{"id":41721,"date":"2022-05-09T08:00:25","date_gmt":"2022-05-09T00:00:25","guid":{"rendered":"\/\/www.gsbet888.com\/?p=41721"},"modified":"2022-05-08T21:47:50","modified_gmt":"2022-05-08T13:47:50","slug":"%e9%93%9c%e5%82%ac%e5%8c%96%e7%9a%84%e6%b0%a8%e5%9f%ba%e7%a3%ba%e9%85%b0%e5%8c%96%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2022\/05\/%e9%93%9c%e5%82%ac%e5%8c%96%e7%9a%84%e6%b0%a8%e5%9f%ba%e7%a3%ba%e9%85%b0%e5%8c%96%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6%e7%a0%94%e7%a9%b6.html","title":{"rendered":"\u94dc\u50ac\u5316\u7684\u6c28\u57fa\u78fa\u9170\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u7814\u7a76"},"content":{"rendered":"<p>\u672c\u6587\u4f5c\u8005:Duece<\/p>\n<h4 style=\"font-weight: 400;\"><strong>\u5bfc\u8bfb<\/strong><\/h4>\n<p style=\"font-weight: 400;\">\u8fd1\u65e5\uff0c\u9075\u4e49\u533b\u79d1\u5927\u5b66\u7684\u9648\u6c38\u6b63\u5c0f\u7ec4\u5728<em>Org. Lett.<\/em><em>\u4e2d<\/em>\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u94dc\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u4e00\u7cfb\u5217<em>O<\/em>-homoallyl\u00a0benzimidate\u6216<em>N<\/em>-alkenyl\u00a0amidine\u4e0e\u4e9a\u78fa\u9178\u94a0 (sodium sulfinate)\u4e4b\u95f4\u7684\u6c28\u57fa\u78fa\u9170\u5316 (aminosulfonylation)\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u6709\u673a\u6742\u73af\u5206\u5b50\u7684\u6784\u5efa\u3002<\/p>\n<blockquote>\n<p style=\"font-weight: 400;\">Complementary Copper-Catalyzed and Electrochemical Aminosulfonylation of O\u2011Homoallyl Benzimidates and N\u2011Alkenyl Amidines with Sodium Sulfinates.<\/p>\n<p>Mou, L. Ren, M. Zhang, M. Wang, Y. Jin, Q. Guan, A. Cai, S. Zhang, H. Ren, Y. Zhang, Y. Chen, <em>Org. Lett.<\/em> <strong>2022<\/strong>, <em>24<\/em>, 1405. doi: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.orglett.2c00287\">10.1021\/acs.orglett.2c00287<\/a>.<\/p><\/blockquote>\n<h4 style=\"font-weight: 400;\"><strong>\u6b63\u6587<\/strong><\/h4>\n<p style=\"font-weight: 400;\">\u76ee\u524d\uff0c\u5bf9\u4e8e\u9ad8\u5ea6\u5b98\u80fd\u56e2\u5316\u7684<em>N<\/em>-\u6742\u73af\u5206\u5b50\u5408\u6210\u8f6c\u5316\u7b56\u7565\u7684\u76f8\u5173\u7814\u7a76\u4e00\u76f4\u4ee5\u6765\u5907\u53d7\u6709\u673a\u5408\u6210\u5316\u5b66\u5bb6\u7684\u5e7f\u6cdb\u5173\u6ce8<sup>[1]-[5]<\/sup> (Scheme 1)\u3002\u8fd9\u91cc\uff0c\u53d7\u5230Chen\u4e0eHe\u7814\u7a76\u56e2\u961f\u5bf9\u4e8e\u5168\u6c1f\u70f7\u57fa\u81ea\u7531\u57fa\u4fc3\u8fdb\u7684\u5206\u5b50\u5185\u6c28\u57fa\u5316\u73af\u5316 (intramolecular aminative cyclization)\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[6]<\/sup>\u3001\u672c\u8bfe\u9898\u7ec4\u524d\u671f\u5bf9\u4e8e\u7eff\u8272\u5316\u5b66\u4e0e\u751f\u7269\u6d3b\u6027\u542b\u6c2e\u6742\u73af\u5206\u5b50 (bioactive azaheterocycles)\u7684\u5408\u6210\u65b9\u6cd5\u5b66<sup>[7]<\/sup>\u4ee5\u53ca\u901a\u8fc7\u70ef\u57fa\u5316\u5408\u7269\u8fdb\u884c\u7684\u5206\u5b50\u5185\u6c28\u57fa\u5316\u53cc\u91cd\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[8]<\/sup>\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u9075\u4e49\u533b\u79d1\u5927\u5b66\u7684\u6731\u6c38\u6b63\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u94dc\u50ac\u5316\u5242\u4ee5\u53ca\u7535\u5316\u5b66\u6761\u4ef6\u4fc3\u8fdb\u7684<em>O<\/em>-homoallyl\u00a0benzimidate\u4ee5\u53ca<em>N<\/em>-alkenyl\u00a0amidine\u4e0e\u4e9a\u78fa\u9178\u94a0\u4e4b\u95f4\u7684\u6c28\u57fa\u78fa\u9170\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/2-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41716 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/2-1-680x1015.png\" alt=\"\" width=\"680\" height=\"1015\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/2-1-680x1015.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/2-1-201x300.png 201w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/2-1-768x1147.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/2-1.png 866w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"font-weight: 400;\">\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528<em>O<\/em>-homoallyl\u00a0benzimidate\u6216<em>N<\/em>-alkenyl\u00a0amidine\u4e0e\u82b3\u57fa\u4e9a\u78fa\u9178\u94a0\u4e3a\u6a21\u677f\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009\uff0c\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a(1) Condition A\uff1a\u5728\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u91c7\u7528Cu(OAc)<sub>2<\/sub>\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cDPP (diphenyl hydrogen phosphate)\u4f5c\u4e3a\u914d\u4f53\uff0cAg<sub>2<\/sub>CO<sub>3<\/sub>\u4f5c\u4e3a\u6c27\u5316\u5242\uff0cMeCN\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a60 \u00b0C\uff1b(2) Condition B\uff1a\u5728\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u91c7\u7528Cu(OAc)<sub>2<\/sub>\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cAg<sub>2<\/sub>CO<sub>3<\/sub>\u4f5c\u4e3a\u6c27\u5316\u5242\uff0cMeCN\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a60 \u00b0C\uff1b(3) Condition C\uff1a\u5728\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u91c7\u7528\u56db\u6c1f\u787c\u9178\u56db\u4e01\u57fa\u94f5\u4f5c\u4e3a\u652f\u6301\u7535\u89e3\u8d28\uff0c\u77f3\u58a8\u68d2 (graphite rod)\u4f5c\u4e3a\u9633\u6781\uff0c\u94c2\u677f\u4f5c\u4e3a\u9634\u6781 (platinum plate)\uff0c\u6052\u5b9a\u7535\u6d41\u4e3a4 mA\uff0cMeCN\/H<sub>2<\/sub>O (12:1 v\/v)\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u8fdb\u800c\u4ee5\u826f\u597d\u7684\u5206\u79bb\u6536\u7387\u83b7\u5f97\u76f8\u5e94\u7684\u73af\u5316\u4ea7\u7269\u3002<\/p>\n<p><span style=\"font-weight: 400;\">\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6<\/span><span style=\"font-weight: 400;\"> (Condition A)<\/span><span style=\"font-weight: 400;\">\u4e0b\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u5bf9\u4e00\u7cfb\u5217<\/span><em style=\"font-weight: 400;\">O<\/em><span style=\"font-weight: 400;\">-homoallyl\u00a0benzimidate<\/span><span style=\"font-weight: 400;\">\u5e95\u7269\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u5982\u4e0b\u7814\u7a76<\/span><span style=\"font-weight: 400;\"> (Scheme 2)<\/span><span style=\"font-weight: 400;\">\u3002<\/span><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG753.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41717 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG753-680x808.jpeg\" alt=\"\" width=\"680\" height=\"808\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG753-680x808.jpeg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG753-252x300.jpeg 252w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG753-768x913.jpeg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG753.jpeg 892w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"font-weight: 400;\">\u540c\u65f6\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u5bf9\u5176\u4ed6\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6 (Condition B-C)\u4e0b\uff0c\u76f8\u5173<em>O<\/em>-homoallyl\u00a0benzimidate\u5e95\u7269\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76 (Scheme 3)\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG754.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41719 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG754-680x271.jpeg\" alt=\"\" width=\"680\" height=\"271\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG754-680x271.jpeg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG754-300x120.jpeg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG754-768x306.jpeg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG754.jpeg 858w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG755.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41718 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG755-680x927.jpeg\" alt=\"\" width=\"680\" height=\"927\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG755-680x927.jpeg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG755-220x300.jpeg 220w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG755-768x1047.jpeg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG755.jpeg 854w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"font-weight: 400;\">\u00a0\u540c\u65f6\uff0c\u4f5c\u8005\u5bf9\u76f8\u5e94\u6742\u73af\u4ea7\u7269\u7684\u5408\u6210\u8f6c\u5316\u8fc7\u7a0b\u8fdb\u884c\u8fdb\u4e00\u6b65\u8003\u5bdf (Scheme 4A)\u3002\u4e4b\u540e\uff0c\u4f5c\u8005\u901a\u8fc7\u4e00\u7cfb\u5217\u63a7\u5236\u5b9e\u9a8c\u7684\u76f8\u5173\u7814\u7a76\u8868\u660e\uff0c\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u6d89\u53ca\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53 (Scheme 4B)\u3002\u540c\u65f6\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7CV (cyclic voltammetry)\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u4e9a\u78fa\u9178\u76d0\u5728\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u4f18\u5148\u53c2\u4e0e\u76f8\u5173\u7684\u6c27\u5316\u8fc7\u7a0b\uff0c\u8fdb\u800c\u5f62\u6210\u76f8\u5e94\u7684\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53 (Scheme 4C)\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\u4ee5\u53ca\u524d\u671f\u76f8\u5173\u7684\u7814\u7a76\u62a5\u9053<sup>[2], [6], [8]<\/sup>\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 4D)\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG752.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41720 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG752-576x1024.jpeg\" alt=\"\" width=\"576\" height=\"1024\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG752-576x1024.jpeg 576w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG752-169x300.jpeg 169w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/05\/WechatIMG752.jpeg 750w\" sizes=\"(max-width: 576px) 100vw, 576px\" \/><\/a><\/p>\n<h4 style=\"font-weight: 400;\"><strong>\u603b\u7ed3<\/strong><\/h4>\n<p style=\"font-weight: 400;\">\u9075\u4e49\u533b\u79d1\u5927\u5b66\u7684\u9648\u6c38\u6b63\u5c0f\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u94dc\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u4e00\u7cfb\u5217<em>O<\/em>-homoallyl\u00a0benzimidate\u6216<em>N<\/em>-alkenyl\u00a0amidine\u5206\u5b50\u4e0e\u4e9a\u78fa\u9178\u94a0\u4e4b\u95f4\u7684\u6c28\u57fa\u78fa\u9170\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6709\u6548\u5730\u5b9e\u73b0\u4e00\u7cfb\u5217\u6709\u673a\u6742\u73af\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u6c28\u57fa\u78fa\u9170\u5316\u7b56\u7565\u5177\u6709\u826f\u597d\u7684\u5e95\u7269\u517c\u5bb9\u6027\u3001\u8f83\u9ad8\u7684\u53cd\u5e94\u6536\u7387\u4ee5\u53ca\u826f\u597d\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u7b49\u4f18\u52bf\u3002<\/p>\n<h4 style=\"font-weight: 400;\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li style=\"font-weight: 400;\">[1] D. Brown, J. Bostr\u00f6m, <em>J. Med. Chem.<\/em> <strong>2016<\/strong>, <em>59<\/em>, 4443.<\/li>\n<li style=\"font-weight: 400;\">doi: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.5b01409\">10.1021\/acs.jmedchem.5b01409.<\/a><\/li>\n<li style=\"font-weight: 400;\">[2] Z. Li, G. Fang, Q, Gu, X. Liu, <em>Chem. Soc. Rev.<\/em> <strong>2020<\/strong>, <em>49<\/em>, 32.<\/li>\n<li style=\"font-weight: 400;\">doi: <a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2020\/CS\/C9CS00681H\">10.1039\/C9CS00681H.<\/a><\/li>\n<li style=\"font-weight: 400;\">[3] R. Mao, Z. Yuan, Y. Li, J. Wu, <em>Chem. &#8211; Eur. J<\/em>. <strong>2017<\/strong>, <em>23<\/em>, 8176.<\/li>\n<li style=\"font-weight: 400;\">doi: <a href=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/chem.201702040\">10.1002\/chem.201702040.<\/a><\/li>\n<li style=\"font-weight: 400;\">[4] S. Ye, X. Li, W. Xie, J. Wu. <em>Eur. J. Org. Chem.<\/em> <strong>2020<\/strong>, <em>2020<\/em>, 1274.<\/li>\n<li style=\"font-weight: 400;\">doi: <a href=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/ejoc.201900396\">10.1002\/ejoc.201900396.<\/a><\/li>\n<li style=\"font-weight: 400;\">[5] X. Xu, K. D. Moeller, <em>J. Am. Chem. Soc.<\/em> <strong>2008<\/strong>, <em>130<\/em>, 13542.<\/li>\n<li style=\"font-weight: 400;\">doi: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja806259z\">10.1021\/ja806259z.<\/a><\/li>\n<li style=\"font-weight: 400;\">[6] X. Mou, F. Rong, H. Zhang, G. Chen, G. He.<em> Org. Lett.<\/em> <strong>2019<\/strong>, <em>21<\/em>, 4657.<\/li>\n<li style=\"font-weight: 400;\">doi: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.orglett.9b01552\">10.1021\/acs.orglett.9b01552.<\/a><\/li>\n<li style=\"font-weight: 400;\">[7] (a) H. Cui, L. Xie, N. Wan, Q. He, Z. Li, Y. Chen, <em>Green Chem. <\/em><strong>2019<\/strong>, <em>21<\/em>, 4324. doi: <a href=\"https:\/\/doi.org\/10.1039\/C9GC01802F\">10.1039\/C9GC01802F<\/a>.<\/li>\n<li style=\"font-weight: 400;\">(b) S. Yang, W. Han, C. He, B. Cui, N. Wan, Y. Chen, <em>Org. Lett.<\/em> <strong>2019<\/strong>, <em>21<\/em>, 8857.<\/li>\n<li style=\"font-weight: 400;\">doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.9b03565\">10.1021\/acs.orglett.9b03565<\/a>.<\/li>\n<li style=\"font-weight: 400;\">(c) F. Zhang, N. Wan, J. Ma, B. Cui, W. Han, Y. Chen, <em>ACS Catal.<\/em> <strong>2021<\/strong>, <em>11<\/em>, 9066.<\/li>\n<li style=\"font-weight: 400;\">doi: <a href=\"https:\/\/doi.org\/10.1021\/acscatal.1c02345\">10.1021\/acscatal.1c02345<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[8] (a) H. Xu, K. D. Moeller, <em>J. Am. Chem. Soc. <\/em><strong>2008<\/strong>, <em>130<\/em>, 13542.<\/li>\n<li style=\"font-weight: 400;\">doi: <a href=\"https:\/\/doi.org\/10.1021\/ja806259z\">10.1021\/ja806259z<\/a>.<\/li>\n<li style=\"font-weight: 400;\">(b) P. Xiong, H. Xu, H. Xu, <em>J. Am. Chem. Soc. <\/em><strong>2017<\/strong>, <em>139<\/em>, 2956.<\/li>\n<li style=\"font-weight: 400;\">doi: <a href=\"https:\/\/doi.org\/10.1021\/jacs.7b01016\">10.1021\/jacs.7b01016<\/a>.<\/li>\n<li style=\"font-weight: 400;\">(c) Y. Jiang, K. Xu, C. Zeng, <em>Chem. Rev.<\/em> <strong>2018<\/strong>, <em>118<\/em>, 4485.<\/li>\n<li style=\"font-weight: 400;\">doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.chemrev.7b00271\">10.1021\/acs.chemrev.7b00271<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[8] (a) R. Zhu, S. L. Buchwald, <em>J. Am. Chem. Soc.<\/em> <strong>2015<\/strong>, <em>137<\/em>, 8069.<\/li>\n<li style=\"font-weight: 400;\">doi: <a href=\"https:\/\/doi.org\/10.1021\/jacs.5b04821\">10.1021\/jacs.5b04821<\/a>.<\/li>\n<li style=\"font-weight: 400;\">(b) W. Rao, L. Jiang, X. Liu, M. Chen, F. Chen, X. Jiang, J. Zhao, G. Zou, Y. Zhou, L. Tang, <em>Org. Lett<\/em>. <strong>2019<\/strong>, <em>21<\/em>, 2890. doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.9b00907\">10.1021\/acs.orglett.9b00907<\/a>.<\/li>\n<li style=\"font-weight: 400;\">(c) M. Yan, Y. Kawamata, P. S. Baran, <em>Chem. Rev.<\/em> <strong>2017<\/strong>, <em>117<\/em>, 13230.<\/li>\n<li style=\"font-weight: 400;\">doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.chemrev.7b00397\">10.1021\/acs.chemrev.7b00397<\/a>.<\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005:Duece \u5bfc\u8bfb \u8fd1\u65e5\uff0c\u9075\u4e49\u533b\u79d1\u5927\u5b66\u7684\u9648\u6c38\u6b63\u5c0f\u7ec4\u5728Org. Lett.\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u94dc\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u4e00\u7cfb\u5217O-homoallyl\u00a0benzimidate\u6216N-alkenyl\u00a0amidine\u4e0e\u4e9a\u78fa\u9178\u94a0 (sodium sulfinate)\u4e4b\u95f4\u7684\u6c28\u57fa\u78fa\u9170\u5316 (aminosulfonylation)\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u6709\u673a\u6742\u73af\u5206\u5b50\u7684\u6784\u5efa\u3002 Complementary Copper-Catalyzed and Electrochemical Aminosulfonylation of O\u2011Homoallyl Benzimidates and N\u2011Alkenyl Amidines with Sodium Sulfinates. Mou, L. Ren, M. Zhang, M. Wang, Y. Jin, Q. Guan, A. Cai, S. Zhang, H. Ren, Y. Zhang, Y. Chen, Org. Lett. 2022, 24, 1405. doi: 10.1021\/acs.orglett.2c00287. \u6b63\u6587 \u76ee\u524d\uff0c\u5bf9\u4e8e\u9ad8\u5ea6\u5b98\u80fd\u56e2\u5316\u7684N-\u6742\u73af\u5206\u5b50\u5408\u6210\u8f6c\u5316\u7b56\u7565\u7684\u76f8\u5173\u7814\u7a76\u4e00\u76f4\u4ee5\u6765\u5907\u53d7\u6709\u673a\u5408\u6210\u5316\u5b66\u5bb6\u7684\u5e7f\u6cdb\u5173\u6ce8[1]-[5] (Scheme 1)\u3002\u8fd9\u91cc\uff0c\u53d7\u5230Chen\u4e0eHe\u7814\u7a76\u56e2\u961f\u5bf9\u4e8e\u5168\u6c1f\u70f7\u57fa\u81ea\u7531\u57fa\u4fc3\u8fdb\u7684\u5206\u5b50\u5185\u6c28\u57fa\u5316\u73af\u5316 (intramolecular aminative cyclization)\u53cd\u5e94\u65b9\u6cd5\u5b66[6]\u3001\u672c\u8bfe\u9898\u7ec4\u524d\u671f\u5bf9\u4e8e\u7eff\u8272\u5316\u5b66\u4e0e\u751f\u7269\u6d3b\u6027\u542b\u6c2e\u6742\u73af\u5206\u5b50 (bioactive azaheterocycles)\u7684\u5408\u6210\u65b9\u6cd5\u5b66[7]\u4ee5\u53ca\u901a\u8fc7\u70ef\u57fa\u5316\u5408\u7269\u8fdb\u884c\u7684\u5206\u5b50\u5185\u6c28\u57fa\u5316\u53cc\u91cd\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66[8]\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u9075\u4e49\u533b\u79d1\u5927\u5b66\u7684\u6731\u6c38\u6b63\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u94dc\u50ac\u5316\u5242\u4ee5\u53ca\u7535\u5316\u5b66\u6761\u4ef6\u4fc3\u8fdb\u7684O-homoallyl\u00a0benzimidate\u4ee5\u53caN-alkenyl\u00a0amidine\u4e0e\u4e9a\u78fa\u9178\u94a0\u4e4b\u95f4\u7684\u6c28\u57fa\u78fa\u9170\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528O-homoallyl\u00a0benzimidate\u6216N-alkenyl\u00a0amidine\u4e0e\u82b3\u57fa\u4e9a\u78fa\u9178\u94a0\u4e3a\u6a21\u677f\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009\uff0c\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a(1) Condition A\uff1a\u5728\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u91c7\u7528Cu(OAc)2\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cDPP (diphenyl hydrogen phosphate)\u4f5c\u4e3a\u914d\u4f53\uff0cAg2CO3\u4f5c\u4e3a\u6c27\u5316\u5242\uff0cMeCN\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a60 \u00b0C\uff1b(2) Condition B\uff1a\u5728\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u91c7\u7528Cu(OAc)2\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cAg2CO3\u4f5c\u4e3a\u6c27\u5316\u5242\uff0cMeCN\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a60 \u00b0C\uff1b(3) Condition C\uff1a\u5728\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u91c7\u7528\u56db\u6c1f\u787c\u9178\u56db\u4e01\u57fa\u94f5\u4f5c\u4e3a\u652f\u6301\u7535\u89e3\u8d28\uff0c\u77f3\u58a8\u68d2 (graphite rod)\u4f5c\u4e3a\u9633\u6781\uff0c\u94c2\u677f\u4f5c\u4e3a\u9634\u6781 (platinum plate)\uff0c\u6052\u5b9a\u7535\u6d41\u4e3a4 mA\uff0cMeCN\/H2O (12:1 v\/v)\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u8fdb\u800c\u4ee5\u826f\u597d\u7684\u5206\u79bb\u6536\u7387\u83b7\u5f97\u76f8\u5e94\u7684\u73af\u5316\u4ea7\u7269\u3002 \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6 (Condition A)\u4e0b\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u5bf9\u4e00\u7cfb\u5217O-homoallyl\u00a0benzimidate\u5e95\u7269\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u5982\u4e0b\u7814\u7a76 (Scheme 2)\u3002 \u540c\u65f6\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u5bf9\u5176\u4ed6\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6 (Condition B-C)\u4e0b\uff0c\u76f8\u5173O-homoallyl\u00a0benzimidate\u5e95\u7269\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76 (Scheme 3)\u3002 \u00a0\u540c\u65f6\uff0c\u4f5c\u8005\u5bf9\u76f8\u5e94\u6742\u73af\u4ea7\u7269\u7684\u5408\u6210\u8f6c\u5316\u8fc7\u7a0b\u8fdb\u884c\u8fdb\u4e00\u6b65\u8003\u5bdf (Scheme 4A)\u3002\u4e4b\u540e\uff0c\u4f5c\u8005\u901a\u8fc7\u4e00\u7cfb\u5217\u63a7\u5236\u5b9e\u9a8c\u7684\u76f8\u5173\u7814\u7a76\u8868\u660e\uff0c\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u6d89\u53ca\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53 (Scheme 4B)\u3002\u540c\u65f6\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7CV (cyclic voltammetry)\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u4e9a\u78fa\u9178\u76d0\u5728\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u4f18\u5148\u53c2\u4e0e\u76f8\u5173\u7684\u6c27\u5316\u8fc7\u7a0b\uff0c\u8fdb\u800c\u5f62\u6210\u76f8\u5e94\u7684\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53 (Scheme 4C)\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\u4ee5\u53ca\u524d\u671f\u76f8\u5173\u7684\u7814\u7a76\u62a5\u9053[2], [6], [8]\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 4D)\u3002 \u603b\u7ed3 \u9075\u4e49\u533b\u79d1\u5927\u5b66\u7684\u9648\u6c38\u6b63\u5c0f\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u94dc\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u4e00\u7cfb\u5217O-homoallyl\u00a0benzimidate\u6216N-alkenyl\u00a0amidine\u5206\u5b50\u4e0e\u4e9a\u78fa\u9178\u94a0\u4e4b\u95f4\u7684\u6c28\u57fa\u78fa\u9170\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6709\u6548\u5730\u5b9e\u73b0\u4e00\u7cfb\u5217\u6709\u673a\u6742\u73af\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u6c28\u57fa\u78fa\u9170\u5316\u7b56\u7565\u5177\u6709\u826f\u597d\u7684\u5e95\u7269\u517c\u5bb9\u6027\u3001\u8f83\u9ad8\u7684\u53cd\u5e94\u6536\u7387\u4ee5\u53ca\u826f\u597d\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u7b49\u4f18\u52bf\u3002 \u53c2\u8003\u6587\u732e [1] D. Brown, J. Bostr\u00f6m, J. Med. 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