{"id":44733,"date":"2023-03-01T08:00:28","date_gmt":"2023-03-01T00:00:28","guid":{"rendered":"\/\/www.gsbet888.com\/?p=44733"},"modified":"2023-02-28T09:14:43","modified_gmt":"2023-02-28T01:14:43","slug":"jacs%ef%bc%9a%e5%85%89%e5%8c%96%e5%ad%a6%e5%88%86%e5%ad%90%e9%97%b43%cf%832%cf%83-%e7%8e%af%e5%8a%a0%e6%88%90%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2023\/03\/jacs%ef%bc%9a%e5%85%89%e5%8c%96%e5%ad%a6%e5%88%86%e5%ad%90%e9%97%b43%cf%832%cf%83-%e7%8e%af%e5%8a%a0%e6%88%90%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6%e7%a0%94%e7%a9%b6.html","title":{"rendered":"JACS\uff1a\u5149\u5316\u5b66\u5206\u5b50\u95f4[3\u03c3+2\u03c3]-\u73af\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\u7814\u7a76"},"content":{"rendered":"<p>\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n<h4>\u5bfc\u8bfb\uff1a<\/h4>\n<p>\u8fd1\u65e5\uff0c\u7f8e\u56fdPennsylvania\u5927\u5b66\u7684G.\u00a0A. Molander\u8bfe\u9898\u7ec4\u5728<em>J. Am. Chem. Soc<\/em><em>.<\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u9996\u4f8b\u5149\u8bf1\u5bfc\u7684BCB (bicyclo[1.1.0]butane)\u4e0eCPA (cyclopropylamine)\u4e4b\u95f4\u7684\u5206\u5b50\u95f4 [3<em>\u03c3<\/em>+2<em>\u03c3<\/em>]\u73af\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u4e09\u53d6\u4ee3BCHep (bicyclo[3.1.1]heptane)\u5206\u5b50\u7684\u6784\u5efa\u3002<\/p>\n<blockquote><p>Photochemical Intermolecular [3<em>\u03c3<\/em>\u00a0+ 2<em>\u03c3<\/em>]-Cycloaddition for the\u00a0Construction of Aminobicyclo[3.1.1]heptanes<\/p>\n<p>Y.Zheng, W.Huang, R. Dhungana, A.\u00a0Granados, S.\u00a0Keess,\u00a0M.\u00a0Makvandi, G.\u00a0A. Molander, <em>J. J. Am. Chem. Soc<\/em><em>.<\/em><strong>2022<\/strong>, <em><i>144<\/i><\/em>, 23685. doi: <a href=\"https:\/\/doi.org\/10.1021\/jacs.2c11501\"><u>10.1021\/jacs.2c11501<\/u><\/a>.<\/p><\/blockquote>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-44735 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/5cab884367440b4487cda507e622b19d.png\" alt=\"\" width=\"859\" height=\"388\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/5cab884367440b4487cda507e622b19d.png 859w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/5cab884367440b4487cda507e622b19d-300x136.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/5cab884367440b4487cda507e622b19d-680x307.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/5cab884367440b4487cda507e622b19d-768x347.png 768w\" sizes=\"(max-width: 859px) 100vw, 859px\" \/><\/p>\n<p>\u6b63\u6587\uff1a<\/p>\n<p>\u76ee\u524d\uff0c\u6784\u5efaBCP (bicyclo[1.1.1]pentane)\u5206\u5b50\u7684\u5408\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\u7814\u7a76\uff0c\u5df2\u7ecf\u5907\u53d7\u8bf8\u591a\u7814\u7a76\u56e2\u961f\u7684\u5e7f\u6cdb\u5173\u6ce8<sup>[1]<\/sup>\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u6784\u5efaBCHep (bicyclo[3.1.1]heptane)\u5206\u5b50\u7684\u5408\u6210\u8f6c\u5316\u7b56\u7565\uff0c\u76ee\u524d\u5374\u8f83\u5c11\u6709\u76f8\u5173\u7684\u7814\u7a76\u62a5\u9053 (Figure 1)<sup>\u00a0[2]<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-44736 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/7db594870e2eabb744c189f9dc70ba7d.png\" alt=\"\" width=\"876\" height=\"745\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/7db594870e2eabb744c189f9dc70ba7d.png 876w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/7db594870e2eabb744c189f9dc70ba7d-300x255.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/7db594870e2eabb744c189f9dc70ba7d-680x578.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/7db594870e2eabb744c189f9dc70ba7d-768x653.png 768w\" sizes=\"(max-width: 876px) 100vw, 876px\" \/><\/p>\n<p>\u8fd9\u91cc\uff0c\u53d7\u5230\u8fd1\u5e74\u6765\u5bf9\u4e8e\u91c7\u7528BCB\u5206\u5b50\u53c2\u4e0e\u5206\u5b50\u95f4[2+2]\u5149\u73af\u52a0\u6210<sup>[3]<\/sup>\u53cd\u5e94\u65b9\u6cd5\u5b66\u3001\u5206\u5b50\u5185[3<em>\u03c3<\/em>+2<em>\u03c0<\/em>]\u73af\u52a0\u6210<sup>[4]<\/sup>\u53cd\u5e94\u65b9\u6cd5\u5b66\u4ee5\u53ca\u5206\u5b50\u95f4[3<em>\u03c3<\/em>+2<em>\u03c0<\/em>]\u73af\u52a0\u6210\u53cd\u5e94<sup>[5]<\/sup>\u65b9\u6cd5\u5b66\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u7f8e\u56fdPennsylvania\u5927\u5b66\u7684G.\u00a0A. Molander\u8bfe\u9898\u7ec4\u62a5\u9053\u9996\u4f8b\u5149\u8bf1\u5bfc\u7684BCB (bicyclo[1.1.0]butane)\u4e0eCPA (cyclopropylamine)\u4e4b\u95f4\u7684\u5206\u5b50\u95f4 [3<em>\u03c3<\/em>+2<em>\u03c3<\/em>]\u73af\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66 (Figure 2)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-44737 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/673f423d0b05b153b04b065047e404d0.png\" alt=\"\" width=\"924\" height=\"1528\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/673f423d0b05b153b04b065047e404d0.png 924w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/673f423d0b05b153b04b065047e404d0-181x300.png 181w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/673f423d0b05b153b04b065047e404d0-619x1024.png 619w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/673f423d0b05b153b04b065047e404d0-768x1270.png 768w\" sizes=\"(max-width: 924px) 100vw, 924px\" \/><\/p>\n<p>\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528BCB <strong>1a<\/strong>\u4e0eCPA\u00a0<strong>2a<\/strong>\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528Ir[dF(CF<sub>3<\/sub>)ppy]<sub>2<\/sub>(dtbpy)PF<sub>6<\/sub>\u4f5c\u4e3a\u5149\u50ac\u5316\u5242\uff0c427 nm \u84dd\u5149 (Kessil\u00a0Lamp)\u8f90\u5c04\uff0c DMSO\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a\u5ba4\u6e29\uff0c\u6700\u7ec8\u83b7\u5f9770%\u6536\u7387\u7684BCHep\u4ea7\u7269<strong>3<\/strong>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-44738 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/860e799de1a3aecc36bc70eff0105b2c.png\" alt=\"\" width=\"898\" height=\"1253\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/860e799de1a3aecc36bc70eff0105b2c.png 898w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/860e799de1a3aecc36bc70eff0105b2c-215x300.png 215w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/860e799de1a3aecc36bc70eff0105b2c-680x949.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/860e799de1a3aecc36bc70eff0105b2c-768x1072.png 768w\" sizes=\"(max-width: 898px) 100vw, 898px\" \/><\/p>\n<p>\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5206\u522b\u5bf9\u4e00\u7cfb\u5217CPA\u4e0eBCB\u5e95\u7269 (Table 2)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-44739 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/b6a7d202bf3e15464eb8ef4090b7e76d.png\" alt=\"\" width=\"1080\" height=\"892\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/b6a7d202bf3e15464eb8ef4090b7e76d.png 1080w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/b6a7d202bf3e15464eb8ef4090b7e76d-300x248.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/b6a7d202bf3e15464eb8ef4090b7e76d-680x562.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/b6a7d202bf3e15464eb8ef4090b7e76d-768x634.png 768w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-44740 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/5f76d4fd9fd124369fd662251f4eebae.png\" alt=\"\" width=\"1107\" height=\"471\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/5f76d4fd9fd124369fd662251f4eebae.png 1107w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/5f76d4fd9fd124369fd662251f4eebae-300x128.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/5f76d4fd9fd124369fd662251f4eebae-680x289.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/5f76d4fd9fd124369fd662251f4eebae-768x327.png 768w\" sizes=\"(max-width: 1107px) 100vw, 1107px\" \/><\/p>\n<p>\u540c\u65f6\uff0c\u57fa\u4e8e\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053<sup>[4]-[6]<\/sup>\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 1)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-44741 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/a229482721b26fee855b15ffea58804f.png\" alt=\"\" width=\"891\" height=\"730\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/a229482721b26fee855b15ffea58804f.png 891w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/a229482721b26fee855b15ffea58804f-300x246.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/a229482721b26fee855b15ffea58804f-680x557.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/a229482721b26fee855b15ffea58804f-768x629.png 768w\" sizes=\"(max-width: 891px) 100vw, 891px\" \/><\/p>\n<p>\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u5206\u5b50\u95f4[3<em>\u03c3<\/em>+2<em>\u03c3<\/em>]-\u73af\u52a0\u6210\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u00a0(Scheme 2)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-44742 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/24a3f5de9426d1a981992d25f7e46483.png\" alt=\"\" width=\"882\" height=\"742\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/24a3f5de9426d1a981992d25f7e46483.png 882w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/24a3f5de9426d1a981992d25f7e46483-300x252.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/24a3f5de9426d1a981992d25f7e46483-680x572.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/02\/24a3f5de9426d1a981992d25f7e46483-768x646.png 768w\" sizes=\"(max-width: 882px) 100vw, 882px\" \/><\/p>\n<p>\u603b\u7ed3\uff1a\u7f8e\u56fdPennsylvania\u5927\u5b66\u7684G.\u00a0A. Molander\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u9996\u4f8b\u5149\u8bf1\u5bfc\u7684BCB (bicyclo[1.1.0]butane)\u4e0eCPA (cyclopropylamine)\u4e4b\u95f4\u7684\u5206\u5b50\u95f4 [3<em>\u03c3<\/em>+2<em>\u03c3<\/em>]\u73af\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u4e09\u53d6\u4ee3BCHep\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684[3<em>\u03c3<\/em>+2<em>\u03c3<\/em>]\u73af\u52a0\u6210\u7b56\u7565\u5177\u6709\u6e29\u548c\u7684\u53cd\u5e94\u6761\u4ef6\u3001\u5e7f\u6cdb\u7684\u5e95\u7269\u8303\u56f4\u4ee5\u53ca\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u7b49\u4f18\u52bf\u3002<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ul>\n<li>[1] J.\u00a0Kanazawa,\u00a0M.\u00a0Uchiyama, <em><i>Synlett <\/i><\/em><strong>2019<\/strong>, <em><i>30<\/i><\/em>, 1.\u00a0doi: <a href=\"https:\/\/www.thieme-connect.de\/products\/ejournals\/abstract\/10.1055\/s-0037-1610314\"><u>10.1055\/s-0037-1610314<\/u><\/a>.<\/li>\n<li>[2] T.\u00a0Iida, J. Kanazawa, T. Matsunaga, K.\u00a0Miyamoto, K. Hirano, M. Uchiyama, <em><i>J. Am. Chem. Soc. <\/i><\/em><strong>2022<\/strong>, 21848.\u00a0doi: <a href=\"https:\/\/doi.org\/10.1021\/jacs.2c09733\"><u>10.1021\/jacs.2c09733<\/u><\/a>.<\/li>\n<li>[3]\u00a0Y.\u00a0Liang, R.\u00a0Kleinmans, C. G. Daniliuc,\u00a0F.\u00a0Glorius, <em><i>J. Am. Chem. Soc. <\/i><\/em><strong>2022<\/strong>,<\/li>\n<li><em><i>144<\/i><\/em>, 20207.\u00a0doi: <a href=\"https:\/\/doi.org\/10.1021\/jacs.2c09248\"><u>10.1021\/jacs.2c09248<\/u><\/a>.<\/li>\n<li>[4] D.\u00a0Staveness, J.\u00a0L. Collins, R. C. McAtee, C. R. J. Stephenson, \u00a0<em><i>Angew. Chem., Int. Ed. <\/i><\/em><strong>2019<\/strong>, <em><i>58<\/i><\/em>, 19000.\u00a0doi: <a href=\"https:\/\/doi.org\/10.1002\/anie.201909492\"><u>10.1002\/anie.201909492<\/u><\/a>.<\/li>\n<li>[5] B.\u00a0Muriel, A. Gagnebin, J. Waser, <em><i>Chem. Sci. <\/i><\/em><strong>2019<\/strong>, <em><i>10<\/i><\/em>, 10716.\u00a0doi: <a href=\"https:\/\/doi.org\/10.1039\/C9SC03790J\"><u>10.1039\/C9SC03790J<\/u><\/a>.<\/li>\n<li>[6] Y.\u00a0Cai, J. Wang, Y. Zhang, Z. Li, D. Hu, N. Zheng,\u00a0H. Chen, <em><i>J. Am. Chem. Soc. <\/i><\/em><strong>2017<\/strong>, <em><i>139<\/i><\/em>,\u00a012259.\u00a0doi:<a href=\"https:\/\/doi.org\/10.1021\/jacs.7b06319\"><u>10.1021\/jacs.7b06319<\/u><\/a>.<\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb\uff1a \u8fd1\u65e5\uff0c\u7f8e\u56fdPennsylvania\u5927\u5b66\u7684G.\u00a0A. Molander\u8bfe\u9898\u7ec4\u5728J. Am. Chem. Soc.\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u9996\u4f8b\u5149\u8bf1\u5bfc\u7684BCB (bicyclo[1.1.0]butane)\u4e0eCPA (cyclopropylamine)\u4e4b\u95f4\u7684\u5206\u5b50\u95f4 [3\u03c3+2\u03c3]\u73af\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u4e09\u53d6\u4ee3BCHep (bicyclo[3.1.1]heptane)\u5206\u5b50\u7684\u6784\u5efa\u3002 Photochemical Intermolecular [3\u03c3\u00a0+ 2\u03c3]-Cycloaddition for the\u00a0Construction of Aminobicyclo[3.1.1]heptanes Y.Zheng, W.Huang, R. Dhungana, A.\u00a0Granados, S.\u00a0Keess,\u00a0M.\u00a0Makvandi, G.\u00a0A. Molander, J. J. Am. Chem. Soc.2022, 144, 23685. doi: 10.1021\/jacs.2c11501. \u6b63\u6587\uff1a \u76ee\u524d\uff0c\u6784\u5efaBCP (bicyclo[1.1.1]pentane)\u5206\u5b50\u7684\u5408\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\u7814\u7a76\uff0c\u5df2\u7ecf\u5907\u53d7\u8bf8\u591a\u7814\u7a76\u56e2\u961f\u7684\u5e7f\u6cdb\u5173\u6ce8[1]\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u6784\u5efaBCHep (bicyclo[3.1.1]heptane)\u5206\u5b50\u7684\u5408\u6210\u8f6c\u5316\u7b56\u7565\uff0c\u76ee\u524d\u5374\u8f83\u5c11\u6709\u76f8\u5173\u7684\u7814\u7a76\u62a5\u9053 (Figure 1)\u00a0[2]\u3002 \u8fd9\u91cc\uff0c\u53d7\u5230\u8fd1\u5e74\u6765\u5bf9\u4e8e\u91c7\u7528BCB\u5206\u5b50\u53c2\u4e0e\u5206\u5b50\u95f4[2+2]\u5149\u73af\u52a0\u6210[3]\u53cd\u5e94\u65b9\u6cd5\u5b66\u3001\u5206\u5b50\u5185[3\u03c3+2\u03c0]\u73af\u52a0\u6210[4]\u53cd\u5e94\u65b9\u6cd5\u5b66\u4ee5\u53ca\u5206\u5b50\u95f4[3\u03c3+2\u03c0]\u73af\u52a0\u6210\u53cd\u5e94[5]\u65b9\u6cd5\u5b66\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u7f8e\u56fdPennsylvania\u5927\u5b66\u7684G.\u00a0A. Molander\u8bfe\u9898\u7ec4\u62a5\u9053\u9996\u4f8b\u5149\u8bf1\u5bfc\u7684BCB (bicyclo[1.1.0]butane)\u4e0eCPA (cyclopropylamine)\u4e4b\u95f4\u7684\u5206\u5b50\u95f4 [3\u03c3+2\u03c3]\u73af\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66 (Figure 2)\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528BCB 1a\u4e0eCPA\u00a02a\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528Ir[dF(CF3)ppy]2(dtbpy)PF6\u4f5c\u4e3a\u5149\u50ac\u5316\u5242\uff0c427 nm \u84dd\u5149 (Kessil\u00a0Lamp)\u8f90\u5c04\uff0c DMSO\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a\u5ba4\u6e29\uff0c\u6700\u7ec8\u83b7\u5f9770%\u6536\u7387\u7684BCHep\u4ea7\u72693\u3002 \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5206\u522b\u5bf9\u4e00\u7cfb\u5217CPA\u4e0eBCB\u5e95\u7269 (Table 2)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002 \u540c\u65f6\uff0c\u57fa\u4e8e\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053[4]-[6]\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 1)\u3002 \u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u5206\u5b50\u95f4[3\u03c3+2\u03c3]-\u73af\u52a0\u6210\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u00a0(Scheme 2)\u3002 \u603b\u7ed3\uff1a\u7f8e\u56fdPennsylvania\u5927\u5b66\u7684G.\u00a0A. Molander\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u9996\u4f8b\u5149\u8bf1\u5bfc\u7684BCB (bicyclo[1.1.0]butane)\u4e0eCPA (cyclopropylamine)\u4e4b\u95f4\u7684\u5206\u5b50\u95f4 [3\u03c3+2\u03c3]\u73af\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u4e09\u53d6\u4ee3BCHep\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684[3\u03c3+2\u03c3]\u73af\u52a0\u6210\u7b56\u7565\u5177\u6709\u6e29\u548c\u7684\u53cd\u5e94\u6761\u4ef6\u3001\u5e7f\u6cdb\u7684\u5e95\u7269\u8303\u56f4\u4ee5\u53ca\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u7b49\u4f18\u52bf\u3002 \u00a0 \u53c2\u8003\u6587\u732e\uff1a [1] J.\u00a0Kanazawa,\u00a0M.\u00a0Uchiyama, Synlett 2019, 30, 1.\u00a0doi: 10.1055\/s-0037-1610314. [2] T.\u00a0Iida, J. Kanazawa, T. Matsunaga, K.\u00a0Miyamoto, K. Hirano, M. Uchiyama, J. Am. Chem. Soc. 2022, 21848.\u00a0doi: 10.1021\/jacs.2c09733. [3]\u00a0Y.\u00a0Liang, R.\u00a0Kleinmans, C. G. Daniliuc,\u00a0F.\u00a0Glorius, J. Am. Chem. Soc. 2022, 144, 20207.\u00a0doi: 10.1021\/jacs.2c09248. 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