{"id":42452,"date":"2022-07-28T08:00:28","date_gmt":"2022-07-28T00:00:28","guid":{"rendered":"\/\/www.gsbet888.com\/?p=42452"},"modified":"2022-07-26T19:38:13","modified_gmt":"2022-07-26T11:38:13","slug":"angew%ef%bc%9a%e4%b8%89%e5%8f%96%e4%bb%a3%e7%83%af%e5%9f%ba%e5%8c%96%e5%90%88%e7%89%a9%e7%9a%84ahf%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2022\/07\/angew%ef%bc%9a%e4%b8%89%e5%8f%96%e4%bb%a3%e7%83%af%e5%9f%ba%e5%8c%96%e5%90%88%e7%89%a9%e7%9a%84ahf%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6%e7%a0%94%e7%a9%b6.html","title":{"rendered":"Angew\uff1a\u4e09\u53d6\u4ee3\u70ef\u57fa\u5316\u5408\u7269\u7684AHF\u53cd\u5e94\u65b9\u6cd5\u5b66\u7814\u7a76"},"content":{"rendered":"<p>\u672c\u6587\u4f5c\u8005:\u6749\u6749<\/p>\n<h4 style=\"font-weight: 400;\">\u5bfc\u8bfb<\/h4>\n<p style=\"font-weight: 400;\">\u8fd1\u65e5\uff0c\u5357\u65b9\u79d1\u6280\u5927\u5b66\u7684\u5f20\u7eea\u7a46\u3001\u767d\u7ecd\u6d9b\u8bfe\u9898\u7ec4\u5728<em>Angew. Chem. Int. Ed.<\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u9996\u4f8b\u901a\u8fc7\u94d1-(<em>R<\/em>,<em>S<\/em>)-DTBM-Yanphos\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u91c7\u7528\u73af\u4e19\u57fa\u5b98\u80fd\u56e2\u5316\u7684\u4e09\u53d6\u4ee3\u70ef\u57fa\u5316\u5408\u7269\u53c2\u4e0e\u7684\u9ad8\u5ea6\u5316\u5b66\u9009\u62e9\u6027\u3001\u533a\u57df\u9009\u62e9\u6027\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u7532\u9170\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u73af\u4e19\u57fa\u7ed3\u6784\u5355\u5143\u7684\u624b\u6027\u919b\u5206\u5b50\u7684\u6784\u5efa\u3002<\/p>\n<blockquote>\n<p style=\"font-weight: 400;\">Chemo-, Regio- and Enantioselective Hydroformylation of Cyclopropyl-Functionalized Trisubstituted Alkenes<\/p>\n<p>Li, D. Zhang, R. Zhang, S. Bai, X. Zhang, <em>Angew. Chem. Int. Ed<\/em>. <strong>2022<\/strong>, ASAP. doi:<a href=\"https:\/\/doi.org\/10.1002\/anie.202206577\">10.1002\/anie.202206577<\/a>.<\/p><\/blockquote>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/2-14.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-42445 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/2-14-680x221.png\" alt=\"\" width=\"680\" height=\"221\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/2-14-680x221.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/2-14-300x98.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/2-14.png 689w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<h4 style=\"font-weight: 400;\">\u6b63\u6587<\/h4>\n<p style=\"font-weight: 400;\">\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u7684AHF (asymmetric hydroformylation) \u53cd\u5e94\u53cd\u6cd5\u5b66\u76ee\u524d\u5df2\u7ecf\u53d7\u5230\u8bf8\u591a\u7814\u7a76\u56e2\u961f\u7684\u5e7f\u6cdb\u5173\u6ce8(Scheme 1a)<sup> [1]-[8]<\/sup>\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u4e09\u53d6\u4ee3\u70ef\u57fa\u5316\u5408\u7269\u53c2\u4e0e\u7684AHF\u53cd\u5e94\u53cd\u6cd5\u5b66\uff0c\u5374\u8f83\u5c11\u6709\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053<sup>[9]-[10]<\/sup>\u3002\u540c\u65f6\uff0c\u5177\u6709\u73af\u4e19\u57fa\u7ed3\u6784\u5355\u5143\u7684\u624b\u6027\u5206\u5b50 (Scheme 1b)\u7684\u6784\u5efa\uff0c\u540c\u6837\u9762\u4e34\u5de8\u5927\u7684\u6311\u6218<sup>[11]-[14]<\/sup>\u3002\u8fd9\u91cc\uff0c\u5357\u65b9\u79d1\u6280\u5927\u5b66\u7684\u5f20\u7eea\u7a46\u3001\u767d\u7ecd\u6d9b\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u9996\u4f8b\u901a\u8fc7\u94d1-(<em>R<\/em>,<em>S<\/em>)-DTBM-Yanphos\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u91c7\u7528\u73af\u4e19\u57fa\u5b98\u80fd\u56e2\u5316\u7684\u4e09\u53d6\u4ee3\u70ef\u57fa\u5316\u5408\u7269\u53c2\u4e0e\u7684\u9ad8\u5ea6\u5316\u5b66\u9009\u62e9\u6027\u3001\u533a\u57df\u9009\u62e9\u6027\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u7532\u9170\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66 (Scheme 1c)\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/3-12.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-42446 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/3-12-680x908.png\" alt=\"\" width=\"680\" height=\"908\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/3-12-680x908.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/3-12-225x300.png 225w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/3-12.png 708w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"font-weight: 400;\">\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528\u4e09\u53d6\u4ee3\u70ef\u57fa\u5316\u5408\u7269<strong>1a<\/strong>\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528Rh(acac)(CO)<sub>2<\/sub>\u4f5c\u4e3a\u50ac\u5316\u5242\uff0c(<em>R,S<\/em>)-DTBM-Yanphos\u4f5c\u4e3a\u624b\u6027\u914d\u4f53\uff0c\u7532\u82ef\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0cCO\u4e0eH<sub>2<\/sub>\u538b\u529b\u5747\u4e3a5 bar\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a70<sup>o<\/sup>C\uff0c\u6700\u7ec8\u83b7\u5f9783%\u6536\u7387\u7684\u624b\u6027\u4ea7\u7269<strong>2a <\/strong>(97% ee)\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/4-11.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-42447 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/4-11-680x580.png\" alt=\"\" width=\"680\" height=\"580\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/4-11-680x580.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/4-11-300x256.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/4-11.png 733w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/5-6.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-42448 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/5-6-655x1024.png\" alt=\"\" width=\"655\" height=\"1024\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/5-6-655x1024.png 655w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/5-6-192x300.png 192w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/5-6.png 725w\" sizes=\"(max-width: 655px) 100vw, 655px\" \/><\/a><\/p>\n<p style=\"font-weight: 400;\">\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5206\u522b\u5bf9\u4e00\u7cfb\u5217\u4e09\u53d6\u4ee3\u70ef\u57fa\u5e95\u7269 (Scheme 3)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/WechatIMG1048.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-42449 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/WechatIMG1048-680x847.png\" alt=\"\" width=\"680\" height=\"847\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/WechatIMG1048-680x847.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/WechatIMG1048-241x300.png 241w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/WechatIMG1048-768x957.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/WechatIMG1048.png 830w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"font-weight: 400;\">\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684AHF\u7b56\u7565\u5177\u6709\u826f\u597d\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c (Scheme 4)\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/7-6.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-42450 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/7-6-680x873.png\" alt=\"\" width=\"680\" height=\"873\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/7-6-680x873.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/7-6-234x300.png 234w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/7-6.png 731w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"font-weight: 400;\">\u63a5\u4e0b\u6765\uff0c\u57fa\u4e8e\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053<sup>[15]-[16]<\/sup>\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 5)\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/8-5.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-42451 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/8-5-680x505.png\" alt=\"\" width=\"680\" height=\"505\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/8-5-680x505.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/8-5-300x223.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/8-5-265x197.png 265w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/07\/8-5.png 720w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<h4 style=\"font-weight: 400;\">\u603b\u7ed3<\/h4>\n<p style=\"font-weight: 400;\">\u5357\u65b9\u79d1\u6280\u5927\u5b66\u7684\u5f20\u7eea\u7a46\u3001\u767d\u7ecd\u6d9b\u7814\u7a76\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u9996\u4f8b\u901a\u8fc7\u94d1-(<em>R<\/em>,<em>S<\/em>)-DTBM-Yanphos\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u91c7\u7528\u73af\u4e19\u57fa\u5b98\u80fd\u56e2\u5316\u53c2\u4e0e\u7684\u4e09\u53d6\u4ee3\u70ef\u57fa\u5316\u5408\u7269\u7684\u9ad8\u5ea6\u5316\u5b66\u9009\u62e9\u6027\u3001\u533a\u57df\u9009\u62e9\u6027\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u7532\u9170\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u73af\u4e19\u57fa\u7ed3\u6784\u5355\u5143\u7684\u624b\u6027\u919b\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684AHF\u7b56\u7565\u5177\u6709\u5e7f\u6cdb\u7684\u5e95\u7269\u8303\u56f4\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002<\/p>\n<h4 style=\"font-weight: 400;\">\u53c2\u8003\u6587\u732e<\/h4>\n<ul>\n<li style=\"font-weight: 400;\">[1] N. Sakai, S. Mano, K. Nozaki, H. Takaya, <em>J. Am. Chem. Soc. <\/em><strong>1993<\/strong>, <em>115<\/em>, 7033. doi: <a href=\"https:\/\/doi.org\/10.1021\/ja00068a095\">10.1021\/ja00068a095<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[2] A. C. Brezny, C. R. Landis, <em>J. Am. Chem. Soc. <\/em><strong>2017<\/strong>, <em>139<\/em>, 2778. doi: <a href=\"https:\/\/doi.org\/10.1021\/jacs.6b12533\">10.1021\/jacs.6b12533<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[3] (a) A. T. Axtell, C. J. Cobley, J. Klosin, G. T. Whiteker, A. Zanotti-Gerosa, K. A. Abboud, <em>Angew. Chem. Int. Ed. <\/em><strong>2005<\/strong>, <em>44<\/em>, 5834. doi: <a href=\"https:\/\/doi.org\/10.1002\/anie.200501478\">10.1002\/anie.200501478<\/a>.<\/li>\n<li style=\"font-weight: 400;\">(b) X. Zheng, B. Cao, T. Liu, X. Zhang, <em>Adv. Synth. Catal. <\/em><strong>2013<\/strong>, <em>355<\/em>, 679. doi: <a href=\"https:\/\/doi.org\/10.1002\/adsc.201200960\">10.1002\/adsc.201200960<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[4] C. You, S. Li, X. Li, J. Lan, Y. Yang, L. Chung, H. Lv, X. Zhang, <em>J. Am. Chem. Soc. <\/em><strong>2018<\/strong>, <em>140<\/em>, 4977. doi:<a href=\"https:\/\/doi.org\/10.1021\/jacs.8b00275\">10.1021\/jacs.8b00275<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[5] G. M. Noonan, J. A. Fuentes, C. J. Cobley, M. L. Clarke, <em>Angew. Chem. Int. Ed. <\/em><strong>2012<\/strong>, <em>51<\/em>, 2477. doi:<a href=\"https:\/\/doi.org\/10.1002\/anie.201108203\">10.1002\/anie.201108203<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[6] C. Schmitz, K. Holthusen, W. Leitner, G. Franci\u00f2, <em>ACS Catal. <\/em><strong>2016<\/strong>, <em>6<\/em>, 1584. doi: <a href=\"https:\/\/doi.org\/10.1021\/acscatal.5b02846\">10.1021\/acscatal.5b02846<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[7] X. Wang, S. L. Buchwald, <em>J. Am. Chem. Soc. <\/em><strong>2011<\/strong>, <em>133<\/em>, 19080. doi: <a href=\"https:\/\/doi.org\/10.1021\/ja2092689\">10.1021\/ja2092689<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[8] M. Jouffroy, R. Gramage-Doria, D. Armspach, D. Semeril, W. Oberhauser, D. Matt, L. Toupet, <em>Angew. Chem. Int. Ed. <\/em><strong>2014<\/strong>, <em>53<\/em>, 3937. doi: <a href=\"https:\/\/doi.org\/10.1002\/anie.201311291\">10.1002\/anie.201311291<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[9] J. Eshon, F. Foarta, C. R. Landis, J. M. Schomaker, <em>J. Org. Chem. <\/em><strong>2018<\/strong>, <em>83<\/em>, 10207. doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.joc.8b01431\">10.1021\/acs.joc.8b01431<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[10] T. Shin, H. Kim, S. Kim, A. Lee, M. S. Seo, J. Choi, H. Kim, H. Kim, <em>Org. Lett. <\/em><strong>2019<\/strong>, <em>21<\/em>, 5789. doi:<a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.9b01639\">10.1021\/acs.orglett.9b01639<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[11] (a) D. Wang, N. Zhu, P. Chen, Z. Lin, G. Liu, <em>J. Am. Chem. Soc. <\/em><strong>2017<\/strong>, <em>139<\/em>, 15632. doi: <a href=\"https:\/\/doi.org\/10.1021\/jacs.7b09802\">10.1021\/jacs.7b09802<\/a>.<\/li>\n<li style=\"font-weight: 400;\">(b) L. Liu, K. Guo, Y. Tian, C. Yang, Q. Gu, Z. Li, L. Ye, X. Liu, <em>Angew. Chem. Int. Ed. <\/em><strong>2021<\/strong>, <em>60<\/em>, 26710. doi:<a href=\"https:\/\/doi.org\/10.1002\/anie.202110233\">10.1002\/anie.202110233<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[12] (a) V. M. Shoba, J. M. Takacs, <em>J. Am. Chem. Soc. <\/em><strong>2017<\/strong>, <em>139<\/em>, 5740. doi: <a href=\"https:\/\/doi.org\/10.1021\/jacs.7b02581\">10.1021\/jacs.7b02581<\/a>.<\/li>\n<li style=\"font-weight: 400;\">(b) Q. Zhao, X. Wu, F. Yang, P. Yan, J. Xie, Q. Zhou, <em>Org. Lett. <\/em><strong>2021<\/strong>, <em>23<\/em>, 3593. doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.1c00993\">10.1021\/acs.orglett.1c00993<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[13] S. Aichhorn, R. Bigler, E. L. Myers, V. K. Aggarwal, <em>J. Am. Chem. Soc. <\/em><strong>2017<\/strong>, <em>139<\/em>, 9519. doi: <a href=\"https:\/\/doi.org\/10.1021\/jacs.7b05880\">10.1021\/jacs.7b05880<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[14] R. Takechi, T. Nishimura, <em>Chem. Commun. <\/em><strong>2015<\/strong>, <em>51<\/em>, 8528. doi: <a href=\"https:\/\/doi.org\/10.1039\/C5CC02140E\">10.1039\/C5CC02140E<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[15] S. Simaan, I. Marek, <em>J. Am. Chem. Soc. <\/em><strong>2010<\/strong>, <em>132<\/em>, 4066. doi: <a href=\"https:\/\/doi.org\/10.1021\/ja100544c\">10.1021\/ja100544c<\/a>.<\/li>\n<li style=\"font-weight: 400;\">[16] (a) L. A. Aronica, P. Raffa, A. M. Caporusso, P. Salvadori, <em>J. Org. Chem. <\/em><strong>2003<\/strong>, <em>68<\/em>, 9292. doi: <a href=\"https:\/\/doi.org\/10.1021\/jo0351062\">10.1021\/jo0351062<\/a>.<\/li>\n<li style=\"font-weight: 400;\">(b) Q. Zhu, Y. Luo, Y. Guo, Y. Zhang, Y. Tao, <em>J. Org. Chem. <\/em><strong>2021<\/strong>, <em>86<\/em>, 5463. doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.joc.0c02987\">10.1021\/acs.joc.0c02987<\/a>.<\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005:\u6749\u6749 \u5bfc\u8bfb \u8fd1\u65e5\uff0c\u5357\u65b9\u79d1\u6280\u5927\u5b66\u7684\u5f20\u7eea\u7a46\u3001\u767d\u7ecd\u6d9b\u8bfe\u9898\u7ec4\u5728Angew. Chem. Int. Ed.\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u9996\u4f8b\u901a\u8fc7\u94d1-(R,S)-DTBM-Yanphos\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u91c7\u7528\u73af\u4e19\u57fa\u5b98\u80fd\u56e2\u5316\u7684\u4e09\u53d6\u4ee3\u70ef\u57fa\u5316\u5408\u7269\u53c2\u4e0e\u7684\u9ad8\u5ea6\u5316\u5b66\u9009\u62e9\u6027\u3001\u533a\u57df\u9009\u62e9\u6027\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u7532\u9170\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u73af\u4e19\u57fa\u7ed3\u6784\u5355\u5143\u7684\u624b\u6027\u919b\u5206\u5b50\u7684\u6784\u5efa\u3002 Chemo-, Regio- and Enantioselective Hydroformylation of Cyclopropyl-Functionalized Trisubstituted Alkenes Li, D. Zhang, R. Zhang, S. Bai, X. Zhang, Angew. Chem. Int. Ed. 2022, ASAP. doi:10.1002\/anie.202206577. \u6b63\u6587 \u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u7684AHF (asymmetric hydroformylation) \u53cd\u5e94\u53cd\u6cd5\u5b66\u76ee\u524d\u5df2\u7ecf\u53d7\u5230\u8bf8\u591a\u7814\u7a76\u56e2\u961f\u7684\u5e7f\u6cdb\u5173\u6ce8(Scheme 1a) [1]-[8]\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u4e09\u53d6\u4ee3\u70ef\u57fa\u5316\u5408\u7269\u53c2\u4e0e\u7684AHF\u53cd\u5e94\u53cd\u6cd5\u5b66\uff0c\u5374\u8f83\u5c11\u6709\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053[9]-[10]\u3002\u540c\u65f6\uff0c\u5177\u6709\u73af\u4e19\u57fa\u7ed3\u6784\u5355\u5143\u7684\u624b\u6027\u5206\u5b50 (Scheme 1b)\u7684\u6784\u5efa\uff0c\u540c\u6837\u9762\u4e34\u5de8\u5927\u7684\u6311\u6218[11]-[14]\u3002\u8fd9\u91cc\uff0c\u5357\u65b9\u79d1\u6280\u5927\u5b66\u7684\u5f20\u7eea\u7a46\u3001\u767d\u7ecd\u6d9b\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u9996\u4f8b\u901a\u8fc7\u94d1-(R,S)-DTBM-Yanphos\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u91c7\u7528\u73af\u4e19\u57fa\u5b98\u80fd\u56e2\u5316\u7684\u4e09\u53d6\u4ee3\u70ef\u57fa\u5316\u5408\u7269\u53c2\u4e0e\u7684\u9ad8\u5ea6\u5316\u5b66\u9009\u62e9\u6027\u3001\u533a\u57df\u9009\u62e9\u6027\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u7532\u9170\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66 (Scheme 1c)\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528\u4e09\u53d6\u4ee3\u70ef\u57fa\u5316\u5408\u72691a\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528Rh(acac)(CO)2\u4f5c\u4e3a\u50ac\u5316\u5242\uff0c(R,S)-DTBM-Yanphos\u4f5c\u4e3a\u624b\u6027\u914d\u4f53\uff0c\u7532\u82ef\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0cCO\u4e0eH2\u538b\u529b\u5747\u4e3a5 bar\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a70oC\uff0c\u6700\u7ec8\u83b7\u5f9783%\u6536\u7387\u7684\u624b\u6027\u4ea7\u72692a (97% ee)\u3002 \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5206\u522b\u5bf9\u4e00\u7cfb\u5217\u4e09\u53d6\u4ee3\u70ef\u57fa\u5e95\u7269 (Scheme 3)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002 \u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684AHF\u7b56\u7565\u5177\u6709\u826f\u597d\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c (Scheme 4)\u3002 \u63a5\u4e0b\u6765\uff0c\u57fa\u4e8e\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053[15]-[16]\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 5)\u3002 \u603b\u7ed3 \u5357\u65b9\u79d1\u6280\u5927\u5b66\u7684\u5f20\u7eea\u7a46\u3001\u767d\u7ecd\u6d9b\u7814\u7a76\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u9996\u4f8b\u901a\u8fc7\u94d1-(R,S)-DTBM-Yanphos\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u91c7\u7528\u73af\u4e19\u57fa\u5b98\u80fd\u56e2\u5316\u53c2\u4e0e\u7684\u4e09\u53d6\u4ee3\u70ef\u57fa\u5316\u5408\u7269\u7684\u9ad8\u5ea6\u5316\u5b66\u9009\u62e9\u6027\u3001\u533a\u57df\u9009\u62e9\u6027\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u7532\u9170\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u73af\u4e19\u57fa\u7ed3\u6784\u5355\u5143\u7684\u624b\u6027\u919b\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684AHF\u7b56\u7565\u5177\u6709\u5e7f\u6cdb\u7684\u5e95\u7269\u8303\u56f4\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002 \u53c2\u8003\u6587\u732e [1] N. Sakai, S. Mano, K. Nozaki, H. Takaya, J. Am. Chem. Soc. 1993, 115, 7033. doi: 10.1021\/ja00068a095. [2] A. C. Brezny, C. R. Landis, J. Am. Chem. Soc. 2017, 139, 2778. doi: 10.1021\/jacs.6b12533. [3] (a) A. T. Axtell, C. J. Cobley, J. Klosin, G. T. Whiteker, A. Zanotti-Gerosa, K. 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