{"id":45285,"date":"2023-04-06T08:00:48","date_gmt":"2023-04-06T00:00:48","guid":{"rendered":"\/\/www.gsbet888.com\/?p=45285"},"modified":"2023-04-02T18:44:28","modified_gmt":"2023-04-02T10:44:28","slug":"org-lett-%ef%bc%9a%e8%87%aa%e7%94%b1%e5%9f%bagem-iodoallylation%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2023\/04\/org-lett-%ef%bc%9a%e8%87%aa%e7%94%b1%e5%9f%bagem-iodoallylation%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6%e7%a0%94%e7%a9%b6.html","title":{"rendered":"Org. Lett.\uff1a\u81ea\u7531\u57fagem-Iodoallylation\u53cd\u5e94\u65b9\u6cd5\u5b66\u7814\u7a76"},"content":{"rendered":"<p style=\"text-align: justify;\">\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n<h4 style=\"text-align: justify;\">\u5bfc\u8bfb\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u8fd1\u65e5\uff0c\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u7684\u5434\u56fd\u9a84\u8bfe\u9898\u7ec4\u5728<em><i>Org. Lett.<\/i><\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u53ef\u89c1\u5149\u8bf1\u5bfc\u7684CF<sub>3<\/sub>CHN<sub>2<\/sub>\u3001\u7898\u4e0e\u70ef\u4e19\u57fa\u781c\u884d\u751f\u7269\u4e4b\u95f4\u7684\u81ea\u7531\u57fa<em><i>gem<\/i><\/em>-Iodoallylation\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709<em>\u03b1<\/em>-CF<sub>3<\/sub>-\u53d6\u4ee3\u7684\u9ad8\u70ef\u4e19\u57fa\u7898\u5206\u5b50\u7684\u6784\u5efa\u3002<\/p>\n<blockquote><p>Visible-Light-Induced Radical <em>gem<\/em>-Iodoallylation of 2,2,2-Trifluorodiazoethane<\/p>\n<p>Liu, T. Pang, W. Yao, F. Zhong, G. Wu, <em><i>Org. Lett.<\/i><\/em><strong>2023<\/strong>, <em><i>25,<\/i><\/em>1958. doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.3c00464\"><u>10.1021\/acs.orglett.3c00464<\/u><\/a><u>.<\/u><\/p><\/blockquote>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-45287 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/158498a5ec10bd08fbceb4e1128e5121.png\" alt=\"\" width=\"928\" height=\"312\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/158498a5ec10bd08fbceb4e1128e5121.png 928w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/158498a5ec10bd08fbceb4e1128e5121-300x101.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/158498a5ec10bd08fbceb4e1128e5121-680x229.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/158498a5ec10bd08fbceb4e1128e5121-768x258.png 768w\" sizes=\"(max-width: 928px) 100vw, 928px\" \/><\/p>\n<h4 style=\"text-align: justify;\">\u6b63\u6587\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u4e09\u6c1f\u7532\u57fa\u7ed3\u6784\u5355\u5143\u5e7f\u6cdb\u5b58\u5728\u4e8e\u4e00\u7cfb\u5217\u519c\u7528\u5316\u5b66\u54c1\u3001\u836f\u54c1\u4ee5\u53ca\u5404\u7c7b\u529f\u80fd\u6750\u6599\u4e2d\u3002\u5e76\u4e14\uff0c\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u91c7\u7528CF<sub>3<\/sub>CHN<sub>2<\/sub>\u53c2\u4e0e\u7684\u6709\u673a\u5408\u6210\u8f6c\u5316\u7b56\u7565\u7684\u76f8\u5173\u7814\u7a76\uff0c\u4ee5\u53ca\u5907\u53d7\u8bf8\u591a\u7814\u7a76\u56e2\u961f\u7684\u5e7f\u6cdb\u5173\u6ce8\u00a0(Figure 1)<sup>\u00a0[1]-[<\/sup><sup>4<\/sup><sup>]<\/sup>\u3002\u8fd9\u91cc\uff0c\u53d7\u5230\u8fd1\u5e74\u6765\u901a\u8fc7C-I\u952e\u65ad\u88c2\u5f62\u6210\u7684\u81ea\u7531\u57fa\u53c2\u4e0e\u7684\u5149\u5316\u5b66\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[5]<\/sup>\u4ee5\u53ca\u5728\u5149\u6c27\u5316\u8fd8\u539f\u6216\u70ed\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u901a\u8fc7\u4e8c\u7898\u4e59\u9178\u4e59\u916f\u4e2d\u95f4\u4f53\u53c2\u4e0e\u7684\u73af\u52a0\u6210\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u5b58\u5728\u7684\u91cd\u6c2e\u7fa7\u9178\u916f\u6d3b\u5316\u8def\u5f84<sup>[6]<\/sup>\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u7684\u5434\u56fd\u9a84\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u53ef\u89c1\u5149\u8bf1\u5bfc\u7684CF<sub>3<\/sub>CHN<sub>2<\/sub>\u3001\u7898\u4e0e\u70ef\u4e19\u57fa\u781c\u884d\u751f\u7269\u4e4b\u95f4\u7684\u81ea\u7531\u57fa<em><i>gem<\/i><\/em>-Iodoallylation\u53cd\u5e94\u65b9\u6cd5\u5b66 (Figure 1c)<span style=\"color: #000000;\">\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-45288 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/4e11479f2491373e9a9c5785df933d4b.png\" alt=\"\" width=\"919\" height=\"757\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/4e11479f2491373e9a9c5785df933d4b.png 919w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/4e11479f2491373e9a9c5785df933d4b-300x247.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/4e11479f2491373e9a9c5785df933d4b-680x560.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/4e11479f2491373e9a9c5785df933d4b-768x633.png 768w\" sizes=\"(max-width: 919px) 100vw, 919px\" \/><\/p>\n<p style=\"text-align: justify;\">\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528CF<sub>3<\/sub>CHN<sub>2<\/sub>\u4f5c\u4e3a\u6c1f\u70f7\u57fa\u5316\u8bd5\u5242 (fluoroalkylating reagent)\u3001I<sub>2<\/sub>\u4f5c\u4e3a\u7898\u5316\u8bd5\u5242\uff0c<strong>1a<\/strong>\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528[Ir(dtbbpy)(ppy)<sub>2<\/sub>]PF<sub>6<\/sub>\u4f5c\u4e3a\u5149\u50ac\u5316\u5242\uff0cEt<sub>3<\/sub>N\u4f5c\u4e3a\u78b1\uff0c\u84dd\u5149LED\u8f90\u5c04\uff0cDCM\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a\u5ba4\u6e29\uff0c\u6700\u7ec8\u83b7\u5f9787%\u6536\u7387\u7684<em><i>gem<\/i><\/em>-Iodoallylation\u4ea7\u7269<strong>2<\/strong>\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-45289 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/9658f91a78b0df67b1721c1daedb307f.png\" alt=\"\" width=\"909\" height=\"809\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/9658f91a78b0df67b1721c1daedb307f.png 909w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/9658f91a78b0df67b1721c1daedb307f-300x267.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/9658f91a78b0df67b1721c1daedb307f-680x605.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/9658f91a78b0df67b1721c1daedb307f-768x684.png 768w\" sizes=\"(max-width: 909px) 100vw, 909px\" \/><\/p>\n<p style=\"text-align: justify;\">\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217\u70ef\u4e19\u57fa\u781c\u5e95\u7269 (Scheme 1)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-45290 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/29c33da7e1a90dc277fcf9ee305ecdae.png\" alt=\"\" width=\"916\" height=\"1413\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/29c33da7e1a90dc277fcf9ee305ecdae.png 916w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/29c33da7e1a90dc277fcf9ee305ecdae-194x300.png 194w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/29c33da7e1a90dc277fcf9ee305ecdae-664x1024.png 664w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/29c33da7e1a90dc277fcf9ee305ecdae-768x1185.png 768w\" sizes=\"(max-width: 916px) 100vw, 916px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-45291 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/79da57ac4d29f80e649c7f9f13b33cc3.png\" alt=\"\" width=\"1109\" height=\"429\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/79da57ac4d29f80e649c7f9f13b33cc3.png 1109w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/79da57ac4d29f80e649c7f9f13b33cc3-300x116.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/79da57ac4d29f80e649c7f9f13b33cc3-680x263.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/79da57ac4d29f80e649c7f9f13b33cc3-768x297.png 768w\" sizes=\"(max-width: 1109px) 100vw, 1109px\" \/><\/p>\n<p style=\"text-align: justify;\">\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u81ea\u7531\u57fa<em><i>gem<\/i><\/em>-Iodoallylation\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u00a0(Scheme 2)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-45292 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/865de3dd4bf26f02e4bfee09886a99a1.png\" alt=\"\" width=\"915\" height=\"859\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/865de3dd4bf26f02e4bfee09886a99a1.png 915w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/865de3dd4bf26f02e4bfee09886a99a1-300x282.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/865de3dd4bf26f02e4bfee09886a99a1-680x638.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/865de3dd4bf26f02e4bfee09886a99a1-768x721.png 768w\" sizes=\"(max-width: 915px) 100vw, 915px\" \/><\/p>\n<p style=\"text-align: justify;\">\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u5bf9\u4e0a\u8ff0\u81ea\u7531\u57fa<em>gem<\/em>-Iodoallylation\u8fc7\u7a0b\u7684\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u7814\u7a76\u00a0(Figure 2)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-45293 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/ddd7d4429bfd076e1aaf048bbb67f595.png\" alt=\"\" width=\"912\" height=\"761\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/ddd7d4429bfd076e1aaf048bbb67f595.png 912w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/ddd7d4429bfd076e1aaf048bbb67f595-300x250.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/ddd7d4429bfd076e1aaf048bbb67f595-680x567.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/ddd7d4429bfd076e1aaf048bbb67f595-768x641.png 768w\" sizes=\"(max-width: 912px) 100vw, 912px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-45294 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/654da566da71b681c755e64fb54ae49b.png\" alt=\"\" width=\"1106\" height=\"578\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/654da566da71b681c755e64fb54ae49b.png 1106w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/654da566da71b681c755e64fb54ae49b-300x157.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/654da566da71b681c755e64fb54ae49b-680x355.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/654da566da71b681c755e64fb54ae49b-768x401.png 768w\" sizes=\"(max-width: 1106px) 100vw, 1106px\" \/><\/p>\n<p style=\"text-align: justify;\">\u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\u4ee5\u53ca\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053<sup>[7]-[8]<\/sup>\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Figure 3)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-45295 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/46471f2e18040743f1d301511a1fa627.png\" alt=\"\" width=\"921\" height=\"524\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/46471f2e18040743f1d301511a1fa627.png 921w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/46471f2e18040743f1d301511a1fa627-300x171.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/46471f2e18040743f1d301511a1fa627-680x387.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/46471f2e18040743f1d301511a1fa627-768x437.png 768w\" sizes=\"(max-width: 921px) 100vw, 921px\" \/><\/p>\n<p style=\"text-align: justify;\">\u603b\u7ed3\uff1a\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u7684\u5434\u56fd\u9a84\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u53ef\u89c1\u5149\u8bf1\u5bfc\u7684CF<sub>3<\/sub>CHN<sub>2<\/sub>\u3001\u7898\u4e0e\u70ef\u4e19\u57fa\u781c\u884d\u751f\u7269\u4e4b\u95f4\u7684\u81ea\u7531\u57fa<em><i>gem<\/i><\/em>-Iodoallylation\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709<em>\u03b1<\/em>-CF<sub>3<\/sub>-\u53d6\u4ee3\u7684\u9ad8\u70ef\u4e19\u57fa\u7898\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u81ea\u7531\u57fa<em><i>gem<\/i><\/em>-Iodoallylation\u7b56\u7565\u5177\u6709\u5e7f\u6cdb\u7684\u5e95\u7269\u5e94\u7528\u8303\u56f4\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u6e29\u548c\u7684\u53cd\u5e94\u6761\u4ef6\u7b49\u4f18\u52bf\u3002<\/p>\n<h4 style=\"text-align: justify;\"><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ul style=\"text-align: justify;\">\n<li>[1] L.\u00a0Mertens, R. M. Koenigs, <em><i>Org. Biomol. Chem. <\/i><\/em><strong>2016<\/strong>, <em><i>14<\/i><\/em>, 10547. doi:<a href=\"https:\/\/doi.org\/10.1039\/C6OB01618A\"><u>10.1039\/C6OB01618A<\/u><\/a><u>.<\/u><\/li>\n<li>[2]\u00a0X.\u00a0Zhang, Z. Liu, X. Yang, Y. Dong, M. Virelli, G. Zanoni, E. A. Anderson, X.\u00a0Bi,\u00a0<em><i>Nat. Commun. <\/i><\/em><strong>2019<\/strong>, <em><i>10<\/i><\/em>, 284.\u00a0doi:<a href=\"https:\/\/doi.org\/10.1038\/s41467-018-08253-z\"><u>10.1038\/s41467-018-08253-z<\/u><\/a><u>.<\/u><\/li>\n<li>[3]\u00a0S. J. T.\u00a0Jonker, R. Jayarajan, T. Kireilis, M. Deliaval, L. Eriksson, K. J. Szabo, <em><i>J. Am. Chem. Soc. <\/i><\/em><strong>2020<\/strong>, <em><i>142<\/i><\/em>, 21254.\u00a0doi:<a href=\"https:\/\/doi.org\/10.1021\/jacs.0c09923\"><u>10.1021\/jacs.0c09923<\/u><\/a><u>.<\/u><\/li>\n<li>[4]\u00a0F.\u00a0Li,; C. Pei,; R. M. Koenigs, <em><i>Angew. Chem., Int. Ed. <\/i><\/em><strong>2022<\/strong>, <em><i>61<\/i><\/em>,\u00a0e202111892.\u00a0doi:<a href=\"https:\/\/doi.org\/10.1002\/anie.202111892\"><u>10.1002\/anie.202111892<\/u><\/a><u>.<\/u><\/li>\n<li>[5] F.\u00a0Julia, T. Constantin, D. Leonori, <em><i>Chem. Rev. <\/i><\/em><strong>2022<\/strong>, <em><i>122<\/i><\/em>, 2292.\u00a0doi:<a href=\"https:\/\/doi.org\/10.1021\/acs.chemrev.1c00558\"><u>10.1021\/acs.chemrev.1c00558<\/u><\/a><u>.<\/u><\/li>\n<li>[6] P.\u00a0Li, J. Zhao, L. Shi, J. Wang, X. Shi, F. Li, <em><i>Nat. Commun. <\/i><\/em><strong>2018<\/strong>, <em><i>9<\/i><\/em>,\u00a01972.\u00a0doi:<a href=\"https:\/\/doi.org\/10.1038\/s41467-018-04331-4\"><u>10.1038\/s41467-018-04331-4<\/u><\/a><u>.<\/u><\/li>\n<li>[7] M.\u00a0Sayes, G. Benoit, A. B. Charette, <em><i>Angew. Chem., Int. Ed. <\/i><\/em><strong>2018<\/strong>, <em><i>57<\/i><\/em>, 13514.\u00a0doi:<a href=\"https:\/\/doi.org\/10.1002\/anie.201807347\"><u>10.1002\/anie.201807347<\/u><\/a><u>.<\/u><\/li>\n<li>[8]\u00a0C. Huang, J. Li, J.\u00a0Ai, X. Liu, W. Rao, S. Wang, <em><i>Org. Lett. <\/i><\/em><strong>2020<\/strong>, <em><i>22<\/i><\/em>, 9128.\u00a0doi:<a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.0c03562\"><u>10.1021\/acs.orglett.0c03562<\/u><\/a><u>.<\/u><\/li>\n<\/ul>\n<p style=\"text-align: justify;\">\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb\uff1a \u8fd1\u65e5\uff0c\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u7684\u5434\u56fd\u9a84\u8bfe\u9898\u7ec4\u5728Org. Lett.\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u53ef\u89c1\u5149\u8bf1\u5bfc\u7684CF3CHN2\u3001\u7898\u4e0e\u70ef\u4e19\u57fa\u781c\u884d\u751f\u7269\u4e4b\u95f4\u7684\u81ea\u7531\u57fagem-Iodoallylation\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u03b1-CF3-\u53d6\u4ee3\u7684\u9ad8\u70ef\u4e19\u57fa\u7898\u5206\u5b50\u7684\u6784\u5efa\u3002 Visible-Light-Induced Radical gem-Iodoallylation of 2,2,2-Trifluorodiazoethane Liu, T. Pang, W. Yao, F. Zhong, G. Wu, Org. Lett.2023, 25,1958. doi: 10.1021\/acs.orglett.3c00464. \u6b63\u6587\uff1a \u4e09\u6c1f\u7532\u57fa\u7ed3\u6784\u5355\u5143\u5e7f\u6cdb\u5b58\u5728\u4e8e\u4e00\u7cfb\u5217\u519c\u7528\u5316\u5b66\u54c1\u3001\u836f\u54c1\u4ee5\u53ca\u5404\u7c7b\u529f\u80fd\u6750\u6599\u4e2d\u3002\u5e76\u4e14\uff0c\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u91c7\u7528CF3CHN2\u53c2\u4e0e\u7684\u6709\u673a\u5408\u6210\u8f6c\u5316\u7b56\u7565\u7684\u76f8\u5173\u7814\u7a76\uff0c\u4ee5\u53ca\u5907\u53d7\u8bf8\u591a\u7814\u7a76\u56e2\u961f\u7684\u5e7f\u6cdb\u5173\u6ce8\u00a0(Figure 1)\u00a0[1]-[4]\u3002\u8fd9\u91cc\uff0c\u53d7\u5230\u8fd1\u5e74\u6765\u901a\u8fc7C-I\u952e\u65ad\u88c2\u5f62\u6210\u7684\u81ea\u7531\u57fa\u53c2\u4e0e\u7684\u5149\u5316\u5b66\u53cd\u5e94\u65b9\u6cd5\u5b66[5]\u4ee5\u53ca\u5728\u5149\u6c27\u5316\u8fd8\u539f\u6216\u70ed\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u901a\u8fc7\u4e8c\u7898\u4e59\u9178\u4e59\u916f\u4e2d\u95f4\u4f53\u53c2\u4e0e\u7684\u73af\u52a0\u6210\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u5b58\u5728\u7684\u91cd\u6c2e\u7fa7\u9178\u916f\u6d3b\u5316\u8def\u5f84[6]\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u7684\u5434\u56fd\u9a84\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u53ef\u89c1\u5149\u8bf1\u5bfc\u7684CF3CHN2\u3001\u7898\u4e0e\u70ef\u4e19\u57fa\u781c\u884d\u751f\u7269\u4e4b\u95f4\u7684\u81ea\u7531\u57fagem-Iodoallylation\u53cd\u5e94\u65b9\u6cd5\u5b66 (Figure 1c)\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528CF3CHN2\u4f5c\u4e3a\u6c1f\u70f7\u57fa\u5316\u8bd5\u5242 (fluoroalkylating reagent)\u3001I2\u4f5c\u4e3a\u7898\u5316\u8bd5\u5242\uff0c1a\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528[Ir(dtbbpy)(ppy)2]PF6\u4f5c\u4e3a\u5149\u50ac\u5316\u5242\uff0cEt3N\u4f5c\u4e3a\u78b1\uff0c\u84dd\u5149LED\u8f90\u5c04\uff0cDCM\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a\u5ba4\u6e29\uff0c\u6700\u7ec8\u83b7\u5f9787%\u6536\u7387\u7684gem-Iodoallylation\u4ea7\u72692\u3002 \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217\u70ef\u4e19\u57fa\u781c\u5e95\u7269 (Scheme 1)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002 \u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u81ea\u7531\u57fagem-Iodoallylation\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u00a0(Scheme 2)\u3002 \u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u5bf9\u4e0a\u8ff0\u81ea\u7531\u57fagem-Iodoallylation\u8fc7\u7a0b\u7684\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u7814\u7a76\u00a0(Figure 2)\u3002 \u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\u4ee5\u53ca\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053[7]-[8]\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Figure 3)\u3002 \u603b\u7ed3\uff1a\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u7684\u5434\u56fd\u9a84\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u53ef\u89c1\u5149\u8bf1\u5bfc\u7684CF3CHN2\u3001\u7898\u4e0e\u70ef\u4e19\u57fa\u781c\u884d\u751f\u7269\u4e4b\u95f4\u7684\u81ea\u7531\u57fagem-Iodoallylation\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u03b1-CF3-\u53d6\u4ee3\u7684\u9ad8\u70ef\u4e19\u57fa\u7898\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u81ea\u7531\u57fagem-Iodoallylation\u7b56\u7565\u5177\u6709\u5e7f\u6cdb\u7684\u5e95\u7269\u5e94\u7528\u8303\u56f4\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u6e29\u548c\u7684\u53cd\u5e94\u6761\u4ef6\u7b49\u4f18\u52bf\u3002 \u53c2\u8003\u6587\u732e\uff1a [1] L.\u00a0Mertens, R. M. Koenigs, Org. Biomol. Chem. 2016, 14, 10547. doi:10.1039\/C6OB01618A. [2]\u00a0X.\u00a0Zhang, Z. Liu, X. Yang, Y. Dong, M. Virelli, G. Zanoni, E. A. Anderson, X.\u00a0Bi,\u00a0Nat. Commun. 2019, 10, 284.\u00a0doi:10.1038\/s41467-018-08253-z. [3]\u00a0S. J. T.\u00a0Jonker, R. Jayarajan, T. Kireilis, M. Deliaval, L. Eriksson, K. J. Szabo, J. Am. Chem. Soc. 2020, 142, 21254.\u00a0doi:10.1021\/jacs.0c09923. [4]\u00a0F.\u00a0Li,; C. Pei,; R. M. Koenigs, Angew. Chem., Int. Ed. 2022, 61,\u00a0e202111892.\u00a0doi:10.1002\/anie.202111892. [5] [&hellip;]","protected":false},"author":26,"featured_media":45286,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1271],"tags":[4097,3652,59],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/04\/1a750e3c13cd7479ead56e40131abf91.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-bMp","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/45285"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=45285"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/45285\/revisions"}],"predecessor-version":[{"id":45297,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/45285\/revisions\/45297"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/45286"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=45285"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=45285"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=45285"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}