{"id":43234,"date":"2022-10-05T19:33:41","date_gmt":"2022-10-05T11:33:41","guid":{"rendered":"\/\/www.gsbet888.com\/?p=43234"},"modified":"2022-10-05T19:37:09","modified_gmt":"2022-10-05T11:37:09","slug":"2022%e5%b9%b4%e8%af%ba%e8%b4%9d%e5%b0%94%e5%8c%96%e5%ad%a6%e5%a5%96%e8%a7%a3%e8%af%bb","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/2022\/10\/2022%e5%b9%b4%e8%af%ba%e8%b4%9d%e5%b0%94%e5%8c%96%e5%ad%a6%e5%a5%96%e8%a7%a3%e8%af%bb.html","title":{"rendered":"2022\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u89e3\u8bfb"},"content":{"rendered":"<p><strong><b>\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><\/p>\n<p><strong>\u5bfc\u8bfb\uff1a<\/strong><\/p>\n<p>\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u4e8e10\u67085\u65e517\u70b945\u5206\u5728\u745e\u5178\u9996\u90fd\u65af\u5fb7\u54e5\u5c14\u6469\u745e\u5178\u7687\u5bb6\u79d1\u5b66\u9662\u63ed\u6653\uff0c\u8bfa\u8d1d\u5c14\u5956\u59d4\u5458\u4f1a\u5c06\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u6388\u4e88\u7f8e\u56fd\u79d1\u5b66\u5bb6Carolyn R. Bertozzi\u3001\u4e39\u9ea6\u79d1\u5b66\u5bb6Morten Meldal\u548c\u7f8e\u56fd\u79d1\u5b66\u5bb6K. Barry Sharpless\uff0c\u83b7\u5956\u7406\u7531\uff1a\u56e0\u201c\u53d1\u5c55\u70b9\u51fb\u5316\u5b66\u548c\u751f\u7269\u6b63\u4ea4\u5316\u5b66&#8221;\u6240\u505a\u51fa\u7684\u7814\u7a76\u8d21\u732e\uff08for the development of click chemistry and bioorthogonal chemistry\uff09\u201d\uff0c\u65e8\u5728\u5c06\u56f0\u96be\u7684\u8fc7\u7a0b\u53d8\u5f97\u66f4\u52a0\u5bb9\u6613(\u56fe 1)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43236 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/c5a3f47f42dc4ad20442c3f00ad138c9.png\" alt=\"\" width=\"1115\" height=\"1115\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/c5a3f47f42dc4ad20442c3f00ad138c9.png 1115w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/c5a3f47f42dc4ad20442c3f00ad138c9-300x300.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/c5a3f47f42dc4ad20442c3f00ad138c9-680x680.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/c5a3f47f42dc4ad20442c3f00ad138c9-150x150.png 150w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/c5a3f47f42dc4ad20442c3f00ad138c9-768x768.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/c5a3f47f42dc4ad20442c3f00ad138c9-120x120.png 120w\" sizes=\"(max-width: 1115px) 100vw, 1115px\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe 1 \u00a02022\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u5f97\u4e3b<\/p>\n<ul>\n<li><b><\/b><strong><b>\u83b7\u5956\u7406\u7531<\/b><\/strong><\/li>\n<\/ul>\n<p>\u957f\u671f\u4ee5\u6765\uff0c\u836f\u7269\u5206\u5b50\u3001\u5148\u5bfc\u7269\u3001\u5019\u9009\u836f\u7269\u3001\u751f\u7269\u63a2\u9488\u3001\u5e94\u7528\u6750\u6599\u53ca\u5177\u6709\u7279\u6b8a\u529f\u80fd\u7684\u590d\u6742\u5206\u5b50\u5f15\u8d77\u4e86\u79d1\u5b66\u5bb6\u4eec\u7684\u5e7f\u6cdb\u7684\u7814\u7a76\u5174\u8da3\uff0c\u800c\u5176\u6784\u5efa\u8fc7\u7a0b\u5e38\u56e0\u8017\u65f6\u4ee5\u53ca\u6602\u8d35\u7684\u8bd5\u5242\u7b49\u95ee\u9898\u56f0\u6270\u7740\u4f17\u591a\u7684\u79d1\u5b66\u5bb6\u3002\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5bb6\u5f97\u4e3b\u4eec\u5f00\u53d1\u4e86\u4e00\u79cd\u65e8\u5728\u521b\u9020\u5404\u79cd\u529f\u80fd\u6027\u5206\u5b50\u7684\u57fa\u7840\u6280\u672f\uff0c\u5c06\u590d\u6742\u5206\u5b50\u7684\u5408\u6210\u7b80\u5355\u5316\uff0c\u751a\u81f3\u53ef\u901a\u8fc7\u76f4\u63a5\u7684\u8def\u7ebf\u6765\u6784\u5efa\u529f\u80fd\u5206\u5b50(\u56fe 2)\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43237 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7b4512c2529c230528e43d0c0b507222.png\" alt=\"\" width=\"1110\" height=\"580\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7b4512c2529c230528e43d0c0b507222.png 1110w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7b4512c2529c230528e43d0c0b507222-300x157.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7b4512c2529c230528e43d0c0b507222-680x355.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/7b4512c2529c230528e43d0c0b507222-768x401.png 768w\" sizes=\"(max-width: 1110px) 100vw, 1110px\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe 2 \u00a02022\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956(\u56fe\u7247\u6765\u6e90\u4e8e\u8bfa\u5956\u7f51\u7ad9)<\/p>\n<p><a href=\"\/\/www.gsbet888.com\/chemists\/2020\/06\/morten-p-meldal.html\"><u>Morten Meldal<\/u><\/a>\u548c\u00a0<a href=\"\/\/www.gsbet888.com\/chemists\/2014\/06\/%e5%8d%a1%e5%b0%94%c2%b7%e5%b7%b4%e9%87%8c%c2%b7%e5%a4%8f%e6%99%ae%e8%8e%b1%e6%96%af-karl-barry-sharpless.html\"><u>K. Barry Sharpless<\/u><\/a>\u5f00\u53d1\u4e86\u4e00\u79cd\u57fa\u7840\u6280\u672f\u2014\u70b9\u51fb\u5316\u5b66(<a href=\"\/\/www.gsbet888.com\/reactions\/2019\/01\/%e7%82%b9%e5%87%bb%e5%8c%96%e5%ad%a6-click-chemistry.html\"><u>Click chemistry<\/u><\/a>)\uff0c\u4f7f\u5f97\u5404\u79cd\u590d\u6742\u529f\u80fd\u6027\u5206\u5b50(\u836f\u7269\u5019\u9009\u5316\u5408\u7269\uff0c\u751f\u7269\u63a2\u9488\uff0c\u5e94\u7528\u6750\u6599\u7b49)\u76f4\u63a5\u5408\u6210\u6210\u4e3a\u53ef\u80fd\u3002<a href=\"\/\/www.gsbet888.com\/chemists\/2018\/02\/carolyne-r-bertozzi.html\"><u>Carolyn R. Bertozzi<\/u><\/a>\u00a0\u5c06\u70b9\u51fb\u5316\u5b66\u63d0\u5347\u5230\u4e86\u4e00\u4e2a\u65b0\u7684\u7ef4\u5ea6\uff0c\u5c06\u5176\u7528\u4e8e\u751f\u7269\u4f53\u4e2d\u6765\u7814\u7a76\u7ec6\u80de\u8868\u9762\u7684\u7cd6\u94fe\uff0c\u5e76\u5728\u764c\u75c7\uff0c\u4f20\u67d3\u75c5\uff0c\u708e\u75c7\u6027\u75be\u75c5\u7b49\u65b9\u9762\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u5e76\u4e14\u7740\u91cd\u9610\u4e9b\u7cd6\u94fe\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u7684\u529f\u80fd\u7684\u5316\u5b66\u751f\u7269\u5b66\u7814\u7a76\u3002<\/p>\n<ul>\n<li><b><\/b><strong><b>\u6df1\u5ea6\u89e3\u6790<\/b><\/strong><\/li>\n<\/ul>\n<p>\u5927\u7ea6\u57282000\u5e74\uff0c<strong><b>K. Barry Sharpless<\/b><\/strong>\u63d0\u51fa\u4e86 \u201c\u70b9\u51fb\u5316\u5b66(<a href=\"\/\/www.gsbet888.com\/reactions\/2019\/01\/%e7%82%b9%e5%87%bb%e5%8c%96%e5%ad%a6-click-chemistry.html\"><u>Click chemistry<\/u><\/a>)\u201d\u7684\u6982\u5ff5\uff0c\u5176\u70b9\u51fb\u6309\u952e\u4e00\u822c\u7b80\u5355\u8fc5\u901f\uff0c\u901a\u8fc7\u9ad8\u5b98\u80fd\u56e2\u9009\u62e9\u6027\u3001\u9ad8\u6548\u7684\u53cd\u5e94\u83b7\u5f97\u5404\u79cd\u751f\u7269\u591a\u6837\u6027\u5206\u5b50\uff0c\u5982\u836f\u7269\u5019\u9009\u5316\u5408\u7269\uff0c\u751f\u7269\u63a2\u9488\uff0c\u5e94\u7528\u6750\u6599\u7b49\u3002<\/p>\n<p>\u4e0d\u4e45\u4e4b\u540e\uff0c<strong><b>Morten Meldal<\/b><\/strong>\u548c <strong><b>K. Barry Sharpless<\/b><\/strong>\u4e8c\u4eba\u72ec\u7acb\u7684\u62a5\u9053\u4e86\u5982\u4eca\u7684\u70b9\u51fb\u5316\u5b66\u7684\u7687\u51a0\u4e0a\u7684\u660e\u73e0\uff1a\u94dc\u50ac\u5316\u53e0\u6c2e\u5316\u7269\u4e0e\u7094\u70c3\u7684\u73af\u52a0\u6210(\u56fe 3)\u3002\u8be5\u65b9\u6cd5\u662f\u4e00\u79cd\u4f18\u96c5\u800c\u9ad8\u6548\u7684\u5316\u5b66\u53cd\u5e94\uff0c\u5e76\u5728\u836f\u7269\u5f00\u53d1\u3001DNA\u56fe\u8c31\u7ed8\u5236\u4ee5\u53ca\u751f\u7269\u63a2\u9488\u548c\u5176\u4ed6\u529f\u80fd\u6750\u6599\u7684\u5408\u6210\u4e2d\u5f97\u5230\u4e86\u5e7f\u6cdb\u7684\u5e94\u7528\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43238 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/45fb44102108640785ea52ff2021453d.png\" alt=\"\" width=\"925\" height=\"1259\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/45fb44102108640785ea52ff2021453d.png 925w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/45fb44102108640785ea52ff2021453d-220x300.png 220w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/45fb44102108640785ea52ff2021453d-680x926.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/45fb44102108640785ea52ff2021453d-768x1045.png 768w\" sizes=\"(max-width: 925px) 100vw, 925px\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe 3 \u00a0Click chemistry\u00a0(\u56fe\u7247\u6765\u6e90\u4e8e\u8bfa\u5956\u7f51\u7ad9)<\/p>\n<p><strong><b>Carolyn R. Bertozzi<\/b><\/strong>\u00a0\u5c06\u70b9\u51fb\u5316\u5b66\u63d0\u5347\u5230\u4e86\u4e00\u4e2a\u65b0\u7684\u7ef4\u5ea6\uff0c\u5c06\u5176\u7528\u4e8e\u751f\u7269\u4f53\u4e2d\u6765\u7814\u7a76\u7ec6\u80de\u8868\u9762\u7684\u7cd6\u94fe\uff0c\u5e76\u5728\u764c\u75c7\uff0c\u4f20\u67d3\u75c5\uff0c\u708e\u75c7\u6027\u75be\u75c5\u7b49\u65b9\u9762\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u00a0(\u56fe 4)\uff0c\u5e76\u4e14\u7740\u91cd\u9610\u4e9b\u7cd6\u94fe\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u7684\u529f\u80fd\u7684\u5316\u5b66\u751f\u7269\u5b66\u7814\u7a76\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43239 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/b055659b5babe406840e1a10a62c4fef.png\" alt=\"\" width=\"974\" height=\"1176\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/b055659b5babe406840e1a10a62c4fef.png 974w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/b055659b5babe406840e1a10a62c4fef-248x300.png 248w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/b055659b5babe406840e1a10a62c4fef-680x821.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/b055659b5babe406840e1a10a62c4fef-768x927.png 768w\" sizes=\"(max-width: 974px) 100vw, 974px\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe\u00a04 \u751f\u7269\u6b63\u4ea4\u5316\u5b66\u7684\u53d1\u5c55\u00a0(\u56fe\u7247\u6765\u6e90\u4e8e\u8bfa\u5956\u7f51\u7ad9)<\/p>\n<p>\u70b9\u51fb\u5316\u5b66\u548c\u751f\u7269\u6b63\u4ea4\u53cd\u5e94\u5c06\u5316\u5b66\u5e26\u5165\u4e86\u201c\u529f\u80fd\u4e3b\u4e49\u201d\u65f6\u4ee3\uff0c\u5e76\u7ed9\u4eba\u7c7b\u5e26\u6765\u4e86\u5de8\u5927\u7684\u5229\u76ca\u3002<\/p>\n<ul>\n<li><b><\/b><strong><b>\u76f8\u5173\u94fe\u63a5<\/b><\/strong><\/li>\n<\/ul>\n<p><a href=\"\/\/www.gsbet888.com\/chemists\/2022\/09\/%e5%8c%96%e5%ad%a6%e7%a9%ba%e9%97%b4%e8%af%ba%e8%b4%9d%e5%b0%94%e5%8c%96%e5%ad%a6%e5%a5%96%e5%be%97%e4%b8%bb%e9%a2%84%e6%b5%8b%e3%80%902022%e5%b9%b4%e5%ba%a6%e3%80%91.html\"><u>\u5316\u5b66\u7a7a\u95f4\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u5f97\u4e3b\u9884\u6d4b\u3010<\/u><u>2022\u5e74\u5ea6\u3011<\/u><\/a><\/p>\n<p><a href=\"\/\/www.gsbet888.com\/chemnews\/2021\/10\/2021%e5%b9%b4%e8%af%ba%e8%b4%9d%e5%b0%94%e5%8c%96%e5%ad%a6%e5%a5%96-%e8%a7%a3%e8%af%bb.html\"><u>2021\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956 \u89e3\u8bfb<\/u><\/a><\/p>\n<p><a href=\"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2020\/11\/%e8%bf%9f%e5%88%b0%e7%9a%84%e8%af%ba%e8%b4%9d%e5%b0%94%e5%a5%96-%e5%9f%ba%e5%9b%a0%e9%ad%94%e5%89%aacrispr%e6%8a%80%e6%9c%af-2020%e8%af%ba%e8%b4%9d%e5%b0%94.html\"><u>\u8fdf\u5230\u7684\u8bfa\u8d1d\u5c14\u5956\u2014\u2014\u201c\u57fa\u56e0\u9b54\u526a\u201d<\/u><u>CRISPR\u6280\u672f \u20132020\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u89e3\u6790<\/u><\/a><\/p>\n<p><a href=\"\/\/www.gsbet888.com\/reactions\/2019\/01\/%e7%82%b9%e5%87%bb%e5%8c%96%e5%ad%a6-click-chemistry.html\"><u>\u70b9\u51fb\u5316\u5b66<\/u><u>\u00a0\/ Click chemistry<\/u><\/a><\/p>\n<p><a href=\"\/\/www.gsbet888.com\/reactions\/2016\/04\/post-9339.html\"><u>\u70b9\u51fb\u5316\u5b66\uff08<\/u><u>Huisgen Cycloaddition\uff09<\/u><\/a><\/p>\n<p><a href=\"\/\/www.gsbet888.com\/chemists\/2020\/06\/morten-p-meldal.html\"><u>Morten Meldal<\/u><\/a><\/p>\n<p><a href=\"\/\/www.gsbet888.com\/chemists\/2014\/06\/%e5%8d%a1%e5%b0%94%c2%b7%e5%b7%b4%e9%87%8c%c2%b7%e5%a4%8f%e6%99%ae%e8%8e%b1%e6%96%af-karl-barry-sharpless.html\"><u>K. Barry Sharpless<\/u><\/a><\/p>\n<p><a href=\"\/\/www.gsbet888.com\/chemists\/2018\/02\/carolyne-r-bertozzi.html\"><u>Carolyn R. Bertozzi<\/u><\/a><\/p>\n<p><strong><b>\u00a0<\/b><\/strong><\/p>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a\u00a0 \u5bfc\u8bfb\uff1a \u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u4e8e10\u67085\u65e517\u70b945\u5206\u5728\u745e\u5178\u9996\u90fd\u65af\u5fb7\u54e5\u5c14\u6469\u745e\u5178\u7687\u5bb6\u79d1\u5b66\u9662\u63ed\u6653\uff0c\u8bfa\u8d1d\u5c14\u5956\u59d4\u5458\u4f1a\u5c06\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u6388\u4e88\u7f8e\u56fd\u79d1\u5b66\u5bb6Carolyn R. Bertozzi\u3001\u4e39\u9ea6\u79d1\u5b66\u5bb6Morten Meldal\u548c\u7f8e\u56fd\u79d1\u5b66\u5bb6K. Barry Sharpless\uff0c\u83b7\u5956\u7406\u7531\uff1a\u56e0\u201c\u53d1\u5c55\u70b9\u51fb\u5316\u5b66\u548c\u751f\u7269\u6b63\u4ea4\u5316\u5b66&#8221;\u6240\u505a\u51fa\u7684\u7814\u7a76\u8d21\u732e\uff08for the development of click chemistry and bioorthogonal chemistry\uff09\u201d\uff0c\u65e8\u5728\u5c06\u56f0\u96be\u7684\u8fc7\u7a0b\u53d8\u5f97\u66f4\u52a0\u5bb9\u6613(\u56fe 1)\u3002 \u56fe 1 \u00a02022\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u5f97\u4e3b \u83b7\u5956\u7406\u7531 \u957f\u671f\u4ee5\u6765\uff0c\u836f\u7269\u5206\u5b50\u3001\u5148\u5bfc\u7269\u3001\u5019\u9009\u836f\u7269\u3001\u751f\u7269\u63a2\u9488\u3001\u5e94\u7528\u6750\u6599\u53ca\u5177\u6709\u7279\u6b8a\u529f\u80fd\u7684\u590d\u6742\u5206\u5b50\u5f15\u8d77\u4e86\u79d1\u5b66\u5bb6\u4eec\u7684\u5e7f\u6cdb\u7684\u7814\u7a76\u5174\u8da3\uff0c\u800c\u5176\u6784\u5efa\u8fc7\u7a0b\u5e38\u56e0\u8017\u65f6\u4ee5\u53ca\u6602\u8d35\u7684\u8bd5\u5242\u7b49\u95ee\u9898\u56f0\u6270\u7740\u4f17\u591a\u7684\u79d1\u5b66\u5bb6\u3002\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5bb6\u5f97\u4e3b\u4eec\u5f00\u53d1\u4e86\u4e00\u79cd\u65e8\u5728\u521b\u9020\u5404\u79cd\u529f\u80fd\u6027\u5206\u5b50\u7684\u57fa\u7840\u6280\u672f\uff0c\u5c06\u590d\u6742\u5206\u5b50\u7684\u5408\u6210\u7b80\u5355\u5316\uff0c\u751a\u81f3\u53ef\u901a\u8fc7\u76f4\u63a5\u7684\u8def\u7ebf\u6765\u6784\u5efa\u529f\u80fd\u5206\u5b50(\u56fe 2)\u3002 &nbsp; \u56fe 2 \u00a02022\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956(\u56fe\u7247\u6765\u6e90\u4e8e\u8bfa\u5956\u7f51\u7ad9) Morten Meldal\u548c\u00a0K. Barry Sharpless\u5f00\u53d1\u4e86\u4e00\u79cd\u57fa\u7840\u6280\u672f\u2014\u70b9\u51fb\u5316\u5b66(Click chemistry)\uff0c\u4f7f\u5f97\u5404\u79cd\u590d\u6742\u529f\u80fd\u6027\u5206\u5b50(\u836f\u7269\u5019\u9009\u5316\u5408\u7269\uff0c\u751f\u7269\u63a2\u9488\uff0c\u5e94\u7528\u6750\u6599\u7b49)\u76f4\u63a5\u5408\u6210\u6210\u4e3a\u53ef\u80fd\u3002Carolyn R. Bertozzi\u00a0\u5c06\u70b9\u51fb\u5316\u5b66\u63d0\u5347\u5230\u4e86\u4e00\u4e2a\u65b0\u7684\u7ef4\u5ea6\uff0c\u5c06\u5176\u7528\u4e8e\u751f\u7269\u4f53\u4e2d\u6765\u7814\u7a76\u7ec6\u80de\u8868\u9762\u7684\u7cd6\u94fe\uff0c\u5e76\u5728\u764c\u75c7\uff0c\u4f20\u67d3\u75c5\uff0c\u708e\u75c7\u6027\u75be\u75c5\u7b49\u65b9\u9762\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u5e76\u4e14\u7740\u91cd\u9610\u4e9b\u7cd6\u94fe\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u7684\u529f\u80fd\u7684\u5316\u5b66\u751f\u7269\u5b66\u7814\u7a76\u3002 \u6df1\u5ea6\u89e3\u6790 \u5927\u7ea6\u57282000\u5e74\uff0cK. Barry Sharpless\u63d0\u51fa\u4e86 \u201c\u70b9\u51fb\u5316\u5b66(Click chemistry)\u201d\u7684\u6982\u5ff5\uff0c\u5176\u70b9\u51fb\u6309\u952e\u4e00\u822c\u7b80\u5355\u8fc5\u901f\uff0c\u901a\u8fc7\u9ad8\u5b98\u80fd\u56e2\u9009\u62e9\u6027\u3001\u9ad8\u6548\u7684\u53cd\u5e94\u83b7\u5f97\u5404\u79cd\u751f\u7269\u591a\u6837\u6027\u5206\u5b50\uff0c\u5982\u836f\u7269\u5019\u9009\u5316\u5408\u7269\uff0c\u751f\u7269\u63a2\u9488\uff0c\u5e94\u7528\u6750\u6599\u7b49\u3002 \u4e0d\u4e45\u4e4b\u540e\uff0cMorten Meldal\u548c K. Barry Sharpless\u4e8c\u4eba\u72ec\u7acb\u7684\u62a5\u9053\u4e86\u5982\u4eca\u7684\u70b9\u51fb\u5316\u5b66\u7684\u7687\u51a0\u4e0a\u7684\u660e\u73e0\uff1a\u94dc\u50ac\u5316\u53e0\u6c2e\u5316\u7269\u4e0e\u7094\u70c3\u7684\u73af\u52a0\u6210(\u56fe 3)\u3002\u8be5\u65b9\u6cd5\u662f\u4e00\u79cd\u4f18\u96c5\u800c\u9ad8\u6548\u7684\u5316\u5b66\u53cd\u5e94\uff0c\u5e76\u5728\u836f\u7269\u5f00\u53d1\u3001DNA\u56fe\u8c31\u7ed8\u5236\u4ee5\u53ca\u751f\u7269\u63a2\u9488\u548c\u5176\u4ed6\u529f\u80fd\u6750\u6599\u7684\u5408\u6210\u4e2d\u5f97\u5230\u4e86\u5e7f\u6cdb\u7684\u5e94\u7528\u3002 \u56fe 3 \u00a0Click chemistry\u00a0(\u56fe\u7247\u6765\u6e90\u4e8e\u8bfa\u5956\u7f51\u7ad9) Carolyn R. Bertozzi\u00a0\u5c06\u70b9\u51fb\u5316\u5b66\u63d0\u5347\u5230\u4e86\u4e00\u4e2a\u65b0\u7684\u7ef4\u5ea6\uff0c\u5c06\u5176\u7528\u4e8e\u751f\u7269\u4f53\u4e2d\u6765\u7814\u7a76\u7ec6\u80de\u8868\u9762\u7684\u7cd6\u94fe\uff0c\u5e76\u5728\u764c\u75c7\uff0c\u4f20\u67d3\u75c5\uff0c\u708e\u75c7\u6027\u75be\u75c5\u7b49\u65b9\u9762\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u00a0(\u56fe 4)\uff0c\u5e76\u4e14\u7740\u91cd\u9610\u4e9b\u7cd6\u94fe\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u7684\u529f\u80fd\u7684\u5316\u5b66\u751f\u7269\u5b66\u7814\u7a76\u3002 \u56fe\u00a04 \u751f\u7269\u6b63\u4ea4\u5316\u5b66\u7684\u53d1\u5c55\u00a0(\u56fe\u7247\u6765\u6e90\u4e8e\u8bfa\u5956\u7f51\u7ad9) \u70b9\u51fb\u5316\u5b66\u548c\u751f\u7269\u6b63\u4ea4\u53cd\u5e94\u5c06\u5316\u5b66\u5e26\u5165\u4e86\u201c\u529f\u80fd\u4e3b\u4e49\u201d\u65f6\u4ee3\uff0c\u5e76\u7ed9\u4eba\u7c7b\u5e26\u6765\u4e86\u5de8\u5927\u7684\u5229\u76ca\u3002 \u76f8\u5173\u94fe\u63a5 \u5316\u5b66\u7a7a\u95f4\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u5f97\u4e3b\u9884\u6d4b\u30102022\u5e74\u5ea6\u3011 2021\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956 \u89e3\u8bfb \u8fdf\u5230\u7684\u8bfa\u8d1d\u5c14\u5956\u2014\u2014\u201c\u57fa\u56e0\u9b54\u526a\u201dCRISPR\u6280\u672f \u20132020\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u89e3\u6790 \u70b9\u51fb\u5316\u5b66\u00a0\/ Click chemistry \u70b9\u51fb\u5316\u5b66\uff08Huisgen Cycloaddition\uff09 Morten Meldal K. Barry Sharpless Carolyn R. Bertozzi \u00a0 \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d &nbsp;","protected":false},"author":26,"featured_media":43235,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[212],"tags":[3919,247,3918,209],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/10\/589cb7b4b19a8cfc92771a403b92fa02.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-bfk","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/43234"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=43234"}],"version-history":[{"count":1,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/43234\/revisions"}],"predecessor-version":[{"id":43240,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/43234\/revisions\/43240"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/43235"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=43234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=43234"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=43234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}