{"id":44974,"date":"2023-03-17T08:00:18","date_gmt":"2023-03-17T00:00:18","guid":{"rendered":"\/\/www.gsbet888.com\/?p=44974"},"modified":"2023-03-16T21:59:25","modified_gmt":"2023-03-16T13:59:25","slug":"%e5%88%98%e6%96%87%e7%bb%84jacs%ef%bc%9a%e8%b5%9b%e6%99%ae%e9%9c%89%e7%b4%a0%e9%aa%a8%e6%9e%b6%e5%bd%a2%e6%88%90%e6%9c%ba%e5%88%b6%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2023\/03\/%e5%88%98%e6%96%87%e7%bb%84jacs%ef%bc%9a%e8%b5%9b%e6%99%ae%e9%9c%89%e7%b4%a0%e9%aa%a8%e6%9e%b6%e5%bd%a2%e6%88%90%e6%9c%ba%e5%88%b6%e7%a0%94%e7%a9%b6.html","title":{"rendered":"\u5218\u6587\u7ec4JACS\uff1a\u8d5b\u666e\u9709\u7d20\u9aa8\u67b6\u5f62\u6210\u673a\u5236\u7814\u7a76"},"content":{"rendered":"<p><strong><b>\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a<\/b><\/strong><\/p>\n<h4><strong><b>\u5bfc\u8bfb<\/b><\/strong><\/h4>\n<p>\u8fd1\u65e5\uff0c<strong><b>\u4e0a\u6d77\u6709\u673a\u5316\u5b66\u7814\u7a76\u6240\u5218\u6587\u7814\u7a76\u5458<\/b><\/strong>\u8bfe\u9898\u7ec4\u5bf9\u8d5b\u666e\u9709\u7d20\u7684\u9aa8\u67b6\u5f62\u6210\u673a\u5236\u5c55\u5f00\u4e86\u7814\u7a76\u3002\u7814\u7a76\u7ed3\u679c\u4fee\u6b63\u4e86\u8d5b\u666e\u9709\u7d20\u7684\u5316\u5b66\u7ed3\u6784\uff1a\u9664\u4e86\u5df2\u77e5\u7684\u8131\u6c22\u4e01\u80fa\u9178\u6b8b\u57fa\u5916\uff0c\u8be5\u5206\u5b50\u8fd8\u542b\u672a\u88ab\u53d1\u73b0\u768411\u4e2aD\u578b\u6c28\u57fa\u9178\u6b8b\u57fa\uff0c\u8868\u660e\u8d5b\u666e\u9709\u7d20\u662f\u4e00\u79cd\u957f\u671f\u4ee5\u6765\u88ab\u4f4e\u4f30\u4e86\u7684\u9ad8\u5ea6\u4fee\u9970\u6838\u7cd6\u4f53\u80bd\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u4ec5\u7531\u4e24\u4e2a\u819c\u86cb\u767d\u7684\u5171\u540c\u4f5c\u7528\uff0c\u4fbf\u80fd\u50ac\u5316\u80bd\u94fe\u4e0a\u76844\u4e2a\u82cf\u6c28\u9178\u8131\u6c34\u30011\u4e2a\u534a\u80f1\u6c28\u9178\u8131\u786b\u548c11\u4e2a\u6c28\u57fa\u9178\uff083\u4e2a\u4e19\u6c28\u9178\u30012\u4e2a\u7f2c\u6c28\u9178\u30012\u4e2a\u5929\u51ac\u9170\u80fa\u30012\u4e2a\u5f02\u4eae\u6c28\u9178\u30012\u4e2a\u812f\u6c28\u9178\uff09\u53d1\u751f\u5dee\u5411\u5f02\u6784\u5316\u53cd\u5e94\u3002<\/p>\n<blockquote><p>\u201cReconstitution of the Linaridin Pathway Provides Access to the Family-Determining Activity of Two Membrane-Associated Proteins in the Formation of Structurally Underestimated Cypemycin<\/p>\n<p>Yanqing Xue, Xiaofeng Wang, and Wen Liu*<\/p>\n<p><em>J<\/em><em>.<\/em><em> Chem. Soc<\/em>. <strong><b>2023<\/b><\/strong>, <em><i>ASAP<\/i><\/em>DOI:\u00a0<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.3c01730\"><u>10.1021\/jacs.3c01730<\/u><u>\u00a0<\/u><\/a>\u201d<\/p><\/blockquote>\n<p>&nbsp;<\/p>\n<h4><strong><b>\u6b63\u6587<\/b><\/strong><strong><b>: <\/b><\/strong><\/h4>\n<p>\u6838\u7cd6\u4f53\u80bd\u662f\u81ea\u7136\u754c\u901a\u8fc7\u7ffb\u8bd1\u540e\u4fee\u9970\u5316\u5b66\u521b\u9020\u7684\u4e00\u7c7b\u7ed3\u6784\u590d\u6742\u3001\u6d3b\u6027\u4f18\u826f\u7684\u80bd\u7c7b\u5929\u7136\u4ea7\u7269\u3002\u8bb8\u591a\u6709\u5e7f\u6cdb\u5e94\u7528\u7684\u6297\u751f\u7d20\uff0c\u5982\u4e73\u9178\u94fe\u7403\u83cc\u7d20\u548c\u786b\u94fe\u4e1d\u83cc\u7d20\uff0c\u5747\u901a\u8fc7\u7ffb\u8bd1\u540e\u4fee\u9970\u5316\u5b66\u4ece20\u79cd\u5929\u7136\u6c28\u57fa\u9178\u6784\u6210\u7684\u7b80\u5355\u591a\u80bd\u8f6c\u5316\u800c\u6765\u3002\u4e0a\u6d77\u6709\u673a\u6240\u5218\u6587\u8bfe\u9898\u7ec4\u957f\u671f\u4ece\u4e8b\u5bcc\u786b\u7ec6\u83cc\u73af\u80bd\u7684\u7ffb\u8bd1\u540e\u4fee\u9970\u5316\u5b66\u7814\u7a76\uff0c\u8fd1\u671f\u5bf9\u76f8\u5173\u80bd\u7684\u4e3b\u94fe\u9aa8\u67b6\u4fee\u9970\u3001\u6c2e\u6742\u6838\u5fc3\u73af\u7684\u5f62\u6210\u4ee5\u53ca\u975e\u5929\u7136\u6c28\u57fa\u9178\u7684\u5f15\u5165\u7b49\u9176\u4fc3\u53cd\u5e94\u8fc7\u7a0b\u8fdb\u884c\u4e86\u5256\u6790\uff08<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.0c02329\"><em><u><i>J. Am. Chem. Soc. <\/i><\/u><\/em><strong><u><b>2020<\/b><\/u><\/strong><em><u><i>, 142, <\/i><\/u><\/em><u>8454\u20138463<\/u><\/a>;<em><i>\u00a0<\/i><\/em><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.1c05956\"><em><u><i>J. Am. Chem. Soc.<\/i><\/u><\/em><u>\u00a0<\/u><strong><u><b>2021<\/b><\/u><\/strong><u>, <\/u><em><u><i>143<\/i><\/u><\/em><u>, 13790\u221213797<\/u><\/a>;<em><i>\u00a0<\/i><\/em><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2451945620305250?via%3Dihub\"><em><u><i>Cell Chem. Biol.<\/i><\/u><\/em><u>\u00a0<\/u><strong><u><b>2021<\/b><\/u><\/strong><u>, <\/u><em><u><i>28<\/i><\/u><\/em><u>, 675-685<\/u><\/a>;\u00a0<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.1c11669\"><em><u><i>J. Am. Chem. Soc. <\/i><\/u><\/em><strong><u><b>2022<\/b><\/u><\/strong><em><u><i>, 144<\/i><\/u><\/em><em><u><i>,<\/i><\/u><\/em><em><u><i>\u00a0<\/i><\/u><\/em><u>4431-4438<\/u><\/a>\uff09\u3002<\/p>\n<p>\u8d5b\u666e\u9709\u7d20\u662f\u94fe\u9709\u83cc\u4ea7\u751f\u7684\u4e00\u7c7b\u6838\u7cd6\u4f53\u80bd\uff0c\u5177\u6709\u663e\u8457\u6291\u5236\u85e4\u9ec4\u5fae\u7403\u83cc\u548c\u5c0f\u9f20\u767d\u8840\u75c5\u7ec6\u80de\u751f\u957f\u7684\u4f5c\u7528\u3002\u81ea\u53d1\u73b0\u4ee5\u6765\u4e09\u5341\u4f59\u5e74\uff0c\u4eba\u4eec\u5bf9\u8be5\u7c7b\u6838\u7cd6\u4f53\u80bd\u7684\u7ffb\u8bd1\u540e\u4fee\u9970\u8fc7\u7a0b\u77e5\u4e4b\u751a\u5c11\u3002\u57fa\u4e8e\u524d\u671f\u5de5\u4f5c\u57fa\u7840\uff0c\u5218\u6587\u8bfe\u9898\u7ec4\u5bf9\u8be5\u5206\u5b50\u7684\u9aa8\u67b6\u5f62\u6210\u673a\u5236\u5c55\u5f00\u4e86\u7814\u7a76\u3002\u7814\u7a76\u7ed3\u679c\u4fee\u6b63\u4e86\u8d5b\u666e\u9709\u7d20\u7684\u5316\u5b66\u7ed3\u6784\uff1a\u9664\u4e86\u5df2\u77e5\u7684\u8131\u6c22\u4e01\u80fa\u9178\u6b8b\u57fa\u5916\uff0c\u8be5\u5206\u5b50\u8fd8\u542b\u672a\u88ab\u53d1\u73b0\u768411\u4e2aD\u578b\u6c28\u57fa\u9178\u6b8b\u57fa\uff0c\u8868\u660e\u8d5b\u666e\u9709\u7d20\u662f\u4e00\u79cd\u957f\u671f\u4ee5\u6765\u88ab\u4f4e\u4f30\u4e86\u7684\u9ad8\u5ea6\u4fee\u9970\u6838\u7cd6\u4f53\u80bd\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u4ec5\u7531\u4e24\u4e2a\u819c\u86cb\u767d\u7684\u5171\u540c\u4f5c\u7528\uff0c\u4fbf\u80fd\u50ac\u5316\u80bd\u94fe\u4e0a\u76844\u4e2a\u82cf\u6c28\u9178\u8131\u6c34\u30011\u4e2a\u534a\u80f1\u6c28\u9178\u8131\u786b\u548c11\u4e2a\u6c28\u57fa\u9178\uff083\u4e2a\u4e19\u6c28\u9178\u30012\u4e2a\u7f2c\u6c28\u9178\u30012\u4e2a\u5929\u51ac\u9170\u80fa\u30012\u4e2a\u5f02\u4eae\u6c28\u9178\u30012\u4e2a\u812f\u6c28\u9178\uff09\u53d1\u751f\u5dee\u5411\u5f02\u6784\u5316\u53cd\u5e94\u3002<\/p>\n<p><img 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of the American Chemical Society<\/i><\/em>\u201d\u4e0a\u53d1\u8868\uff08DOI\uff1a10.1021\/jacs.3c01730\uff09\u3002\u8be5\u5de5\u4f5c\u5f97\u5230\u79d1\u6280\u90e8\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u59d4\u76f8\u5173\u57fa\u91d1\u7684\u5927\u529b\u8d44\u52a9\u3002<\/p>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a \u5bfc\u8bfb 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\u201cReconstitution of the Linaridin Pathway Provides Access to the Family-Determining Activity of Two Membrane-Associated Proteins in the Formation of Structurally Underestimated Cypemycin Yanqing Xue, Xiaofeng Wang, and Wen Liu* J. Chem. 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