{"id":43160,"date":"2022-10-10T08:00:04","date_gmt":"2022-10-10T00:00:04","guid":{"rendered":"\/\/www.gsbet888.com\/?p=43160"},"modified":"2022-10-14T21:58:03","modified_gmt":"2022-10-14T13:58:03","slug":"angew%ef%bc%9a%e9%87%91i%e5%82%ac%e5%8c%96%e7%9a%84%e4%b8%b2%e8%81%94%e6%b0%a2%e8%8a%b3%e5%9f%ba%e5%8c%96-nazarov%e7%8e%af%e5%8c%96%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2022\/10\/angew%ef%bc%9a%e9%87%91i%e5%82%ac%e5%8c%96%e7%9a%84%e4%b8%b2%e8%81%94%e6%b0%a2%e8%8a%b3%e5%9f%ba%e5%8c%96-nazarov%e7%8e%af%e5%8c%96%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6%e7%a0%94%e7%a9%b6.html","title":{"rendered":"Angew\uff1a\u91d1(I)\u50ac\u5316\u7684\u4e32\u8054\u6c22\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u7814\u7a76"},"content":{"rendered":"<p>\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n<h4>\u5bfc\u8bfb\uff1a<\/h4>\n<p>\u8fd1\u65e5\uff0c\u897f\u73ed\u7259Burgos\u5927\u5b66\u7684R.\u00a0Sanz\u8bfe\u9898\u7ec4\u5728<em>Angew. Chem. Int. Ed.<\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u624b\u6027\u91d1\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u901a\u8fc7skipped alkenynones\u53c2\u4e0e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4e32\u8054<em><i>anti<\/i><\/em>-Michael\u6c22\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027cyclopentachromenone\u5206\u5b50\u7684\u6784\u5efa\u3002<\/p>\n<blockquote><p>Asymmetric Gold(I)-Catalyzed Tandem Hydroarylation-Nazarov\u00a0Cyclization: Enantioselective Access to Cyclopentenones<\/p>\n<p>M.Solas, S.Su\u00e1rez-Pantiga, R.\u00a0Sanz, <em> Chem. Int. Ed<\/em>.\u00a0<strong>2022<\/strong>, ASAP. doi: <a href=\"https:\/\/doi.org\/10.1002\/anie.202207406\">10.1002\/anie.202207406<\/a>.<\/p><\/blockquote>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43162 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7e6f8cb656cf650f9df186219e016096.png\" alt=\"\" width=\"848\" height=\"207\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7e6f8cb656cf650f9df186219e016096.png 848w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7e6f8cb656cf650f9df186219e016096-300x73.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7e6f8cb656cf650f9df186219e016096-680x166.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7e6f8cb656cf650f9df186219e016096-768x187.png 768w\" sizes=\"(max-width: 848px) 100vw, 848px\" \/><\/p>\n<h4>\u6b63\u6587\uff1a<\/h4>\n<p>\u73af\u620a\u70ef\u916e\u4f5c\u4e3a\u529f\u80fd\u6027\u9aa8\u67b6\u5355\u5143\uff0c\u76ee\u524d\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e00\u7cfb\u5217\u751f\u7269\u6d3b\u6027\u9776\u5206\u5b50\u7684\u6784\u5efa\u3002\u5176\u4e2d\uff0cNazarov\u73af\u5316\u53cd\u5e94\u662f\u6784\u5efa\u73af\u620a\u70ef\u916e\u7c7b\u5206\u5b50\u7684\u6709\u6548\u7b56\u7565\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u5bf9\u6620\u9009\u62e9\u6027Nazarov\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u7684\u76f8\u5173\u7814\u7a76\uff0c\u81f3\u4eca\u4ecd\u9762\u4e34\u8bf8\u591a\u7684\u6311\u6218 (Scheme 1a-b)<sup>[1]-[7]<\/sup>\u3002<\/p>\n<p>\u8fd9\u91cc\uff0c\u53d7\u5230\u672c\u8bfe\u9898\u7ec4\u524d\u671f\u5bf9\u4e8e\u91d1\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u91c7\u7528skipped alkenynone\u53c2\u4e0e\u7684\u4e32\u8054<em>anti<\/em>-Michael\u6c34\u5408\u4e0e<em>endo<\/em>-\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[8]-[9]<\/sup>(Scheme 1c)\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u897f\u73ed\u7259Burgos\u5927\u5b66\u7684R.\u00a0Sanz\u7814\u7a76\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u624b\u6027\u91d1\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u901a\u8fc7skipped alkenynones\u53c2\u4e0e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4e32\u8054<em><i>anti<\/i><\/em>-Michael\u6c22\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66 (Scheme 1d)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43163 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/df5e676ca94de6bbf67d171a13740539.png\" alt=\"\" width=\"913\" height=\"1397\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/df5e676ca94de6bbf67d171a13740539.png 913w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/df5e676ca94de6bbf67d171a13740539-196x300.png 196w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/df5e676ca94de6bbf67d171a13740539-669x1024.png 669w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/df5e676ca94de6bbf67d171a13740539-768x1175.png 768w\" sizes=\"(max-width: 913px) 100vw, 913px\" \/><\/p>\n<p>\u9996\u5148\uff0c\u4f5c\u8005\u5bf9\u4e8e\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4e32\u8054<em><i>anti<\/i><\/em>-Michael\u6c22\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u7684\u53ef\u884c\u6027\u8fdb\u884c\u7814\u7a76 (Scheme 2)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43164 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/0b0deb48dcf181e48209c92365b99432.png\" alt=\"\" width=\"861\" height=\"535\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/0b0deb48dcf181e48209c92365b99432.png 861w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/0b0deb48dcf181e48209c92365b99432-300x186.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/0b0deb48dcf181e48209c92365b99432-680x423.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/0b0deb48dcf181e48209c92365b99432-768x477.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/0b0deb48dcf181e48209c92365b99432-233x144.png 233w\" sizes=\"(max-width: 861px) 100vw, 861px\" \/><\/p>\n<p>\u4e4b\u540e\uff0c\u4f5c\u8005\u91c7\u7528\u70ef\u7094\u916e (alkenynone)\u884d\u751f\u7269<strong>1a<\/strong>\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528L1*(AuCl)<sub>2<\/sub>\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cAgOTf\u4f5c\u4e3a\u94f6\u76d0\uff0cDCE\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a\u5ba4\u6e29\uff0c\u6700\u7ec8\u83b7\u5f9780%\u6536\u7387\u7684cyclopentachromenone\u4ea7\u7269<strong>2a <\/strong>(96% ee)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43166 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/b7f2968f4c23c1c6954d3af4d6fc9baf.png\" alt=\"\" width=\"910\" height=\"1591\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/b7f2968f4c23c1c6954d3af4d6fc9baf.png 910w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/b7f2968f4c23c1c6954d3af4d6fc9baf-172x300.png 172w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/b7f2968f4c23c1c6954d3af4d6fc9baf-586x1024.png 586w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/b7f2968f4c23c1c6954d3af4d6fc9baf-768x1343.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/b7f2968f4c23c1c6954d3af4d6fc9baf-879x1536.png 879w\" sizes=\"(max-width: 910px) 100vw, 910px\" \/><\/p>\n<p>\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217\u70ef\u7094\u916e\u5e95\u7269 (Schemes\u00a03-4)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43167 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/0df55a899ea1f0a8c3a9cae83ce1cfc8-1.png\" alt=\"\" width=\"992\" height=\"704\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/0df55a899ea1f0a8c3a9cae83ce1cfc8-1.png 992w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/0df55a899ea1f0a8c3a9cae83ce1cfc8-1-300x213.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/0df55a899ea1f0a8c3a9cae83ce1cfc8-1-680x483.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/0df55a899ea1f0a8c3a9cae83ce1cfc8-1-768x545.png 768w\" sizes=\"(max-width: 992px) 100vw, 992px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43168 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/790666f56f4a2203fed528f8cd10b03d.png\" alt=\"\" width=\"1010\" height=\"1342\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/790666f56f4a2203fed528f8cd10b03d.png 1010w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/790666f56f4a2203fed528f8cd10b03d-226x300.png 226w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/790666f56f4a2203fed528f8cd10b03d-680x904.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/790666f56f4a2203fed528f8cd10b03d-768x1020.png 768w\" sizes=\"(max-width: 1010px) 100vw, 1010px\" \/><\/p>\n<p>\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u8fdb\u4e00\u6b65\u5bf9\u4e0a\u8ff0\u5bf9\u6620\u9009\u62e9\u6027\u4e32\u8054<em><i>anti<\/i><\/em>-Michael\u6c22\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u7684\u5e95\u7269\u5e94\u7528\u8303\u56f4\u4ee5\u53ca\u8fd9\u4e00\u7b56\u7565\u7684\u5c40\u9650\u6027\u8fdb\u884c\u6df1\u5165\u7814\u7a76 (Scheme 5)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43169 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/8c3b8e3adb4212fae96bdb6e96b03384.png\" alt=\"\" width=\"874\" height=\"808\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/8c3b8e3adb4212fae96bdb6e96b03384.png 874w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/8c3b8e3adb4212fae96bdb6e96b03384-300x277.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/8c3b8e3adb4212fae96bdb6e96b03384-680x629.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/8c3b8e3adb4212fae96bdb6e96b03384-768x710.png 768w\" sizes=\"(max-width: 874px) 100vw, 874px\" \/><\/p>\n<p>\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u4e0d\u5bf9\u79f0\u6c22\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u00a0(Scheme 6)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43170 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7f1a7a60175dde082ad0f70ca76865c3.png\" alt=\"\" width=\"906\" height=\"598\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7f1a7a60175dde082ad0f70ca76865c3.png 906w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7f1a7a60175dde082ad0f70ca76865c3-300x198.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7f1a7a60175dde082ad0f70ca76865c3-680x449.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7f1a7a60175dde082ad0f70ca76865c3-768x507.png 768w\" sizes=\"(max-width: 906px) 100vw, 906px\" \/><\/p>\n<p>\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u901a\u8fc7\u4e00\u7cfb\u5217\u63a7\u5236\u5b9e\u9a8c\u00a0(Scheme 6)\u7684\u76f8\u5173\u7814\u7a76\u8868\u660e\uff0c\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u5e76\u672a\u6d89\u53ca\u6e38\u79bb\u7684\u8272\u70ef\u4e2d\u95f4\u4f53<strong>10<\/strong>\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\u4ee5\u53ca\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053<sup>[7]<\/sup>\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 7)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43171 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/e00e981f6f5e622fedd68e4b4158dfed.png\" alt=\"\" width=\"845\" height=\"863\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/e00e981f6f5e622fedd68e4b4158dfed.png 845w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/e00e981f6f5e622fedd68e4b4158dfed-294x300.png 294w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/e00e981f6f5e622fedd68e4b4158dfed-680x694.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/e00e981f6f5e622fedd68e4b4158dfed-768x784.png 768w\" sizes=\"(max-width: 845px) 100vw, 845px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>\u603b\u7ed3\uff1a\u897f\u73ed\u7259Burgos\u5927\u5b66\u7684R. Sanz\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u624b\u6027\u91d1\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u901a\u8fc7skipped alkenynones\u53c2\u4e0e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4e32\u8054<em><i>anti<\/i><\/em>-Michael\u6c22\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027cyclopentachromenone\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u4e0d\u5bf9\u79f0\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u7b56\u7565\u5177\u6709\u5e7f\u6cdb\u7684\u5e95\u7269\u5e94\u7528\u8303\u56f4\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ul>\n<li>[1] S. P. Simeonov, J. P. M. Nunes, K. Guerra, V. B. Kurteva, C. A. M.\u00a0Afonso, <em><i>Chem. Rev. <\/i><\/em><strong><b>2016<\/b><\/strong>, <em><i>116<\/i><\/em>, 5744.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1021\/cr500504w\"><u>10.1021\/cr500504w<\/u><\/a>.<\/li>\n<li>[2]\u00a0G.\u00a0Liang, D. Trauner, <em><i>J. Am. Chem. Soc. <\/i><\/em><strong><b>2004<\/b><\/strong>, <em><i>126<\/i><\/em>, 9544.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1021\/ja0476664\"><u>10.1021\/ja0476664<\/u><\/a>.<\/li>\n<li>[3]\u00a0M. Rueping, W. Ieawsuwan, A. P. Antonchick, B. J. Nachtsheim, <em><i>Angew.<\/i><\/em><em><i>\u00a0<\/i><\/em><em><i>Chem. Int. Ed. <\/i><\/em><strong><b>2007<\/b><\/strong>, <em><i>46<\/i><\/em>, 2097.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1002\/anie.200604809\"><u>10.1002\/anie.200604809<\/u><\/a>.<\/li>\n<li>[4] Y. Hong, L. Jarrige, K. Harms, E. Meggers, <em><i>J.<\/i><\/em><em><i>\u00a0<\/i><\/em><em><i>Am. Chem. Soc. <\/i><\/em><strong><b>2019<\/b><\/strong>, <em><i>141<\/i><\/em>, 4569.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1021\/jacs.9b01352\"><u>10.1021\/jacs.9b01352<\/u><\/a>.<\/li>\n<li>[5]\u00a0A. Jolit,\u00a0P. M. Walleser, G. P. A. Yap, M. A. Tius, <em><i>Angew. Chem. Int. Ed. <\/i><\/em><strong><b>2014<\/b><\/strong>,\u00a0<em><i>53<\/i><\/em>, 6180.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1002\/anie.201403587\"><u>10.1002\/anie.201403587<\/u><\/a>.<\/li>\n<li>[6] J. Ouyang, J. L. Kennemur, C. K. De, C. Far\u00e8s, B. List, <em><i>J. Am. Chem.<\/i><\/em><em><i>\u00a0<\/i><\/em><em><i>Soc. <\/i><\/em><strong><b>2019<\/b><\/strong>, <em><i>141<\/i><\/em>, 3414.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1021\/jacs.8b13899\"><u>10.1021\/jacs.8b13899<\/u><\/a>.<\/li>\n<li>[7]\u00a0J. Cao, M. Hu, S. Liu, X. Zhang, S.\u00a0Zhu, Q. Zhou, <em><i>J. Am. Chem. Soc. <\/i><\/em><strong><b>2021<\/b><\/strong>, <em><i>143<\/i><\/em>, 6962.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1021\/jacs.1c01194\"><u>10.1021\/jacs.1c01194<\/u><\/a>.<\/li>\n<li>[8]\u00a0M. Solas, S. Su\u00e1rez-Pantiga, R. Sanz, <em><i>Green Chem. <\/i><\/em><strong><b>2019<\/b><\/strong>, <em><i>21<\/i><\/em>, 213.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1039\/C8GC03275K\"><u>10.1039\/C8GC03275K<\/u><\/a>.<\/li>\n<li>[9] M. Solas, M. A. Mu\u00f1oz, S. Su\u00e1rez-Pantiga, R. Sanz, <em><i>Org. Lett. <\/i><\/em><strong><b>2020<\/b><\/strong>, <em><i>22<\/i><\/em>,\u00a07681.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.0c02892\"><u>10.1021\/acs.orglett.0c02892<\/u><\/a>.<\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb\uff1a \u8fd1\u65e5\uff0c\u897f\u73ed\u7259Burgos\u5927\u5b66\u7684R.\u00a0Sanz\u8bfe\u9898\u7ec4\u5728Angew. Chem. Int. Ed.\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u624b\u6027\u91d1\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u901a\u8fc7skipped alkenynones\u53c2\u4e0e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4e32\u8054anti-Michael\u6c22\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027cyclopentachromenone\u5206\u5b50\u7684\u6784\u5efa\u3002 Asymmetric Gold(I)-Catalyzed Tandem Hydroarylation-Nazarov\u00a0Cyclization: Enantioselective Access to Cyclopentenones M.Solas, S.Su\u00e1rez-Pantiga, R.\u00a0Sanz, Chem. Int. Ed.\u00a02022, ASAP. doi: 10.1002\/anie.202207406. \u6b63\u6587\uff1a \u73af\u620a\u70ef\u916e\u4f5c\u4e3a\u529f\u80fd\u6027\u9aa8\u67b6\u5355\u5143\uff0c\u76ee\u524d\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e00\u7cfb\u5217\u751f\u7269\u6d3b\u6027\u9776\u5206\u5b50\u7684\u6784\u5efa\u3002\u5176\u4e2d\uff0cNazarov\u73af\u5316\u53cd\u5e94\u662f\u6784\u5efa\u73af\u620a\u70ef\u916e\u7c7b\u5206\u5b50\u7684\u6709\u6548\u7b56\u7565\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u5bf9\u6620\u9009\u62e9\u6027Nazarov\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u7684\u76f8\u5173\u7814\u7a76\uff0c\u81f3\u4eca\u4ecd\u9762\u4e34\u8bf8\u591a\u7684\u6311\u6218 (Scheme 1a-b)[1]-[7]\u3002 \u8fd9\u91cc\uff0c\u53d7\u5230\u672c\u8bfe\u9898\u7ec4\u524d\u671f\u5bf9\u4e8e\u91d1\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u91c7\u7528skipped alkenynone\u53c2\u4e0e\u7684\u4e32\u8054anti-Michael\u6c34\u5408\u4e0eendo-\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66[8]-[9](Scheme 1c)\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u897f\u73ed\u7259Burgos\u5927\u5b66\u7684R.\u00a0Sanz\u7814\u7a76\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u624b\u6027\u91d1\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u901a\u8fc7skipped alkenynones\u53c2\u4e0e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4e32\u8054anti-Michael\u6c22\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66 (Scheme 1d)\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u5bf9\u4e8e\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4e32\u8054anti-Michael\u6c22\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u7684\u53ef\u884c\u6027\u8fdb\u884c\u7814\u7a76 (Scheme 2)\u3002 \u4e4b\u540e\uff0c\u4f5c\u8005\u91c7\u7528\u70ef\u7094\u916e (alkenynone)\u884d\u751f\u72691a\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528L1*(AuCl)2\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cAgOTf\u4f5c\u4e3a\u94f6\u76d0\uff0cDCE\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a\u5ba4\u6e29\uff0c\u6700\u7ec8\u83b7\u5f9780%\u6536\u7387\u7684cyclopentachromenone\u4ea7\u72692a (96% ee)\u3002 \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217\u70ef\u7094\u916e\u5e95\u7269 (Schemes\u00a03-4)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002 \u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u8fdb\u4e00\u6b65\u5bf9\u4e0a\u8ff0\u5bf9\u6620\u9009\u62e9\u6027\u4e32\u8054anti-Michael\u6c22\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u7684\u5e95\u7269\u5e94\u7528\u8303\u56f4\u4ee5\u53ca\u8fd9\u4e00\u7b56\u7565\u7684\u5c40\u9650\u6027\u8fdb\u884c\u6df1\u5165\u7814\u7a76 (Scheme 5)\u3002 \u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u4e0d\u5bf9\u79f0\u6c22\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u00a0(Scheme 6)\u3002 \u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u901a\u8fc7\u4e00\u7cfb\u5217\u63a7\u5236\u5b9e\u9a8c\u00a0(Scheme 6)\u7684\u76f8\u5173\u7814\u7a76\u8868\u660e\uff0c\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u5e76\u672a\u6d89\u53ca\u6e38\u79bb\u7684\u8272\u70ef\u4e2d\u95f4\u4f5310\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\u4ee5\u53ca\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053[7]\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 7)\u3002 &nbsp; \u603b\u7ed3\uff1a\u897f\u73ed\u7259Burgos\u5927\u5b66\u7684R. Sanz\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u91c7\u7528\u624b\u6027\u91d1\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u901a\u8fc7skipped alkenynones\u53c2\u4e0e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4e32\u8054anti-Michael\u6c22\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027cyclopentachromenone\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u4e0d\u5bf9\u79f0\u82b3\u57fa\u5316-Nazarov\u73af\u5316\u7b56\u7565\u5177\u6709\u5e7f\u6cdb\u7684\u5e95\u7269\u5e94\u7528\u8303\u56f4\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002 \u53c2\u8003\u6587\u732e\uff1a [1] S. P. Simeonov, J. P. M. Nunes, K. Guerra, V. B. Kurteva, C. A. M.\u00a0Afonso, Chem. Rev. 2016, 116, 5744.\u00a0doi:\u00a010.1021\/cr500504w. [2]\u00a0G.\u00a0Liang, D. Trauner, J. Am. Chem. Soc. 2004, 126, 9544.\u00a0doi:\u00a010.1021\/ja0476664. [3]\u00a0M. Rueping, W. Ieawsuwan, A. P. Antonchick, B. J. Nachtsheim, Angew.\u00a0Chem. Int. Ed. 2007, 46, 2097.\u00a0doi:\u00a010.1002\/anie.200604809. [4] Y. Hong, L. 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