005\u63d0\u51fa\u4e00\u79cd\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Fig. 4d)\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/7-3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41491 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/7-3.png\" alt=\"\" width=\"668\" height=\"339\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/7-3.png 668w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/03\/7-3-300x152.png 300w\" sizes=\"(max-width: 668px) 100vw, 668px\" \/><\/a><\/p>\n<h4><strong>\u603b\u7ed3<\/strong><\/h4>\n<p>\u5fb7\u56fdMax-Planck Institut f\u00fcr Kohlenforschung\u7684J. Cornella\u7814\u7a76\u56e2\u961f\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u5421\u5583\u9393\u76d0\u8bd5\u5242(pyrylium reagent)\u4ee5\u53ca\u4e00\u7cfb\u5217\u4e0d\u540c\u7c7b\u578b\u7684\u6c2f\u8d1f\u79bb\u5b50\u6e90\u4fc3\u8fdb\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u7b56\u7565\u5177\u6709\u6e29\u548c\u7684\u53cd\u5e94\u6761\u4ef6\u3001\u4f18\u826f\u7684\u5316\u5b66\u9009\u62e9\u6027\u4e0e\u5b9e\u9a8c\u64cd\u4f5c\u5b89\u5168\u6027\u4ee5\u53ca\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u7b49\u4f18\u52bf\u3002<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] S. Sklenak, L. Yao, R. I. Cukier, H. Yan, <em>J. Am. Chem. Soc.<\/em> <strong>2004<\/strong>, <em>126<\/em>, 14879. doi: <a href=\"https:\/\/doi.org\/10.1021\/ja046462k\">10.1021\/ja046462k<\/a>.<\/li>\n<li>[2] T. Ko, J. Lin, C. Hu, Y. Hsu, A. H. Wang, S. Liaw, <em>J. Biol. Chem. <\/em><strong>2003<\/strong>, <em>278<\/em>, 19111. doi: <a href=\"https:\/\/doi.org\/10.1074\/jbc.M300874200\">10.1074\/jbc.M300874200<\/a>.<\/li>\n<li>[3] D. C. Blakemore, L. Castro, I. Churcher, D. C. Rees, A. W. Thomas, D. M. Wilson, A. Wood, <em>Nat. Chem. <\/em><strong>2018<\/strong>, <em>10<\/em>, 383. doi: <a href=\"https:\/\/www.nature.com\/articles\/s41557-018-0021-z?utm_source=xmol&amp;utm_medium=affiliate&amp;utm_content=meta&amp;utm_campaign=DDCN_1_GL01_metadata\">10.1038\/s41557-018-0021-z.<\/a><\/li>\n<li>[4] J. W. Bode, <em>Acc. Chem. Res.<\/em> <strong>2017<\/strong>,<em> 50<\/em>, 2104. doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.accounts.7b00277\">10.1021\/acs.accounts.7b00277<\/a><\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005:\u6749\u6749 \u5bfc\u8bfb \u8fd1\u65e5\uff0c\u5fb7\u56fdMax-Planck Institut f\u00fcr Kohlenforschung\u7684J. Cornella\u7814\u7a76\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u5421\u5583\u9393\u76d0\u8bd5\u5242 (pyrylium reagent)\u4ee5\u53ca\u4e00\u7cfb\u5217\u4e0d\u540c\u7c7b\u578b\u7684\u6c2f\u8d1f\u79bb\u5b50\u6e90\u53c2\u4e0e\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u5408\u6210\u8f6c\u5316\u7b56\u7565\u5177\u6709\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\u3001\u5e7f\u6cdb\u7684\u5e95\u7269\u5e94\u7528\u8303\u56f4\u3001\u826f\u597d\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u5b9e\u9a8c\u64cd\u4f5c\u5b89\u5168\u6027\u7b49\u4f18\u52bf\u3002 Deaminative chlorination of aminoheterocycles Ghiazza , T. Faber, A. G\u00f3mez-Palomino, J. Cornella, Nat. Chem. 2021, ASAP. doi: 10.1038\/s41557-021-00812-0. \u6b63\u6587 \u76ee\u524d\uff0c\u8bbe\u8ba1\u4e00\u79cd\u80fd\u591f\u5728\u5404\u7c7b\u590d\u6742\u6709\u673a\u5206\u5b50\u4e2d\u9ad8\u6548\u5730\u5f15\u5165\u4e0e\u53bb\u9664\u4e00\u7cfb\u5217\u4e0d\u540c\u5b98\u80fd\u56e2\u7684\u5408\u6210\u8f6c\u5316\u7b56\u7565\uff0c\u4ecd\u9762\u4e34\u8bf8\u591a\u6311\u6218\u3002\u8fd9\u91cc\uff0c\u53d7\u5230\u901a\u8fc7\u53bb\u6c28\u9176 (deaminase)\u50ac\u5316\u7684\u9009\u62e9\u6027\u53bb\u6c28\u57fa\u5316\u8fc7\u7a0b (deaminative process, Fig. 1)[1]-[4]\u4ee5\u53ca\u7ecf\u5178\u7684Vilsmeier\u53cd\u5e94\u65b9\u6cd5\u5b66\u76f8\u5173\u7814\u7a76\u7684\u542f\u53d1\uff0cJ. Cornella\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u5421\u5583\u9393\u76d0\u8bd5\u5242 (pyrylium reagent)\u4ee5\u53ca\u4e00\u7cfb\u5217\u4e0d\u540c\u7c7b\u578b\u7684\u6c2f\u8d1f\u79bb\u5b50\u6e90\u53c2\u4e0e\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u9009\u62e9\u5641\u5511\u5316\u5408\u72699\u4e0ePyry-BF4(1)\u539f\u4f4d\u5f62\u6210\u7684\u56db\u6c1f\u787c\u9178\u5421\u5576\u9393\u76d010\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009\uff0c\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528HCl (\u53cd\u5e94\u6e29\u5ea6\u4e3a25 oC)\u3001MgCl2 (\u53cd\u5e94\u6e29\u5ea6\u4e3a80 oC)\u3001TMSCl (\u53cd\u5e94\u6e29\u5ea6\u4e3a50 oC)\u6216nBu4NCl (\u53cd\u5e94\u6e29\u5ea6\u4e3a120 oC)\u4f5c\u4e3a\u6c2f\u8d1f\u79bb\u5b50\u6e90\uff0cMeCN\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u8fdb\u800c\u4ee5\u4f18\u826f\u7684\u53cd\u5e94\u6536\u7387\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u4ea7\u7269\u3002 \u5728\u83b7\u5f97\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e4b\u540e\uff0c\u4f5c\u8005\u5f00\u59cb\u5bf9\u5404\u7c7b\u6c28\u57fa\u6742\u73af\u5e95\u7269\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u8003\u5bdf (Table 1)\u3002\u9996\u5148\uff0c\u7814\u7a76\u53d1\u73b0\uff0c\u4e0a\u8ff0\u7684\u6807\u51c6\u53cd\u5e94\u4f53\u7cfb\u5bf9\u4e8e\u4e00\u7cfb\u5217\u5177\u6709\u4e0d\u540c\u57fa\u56e2\u53d6\u4ee3\u76842-\u4ee5\u53ca4-\u6c28\u57fa\u5421\u5576\u5e95\u7269\uff0c\u5747\u80fd\u591f\u987a\u5229\u5730\u5b8c\u6210\u4e0a\u8ff0\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u8fc7\u7a0b\uff0c\u8fdb\u800c\u4ee5\u4e2d\u7b49\u81f3\u826f\u597d\u7684\u53cd\u5e94\u6536\u7387\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u76ee\u6807\u4ea7\u72697\u4ee5\u53ca12&#8211;20\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u5bf9\u4e8e\u5404\u7c7b\u5627\u5576\u3001\u54d2\u55ea\u3001\u591a\u73af\u82b3\u9999\u5e95\u7269\u3001\u7acb\u4f53\u62e5\u6324\u7684acrisorcin\u3001\u5404\u7c7b\u7a20\u5408\u7684\u591a\u73af\u5e95\u7269\u4ee5\u53ca\u4e00\u7cfb\u5217\u4e94\u5143\u6742\u73af\u82b3\u80fa\u5e95\u7269\uff0c\u540c\u6837\u80fd\u591f\u826f\u597d\u5730\u517c\u5bb9\u3002\u4e4b\u540e\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u7b56\u7565\u540c\u6837\u80fd\u591f\u5e94\u7528\u4e8e\u5404\u7c7b\u590d\u6742\u751f\u7269\u6d3b\u6027\u5206\u5b50\u7684\u4fee\u9970 (44&#8211;53\uff0c38-87% \u53cd\u5e94\u6536\u7387)\u3002 \u540c\u65f6\uff0c\u4f5c\u8005\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u76f8\u5173\u7814\u7a76 (Fig. 3)\uff0c\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u7b56\u7565\u5177\u6709\u4f18\u826f\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u3002 \u63a5\u4e0b\u6765\uff0c\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c\u5728\u5e95\u726964\u4e0e1\u4e4b\u95f4\u7684\u514b\u7ea7\u89c4\u6a21\u53cd\u5e94\u7814\u7a76\u4e2d\uff0c\u540c\u6837\u80fd\u591f\u83b7\u5f9782%\u6536\u7387\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u4ea7\u726932 (Fig. 4a)\u3002\u5e76\u4e14\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u53bb\u6c28\u57fa\u5364\u5316\u7b56\u7565\u80fd\u591f\u6709\u6548\u5730\u5e94\u7528\u4e8e\u76f8\u5e94\u7684\u53bb\u6c28\u57fa\u6eb4\u5316 (Fig. 4b)\u4ee5\u53ca\u53bb\u6c28\u57fa\u6c1f\u5316 (Fig. 4c)\u8fc7\u7a0b\u3002\u6700\u7ec8\uff0c\u4f5c\u8005\u63d0\u51fa\u4e00\u79cd\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Fig. 4d)\u3002 \u603b\u7ed3 \u5fb7\u56fdMax-Planck Institut f\u00fcr Kohlenforschung\u7684J. Cornella\u7814\u7a76\u56e2\u961f\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u5421\u5583\u9393\u76d0\u8bd5\u5242(pyrylium reagent)\u4ee5\u53ca\u4e00\u7cfb\u5217\u4e0d\u540c\u7c7b\u578b\u7684\u6c2f\u8d1f\u79bb\u5b50\u6e90\u4fc3\u8fdb\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u53bb\u6c28\u57fa\u6c2f\u5316\u7b56\u7565\u5177\u6709\u6e29\u548c\u7684\u53cd\u5e94\u6761\u4ef6\u3001\u4f18\u826f\u7684\u5316\u5b66\u9009\u62e9\u6027\u4e0e\u5b9e\u9a8c\u64cd\u4f5c\u5b89\u5168\u6027\u4ee5\u53ca\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u7b49\u4f18\u52bf\u3002 \u53c2\u8003\u6587\u732e [1] S. Sklenak, L. Yao, R. I. Cukier, H. Yan, J. Am. Chem. Soc. 2004, 126, 14879. doi: 10.1021\/ja046462k. [2] T. Ko, J. Lin, C. Hu, Y. Hsu, A. H. Wang, S. Liaw, J. Biol. Chem. 2003, 278, 19111. 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