{"id":43689,"date":"2022-11-17T08:00:02","date_gmt":"2022-11-17T00:00:02","guid":{"rendered":"\/\/www.gsbet888.com\/?p=43689"},"modified":"2022-11-27T16:24:01","modified_gmt":"2022-11-27T08:24:01","slug":"%e5%8f%a0%e6%b0%ae%e5%8c%96%e7%89%a9%e7%9a%84%e5%a4%84%e7%90%86","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/chemlife\/2022\/11\/%e5%8f%a0%e6%b0%ae%e5%8c%96%e7%89%a9%e7%9a%84%e5%a4%84%e7%90%86.html","title":{"rendered":"\u53e0\u6c2e\u5316\u7269\u7684\u5904\u7406"},"content":{"rendered":"<p>\u8bd1\u81eaChem-Station\u7f51\u7ad9\u65e5\u672c\u7248 \u539f\u6587\u94fe\u63a5\uff1a<a href=\"https:\/\/www.chem-station.com\/blog\/2022\/10\/azide.html\"><u>\u3010\u3044\u307e\u3055\u3089\u805e\u3051\u306a\u3044\uff1f\u3011\u30a2\u30b8\u30c9\u306e\u53d6\u6271\u3044\u3092\u5b66\u3093\u3067\u304a\u3053\u3046\uff01<\/u><\/a><\/p>\n<p>\u7ffb\u8bd1\uff1a\u70b8\u9e21<\/p>\n<p><strong><b>\u53e0\u6c2e\u5316\u7269<\/b><\/strong>\u4e0e\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u5173\u7cfb\u5341\u5206\u5bc6\u5207\u3002\u53e0\u6c2e\u5316\u7269\u4e0d\u4ec5\u88ab\u5e94\u7528\u4e8e\u70b9\u51fb\u5316\u5b66\uff0c\u8fd8\u5728\u7b80\u4fbf\u5bfc\u5165\u6c28\u57fa\u4e0a\u626e\u6f14\u7740\u4e0d\u53ef\u6216\u7f3a\u7684\u89d2\u8272\uff0c\u53e0\u6c2e\u5316\u7269\u7684\u4f7f\u7528\u9891\u7387\u8d8a\u6765\u8d8a\u9ad8\u4e86\u3002<\/p>\n<p>\u56e0\u4e3a\u53e0\u6c2e\u5316\u5b66\u7684\u7528\u5904\u6781\u5927\uff0c\u6240\u4ee5\u5404\u79cd\u5404\u6837\u65b0\u578b\u7684\u5173\u4e8e\u53e0\u6c2e\u57fa\u5bfc\u5165\u7684\u7814\u7a76\u4e5f\u65e5\u6e10\u6d3b\u8dc3\u3002\u6700\u8fd1\u62a5\u5bfc\u8f83\u591a\u7684\u6709\u501f\u52a9\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u5242\u7684\u5149\u53cd\u5e94\u30fb\u7535\u89e3\u53cd\u5e94\u3002<\/p>\n<p>\u80af\u5b9a\u4f1a\u6709\u201c<strong><b>\u53e0\u6c2e\u5316\u7269\u8fd9\u4e48\u5371\u9669\u7684\u4e1c\u897f\uff0c\u65b0\u5f00\u53d1\u7684\u53cd\u5e94\u6761\u4ef6\u771f\u7684\u80fd\u5b89\u5168\u5b9e\u8df5\u5417\uff1f\u7528\u65b0\u5f00\u53d1\u7684\u53cd\u5e94\u6761\u4ef6\u6295\u53cd\u5e94\u9700\u8981\u4e30\u5bcc\u7684\u5316\u5b66\u53cd\u5e94\u77e5\u8bc6\u5417\uff1f<\/b><\/strong>\u201d\u8fd9\u6837\u7684\u5fe7\u8651\u548c\u7591\u95ee\u3002\u8fd9\u6837\u7684\u5fe7\u8651\u5e76\u975e\u7a7a\u7a74\u6765\u98ce\uff0c\u53e0\u6c2e\u5316\u7269\u7684\u6d3b\u7528\u9886\u57df\u2014\u2014\u751f\u7269\u5316\u5b66\u548c\u65b0\u836f\u7814\u53d1\uff0c\u8fd9\u4e9b\u9886\u57df\u7684\u7814\u7a76\u8005\u5927\u591a\u90fd\u4e0d\u662f\u4e13\u95e8\u7684\u6709\u673a\u5408\u6210\u4e13\u5bb6\uff0c\u751a\u81f3\u7ecf\u9a8c\u5c1a\u6d45\u7684\u5b66\u751f\u4e5f\u6709\u3002<\/p>\n<p>\u8fd9\u4e9b\u5fe7\u8651\u771f\u7684\u6709\u5fc5\u8981\u5417\uff1fJournal of Organic Chemistry\u6742\u5fd7\u4eca\u5e74\u6709\u4e00\u7bc7\u5173\u4e8e<strong><b>\u53e0\u6c2e\u5316\u7269\u7684\u5371\u9669\u6027\u7684\u6587\u7ae0<\/b><\/strong>\u3002\u6587\u7ae0\u5185\u5bb9\u5f88\u57fa\u7840\u4e14\u603b\u7ed3\u7684\u5f88\u5230\u4f4d\uff0c\u662f\u5b9e\u9a8c\u5ba4\u5b89\u5168\u6559\u80b2\u7684\u7edd\u4f73\u6559\u6750\u3002\u4eca\u5929\u8ba9\u6211\u4eec\u6765\u7b80\u8981\u5b66\u4e60\u4e00\u4e0b\u5427\u3002<\/p>\n<blockquote><p>\u201cHow Dangerous Is Too Dangerous? A Perspective on Azide Chemistry\u201d<br \/>\nTreitler, D. S.*; Leung, S.\u00a0\u00a0J. Org. Chem.<strong><b>\u00a02022<\/b><\/strong>,\u00a087, 11293\u201311295. doi:<a href=\"https:\/\/doi.org\/10.1021\/acs.joc.2c01402\">10.1021\/acs.joc.2c01402<\/a><\/p><\/blockquote>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-43690\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/1668154716290-300x54.png\" alt=\"\" width=\"277\" height=\"50\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/1668154716290-300x54.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/1668154716290.png 341w\" sizes=\"(max-width: 277px) 100vw, 277px\" \/><\/p>\n<p>\u6700\u5e38\u89c1\u4e5f\u662f\u6700\u4fbf\u5b9c\u7684\u53e0\u6c2e\u57fa\u56e2\u6765\u6e90\u662f<strong><b>\u53e0\u6c2e\u5316\u94a0<\/b><\/strong><strong><b>\uff08NaN<sub>3<\/sub><\/b><\/strong><strong><b>\uff09<\/b><\/strong>\uff0c\u4f7f\u7528\u65f6\u9700\u8981\u6ce8\u610f\u4ee5\u4e0b3\u70b9\u3002\u4e0b\u9762\u8ba9\u6211\u4eec\u4f9d\u6b21\u6765\u770b\u3002<\/p>\n<ol>\n<li><b><\/b><strong><b>\u907f\u514d\u66b4\u9732\u5728\u9178\u4e2d<\/b><\/strong><\/li>\n<li><b><\/b><strong><b>\u907f\u514d\u66b4\u9732\u5728\u8fc7\u6e21\u91d1\u5c5e\u4e2d<\/b><\/strong><\/li>\n<li><b><\/b><strong><b>\u907f\u514d\u63a5\u89e6\u5364\u7d20\u6eb6\u5242<\/b><\/strong><\/li>\n<\/ol>\n<p><b><\/b><strong><b>1. \u907f\u514d\u66b4\u9732\u5728\u9178\u4e2d<\/b><\/strong><\/p>\n<p>\u53e0\u6c2e\u5316\u94a0\u548c\u9178\u6df7\u5408\u4f1a\u4ea7\u751f<span style=\"color: #ff0000;\"><strong><b>\u53e0\u6c2e\u9178\uff08<\/b><\/strong><strong><b>hydrazoic acid, HN<\/b><\/strong><sub><strong><b>3<\/b><\/strong><\/sub><strong><b>\uff09<\/b><\/strong><\/span>\u3002\u53e0\u6c2e\u9178\u4e0d\u4ec5\u5177\u6709<strong><b>\u6781\u5f3a\u7684\u6bd2\u6027<\/b><\/strong>\uff08\u5c0f\u9f20LD50=22 mg\/kg\uff09\uff0c\u8fd8\u62e5\u6709\u6bd4<a href=\"https:\/\/ja.wikipedia.org\/wiki\/%E3%83%88%E3%83%AA%E3%83%8B%E3%83%88%E3%83%AD%E3%83%88%E3%83%AB%E3%82%A8%E3%83%B3\"><u>TNT<\/u><\/a>\u8fd8\u5f3a\u7684<strong><b>\u7206\u70b8\u6027<\/b><\/strong>\uff0c\u662f\u5341\u5206\u4ee5\u53ca\u6781\u5176\u5371\u9669\u7684\u5316\u5408\u7269\u3002\u867d\u7136\u6bd2\u6027\u53ef\u4ee5\u901a\u8fc7\u7a00\u91ca\u51cf\u8f7b\uff0c\u4f46\u5371\u9669\u6027\u4e0d\u4f1a\u6709\u6240\u4e0b\u964d\u3002\u542b\u6709\u8d85\u8fc710%HN<sub>3<\/sub>\u7684\u6c14\u6001\u6c2e\u6c14\u6216\u800520wt%\uff08\u6b63\u786e\u6570\u503c\u8fd8\u672a\u5b9a\uff09\u4ee5\u4e0a\u7684HN<sub>3<\/sub>\u6c34\u6eb6\u6db2\u5c31\u5177\u5907\u7206\u70b8\u7684\u53ef\u80fd\u6027\u3002<\/p>\n<p>HN<sub>3<\/sub>\u7684\u6cb8\u70b9\u5f88\u4f4e\uff08\u53ea\u6709\u7ea636\u2103\uff09\uff0c\u5373\u4f7f\u662f\u7a00\u6eb6\u6db2\u4e5f\u5f88\u5bb9\u6613\u84b8\u53d1\u30fb\u518d\u51dd\u7ed3\u53d8\u6210\u6d53\u7f29\u6eb6\u6db2\uff08\u4e0b\u56fe\uff09\u3002\u53d1\u751f\u7206\u70b8\u751a\u81f3\u4e0d\u9700\u8981\u6c27\u6c14\u548c\u706b\u6e90\uff0c\u53ea\u9700\u8981\u8f7b\u5fae\u7684\u6469\u64e6\u548c\u649e\u51fb\u5c31\u53ef\u4ee5\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43694 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/3ca3c88143632dccb34cef1496d1f409.png\" alt=\"\" width=\"608\" height=\"664\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/3ca3c88143632dccb34cef1496d1f409.png 608w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/3ca3c88143632dccb34cef1496d1f409-275x300.png 275w\" sizes=\"(max-width: 608px) 100vw, 608px\" \/><\/p>\n<p style=\"text-align: center;\"><em><i>HN<\/i><\/em><sub><em><i>3<\/i><\/em><\/sub><em><i>\u7684<\/i><\/em><em><i>2.0wt%<\/i><\/em><em><i>\u6c34\u6eb6\u6db2\uff0c25<\/i><\/em><em><i>\u00a0\u2103<\/i><\/em><em><i>\u4e0b\uff0c\u53ef\u4ee5\u4ece\u70e7\u74f6\u58c1\u9762\u4e0a\u770b\u5230\u6eb6\u6db2\u5728\u84b8\u53d1\u6d53\u7f29\uff0c\u7ed3\u679c\u4f1a\u5f62\u6210<\/i><\/em><em><i>60wt\uff05<\/i><\/em><em><i>\u7684\u6c34\u6eb6\u6db2\uff08\u56fe\u7247\u6765\u81ea\u539f\u8bba\u6587\uff09<\/i><\/em><\/p>\n<p>HN<sub>3<\/sub>\u7684\u7a00\u6eb6\u6db2\u8981\u7528<strong><b>\u4f4e\u6cb8\u70b9\u6eb6\u5242\uff08\u4e59\u919a\u6216\u6b63\u620a\u70f7\uff09<\/b><\/strong><strong><b>\u505a\u6eb6\u5242<\/b><\/strong><strong><b>\uff0c\u4e0d\u65ad\u7a00\u91ca\u6325\u53d1\u51fa\u6765\u7684\u84b8\u6c14\u548c\u51dd\u7ed3\u7269<\/b><\/strong>\u662f\u4fdd\u5b58HN<sub>3<\/sub>\u6eb6\u6db2\u7684\u6700\u597d\u529e\u6cd5\uff08\u6709\u8ba1\u7b97\u8bc1\u660e\u8fd9\u79cd\u65b9\u6cd5\u80fd\u4f7f\u6d53\u5ea6\u7ef4\u6301\u5728\u5b89\u5168\u6d53\u5ea6\u4ee5\u4e0b\uff09\uff0c\u5728\u6709HN<sub>3<\/sub>\u751f\u6210\u7684\u53cd\u5e94\u4e2d\uff0c\u4e3a\u4e86\u9632\u6b62\u51dd\u7ed3\u9700\u8981<strong><b>\u4e0d\u95f4\u65ad\u5730\u901a\u5165\u6c2e\u6c14\u5e76\u8ba9\u53cd\u5e94\u88c5\u7f6e\u7684\u6e29\u5ea6\u7ef4\u6301\u572837\u2103\u4ee5\u4e0a<\/b><\/strong>\u3002<\/p>\n<p><b><\/b><strong><b>2. \u907f\u514d\u66b4\u9732\u5728\u8fc7\u6e21\u91d1\u5c5e\u4e2d<\/b><\/strong><\/p>\n<p>\u53e0\u6c2e\u5316\u94dc\uff08I\uff09\/\u94dc\uff08II\uff09\u4ee5\u53ca\u7c7b\u4f3c\u7269\u7684\u6df7\u5408\u7269\u5f15\u8d77\u7684\u7206\u70b8\u4e8b\u6545\u4e0d\u4e0b10\u4f59\u8d77\uff0c\u81f3\u5c11\u9020\u6210\u4e8616\u4eba\u7684\u6b7b\u4ea1\u3002\u7279\u522b\u662f\u7ed3\u6676\u6027\u56fa\u4f53\u7684\u53e0\u6c2e\u5316\u94dc(II)\uff0c\u5f88\u8f7b\u7684\u649e\u51fb\u4e5f\u80fd\u5728\u6c34\u4e2d\u5f15\u8d77\u6fc0\u70c8\u7684\u7206\u70b8\u3002\u5411\u542b\u6709\u65e0\u673a\u53e0\u6c2e\u5316\u7269\u6216\u8005HN<sub>3<\/sub>\u7684\u53cd\u5e94\u4e2d\u6dfb\u52a0\u8fc7\u6e21\u91d1\u5c5e\u662f\u4e00\u79cd\u5341\u5206\u5371\u9669\u7684\u884c\u4e3a\u3002\u5230\u73b0\u5728\u4e5f\u6ca1\u6709\u4ec0\u4e48\u53ef\u9760\u7684\u5411\u53e0\u6c2e\u5316\u7269\u4e2d\u52a0\u5165\u8fc7\u6e21\u91d1\u5c5e\u7684\u65b9\u6cd5\u3002Al, Ca, Ti, V, Cr, Mn, Co, Ni, Cu, Zn, Mo, Pd, Ag, Cd, Sn, Sb, Te, Ba, Pt, Au, Hg, Tl, Pb, Bi\u7b49\u91d1\u5c5e\u4f1a\u4e0e\u53e0\u6c2e\u5316\u7269\u751f\u6210\u53e0\u6c2e\u5316\u76d0\u3002\u5b9e\u9a8c\u5ba4\u79f0\u91cf\u53e0\u6c2e\u5316\u7269\u65f6<strong><b>\u4e0d\u80fd\u7528\u91d1\u5c5e\u836f\u5319\uff0c\u8981\u7528\u5851\u6599\u6216\u94c1\u6c1f\u9f99\u5236\u7684\u836f\u5319\u3002<\/b><\/strong><\/p>\n<p>\u8c03\u5236\u65e0\u673a\u53e0\u6c2e\u5316\u7269\u6216\u8005\u5de5\u4e1a\u5316\u751f\u4ea7\u53e0\u6c2e\u5316\u7269\u7684\u65f6\u5019\uff0c\u9700\u8981\u7279\u522b\u6ce8\u610f\u5c06\u91d1\u5c5e\u6392\u9664\u5728\u5916\u3002\u5305\u62ec\u53cd\u5e94\u7f38\u7684\u91d1\u5c5e\u96f6\u4ef6\uff0c\u91d1\u5c5e\u7684\u63a5\u5934\uff0c\u91d1\u5c5e\u7684\u70ed\u7535\u5bf9\uff0c\u91d1\u5c5e\u7684\u70ed\u7535\u5076\uff0c\u91d1\u5c5e\u94f2\u5b50\u6216\u91d1\u5c5e\u52fa\uff0c\u751a\u81f3\u5730\u9762\u6392\u6c34\u6c9f\u7684\u94dc\u5236\u7ba1\u9053\u90fd\u8981\u4e25\u683c\u4fdd\u62a4\u907f\u514d\u63a5\u89e6\u53e0\u6c2e\u5316\u7269\u3002<\/p>\n<p><b><\/b><strong><b>3. \u907f\u514d\u63a5\u89e6\u5364\u7d20\u6eb6\u5242<\/b><\/strong><\/p>\n<p>\u5c24\u5176\u8981\u907f\u514d\u63a5\u89e6\u4e8c\u6c2f\u7532\u70f7\u3002\u65e0\u673a\u53e0\u6c2e\u5316\u7269\u4e0e\u4e8c\u6c2f\u7532\u70f7\u63a5\u89e6\u4f1a\u751f\u6210\u7206\u70b8\u6027\u6781\u5f3a\u7684<span style=\"color: #ff0000;\"><strong><b>\u91cd\u6c2e\u7532\u70f7<\/b><\/strong><\/span>\u3002\u76f8\u5173\u7684\u7206\u70b8\u4e8b\u6545\u5c61\u89c1\u4e0d\u9c9c\u3002<\/p>\n<p>\u5728\u5316\u5b66\u5de5\u573a\u66fe\u7ecf\u53d1\u751f\u8fc7\u4e00\u8d77\u4e25\u91cd\u7684\u5b89\u5168\u4e8b\u6545\u3002\u4e0b\u56fe<strong><u><b>2<\/b><\/u><\/strong>\u2192<strong><u><b>3<\/b><\/u><\/strong>\u7684\u53e0\u6c2e\u57fa\u7684S<sub>N<\/sub>2\u53d6\u4ee3\u53cd\u5e94\u66fe\u7ecf\u5728\u540e\u5904\u7406\u65f6\u53d1\u751f\u8fc7\u7206\u70b8\u3002\u867d\u7136\u53cd\u5e94\u672c\u8eab\u7528\u7684\u662f\u5bf9\u53e0\u6c2e\u5316\u7269\u5b89\u5168\u7684DMF\uff0c\u4f46\u4e0a\u4e00\u6b65\u53cd\u5e94\u6b8b\u7559\u7684\u4e8c\u6c2f\u7532\u70f7\uff08DCM\uff09\u662f\u5f15\u8d77\u4e8b\u6545\u7684\u7f6a\u9b41\u7978\u9996\u3002<strong><u><b>1<\/b><\/u><\/strong>\u2192<strong><u><b>2<\/b><\/u><\/strong>\u7684\u53cd\u5e94\uff081kg\u89c4\u6a21\uff09\u7ed3\u675f\u540e\u867d\u7136\u84b8\u53d1\u4e86\u6eb6\u5242\u4f46\u662f\u6ca1\u6709\u5b8c\u5168\u9664\u5c3d\uff0c\u6b8b\u7559\u7684\u4e8c\u6c2f\u7532\u70f7\u5230\u4e86\u4e0b\u4e00\u6b65\u53cd\u5e94\u4e0eNaN3\u53cd\u5e94\u751f\u6210\u4e86\u91cd\u6c2e\u7532\u70f7\uff0c\u5728\u53cd\u5e94\u7ed3\u675f\u65f6\u6eb6\u5242\u88ab\u84b8\u53d1\u540e\u91cd\u6c2e\u7532\u70f7\u9ad8\u5ea6\u6d53\u7f29\u4ece\u800c\u5f15\u8d77\u5927\u7206\u70b8\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43695 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/17285261fc53d4b8b8e24c441b1625d3.png\" alt=\"\" width=\"1064\" height=\"179\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/17285261fc53d4b8b8e24c441b1625d3.png 1064w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/17285261fc53d4b8b8e24c441b1625d3-300x50.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/17285261fc53d4b8b8e24c441b1625d3-680x114.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/17285261fc53d4b8b8e24c441b1625d3-768x129.png 768w\" sizes=\"(max-width: 1064px) 100vw, 1064px\" \/><\/p>\n<p style=\"text-align: center;\"><em><i>\u5f15\u7528\uff1a<\/i><\/em><a href=\"https:\/\/doi.org\/10.1021\/op8000977\"><em><i>Org. Process Res. Dev.\u20022008,\u200212, 1285.<\/i><\/em><\/a><\/p>\n<p>\u9664\u4e86\u4f1a\u5728\u53cd\u5e94\u6eb6\u5242\u4e0a\u201c\u7ffb\u8f66\u201d\uff0c\u53cd\u5e94\u7ed3\u675f\u540e\u7684\u5904\u7406\u8fc7\u7a0b\u4e2d<strong><b>\u5206\u6db2\u6240\u7528\u7684\u8403\u53d6\u6eb6\u5242\u4e0d\u5c0f\u5fc3\u7528\u4e86\u4e8c\u6c2f\u7532\u70f7<\/b><\/strong>\u4e5f\u4f1a\u201c\u7ffb\u8f66\u201d\uff0c\u8fd9\u6837\u7684\u60e8\u6848\u5c61\u5c61\u53d1\u751f\u3002\u53e0\u6c2e\u53cd\u5e94\u5230\u5904\u90fd\u6f5c\u4f0f\u7740\u5371\u9669\uff0c\u6240\u4ee5\u8981\u683c\u5916\u6ce8\u610f\u548c\u5c0f\u5fc3\u3002<\/p>\n<p>\u4eca\u5929\u7684\u4e3b\u8981\u76ee\u7684\u662f\u5524\u8d77\u5404\u4f4d\u5b9e\u9a8c\u5ba4\u201c\u642c\u7816\u4eba\u201d\u5bf9\u5371\u9669\u7684\u65e0\u673a\u53e0\u6c2e\u5316\u7269\u7684\u8b66\u89c9\uff0c\u4f46\u4e0d\u8981\u5fd8\u4e86\u6709\u673a\u53e0\u6c2e\u5316\u7269\u4e5f\u4e00\u6837\u7684\u5371\u9669\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-43691\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/1668154716292.png\" alt=\"\" width=\"112\" height=\"52\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/1668154716292.png 123w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/1668154716292-120x57.png 120w\" sizes=\"(max-width: 112px) 100vw, 112px\" \/><\/p>\n<p>\u5728\u8bba\u6587\u7684\u6700\u540e\uff0c\u4f5c\u8005\u548c\u5ba1\u7a3f\u4eba\u603b\u7ed3\u9053\u201c\u4e00\u5b9a\u8981\u5341\u5206\u5bc6\u5207\u6ce8\u610f\u5b89\u5168\u95ee\u9898\u3002\u4e3a\u4e86\u4e0d\u8ba9\u60b2\u5267\u91cd\u6f14\uff0c\u4e00\u5b9a\u8981\u52aa\u529b\u63d0\u5347\u5e94\u5bf9\u5371\u9669\u72b6\u51b5\u7684\u77e5\u8bc6\u50a8\u5907\u201d\u3002\u65e0\u8bba\u662f\u591a\u5371\u9669\u7684\u8bd5\u5242\u53ea\u8981\u53d6\u7528\u5f97\u5f53\uff0c\u4e5f\u662f\u4e00\u628a\u5229\u5251\u3002\u5fc3\u4e2d\u77e5\u8bc6\u8db3\uff0c\u5b9e\u9a8c\u7a33\u5f53\u5f53\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-43692\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/1668154716297.png\" alt=\"\" width=\"91\" height=\"50\" \/><\/p>\n<p>\u5728\u7bc7\u8bba\u6587\u520a\u767b\u524d\uff0cJOC\u6742\u5fd7\u5c31\u6709\u4e00\u7bc7\u51fa\u81eaGazvoda\u7684\u6587\u7ae0\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-43696 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/f837b207373c0102788e90d54a5ca30f.png\" alt=\"\" width=\"800\" height=\"568\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/f837b207373c0102788e90d54a5ca30f.png 800w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/f837b207373c0102788e90d54a5ca30f-300x213.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/f837b207373c0102788e90d54a5ca30f-680x483.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2022\/11\/f837b207373c0102788e90d54a5ca30f-768x545.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p>\n<p style=\"text-align: center;\"><em><i>\u5f15\u7528\u81ea\u8bba\u6587<\/i><\/em><em><i>J. Org. Chem.\u20022022,\u200287, 4018<\/i><\/em><\/p>\n<p>\u4ece\u4e0a\u56fe\u770b\uff0c\u53e0\u6c2e\u5316\u94dc\uff08II\uff09\uff0bHN<sub>3<\/sub>\u662f\u6700\u597d\u7684\u6761\u4ef6\u3002\u5728\u8bba\u6587\u7684Conclusion\u90e8\u5206\u6709\u8fd9\u4e48\u4e00\u6bb5\u8bdd\uff1a<\/p>\n<p style=\"text-align: center;\">It is noteworthy that hydrazoic acid was recently used for the large-scale synthesis of an early aryltetrazole intermediate in the synthesis of a drug candidate, giving the developed method the potential for scaling-up.<\/p>\n<p>\u8be5\u7bc7\u8bba\u6587\u53d1\u8868\u540e\uff0c\u6709\u4e0d\u5c11\u6295\u8bc9\u610f\u89c1\u98de\u5230\u6742\u5fd7\u7f16\u8f91\u90e8\uff0c\u6307\u51fa\u8fd9\u7ed3\u8bba\u6709\u5b89\u5168\u9690\u60a3\u3002\u6700\u540e\u8bba\u6587\u7684\u4f5c\u8005\u4e0d\u5f97\u4e0d\u5728Addition &amp; Correction\u4e2d\u8865\u5145\u8bf4\u660e\u201c\u4f34\u968f\u6709NH<sub>3<\/sub>\u751f\u6210\u7684\u53cd\u5e94\u91cc\u4e0d\u5145\u5206\u8003\u8651\u6d53\u5ea6\u548c\u91d1\u5c5e\u6765\u6e90\u5c31\u63d0\u51fa\u52a0\u5927\u53cd\u5e94\u89c4\u6a21\uff0c\u8fd9\u662f\u5341\u5206\u4e0d\u7406\u667a\u7684\u201d<\/p>\n<p>\u4ece\u4e8b\u65b0\u53cd\u5e94\u5f00\u53d1\u7684\u8bfb\u8005\u4eec\uff0c\u8bf7\u8c28\u8bb0\u5343\u4e07\u4e0d\u8981\u88ab\u65b0\u53cd\u5e94\u7684\u6210\u5c31\u51b2\u660f\u5934\u8111\u800c\u5728\u8bba\u6587\u4e2d\u5199\u51fa\u4e00\u4e9b\u4e0d\u8d1f\u8d23\u4efb\u7684\u7ed3\u8bba\u3002<\/p>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/p>\n","protected":false},"excerpt":{"rendered":"\u8bd1\u81eaChem-Station\u7f51\u7ad9\u65e5\u672c\u7248 \u539f\u6587\u94fe\u63a5\uff1a\u3010\u3044\u307e\u3055\u3089\u805e\u3051\u306a\u3044\uff1f\u3011\u30a2\u30b8\u30c9\u306e\u53d6\u6271\u3044\u3092\u5b66\u3093\u3067\u304a\u3053\u3046\uff01 \u7ffb\u8bd1\uff1a\u70b8\u9e21 \u53e0\u6c2e\u5316\u7269\u4e0e\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u5173\u7cfb\u5341\u5206\u5bc6\u5207\u3002\u53e0\u6c2e\u5316\u7269\u4e0d\u4ec5\u88ab\u5e94\u7528\u4e8e\u70b9\u51fb\u5316\u5b66\uff0c\u8fd8\u5728\u7b80\u4fbf\u5bfc\u5165\u6c28\u57fa\u4e0a\u626e\u6f14\u7740\u4e0d\u53ef\u6216\u7f3a\u7684\u89d2\u8272\uff0c\u53e0\u6c2e\u5316\u7269\u7684\u4f7f\u7528\u9891\u7387\u8d8a\u6765\u8d8a\u9ad8\u4e86\u3002 \u56e0\u4e3a\u53e0\u6c2e\u5316\u5b66\u7684\u7528\u5904\u6781\u5927\uff0c\u6240\u4ee5\u5404\u79cd\u5404\u6837\u65b0\u578b\u7684\u5173\u4e8e\u53e0\u6c2e\u57fa\u5bfc\u5165\u7684\u7814\u7a76\u4e5f\u65e5\u6e10\u6d3b\u8dc3\u3002\u6700\u8fd1\u62a5\u5bfc\u8f83\u591a\u7684\u6709\u501f\u52a9\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u5242\u7684\u5149\u53cd\u5e94\u30fb\u7535\u89e3\u53cd\u5e94\u3002 \u80af\u5b9a\u4f1a\u6709\u201c\u53e0\u6c2e\u5316\u7269\u8fd9\u4e48\u5371\u9669\u7684\u4e1c\u897f\uff0c\u65b0\u5f00\u53d1\u7684\u53cd\u5e94\u6761\u4ef6\u771f\u7684\u80fd\u5b89\u5168\u5b9e\u8df5\u5417\uff1f\u7528\u65b0\u5f00\u53d1\u7684\u53cd\u5e94\u6761\u4ef6\u6295\u53cd\u5e94\u9700\u8981\u4e30\u5bcc\u7684\u5316\u5b66\u53cd\u5e94\u77e5\u8bc6\u5417\uff1f\u201d\u8fd9\u6837\u7684\u5fe7\u8651\u548c\u7591\u95ee\u3002\u8fd9\u6837\u7684\u5fe7\u8651\u5e76\u975e\u7a7a\u7a74\u6765\u98ce\uff0c\u53e0\u6c2e\u5316\u7269\u7684\u6d3b\u7528\u9886\u57df\u2014\u2014\u751f\u7269\u5316\u5b66\u548c\u65b0\u836f\u7814\u53d1\uff0c\u8fd9\u4e9b\u9886\u57df\u7684\u7814\u7a76\u8005\u5927\u591a\u90fd\u4e0d\u662f\u4e13\u95e8\u7684\u6709\u673a\u5408\u6210\u4e13\u5bb6\uff0c\u751a\u81f3\u7ecf\u9a8c\u5c1a\u6d45\u7684\u5b66\u751f\u4e5f\u6709\u3002 \u8fd9\u4e9b\u5fe7\u8651\u771f\u7684\u6709\u5fc5\u8981\u5417\uff1fJournal of Organic Chemistry\u6742\u5fd7\u4eca\u5e74\u6709\u4e00\u7bc7\u5173\u4e8e\u53e0\u6c2e\u5316\u7269\u7684\u5371\u9669\u6027\u7684\u6587\u7ae0\u3002\u6587\u7ae0\u5185\u5bb9\u5f88\u57fa\u7840\u4e14\u603b\u7ed3\u7684\u5f88\u5230\u4f4d\uff0c\u662f\u5b9e\u9a8c\u5ba4\u5b89\u5168\u6559\u80b2\u7684\u7edd\u4f73\u6559\u6750\u3002\u4eca\u5929\u8ba9\u6211\u4eec\u6765\u7b80\u8981\u5b66\u4e60\u4e00\u4e0b\u5427\u3002 \u201cHow Dangerous Is Too Dangerous? A Perspective on Azide Chemistry\u201d Treitler, D. S.*; Leung, S.\u00a0\u00a0J. Org. Chem.\u00a02022,\u00a087, 11293\u201311295. doi:10.1021\/acs.joc.2c01402 \u6700\u5e38\u89c1\u4e5f\u662f\u6700\u4fbf\u5b9c\u7684\u53e0\u6c2e\u57fa\u56e2\u6765\u6e90\u662f\u53e0\u6c2e\u5316\u94a0\uff08NaN3\uff09\uff0c\u4f7f\u7528\u65f6\u9700\u8981\u6ce8\u610f\u4ee5\u4e0b3\u70b9\u3002\u4e0b\u9762\u8ba9\u6211\u4eec\u4f9d\u6b21\u6765\u770b\u3002 \u907f\u514d\u66b4\u9732\u5728\u9178\u4e2d \u907f\u514d\u66b4\u9732\u5728\u8fc7\u6e21\u91d1\u5c5e\u4e2d \u907f\u514d\u63a5\u89e6\u5364\u7d20\u6eb6\u5242 1. \u907f\u514d\u66b4\u9732\u5728\u9178\u4e2d \u53e0\u6c2e\u5316\u94a0\u548c\u9178\u6df7\u5408\u4f1a\u4ea7\u751f\u53e0\u6c2e\u9178\uff08hydrazoic acid, HN3\uff09\u3002\u53e0\u6c2e\u9178\u4e0d\u4ec5\u5177\u6709\u6781\u5f3a\u7684\u6bd2\u6027\uff08\u5c0f\u9f20LD50=22 mg\/kg\uff09\uff0c\u8fd8\u62e5\u6709\u6bd4TNT\u8fd8\u5f3a\u7684\u7206\u70b8\u6027\uff0c\u662f\u5341\u5206\u4ee5\u53ca\u6781\u5176\u5371\u9669\u7684\u5316\u5408\u7269\u3002\u867d\u7136\u6bd2\u6027\u53ef\u4ee5\u901a\u8fc7\u7a00\u91ca\u51cf\u8f7b\uff0c\u4f46\u5371\u9669\u6027\u4e0d\u4f1a\u6709\u6240\u4e0b\u964d\u3002\u542b\u6709\u8d85\u8fc710%HN3\u7684\u6c14\u6001\u6c2e\u6c14\u6216\u800520wt%\uff08\u6b63\u786e\u6570\u503c\u8fd8\u672a\u5b9a\uff09\u4ee5\u4e0a\u7684HN3\u6c34\u6eb6\u6db2\u5c31\u5177\u5907\u7206\u70b8\u7684\u53ef\u80fd\u6027\u3002 HN3\u7684\u6cb8\u70b9\u5f88\u4f4e\uff08\u53ea\u6709\u7ea636\u2103\uff09\uff0c\u5373\u4f7f\u662f\u7a00\u6eb6\u6db2\u4e5f\u5f88\u5bb9\u6613\u84b8\u53d1\u30fb\u518d\u51dd\u7ed3\u53d8\u6210\u6d53\u7f29\u6eb6\u6db2\uff08\u4e0b\u56fe\uff09\u3002\u53d1\u751f\u7206\u70b8\u751a\u81f3\u4e0d\u9700\u8981\u6c27\u6c14\u548c\u706b\u6e90\uff0c\u53ea\u9700\u8981\u8f7b\u5fae\u7684\u6469\u64e6\u548c\u649e\u51fb\u5c31\u53ef\u4ee5\u3002 HN3\u76842.0wt%\u6c34\u6eb6\u6db2\uff0c25\u00a0\u2103\u4e0b\uff0c\u53ef\u4ee5\u4ece\u70e7\u74f6\u58c1\u9762\u4e0a\u770b\u5230\u6eb6\u6db2\u5728\u84b8\u53d1\u6d53\u7f29\uff0c\u7ed3\u679c\u4f1a\u5f62\u621060wt\uff05\u7684\u6c34\u6eb6\u6db2\uff08\u56fe\u7247\u6765\u81ea\u539f\u8bba\u6587\uff09 HN3\u7684\u7a00\u6eb6\u6db2\u8981\u7528\u4f4e\u6cb8\u70b9\u6eb6\u5242\uff08\u4e59\u919a\u6216\u6b63\u620a\u70f7\uff09\u505a\u6eb6\u5242\uff0c\u4e0d\u65ad\u7a00\u91ca\u6325\u53d1\u51fa\u6765\u7684\u84b8\u6c14\u548c\u51dd\u7ed3\u7269\u662f\u4fdd\u5b58HN3\u6eb6\u6db2\u7684\u6700\u597d\u529e\u6cd5\uff08\u6709\u8ba1\u7b97\u8bc1\u660e\u8fd9\u79cd\u65b9\u6cd5\u80fd\u4f7f\u6d53\u5ea6\u7ef4\u6301\u5728\u5b89\u5168\u6d53\u5ea6\u4ee5\u4e0b\uff09\uff0c\u5728\u6709HN3\u751f\u6210\u7684\u53cd\u5e94\u4e2d\uff0c\u4e3a\u4e86\u9632\u6b62\u51dd\u7ed3\u9700\u8981\u4e0d\u95f4\u65ad\u5730\u901a\u5165\u6c2e\u6c14\u5e76\u8ba9\u53cd\u5e94\u88c5\u7f6e\u7684\u6e29\u5ea6\u7ef4\u6301\u572837\u2103\u4ee5\u4e0a\u3002 2. \u907f\u514d\u66b4\u9732\u5728\u8fc7\u6e21\u91d1\u5c5e\u4e2d \u53e0\u6c2e\u5316\u94dc\uff08I\uff09\/\u94dc\uff08II\uff09\u4ee5\u53ca\u7c7b\u4f3c\u7269\u7684\u6df7\u5408\u7269\u5f15\u8d77\u7684\u7206\u70b8\u4e8b\u6545\u4e0d\u4e0b10\u4f59\u8d77\uff0c\u81f3\u5c11\u9020\u6210\u4e8616\u4eba\u7684\u6b7b\u4ea1\u3002\u7279\u522b\u662f\u7ed3\u6676\u6027\u56fa\u4f53\u7684\u53e0\u6c2e\u5316\u94dc(II)\uff0c\u5f88\u8f7b\u7684\u649e\u51fb\u4e5f\u80fd\u5728\u6c34\u4e2d\u5f15\u8d77\u6fc0\u70c8\u7684\u7206\u70b8\u3002\u5411\u542b\u6709\u65e0\u673a\u53e0\u6c2e\u5316\u7269\u6216\u8005HN3\u7684\u53cd\u5e94\u4e2d\u6dfb\u52a0\u8fc7\u6e21\u91d1\u5c5e\u662f\u4e00\u79cd\u5341\u5206\u5371\u9669\u7684\u884c\u4e3a\u3002\u5230\u73b0\u5728\u4e5f\u6ca1\u6709\u4ec0\u4e48\u53ef\u9760\u7684\u5411\u53e0\u6c2e\u5316\u7269\u4e2d\u52a0\u5165\u8fc7\u6e21\u91d1\u5c5e\u7684\u65b9\u6cd5\u3002Al, Ca, Ti, V, Cr, Mn, Co, Ni, Cu, Zn, Mo, Pd, Ag, Cd, Sn, Sb, Te, Ba, Pt, Au, Hg, Tl, Pb, Bi\u7b49\u91d1\u5c5e\u4f1a\u4e0e\u53e0\u6c2e\u5316\u7269\u751f\u6210\u53e0\u6c2e\u5316\u76d0\u3002\u5b9e\u9a8c\u5ba4\u79f0\u91cf\u53e0\u6c2e\u5316\u7269\u65f6\u4e0d\u80fd\u7528\u91d1\u5c5e\u836f\u5319\uff0c\u8981\u7528\u5851\u6599\u6216\u94c1\u6c1f\u9f99\u5236\u7684\u836f\u5319\u3002 \u8c03\u5236\u65e0\u673a\u53e0\u6c2e\u5316\u7269\u6216\u8005\u5de5\u4e1a\u5316\u751f\u4ea7\u53e0\u6c2e\u5316\u7269\u7684\u65f6\u5019\uff0c\u9700\u8981\u7279\u522b\u6ce8\u610f\u5c06\u91d1\u5c5e\u6392\u9664\u5728\u5916\u3002\u5305\u62ec\u53cd\u5e94\u7f38\u7684\u91d1\u5c5e\u96f6\u4ef6\uff0c\u91d1\u5c5e\u7684\u63a5\u5934\uff0c\u91d1\u5c5e\u7684\u70ed\u7535\u5bf9\uff0c\u91d1\u5c5e\u7684\u70ed\u7535\u5076\uff0c\u91d1\u5c5e\u94f2\u5b50\u6216\u91d1\u5c5e\u52fa\uff0c\u751a\u81f3\u5730\u9762\u6392\u6c34\u6c9f\u7684\u94dc\u5236\u7ba1\u9053\u90fd\u8981\u4e25\u683c\u4fdd\u62a4\u907f\u514d\u63a5\u89e6\u53e0\u6c2e\u5316\u7269\u3002 3. \u907f\u514d\u63a5\u89e6\u5364\u7d20\u6eb6\u5242 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\u5728\u5316\u5b66\u5de5\u573a\u66fe\u7ecf\u53d1\u751f\u8fc7\u4e00\u8d77\u4e25\u91cd\u7684\u5b89\u5168\u4e8b\u6545\u3002\u4e0b\u56fe2\u21923\u7684\u53e0\u6c2e\u57fa\u7684SN2\u53d6\u4ee3\u53cd\u5e94\u66fe\u7ecf\u5728\u540e\u5904\u7406\u65f6\u53d1\u751f\u8fc7\u7206\u70b8\u3002\u867d\u7136\u53cd\u5e94\u672c\u8eab\u7528\u7684\u662f\u5bf9\u53e0\u6c2e\u5316\u7269\u5b89\u5168\u7684DMF\uff0c\u4f46\u4e0a\u4e00\u6b65\u53cd\u5e94\u6b8b\u7559\u7684\u4e8c\u6c2f\u7532\u70f7\uff08DCM\uff09\u662f\u5f15\u8d77\u4e8b\u6545\u7684\u7f6a\u9b41\u7978\u9996\u30021\u21922\u7684\u53cd\u5e94\uff081kg\u89c4\u6a21\uff09\u7ed3\u675f\u540e\u867d\u7136\u84b8\u53d1\u4e86\u6eb6\u5242\u4f46\u662f\u6ca1\u6709\u5b8c\u5168\u9664\u5c3d\uff0c\u6b8b\u7559\u7684\u4e8c\u6c2f\u7532\u70f7\u5230\u4e86\u4e0b\u4e00\u6b65\u53cd\u5e94\u4e0eNaN3\u53cd\u5e94\u751f\u6210\u4e86\u91cd\u6c2e\u7532\u70f7\uff0c\u5728\u53cd\u5e94\u7ed3\u675f\u65f6\u6eb6\u5242\u88ab\u84b8\u53d1\u540e\u91cd\u6c2e\u7532\u70f7\u9ad8\u5ea6\u6d53\u7f29\u4ece\u800c\u5f15\u8d77\u5927\u7206\u70b8\u3002 \u5f15\u7528\uff1aOrg. Process Res. Dev.\u20022008,\u200212, 1285. \u9664\u4e86\u4f1a\u5728\u53cd\u5e94\u6eb6\u5242\u4e0a\u201c\u7ffb\u8f66\u201d\uff0c\u53cd\u5e94\u7ed3\u675f\u540e\u7684\u5904\u7406\u8fc7\u7a0b\u4e2d\u5206\u6db2\u6240\u7528\u7684\u8403\u53d6\u6eb6\u5242\u4e0d\u5c0f\u5fc3\u7528\u4e86\u4e8c\u6c2f\u7532\u70f7\u4e5f\u4f1a\u201c\u7ffb\u8f66\u201d\uff0c\u8fd9\u6837\u7684\u60e8\u6848\u5c61\u5c61\u53d1\u751f\u3002\u53e0\u6c2e\u53cd\u5e94\u5230\u5904\u90fd\u6f5c\u4f0f\u7740\u5371\u9669\uff0c\u6240\u4ee5\u8981\u683c\u5916\u6ce8\u610f\u548c\u5c0f\u5fc3\u3002 \u4eca\u5929\u7684\u4e3b\u8981\u76ee\u7684\u662f\u5524\u8d77\u5404\u4f4d\u5b9e\u9a8c\u5ba4\u201c\u642c\u7816\u4eba\u201d\u5bf9\u5371\u9669\u7684\u65e0\u673a\u53e0\u6c2e\u5316\u7269\u7684\u8b66\u89c9\uff0c\u4f46\u4e0d\u8981\u5fd8\u4e86\u6709\u673a\u53e0\u6c2e\u5316\u7269\u4e5f\u4e00\u6837\u7684\u5371\u9669\u3002 \u5728\u8bba\u6587\u7684\u6700\u540e\uff0c\u4f5c\u8005\u548c\u5ba1\u7a3f\u4eba\u603b\u7ed3\u9053\u201c\u4e00\u5b9a\u8981\u5341\u5206\u5bc6\u5207\u6ce8\u610f\u5b89\u5168\u95ee\u9898\u3002\u4e3a\u4e86\u4e0d\u8ba9\u60b2\u5267\u91cd\u6f14\uff0c\u4e00\u5b9a\u8981\u52aa\u529b\u63d0\u5347\u5e94\u5bf9\u5371\u9669\u72b6\u51b5\u7684\u77e5\u8bc6\u50a8\u5907\u201d\u3002\u65e0\u8bba\u662f\u591a\u5371\u9669\u7684\u8bd5\u5242\u53ea\u8981\u53d6\u7528\u5f97\u5f53\uff0c\u4e5f\u662f\u4e00\u628a\u5229\u5251\u3002\u5fc3\u4e2d\u77e5\u8bc6\u8db3\uff0c\u5b9e\u9a8c\u7a33\u5f53\u5f53\u3002 \u5728\u7bc7\u8bba\u6587\u520a\u767b\u524d\uff0cJOC\u6742\u5fd7\u5c31\u6709\u4e00\u7bc7\u51fa\u81eaGazvoda\u7684\u6587\u7ae0\u3002 \u5f15\u7528\u81ea\u8bba\u6587J. Org. 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